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Статті в журналах з теми "Adenine-sensing"

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Автор: Grafiati

Опубліковано: 14 березня 2023

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1

Jesny, S., Shalini Menon, and K. Girish Kumar. "Simultaneous determination of guanine and adenine in the presence of uric acid by a poly(para toluene sulfonic acid) mediated electrochemical sensor in alkaline medium." RSC Advances 6, no. 79 (2016): 75741–48. http://dx.doi.org/10.1039/c6ra13567f.

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2

Zhang, Ningzi, Diwei Zhang, Jing Zhao, and Zhiguo Xia. "Fabrication of a dual-emitting dye-encapsulated metal–organic framework as a stable fluorescent sensor for metal ion detection." Dalton Transactions 48, no. 20 (2019): 6794–99. http://dx.doi.org/10.1039/c9dt01125k.

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3

Barman, Koushik, and Sk Jasimuddin. "Electrochemical detection of adenine and guanine using a self-assembled copper(ii)–thiophenyl-azo-imidazole complex monolayer modified gold electrode." RSC Adv. 4, no. 91 (2014): 49819–26. http://dx.doi.org/10.1039/c4ra08568j.

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4

Rawat, Karuna A., and Suresh Kumar Kailasa. "2,3,4-Trihydroxy benzophenone as a novel reducing agent for one-step synthesis of size-optimized gold nanoparticles and their application in colorimetric sensing of adenine at nanomolar concentration." RSC Advances 6, no. 14 (2016): 11099–108. http://dx.doi.org/10.1039/c5ra21634f.

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5

Wickiser, J. Kenneth, Ming T. Cheah, Ronald R. Breaker, and Donald M. Crothers. "The Kinetics of Ligand Binding by an Adenine-Sensing Riboswitch." Biochemistry 44, no. 40 (October 2005): 13404–14. http://dx.doi.org/10.1021/bi051008u.

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6

Fan, Yang, Ke-Jing Huang, De-Jun Niu, Chun-Peng Yang, and Qiang-Shan Jing. "TiO2-graphene nanocomposite for electrochemical sensing of adenine and guanine." Electrochimica Acta 56, no. 12 (April 2011): 4685–90. http://dx.doi.org/10.1016/j.electacta.2011.02.114.

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7

Warhaut, Sven, Klara Rebecca Mertinkus, Philipp Höllthaler, Boris Fürtig, Mike Heilemann, Martin Hengesbach, and Harald Schwalbe. "Ligand-Directed Conformational Dynamics of the Adenine-Sensing Riboswitch Thermostat." Biophysical Journal 112, no. 3 (February 2017): 368a. http://dx.doi.org/10.1016/j.bpj.2016.11.1996.

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8

von Ketteler, Alexa, Dirk-Peter Herten, and Wolfgang Petrich. "Fluorescence Properties of Carba Nicotinamide Adenine Dinucleotide for Glucose Sensing." ChemPhysChem 13, no. 5 (February 15, 2012): 1302–6. http://dx.doi.org/10.1002/cphc.201100921.

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9

Xue, Yanyan, and Yu Liu. "Incorporation of a FRET Pair into a Riboswitch RNA to Measure Mg2+ Concentration and RNA Conformational Change in Cell." International Journal of Molecular Sciences 23, no. 3 (January 27, 2022): 1493. http://dx.doi.org/10.3390/ijms23031493.

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Анотація:

Riboswitches are natural biosensors that can regulate gene expression by sensing small molecules. Knowledge of the structural dynamics of riboswitches is crucial to elucidate their regulatory mechanism and develop RNA biosensors. In this work, we incorporated the fluorophore, Cy3, and its quencher, TQ3, into a full-length adenine riboswitch RNA and its isolated aptamer domain to monitor the dynamics of the RNAs in vitro and in cell. The adenine riboswitch was sensitive to Mg2+ concentrations and could be used as a biosensor to measure cellular Mg2+ concentrations. Additionally, the TQ3/Cy3-labeled adenine riboswitch yielded a Mg2+ concentration that was similar to that measured using a commercial assay kit. Furthermore, the fluorescence response to the adenine of the TQ3/Cy3-labeled riboswitch RNA was applied to determine the proportions of multiple RNA conformational changes in cells. The strategy developed in this work can be used to probe the dynamics of other RNAs in cells and may facilitate the developments of RNA biosensors, drugs and engineering.

