Добірка наукової літератури з теми "Adaptations métaboliques"
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Статті в журналах з теми "Adaptations métaboliques":
Jacovetti, C., and R. Regazzi. "Adaptations métaboliques au cours de la grossesse." Médecine des Maladies Métaboliques 6, no. 4 (September 2012): 279–87. http://dx.doi.org/10.1016/s1957-2557(12)70415-7.
Brun, J. F., E. Raynaud, O. Bouix, C. Fédou, and A. Pérez-Martin. "Adaptations métaboliques et hormonales et activité sportive." Science & Sports 12, no. 1 (January 1997): 3. http://dx.doi.org/10.1016/s0765-1597(97)80062-7.
Tissier, Mathilde Louise, and Caroline Habold. "Adaptations métaboliques et digestives des espèces hibernantes." Cahiers de Nutrition et de Diététique 52, no. 3 (June 2017): 150–59. http://dx.doi.org/10.1016/j.cnd.2017.03.003.
Andreelli, Fabrizio. "Brèves: Quelles adaptations métaboliques face à un excès de nutrition ?" Médecine des Maladies Métaboliques 13, no. 7 (November 2019): 622. http://dx.doi.org/10.1016/s1957-2557(19)30187-7.
ÉTIENNE, M., and M. C. PÈRE. "Adaptations physiologiques et métaboliques au cours de la gestation chez la truie." INRAE Productions Animales 11, no. 3 (June 3, 1998): 250–53. http://dx.doi.org/10.20870/productions-animales.1998.11.3.3951.
Theurel, Jean, Ludovic Rochette, Gil Borelli, Serge Dessel, and Jean-Bernard Fabre. "Adaptations neuromusculaires et métaboliques aigues lors d’un exercice dewhole bodyvibrationde faible fréquence." Movement & Sport Sciences – Science & Motricité, no. 80 (2013): 51–59. http://dx.doi.org/10.1051/sm/2013046.
FAULCONNIER, Y., M. BONNET, F. BOCQUIER, C. LEROUX, J. F. HOCQUETTE, P. MARTIN, and Y. CHILLIARD. "Régulation du métabolisme lipidique des tissus adipeux et musculaires chez le ruminant. Effets du niveau alimentaire et de la photopériode." INRAE Productions Animales 12, no. 4 (September 1, 1999): 287–300. http://dx.doi.org/10.20870/productions-animales.1999.12.4.3889.
Theurel, Jean, Ludovic Rochette, Gil Borelli, Serge Dessel, and Jean-Bernard Fabre. "Adaptations neuromusculaires et métaboliques aigues lors d'un exercice de whole body vibration de faible fréquence." Movement & Sport Sciences 80, no. 2 (2013): 51. http://dx.doi.org/10.3917/sm.080.0051.
Boussaidi, L., C. Petibois, A. M. Melin, and G. Cazorla. "Adaptations métaboliques à l'entraînement en début de saison de natation. Différences en fonction du sexe." Science & Sports 18, no. 1 (February 2003): 16–19. http://dx.doi.org/10.1016/s0765-1597(02)00054-0.
FAURE, J., L. LEFAUCHEUR, and B. LEBRET. "Adaptation du métabolisme énergétique du porc au cours de la croissance et production de viande porcine de qualité." INRA Productions Animales 28, no. 5 (January 14, 2020): 369–82. http://dx.doi.org/10.20870/productions-animales.2015.28.5.3040.
Дисертації з теми "Adaptations métaboliques":
Delamarche, Paul. "L'enfant et l'exercice prolongé : adaptations métaboliques et hormonales." Lyon 1, 1992. http://www.theses.fr/1992LYO1H185.
Touron, Julianne. "Adaptations métaboliques en réponse à l'exercice excentrique dynamique : application au réentrainement." Thesis, Université Clermont Auvergne (2017-2020), 2020. https://tel.archives-ouvertes.fr/tel-03177393.
