Дисертації з теми "ADH-1"
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Meyer, Arnd. "Programmbeschreibung SPC-PM3-AdH-XX - Teil 1." Universitätsbibliothek Chemnitz, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-136749.
Повний текст джерелаTurcinelli, Silvia Regina. "Caracterização molecular de um mutante para o gene Adh - 1 identificado em um variante somacional de milho." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316405.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-07-21T19:39:01Z (GMT). No. of bitstreams: 1 Turcinelli_SilviaRegina_M.pdf: 5122448 bytes, checksum: f181f23e777e96ab7baab2729be3de58 (MD5) Previous issue date: 1996
Mestrado
Genetica
Mestre em Ciências Biológicas
Berelov, Ilya. "Occupation and abandonment of Middle Bronze Age Zahrat adh-Dhra' 1, Jordan the behavioural implications of quantitative ceramic analyses /." Oxford (England) : Archaeopress, 2006. http://catalogue.bnf.fr/ark:/12148/cb40157593k.
Повний текст джерелаQuaresma, Ana Cristina de Azevedo. "Isolamento e modificação de xilanas da pasta branca." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13274.
Повний текст джерелаA remoção de xilanas na pasta branca kraft pode ser uma prática convencional para a produção de materiais celulósicos para uso não papeleiros, tais como derivados de celulose, celulose microfibrilada, entre outros. As xilanas têm uma ampla gama de aplicações nas indústrias farmacêuticas, papeleiras e alimentares. Na indústria da pasta e papel, a xilana pode ser utilizada como revestimento dos papéis substituindo polissacarídeos utilizados normalmente, como o amido. Para a aplicação das xilanas nesta área, a sua massa molecular tem de ser muito superior à das xilanas existentes na pasta celulósica, pelo menos 50 𝑘𝐷𝑎. O objetivo deste trabalho consiste no estudo da possibilidade de extração e isolamento de xilanas de pasta branca kraft de eucalipto, elucidar a possibilidade de aumento do peso molecular das mesmas para posterior utilização na indústria papeleira. A xilana foi extraída com soluções aquosas de NaOH a 10% durante 1 hora, sendo posteriormente acidificada e isolada sob a forma de precipitado. Aditivamente, as xilanas foram purificadas por diálise contra água destilada. As xilanas obtidas foram caracterizadas por teor de cinzas, composição de açúcares, estrutura e peso molecular. O teor de cinzas foi avaliado recorrendo ao método termogravimetrico, a análise de açúcares por cromatografia gasosa com alditol-acetato, a estrutura da xilana foi elucidada recorrendo às técnicas de 1H RMN e 13C RMN em estado sólido e o peso molecular foi utilizada a técnica de cromatografia por permeação de gel. Os resultados obtidos demonstraram que as xilanas não purificadas apresentam teor de cinzas elevado (55−81%), o peso molecular médio ponderal das xilanas extraídas estavam compreendidos no intervalo dos 26,3 – 28,2 kDa. Pela análise dos monossacarídeos e 1H RMN podemos concluir que as xilanas isoladas são 2−𝑂−metil−𝛼−𝐷− glucurono − 𝐷− xilanas. A modificação das xilanas foi efetuada utilizando os métodos de bioconjugação em soluções aquosas num sistema acidificado de ADH na presença de EDC e através de derivados de metilol em dimetilsulfóxido. Os produtos derivatizados foram caracterizados por teor de cinzas, estrutura e peso molecular. O teor de cinzas foi avaliado recorrendo ao método termogravimetrico, a estrutura da xilana foi elucidada recorrendo às técnicas de FTIR, 1H RMN e 13C RMN em estado sólido e a massa molecular foi utilizada a técnica de cromatografia por permeação de gel. O peso molecular médio ponderal através do método de bioconjugação chegou quase aos valores desejados para este tipo de compostos.
The removal of xylan in kraft bleached pulp can be a conventional practice for the production of non-cellulosic materials papermakers use, such as cellulose derivatives, microfibrillated cellulose, among others. The xylan have a wide range of applications in the pharmaceutical, paper and food industries. In the pulp and paper industry, the xylan can be used to coat papers replacing normally used polysaccharides such as starch. For the application of xylan in this area, its molecular weight must be much higher than the existing xylan in pulp, at least 50 kDa. The objective of this work is to study the possibility of extraction and isolation of xylan from kraft bleached eucalyptus pulp, to elucidate the possibility of increasing the molecular weight of these for later use in the paper industry. Xylan was extracted with aqueous solution of NaOH 10% for 1 hour and subsequently acidified and isolated in the form of precipitate. Additively, the xylan were purified by dialysis against distilled water. The xylan obtained were characterized by ash content, sugar composition, structure and molecular weight. The ash content was evaluated using the thermogravimetric method, the analysis of sugars by gas chromatography with alditol acetate, the structure of xylan was elucidated using techniques 1H NMR and solid state 13C NMR and for molecular mass was used chromatography technique. The results showed that the non-purified xylan show a high ash content (55-81%), the weight average molecular weight of the extracted xylan were in the range of 26.3 to 28.2 kDa. Form the analysis of monosaccharides and 1H NMR we can conclude that isolated xylans are 2-O-methyl-α-D-glucurono - D-xylan. The modification of xylan was carried out using the methods of bioconjugation in aqueous solutions in a acidified system with ADH in the presence of EDC and via methylol derivatives in dimethylsulphoxide solutions. The derivatized products were characterized by ash content, structure and molecular weight. The ash content was evaluated using the thermogravimetric method, the xylan structure was elucidated using FTIR techniques, 1H NMR and 13C NMR in solid form and the technique of molecular weight by gel permeation chromatography was employed. The average molecular weight of the compounds obtained by the method of bioconjugation reached almost the desired values.