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10

Dey, Sourav Kumar, Grigory S. Filonov, Anthony O. Olarerin-George, Benjamin T. Jackson, Lydia W. S. Finley, and Samie R. Jaffrey. "Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag." Nature Chemical Biology 18, no. 2 (December 22, 2021): 180–90. http://dx.doi.org/10.1038/s41589-021-00925-0.

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11

Gu, Xin, Yan Yan, Scott J. Novick, Amanda Kovach, Devrishi Goswami, Jiyuan Ke, M. H. Eileen Tan, et al. "Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing." Journal of Biological Chemistry 292, no. 30 (June 14, 2017): 12653–66. http://dx.doi.org/10.1074/jbc.m117.793018.

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12

Yu, Kuan-Kun, Wei-Bin Tseng, Man-Jyun Wu, A. Santhana Krishna Kumar Alagarsamy, Wei-Lung Tseng, and Po-Chiao Lin. "Polyadenosine-based fluorescent probe for reversible pH sensing based on protonated adenine-adenine base pairs: Applications to sensing of enzyme-substrate system and enzymatic logic gates." Sensors and Actuators B: Chemical 273 (November 2018): 681–88. http://dx.doi.org/10.1016/j.snb.2018.06.116.

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13

Liu, Xiaoqin, Buhai Li, and Chunya Li. "Sensitive determination of dihydronicotinamide adenine dinucleotide and ethanol with a nano-porous carbon electrode." Journal of the Serbian Chemical Society 76, no. 1 (2011): 113–23. http://dx.doi.org/10.2298/jsc100127007l.

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Анотація:

A nano-porous carbon electrode, fabricated in 0.1 mol L?1 NaOH by the electrochemical technique, was used for the electrochemical detection of dihydronicotinamide adenine dinucleotide, NADH, with an overpotential decrease of about 270 mV and a linear range from 1.0 ? 10?6 to 1.0 ? 10?4 mol L?1. Amperometric sensing of ethanol cooperating with alcohol dehydrogenase and nicotinamide adenine dinucleotide was successfully demonstrated. A linear response in the range from 5.0 ? 10?5 mol L?1 to 1.0 ? 10?2 mol L?1 was obtained, with a detection limit of 1.0 ? 10?5 mol L?1. The method was successfully employed to determine ethanol in beer with high precision.

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14

Bagherolhashemi, Fateme, Mohammad Reza Bozorgmehr, and Mohammad Momen-Heravi. "Effect of Lysyllysine on non-covalent hybridization of single walled carbon nanotube by single-stranded DNA homodimer: in silico approach." Journal of Nanostructure in Chemistry 9, no. 4 (November 7, 2019): 315–21. http://dx.doi.org/10.1007/s40097-019-00320-1.

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Abstract In this work, the interactions between adenine–adenine di-nucleotide (DA2N) and carbon nanotube (CNT) in the presence of Lysyllysine (LL) was studied by the molecular dynamics simulation. Different carbon nanotubes including (5.5), (6.6) and (7.7) were used to investigate the effect of CNT type. The binding energies were calculated using the molecular mechanics-Poisson Bolzmann surface area method. The results showed that the contribution of the van der Waals interactions between DA2N and CNT was greater than that of the electrostatic interactions. The LL significantly enhanced the electrostatic interactions between the DA2N and CNT (6.6). The quantum calculations revealed that the sensor properties of the DA2N were not significantly affected by the CNT and LL. However, the five-membered ring of adenine played a more important role in the sensing properties of the DA2N. The obtained results are consistent with the previous experimental observations that can help to understand the molecular mechanism of the interaction of DA2N with CNT. Graphic abstract

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15

Allner, O., L. Nilsson, and A. Villa. "Loop-loop interaction in an adenine-sensing riboswitch: A molecular dynamics study." RNA 19, no. 7 (May 28, 2013): 916–26. http://dx.doi.org/10.1261/rna.037549.112.

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16

Keller, Heiko, A. Katharina Weickhmann, Thomas Bock, and Jens Wöhnert. "Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches." RNA 24, no. 10 (July 13, 2018): 1390–402. http://dx.doi.org/10.1261/rna.067470.118.

