Добірка наукової літератури з теми "Adeno-Associated Viral (AAV) vectors"
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Статті в журналах з теми "Adeno-Associated Viral (AAV) vectors"
Bartlett, Jeffrey S., Rose Wilcher, and R. Jude Samulski. "Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors." Journal of Virology 74, no. 6 (March 15, 2000): 2777–85. http://dx.doi.org/10.1128/jvi.74.6.2777-2785.2000.
Повний текст джерелаLieber, André, Dirk S. Steinwaerder, Cheryl A. Carlson, and Mark A. Kay. "Integrating Adenovirus–Adeno-Associated Virus Hybrid Vectors Devoid of All Viral Genes." Journal of Virology 73, no. 11 (November 1, 1999): 9314–24. http://dx.doi.org/10.1128/jvi.73.11.9314-9324.1999.
Повний текст джерелаXuan, Keh Min, Nur Ain Mohd Asri, Rafeah Suppian, Norazmi Mohd Nor, Maryam Azlan, and Frank Camacho. "The Use of Adeno-associated virus (AAV) in Vaccine Development." Asian Journal of Medicine and Biomedicine 6, S1 (November 10, 2022): 192–93. http://dx.doi.org/10.37231/ajmb.2022.6.s1.583.
Повний текст джерелаGonçalves, Manuel A. F. V., Ietje van der Velde, Josephine M. Janssen, Bram T. H. Maassen, Evert H. Heemskerk, Dirk-Jan E. Opstelten, Shoshan Knaän-Shanzer, Dinko Valerio, and Antoine A. F. de Vries. "Efficient Generation and Amplification of High-Capacity Adeno-Associated Virus/Adenovirus Hybrid Vectors." Journal of Virology 76, no. 21 (November 1, 2002): 10734–44. http://dx.doi.org/10.1128/jvi.76.21.10734-10744.2002.
Повний текст джерелаFavaro, Patricia, Harre D. Downey, Federico Mingozzi, Fraser Wright, Bernd Hauck, Katherine A. High, and Valder R. Arruda. "Safety of Recombinant Adeno-Associated Viral Vectors in a Large Animal Model." Blood 110, no. 11 (November 16, 2007): 2586. http://dx.doi.org/10.1182/blood.v110.11.2586.2586.
Повний текст джерелаYan, Ziying, Roman Zak, Yulong Zhang, and John F. Engelhardt. "Inverted Terminal Repeat Sequences Are Important for Intermolecular Recombination and Circularization of Adeno-Associated Virus Genomes." Journal of Virology 79, no. 1 (January 1, 2005): 364–79. http://dx.doi.org/10.1128/jvi.79.1.364-379.2005.
Повний текст джерелаMingozzi, Federico, Jörg Schüttrumpf, Valder R. Arruda, Yuhong Liu, Yi-Lin Liu, Katherine A. High, Weidong Xiao, and Roland W. Herzog. "Improved Hepatic Gene Transfer by Using an Adeno-Associated Virus Serotype 5 Vector." Journal of Virology 76, no. 20 (October 15, 2002): 10497–502. http://dx.doi.org/10.1128/jvi.76.20.10497-10502.2002.
Повний текст джерелаHanazono, Yutaka, Kevin E. Brown, Atsushi Handa, Mark E. Metzger, Dominik Heim, Gary J. Kurtzman, Robert E. Donahue, and Cynthia E. Dunbar. "In Vivo Marking of Rhesus Monkey Lymphocytes by Adeno-Associated Viral Vectors: Direct Comparison With Retroviral Vectors." Blood 94, no. 7 (October 1, 1999): 2263–70. http://dx.doi.org/10.1182/blood.v94.7.2263.419k36_2263_2270.
Повний текст джерелаJewell, Andrew P., Melanie Cochrane, Jenny McIntosh, Reuben Benjamin, and Amit Nathwani. "Comparison of Viral Vectors for Gene Transfer into CLL Cells: Efficient Transduction with Adeno-Associated Virus-8 (AAV-8)." Blood 106, no. 11 (November 16, 2005): 2985. http://dx.doi.org/10.1182/blood.v106.11.2985.2985.
