Дисертації з теми "Active SWR"
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Coquillas, Benjamin. "Nouvelles topologies d’amplificateurs de puissance SiGe en bande Ku, optimisées en puissance, rendement et robustes au TOS actif." Thesis, Bordeaux, 2022. http://www.theses.fr/2022BORD0173.
Повний текст джерелаThe improvement of the RADAR systems of the current aircraft is confronted with the two major challenges of the reduction of the areas occupied and the control of the cost. These challenges are added to the specific material constraints of self-guided missiles concerning power handling at high temperature and robustness to external load variations caused by the misalignment of surrounding radiating elements (related to the active SWR phenomenon). A major challenge is based on the response of the power amplifier, identified as an elementary building block, to these current challenges. The Silicon Germanium (SiGe) technology is highlighted by many academic works on new generations of telecommunications (5G, 6G). Several recent works on power amplifiers published between 2016 and 2020 bring results close to the desired characteristics on X-band and low Ku-band. This dual industrial and academic context justifies an original study on the characteristics and limits of the SiGe technology at the top of the Ku band with regard to the output power, efficiency, robustness to active SWR and the power handling to temperature variations. During this work, with the support of a documented bibliographical study and acurrate specifications, five power patterns and three types of coupler are designed, simulated, sent to manufacturing and measured. The balanced architecture topology, highlighted in several self contained studies, is a central pillar of this study. The design choices and the performances obtained are detailed. These are compared to the state of the art. They demonstrate significant advances valued in three major conferences in the scientific field and provide original answers to the contemporary challenges of designing power amplifiers for a RADAR application within self-guided missiles
Pinier, Jeremy. "Low-dimensional techniques for active control of high-speed jet aeroacoustics." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2007. http://wwwlib.umi.com/cr/syr/main.
Повний текст джерелаMastandrea, Vicenzo. "Analyse de synchronisation dans les objets actifs basée sur les types comportementaux." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4113/document.
Повний текст джерелаThe active object concept is a powerful computational model for defining distributed and concurrent systems. This model has recently gained prominence, largely thanks to its simplicity and its abstraction level. In this work we study an active object model with no explicit future type and wait-by-necessity synchronisations, a lightweight technique that synchronises invocations when the corresponding values are strictly needed. Although high concurrency combined with a high level of transparency leads to good performances, they also make the system more prone to problems such as deadlocks. This is the reason that led us to study deadlock analysis in this active objects model.The development of our deadlock analysis is divided in two main works. In the first work we focus on the implicit synchronisation on the availability of some value. This way we are able to analyse the data-flow synchronisation inherent to languages that feature wait-by-necessity. In the second work we present a static analysis technique based on effects and behavioural types for deriving synchronisation patterns of stateful active objects and verifying the absence of deadlocks in this context. Our effect system traces the access to object fields, thus allowing us to compute behavioural types that express synchronisation patterns in a precise way. As a consequence we can automatically verify the absence of deadlocks in active object based programs with wait-by-necessity synchronisations and stateful active objects
Kahn, Seth Louis. "Grassroots democracy in process: Ethnographic writing as democratic action." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2002. http://wwwlib.umi.com/cr/syr/main.
Повний текст джерелаBreschet, Gilbert. "Recherches sur les hydropisies actives en général et sur l'hydropisie active du tissu cellulaire en particulier présentées à la Faculté de médecine de Paris le 31 août 1812 /." Paris : BIUM, 2003. http://www.bium.univ-paris5.fr/histmed/medica/cote?TPAR1812x173.
Повний текст джерелаOnken, Christopher Alan. "Measurement of black hole masses in active Galactic Nuclei." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1125427208.
Повний текст джерелаDi, Pasqua Anthony J. "Carboplatin Exploring mechanism of action and improved drug delivery 1. Role of carbonate in the mechanism of action of carboplatin 2. Cytotoxicity of mesoporous silica nanomaterials /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2008. http://wwwlib.umi.com/cr/syr/main.
Повний текст джерелаQueen, Mary Teresa. "Technologies of representation fields of rhetorical action in transnational feminist encounters /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2005. http://wwwlib.umi.com/cr/syr/main.