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17

Amouzadeh Tabrizi, Mahmoud, Somayeh Jalilzadeh Azar, and Javad Nadali Varkani. "Eco-synthesis of graphene and its use in dihydronicotinamide adenine dinucleotide sensing." Analytical Biochemistry 460 (September 2014): 29–35. http://dx.doi.org/10.1016/j.ab.2014.05.002.

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18

Liu, Yang, Yong-Lan Feng, and Wei-Wei Fu. "A new two-dimensional extended adenine and thiophenecarboxylate mixed-ligand zinc(II) complex: synthesis, structure, thermostability and luminescent properties." Acta Crystallographica Section C Structural Chemistry 71, no. 12 (November 12, 2015): 1069–73. http://dx.doi.org/10.1107/s2053229615021221.

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Анотація:

The design and preparation of crystalline polymeric materials has attracted increasing attention due to their diverse applications as functional materials in gas storage, separation, catalysis, sensing and photoluminescence. The judicious selection of organic linkers is critical for varying the coordination behaviour of the metal ions and determining the overall characteristics of the networks. A new adenine-based ZnIIcoordination polymer, [Zn(C6H2O4S)(C5H5N5)]nor [Zn(tdc)(9H-ade)] (H2tdc is thiophene-2,5-dicarboxylic acid and ade is adenine), has been prepared hydrothermally and the crystal structure exhibits in its packing two-dimensional (4,4) grid sheets parallel to theabplane, featuring two distinct square cavities delimited by the two types of ligands and the ZnIIions with the dimensions 6.6 × 6.6 and 10.2 × 10.2 Å (based on the Zn...Zn distance). The title complex shows enhanced photoluminescence at 378 nm compared to the free ligands, suggesting that the coordination of H2tdc or adenine to the metal centre effectively increases the rigidity of the ligands and reduces the energy loss by radiative decay of intraligand excited states.

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19

Wang, Zhuo, Yanxin Yu, Deqing Zhang, and Daoben Zhu. "Thymine and adenine derivatives with pyrene, tetrathiafulvalene and nitronyl nitroxide units: Synthesis and formation of ensembles sensing thymine and adenine molecules." Chinese Science Bulletin 51, no. 16 (August 2006): 1947–54. http://dx.doi.org/10.1007/s11434-006-2046-8.

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20

Dey, Sourav Kumar, Grigory S. Filonov, Anthony O. Olarerin-George, Benjamin T. Jackson, Lydia W. S. Finley, and Samie R. Jaffrey. "Publisher Correction: Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag." Nature Chemical Biology 18, no. 2 (January 21, 2022): 236. http://dx.doi.org/10.1038/s41589-022-00969-w.

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21

Hui, Yuchen, Xiaoyan Ma, Xiuzhang Hou, Fang Chen та Jie Yu. "Silver nanoparticles-β-cyclodextrin-graphene nanocomposites based biosensor for guanine and adenine sensing". Ionics 21, № 6 (18 грудня 2014): 1751–59. http://dx.doi.org/10.1007/s11581-014-1343-5.

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22

Li, Junhua, Jianbo Jiang, Haibo Feng, Zhifeng Xu, Siping Tang, Peihong Deng, and Dong Qian. "Facile synthesis of 3D porous nitrogen-doped graphene as an efficient electrocatalyst for adenine sensing." RSC Advances 6, no. 37 (2016): 31565–73. http://dx.doi.org/10.1039/c6ra01864e.

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23

Francis, Shijo, and Leena Rajith. "Selective Fluorescent Sensing of Adenine Via the Emissive Enhancement of a Simple Cobalt Porphyrin." Journal of Fluorescence 31, no. 2 (January 22, 2021): 577–86. http://dx.doi.org/10.1007/s10895-021-02685-5.

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24

Martin, Jessica L., Phillip A. Yates, Jan M. Boitz, Dennis R. Koop, Audrey L. Fulwiler, Maria Belen Cassera, Buddy Ullman, and Nicola S. Carter. "A role for adenine nucleotides in the sensing mechanism to purine starvation inLeishmania donovani." Molecular Microbiology 101, no. 2 (May 3, 2016): 299–313. http://dx.doi.org/10.1111/mmi.13390.

