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Добірка наукової літератури з теми "Acbp / dbi"

Автор: Grafiati

Опубліковано: 7 жовтня 2023

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Статті в журналах з теми "Acbp / dbi"

Li, Sijing, Adrien Joseph, Isabelle Martins, and Guido Kroemer. "Elevated plasma levels of the appetite-stimulator ACBP/DBI in fasting and obese subjects." Cell Stress 5, no. 7 (July 12, 2021): 89–98. http://dx.doi.org/10.15698/cst2021.07.252.

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Eukaryotic cells release the phylogenetically ancient protein acyl coenzyme A binding protein (ACBP, which in humans is encoded by the gene DBI, diazepam binding inhibitor) upon nutrient deprivation. Accordingly, mice that are starved for one to two days and humans that undergo voluntary fasting for one to three weeks manifest an increase in the plasma concentration of ACBP/DBI. Paradoxically, ACBP/DBI levels also increase in obese mice and humans. Since ACBP/DBI stimulates appetite, this latter finding may explain why obesity constitutes a self-perpetuating state. Here, we present a theoretical framework to embed these findings in the mechanisms of weight control, as well as a bioinformatics analysis showing that, irrespective of the human cell or tissue type, one single isoform of ACBP/DBI (ACBP1) is preponderant (~90% of all DBI transcripts, with the sole exception of the testis, where it is ~70%). Based on our knowledge, we conclude that ACBP1 is subjected to a biphasic transcriptional and post-transcriptional regulation, explaining why obesity and fasting both are associated with increased circulating ACBP1 protein levels.

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Burgi, B., W. Lichtensteiger, and M. Schlumpf. "Diazepam-binding inhibitor/acyl-CoA-binding protein mRNA and peripheral benzodiazepine receptor mRNA in endocrine and immune tissues after prenatal diazepam exposure of male and female rats." Journal of Endocrinology 166, no. 1 (July 1, 2000): 163–71. http://dx.doi.org/10.1677/joe.0.1660163.

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Peripheral benzodiazepine (BDZ) receptor (PBR) and diazepam-binding inhibitor/acyl-CoA-binding protein (DBI/ACBP) characterized as a ligand at central BDZ receptors, at PBR with involvement in the regulation of steroidogenesis, and as an intracellular acyl-CoA transporter, are both known to interact with BDZ in adult systems. We investigated their expression after prenatal exposure to BDZ. Diazepam (1.25 mg/kg per day s.c.) was administered to time-pregnant Long Evans rats from gestational day (GD) 14 to 20. Expression of mRNAs encoding for PBR and for DBI/ACBP was studied in the same animals with (33)P-labeled 60 mer oligonucleotides (oligos) by in situ hybridization at GD20, and with (32)P-labeled oligos by Northern blot in steroidogenic and immune organs at postnatal day (PN) 14 and in adult offspring. Prenatal diazepam increased DBI/ACBP mRNA expression in male fetal adrenal and in fetal and PN14 testis. Thymus exhibited increased DBI/ACBP mRNA in male fetuses and in adult female offspring, and reduced organ weight at PN14 in both sexes. In female spleen, an increase in DBI/ACBP mRNA and a decrease in PBR mRNA was seen at PN14. Apart from the finding in spleen, no drug-induced changes in PBR mRNA were observed. The effects of prenatal diazepam were superimposed on treatment-independent sex differences in DBI/ACBP mRNA and PBR mRNA expression. Our data indicate that expression of DBI/ACBP mRNA in steroidogenic and immune organs can be affected by exposure to BDZ during ontogeny, while PBR mRNA expression appears to be less sensitive. They further reveal marked sex differences in the developmental patterns of the two proteins during pre- and postpubertal ontogeny.

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Östenson, Claes-Göran, Bo Ahrén, Sven Karlsson, Jens Knudsen, and Suad Efendic. "Inhibition by rat diazepam-binding inhibitor/acyl-CoA-binding protein of glucose-induced insulin secretion in the rat." European Journal of Endocrinology 131, no. 2 (August 1994): 201–4. http://dx.doi.org/10.1530/eje.0.1310201.