Повний текст джерелаMaës, Clément. "Plasmonique active pour l’infrarouge sur semi-conducteur fortement dopé." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTS033.
Повний текст джерелаThe context of my thesis deals with infrared (IR) multispectral imaging and in particular with plasmonics, a field of electromagnetic optics whose the aim is to study and exploit surface waves existing at the interface between a metal and a dielectric. We seek to miniaturize optical functions thanks to nanotechnologies and more precisely to perform IR spectral filtering at the detection pixel level by integrating a nano-resonator. Usually we use dielectrics and metals, but the integration is complex. I am exploring the potential offered by heavily doped semiconductors to replace metals, which could allow better integration into technological processes for fabricate a photodetector or emitter. I use III-V semiconductors, compatible with the epitaxial growth of type 2 superlattice (T2SL) of long wave infrared photodetectors (LWIR). Furthermore, working with a heavily doped semiconductor offers the possibility of modifying the resonance frequency by adjusting the density of free carriers by the action of a potential difference.I study architectures of "GMR" components (Guided-Mode Resonance), usually formed by a waveguide in dielectric, where occurs the resonance, and a grating in dielectric or metal allowing the coupling between the incident or transmitted wave and the guided mode thanks to the ±1 orders diffracted by the grating in the thin layer. The current trend is to integrate these components directly at the level of the detection pixel but at the cost of numerous fabrication steps. I am studying the possibility of using exclusively semiconductors to simplify the fabrication process and allow monolithic integration of the filter into the detector. The waveguide consists of an intrinsic semiconductor and the grating of heavily doped semiconductor. The spectral range of interest is in the far infrared (8 μm - 14 μm).First, theoretical and experimental demonstrations of an all-semiconductor nano-structured spectral filter for infrared based on guided-mode resonance were carried out. I dimensioned and then fabricated a sample where the first step consists in depositing by epitaxy a layer of GaSb and a layer of highly doped InAsSb on a GaAs substrate before a photolithography step to define the mask of the etching reactive ionic etching in order to obtain the diffraction grating. An experimental work then made it possible to characterize the component (measurement under normal incidence, angular study, measurement at low temperature) with in particular the realization of an angular characterization setup.In parallel, I studied an appropriate stack of doped materials allowing, by applying an electrical voltage, to move the free electrons from doping in the grating and the guide, which then locally modifies the refractive index and therefore directly the conditions for guiding the light by phase variation. Different approaches have been presented in an attempt to adjust the resonance wavelength of the GMR spectral filter: accumulation and depletion of charges in the diffraction grating, insertion of a PN junction in the waveguide, ...Finally, a first brick for the integration of a T2SL in an optical nano-resonator to make an all-semiconductor nano-structured photodetector was studied. I proposed the theoretical design of several nano-resonators integrating a T2SL type photodetector (InAs/GaSb). I designed three architectures with distinct spectral properties, which differ in particular in the thickness of the T2SL layer
Kaddah, Rim. "Gestion active de la demande basée sur l'habitat connecté." Thesis, Paris, ENST, 2016. http://www.theses.fr/2016ENST0025/document.
Повний текст джерелаThe Internet of Things (IoT) paradigm brings an opportunity for advanced Demand Response (DR) solutions. Indeed, it enables visibility and control on the various appliances that may consume, store or generate energy within a home. In this thesis, we consider solutions having the capability to produce direct control decisions at different granularities based on variables measured at homes. Control schemes are driven by an optimization based on utility functions. These functions are defined based on a generic approach that considers load’s flexibility and the impact of control decisions on users. The proposed approach does not impose any restrictions on the type of controlled appliances nor on the granularity of control decisions. This enables joint control of heterogeneous loads. We consider three types of control architectures, namely centralized, partially distributed and fully distributed solutions. Schemes based on these architectures differ in the distribution of decision making among entities involved in the control and data that is made available to these entities. Numerical analysis shows the trade-offs of proposed solutions from a performance, scalability and complexity perspectives
Gilbert, Claude. "Etude de l'action du charbon active sur la production des gaz intestinaux." Nancy 1, 1988. http://www.theses.fr/1988NAN11011.
Повний текст джерелаSalazar, Soto Arnoldo. "Conception d'un imageur CMOS à colonne active pour un biocapteur optique SPR." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENT063/document.