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25

Serganov, Alexander, Yu-Ren Yuan, Olga Pikovskaya, Anna Polonskaia, Lucy Malinina, Anh Tuân Phan, Claudia Hobartner, Ronald Micura, Ronald R. Breaker, and Dinshaw J. Patel. "Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAs." Chemistry & Biology 11, no. 12 (December 2004): 1729–41. http://dx.doi.org/10.1016/j.chembiol.2004.11.018.

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26

Ortolani, Túlio S., Tamires S. Pereira, Mônica H. M. T. Assumpção, Fernando C. Vicentini, Geiser Gabriel de Oliveira, and Bruno C. Janegitz. "Electrochemical sensing of purines guanine and adenine using single-walled carbon nanohorns and nanocellulose." Electrochimica Acta 298 (March 2019): 893–900. http://dx.doi.org/10.1016/j.electacta.2018.12.114.

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27

Karthikeyan, B., and M. Murugavelu. "Nano bimetallic Ag/Pt system as efficient opto and electrochemical sensing platform towards adenine." Sensors and Actuators B: Chemical 163, no. 1 (March 2012): 216–23. http://dx.doi.org/10.1016/j.snb.2012.01.039.

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28

St-Pierre, Patrick, Euan Shaw, Samuel Jacques, Paul A. Dalgarno, Cibran Perez-Gonzalez, Frédéric Picard-Jean, J. Carlos Penedo, and Daniel A. Lafontaine. "A structural intermediate pre-organizes the add adenine riboswitch for ligand recognition." Nucleic Acids Research 49, no. 10 (May 8, 2021): 5891–904. http://dx.doi.org/10.1093/nar/gkab307.

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Анотація:

Abstract Riboswitches are RNA sequences that regulate gene expression by undergoing structural changes upon the specific binding of cellular metabolites. Crystal structures of purine-sensing riboswitches have revealed an intricate network of interactions surrounding the ligand in the bound complex. The mechanistic details about how the aptamer folding pathway is involved in the formation of the metabolite binding site have been previously shown to be highly important for the riboswitch regulatory activity. Here, a combination of single-molecule FRET and SHAPE assays have been used to characterize the folding pathway of the adenine riboswitch from Vibrio vulnificus. Experimental evidences suggest a folding process characterized by the presence of a structural intermediate involved in ligand recognition. This intermediate state acts as an open conformation to ensure ligand accessibility to the aptamer and folds into a structure nearly identical to the ligand-bound complex through a series of structural changes. This study demonstrates that the add riboswitch relies on the folding of a structural intermediate that pre-organizes the aptamer global structure and the ligand binding site to allow efficient metabolite sensing and riboswitch genetic regulation.

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29

Noeske, J., H. Schwalbe, and J. Wohnert. "Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain." Nucleic Acids Research 35, no. 15 (July 11, 2007): 5262–73. http://dx.doi.org/10.1093/nar/gkm565.

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30

Wang, Kun, Jun Wu, Qian Liu, Yicong Jin, Jiajia Yan, and Jianrong Cai. "Ultrasensitive photoelectrochemical sensing of nicotinamide adenine dinucleotide based on graphene-TiO2 nanohybrids under visible irradiation." Analytica Chimica Acta 745 (October 2012): 131–36. http://dx.doi.org/10.1016/j.aca.2012.07.042.

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31

Anithaa, A. C., K. Asokan, N. Lavanya, and C. Sekar. "Nicotinamide adenine dinucleotide immobilized tungsten trioxide nanoparticles for simultaneous sensing of norepinephrine, melatonin and nicotine." Biosensors and Bioelectronics 143 (October 2019): 111598. http://dx.doi.org/10.1016/j.bios.2019.111598.

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32

Wu, Min, Ye Feng, Guo-Xin Ye, Yu-Chen Han, Si-Si Wang, Hai-Feng Ni, Feng-Mei Wang, Min Gao, Lin-Li Lv, and Bi-Cheng Liu. "Calcium-sensing receptor activation attenuates collagen expression in renal proximal tubular epithelial cells." American Journal of Physiology-Renal Physiology 316, no. 5 (May 1, 2019): F1006—F1015. http://dx.doi.org/10.1152/ajprenal.00413.2018.

