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Статті в журналах з теми "Actimeter"

Автор: Grafiati

Опубліковано: 29 березня 2025

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1

Kumbol, Victor Wumbor-Apin, Elikplim Kwesi Ampofo, and Mary Ayeko Twumasi. "Actifield, an automated open source actimeter for rodents." HardwareX 4 (October 2018): e00047. http://dx.doi.org/10.1016/j.ohx.2018.e00047.

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2

Röösli, Martin, Mark Brink, Franziska Rudzik, Christian Cajochen, Martina S. Ragettli, Benjamin Flückiger, Reto Pieren, Danielle Vienneau, and Jean-Marc Wunderli. "Associations of Various Nighttime Noise Exposure Indicators with Objective Sleep Efficiency and Self-Reported Sleep Quality: A Field Study." International Journal of Environmental Research and Public Health 16, no. 20 (October 9, 2019): 3790. http://dx.doi.org/10.3390/ijerph16203790.

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It is unclear which noise exposure time window and noise characteristics during nighttime are most detrimental for sleep quality in real-life settings. We conducted a field study with 105 volunteers wearing a wrist actimeter to record their sleep during seven days, together with concurrent outdoor noise measurements at their bedroom window. Actimetry-recorded sleep latency increased by 5.6 min (95% confidence interval (CI): 1.6 to 9.6 min) per 10 dB(A) increase in noise exposure during the first hour after bedtime. Actimetry-assessed sleep efficiency was significantly reduced by 2%–3% per 10 dB(A) increase in measured outdoor noise (Leq, 1h) for the last three hours of sleep. For self-reported sleepiness, noise exposure during the last hour prior to wake-up was most crucial, with an increase in the sleepiness score of 0.31 units (95% CI: 0.08 to 0.54) per 10 dB(A) Leq,1h. Associations for estimated indoor noise were not more pronounced than for outdoor noise. Taking noise events into consideration in addition to equivalent sound pressure levels (Leq) only marginally improved the statistical models. Our study provides evidence that matching the nighttime noise exposure time window to the individual’s diurnal sleep–wake pattern results in a better estimate of detrimental nighttime noise effects on sleep. We found that noise exposure at the beginning and the end of the sleep is most crucial for sleep quality.

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3

Borisenkov, Mikhail, Tatyana Tserne, Larisa Bakutova, and Denis Gubin. "Actimetry-Derived 24 h Rest–Activity Rhythm Indices Applied to Predict MCTQ and PSQI." Applied Sciences 12, no. 14 (July 7, 2022): 6888. http://dx.doi.org/10.3390/app12146888.

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The aim of this study was to identify wrist actimetry-based indices associated with the sleep–wake rhythm characteristics of healthy individuals. The study involved 79 healthy subjects of both sexes (age range 15–62 years (mean: 21.5 ± 9.6 years, women: 77.8%)). Each participant provided personal data, filled out two questionnaires, the Munich ChronoType Questionnaire (MCTQ) and the Pittsburgh Sleep Quality Index (PSQI), and wore a wrist actimeter for a week. A significant positive association of the chronotype with the mid-phase of the most active 10 h period (M10t: B = 0.252, p = 0.015), the mid-phase of the least active 5 h period (L5t: B = 0.338, p = 0.005), and the interdaily stability (IS: B = −0.021, p = 0.017) was noted, as well as the sleep duration with the M10t (B = −0.257, p = 0.003), L5t (B = −0.340, p = 0.001), and IS (B = 0.042, p = 0.003). There was a significant association of social jetlag (B = 0.320, p = 0.032) and sleep quality (B = 0.990, p = 0.013) with motor activity in bed, as well as sleep efficiency with the acrophase (B = −0.043, p = 0.007). Nonparametric indices of the 24 h rest–activity rhythm are useful tools for assessing the sleep–wake rhythm of healthy individuals.

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4

Parker, Gordon, Gemma Gladstone, and Dusan Hadzi-Pavlovic. "Measuring psychomotor agitation by use of an actimeter: a pilot study." Journal of Affective Disorders 72, no. 1 (October 2002): 91–94. http://dx.doi.org/10.1016/s0165-0327(01)00426-8.

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5

Chardonnet, F., P. Martínez Takegami, B. Chouquet, J. F. Silvain, and L. Kaiser. "An actimeter system for automated recording of foraging activity in stem borer caterpillars." Entomologia Experimentalis et Applicata 142, no. 2 (January 9, 2012): 175–80. http://dx.doi.org/10.1111/j.1570-7458.2011.01212.x.

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6

Mititelu-Tartau, Liliana, Maria Bogdan, Liliana Lăcrămioara Pavel, Ciprian Rezus, Cezar Ilie Foia, Nicoleta Dima, Irina Luciana Gurzu, Ana-Maria Pelin, and Beatrice Rozalina Buca. "Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats." Life 14, no. 3 (February 26, 2024): 306. http://dx.doi.org/10.3390/life14030306.

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Compelling evidence indicates that nitric oxide (NO) exerts a significant influence on the central nervous system, participates in the modulation of neurotransmitter release, contributes to the regulation of cognitive functions, and plays a crucial role in modulating various aspects of neural activity. We aimed to explore the influence of two NO donors, molsidomine (MSD) and V-pyrro/NO, on the innate spontaneous psychomotor abilities and short-term memory in rats. Using an actimeter test, the locomotor activity, stress-sensitive behavior, and anxiety level were investigated. The influence on the animal`s cognitive functions was evaluated usingthe Y-maze test to assess the spontaneous alternation percentage, number of arms visited, number of alternations, and the preference index. Four distinct groups of five white male Wistar rats were exposed to the intraperitoneal treatments as follows: Control batch—0.3 mL/100 g of body weight saline solution, Mg batch—200 mg/kbwof magnesium chloride, MSD batch—1 mg/kbw of molsidomine, and V-pyrro/NO batch—5 mg/kbwof V-pyrro/NO. The intraperitoneal administration of MSD resulted in a significant reduction in spontaneous behavior and exploratory skills but was less pronounced than the positive control drug, magnesium chloride. Conversely, treatment with V-pyrro/NO led to only a slight decrease in horizontal movements during the actimeter test. MSD administration, but not V-pyrro/NO, notably increased the rate of spontaneous alternation in the Y-maze test. Additionally, the use of MSD resulted in an increase in the blood level of brain-derived neurotrophic factor and the intensification of the antioxidant enzymes, superoxide dismutase, and glutathione peroxidase activity. In our experimental setup, we demonstrated that MSD exposure led to a decrease in spontaneous behavior, showed anxiolytic effects and antioxidant activity, and improved spatial memory acquisition in rats.