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Östenson C-G, Ahrén B, Karlsson S, Knudsen J, Efendic S. Inhibition by rat diazepam-binding inhibitor/ acyl-CoA-binding protein of glucose-induced insulin secretion in the rat. Eur J Endocrinol 1994;131:201–4. ISSN 0804–4643 Diazepam-binding inhibitor (DBI) has been localized immunohistochemically in many organs. In porcine and rat pancreas, DBI is present in non-B-cells of the pancreatic islets. Porcine peptide also has been shown to suppress insulin secretion from rat pancreas in vitro. Recently, acyl-CoA-binding protein (ACBP) was isolated from rat liver and shown to be identical structurally to DBI isolated from rat brain. Using this rat DBI/ACBP, we have studied its effects on glucose-stimulated insulin secretion in the rat, both in vivo and in isolated pancreatic islets. Infusion iv of rDBI/ACBP (25 pmol/min) during glucose stimulation induced a moderate and transient reduction of plasma insulin levels. Moreover, rDBI/ACBP suppressed insulin release from batch-incubated isolated islets, stimulated by 16.7 mmol/l glucose, by 24% at 10 nmol/l (p < 0.05) and by 40% at 100 nmol/l (p < 0.01). The peptide (100 nmol/l) also inhibited the insulin response to glucose (16.7 mmol/l) from perifused rat islets by 31% (p < 0.05), mainly by affecting the acute-phase response. Finally, incubation of isolated islets in the presence of rDBI/ACBP antiserum (diluted 1:100 and 1:300) augmented the insulin response to 16.7 mmol/l glucose (p < 0.05 or even less). We conclude that rDBI/ACBP, administered iv or added to the incubation media, suppresses insulin secretion in the rat but that the effect is moderate despite the high concentration used. It is therefore unlikely that the peptide modulates islet hormone release, acting as a classical hormone via the circulation. However, the occurrence of DBI/ACBP in the islets and the enhancing effect by the rDBI/ACBP antibodies on glucose-stimulated insulin release suggest that the peptide is a local modulator of insulin secretion. C-G Östenson, Department of Endocrinology, Karolinska Hospital, S-171 76 Stockholm, Sweden

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Sica, Valentina, Isabelle Martins, Omar Motiño, José M. Bravo-San Pedro, and Guido Kroemer. "Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects." Adipocyte 9, no. 1 (January 1, 2020): 116–19. http://dx.doi.org/10.1080/21623945.2020.1736734.

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Knudsen, Jens, Susanne Mandrup, Jan Trige Rasmussen, Per Hove Andreasen, Flemming Poulsen, and Karsten Kristiansen. "The function of acyl-CoA-binding protein (ACBP)/Diazepam binding inhibitor (DBI)." Molecular and Cellular Biochemistry 123, no. 1-2 (1993): 129–38. http://dx.doi.org/10.1007/bf01076484.

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Bouyakdan, Khalil, Bouchra Taïb, Lionel Budry, Shangang Zhao, Demetra Rodaros, Ditte Neess, Susanne Mandrup, Nils J. Faergeman, and Thierry Alquier. "A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes." Journal of Neurochemistry 133, no. 2 (February 6, 2015): 253–65. http://dx.doi.org/10.1111/jnc.13035.

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Budry, Lionel, Khalil Bouyakdan, Stephanie Tobin, Demetra Rodaros, Ann-Britt Marcher, Susanne Mandrup, Stephanie Fulton, and Thierry Alquier. "DBI/ACBP loss-of-function does not affect anxiety-like behaviour but reduces anxiolytic responses to diazepam in mice." Behavioural Brain Research 313 (October 2016): 201–7. http://dx.doi.org/10.1016/j.bbr.2016.06.052.

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Bravo-San Pedro, José Manuel, Valentina Sica, Isabelle Martins, Gerasimos Anagnostopoulos, Chiara Maiuri, and Guido Kroemer. "Cell-autonomous, paracrine and neuroendocrine feedback regulation of autophagy by DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein): the obesity factor." Autophagy 15, no. 11 (September 5, 2019): 2036–38. http://dx.doi.org/10.1080/15548627.2019.1662585.

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Hayden, Melvin. "Hypothesis: Astrocyte Foot Processes Detachment from the Neurovascular Unit in Female Diabetic Mice May Impair Modulation of Information Processing—Six Degrees of Separation." Brain Sciences 9, no. 4 (April 14, 2019): 83. http://dx.doi.org/10.3390/brainsci9040083.