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Анотація:

316: F1006–F1015, 2019. First published March 6, 2019; doi: 10.1152/ajprenal.00413.2018 .—Experimental studies have shown that pharmacological activation of calcium-sensing receptor (CaSR) attenuates renal fibrosis in some animal models beyond modification of bone and mineral homeostasis; however, its underlying mechanisms remain largely unknown. Since excessive collagen deposition is the key feature of fibrosis, the present study aimed to examine whether CaSR was involved in the regulation of collagen expression in rats with adenine diet-induced renal fibrosis and in profibrotic transforming growth factor (TGF)-β1-treated renal proximal tubular epithelial cells (PTECs). The results showed that the CaSR agonist cinacalcet significantly attenuated renal collagen accumulation and tubular injury in adenine diet-fed rats. Additionally, the in vitro experiment showed that profibrotic TGF-β1 significantly increased the expression of collagen and decreased CaSR expression at the mRNA and protein levels in a concentration- and time-dependent manner. Furthermore, the CaSR CRISPR activation plasmid and cinacalcet partially abrogated the upregulation of collagen induced by TGF-β1 treatment. Blockade of CaSR by the CRISPR/Cas9 KO plasmid or the pharmacological antagonist Calhex231 further enhanced TGF-β1-induced collagen expression. Mechanistic experiments found that Smad2 phosphorylation and Snail expression were markedly increased in PTECs treated with TGF-β1, whereas the CaSR CRISPR activation plasmid and cinacalcet substantially suppressed this induction. In summary, this study provides evidence for a direct renal tubular epithelial protective effect of CaSR activation in renal fibrosis, possibly through suppression of collagen expression in PTECs.

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33

Dunham-Snary, Kimberly J., Danchen Wu, François Potus, Edward A. Sykes, Jeffrey D. Mewburn, Rebecca L. Charles, Philip Eaton, Richard A. Sultanian, and Stephen L. Archer. "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction." Circulation Research 124, no. 12 (June 7, 2019): 1727–46. http://dx.doi.org/10.1161/circresaha.118.314284.

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Rationale: Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary artery smooth muscle cells (PASMCs). Hypoxia dilates systemic arteries, including renal arteries. Hypoxia is sensed by changes in mitochondrial-derived reactive oxygen species, notably hydrogen peroxide (H 2 O 2 ) ([H 2 O 2 ] mito ). Decreases in [H 2 O 2 ] mito elevate pulmonary vascular tone by increasing intracellular calcium ([Ca 2+ ] i ) through reduction-oxidation regulation of ion channels. Although HPV is mimicked by the Complex I inhibitor, rotenone, the molecular identity of the O 2 sensor is unknown. Objective: To determine the role of Ndufs2 (NADH [nicotinamide adenine dinucleotide] dehydrogenase [ubiquinone] iron-sulfur protein 2), Complex I’s rotenone binding site, in pulmonary vascular oxygen-sensing. Methods and Results: Mitochondria-conditioned media from pulmonary and renal mitochondria isolated from normoxic and chronically hypoxic rats were infused into an isolated lung bioassay. Mitochondria-conditioned media from normoxic lungs contained more H 2 O 2 than mitochondria-conditioned media from chronic hypoxic lungs or kidneys and uniquely attenuated HPV via a catalase-dependent mechanism. In PASMC, acute hypoxia decreased H 2 O 2 within 112±7 seconds, followed, within 205±34 seconds, by increased intracellular calcium concentration, [Ca 2+ ] i . Hypoxia had no effects on [Ca 2+ ] i in renal artery SMC. Hypoxia decreases both cytosolic and mitochondrial H 2 O 2 in PASMC while increasing cytosolic H 2 O 2 in renal artery SMC. Ndufs2 expression was greater in PASMC versus renal artery SMC. Lung Ndufs2 cysteine residues became reduced during acute hypoxia and both hypoxia and reducing agents caused functional inhibition of Complex I. In PASMC, siNdufs2 (cells/tissue treated with Ndufs2 siRNA) decreased normoxic H 2 O 2 , prevented hypoxic increases in [Ca 2+ ] i , and mimicked aspects of chronic hypoxia, including decreasing Complex I activity, elevating the nicotinamide adenine dinucleotide (NADH/NAD + ) ratio and decreasing expression of the O 2 -sensitive ion channel, Kv1.5. Knocking down another Fe-S center within Complex I (Ndufs1, NADH [nicotinamide adenine dinucleotide] dehydrogenase [ubiquinone] iron-sulfur protein 1) or other mitochondrial subunits proposed as putative oxygen sensors (Complex III’s Rieske Fe-S center and COX4i2 [cytochrome c oxidase subunit 4 isoform 2] in Complex IV) had no effect on hypoxic increases in [Ca 2+ ] i . In vivo, siNdufs2 significantly decreased hypoxia- and rotenone-induced constriction while enhancing phenylephrine-induced constriction. Conclusions: Ndufs2 is essential for oxygen-sensing and HPV.

