Дисертації з теми "Achilles tendinopathy (AT)"
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Costa, Matthew. "Achilles tendinopathy and rupture." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426770.
Повний текст джерелаGrävare, Silbernagel Karin. "Achilles tendinopathy : evaluation and treatment /." Göteborg : Department of Orthopaedics, Institute of Clinical Sciences, The Sahlgrenska Academy at Göteborg University, 2006. http://hdl.handle.net/2077/504.
Повний текст джерелаÅström, Mats. "On the nature and etiology of chronic achilles tendinopathy." Lund : Dept. of Orthopaedics, Malmö University Hospital, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39705581.html.
Повний текст джерелаShalabi, Adel. "Magnetic resonance imaging in chronic achilles tendinopathy /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-811-4/.
Повний текст джерелаO'Neill, Seth. "A biomechanical approach to Achilles tendinopathy management." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40134.
Повний текст джерелаCrouzier, Marion. "Muscle coordination and musculoskeletal disorders : investigation of Achilles tendinopathy." Thesis, Nantes, 2020. http://www.theses.fr/2020NANT2013.
Повний текст джерелаThe Achilles tendon is made of three subtendons that each arises from a different head of the triceps surae: gastrocnemius medialis, gastrocnemius lateralis and soleus. Non-optimal distribution of load within Achilles tendon would contribute to the development of Achilles tendinopathy. Moreover, there is evidence that the distribution of load or strain within the Achilles tendon is partly determined by the distribution of force among the heads of the triceps surae. The overall aim of this thesis was to provide a deeper understanding of the role of muscle coordination (i.e. the distribution of force among muscles) on the development of Achilles tendinopathy. Individual muscle forces were estimated from muscle activation, volume and architecture. Results showed that (i) the distribution of activation among triceps surae is robust between days, and varies greatly between individuals; (ii) there is a significant positive correlation between the distribution of physiological cross-sectional area and the distribution of activation among gastrocnemii; (iii) muscle coordination among the triceps surae differs in people with Achilles tendinopathy compared with controls, with the gastrocnemius lateralis contributing significantly less to total triceps surae force in people with Achilles tendinopathy. Whether this altered strategy is a cause or a consequence of Achilles tendinopathy should be further explored
Saunders, Colleen Jayne. "Extracellular matrix gene sequence variant analyses and Achilles tendinopathy." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3199.
Повний текст джерелаIncludes bibliographical references)
The primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, COL5A2 and COL5A3) were selected based on their chromosomal location and/or the biological function of their encoded proteins within the extracellular matrix (ECM) of the tendon.
Hutchison, Anne-Marie. "The treatment and management of patients with a chronic mid body achilles tendinopathy." Thesis, Swansea University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678301.
Повний текст джерелаAzevedo, Liane. "Risk factors for Achilles tendinopathy in runners - an investigation of selected intrinsic, kinematic, kinetic and muscle activity factors that are associated with Achilles tendinopathy." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/2772.
Повний текст джерелаBjur, Dennis. "The human Achilles tendon : innervation and intratendinous production of nerve signal substances - of importance in understanding the processes of Achilles tendinosis." Doctoral thesis, Umeå universitet, Idrottsmedicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30284.
Повний текст джерелаMiranda, Ana Areias Marques. "O efeito dos exercícios excêntricos na tendinopatia do tendão de Aquiles em adultos saudáveis: revisão sistemática." Bachelor's thesis, [s.n.], 2016. http://hdl.handle.net/10284/5674.
Повний текст джерелаObjetivo: A presente revisão pretende compreender os efeitos da implementação de exercícios excêntricos na tendinopatia do tendão de aquiles independentemente da amostra utilizada. Metodologia: Pesquisa computorizada através das palavras-chaves elegidas, em bases de dados como Science Direct, EBSCO e Pubmed para selecionar artigos experimentais que colocassem em questão a eficiência dos exercícios excêntricos na tendinopatia do tendão de aquiles. Resultados: Foram incluídos 12 artigos, com um total de 465 indivíduos. Obtendo uma média de 8,8 na escala CASP. 3 artigos compararam o uso de exercícios excêntricos com o uso de uma ortótese noturna, outros 3 compararam com outras técnicas terapêuticas e os restantes aplicaram apenas exercícios excêntricos. Conclusão: Após a analise dos resultados é possível observar a eficácia dos exercícios excêntricos na tendinopatia do tendão de aquiles, no entanto, muitas vezes não são diferenças que corresponderiam ao expectável. A aplicação de ortóteses e aprendizagem do método não potencia o efeito positivo, contudo associado a outras técnicas terapêuticas (ultrassom e massagem transversal profunda) promove a sua eficácia.
Objective: The present revision pretends to comprehend the effects of the implementation of eccentric exercises in the Achilles tendinopathy regardless the sample used. Methodology: Computer research through elected keywords, in data bases such as Science Direct, EBSCO and Pubmed to select experimental articles that would question the effectiveness of eccentric exercises in the Achilles tendinopathy. Results: Twelve articles were selected, with a total of 465 individuals. Obtaining an average of 8,8 in the CASP scale. 3 articles compared the use of eccentric exercises with the use of a night orthosis, other 3 compared with other therapeutic techniques and the rest only applied eccentric exercises. Conclusion: After the analysis of the results it is possible to observe the effectiveness of the eccentric exercises of the Achilles tendinopathy, however, many times the differences would not correspond to the expectable. The application of orthosis and the learning method do not enhance the positive effect, however in association with other therapeutic techniques (ultrasound and deep transversal massage) promotes its effectiveness.