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7

Øverland, Britt, Guttorm Bruskeland, Harriet Akre, and Olav Skatvedt. "Evaluation of a Portable Recording Device (Reggie) with Actimeter and Nasopharyngeal/Esophagus Catheter Incorporated." Respiration 72, no. 6 (2005): 600–605. http://dx.doi.org/10.1159/000086722.

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8

Compagnat, M., S. Mandigout, C. S. Batcho, N. Vuillerme, J. Y. Salle, R. David, and J. C. Daviet. "Validity of wearable actimeter computation of total energy expenditure during walking in post-stroke individuals." Annals of Physical and Rehabilitation Medicine 63, no. 3 (May 2020): 209–15. http://dx.doi.org/10.1016/j.rehab.2019.07.002.

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9

Bhuachalla, Blaithin Ni, Suzanne Walsh, and Joseph Harbison. "Actimeter-Derived Sleep and Wake Data and Nocturnal Ambulatory Blood Pressure Estimation in Subjects with Stroke and Transient Ischaemic Attack." International Journal of Stroke 6, no. 5 (April 18, 2011): 388–91. http://dx.doi.org/10.1111/j.1747-4949.2011.00593.x.

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10

Bravo, Rafael, Sergio Matito, Javier Cubero, Lourdes Franco, Cristina Sánchez, Ana B. Rodríguez, Montserrat Rivero, and Carmen Barriga. "Assessment of the intake of tryptophan-enriched cereals in the elderly and its influence on the sleep-wake circadian rhythm." Antropologia Portuguesa, no. 29 (June 6, 2012): 113–20. http://dx.doi.org/10.14195/2182-7982_29_8.

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Sleep-wake circadian rhythm disturbances are a common problem associated to aging. Although this problem can be caused by several factors, low levels of the indol melatonin are related with these alterations. Our aim was to evaluate if the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, can enhance sleep problems in elderly people. Participants (n=12; aged 55-67 yr) were selected from Elderly people University of The University of Extremadura. During all the assay participants wore a wrist actimeter and they filled every week an STAI anxiety test. Data were collected following this schedule: Control week: participants ingested a control cereal both at breakfast anddinner (22.5 mg tryptophan/ 30g product per dose); Treatment Week: volunteers consumed a tryptophan enriched cereal both at breakfast and dinner (60mg tryptophan/30g product per dose); Post-treatment week: participants ingested their habitual diet. We observed a decrease in sleep latency (p<0.01), wake bouts (p>0.05) and sleep fragmentation (p<0.001); on the other hand, an increase in actual sleep time (p<0.01), sleep efficiency (p<0.01) and immobile time (p<0.01) were detected. With respect to the anxiety test, there was an improvement in the state of anxiety. In conclusion, through a tryptophanenriched diet age related sleep problems can be improved.

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11

Chajka, A. V., D. R. Khusainov, and K. N. Tumanyants. "POSSIBLE ANTI-DEPRESSANT EFFECT OF THE SELECTIVE COX-2 INHIBITOR MELOXICAM, ITS RELATIONSHIP WITH THE DOPAMINERGIC BRAIN SYSTEM." Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry 7 (73), no. 1 (2021): 229–42. http://dx.doi.org/10.37279/2413-1725-2021-7-1-229-242.

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Inflammation is now believed to play an important role in the development of depression, and it is suggested that inflammation may be a promising target for the treatment and prevention of mood disorders. It is not surprising that various non-steroidal anti-inflammatory drugs (NSAIDs), including selective inhibitors of cyclooxygenase-2 (COX-2), are being tested for their antidepressant properties. At the same time, it is known that inhibition of COX-2 has a certain effect on the dopaminergic (DA) system. However, in the literature, there are also opposite opinions on this matter, for example, that the neuroprotective effect of NSAIDs is associated not with COX-2, but with the PI3K/Akt signaling pathway, and inhibition of COX-2 does not have a neuroprotective effect, and even negatively affects the central nervous system up to until the pathophysiology of depression aggravates. Therefore, the question of the antidepressant properties of COX-2 inhibitors remains open for further research. In addition, because of the dynamic nature of depression, it is important to ascertain whether NSAIDs may be prophylactic in the early stages of depression. Accordingly, the aim of this study was to determine the presence or absence of antidepressant potential in the selective COX-2 inhibitor meloxicam (21 days, 1 mg/kg), its possible relationship with the DA system, by tracing these effects over time. The combined use of meloxicam and haloperidol (24 days, 2.5 mg kg) in the first 7 days of the experiment did not significantly affect the level of immobility of rats in the «Forced swim test», but on days 8, 12–19, and 21 of the experiment, the level of immobility in this the group was significantly higher than in the haloperidol group. The administration of meloxicam also failed to reverse the negative effects of stress: on days 1–5, 7–12 and 15–19, there were no differences between the groups in the level of immobility, and on days 6, 13–14 and 20-21, meloxicam even increased immobility by compared with the stress group. Another evidence in favor of the depressant effect of meloxicam is the fact that it increases the level of immobility in intact rats, while the MAO inhibitor selegiline (24 days, 3 mg/kg), on the contrary, does not affect the level of immobility – the data are indistinguishable from control. Meloxicam also failed to increase locomotor activity in rats in the «Actimeter», suppressed by the combined use of haloperidol and stress. The positive effect of meloxicam was manifested only in the improvement of the task performance on the Rotarod against the background of D2-receptor blockade. Inhibition of COX-2 by meloxicam did not have the expected antidepressant effect in the «Forced swim test» and «Actimeter», but, on the contrary, led to a worsens emotional state of the animals. At the behavioral level, we were unable to obtain convincing evidence of a direct connection between the effects of meloxicam and the functioning of the DA system, although its activating effect on animal locomotion in the Rotarod test after blockade of D2-receptors with haloperidol was established.