Calvert, Charlene. "Arabidopsis poly (ADP-ribose) polymerase-1 (AtPARP-1) and resistance to genotoxic stress." Thesis, University of East Anglia, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426681.
Повний текст джерелаScarinci, Carlos. "The phase space of 2+1 AdS gravity." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12814/.
Повний текст джерелаKandan-Kulangara, Febitha. "Poly(ADP-ribose) polymerase-1 (PARP-1) and RNA interference (RNAI) during cell death." Doctoral thesis, Université Laval, 2013. http://hdl.handle.net/20.500.11794/25972.
Повний текст джерелаMiszura, Alexandre Arantes. "Efeito do crescimento compensatório sobre a puberdade de novilhas Nelore." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10135/tde-18042017-142425/.
Повний текст джерелаThe aim of this study was to evaluate the effect of growth rates and compensatory growth on the age and weight at puberty of heifers. For that, 120 Nellore heifers, weaned at eight months of age, daughters of 6 bulls, with initial body weight of 180±8.6 kg were used. The experimental design was randomized blocks (sires). The experimental period was from 8 to 18 months of age. Treatments were: 1) High ADG (ad libitum DMI) throughout the experimental period (HIGH), 2) Mid ADG (0.6kg/d) throughout the experimental period (MID), 3) Feed restriction for 4 months (0.2kg/d), followed by ad libitum DMI with compensatory growth (RESTRICT), 4) ad libitum DMI (High ADG) for 2 months, alternating with feed restriction (0.2kg/d), throughout a period of 10 months (ALTERNATE). The diet was composed of ground corn (70%), sugarcane bagasse (12%), soybean meal (16%), mineral mixture (1%) and urea (1%). Weekly gynecological examination was performed, whereas the manifestation of puberty was monitored by means of ultrasonography. Additional blood samples were collected for determination of IGF-1 and leptin. At the end of the experimental period, the heifers that did not reach puberty were submitted to a puberty induction protocol with progesterone. The continuous variables were analyzed by the MIXED procedure and the binomial variables evaluated by the procedures GLIMMIX (SAS 9.3). There was no difference in the percentage of pubertal heifers at 18 months of age, weight and age at puberty between treatments. However, the ADG throughout the experiment (P<0.01) and until puberty (P<0.01) was greater in heifers submitted to HIGH, compared to the other treatments. Moreover, heifers submitted to HIGH had greater DMI (P<0.01) than the RESTRICT, with the magnitude of this difference of 20%. The feed efficiency (P<0.01) were 0.128, 0.120, 0.146 and 0.113 for HIGH, MID, RESTRICT and ALTERNATE respectively. There was treatment x age interaction (P=0.02) for IGF-1, in which the ALTERNATE had greater concentration of IGF-1 at 12 and 16 months of age when compared to the other treatments. The leptin concentration was greater (P=0.03) in HIGH when compared to the MID. In relation to the percentage of heifers that responded to the induction, there was no difference between treatments and about 80% of the heifers responded to induction. Heifers submitted to feed restriction had a reduced DMI, hence, the compensatory growth was an efficient nutritional strategy to feed efficiency and did not differ age at puberty.
Pottier, Aurore Hénichart Jean-Pierre. "Conception, synthèse et évaluation pharmacologique de pyrrolo[3,4-b]quinoléines condensées, ligands potentiels de l'ADN." [S.l.] : [s.n.], 2003. http://www.univ-lille1.fr/bustl-grisemine/pdf/extheses/50376-2003-83-84.pdf.
Повний текст джерелаLyonnais, Sébastien. "VIH-1, protéine de nucléocapside, ADN, Flap central et quartets de guanine : assemblages et modelages in vitro." Paris 6, 2002. http://www.theses.fr/2002PA066234.
Повний текст джерелаNourry, Arnaud Huet François. "Synthèse d'analogues de la lavendamycine diversement substitués et d'analogues à géométrie contrainte." [S.l.] : [s.n.], 2006. http://cyberdoc.univ-lemans.fr/theses/2006/2006LEMA1016.pdf.
Повний текст джерелаRivière, Lise. "Étude des facteurs viraux impliqués dans l'import nucléaire du génome du HIV-1 et dans l'infection des cellules en arrêt de croissance." Lyon, École normale supérieure (sciences), 2009. http://www.theses.fr/2009ENSL0514.