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Astrocytes via their foot processes (ACfp) are specialized connecting cells, and they structurally connect the neurovascular unit (NVU) mural cells to neurons. Astrocytes provide homeostatic mechanisms for structural connections and provide communication between the NVU and regional neurons for functional hyperemia in regions of increased neuronal activity (neurovascular coupling). Previously, our group has demonstrated a detachment, separation, and retraction of ACfp in diabetic db/db females (DBC). It was hypothesized that a loss of adherent ACfp/NVU could result in the known impaired cognition in DBC. Additionally hypothesized was that empagliflozin treatment could protect DBC ACfp/NVU remodeling. This study demonstrates a significant loss of ACfp/NVU numbers in DBC and a protection of this loss by empagliflozin treatment (DBE). The number of intact ACfp/NVU was 6.45 ± 1.1 in control heterozygous (CKC) vs. 1.88 ± 0.72 in DBC (p < 0.05) and 5.86 ± 0.88 in DBE vs. DBC (p < 0.05) by visually hand-counting the capillary NVUs (22 in CKC, 25 in DBC, and 22 in DBE). These findings suggest that empagliflozin provides neuroprotection via the prevention of ACfp separation in DBE as compared to diabetic DBC. Furthermore, a loss of ACfp/NVU numbers in DBC may correspond with a negative modulation of informational processing, and the protection of ACfp/NVU numbers could provide a protective modulation in DBE models.

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Gendreau, Elizabeth, Lamiae Benhayou-Sadafiyine, Marie-Anne Le Dain, and Joshua Summers. "Ranking Absorption Practices of Knowledge for Collaborative Innovation: Which is the Ideal Multi Criteria Decision Method." Proceedings of the Design Society: International Conference on Engineering Design 1, no. 1 (July 2019): 2337–46. http://dx.doi.org/10.1017/dsi.2019.240.

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AbstractThis paper focuses on evolving an absorptive capacity (ACAP) assessment tool designed to help firms understand their ACAP maturity in processing external knowledge. ACAP maturity is evaluated based on a firm's capacity and willingness to do relevant ACAP practices. Although an earlier version of the ACAP tool was able to evaluate maturity and highlight immature practice, it could not determine how critical these practices were for improvement action. Thus, a means of eliciting the importance of practices and aggregating it with their ACAP maturity evaluations is needed. This paper provides summaries of the subjective weight elicitation methods and aggregation techniques which were identified from the domain of multi-criteria decision making. Criteria for comparing these methods are defined and analyzed to determine the most appropriate methods for the current application. The SRF method for subjective weight elicitation, aggregated with the maturity evaluations through weight sum models, is deemed the most appropriate for the current application. During testing with users, the SRF procedure was found to suffer from various usability concerns which will be investigated in future work.

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Більше джерел

Дисертації з теми "Acbp / dbi"

Montégut, Léa. "Role of acyl-coenzyme A binding protein in age-related diseases and cancer." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL073.

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La protéine se liant aux acyl-coenzymes A (ACBP), aussi appelée inhibiteur de liaison du diazépam (DBI), est une protéine ubiquitaire et fortement conservée au sein des organismes eucaryotes. Chez les mammifères, elle joue un rôle double : l'ACBP intracellulaire se lie aux acides gras activés (acyl-coA) et, lorsqu'elle est sécrétée, ACBP joue le rôle d'une hormone régulatrice du métabolisme et de l'obésité. L'analyse de données publiques démontre une tendance à l'augmentation d'ACBP dans de nombreuses pathologies caractérisées par un dérèglement systémique : c'est le cas, entre autres, chez les patients atteints de stéatose hépatique, de formes graves du VIH ou du COVID-19 et de certains cancers. Enfin, les concentrations d'ACBP dans le plasma sont positivement corrélées avec l'âge des individus. Il a récemment été démontré chez la souris que la modulation des niveaux d'ACBP circulant permettait de contrôler les paramètres métaboliques des animaux. L'obésité et le syndrome métabolique étant parmi les premiers facteurs de risque environnementaux pour le développement des maladies liées au vieillissement, comme les maladies cardiovasculaires et le cancer, nous nous sommes intéressés dans ces travaux à déterminer si ces maladies pouvaient être annoncées par une élévation des niveaux d'ACBP circulants. L'analyse de cohortes d'individus déclarés en bonne santé a révélé une augmentation d'ACBP dans le cas de la survenue prochaine d'événements cardiovasculaire ou de cancer. L'utilité d'ACBP ensuite été explorée dans plusieurs contextes précliniques. D'une part, la neutralisation de cette protéine étend la durée de vie des levures et est protectrice du vieillissement accéléré du cœur chez la souris, causé par les anthracyclines (une classe de chimiothérapies couramment utilisée et connue pour ses effets cardiotoxiques). Dans le cadre du cancer, la modulation de ce checkpoint métabolique a un impact positif sur l'immunosurveillance tumorale et améliore la réponse aux traitements par chimio-immunothérapie chez la souris. Ainsi, notre étude révèle qu'ACBP pourrait être un biomarqueur de l'« âge biologique » des patients, son élévation annonçant la survenue imminente de maladies liées à l'âge. Au-delà de sa valeur prédictive, les premiers essais précliniques démontrent que sa neutralisation est une piste prometteuse pour améliorer la santé métabolique des individus, qui peut être exploitée pour prévenir ou améliorer la réponse aux traitements des maladies cardiovasculaires et du cancer
Acyl-coenzyme A binding protein (ACBP), also known as diazepam binding inhibitor (DBI), is a ubiquitous and highly conserved protein in eukaryota. In mammals, it plays a dual role: intracellular ACBP binds to activated fatty acids (acyl-CoAs) and, when secreted, ACBP acts as a peptide hormone regulating metabolism and obesity. The analysis of publicly available datasets demonstrates a tendency for increased ACBP in physio-pathological contexts, such as hepatic steatosis, severe forms of HIV or COVID-19, and certain cancers. Additionally, plasma ACBP concentrations are positively correlated with chronological age.Recent studies in mice have shown that modulation of circulating ACBP levels can also control metabolic parameters in animals. Obesity and metabolic syndrome are among the primary environmental risk factors for the development of age-related diseases, such as cardiovascular diseases and cancer, therefore our research aimed to determine if these diseases could be preceded by a modification in circulating ACBP levels.In cohorts of apparently healthy of individuals, we detected an elevation of ACBP in patients who would imminently develop cardiovascular events or cancer. The utility of this aging biomarker was further explored in different preclinical contexts. On one hand, neutralization of the protein extends the lifespan of yeast and, in mice, it protects against accelerated aging of the heart caused by anthracyclines (a class of chemotherapies commonly used and known for their cardiotoxic effects). In the context of cancer, modulation of this metabolic checkpoint has a positive impact on tumor immunosurveillance and improves the response to chemotherapy-immunotherapy treatments in mice. Thus, our study reveals that ACBP could be a biomarker of patients' "biological age,", with its elevation indicating the imminent onset of age-related diseases. Beyond its predictive value, initial preclinical trials demonstrate that neutralization of ACBP is a promising option for improving metabolic health in patients, which could be exploited to prevent or enhance the response to treatments for cardiovascular diseases and cancer

