Дисертації з теми "Acute Leukaemia"
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Bomken, Simon Nicholas. "Investigating leukaemic propagation in childhood acute lymphoblastic leukaemia." Thesis, University of Newcastle Upon Tyne, 2013. http://hdl.handle.net/10443/1865.
Повний текст джерелаBradbury, Dawn Ann. "Factors regulating the autocrine growth of leukaemic cells in acute myeloblastic leukaemia." Thesis, Nottingham Trent University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332817.
Повний текст джерелаKnapper, Steven. "FLT3 inhibitors in acute myeloid leukaemia." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432548.
Повний текст джерелаSmith, Matthew Liam Walker. "Mutation profiling in acute myeloid leukaemia." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416112.
Повний текст джерелаQuinn, M. F. "Homeobox gene expression in acute leukaemia." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398094.
Повний текст джерелаMannari, Deepak. "The genomics of acute myeloid leukaemia : an investigation into the molecular pathogenesis of acute myeloid leukaemia with t(8;21)." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8822.
Повний текст джерелаSwanepoel, Yolande. "A retrospective study of acute lymphoblastic leukaemia in Paediatric patients at Dr George Mukhari Hospital (2003-2007)." Thesis, University of Limpopo (Medunsa Campus), 2008. http://hdl.handle.net/10386/262.
Повний текст джерелаIntroduction: ALL (Acute Lymphoblastic Leukaemia) is the most common leukaemia in childhood. The two most important features predictive of outcome are age and presenting WBC at diagnosis. NCI risk criteria are applied to all children with precursor B-ALL, dividing them into NCI “high risk” (age < 1 year and ≥ 10 yrs, WBC > 50 x 10 9/ ) and NCI “standard risk” (age ≥ 1 year and < 10 yrs, WBC < 50 x 10 9/ ). Gender, immunophenotyping and genetic studies are other features that have been shown to be associated with outcome. Objectives: To determine the correlation between survival outcome of paediatric patients with ALL and different variables, e.g. biological, haematological, immunophenotypic and cytogenetic features at diagnosis, and to determine the duration of survival of a patient since the diagnosis of ALL, at Dr George Mukhari Hospital. Methods: This study was conducted over the period 2003-2007. Children diagnosed with ALL with ages ranging from 1-12 years, were identified. The hospital and laboratory records were analysed retrospectively. Early prognostic features were identified from patient data. Results: Descriptive statistical measures were used to summarize data. Twenty nine paediatric patients with ALL were identified of which 12 were female and 17 were male. The mean age of patients at diagnosis was 7,2 years. The presenting leucocyte count ranged from 2,5 to 325 x 10 9/ . Cytogenetic studies of three patients were available, all of which were unfavourable prognostic factors. Immunophenotyping revealed ten patients with T-cell ALL, 17 patients with B-cell ALL and two patients whose immunophenotype was unknown as recorded results were not available. Twenty one patients’ survival data were known. The longest duration of survival of a patient was 3,7 years. There were seven patients known to be alive at the end of the study period. Conclusion: The cases reported herein and those described in the literature demonstrate the importance of a careful and multidisciplinary approach in the diagnosis and evaluation of paediatric ALL.
Taussig, David. "Characterisation of acute myeloid leukaemia stem cells." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424766.
Повний текст джерелаCartwright, Cher Suzanne. "Thiopurine Metabolism in Childhood Acute Lymphoblastic Leukaemia." Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500442.
Повний текст джерелаOlwill, Shane. "Annexin II expression in acute myeloid leukaemia." Thesis, University of Ulster, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274092.
Повний текст джерелаArmenteros-Monterroso, Elena. "Investigating reptin function in acute myeloid leukaemia." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10038392/.
Повний текст джерелаStringaris, Katherine. "Natural killer cells and acute myeloid leukaemia." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18014.
Повний текст джерелаDokal, Arran D. "Investigating the heterogeneity of leukaemia kinase networks and the impact of the microenvironment on leukaemic cell signalling." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/36218.
Повний текст джерелаCarapeti, Melina. "Identification of acquired genetic changes in acute leukaemia." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287882.
Повний текст джерелаMorgan, Rhys. "Role of γ-catenin in acute myeloid leukaemia". Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55145/.