Повний текст джерелаLentiviruses such as HIV-1 have the unique ability among Retroviridae to infect efficiently non-dividing cells. This property is important in vivo because it allows the infection of differentiated cells, like macrophages and dendritic cells, that are among the first targets of HIV-1 in the organism. This implies the import of the viral genome through an intact nuclear envelope, independently of its dissociation occuring during mitosis. This nuclear import seems to be active and dependant on nucleophilic elements present within Lentiviruses nucleoproteic complexes. For HIV-1, 4 potentially nucleophilic factors have been identified : the viral proteins matrix (MA), integrase (IN) and Vpr, as well as a three stranded structure in HIV-1 neosynthsized DNA, the DNA flap, whose formation depends on the cPPT and CTS sequences. However, although several studies have been carried out in the past, the role of these elements in the nuclear import of the viral genome is still controversial. We decided to realize a global study in order to reassess the relative contribution of these different elements in this step in the context of the different primary cell targets of HIV-1 infection. Among the elements we examined here the DNA flap was the sole element to play a role in nuclear import, whereas MA, IN and Vpr proteins were dispensable. However, the DNA flap only played a partial role, which was not apparent in all cell types and was independent from theirs cycling status. This suggests on one hand that passage through the nuclear pore may be common step during lentiviral infection and on the other, it suggests the existence of additional nucleophilic elements within HIV-1 nucleoproteic complexes. Moreover, in agreement with recent studies, our results suggest that the capside seems to be involved in the infection of non-dividing cells, but influences a step different from nuclear import
Kretov, Dmitry. "Mechanisms of YB-1/nucleic acids interaction and its implication in diverse cellular processes." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLE017.
Повний текст джерелаYB-1 is a member of the cold-shock protein superfamily. It binds to both RNA and DNA. Correlations between high level of YB-1, elevated expression of P-glycoprotein MDR1 and poor patient prognosis were made for several types of cancer. The role of YB-1 in cancerogenesis can be accounted by several mechanisms: i) activation of transcription; ii) participation in DNA repair; iii) regulation of translation. The first two proposals imply a nuclear localization for YB-1, despite the fact that it appears mainly in the cytoplasm under physiological conditions and the mechanisms for its nuclear accumulation remain unclear. In this work we attempted to identify the mechanisms that trigger the nuclear translocation of YB-1. It appeared that this depends on the level of mRNA in the cytoplasm and thus on active transcription, rather than on the presence of nuclear DNA damages. In contrast to its function in the nucleus, the role of YB-1 in the regulation of translation was clearly established. YB-1 may therefore orchestrate a translation bias in order to promote cancer progression independently of its putative functions in the nucleus. Here we demonstrated, using atomic force microscopy and biochemical methods, that YB-1 binds mRNA in a highly cooperative manner and this has direct consequences on mRNA selection and following translational modulation. Beyond this research, we took advantage of our knowledge of the biology of YB-1 to develop a new method to detect protein-protein interactions in cellular context, using YB-1 as model protein. Besides the fact that we confirmed ability of YB-1 to make oligomers in the presence of mRNA, we also highlighted its potential interaction with Lin28, using this method
Harper, Ruth Ann. "Attributions for the behaviours of young adults with ADHD 1." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514370.
Повний текст джерелаUllrich, Oliver. "Mechanismen protektiver und destruktiver Funktionen der Poly(ADP-Ribose)-Polymerase-1 (PARP-1) bei Zell- und Gewebeschädigungen." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965628086.
Повний текст джерелаRichard, Véronique. "Ciblage thérapeutique de la poly(ADP-Ribose)Polymérase-1 (PARP-1) dans le traitement du cancer carcinoïde." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28112/28112.pdf.
Повний текст джерелаWatson, Martha. "The role of poly (ADP-ribose) polymerase 1 (PARP-1) as a transcriptional regulator in prostate cancer." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443017.
Повний текст джерелаUllrich, Oliver. "Mechanismen protektiver und destruktiver Funktionen der Poly(ADP-Ribose)-Polymerase-1 (PARP-1) bei Zell- und Gewebeschädigungen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13826.
Повний текст джерелаDuring the last decade of neurobiological research, it became clear that inflammatory pathways in the CNS, involving a network of non-neuronal and neuronal cells, are contributing mainly to the onset and progress of several major neurodegenerative diseases. Therapeutic approaches must therefore focus on the protection of initially surviving neurons from this secondary inflammatory damage. One major component of secondary neuronal damage is the migration of macrophages and microglia cells towards the sites of injury where they produce large amounts of toxic cytokines and oxygen radicals. In a macrophage-like cell line and in phagocytosing microglial cells a nuclear proteolytic system was identified, which was able to recognize and degrade oxidatively-damaged nuclear proteins, in particular histones. In contrast to the previous concept of relatively long-living histone proteins, they are rapidly degraded and removed from the chromatin within minutes after oxidative damage. This rapid degradation was dependent on the non-covalent interaction of the 20S proteasome with the automodified poly(ADP-ribose)-polymerase-1 (PARP-1). Therefore, the PARP-1 has been identified as a signal molecule between the detection of a chromatin-damage and a protective cellular response, which enables microglial cells to survive their own activation state. The regulation of this PARP-proteasome-system depends on the differentiation state of macrophage-like cells and is also functionally involved in the chemotherapy-resistance of human leukemia cells. Moreover, PARP-1 regulates the expression of the integrin CD11a by interaction with the translocated NF-kappaB and HMG-I(Y) and therefore microglia migration towards the sites of neuronal injury. These findings renders the PARP as potential target for therapeutic interventions to inhibit destructive microglial migration and therefore to protect initially surviving neurons from inflammatory damage.