Повний текст джерелаThis dissertation presents the design and implementation of a CMOS imager for use in integrated biosensors based on Surface Plasmon Resonance. First, the optimal conditions for plasmon resonance in a CMOS/Post-CMOS compatible interface are obtained by COMSOL modelling. Second, a 32x32-pixel CMOS-Active Column Sensor (CMOS-ACS) is implemented on 0.35 um CMOS technology. In a gold-water interface with prism excitation, it is found that for prisms showing refractive indexes of 1.55 and 1.46, optimal plasmon coupling is obtained for gold films with thicknesses of 50 and 45 nm respectively. Under these conditions, approximately 99.19% and 99.99% of the incident light's energy is transferred to the surface plasmon for both prism respectively, provided that the incident light, with a wavelength of 633 nm, arrives with incidence angles of 68.45° and 79.05° respectively. It is also obtained that a change of 10-4 RIU in the refractive index of the dielectric medium, produces a change of 0.01° in the plasmon resonance angle, which under a light intensity modulation scheme produces a change of 0.08% in the reflected light's energy reaching the photodetector. Concerning the CMOS imager, a n-well/p-substrate photodiode is selected as the photosensing element, due to its low junction capacitance, which results in high efficiency and high conversion gain compared to the n-diff/p-substrate photodiode. Computer simulations with Cadence and Silvaco produced a junction capacitance of 31 fF and 135 fF respectively. The imager's pixel is based on a three-transistor (3T) configuration and shows a fill factor of 61%. The readout circuitry employs an Active Column Sensor (ACS) technique to reduce the Fixed Pattern Noise (FPN) associated with traditional Active Pixel Sensors (APS). Additionally, Non-Correlated Double Sampling (NCDS) and Delta Double Sampling (DDS) are used as noise reduction techniques. An experimental optical setup is used to characterize the performance of the imager, obtaining a conversion gain of 7.3 uV/e-, a photodiode junction capacitance of 21.9 fF, a read noise of 324.5 uV, equivalent to ~45 e- and a dynamic range of 50.5 dB. The benefits of ACS and NCDS-DDS are observed in the low pixel and column FPN of 0.09% and 0.06% respectively. The work presented in this thesis is a first step towards the goal of developing a fully integrated SPR-biosensing platform incorporating light source, SPR interface, microfluidic channel, optical elements and CMOS imager
Reig, Benjamin. "Vers l'intégration monolithique d'une micro-optique polymère active sur VCSELs." Toulouse 3, 2011. http://thesesups.ups-tlse.fr/1501/.
Повний текст джерелаThis thesis deals with the study and the development of novel polymer MOEMS (Micro Optical Electrical Mechanical Systems) for Vertical-Cavity Surface-Emitting Lasers (VCSELs) passive and active beam shaping. To improve the photonic integration of these compact laser sources in optical communication and detection systems (sensors, biomedical analysis), we have designed and fabricated a polymer-based microsystem suitable for a monolithic integration on VCSELs. It includes a refractive microlens deposited onto a suspended membrane that is moved vertically to modify dynamically the microlens-source distance. MOEMS design has been optimized by means of numerical modeling of Gaussian laser beam propagation as well as of membrane thermo-mechanical actuation. Technological steps for collective fabrication on VCSELs arrays have been developed. In particular, several methods for microlens optimal alignment relatively to the laser source have been investigated. SU-8 reliability resist has been also studied. Finally, fabricated MOEMS have been characterized. A vertical displacement of 8µm has been achieved under 3V applied, in good agreement with modeling results. This corresponds to a shift of lens focal plane of 20µm, thus demonstrating the interest of our approach
Raad, Hussein. "Modélisation d'un système hypermédia adaptatif basé sur la règle active." Pau, 2002. http://www.theses.fr/2002PAUU1015.
Повний текст джерелаSalama, Asem. "Recherche sur les traces et dépôts de tsunami le long de la côte méditerranéenne de l'Egypte : contexte sismotectonique et modélisation." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAH012/document.