D'Costa, Lois Fatima. "Effectiveness of eccentric training in chronic Achilles tendinopathy : systematic critical review." Thesis, Manchester Metropolitan University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.647443.
Повний текст джерелаWillberg, Lotta. "Patellar and Achilles tendinopathy : sclerosing injections and ultrasound guided arthroscopic shaving." Doctoral thesis, Umeå universitet, Idrottsmedicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80194.
Повний текст джерелаRezvani, Sabah Nader. "Novel Preclinical Approaches to the Understanding and Treatment of Achilles Tendinopathy." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/103637.
Повний текст джерелаDoctor of Philosophy
Achilles tendinopathy is a chronic, overuse condition affecting the entire spectrum of society and a condition that increases the risk of tendon rupture. Therapies are limited, as anti-inflammatory drugs and surgical interventions show poor long-term outcomes. Drugs such as ibuprofen are commonly prescribed at the onset of injury to treat pain. Eccentric loading of the Achilles muscle-tendon unit is an effective physical therapy for treatment of human tendinopathy; however, the reasons driving the healing are not well understood. Characteristics of the disease include pain, increased tendon size, and disorganization of tendon fiber structure. Here, we present work investigating chemical, biological, and mechanical loading approaches to treating Achilles tendinopathy in a mouse model. Our mouse model of Achilles tendinopathy was used to investigate how ibuprofen (chemical) therapy might lead to a worsening of tendon by potentially interfering with the inflammation phase of tendon healing. We conclude that the use of ibuprofen for pain relief during inflammatory phases of tendinopathy has negative effects on the turnover of matrix produced in response to injury, affecting the transition to the next phase in the tendon healing response. We examined the potential of a recombinant human hyaluronidase, rHuPH20 (biologic, FDA approved for reducing HA accumulation in tumors) in a novel Achilles tendinopathy and retrocalcaneal bursitis injury model. The potential of rHuPH20 to effectively clear the proinflammatory, HA-rich matrix within the retrocalcaneal bursa (RCB) and tendon strongly supports the future refinement of injectable treatments as a potential to protect or regenerate tendon tissue by reducing inflammation and scarring in the presence of bursitis or other inducers of damage such as mechanical overuse. Finally, we developed a mouse model of hind limb muscle loading (mechanical) based on physical therapy exercises. This model led to an improvement in biomechanical measures compared to untreated animals. The model allows for investigation of the underlying mechanisms in which physical therapy promotes healing of Achilles tendon injuries. Overall, these findings enhance our understanding of the mechanisms of injury and treatment in Achilles tendinopathy injuries.
Dixon, Claire, Laureen Holloway, Teresa Lee, Nick Lo, Janice Meier, and Darlene Reid. "Pain-enduring Eccentric Exercise for the Treatment of Chronic Achilles Tendinopathy." Irving K. Barber Learning Centre, 2006. http://hdl.handle.net/2429/89.
Повний текст джерелаThis is a Systematic Review Presentation titled - "Pain-enduring Eccentric Exercise for the Treatment of Chronic Achilles Tendinopathy", created by Master of Physical Therapy Graduating Students, University of British Columbia - 2006, Presented on September 14-15, 2006 , Vancouver, BC, Canada
Spang, Christoph. "The plantaris tendon in relation to the Achilles tendon in midportion Achilles tendinopathy : studies on morphology, innervation and signalling substances." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103292.
Повний текст джерелаWeinert-Aplin, Robert. "Development of a foot and ankle musculoskeletal model : implications for achilles tendinopathy." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25519.
Повний текст джерелаJonsson, Per. "Eccentric training in the treatment of tendinopathy." Doctoral thesis, Umeå : Sports Medicine, Umeå university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25856.
Повний текст джерелаPayne, Catherine. "Clinical applications of shear wave elastography to achilles tendon imaging and the monitoring of a rehabilitation protocol for achilles tendinopathy." Thesis, University of Brighton, 2018. https://research.brighton.ac.uk/en/studentTheses/7e9deb5d-b2af-4f85-90b7-d7613811035c.
Повний текст джерелаUdeze-Jyambere, Chineye Princess. "The effect of loading frequency on tenocyte metabolism." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25982.
Повний текст джерелаBagge, Johan. "TNF-α and neurotrophins in Achilles tendinosis". Doctoral thesis, Umeå universitet, Anatomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-63660.
Повний текст джерелаHammar, Clausen Adrian. "Follow-up of Patients Treated with Sclerosing Therapy and/or Surgery for Achilles Tendinopathy." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-72993.
Повний текст джерелаAndersson, Gustav. "Influences of paratendinous innervation and non-neuronal substance P in tendinopathy : studies on human tendon tissue and an experimental model of Achilles tendinopathy." Doctoral thesis, Umeå universitet, Anatomi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35917.
Повний текст джерелаBecker, James N. M. 1979. "Towards an Understanding of Prolonged Pronation: Implications for Medial Tibial Stress Syndrome and Achilles Tendinopathy." Thesis, University of Oregon, 2013. http://hdl.handle.net/1794/13257.
Повний текст джерелаNetto, Cesar de Cesar. "Estudo histológico e biomecânico da tendinopatia induzida por injeções seriadas de colagenase: novo modelo experimental no tendão do calcâneo de coelho." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5140/tde-09082017-132050/.