Lombard-Platet, Gaël. "Caractérisation et purification du facteur cellulaire HEB1 intervenant dans l'activation de la transcription du virus HTLV-I par Tax1." Lyon 1, 1993. http://www.theses.fr/1993LYO1T088.
Повний текст джерелаRacine, Pierre-Jean. "Etude du contrôle spatiotemporel de la rétrotranscription au cours des phases tardives de la réplication du VIH-1." Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON1T023/document.
Повний текст джерелаHIV-1 is a retrovirus whose genome consists of RNA (gRNA). Conversion of this gRNA into DNA is made during reverse transcription (RTion). It can convert single-stranded gRNA in a double-stranded DNA molecule, which is then integrated into the genome of the host cell to ensure the virus replication. The RTion is carried out in the early hours of infection, soon after virus entry. The nucleocapsid protein (NC) is actively involved in this conversion. The NC protein chaperones this process via its nucleic acid annealing activities and its interactions with the reverse transcriptase enzyme. To function the NC needs its two conserved zinc fingers and flanking basic residues. The team recently discovered a new role for the NC. When the NC has a mutation of its zinc fingers or its N-terminal basic region, the RTion is made prematurely before the release of new viruses, i.e. during the later stages of HIV replication. We call it «late RTion". This RTion generates virus with a high level of viral DNA. These results indicate that the NC plays a role in the spatio-temporal control of the RTion during HIV replication. My thesis project was to identify potential partners of the NC in the late RT process and to elucidate the molecular mechanisms involved.The experimental approach mainly used in my project is the production of HIV-1 particles (pNL4-3) and the analysis of their nucleic acid content by Q-PCR in real-time. By measuring the effect of the presence and absence of the viral protein Vif on the initiation of late RTion in cells producing HIV-1, we demonstrated the role of Vif in late RTion regulation. We also showed that the gRNA, and particularly its 5'UTR, is a key partner of the NC and Vif in the control of the late RTion. Our comparative study between HIV-1 and an old and simple (no Vif) retrovirus such as the Murine Leukemia Virus (MuLV) showed that the ability of the HIV-1 NC to control late RTion is not common to all retroviruses.To better understand the role of NC during the late stages of the HIV-1 replication, we used the TIRF microscopy (Total Internal Reflection Fluorescence Microscopy) in live cells. The TIRF allows the visualization of the viral assembly, budding and release of virus particles at the plasma membrane of the host cell. Although the NC does not contribute to the kinetic of the virus assembly, it is however strongly involved in the control of the budding and the release of the HIV-1 particles. Experiences of trans-complementation of a HIV-1 mutant (deletion of ZF2) showed that NC contributes to the recruitment of the cellular ESCRT machinery (Endosomal Sorting Complex Required for Transport) at the assembly sites, particularly through the Tsg101 pathway
Merad, Hayate. "Identification de zones sensibles dans l'integrase du VIH-1 et recherche de nouveaux inhibiteurs." Paris 13, 2006. http://www.theses.fr/2006PA132002.
Повний текст джерелаElser, Michael. "Transcriptional regulation of stress responses by poly(ADP-ribose) polymerase 1 /." Zürich, 2007. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253051.
Повний текст джерелаCunha, Stéphanie. "Effets sur la spermatogenèse de la déficience en poly (ADP) polymerase-1 (PARP-1) chez la souris adulte." Lyon 1, 2008. http://www.theses.fr/2008LYO10014.
Повний текст джерелаSince fifty years, the number of male reproductive system changes increases. These pathologies are grouped into an entity, the testicular dysgenesis syndrome, involvind changes of apoptosis and cell proliferation. Tha animal'smodel with these pathologies allow for bette understanding the mechanisms involved. In adult mice, PARP-1 deletion, a DNA repair protein, will result in germ cells apopotosis decreased with changes of protein expression involved in apopotosis pathways, cellular proliferation and co-regulation of androgen receptor. In conclusion, PARP-1 deletion leads to impaired the apopotosis / proliferation balance in the mice adult testis, showing that PARP-1 plays a principal role in the germinal cells differentiation
El, Khoury Léa. "Etude de complexes d'inhibiteurs à visée thérapeutique : applications à des métalloprotéines impliquées dans des pathologies." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066016.