Повний текст джерелаMonahan, Paul E., Claude Négrier, Michael Tarantino, Leonard A. Valentino, and Federico Mingozzi. "Emerging Immunogenicity and Genotoxicity Considerations of Adeno-Associated Virus Vector Gene Therapy for Hemophilia." Journal of Clinical Medicine 10, no. 11 (June 2, 2021): 2471. http://dx.doi.org/10.3390/jcm10112471.
Повний текст джерелаДисертації з теми "Adeno-Associated Viral (AAV) vectors"
Lauramore, Amanda K. "Retinal cell tropism of adeno-associated viral (aav) vector serotypes." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0005301.
Повний текст джерелаTypescript. Title from title page of source document. Document formatted into pages; contains 71 pages. Includes Vita. Includes bibliographical references.
Choudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/809.
Повний текст джерелаChoudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/809.
Повний текст джерелаSteines, Benjamin Richard. "Investigation and application of novel adeno-associated viral vectors for cystic fibrosis gene therapy." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1763.
Повний текст джерелаIbraheim, Raed R. "Genome Engineering Goes Viral: Repurposing of Adeno-associated Viral Vectors for CRISPR-mediated in Vivo Genome Engineering." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1114.
Повний текст джерелаMoimas, Silvia. "A gene transfer approach, based on Adeno-Associated Viral (AAV) vectors, to study the process of vessel maturation and stabilization." Doctoral thesis, Università degli studi di Trieste, 2009. http://hdl.handle.net/10077/3311.
Повний текст джерелаThe main goal of angiogenic gene therapy is the formation of functional new blood vessels adequate to restore blood flow in ischemic tissues. Angiogenesis is a complex process, consisting in the sprouting of new capillaries from pre-existing vessels to form an immature vascular network, which subsequently undergoes functional maturation and remodelling. Many factors are involved in this process and, among them, the VEGF family members are universally recognized as the key players. During my PhD I exploited gene transfer by vectors based on the Adeno-Associated Virus (AAV) to express several factors involved in the angiogenic process, in an attempt to define the molecular and cellular mechanisms of vessel maturation and stabilization. Most experiments were performed by vector injection in the mouse and rat skeletal muscle, followed by detailed histological, immunohistochemical and functional analysis. First of all the angiogenic effect driven by two main VEGF isoforms, VEGF165 and VEGF121 was compared. AAV-VEGF165 and AAV-VEGF121 appeared equally able to induce endothelial cell proliferation, leading to the formation of new CD31 positive capillaries. However, only the longest VEGF165 isoform was capable to recruit -SMA positive cells around growing capillaries and therefore giving rise to small arteries. The acquisition of a smooth muscle cell layer can be considered as marker of vessel maturation. This was also confirmed by a permeability assay, which showed that VEGF121-induced vessels were more permeable compared to those induced by VEGF165. Interestingly, the presence of -SMA positive vessels was paralleled by the recruitment of CD11b positive mononuclear cells from the bone marrow, cells which were not recruited by VEGF121. The presence of these infiltrating cells in close proximity to the newly formed arterioles suggested their possible role in smooth muscle cell recruitment and vessel maturation. Real-time PCR allowed observing that the infiltrating CD11b positive cells expressed a cocktail of cytokines implicated in vessel maturation, such as TGF- and PDGF-B. As a proof of concept of the paracrine activity of these cells in vessel maturation, we developed an AAV-PDGF-B vector, which, when co-injected with AAV-VEGF121, was arteriogenic even in absence of cellular infiltration. Thus, the expression of PDGF-B partially substitutes for the cells observed in the muscles injected by AAV-VEGF165 to form arterial vessels. To verify the functionality of the vessels induced by AAV-VEGF165 we delivered this vector to different animal models of tissue ischemia: a flap ischemia model and an in vivo chamber for tissue engineering based on an artero-venous