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Li, Jun 1966 Mar 15. "Structural and functional studies of an ACYL-ACP thioesterase from bioluminescent bacteria." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36637.

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Vibrio harveyi myristoyl-ACP thioesterase (LuxD) differs from most thioesterases in substrate specificity, turnover rate and rate limiting step with the deacylation step occurring at a very slow rate. A serine residue, Ser114, which is the central serine in the sequence A-x-S-x-S and not part of the standard G-x-S-x-G consensus motif, has been identified as the active site nucleophile. Ser114 together with His241 and Asp211, form a catalytic triad with a mechanism similar to that of the esterase/lipase family. Tryptophan fluorescence of the V. harveyi thioesterase and its tryptophan mutants showed that there is a ligand induced conformational change during acylation of the enzyme and that the fluorescence of tryptophan 213 is specifically enhanced on substrate binding. A chimeric LuxD, constructed from Photobacterium phosphoreum LuxD and Vibrio harveyi LuxD was shown to be hyperactive compared to its parental LuxDs. Studies of this chimera revealed that the carboxyl-terminal half of the thioesterase is the part of the molecule involved with interaction with the synthetase component of the fatty acid reductase complex responsible for synthesis of aldehyde substrate for the luminescent reaction.

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Rapacchi, Stanislas. "Low b-values diffusion weighted imaging of the in vivo human heart." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10012/document.

