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Дисертації з теми "Acidic patch"

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1

Martin, Franck. "Structural and functional studies of chromatin remodeling complex mamalian SWI / SNF." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ044.

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Анотація:
La chromatine est une structure dynamique régulée par différents mécanismes épigénétiques parmi lesquels le remodelage de la chromatine dépendant de l’ATP comme le SWI/SNF. Leur importance est telle que les mutations des protéines de remodelage de la chromatine sont fortement associées à plusieurs maladies dont le cancer. Par exemple les protéines BCL7, qui sont de nouvelles sous unité centrales récemment identifié du complexe SWI/SNF des mammifère, sont associées à différents types de cancers comme dans le Diffuse Large B-cell Lymphoma (DLBCL). Les informations sur les protéines BCL7 sont à c
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2

Malieieva, Galyna. "Les acides gynkgolique et niflumique sont les nouveaux modulateurs de récepteur à la glycine." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0030/document.

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Анотація:
Le récepteur à la glycine est un récepteur neuronal qui appartient à la famille des canaux ligand-dépendants «cys-loop». Avec le récepteur ionotrope GABA ils fournissent la neurotransmission inhibitrice rapide dans le SNC des vertébrés grâce à leur perméabilité sélective au Cl-. Les récepteurs à la glycine participent à différents processus physiologiques comprenant le contrôle de l'activité motrice, la respiration, la sensation de douleur inflammatoire, la perception des stimuli visuels et auditifs. Le développement de modulateurs efficaces des récepteurs à la glycine permettra un contrôle pr
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3

Peverini, Laurie. "Conception et application de nouveaux outils photochimiques pour l’étude des récepteurs canaux P2X." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF061/document.

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Анотація:
Les récepteurs P2X (P2XR), activés par l’ATP, sont impliqués dans des rôles physiopathologiques. Leur fonctionnement est associé à différents états conformationnels. Le projet de thèse a mené à associer la synthèse organique et l’application de molécules photo-activables avec des techniques d’électrophysiologie patch-clamp, pour décortiquer les mouvements moléculaires de ces récepteurs et effectuer des relations structure-fonction, via trois stratégies : - La synthèse et application d’agrafes photo-isomérisables qui permet le photo-contrôle des P2XR et l’étude de mouvements - La synthèse et ca
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4

Chatelier, Aurélien. "Modulation des performances cardio-respiratoires du bar européen (Dicentrarchus labrax) par l'apport d'acides gras alimentaires : une étude intégrée des effets cardiaques in vivo au courant calcique de type L des myocytes ventriculaires." La Rochelle, 2005. http://www.theses.fr/2005LAROS148.

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Анотація:
La qualité du régime alimentaire, et en particulier sa composition en acides gras, est un facteur environnemental émergeant en tant que source de diversité physiologique. En effet, de nombreux travaux montrent que la composition en acides gras de l'alimentation influence les performances cardiaques et métaboliques des organismes. Le cœur joue un rôle central dans l'adaptation des poissons à leur environnement en assurant et en régulant, les flux internes d'énergie et de matière. Dans le contexte de l'adaptation environnementale des individus et de l'évolution des espèces, la compréhension des
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5

Mistry, Dineshkumar. "The vertebrate neuronal gamma-aminobutyric acid (GABAa) receptor and its modulation : a patch clamp study." Thesis, University of St Andrews, 1988. http://hdl.handle.net/10023/14452.

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Анотація:
Pressure application of gamma-aminobutyric acid (GABA) to mouse spinal and rat DBG neurones maintained in culture evoked transient membrane currents. Using the whole-cell patch clamp technique, these currents were shown to primarily involve the flow of Cl-. The GABA-evoked whole-cell currents in both types of neurones were reversibly suppressed by the GABAA antagonist bicuculline. The barbiturate phenobarbitone reversibly potentiated GABA-evoked whole-cell currents in mouse spinal neurones. Attempts to look at the unitary currents activated by GABA in outside-out patches, revealed spontaneous
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6

Syme, C. A. "Patch-clamp studies on endothelial cell and chromaffin cell K'+ channels : effects of shear stress, membrane stretch and fatty acids." Thesis, University of Strathclyde, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298575.

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7

Tatu, Rigwed R. "Development and Characterization of aPoly (l-lactic acid)/ Poly (e-caprolactone) Self-Expanding Patch forFetoscopic Repair of Myelomeningocele." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535635832679162.

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8

Zieren, Jürgen. "Hernienreparationen mit Netzprothesen klinische und experimentelle Untersuchungen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13702.