Повний текст джерелаThe catalytic functions of integrase (IN) of Human Immunodeficiency Virus (HIV-1) are strictly necessary for the integration of the viral genome into the host cells. To this day, three anti-IN inhibitors belonging to the diketoacids are used in therapy: raltegravir, elvitegravir and dolutegravir. However, under treatments with these drugs, patients develop resistance mutations. In this work, we seek to better understand the interaction of the three drugs with viral DNA. This work also contributed to the design of novel molecules. These should be endowed with increased DNA binding affinities as a step towards overcoming viral resistance. The understanding of the inhibition mechanism of IN was pursued by the study of two monoclonal antibodies, 4F4 and 4C6, which are directed against sequence 147-175 of the catalytic core of HIV-1 IN, a peptide denoted K159. The results show that the antibodies recognize their epitopes in IN. We also aim to target an HIV-1 nucleocaspid protein NCp7 involved in many stages of the viral cycle. We have thus studied the structure of NCp7 and its viral DNA complex. We were able to determine the interactions responsible for the structuring and thus the functions of these complexes. Then, we evaluated the interactions of NCp7 with an inhibitor of the thioester family, C247, which acts as a zinc ejector. Finally, from the methodological standpoint, we have refined in SIBFA (Sum of Interaction Between Fragments Ab initio computed) the representation of the sp2 and sp lone pairs in conjugated molecules
Breitman, Maryana I. "Biochemical characterization of COPI and its interactions with ARF1 G-protein /." Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1481657561&sid=15&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Повний текст джерелаRobu, Mihaela. "Rôle de la poly (ADP-ribose) polymérase-1 (PARP-1)dans la réparation de l'ADN par excision de nucléotides." Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27406/27406.pdf.
Повний текст джерелаKunze, Catarina Alisa [Verfasser]. "Aldehyddehydrogenase 1 A1, Thymosin-β15A und Poly(ADP-Ribose)-Polymerase-1 als prognostische Marker im Ovarialkarzinom / Catarina Alisa Kunze". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1067098992/34.
Повний текст джерелаWoodhouse, Bethany Clare. "The role of poly(ADP-ribose) polymerase-1 in base excision repair." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670110.
Повний текст джерелаCoeytaux, Emmanuel. "Utilisation d' un peptide du VIH-1 pour la vectorisation d' ADN." Paris 7, 2003. http://www.theses.fr/2003PA077146.
Повний текст джерелаRochelle, Tristan. "Signalisation des GTPases de la famille Rho dans les phénotypes migratoires induits par les différentes formes de Bcr-Abl." Thesis, Poitiers, 2012. http://www.theses.fr/2012POIT1401/document.
Повний текст джерелаBcr-Abl chimeric oncogenes (p190bcr-abl and p210bcr-abl) result from the t(9,22) chromosomal translocation that fuse the bcr and the c-abl genes. p210bcr-abl and p190bcr-abl are associated with Chronic Myelogenous Leukemia (CML) and a subset of Acute Lymphoblastic Leukemia (ALL) respectively. The only difference between these two chimeras is the presence of a specific RhoA-GEF domain in the p210bcr-abl oncogene. Bcr-Abl expression in Ba/F3 lymphoblasts induces spontaneous migration of these cells without apparent directionality. Motility triggering of Bcr-Abl-expressing Ba/F3 depends on the RhoGTPase Rac1.RhoA activity is associated with a typical amoeboid movement of Ba/F3p210 cells embedded in Matrigel™ 3D matrix, whereas the Ba/F3p190 cells, devoid of RhoA activity, display a rolling-type motility. In this work we showed that activation of the RhoA effector ROCK1 triggers two parallel pathways which are both necessary for amoeboid movement: 1) the Myosin Light chain (MLC) pathway 2) ADF family proteins (Actin Depolymerizing Factor) pathway, specifically the ADF/destrin isoform. Besides, we showed that Ba/F3p190 cells could assemble invadopodia-like structures. The formation of these structures is driven by the reduction of RhoA activity associated with the absence of the DH/PH domain in p190bcr-abl and correlates with an increase in Cdc42 activity. We finally demonstrated that the RhoA/ROCK pathway is constitutively activated in CD34+ cells isolated from CML patients while not in their normal counterparts. We also demonstrated that this activation is independent of the tyrosine Kinase activity of Bcr-Abl
Cloutier, Jean-François. "Caractérisation et distribution des dommages à l'ADN induits par les Métabolites réactifs de la 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone spécifique à la fumée de tabac." Doctoral thesis, Université Laval, 2001. http://hdl.handle.net/20.500.11794/17778.
Повний текст джерелаDOUCET, CHABEAUD GAELLE. "Caracterisation fonctionnelle d'un gene radio-induit chez arabidopsis thaliana : le gene codant la poly(adp-ribose)polymerase-1 (athparp-1)." Université Louis Pasteur (Strasbourg) (1971-2008), 2000. http://www.theses.fr/2000STR13098.
Повний текст джерелаKorei, Maesumeh. "Caractérisation des complexes cycline-Cdc28 impliqués dans la résection des télomères déprotégés chez Saccharomyces cerevisiae." Mémoire, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/7733.
Повний текст джерелаBataille, Dominique. "Analyses de la structure des intermédiaires de la réplication de l'ADN du virus Herpes simplex de type 1." Lyon 1, 1997. http://www.theses.fr/1997LYO10146.