Повний текст джерелаSeismotectonic, paleotsunami deposits and tsunami scenarios are investigated along the north coast of Egypt in the framework of the tsunami ASTARTE European and the French-Egyptian IMHOTEP projects. The geology, geomorphology, seismicity, focal mechanisms, calculated stress inversion, and GPS data were used to identify the present day stress regime of the main active zones and the tsunamigenic zones. Trenches and cores were dug in Kefr Saber and EL Alamein sites. X-ray scanning, magnetic susceptibility, grain size analysis, sampling, macrofossil detections, XRD analysis, total organic and inorganic matter measurements and carbon dating are carried out to identify the paleotsunami signatures. The high-energy white sandy layer rich in reworked fossils at Kefr Saber are correlated with 21 July 365, while the four characteristic high-energy sedimentary layers at the El Alamein site are correlated with the historical tsunami events of 1600 BC, 21 July 365, 8 August 1303, and 24 June 1870
Chamoun, Maroun. "Intégration de l'Internet 3G au sein d'une plate-forme active." Phd thesis, Télécom ParisTech, 2006. http://pastel.archives-ouvertes.fr/pastel-00001749.
Повний текст джерелаKadala, Pyabalo Aklesso. "Action des pyréthrinoïdes sur le canal sodique activé par le potentiel des neurones du système olfactif de l'abeille domestique Apis mellifera." Thesis, Avignon, 2011. http://www.theses.fr/2011AVIG0327/document.
Повний текст джерелаIn domestic honeybees, the olfactory receptor neurons localized in the antennae are primary sensory neurons responsible for the detection of odor and pheromone compounds. The olfactory information is further conveyed to the antennal lobes by the antennal nerves. The antennal lobes are the first stage of integration of the olfactory information. Forager bees are exposed to insecticides, especially pyrethroids that are used for plant protection and eradication of pests.In the honeybee olfactory pathway, we investigated the effects of pyrethroids on the voltage-gated sodium channels (which underlie action potentials). Our patch-clamp recordings in the antennal olfactory receptor neurons maintained in cell culture reveal that the effects of type I and type II pyrethroids (e.g. tetramethrin and deltamethrin) are increased by an augmentation of neuronal electrical activity. The amplification of the effects of pyrethroids occurs as a result of the unmasking of silent sodium channels that we have also shown evidence for, with sea anemone toxin ATX-II. The maximal sodium channels modification takes place within few hundreds of milliseconds. In the central antennal lobe neurons, that amplification is rather limited or absent with pyrethroids but the plant alkaloid veratridine is able to induce such an amplification. Furthermore, in the latter cell type, pyrethroids cause an acceleration of the sodium channels slow inactivation. Such an effect has been previously reported for some local anesthetics. The differential actions of pyrethroids that we have observed in the peripheral and central neurons may be responsible for the impairment of learning performance, perception and disorientation exhibited by pyrethroid-exposed honeybees
Pan, Jinmei. "Application of Passive and Active Microwave Remote Sensing for Snow WaterEquivalent Estimation." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu149737615724025.
Повний текст джерелаReig, Benjamin. "Vers l'intégration monolithique d'une micro-optique active en polymère sur VCELs." Phd thesis, Université Paul Sabatier - Toulouse III, 2011. http://tel.archives-ouvertes.fr/tel-00709574.
Повний текст джерелаROUGEAUX, SEBASTIEN. "Interaction visuelle en temps-reel par stereovision active sur scene dynamique." Evry-Val d'Essonne, 1999. http://www.theses.fr/1999EVRY0002.
Повний текст джерелаEspiau, François-Xavier. "Métrologie 3D par vision active sur des objets naturels sous-marins." Nice, 2002. http://www.theses.fr/2002NICE5713.
Повний текст джерелаBenjelloun, Omar. "Active XML : une approche des services Web centrée sur les données." Paris 11, 2004. http://www.theses.fr/2004PA112087.