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In einer prospektiv-randomisierten klinischen Studie zur Leistenhernienreparation wurde die konventionelle Shouldice Operation mit den spannungsfreien Verfahren durch Netzimplantation in endoskopischer (transabdominelle praeperitoneale Netzplastik, TAPP) und offener Technik (Plug und Patch Reparation; PP) verglichen. Bezogen auf das Hauptzielkriterium postoperative Schmerzen ergaben beide spannungsfreie Verfahren (TAPP, PP) signifikant guenstigere Ergebnisse als die Shouldice Operation. Bei vergleichbarer Komplikationsrate war die Dauer postoperativer Einschraenkungen bei den spannungsfreien V
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9

Facchin, Andrea. "New path for thermochemical-biological conversion with a power-to-material approach." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23117/.

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Анотація:
I sistemi termochimico-biologici si basano su due proprietà: la capacità dei processi termochimici di dissociare le macromolecole della biomassa producendo composti a basso peso molecolare, e l’abilità dei batteri di convertire substrati anche complessi in sostanze chimiche di valore. Questa tesi ha sviluppato un nuovo approccio metodologico per approfondire la possibilità di un accoppiamento diretto tra pirolisi e digestione anaerobica, allo scopo di produrre acidi grassi volatili (VFA), sinergicamente con l’utilizzo di idrogeno come fonte rinnovabile per aumentare il valore del prodotto fina
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10

Kacem, Hanana Houda. "Établissement de primocultures de cellules cardiaques de palourdes Ruditapes decussatus : étude des courants ioniques et des MAP Kinases après exposition des cellules à des xénoobiotiques." Brest, 2011. http://www.theses.fr/2011BRES2011.

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Анотація:
La nécessité d’évaluer l’impact des xénobiotiques du milieu aquatique sur les organismes, justifie la mise en place de nouveaux bioessais et de biomarqueurs afin d’identifier les risques sanitaires et mieux les prévenir. L’utilisation de méthodes alternatives à l’expérimentation animale, telles que les cultures de cellules, est préconisée en toxicologie. C’est dans ce contexte que des cultures primaires de cellules cardiaques de palourde Ruditapes decussatus ont été mises en place afin d’évaluer les effets de trois types de polluants du milieu marin un biocide, une phycotoxine et un herbicide.
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11

Mazza, Alessia Zecca. "The calcium path across the plasma membrane Ca2+-ATPhase : a study by single amino acid mutations /." Zürich, 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13235.

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12

Ozhathil, Lijo Cherian. "A structural and functional insight into TMEM16B, a calcium-activated chloride channel." Doctoral thesis, SISSA, 2014. http://hdl.handle.net/20.500.11767/3921.

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Анотація:
TMEM16B, also known as anoctamin 2 has been recently identified as a calcium-activated chloride channel. It is expressed at the synaptic terminals of photoreceptors, in hippocampal cells, in the cilia of olfactory sensory neurons and in the microvilli of vomeronasal sensory neurons. TMEM16B, as its most known cousin TMEM16A, is activated both by calcium and voltage. When this thesis was started there was no available data correlating the gating function and protein structure in TMEM16B. In our first manuscript, we show a coupling between calcium and voltage in TMEM16B activation. Primary seq
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13

Breeze, Liam J. "Cav1.2 pore structure using the substituted-cysteine accessibility method /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.

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Анотація:
Thesis (Ph.D. in Neuroscience) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 108-118). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
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14

Manzini, Ivan. "Diversity of transduction mechanisms in receptor neurons of the main olfactory epithelium in Xenopus laevis tadpoles." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975110926.

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15

Biet, Michaël. "Rôle et implication du courant sodique cardiaque dans la genèse de phénomènes arythmogéniques en conditions physiopathologiques." Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6054.

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Анотація:
Le potentiel d’action cardiaque est un phénomène électrique finement régulé par des modifications du voltage membranaire engendré par l’ouverture de différents canaux ioniques (sodium, calcium, chlore et potassium) présents à la surface des cardiomyocytes. Les transferts d’ions, de part et d’autre de la membrane via ces canaux, génèrent des courants pouvant être mesurés par la technique de patch clamp. L’activité électrique cardiaque est donc la résultante d’un équilibre de différents flux d’ions qui peut également être modulé par les systèmes sympathique et parasympathique afin de permettre l
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16

Frenal, Karine. "Caractérisation structurale et fonctionnelle de TgDRE : une enzyme de réparation de l' ADN du parasite Toxoplasma gondii." Paris 6, 2006. http://www.theses.fr/2006PA066031.