Chronic pathologies are the world leading cause of death. In addition to reducing functional capacities and degrading patients' life quality, they constitute a major public health expenditure. Part of the management involves appropriate physical activity and exercise training. This aims to improve subjects' capacities, in particular endurance and muscle strength, in order to increase their autonomy and reduce the risk of morbidity and mortality. Classically, endurance cycling or treadmill running exercises are performed at a sub-maximal metabolic intensity (~60%) and in a classic concentric muscle contraction mode. These training conditions, and the associated adaptations, are however limited by the patients' ability to achieve or maintain such stresses over time. It is therefore necessary to develop alternative strategies that take into account cardiac, respiratory and/or muscular limitations linked to the pathology while allowing optimal adaptive responses. One approach is that of dynamic eccentric training through resistance pedaling or downhill running exercises. Compared to concentric mode, eccentric has the ability to generate significant mechanical loads for less cardio-respiratory stress. For several years, the feasibility of this type of training has been observed, including in patients with chronic diseases. Its effectiveness in increasing muscle mass and strength has also been widely demonstrated. Recent work also shows its interest in overweight and obesity management through its effects on body composition and fat reduction. However, aerobic adaptations following eccentric training remain incomplete with regard to initial expectations of improved oxygen uptake and mitochondrial function, for which exercise metabolic intensity appears to be the determining factor. Thus, mixed approaches can be considered in order to develop the best combination that will optimize the overall physical training outcomes by enhancing both muscle strength and endurance
Weitten, Mathieu. "Adaptations métaboliques et influence du régime alimentaire chez un hibernant food-storing." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ080/document.
This thesis presents the specific adaptations of food-storing hibernators that feed during hibernation, and the impact of diet quality on their annual cycle. In contrast to the fat-Storing species which fast during hibernation, the food-storing presents metabolic responses to an alternation of short fasting phases and hyperphagia. These responses involve one hand use of fat reserves during hibernation contributing to ketogenesis, which would be induced by adiponectin. On the other hand, maintaining a functional digestive system leading to the secretion of incretins, permits optimal nutrient absorption in the short inter-torpor euthermia. Increased glucose uptake in particular would restore body reserves to spare. Moreover, a lean protein diet enriched in fat and induces increased in body mass in pre-hibernation period causing reduced use of torpor thus an increased loss of mass during hibernation, and decreased reproductive success
Wargnies, Marion. "Adaptations métaboliques de Trypanosoma brucei en réponse à des variations des conditions intra- et extracellulaires." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0200/document.
Trypanosoma brucei is a protozoan parasite responsible for human African trypanosomiasis. His complex life cycle alternates between mammalian hosts and the insect vector, the tsetsefly. During this cycle, the parasite encounters dissimilar environments and adapts to the sechanging conditions by regulating his metabolism. We have studied intermediate and energetic metabolism of the procyclic form living in the midgut of the insect vector. In this glucose-depleted environment, gluconeogenesis is crucial for growth and viability of the parasites. Indeed, it allows the synthesis of hexoses phosphates and in particular glucose 6-phosphate which feeds several essential biosynthetic pathways. Our work has confirmed the existence of a gluconeogenic flux fed by proline and glycerol. We have shown that glycerol is an efficiently metabolized carbon source and is preferentially used by the procyclic form rather than proline or even glucose. This situation never described before highlights glycerol repression on glucose metabolism. We have also showed that the enzyme fructose 1,6-biphosphatase (FBPase), specific of the gluconeogenesis, is not essential for the viability ofthe parasite in glucose-depleted conditions, suggesting that there is an alternative to this enzyme. However, FBPase plays an important role for virulence of T. brucei in the insect. Moreover, we have showed another adaptation strategy developed by T. brucei which is basedo n genomic rearrangements leading to the synthesis of chimeric genes
Dansou, Houndjoui Pierre. "Adaptations cardiorespiratoires, métaboliques et hormonales au cours d'un match de tennis : du laboratoire au terrain." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10091.