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12

Funabashi, Daisuke, Yusuke Wakiyama, Naoya Muto, Ichiro Kita, and Takeshi Nishijima. "Social isolation is a direct determinant of decreased home‐cage activity in mice: A within‐subjects study using a body‐implantable actimeter." Experimental Physiology 107, no. 2 (January 11, 2022): 133–46. http://dx.doi.org/10.1113/ep090132.

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13

Awad, Kamal, Logan Moore, Jian Huang, Leticia Brotto, and Marco Brotto. "CAN ACUTE MUSCLE DAMAGE LEAD TO OSTEOARTHRITIS?" Innovation in Aging 7, Supplement_1 (December 1, 2023): 768. http://dx.doi.org/10.1093/geroni/igad104.2481.

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Abstract Skeletal muscles are crucial for maintaining musculoskeletal homeostasis, as they provide mechanical support, joint stability, and biochemical functions via myokine secretion. We investigated whether acute muscle damage or weakness could contribute to the development of osteoarthritis (OA). Using a chemical damage model, we induced muscle damage by injecting 1.2% barium chloride into the tibialis anterior muscle, resulting in an immune response characterized by a significant increase in the concentration of Prostaglandin E2 (PGE2) and other lipid mediators derived from the EPA and DHA signaling pathways, as quantified using our innovative lipidomics methods. The muscle damage was confirmed and visualized by muscle histomorphometry. The damage resulted in muscle weakness, detected by a significant decrease in grip strength at 4-days post-injury, but without changes in mice activity measured with force-plate actimeter. After 1-month post-injury, grip strength and muscle histology returned to normal, but histological changes were observed in the articulating cartilage, indicating surface erosion and cartilage matrix loss (OARSI grade 4). We used Raman Spectroscopy and micro-CT to confirm the joint alterations observed in the changes in subchondral bone and increased bone volume fraction in the cortical shell of the subchondral bone, respectively, features characteristic of OA in rodents and humans. These findings suggest that muscle weakness or imbalance due to injury can contribute to joint degeneration. This study highlights the significance of muscles in preventing OA and provides a novel approach for exploring the relationship between muscle damage and OA development. This new model could prove valuable for aging research.

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14

Gräfitsch, Alexander, Philipp Kirchhoff, Henry Hoffmann, Ralph F. Staerkle, Savas D. Soysal, and Philippe M. Glauser. "Perioperative Tablet-Based Telemonitoring After Abdominal Wall Hernia Surgery: Pilot Prospective Observational Cohort Study." JMIR Perioperative Medicine 3, no. 2 (October 20, 2020): e15672. http://dx.doi.org/10.2196/15672.

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Background Hernia repairs account for millions of general surgical procedures performed each year worldwide, with a notable shift to outpatient settings over the last decades. As technical possibilities such as smartphones, tablets, and different kinds of probes are becoming more and more available, such systems have been evaluated for applications in various clinical settings. However, there have been few studies conducted in the surgical field, especially in general surgery. Objective We aimed to assess the feasibility of a tablet-based follow up to monitor activity levels after repair of abdominal wall hernias and to evaluate a possible reduction of adverse events by their earlier recognition. Methods Patients scheduled for elective surgical repair of minor abdominal wall hernias (eg, inguinal, umbilical, or trocar hernias) were equipped with a telemonitoring system, including a tablet, pulse oximeter, and actimeter, for a monitoring phase of 7 days before and 30 days after surgery. Descriptive statistical analyses were performed. Results We enrolled 16 patients with a mean overall age of 48.75 (SD 16.27) years. Preoperative activity levels were reached on postoperative day 12 with a median of 2242 (IQR 0-4578) steps after plunging on the day of surgery. The median proportion of available activity measurements over the entire study period of 38 days was 69% (IQR 56%-81%). We observed a gradual decrease in the proportion of available data for all parameters during the postoperative course. Six out of ten patients (60%) regained preoperative activity levels within 3 weeks after surgery. Overall, patients rated the usability of the system as relatively easy. Conclusions Tablet-based follow up is feasible after surgical repair of minor abdominal wall hernias, with good adherence rates during the first couple of weeks after surgery. Thus, such a system could be a useful tool to supplement or even replace traditional outpatient follow up in selected general surgical patients.

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15

Reyner, L., J. E. Miller, and T. Shea. "0468 A Multiple Dose, Placebo-Controlled, Randomized Double-Blind, Multicenter Study to Investigate Triprolidine in the Treatment of Temporary Sleep Disturbance." Sleep 43, Supplement_1 (April 2020): A179—A180. http://dx.doi.org/10.1093/sleep/zsaa056.465.

