Дисертації з теми "Acidic oligopeptides"
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Bonnel, Clément. "Oligopeptides construits autour du γ-aminoacide ATC : synthèses, analyses structurales et évaluation biologique". Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT201.
Повний текст джерелаThis manuscript describes the synthesis, the structural study and the biological evaluation of abiotic oligopeptides incorporating the heterocyclic gamma-amino acid ATC (4-Aminomethyl-1,3-Thiazole-5 Carboxylic acid). This original block is built around a thiazole ring and displays two lateral chains. Previous work in our laboratory highlighted that the presence of the thiazole ring between the positions alpha and beta implied that zeta angle was blocked around 0°, thus structuring poly-(S)-ATCs homo-oligomers in a right-handed 9-helix foldamer. First, development of a simple, flexible and enantioselective synthesis on a few grams scale has allowed to get access of a highly diverse ATC library from commercial alpha-amino acids. Introduction of the chemical diversity occurs via two key steps implying a cross-Claisen condensation and a Hantzsch cyclization. Then identification of NMR and FT-IR structural markers of ATC-containing oligomers was used to characterize the folding propensity of hybrid α:ATC oligomers. We demonstrated that 1:1 (L)-alpha:(S)-ATC heterochiral oligomers are structured in solution in a new ribbon-like shape stabilized by a bidentate intramolecular hydrogen bond network forming 9- and 12-membered pseudorings. The distribution of lateral chains along the main skeleton shows a high analogy with alpha-helix thus constituting a major advantage for potential medicinal applications. The last part of this work has focused on the design of amphipathic ATC-containing pseudo-peptides as antimicrobial agents
Sawhney, Ashish. "Synthesis and mass spectrometry studies of oligopeptides." Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/831.
Повний текст джерелаKapota, Catherine. "Interactions du cation sodium avec des molécules d'intérêt biologique : acides aminés et oligopeptides." Phd thesis, Ecole Polytechnique X, 2005. http://pastel.archives-ouvertes.fr/pastel-00001365.
Повний текст джерелаShen, Jialin. "The variation of the gas phase acidity of a cysteine residue in oligopeptides." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/791.
Повний текст джерелаBreitenkamp, Rebecca Boudreaux. "Oligopeptide-functionalized Graft Copolymers: Synthesis and Applications in Nucleic Acid Delivery." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/open_access_dissertations/5/.
Повний текст джерелаAkamatsu, Miki. "Quantitative Analysis of Hydrophobicity of Oligopeptides Using Physicochemical Amino Acid Side Chain Parameters and Submolecular Structural Descriptors." Kyoto University, 1990. http://hdl.handle.net/2433/78240.
Повний текст джерелаDale, Ryan K. "Temperature and the biological response a multivariate statistical analysis of the variation in genomic organization, oligopeptide frequencies, and environmental temperature /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 235 p, 2009. http://proquest.umi.com/pqdweb?did=1654488371&sid=7&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Повний текст джерелаBarbot, Laurence. "Etude de l'expression intestinale de transporteurs d'acides aminés et d'oligopeptides au cours de la cryptosporidiose expérimentale chez le raton non sevré." Paris 5, 2002. http://www.theses.fr/2002PA05P617.
Повний текст джерелаCrytosporidium parvum is now recognized as being a major cause of diarrheal disease leading to malnutrition and growth retardation in young children. In order to assess the mechanism of C. Parvum-induced malnutrution, we investigated the intestinal expression of animo acid (EAAT3 and NBAT) and oligopeptides (PEPT1) transporters in an acute model of cryptosporidiosis in suckling rat aged from 4 to 50 days. We shown that parasite development induces a down- and up-regulation of PEPT1 and EAAT3 expression respectively along the entire small intestine at the peak of infection. Both transcriptional and post-translational mechanisms are involved in response to parasite implantation, hypophagia and mucosal immune response. .
Marini, Joseph Thomas. "Development and implementation of a FT-ICR mass spectrometer for the investigation of ion conformations of peptide sequence isomers containing basic amino acid residues by gas-phase hydrogen/deuterium exchange." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/115.
Повний текст джерелаAwussi, Ahoefa Ablavi. "Caractérisation génétique et biochimique du système protéolytique de Streptococcus thermophilus : étude de la variabilité des systèmes de transport d’oligopeptides ; caractérisation des phénomènes d’ancrage, de maturation et de libération de la protéase PrtS ; production de peptides bioactifs à partir de caséines bovines." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0099/document.