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L'Imagerie par Résonance Magnétique pondérée en Diffusion (IRM-D) permet l'accès à l'information structurelle des tissus au travers de la lecture du mouvement brownien des molécules d'eau. Ses applications sont nombreuses en imagerie cérébrale, tant en milieu clinique qu'en recherche. Néanmoins le mouvement physiologique créé une perte de signal supplémentaire au cours de l'encodage de la diffusion. Cette perte de signal liée au mouvement limite les applications de l'IRM-D quant à l'imagerie cardiaque. L'utilisation de faibles valeurs de pondération (b) réduit cette sensibilité mais permet seulement l'imagerie du mouvement incohérent intra-voxel (IVIM) qui contient la circulation sanguine et la diffusion des molécules d'eau. L'imagerie IVIM possède pourtant de nombreuses applications en IRM de l'abdomen, depuis la caractérisation tissulaire à la quantification de la perfusion, mais reste inexplorée pour l'imagerie du coeur. Mon travail de thèse correspond à l'évaluation des conditions d'application de l'IRM-D à faibles valeurs de b pour le coeur humain, afin de proposer des contributions méthodologiques et d'appliquer les techniques développées expérimentalement. Nous avons identifié le mouvement cardiaque comme une des sources majeures de perte de signal. Bien que le mouvement global puisse être corrigé par un recalage non-rigide, la perte de signal induite par le mouvement perdure et empêche l'analyse précise par IRM-D du myocarde. L'étude de cette perte de signal chez un volontaire a fourni une fenêtre temporelle durable où le mouvement cardiaque est au minimum en diastole. Au sein de cette fenêtre optimale, la fluctuation de l'intensité atteste d'un mouvement variable résiduel. Une solution de répéter les acquisitions avec un déclenchement décalé dans le temps permet la capture des minimas du mouvement, c.-à-d. des maximas d'intensité en IRM-D. La projection du maximum d'intensité dans le temps (TMIP) permet ensuite de récupérer des images pondérées en diffusion avec un minimum de perte de signal lié au mouvement. Nous avons développé et évalué différentes séquences d'acquisition combinées avec TMIP : la séquence d'imagerie écho-planaire classique par écho de spin (SE-EPI) peut être adaptée mais souffre du repliement d'image ; une séquence Carr-Purcell-Meiboom-Gill combinée avec une préparation d'encodage de diffusion est plus robuste aux distorsions spatiales mais des artefacts de bandes noires empêchent son applicabilité ; finalement une séquence double-SE-EPI compensant les courants de Foucault et pleinement optimisée produit des images IRM-D moins artefactées. Avec cette séquence, l'IRM-D-TMIP permet la réduction significative de la perte de signal liée au mouvement pour l'imagerie cardiaque pondérée en diffusion. L'inconvénient avec TMIP vient de l'amplification du bruit positif d'intensité. Afin de compenser cette sensibilité du TMIP, nous séparons le bruit d'intensité des fluctuations lentes liées au mouvement grâce à une nouvelle approche basée sur l'analyse en composantes principales (PCA). La décomposition préserve les détails anatomiques tout en augmentant les rapports signal et contraste-à-bruit (SNR, CNR). Avec l'IRM-D-PCATMIP, nous augmentons à la fois l'intensité finale et la qualité d'image (SNR) en théorie et expérimentalement. Les bénéfices ont été quantifiés en simulation avant d'être validés sur des volontaires. De plus la technique a montré des résultats reproductibles sur des patients post-infarctus aigue du myocarde, avec un contraste cohérent avec la position et l'étendue de la zone pathologique. Contrairement à l'imagerie cérébrale, l'imagerie IRM-D par faibles valeurs de pondération in vivo doit être différentiée des analyses IRM-D ex-vivo. Ainsi l'IRM-D-PCATMIP offre une technique sans injection pour l'exploration du myocarde par imagerie IVIM. Les premiers résultats sont encourageants pour envisager l'application sur un modèle expérimental d'une maladie cardiovasculaire [etc...]
Diffusion weighted magnetic resonance imaging (DW-MRI, or DWI) enables the access to the structural information of body tissues through the reading of water molecules Brownian motion. Its applications are many in brain imaging, from clinical practice to research. However physiological motion induces an additional signal-loss when diffusion encoding is applied. This motion-induced signal-loss limits greatly its applications in cardiac imaging. Using low diffusion-weighting values (b) DWI reduces this sensitivity but permits only the imaging of intravoxel incoherent motion (IVIM), which combines both water diffusion and perfusion. IVIM imaging has many applications in body MRI, from tissue characterization to perfusion quantification but remains unexplored for the imaging of the heart. The purpose of this work was to evaluate the context of low b-values DWI imaging of the heart, propose methodological contributions and then apply the developed techniques experimentally. We identified cardiac motion as one of the major sources of motion-induced signal loss. Although bulk motion can be corrected with a non-rigid registration algorithm, additional signal-loss remains uncorrected for and prevents accurate DWI of the myocardium. The study of diffusion-weighted signal-loss induced by cardiac motion in a volunteer provided a time-window when motion is at minimum in diastole. Within this optimal time-window, fluctuation of intensity attests of variable remaining physiological motion. A solution to repeat acquisition with shifted trigger-times ease the capture of motion amplitude minima, i.e. DWI-intensity maxima. Temporal maximum intensity projection (TMIP) finally retrieves diffusion weighted images of minimal motion-induced signal-loss. We evaluated various attempts of sequence development with TMIP: usual spin-echo echo-planar imaging (se-EPI) sequence can be improved but suffers aliasing issues; a balanced steady-state free-precession (b-SSFP) combined with a diffusion preparation is more robust to spatial distortions but typical banding artifacts prevent its applicability; finally a state-of-the-art double-spin-echo EPI sequence produces less artifacted DWI results. With this sequence, TMIP-DWI proves to significantly reduce motion-induced signal-loss in the imaging of the myocardium. The drawback with TMIP comes from noise spikes that can easily be highlighted. To compensate for TMIP noise sensitivity, we separated noise spikes from smooth fluctuation of intensity using a novel approach based on localized principal component analysis (PCA). The decomposition was made so as to preserve anatomical features while increasing signal and contrast to noise ratios (SNR, CNR). With PCATMIP-DWI, both signal-intensity and SNR are increased theoretically and experimentally. Benefits were quantified in a simulation before being validated in volunteers. Additionally the technique showed reproducible results in a sample of acute myocardial infarction (AMI) patients, with a contrast matching the extent and location of the injured area. Contrarily to brain imaging, in vivo low b-values DWI should be differentiated from ex vivo DWI pure diffusion measurements. Thus PCATMIP-DWI might provide an injection-free technique for exploring cardiac IVIM imaging. Early results encourage the exploration of PCATMIP-DWI in an experimental model of cardiac diseases. Moreover the access to higher b values would permit the study of the full IVIM model for the human heart that retrieves and separates both perfusion and diffusion information