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Abstract Introduction American Association of Sleep Medicine guidelines states that the primary goals of the treatment of insomnia are to improve sleep quality and related daytime function. While H1 antihistamines have sedative effects, they are associated with residual daytime sleepiness and an effective dose range for hypnotic effect has hitherto not been established. Triprolidine a first generation antihistamine used to treat allergic rhinitis and the common cold has a mean half-life of 3.2 hours. We evaluated the effect of two doses of triprolodine compared with placebo on sleep onset latency and daytime sleepiness to determine the optimum dose in subjects with temporary sleep disturbance. Methods Multicenter, placebo-controlled, parallel group, double blind, multiple dose, randomized study of 178 patients aged 18 years or above with a primary diagnosis of temporary sleep disturbance. Patients were randomized to one of three groups. Group 1: 2 x placebo tablets; Group 2: 1 x placebo tablet + 1 x 2.5mg triprolidine tablet; Group 3: 2 x 2.5mg triprolodine tablets, taken 20 minutes before intended sleep on three consecutive evenings. Efficacy was measured objectively using the Sleep Disturbance Index using a wrist actimeter and subjectively using the Loughborough Sleep Log and Karolinska Sleepiness Scale. Results Both doses were statistically significantly superior to placebo in terms of quality and duration of sleep and sleep interruptions. No hangover effects or daytime sleepiness were observed with either dose compared to placebo. Patients on the 2.5 mg dose awoke more refreshed than the 5 mg dose. No serious adverse effects observed in any group and anticholinergic events i.e. dry mouth were very low. Conclusion Tripolidine is effective and safe in the treatment of temporary sleep disturbance. The optimum dose is 2.5mg. Support The study was sponsored by Boots Healthcare International.

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16

Batool, Sadia, Haneen Saeed, Sarah Yehya, Rasha Ali, Afia Mofreh, and Hanaa Saeed. "Evaluation of Antidepressant Potential of Hydrastis canadensis in Mice." Open Access Macedonian Journal of Medical Sciences 8, A (August 20, 2020): 589–92. http://dx.doi.org/10.3889/oamjms.2020.4903.

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BACKGROUND: Depression is one of the most common chronic psychological disorders around the world presenting with many interpersonal and social problems. Common antidepressants have various adverse effects and are not safe for long-term therapy. Alternative safer remedies are under investigation with a focus on herbal therapies. Hydrastis canadensis is a perennial herb, rich in many phytoconstituents ranging from amino acids to alkaloids, flavonoids, and steroids. It is also widely used in Chinese folklore tradition for mood elevating effects; however, this has not been scientifically proven. AIM: This study is thus aimed at evaluating antidepressant potential of this plant. MATERIALS AND METHODS: Ethanolic extract of dried root of plant was prepared by maceration technique and was subjected to phytochemical screening. Mice were divided into four groups (n = 5). Tween 80, 2 ml (negative control), fluoxetine 10 mg/kg (positive control), and extracts at 150 mg/kg and 250 mg/kg were administered by intraperitoneal route to mice in their respective groups. The locomotor activity was assessed for 5 min using actimeter at 0, 30, and 60 min for each animal. Increase in locomotion was an index of antidepressant effect. The mean value of each group was calculated and results were compared by one-way ANOVA. p < 0.05 was considered statistically significant. RESULTS: Phytochemical screening yielded positive results for alkaloids and saponins. Locomotion was increased in groups treated with fluoxetine and extract at 150 mg and 250 mg/kg dose when compared to negative control (1% – Tween 80). This was an index of antidepressant effect. However, the results were statistically significant (p < 0.05) for fluoxetine and extract treated groups at 250 mg/kg. Fluoxetine demonstrated the highest antidepressant effect. CONCLUSION: This study has demonstrated the antidepressant potential of Hydrastis canadensis ethanolic extract. Further studies are required to validate these findings on other experimental models. The specific active constituent and effects at cellular level need to be evaluated.

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17

Goldfine, Andrew M., Behdad Dehbandi, Juliana M. Kennedy, Briana Sabot, Cory Semper, and David Putrino. "Quantifying Poststroke Apathy With Actimeters." Journal of Neuropsychiatry and Clinical Neurosciences 28, no. 3 (July 2016): 199–204. http://dx.doi.org/10.1176/appi.neuropsych.15090235.

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18

Burgaz, Sonia, Concepción García, Maria Gómez-Cañas, Eduardo Muñoz та Javier Fernández-Ruiz. "Development of An Oral Treatment with the PPAR-γ-Acting Cannabinoid VCE-003.2 Against the Inflammation-Driven Neuronal Deterioration in Experimental Parkinson’s Disease". Molecules 24, № 15 (25 липня 2019): 2702. http://dx.doi.org/10.3390/molecules24152702.

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In a recent study, we described the neuroprotective properties of VCE-003.2—an aminoquinone derivative of the non-psychotropic phytocannabinoid cannabigerol (CBG)—administered intraperitoneally (i.p.) in an inflammatory model of Parkinson’s disease (PD). We also demonstrated that these properties derive from its activity on the peroxisome proliferator-activated receptor-γ, in particular at a regulatory site within this receptor type. In the present study, we wanted to further confirm this neuroprotective potential using an oral lipid formulation of VCE-003.2, developed to facilitate the clinical development of this phytocannabinoid derivative. To this end, we evaluated VCE-003.2, administered orally at two doses (10 and 20 mg/kg), to mice subjected to unilateral intrastriatal injections of lipopolysaccharide (LPS), a classic model of inflammation-driven neuronal deterioration that recapitulates characteristics of PD. The administration of VCE-003.2 to these mice showed, as expected, poor activity in the different motor tests (rotarod, computer-aided actimeter) used in experimental parkinsonism, in general due to the lack of evident changes in these behaviors by LPS lesion. However, VCE-003.2, at 20 mg/kg, was highly active in improving the changes detected in LPS-lesioned mice in the cylinder rearing test. In addition, the histopathological analysis of the basal ganglia revealed a trend towards recovery at 20 mg/kg VCE-003.2 in the loss of tyrosine hydroxylase-containing nigrostriatal neurons, as well as a complete reduction in the elevated LAMP-1 immunolabeling (reflecting autophagy impairment) caused by LPS lesion. These effects were not seen at 10 mg/kg. This was associated with a partial reduction in the intense glial reactivity provoked by LPS in the substantia nigra, in particular the astroglial reactivity labeled with glial fibrillary acidic protein. The analysis using qPCR in the striatum of proinflammatory mediators, such as tumor necrosis factor-α, interleukin-1β, inducible nitric oxide synthase, and cyclooxygenase-2, showed that the marked elevations provoked by the LPS lesion tended to be, in general, attenuated by VCE-003.2 treatment, with the greatest effects normally found with the highest dose of 20 mg/kg. In summary, our data confirm the neuroprotective potential of an oral formulation of VCE-003.2 against neuronal injury in an in vivo model of PD based on neuroinflammation, and this study opens the possibility to further the development of oral VCE-003.2 in the clinic.