Повний текст джерелаElmantaser, Musab Elmabrouk M. "Bone health in children with acute lymphoblastic leukaemia." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4447/.
Повний текст джерелаWilson, Kerrie Lauren. "Malignant stem cells in childhood acute lymphoblastic leukaemia." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525030.
Повний текст джерелаBrown, Nicola Jane Marie. "Inactivation of P21(WAF1/CIP1) in acute leukaemia." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446232.
Повний текст джерелаSorour, Amani Fouad Abdel Halim. "Chromosome 6q16-21 deletions in acute lymphoblastic leukaemia." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399158.
Повний текст джерелаPyzer, Athalia Rachel. "Myeloid-derived suppressor cells in acute myeloid leukaemia." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/36704.
Повний текст джерелаGreen, C. L. "Studies on CEBPA mutations in acute myeloid leukaemia." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1379542/.
Повний текст джерелаPutwain, Sarah Lucy. "The role of Sox4 in acute myeloid leukaemia." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648624.
Повний текст джерелаMangolini, M. "Oncogenic signalling in t(12;21) Acute Lymphoblastic Leukaemia." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1415780/.
Повний текст джерелаJackson, Rosanna Katherine. "Personalisation of dexamethasone in childhood acute lymphoblastic leukaemia." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3940.
Повний текст джерелаAustin, Stephen J. "The prognostic significance of the mixed lineage leukaemia partial tandem duplication in acute myeloid leukaemia." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54154/.
Повний текст джерелаHussey, Damian J. "An investigation of the (4;11)(q21;p15) translocation in acute lymphocytic leukaemia /." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phh9725.pdf.
Повний текст джерелаCopies of author's previously published articles inserted. Errata pasted onto verso of back end-paper. Bibliography: leaves 163-189.
Chim, Chor-sang James. "Study of gene promoter methylation in acute promyelocytic leukaemia." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25256725.
Повний текст джерелаEvans, Jane P. M. "Tyrosine protein kinases and their substrates in acute and chronic leukaemias and their leukaemia cell lines." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235871.
Повний текст джерелаGrandage, V. L. "Investigation of aberrant signal transduction in acute myeloid leukaemia." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445527/.
Повний текст джерелаIvey, Adam Stuart. "Molecular characterisation and tracking disease in acute myeloid leukaemia." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/molecular-characterisation-and-tracking-disease-in-acute-myeloid-leukaemia(a3aac920-4bbe-4360-afbd-2bd1dbe5e738).html.
Повний текст джерелаRehe, Klaus. "Diversity of cancer stem cells in acute lymphoblastic leukaemia." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1777.
Повний текст джерелаLim, Seah-Hooi. "Immunotherapy and recombinant interleukin-2 in acute myeloid leukaemia." Thesis, University of Aberdeen, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484307.
Повний текст джерелаAldhafiri, Fahad Khalid. "Weight status during and after childhood acute lymphoblastic leukaemia." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4500/.
Повний текст джерелаChim, Chor-sang James, and 詹楚生. "Study of gene promoter methylation in acute promyelocytic leukaemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B25256725.
Повний текст джерела卓大治 and Tai-chi Cheuk. "Childhood acute lymphoblastic leukaemia with TEL-AML1 gene fusion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969690.
Повний текст джерелаKozlowski, Ryszard E. "Aspects of blast cell proliferation in acute myeloblastic leukaemia." Thesis, Nottingham Trent University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293853.
Повний текст джерелаSulong, Sarina. "Determination of allelic imbalance in childhood acute lymphoblastic leukaemia." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445581.
Повний текст джерелаLe, Dieu Helen Rifca. "Characterisation of T cell defects in acute myeloid leukaemia." Thesis, Queen Mary, University of London, 2009. http://qmro.qmul.ac.uk/xmlui/handle/123456789/561.
Повний текст джерелаSundaresh, A. "Aberrant transcriptional pathways in t(12;21) Acute Lymphoblastic Leukaemia." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1522624/.
Повний текст джерелаEl-Sharkawi, D. "Studies to investigate epigenetic factors in acute myeloid leukaemia." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1528735/.
Повний текст джерелаShah, Niraj Mayank. "The role of NRF2 in acute myeloid leukaemia (AML)." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3022789/.