Повний текст джерелаThis thesis introduces Active XML (AXML, for short), a declarative framework that harnesses Web services for distributed data management, and is put to work in a peer-to-peer architecture. An AXML document is an XML document that may contain embedded calls to Web services, whose invocation enriches the document. An AXML service is a Web service that exchanges AXML documents. An AXML "peer" is a repository of AXML documents. On the one hand, it acts as a client, by invoking the service calls embedded in its documents. On the other hand, a peer acts as a server, by providing AXML services that can be declaratively specified as queries or updates over the AXML documents of its repository. The AXML approach allows for gracefully combining stored information with data defined in an intensional manner (as service calls). The fact that AXML peers can exchange a mix of materialized and intensional data (via AXML documents) leads to a very powerful distributed data management paradigm. The AXML approach leads to a number of important problems that are studied in the thesis. First, we address the issue of controlling the exchange of AXML data. We propose to use declarative schema specifications, and provide algorithms to statically enforce them. Second, we propose techniques for the "lazy evaluation" of queries on AXML documents, that detect which embedded service calls may contribute to query answers. An implementation of AXML peers compliant with W3C standards is also described in the thesis
Schneider, Béatrice. "Sur l'oxydation active des céramiques à base de carbure de silicium." Bordeaux 1, 1995. http://www.theses.fr/1995BOR10543.
Повний текст джерелаNguyen, Le Xuan Bach. "Numerical Study of Natural Convection Coupled to Gas Radiation in a Cavity Containing an Active Obstacle." Thesis, Chasseneuil-du-Poitou, Ecole nationale supérieure de mécanique et d'aérotechnique, 2020. http://www.theses.fr/2020ESMA0014.
Повний текст джерелаOur objective is to study numerically natural convection flows in an enclosure,the fluid being a gaseous mixture including absorbent components (CO2, H2O). For this purpose, we consider a cubic cavity with a source located on the floor, heating the fluid and diffusing a pollutant participating to radiation. Our calculations are performed with the CFD software Code Saturne, in which we have implemented our own data for the discrete ordinates method (new quadratures) and for modelling gas radiation (SLW method in the rank-correlated approach). In pure thermal natural convection, the results show that gas radiation slightly changes the flow structure and the temperature distribution. It reduces the convective exchanges between the fluid and the walls of the enclosure as well as the radiative exchange between the upper surface of the obstacle and the cavity boundaries. In double diffusion, in the aiding case, gas radiation tends to homogenize the thermal field and slightly accelerates the parietal boundary layers, but reduces the maximum velocity within the plume. On the other hand, it has little effect on the concentration field. In the opposing case, the radiation intensifies the thermal plume above the obstacle. It reduces the temperature in regions close to the vertical surfaces of the obstacle. The concentration field shows the same modification trends as the thermal field
Tamaro-Hans, Annick. "Incidence des événemements de vie sur les activités et la consommation : application au départ à la retraite." Paris 9, 2005. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=2005PA090038.
Повний текст джерелаLife events require adjustments. In this research, retirement is viewed as a critical life event which may involve a change in activities and in consumption patterns. Based on research from different scientific disciplines (sociology, psychology, marketing) and former studies, this research stresses the subjective experience of retirement which has four modes (“new beginning”, “withdrawal”, “rest”, “continuity”) and develops a conceptual model involving determinants (job involvement, perception of time, values, global satisfaction, resources), activities and consumption. The results indicate that subjective experience of retirement is a significant predictor of activity level and consumer behaviour. The life stage of “retirement” is suggested as a segmentation variable
Manceau, Matthieu. "Impact de la lumière sur la couche active des cellules photovoltaïques organiques." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2009. http://tel.archives-ouvertes.fr/tel-00725062.
Повний текст джерелаSalazar, A. "Conception d'un Imageur CMOS à Colonne Active pour un Biocapteur Optique SPR." Phd thesis, Université de Grenoble, 2013. http://tel.archives-ouvertes.fr/tel-00932309.
Повний текст джерелаBrasquet, Catherine. "Procédés d'adsorption sur tissus de carbone active, application au traitement des eaux." Pau, 1998. http://www.theses.fr/1998PAUU3016.
Повний текст джерелаBenjamin, Stefan Jason. "Synthesis and SAR investigation of haemozoin-inhibiting quinazolines active against Plasmodium falciparum." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22738.
Повний текст джерелаMénard, Frédéric. "Génération d'iminiums en cascade cyclisation d'énamines sur amides actives." Mémoire, Université de Sherbrooke, 2006. http://savoirs.usherbrooke.ca/handle/11143/4695.