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19

Kellner, O., H. Bastuji, and P. Adeleine. "Actimetry in sleep medicine." Sleep & Breathing 2, no. 1 (March 1997): 33–39. http://dx.doi.org/10.1007/bf03038855.

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20

Couturier, Pascal, Alain Franco, and Alain Buguet. "Body actimetry to warn of pressure sores." Lancet 347, no. 9001 (March 1996): 627. http://dx.doi.org/10.1016/s0140-6736(96)91333-1.

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21

Robert, G. "Cerebral networks of apathy and goal-oriented patterns of actimetry in late-life depression." European Psychiatry 66, S1 (March 2023): S11—S12. http://dx.doi.org/10.1192/j.eurpsy.2023.53.

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Abstract Apathy and goal-oriented behaviors are key dimensions of late-life depression (LLD) and are iteratively associated with cognitive decline in most neuropsychiatric disorders. However, scales and criteria remains insufficient to provide robust individual biomarkers that could foster personalized therapeutic approaches. Therefore, dimensional and digital phenotyping offer new possibilities of stratifying LLD population. This presentation will show our recent results of functional connectivity cerebral networks associated with multidimensional paper-and-pen measures of apathy, including the default mode and the cingulo-opercular networks. We will also show how dimensional reduction (functional principal component analysis) of 3 days actimetry measures are associated with both FC and inflammatory measures (diffusion and multicompartment indices such as free water and neurite orientation dispersion), providing arguments for different pathophysiological mechanisms underlying goal-oriented behaviors and reinforcing actimetry as a good candidate for individual biomarker of cognitive decline in LLD. Finally, machine learning approaches using combination of different, yet correlated, indices of actimetry will be presented and discussed with their corresponding classifying accuracies (outside of cerebral imaging). Altogether, this presentation aims at bridging the gap between cerebral imaging and digital phenotyping to enhance personalized medicine in the field of old-age psychiatry and cognitive decline prevention. Disclosure of Interest None Declared

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22

Luz, George, Edward Nykaza, Catherine Stewart, and Larry Pater. "Use of actimeters to determine awakenings by sounds of large guns." Noise Control Engineering Journal 56, no. 3 (May 1, 2008): 211–17. http://dx.doi.org/10.3397/1.2938736.

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23

Ritter, Philipp S., Cathrin Sauer, Steffi Pfeiffer, Michael Bauer, and Andrea Pfennig. "Comparison of Subjective and Objective Sleep Estimations in Patients with Bipolar Disorder and Healthy Control Subjects." Sleep Disorders 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/4031535.

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Background. Several studies have described but not formally tested discrepancies between subjective and objective measures of sleep.Study Objectives. To test the hypothesis that patients with bipolar disorder display a systematic bias to underestimate sleep duration and overestimate sleep latency.Methods. Actimetry was used to assess sleep latency and duration in 49 euthymic participants (bipolar = 21; healthy controls = 28) for 5–7 days. Participants simultaneously recorded estimated sleep duration and sleep latency on a daily basis via an online sleep diary. Group differences in the discrepancy between subjective and objective parameters were calculated usingt-tests and corrected for multiple comparisons.Results. Patients with bipolar disorder significantly underestimated their sleep duration but did not overestimate their sleep latency compared to healthy controls.Conclusions. Studies utilizing diaries or questionnaires alone in patients with bipolar disorders may systematically underestimate sleep duration compared to healthy controls. The additional use of objective assessment methods such as actimetry is advisable.

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Wardas, Jadwiga, Urszula Głowacka, Katarzyna Kuter, Klemencja Berghauzen-Maciejewska, and Krystyna Ossowska. "Apomorphine enhances the tremor induced by harmaline; automatic measurements by force plate actimeters." Pharmacological Reports 65 (May 2013): 95–96. http://dx.doi.org/10.1016/s1734-1140(13)71402-6.

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Wilson, C., M. Rees, K. Kee, J. Stonehouse, and A. Perkins. "P033 Validation of GENEActiv actimeters and Cicada Actigraphy Suite in a clinical sleep laboratory setting." Sleep Advances 5, Supplement_1 (October 2024): A40—A41. https://doi.org/10.1093/sleepadvances/zpae070.115.

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Abstract Introduction The use of Actigraphy in clinical settings is an established approach, with the American Academy of Sleep Medicine (AASM) describing actigraphy as a suggested aid in the diagnosis of multiple sleep disorders such as delayed sleep phase syndrome, narcolepsy and insomnia. Aim The purpose of this study was to review the validity of the GENEActiv accelerometer (Activinsights, Kimbolton, UK) and Cicada Actigraphy Suite (Rick Wassing) in the setting of clinical practice and to optimise settings to align with gold-standard PSG. Methods Actigraphy data of 60 patients using GENEActiv were reviewed against concurrent overnight PSGs. Actiwatch data was compared to PSG metrics of Total Sleep Time (TST), Sleep Efficiency (SE), Sleep Latency (SL) and WASO. Using the open-source GGIR algorithm, the default Cicada 5-Sec epoch was measured against a 30-Sec epoch length comparable with PSG. Results For both epoch durations and following Boneferroni correction (α=0.016), TST and SE were shown to be significantly over-calculated while SL was under-calculated compared to PSG. When comparing epoch lengths WASO times were closer to PSG values when set to 5-second epochs (p>0.016). No other values were shown to be significantly different between the epoch lengths. Conclusion The results demonstrate that when compared to PSG, GENEactiv/Cicada settings markedly overestimate TST and SE and greatly underrepresent SL. While Actigraphy remains a beneficial aid in assisting diagnosis of sleep disorders, clear discrepancies are evident when compared to gold standard PSG. Appropriate clinical correlation should be encouraged when utilising GENEactiv & Cicada actigraphy in a clinical setting.