Martin, Bernabe Alfonso. "Une approche protéomique pour comprendre les adaptations métaboliques du cancer du poumon non à petites cellules." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS027.
Lung cancers are broadly classified into two main groups: small cell lung cancer and non-small cell lung cancer (NSCLC), which accounts for approximately 83% of all lung cancer cases with an overall 5-year survival rate of 21%. Conventional therapies in NSCLC including radiotherapy and platinum-based chemotherapy lack specificity and often cause severe side effects as they affect healthy cells. To address this problem, targeted therapies have been successfully used due to their specificity for cancer cells. Targeted therapies against epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements have been shown to be effective in NSCLC. However, therapeutic response may be limited due to drug resistance. This is the case of patients whose tumors harbor activating KRAS mutation that leads to constitutive activity of RAS signaling independent of upstream signals. For this reason, a better comprehension of tumor progression and resistance is needed to improve cancer treatments. To date, approaches targeting oncogenic KRAS have been unsuccessful. Given the importance of metabolic reprogramming in multiple cancers including lung cancer and the regulatory role of KRAS signaling. We explored the metabolic reprogramming of KRAS-driven NSCLC cells to find vulnerabilities in the altered metabolism that can be exploited as therapeutic targets.For this, we characterized the proteome of NSCLC cell lines (A549 and NCI-H460) harboring activating mutations of the oncogene KRAS with particular focus on metabolic enzymes. We found not only up-regulation expression of glycolytic enzymes, which is frequently found in cancer as part of the “Warburg effect”, but also a remarkable up-regulation of the pentose phosphate pathway (PPP) in both oxidative and non-oxidative branches. Based on this study, we evaluated the feasibility of use PPP enzyme (glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) and transketolase (TKT)) as targets for improve or develop of new therapies.Recently, protein lysine acetylation (KDAC) has emerged as a metabolism-coordinating mechanism and mounting evidence has shown that acetylation regulation of metabolic enzymes plays a major role in cancer. Consequently, lysine deacetylases inhibitors (KDACIs) have drawn attention not only as promising strategies for therapeutic intervention but also as tool for studying the role of lysine acetylation in NSCLC metabolic reprogramming. Furthermore, metabolic reprogramming also depends strongly on the tumor microenvironment such as oxygen level. Therefore, we also analyzed the inhibition of KDAC under normoxic and hypoxic conditions in order to better understand the adaptive strategies under such perturbations. Our results showed that KDACIs induce low cell proliferation, differentiation, cell cycle arrest and apoptosis accompanied by a change in the tumor metabolic phenotype enhanced under hypoxia. Together, these results allow us to better understand how KDACIs control metabolic pathways under hypoxia in NSCLC
Refeyton, Alice. "La survie et les adaptations métaboliques des cellules primitives mésenchymateuses et hématopoïétiques en anoxie et anoxie/aglycémie." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0028.