Повний текст джерелаINTRODUCTION: This study aims to compare the biomechanical and histological findings of a new animal model of Achilles tendinopathy induced by serial low-dose injections of bacterial collagenase with the most commonly used high-dose single injection and to controls. The hypothesis of the study is that consecutive low-dose injections of collagenase would result in more progressive and long-lasting tendinopathic findings, reproducing better the disease in humans. METHODS: Forty-five (N=45) rabbits were randomly divided into three groups (A, B and Control). Animals in Group A (n=18) underwent three serial low-dose (0,1mg) injections of bacterial type I collagenase in both Achilles tendons, separated by a two-week interval. Animals in Group B (n=18) underwent bilateral single high dose injection (0,3mg) of the same enzyme. In the Control Group, animals (n=9) were injected bilaterally with three consecutive doses of saline solution, separated by a two-week interval. Following the last injection, the same number of rabbits from Groups A and B (n=6) were euthanized after 10 weeks (Subgroups A1 and B1), 12 weeks (Subgroups A2 and B2), and 16 weeks (Subgroups A3 and B3). Animals in the Control Group were all euthanized after 16 weeks. Histological findings, using the Bonar tendinopathy score, and biomechanical properties of the Achilles tendons were compared between the groups and inside each the group, in the different time-points of euthanasia. Findings at 16 weeks were considered primary outcomes. P-values < 0,05 were considered significant. RESULTS: After 16 weeks, the Bonar score was significantly increased for both Groups A (11,8±2,28) and B (5,6±2,51), when compared to controls (2±0,76). Group A has also differed from Group B (p < 0,001). Regarding biomechanical findings, groups differed in cross-sectional area of the Achilles tendon (p=0,003), Young\'s modulus (p=0,024), Yield stress (p=0,020) and ultimate tensile strength (p=0,022), with the worst results in animals from Group A. At 12 weeks, comparison between Groups A and B have shown significant differences for Bonar score (p=0,028) and Yield stress (p=0,013), again with worse results in Group A. Conversely, at 10 weeks, rabbits in Group B showed worse results when compared to Group A, with significant differences in the Bonar score (p=0,033), cross sectional area of the tendon (p=0,038), stiffness (p=0,048), Young\'s modulus (p=0,024), Yield tension (0,008), Yield stress (p=0,020), energy Yield (p=0,047), ultimate tension (p=0,004), ultimate stress (p=0,008) and yield strain energy density (p=0,015). The comparison of outcomes inside each group, in the different time-points of follow-up, demonstrated significant differences in the Bonar score for Group A (p=0,012) and Group B (p < 0,001). Regarding biomechanical properties, Group A showed no differences between the subgroups for any of the parameters evaluated. Subgroups in Group B differed for cross-sectional area of the tendon (p=0,011), Young\'s modulus (p=0,024), Yield stress (p=0,023), ultimate stress (p=0,031) and yield strain energy density (p=0,017), with worst results in the earliest follow-up (Subgroup B1). CONCLUSIONS: The animal model of Achilles tendinopathy induced by consecutive injections of collagenase showed worse histological and biomechanical properties after 16 weeks, demonstrating more progressive and long lasting tendinopathic findings, reproducing better the disease in humans. This novel experimental model can represent a better option to induce Achilles tendinopathy, allowing promising future research on the subject
Müller, Steffen. "Die belastungsspezifische neuromuskuläre Antwort bei Athleten mit Tendinopathie der Achilles- oder Patellarsehne : Analysen der funktionalen und therapeutischen Effekte eines sensomotorischen Trainings." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/1645/.
Повний текст джерелаTendinopathies of the achilles- or patellartendon are common overuse unjuries in sports including high numbers of repetitive stretch-shortening-cycles of the lower limb. Possible alterations of the neuromuscular response (NMR) to physical stress and functionally justified therapies with potential positive effects are currently unknown. The aim of the study was therefore the analysis of the neuromuscular response in situations with physical stress in athletes with tendinopathie of the achilles or patellartendon compared to symptom free athletes. In addition, possible functional and therapeutic effects of a sensorimotor training were studied in a prospective, randomized and controlled study. 51 athletes with unilateral tendinopathy (achilles-/patellartendon n = 35/16) and 33 healthy athletes were included to assess the stress related neuromuscular response (NMR). To clarify the effects of a sensorimotor training 26 athletes with tendinopathy were randomized to a control group (n = 14) and a therapy group with sensorimotor training (n = 12). After initial biomechanical measurements M1 (situations: running, active postural stability and maximum strength test) and the collection of subjective complaints (pain) an 8-week treatment phase followed with a final re-test M2 measure identical to M1. The sensorimotor training was arranged for the entire lower extremity, and was checked after an initial briefing on a regular basis. The assessment of the NMR was quantified by muscle activity (EMG). In addition, the kinetics (e.g. maximum force) was acquired in the stabilization and maximum strength test. A reduced NMR could be proven for athletes with tendinopathy with changed EMG time and amplitude measurements, a reduced active postural stabilization ability and reduced maximum strength (p <0.05). No relevant differences could be observed in comparing localization (achilles-/patellartendon) and side (leg with complains/healthy leg). The sensorimotor training showed an optimization of NMR (e.g. increased maximum strength) for patient with tendinopathy of the achilles- or patellartendon. The examination of the complaints showed reduced values in all pain scores after therapy. The treatment had therefore positive therapeutic effects compared to the control group. In summary, a systematically reduced NMR in running, stabilization and strength tests are evident for athletes with tendinopathy. The sensorimotor training can be considered as an efficient treatment with functional and therapeutic effects.
Della, Pasqua Alberto. "L'esercizio terapeutico nel trattamento della tendinopatia Achillea: revisione sistematica della letteratura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19320/.