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Augustynek, Martin, LukáŜ Ĉajka, and Vladimir KaŜik. "Measurement, signal processing and visualisation of actimetry, electrocardiography and body temperature." IFAC Proceedings Volumes 42, no. 1 (2009): 282–85. http://dx.doi.org/10.3182/20090210-3-cz-4002.00057.

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Gonçalves, BSB, Taísa Adamowicz, Fernando Mazzilli Louzada, Claudia Roberta Moreno, and John Fontenele Araujo. "A fresh look at the use of nonparametric analysis in actimetry." Sleep Medicine Reviews 20 (April 2015): 84–91. http://dx.doi.org/10.1016/j.smrv.2014.06.002.

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Montain, Scott J., Carol J. Baker-Fulco, Philip J. Niro, Andrew Reinert, Joseph Domitrovich, and Brent C. Ruby. "Eat-On-Move Rations Improve Actimetry Scores During Wildland Fire Suppression." Medicine & Science in Sports & Exercise 38, Supplement (May 2006): S36. http://dx.doi.org/10.1249/00005768-200605001-01041.

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Delsart, Aliénor, Colombe Otis, Vivian S. Y. Leung, Émilie Labelle, Maxim Moreau, Marilyn Frezier, Marlene Drag, Johanne Martel-Pelletier, Jean-Pierre Pelletier, and Eric Troncy. "Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study." Animals 14, no. 5 (February 24, 2024): 711. http://dx.doi.org/10.3390/ani14050711.

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Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA (n = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr. A: 0.40; B: 0.25; C: 0.15, and P: 0.00 mg/kg bodyweight). They were assessed during Baseline, Treatment, and Recovery periods using MI-CAT(V) and objective outcomes (effort path, stairs assay compliance, and actimetry). The MI-CAT(V) total score correlated to the effort path and actimetry (RhoS = −0.501 to −0.453; p < 0.001), also being sensitive to treatment responsiveness. The pooled treatment group improved its total, gait, and body posture scores during Treatment compared to the Baseline, Recovery, and placebo group (p < 0.05). The MI-CAT(V) suggested a dose-(especially for Gr. B) and cluster-response. Cats in the moderate and severe MI-CAT(V) clusters responded to firocoxib with a remaining analgesic effect, while the mild cluster seemed less responsive and experienced a negative rebound effect. The MI-CAT(V) was validated for its OA pain severity discriminatory abilities and sensitivity to firocoxib treatment, providing a new perspective for individualized care.

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Bazin, Thomas, Jean-Arthur Micoulaud Franchi, Nathalie Terras, Jacques Taillard, David Laharie, Frank Zerbib, and Pierre Philip. "Altered sleep quality is associated with Crohn’s disease activity: an actimetry study." Sleep and Breathing 24, no. 3 (September 12, 2019): 971–77. http://dx.doi.org/10.1007/s11325-019-01934-z.

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Carvalho Bos, Sandra, James Waterhouse, Ben Edwards, Ries Simons, and Thomas Reilly. "The Use of Actimetry to Assess Changes to the Rest–Activity Cycle." Chronobiology International 20, no. 6 (January 2003): 1039–59. http://dx.doi.org/10.1081/cbi-120025397.

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Lersch, Friedrich, Pascal Jerney, Heiko Kaiser, Cédric Willi, Katharina Steck, Darren Hight, and Frédéric Zubler. "Actimetry-Documented Persistent Periodic Limb Movements During EEG-Confirmed Deep General Anesthesia." A & A Practice 14, no. 6 (April 2020): e01183. http://dx.doi.org/10.1213/xaa.0000000000001183.

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Wang, David, Keith K. Wong, George C. Dungan, Peter R. Buchanan, Brendon J. Yee, and Ronald R. Grunstein. "The Validity of Wrist Actimetry Assessment of Sleep With and Without Sleep Apnea." Journal of Clinical Sleep Medicine 04, no. 05 (October 15, 2008): 450–55. http://dx.doi.org/10.5664/jcsm.27281.

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Lévi, Francis, Pierre-Antoine Dugué, Pasquale Innominato, Abdoulaye Karaboué, Garance Dispersyn, Arti Parganiha, Sylvie Giacchetti, et al. "Wrist actimetry circadian rhythm as a robust predictor of colorectal cancer patients survival." Chronobiology International 31, no. 8 (June 13, 2014): 891–900. http://dx.doi.org/10.3109/07420528.2014.924523.

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ALLILAIRE, J. F., N. DANTCHEV, N. RAOUX, O. BENOIT, and D. WIDLOCHER. "ACTIMETRY: ITS CONTRIBUTION TO THE STUDY OF DEPRESSION. A SYNTHESIS OF THREE STUDIES." Clinical Neuropharmacology 15 (1992): 10B. http://dx.doi.org/10.1097/00002826-199202001-00019.

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Heulard, I., and M. Verleye. "Herbal medicinal products as an alternative for the treatment of minor sleep disorders and mild anxiety symptoms? Proof of concept in animal models." European Psychiatry 29, S3 (November 2014): 657. http://dx.doi.org/10.1016/j.eurpsy.2014.09.036.