Mesenchymal stromal cells (MStroC) comprise multipotent stem cells (SC) capable of regenerating tissues damaged by ischemic insults. However, high mortality of MStroC after transplantation is highlighted during their engraftment. Therefore, exploring strategies to improve the viability of cell grafts constitutes the challenge of cell therapy. To this end, we performed functional and metabolic analyzes on two different types of populations containing somatic SC: MStroC and a population of hematopoietic niche partner cells, CD34+.MStroC or CD34+ cells were cultured under conditions of anoxia (absence of O2) and ischemic type (anoxia/aglycemia, absence of O2 and glucose, AA) or at 3% O2 corresponding to the physiological optimal concentration, then analyzed.Functional assays reveal that MStroC and CD34+ cells exhibit complete proliferation and differentiation properties in anoxia. Functional analyzes of single cells and gene expression revealed that MStroC and CD34+ are not only maintained in an AA state, but are those in which SC, having the highest proliferation and differentiation capacity, are the most enriched. Multiparametric metabolic analysis shows that survival in anoxia is mainly supported by glycolysis and lipid metabolism. On the other hand, the energy homeostasis of MStroC in the AA condition is partially ensured by anaerobic mitochondrial activity particularly involving mitochondrial complexes I, III and ubiquinone. Furthermore, a significant accumulation of succinate in this condition for both types of SC was demonstrated. This is due in part to an inversion of succinate dehydrogenase, which in turn is driven by fumarate spillover from purine nucleotide degradation and malate-aspartate shuttle activity. However, major pathways contributing to succinate accumulation include glycogen-induced glucose/pyruvate stimulation, as well as ketone body, amino acid, and propanoate metabolism which provide succinyl-CoA converted to succinate. Furthermore, MStroC ischemia survival is linked to sulfide metabolism and H2S consumption, as well as improved survival in the presence of H2S donors. SQR-mediated H2S oxidation results in reverse electron transport at mitochondrial complex I, using glutathione as an electron acceptor. The analysis of the use of energy substrates showed that CD34+ cells in anoxia seem to mainly use simple sugars in order to fuel the glycolytic pathway and a consequent reduction in mitochondrial metabolism compared to the 3% O2 condition. In contrast, in AA, Krebs cycle intermediates are used intensively to provide the coenzyme NAD/NADH.Our results reveal a great metabolic flexibility of MStroC and CD34+ populations based on the enrichment of somatic SC detected in anoxia or in the condition mimicking ischemia. Thus, unlike differentiated cells, somatic SC (mesenchymal and hematopoietic) have the capacity to survive in conditions of anoxia and aglycemia using the evolutionary conservative energy pathways existing in early eukaryotes living in anoxic zones enriched in sulfide . Exploiting this ex vivo conditioning under conditions mimicking ischemia could constitute a strategy to improve the survival of MStroC implanted in hypoxic/ischemic tissues
Couturier, Karine. "Adaptations métaboliques et hormonales chez le rat anti-obèse Lou/C : influences du régime alimentaire et de l'activité physique." Lyon 1, 2003. http://www.theses.fr/2003LYO10104.
Ennequin, Gaël. "Rôle de la neuréguline 1 dans les adaptations du métabolisme énergétique en condition de pathologies métaboliques : effets de l'activité physique." Thesis, Clermont-Ferrand 2, 2015. http://www.theses.fr/2015CLF20028.
Neuregulin 1 (NRG1) is a cytokine that belongs to the epidermal growth factors family. NRG1can be released during exercise and can be define as a myokine. Initially studied for its rolein growth and maturation, NRG1 can also regulate glucose homeostasis in vitro. Thus, theaim of this work was to investigate the effect of training and metabolic disorders on NRG1pathway and its role in energy metabolism. Results showed that NRG1 pathway was notaltered in skeletal muscle of obese rats. Conversely, endurance training combined with awell-balanced diet improved NRG1 pathway activation in skeletal muscle of obese. Indeed, 8weeks of training and diet increased the cleavage of NRG1 and the activation of its receptorErbB4 through the activation of the metalloprotease ADAM17. Moreover, acute and chronictreatment improved glucose tolerance in diabetic mice (db/db). Acute treatment loweredglycemia by activating ErbB3, Akt and FOXO1 in the livre. Thus, NRG1 might play a key role inthe regulation of glucose homeostasis in people who suffers from metabolic disorders.Training might a good tool to activate this pathway in skeletal muscle
Teulier, Loïc. "Adaptations métaboliques du caneton de Barbarie (Cairina moschata) et du Manchot Royal (Aptenodytes patagonicus) en réponse à un stress chronique froid." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00799347.
Книги з теми "Adaptations métaboliques":
Smeltzer, Suzanne C. O'Connell. Brunner-Suddarth soins infirmiers--médecine et chirurgie. 3rd ed. Saint-Laurent, Québec: Éditions du Renouveau pédagogique, 1994.