Повний текст джерелаNell, Erica-Mari. "A pathway-based approach investigating DNA sequence variants to implicate the inflammatory pathway in the predisposition to Achilles tendinopathy." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10807.
Повний текст джерелаIncludes bibliographical references (leaves 159-179).
The aims of this dissertation were therefore (i) to follow a pathway-based approach investigating genes encoding proteins involved in the ECM degradation and apoptosis signalling cascade for associations with AT and (ii) to identify a polygenic risk model, comprised of several genetic markers within genes encoding proteins involved in the inflammatory pathway, to predict risk of AT.
Trogen, Josefin, and Clara Ringmar. "Är excentrisk träning den bästa behandlingen för akillestendinopati? : En systematisk litteraturstudie." Thesis, Uppsala universitet, Åsenlöf: Fysioterapi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443583.
Повний текст джерелаBackground: Achilles tendon issues is a common problem among athletes on all levels. The problem can cause pain and loss of function. Eccentric exercise is a somewhat gold standard and often used in the clinical setting although the level of evidence is limited and conflicting. Objective: Map the evidence of eccentric exercise as a treatment for achilles tendinopathy. Method: A systematic review. The search was conducted in the Pubmed database. The included studies were analyzed using the PEDro scale and the evidence was graded using the GRADEstud. Results: The literature search identified 7 studies that were included with a total of 448 participants. The studies received a moderate-high quality on PEDro. The level of evidence at 8-16 weeks was moderate (+++) and at 52 weeks very low (+). Eccentric exercise had a lower effect than heel lifts and acupuncture measured with VISA-A. Eccentric exercise had a similar effect on VISA-A as passive stretch and heavy slow resistance. At 52 weeks the effect of eccentric exercise was the same as prolotherapy injections and heavy slow resistance. Conclusion: Eccentric exercise might have an effect as treatment for achilles tendinopathy, but the effect is the same or lower than other treatment options measured with VISA-A and might depend on the natural healing process or the participation in a study. The level of evidence for eccentric exercise was graded at 8-16 and 52 weeks respectively, as moderate (+++) and very low (+). This is based on studies of moderate to high quality.
Backman, Ludvig. "Neuropeptide and catecholamine effects on tenocytes in tendinosis development : studies on two model systems with focus on proliferation and apoptosis." Doctoral thesis, Umeå universitet, Anatomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70193.
Повний текст джерелаBussin, Erin Rebecca. "Randomized controlled trial to evaluate the effects of topical diclofenac on the pain associated with chronic Achilles tendinopathy : a pilot study." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59289.
Повний текст джерелаMedicine, Faculty of
Graduate
Koszalinski, Alex Michael. "Trigger Point Dry Needling, Manual Therapy and Exercise versus Manual Therapy and Exercise for the Management of Achilles Tendinopathy| A Feasibility Study." Thesis, Nova Southeastern University, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13423731.
Повний текст джерелаBackground: The effect of trigger point dry needling (TDN) on myofascial trigger points (MTP) in Achilles tendinopathy are unknown. Objectives: To determine the feasibility of a large randomized controlled trial (RCT) to compare the effects of TDN to exercise in a patient population with Achilles tendinopathy. Methods: This single-factor, pretest-posttest control group design included 22 subjects between the ages of 24 and 65 years with Achilles tendinopathy. Subjects were randomly assigned to either a control group (MT+Ex) or experimental group (TDN+MT+Ex). Subjects in both groups completed 8 physical therapy treatment sessions over 4 weeks. The intervention for the TDN+MT+Ex group included TDN to MTPs in the gastrocnemius, soleus or tibialis posterior each session while the same soft tissue mobilization and exercise program was conducted in both groups. Results: Within group analysis was performed for each group at 4 week and 90 day follow up. Significant improvement (p < .05) was achieved for FAAM, NPRS, pain pressure threshold and strength in both groups at 4 weeks and 90 days. The GROC was significant for MT + Ex at 90 days. The MCID for the FAAM, GROC were surpassed in both groups at 4 weeks and 90 days. NPRS surpassed the MCID for the MT + Ex group at 4 weeks. Conclusion: A large RCT to investigate the effects of TDN on MTP in Achilles tendinopathy is feasible with modifications. Recommendations: Special considerations for data collection sites should be given to the health care system, insurance payor, and financial burden to subjects.
Abrahams, Yoonus. "The regulation of the COL5A1 gene via the 3' - UTR and its impact on Achilles Tendinopathy and other exercise-related phenotypes Yoonus Abrahams." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/4234.