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17

Coussin, Frédéric. "Identification et rôle des récepteurs-canaux à la ryanodine dans la signalisation calcique intracellulaire des myocytes vasculaires : approche par microscopie confocale et oligonucléotides antisens." Bordeaux 2, 2000. http://www.theses.fr/2000BOR28801.

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18

Rudolph, Tim Christoph [Verfasser], Lothar [Akademischer Betreuer] Mörl, Waltraud [Akademischer Betreuer] Kahle, and Gerald [Akademischer Betreuer] Warnecke. "Model-based stochastic optimization of palm oil deodorization via Short-Path-Distillation towards 3-MCPD fatty acid ester formation and major oil quality parameters / Tim Christoph Rudolph ; Lothar Mörl, Waltraud Kahle, Gerald Warnecke." Magdeburg : Universitätsbibliothek, 2016. http://d-nb.info/1125507993/34.

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19

Rudolph, Tim Christoph Verfasser], Lothar [Akademischer Betreuer] [Mörl, Waltraud [Akademischer Betreuer] Kahle, and Gerald [Akademischer Betreuer] Warnecke. "Model-based stochastic optimization of palm oil deodorization via Short-Path-Distillation towards 3-MCPD fatty acid ester formation and major oil quality parameters / Tim Christoph Rudolph ; Lothar Mörl, Waltraud Kahle, Gerald Warnecke." Magdeburg : Universitätsbibliothek, 2016. http://d-nb.info/1125507993/34.

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20

Ito, Vanessa Mayumi. "Concentração de tocoferois e fitoesterois a partir do destilado desodorizado de oleos vegetais atraves do processo de destilação molecular." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267393.

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Анотація:
Orientadores: Maria Regina Wolf Maciel, Cesar Benedito Batistella<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica<br>Made available in DSpace on 2018-08-09T17:03:30Z (GMT). No. of bitstreams: 1 Ito_VanessaMayumi_D.pdf: 2213403 bytes, checksum: a16f218d14a3434ec925c550641af635 (MD5) Previous issue date: 2007<br>Resumo: Resumo: Os tocoferóis e fitoesteróis são componentes minoritários presentes em plantas e óleos vegetais. Os tocoferóis apresentam atividades vitamínicas e propriedades antioxidantes. A vitamina E é composta por 4 tocoferóis (a, b, g e d)
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21

Bertram, Janet. "Effects of cow urine and its constituents on soil microbial populations and nitrous oxide emissions." Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1334.

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Анотація:
New Zealand’s 5.3 million strong dairy herd returns approximately 106 million litres of urine to pasture soils daily. The urea in that urine is rapidly hydrolysed to ammonium (NH₄⁺), which is then nitrified, with denitrification of nitrate (NO₃⁻) ensuing. Nitrous oxide (N₂O), a potent greenhouse gas (GHG), is produced via nitrification and denitrification, which are enzyme-catalysed processes mediated by soil microbes. Thus microbes are linked intrinsically to urine patch chemistry. However, few previous studies have investigated microbial dynamics in urine patches. Therefore the objective of
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22

Urio, Ricardo de Prá. "Cromatografia a líquido por injeção sequencial para a determinação de herbicidas triazínicos e metabólitos da atrazina explorando o uso de cela de longo caminho óptico e monitoramento on-line em estudos de adsorção." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-31082011-143740/.

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Анотація:
Estudou-se o emprego da Cromatografia a Líquido por Injeção Seqüencial (SIC) explorando o uso de uma cela de longo caminho óptico com guia de onda (LCW) de 100 cm para a melhora dos limites de detecção (LOD) e quantificação (LOQ) na determinação de atrazina (ATR), propazina (PRO) e simazina (SIM). Para isto, utilizou-se uma fase móvel com composição de 44:56 (v v-1) metanol : tampão acetato de amônio 1,25 mM, pH 4,7, coluna monolítica e a detecção espectrofotométrica em 238 nm. Obtiveram-se valores de LOD e LOQ, respectivamente, de 1,76 e 5,86 &#181;g L-1 para ATR, 4,51 e 15 &#181;g L-1 para P
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23

Wong, Ee Nuan, and 黃奕鑾. "Gellan gum/Hyaluronic acid carrier Clioquinol or 5-fluorouracil as the treatment patch of oral cancer." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/65685177401355788013.