Повний текст джерелаWe are interested in the production of bioactive peptides in fermented milk by the lactic acid bacterium Streptococcus thermophilus. For this, it requires that the bacterium internalize them as few as possible during its growth. Therefore, it was important to characterize the proteolytic system of S. thermophilus. First, phylogenetic relationships linking 30 S. thermophilus strains have been searched by MLST. Secondly, an ABC-type transport system which seems to be functional was identified in the LMD-9 strain and named OTS. A study of the variability of Ami and OTS transport systems of the 30 strains of S. thermophilus was performed. Finally, the hydrolysis of caseins by proteinase PrtS of S. thermophilus was studied. This proteinase usually anchored to the wall of the bacterium was also found in a free form in strain 4F44. The protein sequence of PrtS4F44, different from the one of PrtS in the LMD-9 strain (PrtSLMD-9), is not the cause of the partial release of PrtS4F44. Sortase A, the actor of the anchoring of PrtS to the wall of the bacteria, presents different alleles between the strain 4F44 (srtA4F44) and the LMD-9 strain (srtALMD-9). Indeed, PrtSLMD-9 is released when srtALMD-9 is replaced by srtA4F44 in the strain LMD-9 showing that SrtA4F44 is deficient, causing consequently a default of PrtS4F44 anchoring and its partial release into the extracellular medium. Additionally, hydrolysis of bovine caseinates was performed using the free form PrtS4F44 and allowed the production of bioactive peptides that can be used for the functionalization of fermented dairy products
Anand, Banmeet Singh Mitra Ashim K. "Design of prodrugs of acyclovir for ocular, oral, and genital herpes virus infections targeting the oligopeptide and amino acid transporter on the cornea and intestine for improved bioavailability, safety and therapeutic activity /." Diss., UMK access, 2005.
Знайти повний текст джерела"A dissertation in pharmaceutical sciences and chemistry." Advisor: Ashim K. Mitra. Typescript. Vita. Description based on contents viewed Nov. 21, 2007; title from "catalog record" of the print edition. Includes bibliographical references (leaves 238-258). Online version of the print edition.
Khan, Md Arif. "NANOHARVESTING AND DELIVERY OF BIOACTIVE MATERIALS USING ENGINEERED SILICA NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/cme_etds/110.
Повний текст джерелаEl, Aribi Houssain. "Examination of fragmentations of protonated and metallated amino acids, oligopeptides, and their building blocks using triple quadrupole mass spectrometry /." 2003. http://wwwlib.umi.com/cr/yorku/fullcit?pNQ99165.
Повний текст джерелаTypescript. Includes bibliographical references. Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pNQ99165
Angkawijaya, Artik Elisa, and 翁玉鑽. "FIRST ROW TRANSITION METAL IONS, PHENOLIC ACIDS AND GLYCINE OLIGOPEPTIDES: STUDY OF COMPLEX FORMATION AND LIGAND STRUCTURAL INFLUENCE ON ITS SOLUTION EQUILIBRIA." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/86468947426179555522.
Повний текст джерела國立臺灣科技大學
化學工程系
101
The equilibrium constants for metal ions (Fe3+, Cr3+, Cu2+, Ni2+, Co2+) with ligands (glycine, glycylglycine, glycylglycyglycine, L-norvaline, ferulic acid and gallic acid) were reported in this work. The protonation constants of these ligands along with the formation of metal-ligand complex in binary and ternary systems were studied by using pH-potentiometric titration in aqueous solution at 298.15K and an ionic strength 0.15 mol‧dm-3 of NaNO3. The complexation model for each system was refined by software program “HYPERQUAD 2008” from potentiometric titration data. Moreover, Gibbs free energy of reaction (?愉G) that obtained from Gaussian modeling program were used to verify the contributing binding site of the ligands and to predict the structure of the one metal and one ligand complexes. The phenomenon that occurred in each system was discussed. In terms of metal ion, the trend of stability constant decreases in the following order Fe3+ > Cr3+ > Cu2+ > Ni2+ > Co2+, which is affected by its electrical charge and following Irving-William rule for divalent metal ion. In terms of the ligand, the system with less bulky structure (glycine) and more negatively charged ligand (gallic acid) formed more stable complex than the other ligands. While for system with gycine oligopeptide, nitrogen in peptide backbone enhanced the complex stability while it existed in deprotonated form. In ternary system that contains gallic acid, the stability constant of the complexes are more stable than the systems with ferulic acid. The stability of mixed ligand complexes was quantitatively compared with corresponding binary complexes in term of ∆logK and logX.
Zhang, Wentao. "Thermodynamic characterizations of coulombic end effects and coupled folding effects on binding of cationic oligopeptides in nucleic acids Two-domain analysis of preferential solute-protein interactions /." 1996. http://catalog.hathitrust.org/api/volumes/oclc/37034182.html.
Повний текст джерелаSengupta, Anindita. "X-Ray Crystallographic Studies Of Designed Peptides And Protected Omega Amino Acids : Structure, Conformation, Aggregation And Aromatic Interactions." Thesis, 2007. http://hdl.handle.net/2005/504.
Повний текст джерелаKarri, Phaneendrasai. "Mechanistic And Synthetic Investigations On Carboxylic Anhydrides And Their Analogs." Thesis, 2008. http://hdl.handle.net/2005/1058.
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