Повний текст джерелаVieira, Cristiano Pedrozo 1986. "Efeito da nutrição terapêutica a base de Camellia sinensis (chá verde) e ração rica em glicina sobre a tendinite do tendão calcanear de rato = Effect of therapeutic nutrition on the basis of Camellia sinensis (green tea) and glycine-diet on the tendinitis of Achilles tendon of rats." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317356.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-26T15:25:06Z (GMT). No. of bitstreams: 1 Vieira_CristianoPedrozo_D.pdf: 3245048 bytes, checksum: 0556c35183a4503cef8427390d086781 (MD5) Previous issue date: 2015
Resumo: Nutrição terapêutica é a administração de alguns nutrientes, em doses maiores que as necessidades alimentares diárias que podem prevenir deficiências orgânicas e atuar como agentes farmacológicos. A glicina apresenta amplos efeitos benéficos em processos inflamatórios e tumorais. O Chá verde feito de folhas e brotos da planta Camellia sinensis, é a segunda bebida mais consumida em todo mundo. O interesse econômico e social tem ganhado espaço no mercado e atualmente seu consumo faz parte da rotina diária de muitas pessoas que utilizam essa bebida como uma finalidade terapêutica. O Chá verde possui propriedades antimutagênicas, antidiabéticos, antiinflamatórias, antioxidante, antimicrobial e hipocolesterolêmica. A tendinite é reconhecidamente um problema clínico que motiva a comunidade científica a buscar tratamentos que auxiliem no restabelecimento das propriedades funcionais dos tendões. O presente estudo investigou o efeito do chá verde e ou da ração rica em glicina após 7 e 21 dias da indução da tendinite com colagenase. Ensaios bioquímicos, moleculares, morfológicos e biomecânicos foram desenvolvidos. Além disso, tenócitos em cultura foram tratados com glicina após inflamação induzida por TNF-?. Nossos ensaios in vivo mostraram altas concentrações de hidroxiprolina e glicosaminoglicanos no grupo glicina e chá em 21 dias de tratamento. Nos ensaios biomecânicos os grupos chá verde e dieta de glicina em 21 dias suportaram maiores cargas biomecânicas antes da ruptura. Além disso, uma melhor organização das fibras de colágeno foi observada no grupo chá verde em 7 dias. Análises bioquímicas e moleculares da junção miotendínosa mostraram que a inflamação instalada na região osteotendinea pode provocar alterações significativas nesse local. Marcantes alterações foram notadas nas metaloproteínases (MMP) tais como MMP-2, MMP-8 e MMP-9 em animais com tendinite tratados ou não com chá verde e glicina. No estudo in vitro, tenócitos extraídos a partir de tendão de Aquiles foram tratados com TNF-?, seguindo ou não de tratamento com glicina em meio de cultura. Antes e após 24 horas da inflamação foi adicionado glicina. Tenócitos inflamados e tratados com glicina mostraram expressão de colágeno tipo I próxima aos grupos tratados com glicina previamente e depois da inflamação quando comparado ao grupo controle. Todos os grupos tratados com glicina mostraram menor expressão de MMP-2. A atividade da MMP-9 foi alta apenas no grupo tratado com glicina em 48 horas. A concentração de ácido urônico foi menor no grupo tratado com glicina 24 horas após a inflamação. No ensaio de migração celular, resultados em 24 horas de tratamento foram similares ao grupo controle. Em geral, tanto a glicina quanto o chá verde influenciam na síntese dos componentes do tendão, melhoram a organizaçao das fibras colagênicas, aumentam a resistência a cargas do tendão inflamado e consequentemente aceleram o processo de remodelamento após indução da tendinite. Além disso, o tratamento com glicina em cultura de tenócitos mostrou uma reorganização eficiente da matriz extracelular, corroborando com os resultados encontrados in vivo
Abstract: Therapeutic nutrition is the administration of some nutrients, in higher doses than those recommended for the daily food needs that can prevent dysfunctions and act as pharmacological agents. Glycine has large beneficial effects in inflammatory and tumor processes. Green tea made from leaves and buds of the Camellia sinensis plant, is the second most consumed beverage in the world. The economic and social interest has gained space in the market and currently its consumption is part of the daily routine of many people who use this drink as a therapeutic purpose. Green tea has antimutagenic, antidiabetic, anti-inflammatory, antioxidant, antimicrobial and hypocholesterolemic properties. Tendinitis is recognized as a clinical problem that motivates the scientific community to investigate treatments that help in restoring the functional properties of tendons. The present study investigated the effect of green tea and/or diet rich in glycine after 7 and 21 days of tendinitis collagenase-induced. Biochemical, molecular, morphological and biomechanical tests were developed. Furthermore, tenocytes in culture were treated with glycine after inflammation induced by TNF-?. Our tests in vivo showed high concentrations of hydroxyproline and glycosaminoglycans in glycine and green tea group in 21 days of treatment. In biomechanical assay, green tea and glycine diet groups in 21 days showed a high biomechanical loads bore before rupture. In addition, better organization of collagen fibers was observed in green tea group in 7 days. Biochemical and molecular analyzes of myotendinous junction showed that the inflammation installed in osteotendinious region can cause significant change in that region. Remarkable changes were noted in metalloproteinases (MMP) such as MMP-2, MMP-8 and MMP-9 in animals with tendinitis treated with or without glycine and green tea. In the in vitro study, tenocytes from Achilles tendon were treated with TNF-?, or not following treatment with glycine in the culture medium. Before and 24 hours after inflammation was added glycine. Tenocytes inflamed and treated with glycine showed expression of collagen type I close to the treated groups with glycine previously and after the inflammation when compared to the control group. All treated groups showed less glycine MMP-2 expression. The activity of MMP-9 was high only in the group treated with glycine for 48 hours. In the cell migration assay results in 24 hours of treatment were similar to the control group. In general, both glycine and green tea influenced the synthesis of the tendon components, improve the organization of the collagenous fibers, increase the load resistance of the inflamed tendon and consequently accelerate the remodeling process after inducing tendinitis. In addition, the treatment with glycine in tenocytes culture showed efficient reorganization of the extracellular matrix, confirming the results found in vivo
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
Grigg, Nicole Lorraine. "The acute adaptations of normal and pathological human Achilles tendons to eccentric and concentric exercise." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/47048/1/Nicole_Grigg_Thesis.pdf.
Повний текст джерелаAndere, Nathalie Ferrari Bechara. "Fatores clínicos e biomecânicos associados com a tendinopatia de calcâneo em corredores fundistas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-03052017-155858/.