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34

Sedghiniya, Sima, Janet Soleimannejad, Zohreh Jahani, Jamshid Davoodi, and Jan Janczak. "Crystal engineering of an adenine–decavanadate molecular device towards label-free chemical sensing and biological screening." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 76, no. 1 (January 24, 2020): 85–92. http://dx.doi.org/10.1107/s2052520619016196.

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Анотація:

Due to the inherent geometrical interdependencies of nucleic acid structures, the ability to engineer biosensors that rely on the specific interactions of these compounds is of considerable importance. Additionally, sensing or screening in a label-free fashion is a capability of these structures that can be readily achieved by exploiting the fluorescent component. In this work, the [AdH]6[V10O28].4(H2O) (1) supramolecular structure is introduced using adenine and decavanadate moieties that allow probing of selectivity to specific nucleic acid binding events by optical changes. The structure of (1) is an alternating organic–inorganic hybrid architecture of cationic adeninium (AdH+) ribbons and anionic decavanadate (DV)–water sheets. The luminescent screening and anticancer activity of compound (1) on the two human mammary carcinoma cell lines MDA-MB-231 and MCF7 were investigated using fluorescent microscopy and MTT assays, respectively. It was found that compound (1) is cell permeable with no toxicity below 12.5 µM concentration and moderate cytotoxicity at concentrations as high as 200 µM in human breast cancer cell lines, making it a useful tool to study the cell nucleus in real time.

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35

Liu, Yang, Shi‐Ting Zhang, Yan‐Bin Wu, Wei Li, and Ying‐Qun Yang. "A 3D Adenine‐based Cd‐MOF: Synthesis, Structure and Photoluminescent Sensing for an Aromatic Azo Compound." Zeitschrift für anorganische und allgemeine Chemie 646, no. 23-24 (November 9, 2020): 1911–15. http://dx.doi.org/10.1002/zaac.202000303.

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36

Xi, Mengying, Yuanyuan Duan, Xia Li, Lining Qu, Wei Sun, and Kui Jiao. "Carbon electrode modified with ionic liquid and multi-walled carbon nanotubes for voltammetric sensing of adenine." Microchimica Acta 170, no. 1-2 (May 27, 2010): 53–58. http://dx.doi.org/10.1007/s00604-010-0371-8.

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37

TSUCHIYA, Akira, Siti N. HASHIM, Shoko ISE, Takafumi FURUHATA, Kiyohiko KAWAI, Rie WAKABAYASHI, Masahiro GOTO, Noriho KAMIYA, and Shinsuke SANDO. "BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells." Analytical Sciences 32, no. 5 (2016): 543–47. http://dx.doi.org/10.2116/analsci.32.543.

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38

Wang, Yue, and Yasushi Hasebe. "Phenazine-dye- and Enzyme-modified Plastic Formed Carbon Electrode for Amperometric Dihydronicotinamide Adenine Dinucleotide and Glucose Sensing." Sensors and Materials 31, no. 4 (April 11, 2019): 1181. http://dx.doi.org/10.18494/sam.2019.2177.

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Zhu, Yongsheng, Xinling Tong, Haizhen Song, Yinhua Wang, Zhanping Qiao, Dongfang Qiu, Jinshu Huang, and Zhiwen Lu. "CsPbBr3 perovskite quantum dots/ZnO inverse opal electrodes: photoelectrochemical sensing for dihydronicotinamide adenine dinucleotide under visible irradiation." Dalton Transactions 47, no. 30 (2018): 10057–62. http://dx.doi.org/10.1039/c8dt01790e.