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Boaria, Andrea. "Biological and integrated control of Frankliniella occidentalis (Pergande) on ornamentals in the northeastern Italy." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423799.

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Laboratory, semi-field and field experiments were conducted with the aim of identifying biological and integrated control strategies to be applied against Frankliniella occidentalis. We studied the spatial and temporal distribution of the main thrips pests in greenhouses and potential antagonists in some greenhouses characterized by a different level of lateral openings and a rose garden in the open. The second experiment was planned to show that opening greenhouse structures are not automatically related to an increase in thrips problems on ornamental crops. The third experimental study has been undertaken with the aim of evaluating the impact of some biological control agents (BCAs) on Frankliniella occidentalis population. In the fourth experiment, the effect of a fungal strain of Beauveria bassiana on F. occidentalis reached the highest levels when residual and topical exposures were combined
Sono stati condotti esperimenti di laboratorio, semi-campo e campo (serra) volti a individuare strategie di lotta biologica ed integrata da applicare contro Frankliniella occidentalis. E’ stata studiata la distribuzione spazio-temporale dei principali tripidi fitofagi delle serre e dei potenziali antagonisti in alcune serre caratterizzate da un diverso livello di aperture laterali e in un roseto a cielo aperto. La seconda ricerca sperimentale è stata intrapresa con lo scopo di dimostrare che il grado di apertura delle serre verso l'ambiente esterno non implica un maggiore incremento delle problematiche correlate ai tripidi su colture ornamentali. Il terzo studio è stato condotto con l'obbiettivo di valutare l'impatto di alcuni agenti di controllo biologico su F. occidentalis. Nel quarto esperimento, l'effetto di un ceppo fungino di Beauveria bassiana su F. occidentalis ha raggiunto i livelli più elevati quando l’esposizione topica è stata combinata con quella residuale

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Landrock, Danilo. "Acyl CoA Binding Protein (ACBP) Gene Ablation Induces Pre-Implantation Embryonic Lethality in Mice." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-9003.

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Unique among the intracellular lipid binding proteins, acyl CoA binding protein (ACBP) exclusively binds long chain fatty acyl CoAs (LCFA-CoAs). To test if ACBP is an essential protein in mammals, the ACBP gene was ablated by homologous recombination in mice. While ACBP heterozygotes appeared phenotypically normal, intercrossing of the heterozygotes did not result in any live homozygous deficient (null) ACBP^(-/-) pups. Heterozygous and wild type embryos were detected at all postimplantation stages, but no homozygous ACBP null embryos were obtained– suggesting that an embryonic lethality occurred at a preimplantation stage of development, or that embryos never formed. While ACBP null embryos were not detected at any blastocyst stage, ACBP null embryos were detected at the morula (8- cell), cleavage (2-cell), and zygote (1-cell) preimplantation stages. Two other LCFACoA binding proteins, sterol carrier protein-2 (SCP-2) and sterol carrier protein-x (SCPx) were significantly upregulated at these stages. These findings demonstrate for the first time that ACBP is an essential protein required for embryonic development and its loss of function may be initially compensated by concomitant upregulation of two other LCFA-CoA binding proteins only at the earliest preimplantation stages. The fact that ACBP is the first known intracellular lipid binding protein whose deletion results in embryonic lethality suggests its vital importance in mammals.

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CAVAGNUOLO, MICHELA. "Flussi Migratori ed European National-Building Process. Verso una nuova classificazione delle Politiche Migratorie Europee." Doctoral thesis, 2022. http://hdl.handle.net/11573/1629941.