Повний текст джерелаOram, Sarah Helen. "Cis-regulation of LM02 in T-acute lymphoblastic leukaemia." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609663.
Повний текст джерелаMansour, M. R. "Role of the Notch signalling pathway in acute leukaemia." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1420122/.
Повний текст джерелаNaiel, Abdulbasit. "Study of acute myeloid leukaemia with known chromosomal translocations." Thesis, Brunel University, 2014. http://bura.brunel.ac.uk/handle/2438/9303.
Повний текст джерелаEde, Benjamin Christopher. "Improving therapies for childhood T cell acute lymphoblastic leukaemia." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.752757.
Повний текст джерелаRIBEIRO, Ana Rita Matias Rosa de Almeida. "Insights into Acute Myeloid Leukaemia metabolism using NMR Spectroscopy." Master's thesis, Instituto de Higiene e Medicina Tropical, 2017. http://hdl.handle.net/10362/22443.
Повний текст джерелаAcute Myeloid Leukemia (AML) is the second most diagnosed type of leukemia and the most common in adults. It is a haematological disorder characterized by the bone marrow and peripheral blood infiltration of clonal populations of abnormally differentiated and highly proliferative blasts. It is a very heterogenous disease, originating from a wide variety of haematopoietic lineages with a diverse genetic landscape.(2,3) One of the less typical presentations of AML involves lactic acidosis (the accumulation of lactate in the blood) which has been correlated with poor survival prognosis. (4) This condition is correlated with high rates of aerobic glycolysis, the “Warburg effect”, resulting in the production of lactate that is excreted to the microenvironment. Several studies have found that some cancer cells have can take up lactate and utilize it as a source for oxidative metabolism.(5,6) We studied the glucose and lactate metabolism of three different AML lineages (HL60, THP1 and HEL) through NMR spectroscopy. We also investigated the influence of VEGF (another key player in tumour microenvironment, known to be involved in tumour-related angiogenesis in AML) in these cell lines.(7) Our results showed that the promyelocytic and monocytic lines can rely on lactate to sustain their energy and biomass demands, utilizing it as substrate for the TCA cycle and oxidative phosphorylation. On the monocytic line we confirmed that glucose is mainly metabolized through glycolysis and pentose phosphate pathway. The erythroleukemic line was unable to sustain its metabolism on lactate consumption, being dependent on glucose to sustain the cells’ metabolism. VEGF seem to have a positive effect on the HL60 and THP1 lines, increasing glycolytic rates and promoting nucleotide production, which suggest that it may have a role in supporting the alternative metabolism exhibited by these cells. So, the three lineages of AML display very different metabolic plasticity, with some having adapted to take advantage of their environment, while others seeming unable to adjust. We also investigated how exposure to different microenvironments influences AML cell metabolism. The normal environment of AML is the bone marrow (BM), but the cells can spread and accumulate in other organs of the body, where they are required to adapt to a completely different environment. In some cases, AML can involve infiltration of the Central Nervous System, usually in the form of leptomeningeal disease.(1) We inoculated HEL cells into the brain and BM of mice and, through multivariate analysis of NMR data, were able to distinguish between the metabolic profiles of the cells exposed to the two environments. Our results showed that the HEL cell line is much better suited to survive in the BM microenvironment than in the brain microenvironment. In both microenvironments, there were gradual metabolic modifications as the result of increased exposure, indicating that cell metabolism is not static and is influenced by the characteristics of the surrounding microenvironment. In conclusion, we showed that understanding leukaemia metabolism and its interaction with the microenvironment is indispensable for disease characterization and can provide valuable insights into the biologic mechanisms that govern AML progression and survival.
Yu, N. "Identifying and targeting dormant cells in acute myeloid leukaemia." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33679/.
Повний текст джерелаRobinson, Hazel M. "Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/161483/.
Повний текст джерелаKrishnamurthy, Pramila. "Cellular and vaccination-based immunotherapy of acute myeloid leukaemia." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/cellular-and-vaccinationbased-immunotherapy-of-acute-myeloid-leukaemia(ea5188b6-c807-4a99-8473-e99f55f19559).html.
Повний текст джерелаCheuk, Tai-chi. "Childhood acute lymphoblastic leukaemia with TEL-AML1 gene fusion." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22264619.
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