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Herbal medicinal products have been traditionally used for the treatment of minor sleep disorders and mild anxiety symptoms. However, prospective clinical studies are scarce, due to a number of variability factors such as population heterogeneity and a strong placebo effect. To overcome these limitations, animal models are available that provide unbiased scientific results.In this study, we examined the effect of an association of four compounds [namely Melissa officinalis, Crataegus oxyancantha, calcium lactate and magnesium thiosulfate (32/30/32/6; w/w)], on several behavioral tests in rodents. Animals were tested for general activity on an automated actimetry system, and for anxiety on the so-called “staircase test”.In the actimetry test, adult mice were placed in an empty cage and their spontaneous level of activity (distance travelled and the number of rearings) was measured after an intraperitoneal administration of 25, 50 or 75 mg/kg of the association. A dose-dependent decrease of the distance travelled and number of rearings was observed after administration (statistically significant at the dose of 75 mg/kg). In the staircase test, the number of rearings (a measure of anxiety) and the number of steps climbed (general activity) were measured. A statistically significant decrease in the number of rearings was observed at the dose of 25 mg/kg (compared to vehicle-treated animals), whereas no effect in the number of steps climbed was observed at the same dose. These results suggest that the association could induce an anxiolytic effect. At higher doses, a sedative effect was observed.In conclusion, the administration of an association of Melissa officinalis, Crataegus oxyacantha, calcium and magnesium induced a clear dose-dependent sedative effect in mice. One test suggests that this association could also have anxiolytic properties. This study confirms that herbal medicinal products could be a beneficial treatment for minor sleep disorders or mild anxiety symptoms.

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Bac, P., N. Pages, P. Maurois, M. German-Fattal, and J. Durlach. "A new actimetry-based test of photic senzitization in a murine photosensitive magnesium depletion model." Methods and Findings in Experimental and Clinical Pharmacology 27, no. 10 (2005): 681. http://dx.doi.org/10.1358/mf.2005.27.10.948880.

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Collin, A., M. Grimee, and P. Y. Libois. "The actimetry as assessment method of patients’ compliance and effectiveness of constraint induced movement therapy." Annals of Physical and Rehabilitation Medicine 58 (September 2015): e8-e9. http://dx.doi.org/10.1016/j.rehab.2015.07.027.

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Ghotbi, Neda, Luísa K. Pilz, Eva C. Winnebeck, Céline Vetter, Giulia Zerbini, David Lenssen, Giovanni Frighetto, et al. "The µMCTQ: An Ultra-Short Version of the Munich ChronoType Questionnaire." Journal of Biological Rhythms 35, no. 1 (December 3, 2019): 98–110. http://dx.doi.org/10.1177/0748730419886986.

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Individuals vary in how their circadian system synchronizes with the cyclic environment (zeitgeber). Assessing these differences in “phase of entrainment”—often referred to as chronotype—is an important procedure in laboratory experiments and epidemiological studies but is also increasingly applied in circadian medicine, both in diagnosis and therapy. While biochemical measurements (e.g., dim-light melatonin onset [DLMO]) of internal time are still the gold standard, they are laborious, expensive, and mostly rely on special conditions (e.g., dim light). Chronotype estimation in the form of questionnaires is useful in approximating the timing of an individual’s circadian clock. They are simple, inexpensive, and location independent (e.g., administrable on- and offline) and can therefore be easily administered to many individuals. The Munich ChronoType Questionnaire (MCTQ) is an established instrument to assess chronotype by asking subjects about their sleep-wake-behavior. Here we present a shortened version of the MCTQ, the µMCTQ, for use in situations in which instrument length is critical, such as in large cohort studies. The µMCTQ contains only the core chronotype module of the standard MCTQ (stdMCTQ), which was shortened and adapted from 17 to 6 essential questions, allowing for a quick assessment of chronotype and other related parameters such as social jetlag and sleep duration. µMCTQ results correspond well to the ones collected by the stdMCTQ and are externally validated by actimetry and DLMO, assessed at home (no measure of compliance). Sleep onset, midpoint of sleep, and the µMCTQ-derived marker of chronotype showed slight deviations toward earlier times in the µMCTQ when compared with the stdMCTQ (<35 min). The µMCTQ assessment of chronotype showed good test-retest reliability and correlated significantly with phase markers from actimetry and melatonin (DLMO), especially with measurements taken on work-free days. Because of its brevity, the µMCTQ represents an ideal tool to estimate individual internal time in time-critical contexts, from large cohort studies to individualized medicine.

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Hugo, Marie, Audrey Pierreisnard, Nadia Mehsen-Cetre, Henri Gin, Thierry Schaeverbeke, and Vincent Rigalleau. "Action of tocilizumab on energy expenditure in rheumatoid arthritis: A prospective study using calorimetry and actimetry." Joint Bone Spine 84, no. 6 (December 2017): 751–52. http://dx.doi.org/10.1016/j.jbspin.2016.11.011.

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Lee, Ellen E., Ameya Amritwar, L. Elliot Hong, Iqra Mohyuddin, Timothy Brown, and Teodor T. Postolache. "Daily and Seasonal Variation in Light Exposure among the Old Order Amish." International Journal of Environmental Research and Public Health 17, no. 12 (June 21, 2020): 4460. http://dx.doi.org/10.3390/ijerph17124460.

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Exposure to artificial bright light in the late evening and early night, common in modern society, triggers phase delay of circadian rhythms, contributing to delayed sleep phase syndrome and seasonal affective disorder. Studying a unique population like the Old Order Amish (OOA), whose lifestyles resemble pre-industrial societies, may increase understanding of light’s relationship with health. Thirty-three participants (aged 25–74, mean age 53.5; without physical or psychiatric illnesses) from an OOA community in Lancaster, PA, were assessed with wrist-worn actimeters/light loggers for at least 2 consecutive days during winter/spring (15 January–16 April) and spring/summer (14 May–10 September). Daily activity, sleep–wake cycles, and their relationship with light exposure were analyzed. Overall activity levels and light exposure increased with longer photoperiod length. While seasonal variations in the amount and spectral content of light exposure were equivalent to those reported previously for non-Amish groups, the OOA experienced a substantially (~10-fold) higher amplitude of diurnal variation in light exposure (darker nights and brighter days) throughout the year than reported for the general population. This pattern may be contributing to lower rates of SAD, short sleep, delayed sleep phase, eveningness, and metabolic dysregulation, previously reported among the OOA population.