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All-inorganic perovskite quantum dots (PQDs) have attracted tremendous attention due to their extraordinary optical properties, especially CsPbBr₃ QDs with their high stability and photoluminescence efficiency.

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Mu, Yaxin, Qianfen Zhuang, Saipeng Huang, Mingyue Hu, Yong Wang, and Yongnian Ni. "Adenine-stabilized carbon dots for highly sensitive and selective sensing of copper(II) ions and cell imaging." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 239 (October 2020): 118531. http://dx.doi.org/10.1016/j.saa.2020.118531.

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Hisamatsu, Yosuke, Keiko Hasada, Fumi Amano, Yasuhiro Tsubota, Yuko Wasada-Tsutsui, Naohiro Shirai, Shin-ichi Ikeda, and Kazunori Odashima. "Highly Selective Recognition of Adenine Nucleobases by Synthetic Hosts with a Linked Five-Six-Five-Membered Triheteroaromatic Structure and the Application to Potentiometric Sensing of the Adenine Nucleotide." Chemistry - A European Journal 12, no. 29 (October 5, 2006): 7733–41. http://dx.doi.org/10.1002/chem.200600099.

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42

Franza, Thierry, Annika Rogstam, Saravanamuthu Thiyagarajan, Matthew J. Sullivan, Aurelie Derré-Bobillot, Mikael C. Bauer, Kelvin G. K. Goh, et al. "NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence." PLOS Pathogens 17, no. 8 (August 9, 2021): e1009791. http://dx.doi.org/10.1371/journal.ppat.1009791.

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In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/NAD+ ratio. Here, we report high-resolution crystal structures and characterization of a Rex ortholog (Gbs1167) in the opportunistic pathogen, Streptococcus agalactiae, also known as group B streptococcus (GBS). We present structures of Rex bound to NAD+ and to a DNA operator which are the first structures of a Rex-family member from a pathogenic bacterium. The structures reveal the molecular basis of DNA binding and the conformation alterations between the free NAD+ complex and DNA-bound form of Rex. Transcriptomic analysis revealed that GBS Rex controls not only central metabolism, but also expression of the monocistronic rex gene as well as virulence gene expression. Rex enhances GBS virulence after disseminated infection in mice. Mechanistically, NAD+ stabilizes Rex as a repressor in the absence of NADH. However, GBS Rex is unique compared to Rex regulators previously characterized because of its sensing mechanism: we show that it primarily responds to NAD+ levels (or growth rate) rather than to the NADH/NAD+ ratio. These results indicate that Rex plays a key role in GBS pathogenicity by modulating virulence factor gene expression and carbon metabolism to harvest nutrients from the host.

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Gutiérrez, Alejandro, Fabiana A. Gutierrez, Marcos Eguílaz, José M. González-Domínguez, Javier Hernández-Ferrer, Alejandro Ansón-Casaos, María T. Martínez, and Gustavo A. Rivas. "Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine." RSC Advances 6, no. 16 (2016): 13469–77. http://dx.doi.org/10.1039/c5ra22556f.

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Kumar, S. Ashok, Szu-Ling Chen, and Shen-Ming Chen. "Electrochemical Sensing of H[sub 2]O[sub 2] at Flavin Adenine Dinucleotide/Chitosan/CNT Nanocomposite Modified Electrode." Electrochemical and Solid-State Letters 13, no. 10 (2010): K83. http://dx.doi.org/10.1149/1.3463809.

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Xu, Zhaochao, N. Jiten Singh, Jeesun Lim, Jie Pan, Ha Na Kim, Sungsu Park, Kwang S. Kim, and Juyoung Yoon. "Unique Sandwich Stacking of Pyrene-Adenine-Pyrene for Selective and Ratiometric Fluorescent Sensing of ATP at Physiological pH." Journal of the American Chemical Society 131, no. 42 (October 28, 2009): 15528–33. http://dx.doi.org/10.1021/ja906855a.