Повний текст джерелаLogvinoff, Carine. "Manipulations de génomes herpétiques in situ par le système Cre-loxP : aspects fondamentaux et appliqués." Lyon 1, 2000. http://www.theses.fr/2000LYO10144.
Повний текст джерелаWijeratne, Dissanayakage Geethika Sonali. "Fundamental Limits of Non-Coherent Rician Fading Channels with 1-Bit Output Quantization." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1499864736575987.
Повний текст джерелаSoundasse, Munir. "Caractérisation et rôle de l'ADN non intégré du VIH-1 dans le cycle de réplication virale." Paris 7, 2013. http://www.theses.fr/2013PA077252.
Повний текст джерелаThe HIV-1 DNA is present in different forms, integrated into the cellular genome, or unintegrated: linear (DNAL) or circular (I-LTR or 2-LTR circle). The aim of this work is to characterize and identify the role of the different unintegrated molecules in HIV-1 replication cycle and more particularly 2-LTR circles. By establishing new technologies to quantify DNAL (unprocessed and processed forms) and 1-LTR circles, we described, in an exhaustive manner, the dynamics of all viral DNA forms during viral infection in different conditions. Firstly, we have demonstrated the strong efficiency of DNAL 3'-processing reaction, which takes place very early in the viral cycle, and the modulation of this reaction by various compounds that inhibit integration. In addition, we have shown that the 1-LTR circles formation implies, non-exclusively, the homologous recombination pathway and the viral reverse transcription. Secondly, we highlighted the reversibility of anti-integrase molecules such as Raltegravir (RAL), The RAL reversibility ailowed us to show, in vitro and ex vivo, that 2-LTR circies, described yet as moiecuies having no significant role in the replication cycle, are an efficient substrate involved in the integration reaction mediated by the integrase. Therefore, our results demonstrate that 2-LTR circles are not a "dead-end" molecule but cari be considered like a backup molecule for the viral information
Saydam, Reyhan. "Executive Functions In Children With Attention Deficit / Hyperactivity Disorder." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608885/index.pdf.
Повний текст джерелаand thirty seven children (4 girls and 33 boys) were classified as ADHD-Comorbide group (ADHD-C with Oppositional Defiant Disorder consists of 4 girls and 31 boys, and/or Conduct Disorders consists of 2 boys). Thirty six children (6 girls and 30 boys
age range: 7- 12) were assigned as control group by matching with the ADHD groups according to the WISC-R Full Scale IQ score, sex and age. Conner&rsquo
s Parental and Teacher Rating Scales, Child Behavior Check List and Wechsler Intelligence Scale Revised, Tower of London Test, Wisconsin Card Sorting Test, Stroop Color Word Test, Cancellation Task, Trail Making Test, California Verbal List Test for Children, Verbal Fluency Test, Continuous Performance Test, Go-No-Go Task and Bender-Gestalt Test were used for the assessment of children. The data were analyzed by one-way within subject ANOVA for all dependent variables measured by the assessment tools. Additionally discriminant function analyses were conducted to determine the variables that differentiate the three ADHD groups and control group. Outcome of study indicated that subjects in ADHD-Comorbid group had more severe Executive Function (EF) deficits than subjects in ADHD-I and ADHD-C group. The findings were discussed in the light of the literature.
Zaniolo, Karine. "La régulation de l'expression du gène de la poly(ADP-ribose) polymérase-1 (PARP-1) durant la cicatrisation de l'épithélium cornéen." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24516/24516.pdf.
Повний текст джерелаGhabreau, Lina. "Poly(ADP-ribose)polymérase-1 (PARP-1) et méthylation de l'ADN, nouveaux partenaires des récepteurs hormonaux dans la carcinogenèse de l'endomètre." Lyon 1, 2005. http://www.theses.fr/2005LYO10067.
Повний текст джерелаMitchell, Jody. "DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribose) polymerase-1 (PARP-1) function in response to DNA double strand breaks." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519482.
Повний текст джерелаHuot, Nicolas. "Relation entre l’expression des LAT et du gène RL2 pendant la latence du virus HSV-1." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114860/document.
Повний текст джерелаThe herpes simplex virus type 1 (HSV-1) establishes a latent infection in the nervous system of humans, in which latency associated transcripts (LATs) accumulate in infected neurons. The key role of LATs in the control of viral latency is well established. However, since their discovery in the 80s, their mechanism of action remains unclear.The LAT gene is transcribed into a 8.3 kb primary LAT that is rapidly spliced, leading to the formation of two stable LATs; LAT2kb and LAT1.5kb. Remarkably, the LAT2kb and LAT1.5kb are introns. Their stability is the result of a non-canonical sequence of the branching point, which results in maintaining the lariat structure.Moreover, the region of the genome encoding the LATs also contains the RL2 gene, encoding ICP0 that acts upstream in the cascade of viral reactivation. Previous studies have shown that RL2 unspliced transcripts may accumulate in the main site of HSV-1 latency (trigeminal ganglia). We have characterized these unspliced transcripts RL2 gene in latently infected tissues. They reproducibly contain intron 1 and are particularly abundant in latently infected tissues where LATs also accumulate. We distinguished several types of latently infected tissues, the two most representative examples being the trigeminal ganglion (strong expression of LATs and accumulation of non-spliced transcripts RL2) and, in the opposite, the superior cervical ganglion (no accumulation of LAT compared with the amounts expressed during the acute phase of infection, and little expression in non-spliced RL2 transcripts). In all cases, the reality of the latent nature of the infection was confirmed by the presence of viral genome with no expression of mature transcripts from early viral gene (represented by the thymidine kinase gene) or late (UL18 gene).These results suggest a relationship between the presence of LAT and the accumulation of non-spliced RL2 transcripts, which could be related to the maintenance of latent infection in these tissues
Purohit, Nupur. "Roles of poly(ADP-ribose) polymerase-1 in the ultraviolet radiation-induced skin carcinogenesis." Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/70364.