Повний текст джерелаMénard, Frédéric. "Génération d'iminiums en cascade cyclisation d'énamines sur amides actives /." [S.l. : s.n.], 2006.
Знайти повний текст джерелаSpalenka, Jérémy. "PROTOSCREEN - Screening et identification de molécules actives sur Toxoplasma gondii et autres protozoaires d’intérêt médical et vétérinaire." Thesis, Reims, 2018. http://www.theses.fr/2018REIMM204/document.
Повний текст джерелаToxoplasma gondii, Neospora caninum and Plasmodium falciparum are mandatory intracellular protozoan parasites and are responsible for toxoplasmosis, neosporosis and malaria, respectively. The different treatments used are based on drug combination. However therapeutic failures and drug resistances have been described. Our work focused on the identification of active compounds isolated by Centrifugal Partition Chromatography (CPC) from crude barks extracts from Anogeissus leiocarpus, a West African tree known for its antimalarial activity, and ten trees from the Champagne-Ardenne region. First we studied the activity of the fractions obtained from the crude bark extract from A. leiocarpus. Trachelosperogenin E and the global extract without tannin showed a good activity by inhibiting host cell invasion by T. gondii. The latter was able to preserve mice survival toward chronic toxoplasmosis. These extracts were also active on N. caninum and P. falciparum. In a second part 30 crude barks extracts from ten trees located in the Champagne-Ardenne region were screened on T. gondii and N. caninum. Compounds responsible for the antiparasitic activity found in Alnus glutinosa were especially betulin and its derivatives. In the last part of this study we focused on the antiparasitic activity of 400 synthetic molecules from the Pathogen Box. Eight out of them were significantly efficient against T. gondii, among which three showed an important selectivity. Further experiments must be completed in the case of N. caninum
Contino-Pépin, Christiane. "Etudes sur la vectorisation et le ciblage cellulaire de principes actifs par des systèmes vésiculaires et macromoléculaires." Avignon, 1997. http://www.theses.fr/1997AVIG0004.
Повний текст джерелаLaunois, Anne-Michèle. "Nouveaux agents oxydants utilisés dans le désencrage : peroxyde activé, perborate, perborate activé, efficacité et effet sur l'environnement /." Thèse, Trois-Rivières : Université du Québec à Trois-Rivières, 1997. http://www.uqtr.ca/biblio/notice/resume/03-2180910R.htm.
Повний текст джерелаMémoire présenté à l'Université du Québec à Trois-Rivières comme exigence partielle de la maîtrise en Sciences de l'environnement. CaQTU Bibliogr. : p. [91]-95. Le résumé et la table des matières sont disponibles en format électronique sur le site Web de la bibliothèque. CaQTU
Launois, Anne-Michèle. "Nouveaux agents oxydants utilisés dans le désencrage : peroxyde activé, perborate, perborate activé, efficacité et effet sur l'environnement." Thèse, Université du Québec à Trois-Rivières, 1997. http://depot-e.uqtr.ca/5028/1/000640776.pdf.
Повний текст джерелаGupta, Neetu. "Inhibitors of intracellular trafficking active against plant and bacterial toxins." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112328.
Повний текст джерелаShiga toxins (Stx) are produced by Shigella dysenteriae and certain species of E. coli that can be transmitted to humans primarily through consumption of contaminated foods and may cause severe disease. Stx is released by the bacteria in the intestine and subsequently, could cross the downstream blood vessels to reach their main target organs such as kidney. Damage to the kidney can result in serious life-threatening complication hemolytic uremic syndrome, for which there is no proven safe treatment available other than supportive care. Stx invades renal endothelial cells in a retrograde manner from cell surface to the endoplasmic reticulum in order to gain access to its cytosolic target, 28S rRNA. By using HTS, it was previously demonstrated that the compound Retro-2 blocks retrograde trafficking of Stx at the early endosome-TGN interface, without affecting the morphology of cellular organelles and trafficking of other endogenous proteins. In this work, different regions of the lead inhibitor Retro-2 that are critical for the protective activity have been determined by systematic structure-activity relationship studies. It allowed us to identify a dihydroquinazolinone derivative, named Retro-2.1 that is the most potent inhibitor of Stx to date and also to develop bio-active photo-activatable probes with the aim of identifying the molecular target of Retro-2 derivatives. Further, crystal X-ray diffraction data revealed that the antitoxin activity resides mainly in the S-enantiomer. (S)-Retro-2.1 has displayed 500 fold more potency (50 nM) than parent molecule against Stx cytotoxicity. This study may result in a new therapeutic concept - targeting the retrograde transport route of toxin inside host cell - for the treatment of Stx-producing E. coli infections and could therefore be extended to other pathogens that also traffic via the retrograde transport. Such a new therapeutic concept that target the host cells and not the pathogen itself would represent a real breakthrough in drug discovery leading to broad spectrum drugs
Tissier, Jérôme. "Méthodologies de conception de dispositifs microondes sans pertes, filtrants, en éléments localisés, en technologie intégrée." Limoges, 2001. http://www.theses.fr/2001LIMO0052.