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L’immigrazione dalla nascita degli Stati-nazione e dall’imposizione delle frontiere, non è solo una questione di movimenti della popolazione, è un meccanismo complesso in cui intervengono gli Stati riceventi, le politiche di categorizzazione, le politiche di immigrazione, quelle di asilo, la gestione delle frontiere esterne (Commissione Europea, 2019), le reazioni delle società nei confronti nuovi arrivati, i Paesi di origine e gli stessi migranti (Ambrosini, 2011). Il percorso appena delucidato prende il nome di National-Building Process (Zanfrini, 2016, 7) frutto delle scelte politiche-istituzionali di ogni Paese che ne definisce le peculiarità ideologiche. Tutti gli Stati, europei e non, ad oggi, adottano una politica di contrasto delle frontiere in ragione della crescente domanda di mobilità; questa situazione ha portato alla nascita di un’economia di frontiera che ha generato meccanismi di sbarchi illegali, falsificazione dei documenti, attraversamenti marittimi, matrimoni combinati ed ingressi nei Paesi con visti turistici utilizzati con l’intento di poter sfuggire poi alla legge. Tutti questi meccanismi aumentano la complessità del fenomeno. In letteratura sono stati presi in analisi diversi fattori per studiare i flussi migratori, primo fra tutti il fattore economico (Bertolini, Pistoresi, Zaghi, 2006, 30) sulla base di studi principalmente econometrici, a seguire, il mercato del lavoro, la relazione tra i Paesi, il ricongiungimento e la regolazione politica (Commissione Europea, 2019). La regolazione politica delle migrazioni non sembra essere un fattore di spinta con il quale spiegare il fenomeno migratorio (assimilabile principalmente ai fattori di tipo economico), ma al contrario sembra essere un fattore di attrazione verso uno o l’altro Paese. Il fattore politico, secondo Ambrosini, spiega le modalità delle migrazioni, l’orientamento verso un Paese apparentemente più accessibile ma non la scelta stessa di partire. Ma cosa spinge invece un Paese ad adottare un tipo di politica migratoria piuttosto che un’altra? Quali sono i principali fattori che influenzano tale scelta? E che ruolo ricoprono i flussi in questa scelta politica? Ciò che nella letteratura risulta essere ancora incerto sono appunto questo tipo di considerazioni. Cercare una risposta è difficile perché bisogna tenere conto che la spiegazione delle migrazioni non può prendere in considerazione nessuno dei fattori appena descritti in maniera esclusiva, necessità di un approccio multi-causale, di un disegno che tenga conto della complessità del fenomeno, dove si intrecciano diversi fattori che possono a sua volta assumere importanza diversa rispetto ai diversi periodi economico-storico-politici di un Paese. Attraverso la costruzione di un disegno longitudinale comparato (Biolcati-Rinaldi, Vezzoni 2012; Caputo, Felaco, Punziano, 2017) che permette di prendere in considerazione più contesti (Paesi UE) e più punti nel tempo [T0: 2008 (Post crisi economica; Trattato europeo sull’immigrazione); T1: 2013 (5 anni dalla prima rilevazione; post primavera araba e pre crisi migratoria); T2: 2018 (5 anni dalla seconda rilevazione; post crisi migratoria e implementazione Agenda Europea del maggio 2015)] l’obiettivo principale della ricerca è di capire quale fattore, tra quelli demografici, economici, politico-culturali e sociali influenzano o meno la scelta dei Paesi UE nell’adottare un tipo di politica migratoria tendente all’apertura o alla chiusura. Nello specifico, si vogliono studiare le connessioni e le correlazioni tra la dimensione legislativa che i Paesi UE adottano e le dimensioni sopradescritte sino ad individuare quali e quanto tali fattori influenzano il tipo di politica migratorie europea. La costruzione del modello è successiva alla ricostruzione delle principali teorie della sociologia delle migrazioni, dei modelli sociologici di spiegazione di queste, delle leggi e dei trattati stipulati dall’Unione Europea negli anni. Tenendo conto delle implementazioni legislative sulle migrazioni da parte dell’Unione Europea si è deciso di focalizzarsi sull’Agenda europea sulle migrazioni (2015) che ad oggi rispecchia la politica globale dell’Unione nel campo preso in analisi e quindi di osservare come si sono comportati i Paesi sull’implementazione delle politiche migratorie prima e dopo l’intervento legislativo europeo.

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Книги з теми "Acbp / dbi"

Acp Dba 110 Database Concepts. Course Technology, 2016.