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46

Yari, Abdollah, and Marzieh Saidikhah. "Trithiane silver-nanoparticles-decorated polyaniline nanofibers as sensing element for electrochemical determination of Adenine and Guanine in DNA." Journal of Electroanalytical Chemistry 783 (December 2016): 288–94. http://dx.doi.org/10.1016/j.jelechem.2016.10.063.

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47

Xu, Zhaochao, David R. Spring, and Juyoung Yoon. "Fluorescent Sensing and Discrimination of ATP and ADP Based on a Unique Sandwich Assembly of Pyrene-Adenine-Pyrene." Chemistry - An Asian Journal 6, no. 8 (April 19, 2011): 2114–22. http://dx.doi.org/10.1002/asia.201100120.

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Pati, Chiranjit, Rameez Raza, and Kumaresh Ghosh. "Adenine-linked naphthalimide: A case of selective colorimetric as well as fluorometric sensing of F− and anion-activated moisture detection in organic solvents and CO2-sensing." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 229 (March 2020): 117910. http://dx.doi.org/10.1016/j.saa.2019.117910.

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Lee, Ju Kyung, Han Na Suh, Sung Hoon Yoon, Kyu Hong Lee, Sae Young Ahn, Hyung Jin Kim, and Sang Hee Kim. "Non-Destructive Monitoring via Electrochemical NADH Detection in Murine Cells." Biosensors 12, no. 2 (February 10, 2022): 107. http://dx.doi.org/10.3390/bios12020107.

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Nicotinamide adenine dinucleotide (NADH) is an important cofactor involved in metabolic redox reactions in living cells. The detection of NADH in living animal cells is a challenge. We developed a one-step monitoring method for NADH via an electrocatalytic reaction that uses a surface-modified, screen-printed electrode (SPE) having a redox active monolayer 4′-mercapto-N-phenlyquinone diamine (NPQD) formed by a self-assembled monolayer (SAM) of an aromatic thiol, 4-aminothiophenol (4-ATP). This electrode has a limit of detection (LOD) of 0.49 μM and a sensitivity of 0.0076 ± 0.0006 μM/μA in cell culture media, which indicates that it retains its selectivity. The applicability of this NADH sensor was demonstrated for the first time by cell viability monitoring via NADH-sensing in cell culture supernatants.

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Bruce, Kimberley D., Evgenia Dobrinskikh, Hong Wang, Ivan Rudenko, Hong Gao, Andrew E. Libby, Sachi Gorkhali, Tian Yu, Andrea Zsombok, and Robert H. Eckel. "Neuronal Lipoprotein Lipase Deficiency Alters Neuronal Function and Hepatic Metabolism." Metabolites 10, no. 10 (September 28, 2020): 385. http://dx.doi.org/10.3390/metabo10100385.

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The autonomic regulation of hepatic metabolism offers a novel target for the treatment of non-alcoholic fatty liver disease (NAFLD). However, the molecular characteristics of neurons that regulate the brain-liver axis remain unclear. Since mice lacking neuronal lipoprotein lipase (LPL) develop perturbations in neuronal lipid-sensing and systemic energy balance, we reasoned that LPL might be a component of pre-autonomic neurons involved in the regulation of hepatic metabolism. Here, we show that, despite obesity, mice with reduced neuronal LPL (NEXCreLPLflox (LPL KD)) show improved glucose tolerance and reduced hepatic lipid accumulation with aging compared to wilt type (WT) controls (LPLflox). To determine the effect of LPL deficiency on neuronal physiology, liver-related neurons were identified in the paraventricular nucleus (PVN) of the hypothalamus using the transsynaptic retrograde tracer PRV-152. Patch-clamp studies revealed reduced inhibitory post-synaptic currents in liver-related neurons of LPL KD mice. Fluorescence lifetime imaging microscopy (FLIM) was used to visualize metabolic changes in LPL-depleted neurons. Quantification of free vs. bound nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) revealed increased glucose utilization and TCA cycle flux in LPL-depleted neurons compared to controls. Global metabolomics from hypothalamic cell lines either deficient in or over-expressing LPL recapitulated these findings. Our data suggest that LPL is a novel feature of liver-related preautonomic neurons in the PVN. Moreover, LPL loss is sufficient to cause changes in neuronal substrate utilization and function, which may precede changes in hepatic metabolism.

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