loop. In both the models, VEGF165 expression induced the formation of -SMA positive vessels, which turned out to improve flap survival in the flap models, and to promote the formation of new vascularized tissue in the chamber. Despite the presence of several arteries, other vessels formed by VEGF165 were abnormally enlarged and leaky, often forming vascular lacunae. This observation indicated that VEGF gene transfer might not be sufficient for the formation of a fully functional vascular network, and that other factors might be required in order to achieve functional competence of the neovessels. We observed that the combined expression of VEGF165 with Angiopoietin-1, which is known to stabilize endothelial and mural cell interactions, resulted in a significant reduction of vessel permeability and improved blood flow, as assessed by positron emission tomography (PET) and single photon emission tomography (SPECT). These findings reveal that a fine control of the expression of angiogenic factors is needed to achieve the formation of stable and functional vessels. The presence of -SMA positive cells might be considered as a first step in vessel maturation but further stabilization factors have to take part to the process in order to tighten the cell-cell junctions. Moreover, we showed that a detailed histological and functional analysis ex vivo might not be sufficient to characterized the new vasculature, requiring imaging techniques such as PET or SPECT.
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Ruozi, Giulia. "An in vivo functional selection strategy to identify novel genes sustaining cardiac function." Doctoral thesis, Scuola Normale Superiore, 2012. http://hdl.handle.net/11384/85943.
Повний текст джерелаXu, Dan. "Cellular Immunity in Recombinant Adeno-Associated Virus Vector Mediated Gene Therapy." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313504203.
Повний текст джерелаCarty, Nikisha Christine. "Recombinant AAV Gene Therapy and Delivery." Scholar Commons, 2009. https://scholarcommons.usf.edu/etd/1890.
Повний текст джерелаPacouret, Simon. "Thermostability of Adeno-Associated Virus (AAV) Vectors." Thesis, Nantes, 2018. http://www.theses.fr/2018NANT1041/document.
Повний текст джерелаAdeno-associated virus (AAV) vectors have emerged as promising gene delivery vehicles for gene therapy. To improve the probability of success of AAV-based therapeutic strategies, efforts are currently being made to engineer novel capsids able to produce and purify well, escape pre-existing immunity, and target specific cell populations more efficiently. One challenge in AAV vector engineering is to understand how to confer new functions to the viral capsid without altering its structural integrity. To do so, there is a critical need to gain further knowledge on the mechanisms steering AAV capsid metastability. The objective of this thesis is to investigate the thermal stability of AAVs, its impact on AAV biology, and applications to quality control of AAV preparations. First, we extend existing thermal stability studies to in silico reconstructed ancestral AAV particles (AncAAVs), and show that, Anc80, the common putative ancestor of AAV1, 2, 8 and 9, is 15-20°C more thermostable than its contemporary homologs. Using phenotype-tophylogeny mapping, we also identify a set of 12 residues potentially playing a key role in capsid metastability. Second, we demonstrate that capsid thermal stability, as measured by Differential Scanning Fluorimetry (DSF), can be used for identification of AAV preparations at the protein level, a requirement of regulatory agencies. Last, we apply this identity assay to the study of capsid mosaic formation in AAV library preparations. This work will help guide the engineering and manufacturing of improved AAV vectors for gene therapy
Книги з теми "Adeno-Associated Viral (AAV) vectors"
Berns, Kenneth I., and Catherine Giraud, eds. Adeno-Associated Virus (AAV) Vectors in Gene Therapy. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-80207-2.
Повний текст джерелаAdeno-Associated Virus (Aav) Vectors in Gene Therapy. Springer-Verlag Telos, 1996.
Знайти повний текст джерелаGiraud, Catherine, and Kenneth I. Berns. Adeno-Associated Virus (AAV) Vectors in Gene Therapy. Springer London, Limited, 2012.