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24

Kang, Pei-Leun, and 康沛倫. "Hyaluronic Acid/Collagen/Mesenchymal Stem Cells Cardiomyocyte-like Cells Cardiac Patch on the Restoration of Injured Myocardium." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/55251440463832049067.

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博士<br>國立臺灣大學<br>醫學工程學研究所<br>102<br>As well known, cardiomyocytes and neural cells are un-proliferative cells in human. Especially, when the cardiomyocytes damaged, necrotized and loosed its function, the heart is difficult to recover to its original function. To date, in clinical practice, the remedy of this damaged heart is by heart transplantation or heart assist devices. Besides, by implanting regenerative cardiomyocytes into the defect area is now acquiring more attentions from many recent researchers. 5-azacytidine is used to differentiate the mesenchymal stem cells (MSCs) to cardiomyocyt
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25

Daniels, Bryan. "Modulation of ionotropic glutamate receptors in retinal neurons by the amino acid D-serine." 2011. http://hdl.handle.net/10222/13296.

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Анотація:
D-Serine is regarded as an obligatory co-agonist required for the activation of NMDA-type glutamate receptors (NMDARs). In the retina D-serine and a second NMDAR coagonist, glycine, are present at similar concentration and the cells that produce and release them are in close apposition. This arrangement allows for an abundant supply of coagonists and under certain conditions the NMDAR coagonist binding site could be saturated. There is also evidence suggesting that D-serine can act in an inhibitory manner at AMPA/kainate-type glutamate receptors (GluRs). Glutamate receptor activation can l
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26

Aromataris, Edoardo Claudio. "Pharmacology of the CIC-1 chloride channel." 2009. http://hdl.handle.net/2440/58973.

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Анотація:
Clinical studies reported side effects of muscular spasms and muscle stiffness following the administration of clofibrate, a drug once used to treat hyperlipidaemia in patients. Experiments with clofibrate and its analogues in animal models showed it produced these myotonic symptoms in muscle by reducing the chloride conductance of the muscle membrane. The effects of 2-(4-chlorophenoxy)propionic acid, an analogue of clofibric acid, was assessed on the rat ClC-1 channel (rClC-1). Racemic 2-(4-chlorophenoxy)propionic acid shifted the voltage dependence of rClC-1 activation to more depolarising p
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27

Yu, Ya-Hui, and 游雅惠. "Application of Flush Response to Niacin Skin Patch in Schizophrenia Research: Comparing Visual Rating with Infrared Thermography and Their Relations to Fatty Acids Levels in Blood." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/90272977649091262130.

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Анотація:
碩士<br>國立臺灣大學<br>流行病學與預防醫學研究所<br>99<br>Background: Attenuated niacin-induced flush response, a potential endophenotype for schizophrenia, has been postulated to involve a prostaglandin-related microvasodilation pathway where arachidonic acid or other fatty acids may play important roles. However, the correlations between the flush response and the implicated biochemical indexes remained incoherent, either because of different ways in giving niacin challenge test or in the evaluation of response. Alternatively measuring the raising temperature accompanying the niacin-induced flush might serve as
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28

Aromataris, Edoardo Claudio. "Pharmacology of the CIC-1 chloride channel." Thesis, 2009. http://hdl.handle.net/2440/58973.

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Анотація:
Clinical studies reported side effects of muscular spasms and muscle stiffness following the administration of clofibrate, a drug once used to treat hyperlipidaemia in patients. Experiments with clofibrate and its analogues in animal models showed it produced these myotonic symptoms in muscle by reducing the chloride conductance of the muscle membrane. The effects of 2-(4-chlorophenoxy)propionic acid, an analogue of clofibric acid, was assessed on the rat ClC-1 channel (rClC-1). Racemic 2-(4-chlorophenoxy)propionic acid shifted the voltage dependence of rClC-1 activation to more depolarising
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29

Chamberlain, S. E., I. M. Gonzàlez-Gonzàlez, K. A. Wilkinson, et al. "SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity." 2012. http://hdl.handle.net/10454/5911.

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Анотація:
No<br>Phosphorylation or SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. However, it is unknown whether phosphorylation and SUMOylation of GluK2 are important for activity-dependent KAR synaptic plasticity. We found that protein kinase C-mediated phosphorylation of GluK2 at serine 868 promotes GluK2 SUMOylation at lysine 886 and that both of these events are necessary for the internalization of GluK2-containing KARs that occurs during long-term depression of KAR-mediated synaptic transmission at rat hippocampal mossy
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