Повний текст джерелаThe exposure to solar ultraviolet radiation (UV) is essential to life and beneficial to human health. However, an overexposure to terrestrial solar UV, especially its most energetic component UVB, can cause skin cancers including the non-melanoma skin cancers (NMSC) in humans. The NMSC initiating properties of UVB arise predominantly from their ability to cause direct DNA damage such as cyclobutane pyrimidine dimers (CPD) and 6-4photoproducts (6-4PP), which are repaired via nucleotide excision repair (NER) pathway. The increased incidence of NMSC in patients with hereditary defects in NER pathway proteins underscores the importance of efficient NER in humans. Therefore, detailed understanding of the molecular operation of NER pathway can provide novel therapeutic targets for the prevention or treatment of skin cancers. One of the earliest responses of the mammalian skin cells to UVB-induced CPD or 6-4PP is the activation of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP1), which catalyzes the formation of polymers of ADP-ribose (PAR). The previous work from other teams and our laboratory have shown that PARP1 and its enzymatic activity facilitate NER in collaboration with UV-damaged DNA binding protein 2 (DDB2), which also rapidly accumulates at the CPD/6-4PP site during the DNA damage recognition stage of NER. However, many aspects of interaction of PARP1 with DDB2 and direct DNA damage are not understood. Therefore, the first aim of my doctoral project was to characterize the precise nature of binding of PARP1 vis-à-vis DDB2 at UV-induced CPD/6-4PP. My doctoral research demonstrates that PARP1 casts asymmetric footprint from −12 to +9 nucleotides on either side of the CPD/6-4PP in presence or absence of DDB2. We also demonstrated that PARP1 facilitates the binding of DDB2 to CPD/6-4PP. Moreover, our study reports DDB2-independent role of PARP1 during the DNA damage recognition phase in NER. Targeting the role of PARP1 in DNA strand break repair pathways has emerged as one of the successful strategies for the treatment of ovarian and breast cancers in last decade. Consequently, the ultimate translational goal of my doctoral project was to understand the implication of NER facilitating role of PARP1 in NMSC. In this regard, we first developed a PARP1-KO model in the albino hairless SKH-1 mouse strain, which is a widely adopted mouse model to study UVB-induced NMSC. Since SKH-1 mice mainly develop cutaneous squamous cell carcinoma (SCC) upon chronic UVB-exposure, our present study reports the role of PARP1 in development of SCC. Using the newly developed PARP1-KO and PARP1-WT SKH-1 mice with or without topical application of PARP inhibitor, we report that the absence of PARP1 or its activity in skin of both male and female SKH-1 mice significantly reduces the SCC tumor burden and prolongs the tumor latency period. The analyses of appearance and growth of individual tumors on a weekly basis during this protocol also revealed that targeting of PARP1 was most effective in suppressing the premalignant stage of the SCC development. Our results are surprising in light of the reported onco-suppressive property of PARP1 and its catalytic activity in alkylating DNA damage-induced tumorigenesis and the increased susceptibility of other NER protein knock-out mice to UVB-induced SCC. We reason that the roles of PARP1 in UVB-induced cellular processes other than NER, such as cell death and immune modulations, can account for our observation. While further studies are required to understand these roles of PARP1 in UVB-induced cellular processes, our study underscores the potential for use of PARP inhibitors as a novel chemopreventive agents against UVB-induced SCC.
Harand, Kristina Marie. "Assessment of Acrolein-induced Toxicity Using In-vitro Modeling to Evaluate the Role of PARP Inhibitors in Reducing Cytotoxicity." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6091.
Повний текст джерелаDamiani, Roberto Marques. "Influência da inibição de POLI (ADP-Ribose) polimerase (PARP-1) na toxicidade induzida pelos quimioterápicos doxorrubicina e mitoxantrona em células cardíacas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/150749.