Повний текст джерелаOBJECTIVE: To evaluate the clinical characteristics, vertical component of the ground reaction force and muscle function of plantar flexors and dorsiflexors of the ankle in runners with and without Achilles tendinopathy and in non-runners. METHODS: Seventy-two subjects (42 M: 30W, 37.3±9.9 years old) were divided into three groups: Achilles Tendinopathy Group (GTC, n=24), Runners Control Group (GCC, n=24) and Non-Runners Group (GNC, n=24), in which both ankles were evaluated in each group. The American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, parameters of ground reaction force, and isokinetic data were evaluated by means of force platforms and isokinetic dynamometer. RESULTS: The AOFAS ankle-hindfoot score was significantly lower in the GTC. The GRF was similar between the groups; however, the initial vertical impulse was higher in the GTC than in the GCC and GNC. There were no differences regarding the total impulse. The GTC presented lower total work in the 120º/s speed than the GCC. There were no differences regarding the other isokinetic variables between the GTC and GCC, only regarding the GNC. CONCLUSION: Runners with Achilles tendinopathy show higher impact at the moment of landing, lower muscle endurance of plantar flexors and higher clinical and functional damage. The association between higher impulse and lower endurance could be a predisposing and maintaining factor for Achilles tendon
Borella, Federica. "Tendon Neuroplastic Training, un nuovo approccio riabilitativo per la risoluzione del dolore e il ritorno allo sport nelle persone con tendinopatia achillea e patellare. Scoping review." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21904/.
Повний текст джерелаMarques, Anna Cristina de Farias. "Efeito do laser de baixa intensidade no colágeno tipo I e III na metaloproteinase de matriz em modelo experimental de tendinopatia induzida por colagenase em tendão calcâneo de ratas idosas." Universidade Nove de Julho, 2015. http://bibliotecatede.uninove.br/handle/tede/1796.
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This study investigates the effect of low-level laser therapy (LLLT) on collagen type I and III, matrix metalloproteinase (MMP), and vascular endothelial growth factor (VEGF) in experimentally induced tendinopathy in female aged rats. Tendinopathy was induced by collagenase peritendinous of the Achilles tendon. Forty-two Wistar rats (Norvegicus albinus) were used; groups consisted of 36 aged animals (18 months old; mean body weight, 517.7 ± 27.54 g) and 6 adult animals (12 weeks old; mean body weight, 266 ± 19.30 g). The animals were randomlydivided in three groups: control, aged tendinopathy, and aged tendinopathy LLLT; the aged groups were subdivided according to experimental periods: 7, 14, and 21 days. LLLT involved a gallium-arsenide-aluminum laser (Theralaser, DMC®) with active medium operating at wavelength 830 ± 10 nm, 50 mW power, 0.028 cm2 laser beam, 107 J/cm2 energy density, 1.7 w/cm2 power density, and 6 J of energy, with a frequency of 3 times per week, until euthanasia. VEGF, MMP-3, and MMP-9 were analyzed by immunohistochemistry, and collagen type I and III by Sirius red. LLLT increased the deposition of collagen type I and III in a gradual manner, with significant differences relative to the group aged tendonitis (p<0.001), and in relation to VEGF (p<0.001); decreased expression of MMP-3 and 9 was observed in group aged tendinopathy (p<0.001). LLLT, therefore, increased the production of collagen type I and III, downregulated the expression of MMP-3 and MMP-9, and upregulated that of VEGF, with age and age-induced hormonal deficiency.
O objetivo deste estudo foi investigar O Efeito da terapia Laser de baixa intensidade no Colágeno tipo I e III, Metaloproteinase e VEGF em Modelo Experimental de Tendinopatia, em ratas fêmeas idosas. A colagenase foi induzida na região peritendínea no tendão Calcâneo dos animais. Quarenta e duas ratas Wistar (Norvegicus albinus) foram utilizadas no estudo, com grupos consistindo de 36 animais idosos (18 meses de idade; com média da massa, 517.7 ± 27.54 g) e 6 animais adultos (12 semanas de idade; média da massa, 266, 19:30 0 ± g). Os animais foram randomizados e divididos em três grupos, Controle, tendinopatia idoso e tendinopatia Laser idoso, e subdividido em três grupos experimentai, 7, 14 e 21 dias. O tratamento com Laser de baixa intensidade foi aplicado utilizando um Laser Arseneto de Galium e Alumínio (AsGaAl) (Theralaser, DMC®) operando no comprimento de onda de 830nm (±10nm), 50 mW de potência, saída do feixe de 0,028 cm2, densidade de energia de 107J /cm2, densidade de potência 1,7 w/cm2 e energia de 3 J, com uma frequência de 3 vezes por semana, até a data da eutanásia (7, 14 e 21 dias). Foram analisados VEGF e MMP 3 e 9 por meio de Imunohistoquímica e Colágeno tipo I e III por Sirius red. Os resultados sugerem que a Terapia a Lesar de Baixa Intensidade foi capaz de aumentar os níveis de Colágeno tipo I e III de maneira gradual e com significante diferença no grupo Tendinpatia Idoso (p<0,001), isso pode ser observado em relação ao VEGF (p<0.001), foi também observado diminuição da expressão de MMP 3 e MMP 9 em relação ao grupo tendinopatia Idoso, com diferença estatística (p<0,001). Nós concluímos que a terapia Laser de Baixa Intensidade foi capaz de diminuir a produção de Colágeno tipo I e III, reduzir a expressão de MMP 3 e 9, e aumentar a expressão de VEGF, mesmo nas ratas fêmeas idosas com deficiência hormonal causada pela idade.