Повний текст джерелаThis work deal with microwave active filters design in MMIC
Berthet, Guillaume. "Revêtements diamant pour surfaces actives sur capteurs du domaine pétrolier." Electronic Thesis or Diss., Paris 6, 2017. http://www.theses.fr/2017PA066660.
Повний текст джерелаIn the field of oil and gas industry, Inconel alloys are largely used for their high strength and good corrosion resilience to H2S, CO2 and carboxylic acids. However, those of despite their excellent properties compare to other alloys, some specific oil and gas parts such as the sensitive areas of some sensors may require a special attention as high pressure high temperature (HPHT) environment, corrosion and abrasion may affect their performances in the long term. Additionally, oil and gas sensors may often be exposed, during the same drilling work, to various drilling fluids containing hydrophilic solid particles or heavy molecules such as asphaltenes, resins or heavy alkanes which tend to aggregate on hydrophilic alloy surfaces. Diamond coatings have thus been identified as attractive candidates to protect sensor used during drilling operations. Indeed, diamond materials due to their excellent hardness and wear, low friction coefficient, corrosion resilience and chemical inertness further to high natural resilience to fouling are especially suitable to be used in harsh environments. However, diamond coating on Ni-alloy such as Inconel could not be done by MP-CVD common processes. The current study has proposed solutions, and namely the development of three different processes aiming at a strong and adherent diamond coating on Inconel718. These three processes differ by their roughness and their difficulties of implementation. Their advantages for density-viscosity sensors have been assessed in various drilling fluids, and two specific approaches have been identified as particularly promising to mitigate fouling, namely (i) to create a diamond superhydrophobic surface through micro-structuration to get the antifouling Lotus properties, and (ii) the optimization of an electrochemical treatment aiming at cleaning in situ the diamond surfaces downhole. This study has led to propose reaction mechanisms and demonstrated the role of degraded water on the electrochemical treatment. The thesis has demonstrated the potentialities and identified the limits of those approaches. Efficiency of the electrochemical process applied to drilling fluids and crude oils fouling have been successively demonstrated
Erignoux, Clément. "Limite hydrodynamique pour un dynamique sur réseau de particules actives." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLX011/document.
Повний текст джерелаCollective dynamics can be observed among many animal species, and have given rise in the last decades to an active and interdisciplinary field of study. Such behaviors are usually modeled by active matter, in which each individual is self-driven and tends to align its velocity with that of its neighbors.In a classical model introduced by Vicsek & al., as well as in numerous related active matter models, a phase transition between chaotic behavior at high temperature and global order at low temperature can be observed. Even though ample evidence of these phase transitions has been obtained for collective dynamics, from a mathematical standpoint, such active systems are not fully understood yet. Some progress has been achieved in the recent years under an assumption of mean-field interactions, however to this day, few rigorous results have been obtained for models involving purely local interactions.In this manuscript, we describe a lattice active particle system interacting locally to align their velocities. This thesis aims at rigorously obtaining, using the formalism developed for hydrodynamic limits of lattice gases, the scaling limit of this out-of-equilibrium system, for which numerous technical and theoretical difficulties arise
Prévost, Hervé. "Commencer à gagner sa vie sans la perdre : recherche sur le premier cours de la vie professionnelle /." Paris ; Budapest ; Kinshasa [etc.] : l'Harmattan, 2005. http://catalogue.bnf.fr/ark:/12148/cb40040040j.