Повний текст джерелаAs the number of people with cancer are globally increasing, the search for therapeutic approaches that increases efficiency decreasing harmful effects to patients is also growing, giving rise to cardio-oncology. Anthracyclines, e.g., doxorubicin (DOX), and anthracenediones, e.g., mitoxantrone (MTX), are drugs used in the chemotherapy of several cancer types, including solid and non-solid malignancies such as breast cancer, leukemia, lymphomas, and sarcomas. Although they are effective in tumor therapy, treatment with these two drugs may lead to side effects such as arrhythmia and heart failure. These drugs interact with iron to generate reactive oxygen species (ROS), target topoisomerase 2 (Top2), and impair mitochondria. PARP-1 inhibitors have emerged as a new alternative for treating certain types of malignancies in which the synthetic lethality can be exploited. Furthermore, it has been reported that DOX-induced cardiac cardiotoxicity is influenced by PARP-1 activity. The main goal of this thesis was, therefore, to evaluate PARP-1 inhibition influence in cardiac toxicity of DOX and MTX in cardiac cells. Cells were incubated for 24h with MTX or DOX in presence or absence of PARP-1 inhibitor. Viability, oxidative stress and genotoxicity assays have been conducted. Furthermore, phosphorylation of proteins involved in response to DNA damage (ATM, H2AX and MRE-11) were evaluated by western blot and immunofluorescence. Results demonstrated that inhibition of PARP-1, although decreasing ROS generation, decreases H9c2 cells viability after DOX or MTX by increasing DNA double strand break generation induced by these drugs.
Imbert, Bismuth Françoise. "Contribution à l'étude de l'hétérogénéité de l'activité uridyl diphosphoglucuronosyltransférase rénale et pulmonaire." Tours, 1985. http://www.theses.fr/1985TOUR3803.
Повний текст джерелаTumiotto, Camille. "Définition in silico d'épitopes induisant une réponse T cytotoxique en fonction de la variabilité virale du VIH-1 et de l'immunogénétique des patients." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0153/document.
Повний текст джерелаHIV (Human Immunodeficiency Virus) cure is the major challenge of the future but latent reservoir and inefficient immune response do not allow virus elimination. The immune response against HIV infection depends on host cells ability to correctly present viral epitopes to induce specific cytotoxic CD8+ T lymphocytes (CTL) response. This presentation of viral epitopes which could be improved by vaccination depends on the HLA (Human Leukocyte Antigen) system of the patient which is extremely variable. Accurately pre-stimulated, CTL would target and destroy efficiently virus-producing cells. Previous vaccine trials stimulating CTL response haven’t shown efficient virological response, presumably because epitopes used are generic without taking into account HIV-1 or patient’ immunogenetic variability.The aim of this work is to identify epitopes archived in the proviral DNA, considered to induce CTL response according to the HIV-1 and immunogenetic variability of the patients at therapeutic success. The goal is to use these peptides for a therapeutic vaccine and educate the immune system to control the viral replication without any antiretroviral treatment.One hundred and forty patients infected with HIV-1, followed at the University Hospital of Bordeaux, at therapeutic success for more than 6 months have been included in the Provir/Latitude 45 project between 2012 and 2017. A mapping of the distribution of viral subtypes of HIV-1 in Aquitaine was first performed. Analysis of more than 3200 HIV-1 genotypes conducted from 2012 to 2016 determined that the major viral subtype infecting patients living with HIV in the region is subtype B, followed by CRF02_AG which is predominant among the non-B viral subtypes. Focusing on the patients included in this project led us to find similar distributions. Following this initial analysis, a new recombinant virus composed of CRF06_cpx and subtype B could be identified. It is now referenced as CRF98_cpx. One of the patients included in the project is infected with this virus. In order to identify candidate epitopes that can serve as a therapeutic vaccine for the entire population or for a population group based on their immunogenetic characteristics, we combined the viral sequence data with the HLA typing of patients to predict the affinity in silico between an HLA and a peptide via IEDB algorithms. To automate data analysis, a software package, TutuGenetics, has been developed. This software exploits IEDB algorithms and makes it possible to study the variability of the presentation of epitopes by the different HLAs of the patient thanks to an MHC IC50 score determined for each HLA-viral sequence pair. This software has been validated by comparing the analysis of data from Next Generation Sequencing (NGS) with Sanger sequencing. Finally, for 140 patients included in the Provir project, TutuGenetics sliced the viral sequences in steps of 8 to 10 amino acids and MHC IC50 values were defined for all HLA-epitope combinations. A finer analysis allowed us to determine a list of 15 epitopes with high in silico affinity for major HLAs. These epitopes were selected by applying different filters and only HLA-peptide couples with more than 10 patients sequenced per position and by HLA were kept in this "Optimal_Provir" list.These in silico data will in a next phase be confirmed in vitro via functional immunology tests, then in vivo in macaques
Lee, Stella Yu-Chien. "Localization and targeting of B2-1, a guanine-nucleotide exchange factor for ADP-ribosylation factors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/NQ57353.pdf.
Повний текст джерелаEdmonds, Yvette M. "Toward a Quantitative Analysis of PARP-1 and Poly(ADP-ribosyl)ation in Cellular Senescence." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/39180.
Повний текст джерелаPh. D.
Al-Dosari, Ali Salem Al-Naseef. "Military organization in early Islam (AH 1 - 40 / AD 622- 661)." Thesis, University of Manchester, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496371.
Повний текст джерела