Знайти повний текст джерелаAdeno-Associated Viral Vectors for Gene Therapy. Elsevier, 2005. http://dx.doi.org/10.1016/s0075-7535(05)x1016-6.
Повний текст джерелаAdeno-Associated Virus (Aav): Vectors in Gene Therapy (Current Topics in Microbiology and Immunology). Springer-Verlag, 1996.
Знайти повний текст джерелаMuzyczka, Nicholas. Viral Expression Vectors (Current Topics in Microbiology and Immunology). Springer, 1992.
Знайти повний текст джерелаBiloshytsky, Vadym, and Roman Cregg. Pioneering use of gene therapy for pain. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0083.
Повний текст джерелаЧастини книг з теми "Adeno-Associated Viral (AAV) vectors"
Blessing, Daniel, Nicole Déglon, and Bernard L. Schneider. "Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV)." In Methods in Molecular Biology, 259–74. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8730-6_17.
Повний текст джерелаFakhiri, Julia, Manuela Nickl, and Dirk Grimm. "Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors." In Methods in Molecular Biology, 111–26. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9170-9_8.
Повний текст джерелаPatrício, Maria I., and Robert E. MacLaren. "Retinal Gene Therapy for Choroideremia: In Vitro Testing for Gene Augmentation Using an Adeno-Associated Viral (AAV) Vector." In Retinal Gene Therapy, 89–97. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7522-8_7.
Повний текст джерелаGuiner, Caroline Le, Phillipe Moullier, and Valder R. Arruda. "Biodistribution and Shedding of AAV Vectors." In Adeno-Associated Virus, 339–59. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-370-7_15.
Повний текст джерелаGray, John T., and Serge Zolotukhin. "Design and Construction of Functional AAV Vectors." In Adeno-Associated Virus, 25–46. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-370-7_2.
Повний текст джерелаSamulski, Richard Jude. "Adeno-associated Viral Vectors." In Viruses in Human Gene Therapy, 53–76. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0555-2_3.
Повний текст джерелаde Backer, Marijke W. A., Keith M. Garner, Mieneke C. M. Luijendijk, and Roger A. H. Adan. "Recombinant Adeno-Associated Viral Vectors." In Methods in Molecular Biology, 357–76. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-310-3_24.
Повний текст джерелаHallek, M., C. M. Wendtner, R. Kotin, D. Michl, and E. L. Winnacker. "Recombinant Adeno-Associated Virus (r AAV) Vectors." In Gene Therapy, 73–91. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-7011-5_6.
Повний текст джерелаBerns, K. I., and C. Giraud. "Biology of Adeno-associated Virus." In Adeno-Associated Virus (AAV) Vectors in Gene Therapy, 1–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-80207-2_1.
Повний текст джерелаGao, Guangping, Li Zhong, and Olivier Danos. "Exploiting Natural Diversity of AAV for the Design of Vectors with Novel Properties." In Adeno-Associated Virus, 93–118. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-370-7_4.
Повний текст джерелаТези доповідей конференцій з теми "Adeno-Associated Viral (AAV) vectors"
Dombrowski, T., A. Dieter, V. Rankovic, M. Jeschke, and T. Moser. "Optogenetic modification of the auditory nerve with adeno-associated viral vectors." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640292.
Повний текст джерелаJheel, Pandya, Kellee Britt, and George Aslanidi. "Abstract 714: Bioengineering of the adeno-associated virus (AAV) vectors for dendritic cell (DC)-based immunotherapy." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-714.
Повний текст джерелаSharma, Satish K., Blerina Ducka, Imre G. Redai, Zhilong Jiang, Akshit R. Gupta, Cynthia Koziol-White, Ru Xiao, James Wilson, Maria Limberis, and Angela Haczku. "Adeno-Associated Viral (AAV)-Surfactant Protein D (SP-D)-Gene Treatment Rescued The Pulmonary Innate Immune Cell Abnormalities In SP-D-/- Mice." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1057.
Повний текст джерела