Alsousou, Joseph. "Platelet rich plasma in regenerative tendon repair mechanobiological interactions and clinical application." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:2692c00e-0c0d-4096-8daa-c00ad47fd03d.
Повний текст джерелаVogel, Gunilla. "Dorsalflexion i första metatarsofalangealleden och naviculare position hos motionärer med Achilles tendinopati i mittportionen." Thesis, Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-3811.
Повний текст джерелаAbstract Aim: The aim of this study was to a) investigate if recreational athletes diagnosed with midportion Achilles tendinopathy (AT) have restricted dorsiflexion in the 1st metatarsophalangeal (MTP) joint on affected side, compared to non-affected, b) investigate whether there are side side differences in naviculare position and also c) investigate which method - goniometric measurement (GM) or visual estimation (VE) - is preferable in measurement for dorsiflexion in the 1st MTP joint. The questions were: Is there a difference for dorsiflexion in the 1st MTP joint when comparing the affected side with the unaffected? Is there a side difference for the height of the medial longitudinal arch? Is there a side difference for the size of midtarsal vertical movement? Are there differences between the values of dorsiflexion in the 1st MTP joint using the respective method (GM and VE) when comparing the affected side to the unaffected? Does the method VE exhibit concurrent validity with the method GM in measuring dorsiflexion for the 1st MTP joint? Method: 28 patients with unilateral AT (mean age 39 years, weeks of symptoms median =12) were consecutively recruted. The patients were diagnosed clinically, the lower extremity was screened for restrictions in the sagittal plane, naviculare height (NH) was measured in two positions and navicular drop (ND) was calculated. The 1st MTP joint was photographed three times in a standardized position, and the dorsiflexion was measured by GM in the photos, which were randomized. The highest value measured for dorsiflexion in the 1st MTP joint for each foot was used for VE, and a protocol was used to standardize. Results: There was a significantly restricted dorsiflexion (p=0.015) in the 1st MTP joint on the affected side for recreational athletes with AT. There was no significance between the height of the longitudinal arch (NH) or the size of midtarsal vertical movement (ND) when comparing the affected side to the unaffected. Using GM there was a significantly higher mean (p= 0.0009) for dorsiflexion in the 1st MTP joint compared to VE. The mean was also significantly higher for dorsiflexion in the 1st MTP joint, using GM as well as VE, on the unaffected side, compared to the affected. When the methods VE and GM were examined for covariance, Pearson's correlation test showed r = 0.90 to the unaffected side and r = 0.86 to the affected side. Conclusions: Recreational athletes with unilateral AT have a restriction of dorsiflexion in the 1st MTP joint on the affected side compared to the unaffected. There were no side differences found between naviculare position. GM is to be chosen over VE for clinical measurements of dorsiflexion in the 1st MTP joint, since VE underestimated the range of motion.
Bignami, Stefano. "Quale efficacia dell’esercizio terapeutico nella Tendinopatia Achillea? Una Revisione della Letteratura esistente." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amslaurea.unibo.it/25936/.
Повний текст джерелаMüller, Steffen. "Die belastungsspezifische neuromuskuläre Antwort bei Athleten mit Tendinopathie der Achilles- oder Patellarsehne : Analysen der funktionalen und therapeutischen Effekte eines sensomotorischen Trainings." Potsdam Univ.-Verl. Potsdam, 2008. http://deposit.d-nb.de/cgi-bin/dokserv?id=3095894&prov=M&dokv̲ar=1&doke̲xt=htm.
Повний текст джерелаMüller, Steffen. "Die belastungsspezifische neuromuskuläre Antwort bei Athleten mit Tendinopathie der Achilles- oder Patellarsehne Analysen der funktionalen und therapeutischen Effekte eines sensomotorischen Trainings." Potsdam Univ.-Verl, 2007. http://d-nb.info/988467984/04.
Повний текст джерелаMüller, Steffen [Verfasser]. "Die belastungsspezifische neuromuskuläre Antwort bei Athleten mit Tendinopathie der Achilles- oder Patellarsehne : Analysen der funktionalen und therapeutischen Effekte eines sensomotorischen Trainings / Steffen Müller." Potsdam : Univ.-Verl, 2008. http://d-nb.info/1000231453/34.
Повний текст джерелаRossi, Rafael Paolo. "Avaliação do processo de reparo tecidual em tendão de Aquiles de ratos após indução de tendinopatia por colagenase: efeito do laser de baixa intensidade e de drogas anti-inflamatórias." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-23012012-131838/.
Повний текст джерелаIntroduction: Achilles tendinopathy is characterized by presence of classical signs of inflammatory response such as edema, pain, and structural changes in tissue. In this study we evaluated the repair process and tissue reorganization of rats tendons submitted to collagenase induced tendinopathy, being posteriorly treated with low-level laser therapy, steroidal anti-inflammatory and non-steroidal anti-inflammatory. Materials and Methods: Female Wistar rats were submitted to transcutaneous collagenase injection (100mg/tendon) at paws peritendinous site and posteriorly divided and treated in following groups: laser (3J), potassium diclofenac (1.1mg/kg), and dexamethason (0.02mg/kg). Histomorphological analyses were made including findings score, tissue collagen amount and collagen fibers aggregation/organization levels. Results and Discussion: Collagenase produced enhancement of inflammatory cells, edema and hemorrhage. Laser therapy showed be the better option between tested treatments, decreasing inflammatory response, increasing collagen concentration and mantaining collagen fibers organization.
Yun-BinLiu and 劉允斌. "Effect of Rehabilitation Exercise on Achilles tendinopathy- a Rat Model." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/09937516324213648871.