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Borel, A. L., J. L. Pepin, L. Nasse, J. P. Baguet, S. Netter, and P. Y. Benhamou. "Short Sleep Duration Measured by Wrist Actimetry Is Associated With Deteriorated Glycemic Control in Type 1 Diabetes." Diabetes Care 36, no. 10 (May 28, 2013): 2902–8. http://dx.doi.org/10.2337/dc12-2038.

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Matuzaki, L., C. R. C. Moreno, R. S. Silva, S. Tufik, and L. R. A. Bittencourt. "009 SLEEP-WAKE CYCLE PATTERNS EVALUATED BY ACTIMETRY IN AN ADULT SAMPLE OF SAO PAULO CITY POPULATION." Sleep Medicine 10 (December 2009): S3. http://dx.doi.org/10.1016/s1389-9457(09)70011-5.

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44

Mishra, Asit, Marcel Loomans, and Risto Kosonen. "Actimetry for Estimating Occupant Activity Levels in Buildings: A Step Toward Optimal and Energy-Efficient Indoor Conditioning." IEEE Consumer Electronics Magazine 8, no. 1 (January 2019): 67–71. http://dx.doi.org/10.1109/mce.2018.2867983.

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45

Brink, M., P. Lercher, A. Eisenmann, and Ch Schierz. "Influence of slope of rise and event order of aircraft noise events on high resolution actimetry parameters." Somnologie - Schlafforschung und Schlafmedizin 12, no. 2 (June 2008): 118–28. http://dx.doi.org/10.1007/s11818-008-0345-9.

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46

Palot, A., D. Piperno, L. Lerousseau, F. Leguillou, G. Jebrak, A. Chaouat, G. Giannoli, D. Perrin, and E. Leutenegger. "Observance de la déambulation sous oxygénothérapie en vie réelle des patients en insuffisance respiratoire chronique : données à 1 an de l’étude ACTIMETRE." Revue des Maladies Respiratoires 35 (January 2018): A43. http://dx.doi.org/10.1016/j.rmr.2017.10.090.

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47

Kędzierska, Ewa, Lila Dąbkowska, Paweł Obierzyński, Magdalena Polakowska, Ewa Poleszak, Piotr Wlaź, Katarzyna Szewczyk, and Jolanta Kotlińska. "Synergistic Action of Sodium Selenite with some Antidepressants and Diazepam in Mice." Pharmaceutics 10, no. 4 (December 12, 2018): 270. http://dx.doi.org/10.3390/pharmaceutics10040270.

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Background: The antidepressant and anxiolytic effects of selenium (Se) have been proven in many studies. This work was aimed at confirming these activities of its inorganic form—sodium selenite—and examining the possible synergy of action with antidepressants and diazepam. Methods: The antidepressant- and anxiolytic-like activity of Se was assessed using forced swim tests (FSTs) and elevated plus-maze test (EPMs). Spontaneous locomotor activity was measured using photoresistor actimeters. The experiments were conducted on male Albino Swiss mice. Results: Sodium selenite (0.5 mg/kg) reduced the immobility time in the FSTs and extended time spent in the open arms of EPMs without affecting locomotor activity The combined administration of Se at an ineffective dose (0.25 mg/kg) together with imipramine (15 mg/kg), fluoxetine (5 mg/kg), tianeptine (10 mg/kg), but not with reboxetine (2.5 mg/kg), resulted in a reduction of immobility time in FSTs, and with a threshold dose of diazepam (0.25 mg/kg) led to the prolongation of time spent in the open arms of the EPM. Moreover, the antidepressant-like effect of Se (0.5 mg/kg) was significantly reduced by pretreatment with p-chlorophenylalanine (100 mg/kg). Conclusions: The results may indicate the participation of serotonergic transmission to antidepressant action of Se and GABA-ergic transmission to its anxiolytic effects.

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MIDDELKOOP, HUUB A. M., ELLEN M. DAM, DINI A. SMILDE-VAN DEN DOEL, and GERT DIJK. "45-Hour continuous quintuple-site actimetry: Relations between trunk and limb movements and effects of circadian sleep-wake rhythmicity." Psychophysiology 34, no. 2 (March 1997): 199–203. http://dx.doi.org/10.1111/j.1469-8986.1997.tb02132.x.

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Ortiz-Tudela, Elisabet, Antonio Martinez-Nicolas, Manuel Campos, María Ángeles Rol, and Juan Antonio Madrid. "A New Integrated Variable Based on Thermometry, Actimetry and Body Position (TAP) to Evaluate Circadian System Status in Humans." PLoS Computational Biology 6, no. 11 (November 11, 2010): e1000996. http://dx.doi.org/10.1371/journal.pcbi.1000996.

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Mann, T. M., K. E. Williams, P. C. Pearce, and E. A. M. Scott. "A novel method for activity monitoring in small non-human primates." Laboratory Animals 39, no. 2 (April 1, 2005): 169–77. http://dx.doi.org/10.1258/0023677053739783.

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Patterns of spontaneous activity are valuable reflections of well-being in animals and humans and, because of this, investigations have frequently incorporated some form of activity monitoring into their studies. It is widely believed that activity monitoring, alongside assessments of general behaviour, should be included in initial CNS safety pharmacology screening. As the number of marmoset studies having actimetry as their focus, or as an adjunct, is increasing, we wished to evaluate an alternative approach to those commonly used. The method is based on miniaturized accelerometer technologies, currently used for human activity monitoring. Actiwatch®-Minis were used to monitor the activity of two groups of differently housed marmosets for 14 consecutive days. Group A consisted of four mixed-sex pairs of animals and group B comprised eight group-housed males. Activity profiles were generated for weekday and weekend periods. The devices captured quantifiable data which showed differences in total activity between the two differently housed groups and revealed intragroup variations in the temporal spread of activity between weekdays and weekends. The Actiwatch®-Mini has been shown to generate retrospective, data-logged activity counts recorded from multiple animals in a single arena by means of non-invasive monitoring.

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