Повний текст джерелаKleyn, Eugene Lyle. "The Internal Validation and Casework Application of MiniSTR Systems." Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9575_1260194549.
Повний текст джерелаThe objective of the study was to conduct an internal validation on miniSTR systems and apply it to cases received from the South African Missing Persons Task Team (SAMPTT). This was prompted by the fact that miniSTR systems have been shown to out perform some of the commercial kits available in the time of the study and provide an alternative to mtDNA when analysing degraded DNA from skeletal remains and that the DNA extracted from skeletal remains received from the SAMPTT would be degraded due to the remains generally being fragmented or charred and buried for many years. The miniSTR loci chosen for validation comprised the Combined DNA Index System (CODIS) thirteen core loci and were arranged into four triplexes and one uniplex.
Coldefy, Hélène. "Contrôle non invasif de l'hyperthermie par imagerie microonde active : étude préliminaire sur fantôme homogène." Paris 11, 1986. http://www.theses.fr/1986PA112012.
Повний текст джерелаChampigny, Guy. "Caracterisation ionique d'un courant entrant active en hyperpolarisation sur le sinus veineux de batracien." Poitiers, 1987. http://www.theses.fr/1987POIT2281.
Повний текст джерелаEL, HANI AMHED. "Etude physico-chimique et biologique de la retention des substances humiques sur charbon active." Limoges, 1987. http://www.theses.fr/1987LIMO0019.
Повний текст джерелаSabac, Andrei. "Etude, réalisation et caractérisation d'un microinterféromètre de Mach-Zehnder intégré sur membrane silicium active." Besançon, 2004. http://www.theses.fr/2004BESA2059.
Повний текст джерелаPIGNON, METIVIER HELENE. "Procedes de traitement d'eau par adsorption sur tissus de carbone active couplage ultrafiltration - adsorption." Nantes, 2001. http://www.theses.fr/2001NANT2038.
Повний текст джерелаColdefy, Hélène. "Contrôle non invasif de l'hyperthermie par imagerie microonde active étude préliminaire sur fantôme homogène." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb375967849.
Повний текст джерелаHanna, Nohra Antoine. "Commande de filtres actifs parallèles sur un réseau fortement perturbé." Phd thesis, Toulouse, INPT, 2017. http://oatao.univ-toulouse.fr/17708/1/hanna-nohra.pdf.
Повний текст джерелаWolfson, Shael Nathan. "Market Reaction to the Class Action Fairness Act of 2005." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1116.
Повний текст джерелаRizza, Magali. "Analyses des vitesses et des déplacements cosismiques sur des failles décrochantes en Mongolie et en Iran : approche morphotectonique et paléosismologique." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20202/document.
Повний текст джерелаThe aim of this thesis is to analyze if variations in slip rates occur along strike-slip faults, in intracontinental domain, these faults producing large earthquakes (M> 7.5). To illustrate these variations, this work has focused in two area located in the most tectonically active continental domains in the world: in the western part of Mongolia (Bogd and Bulnay faults) and in the northern part of Iran (Astaneh and Tabriz faults). Using morphotectonic and paleoseismological analyses, the kinematics, the slip rates and the recurrence times have been estimated and allow us to describe the characteristics of seismic cycle along these faults. In Mongolia, the slip rates are estimated at ~1.2 and ~2.6 mm/yr along the Bogd and the Bulnay faults, respectively, with no variations of geological slip rates over the Pleistocene-Holocene period. These two faults present characteristic slips and similar recurrence times between large earthquakes. The paleoseismological investigations suggest that a cluster occurred 3000 years ago, similar to the seismic cluster recorded in Mongolia during the XX century. In Iran, the slip rate was estimated to 2 mm/yr along the Astaneh fault and the recurrence times are ranging from 1600 to 2200 years, associated with offsets comprised between 3 and 4.5 m. We have also estimated a slip rate of ~7 mm/yr along the Tabriz fault, in agreement with the present day rate estimated by GPS, suggesting no variations in the slip rate over the past 45 ka