Повний текст джерела國立成功大學
生物醫學工程學系
102
The Achilles tendon plays an important role in plantar flexion of ankle joint. The Achilles tendinopathy often occurs in athletes and it associates with tenderness, pain, and the long duration of conservative treatments. Strengthening and stretching exercises are commonly adapted to improve the pain score or activity level in clinical rehabilitation. The purpose of this study is to investigate the effects of different rehabilitation protocols on mechanical properties and sonographic assessments of the Achilles tendon with a rat model. The tendinopathy rat model was established by injecting collagenase in the Achilles tendon. After resting for 4 weeks, 12-week-old male Sprague-Dawley rats with a medium severity level of sonographic assessments were randomly assigned to 4 groups, eccentric group, concentric group, passive range of motion group, and control group. A self-designed rehabilitation system was developed and used to control the angular velocity, the range of motion of ankle joint and contraction types, as well as generate calf muscles contraction using electrical stimulation. After 6 weeks of training, the sonographic assessments were tested. Then the specimen, including parts of gastrocnemius, Achilles tendon and calcaneus, was collected for the following tensile testing. By Mann-Whitney analysis, there are significant differences between EE and CE groups in their maximum force (p=0.032) and maximum stress (p=0.032). However, neither maximum stress nor maximum force has correlation with integral torque. The results might explain why isolated eccentric exercise has better clinical effects on healing Achilles tendinopathy than isolated concentric exercise. The higher torque exerted from eccentric than concentric contraction may not be the dominant impact on why eccentric exercise is more effective than concentric exercise for healing Achilles tendon. In addition, correlating the results of mechanical testing with sonographic assessments, there are moderately negative correlation between Young’s modulus and echogenicity (r=-0.483), as well as moderate correlation between cross-sectional area and vascularity (p=0.469). These results provide the links from the non-invasive sonographic assessments to the mechanical properties of the tendon.
Mostecká, Dagmar. "Tendinopatie achillovy šlachy jako důsledek funkčních poruch pohybového aparátu." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-274412.
Повний текст джерелаRobinson, Jennifer Mary. "Assessment of the Visa-A questionnaire for Achilles tendinopathy and its correlation with imaging." Thesis, 2000. http://hdl.handle.net/2429/10746.
Повний текст джерелаYun-PuTsai and 蔡雲圃. "Quantitative analyses of gait behavior and nociception of radiofrequency treated acute Achilles tendinopathy in rat." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/40284343435145043950.
Повний текст джерела國立成功大學
細胞生物及解剖學研究所
100
Achilles tendinopathy is caused by excessive use or loading of physical force of the tendon and it is commonly occurred among athletes. The patient is in general treated conservatively. Radiofrequency (RF) has been proven to be an effective method to relieve pain in those patients. Currently, the pathophysiology of tendinopathy is thought to be associated with a failed healing response. In this study, collagenolytic agent was injected to the Achilles tendon to generate tendinopathy in Sprague-Dawley (SD) rat. The effects of RF, specifically, on changes of pain-related neuropeptides release and gait behavior in acutely post RF treated SD rats were examined. Collagenase І (0.3mg/20ul) or Phosphate-Buffer Saline (PBS) was injected to the rat Achilles tendon as the experiment and sham control groups. SD rats underwent skin incision over the Achilles tendon were served as normal control. The experiment was following a time-course schedule to exam post collagenase I injection on 1,3,5,7,9,11,13,15 days to examine pathohistology and gait changes. RF treatment was on day 8 after collagenase injection. Substance P, Calcitonin gene related peptide(CGRP) and Galanin expressions were examined by immunohistochemical (IHC) staining to evaluate nociception. β III tubulin immunofluorescence (IF) staining was used to evaluated nerve fiber change. Masson trichrome staining of tendon was used to examine collagen change. The gait parameters recorded and analyzed in this study included gait pattern time (stance phase, double stance phase, walk speed), distance (step length, step width, stride length, print length, intermediary toe-spread), and range of motion (initial contact, mid‐stance, pre‐swing, mid‐swing, foot angle). Substance P and CGRP IHC staining showed that the nociception was increased on the days 1, 3, 5, 7, but Substance P (n=5, p〈0.001) and CGRP (n=5, p〈0.001) decrease after RF treatment. Galanin IHC staining showed that there was no significance change in rats underwent RF treatment. β III tubulin IF staining showed that the nerve fiber density and diameter increased on the days 1, 3, 5, 7 when compared to the normal controls. However, the nerve fibers diameter (n=5, p〈0.001) were decreased after RF treatment. Masson trichrome staining showed that the tension increased after chemical injury. In post-RF treated groups, the stance phase (n=7, p〈0.05), step length (n=8, p〈0.05), intermediary toe-spread (n=8, p〈0.01) and pre‐swing (n=8, p〈0.05), were significantly different from shame and normal controls. These changes suggest that RF treatment improves gait behavior in acute tendinopathy, which allows rat ambulate toward to the normal gait pattern. Nociception is different in different time intervals, which may cause differences in gait pattern. RF treatment decreases nociception neuropeptides release, decrease nerve fiber diameter in injured Achilles tendon, improves pain and makes rat walk better. In conclusion, this study provides the first detailed analysis of RF effects on acute Achilles tendinopathy in rat. Whether these data would apply to the patients with pain in early stage of Achilles tendinopathy might require further evaluation.
Voleský, Kryštof. "Analýza rizikových faktorů pro vznik tendinopatií u běžců - literární rešerše." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-447443.
Повний текст джерела