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Acp Using Financial Accting Information : Alternative to Debi: Alternative to Debi. Cengage South-Western, 2014.

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Частини книг з теми "Acbp / dbi"

Knudsen, Jens, Susanne Mandrup, Jan Trige Rasmussen, Per Hove Andreasen, Flemming Poulsen, and Karsten Kristiansen. "The function of acyl-CoA-binding protein (ACBP)/Diazepam binding inhibitor (DBI)." In Cellular Fatty Acid-Binding Proteins II, 129–38. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3096-1_17.

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Sica, Valentina, Isabelle Martins, Federico Pietrocola, and José Manuel Bravo-San Pedro. "Quantification of intracellular ACBP/DBI levels." In Methods in Cell Biology, 111–22. Elsevier, 2021. http://dx.doi.org/10.1016/bs.mcb.2020.12.004.

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Тези доповідей конференцій з теми "Acbp / dbi"

Mao, Shaojuan, Yongqing Huang, Hongming Gu, Baoying Liu, Xiaofeng Duan, and Xiaomin Ren. "A Novel Filter Based on a Subwavelength Grating Focusing Reflector and a DBR." In 2018 Asia Communications and Photonics Conference (ACP). IEEE, 2018. http://dx.doi.org/10.1109/acp.2018.8595803.

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Tian, Yuxin, Bing Xiong, Changzheng Sun, Zhibiao Hao, Jian Wang, Lai Wang, Yanjun Han, Hongtao Li, and Yi Luo. "150 GHz Bandwidth Modified Uni-traveling-carrier Photodiodes with 2.45 dBm Saturation Output Power." In 2022 Asia Communications and Photonics Conference (ACP). IEEE, 2022. http://dx.doi.org/10.1109/acp55869.2022.10088569.

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Liu, Mingsheng, Chengcheng Li, Guoyu Li, Yan Li, and Kang Yang. "The Tunable DBR Fiber Laser Based on Closed-loop PZT." In Asia Communications and Photonics Conference and Exhibition. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/acp.2011.83071v.

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Qiu, Yinghui, Yuefeng Ji, and Daxiong Xu. "A Novel DBA Algorithm Supporting QoS for EPON Networks." In Asia Communications and Photonics Conference and Exhibition. Washington, D.C.: OSA, 2009. http://dx.doi.org/10.1364/acp.2009.tut6.

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Chen, Jiajia, Marilet De Andrade, Bjorn Skubic, Jawwad Ahmed, and Lena Wosinska. "Enhancing IPACT with limited service for multi-thread DBA in long-reach EPON." In 2010 Asia Communications and Photonics Conference and Exhibition (ACP 2010). IEEE, 2010. http://dx.doi.org/10.1109/acp.2010.5682661.

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Liu, Yang, Nan Ye, BaoJun Wang, DaiBing Zhou, JiaoQing Pang, LingJuan Zhao, and Wei Wang. "Monolithic integration of widely tunable sampled grating DBR laser with tilted semiconductor optical amplifier." In 2010 Asia Communications and Photonics Conference and Exhibition (ACP 2010). IEEE, 2010. http://dx.doi.org/10.1109/acp.2010.5682708.

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Ye, Nan, Yang Liu, BaoJun Wang, DaiBing Zhou, JiaoQing Pang, LingJuan Zhao, and Wei Wang. "Monolithic Integration of Widely Tunable Sampled Grating DBR Laser with Tilted Semiconductor Optical Amplifier." In Asia Communications and Photonics Conference and Exhibition. Washington, D.C.: OSA, 2010. http://dx.doi.org/10.1364/acp.2010.79870j.

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Skubic, Björn, Biao Chen, Jiajia Chen, Jawwad Ahmed, and Lena Wosinska. "Improved Scheme for Estimating T-CONT Bandwidth Demand in Status Reporting DBA for NG-PON." In Asia Communications and Photonics Conference and Exhibition. Washington, D.C.: OSA, 2009. http://dx.doi.org/10.1364/acp.2009.tut2.

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Gao, Guanjun, Jie Zhang, Wang Lei, and Wanyi Gu. "Analytical Results on the Performance of Coarse-Step DBP Based Intra-Channel Nonlinearity Compensators." In Asia Communications and Photonics Conference. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/acp.2013.af2f.67.

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Abeywickrama, Sandu, and Elaine Wong. "Single Receiver Dynamic Bandwidth Allocation (SR-DBA) Algorithm for Local Storage based VoD delivery." In Asia Communications and Photonics Conference. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/acp.2013.af3g.5.

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Tow Leong, Tiang, Mohd Saufi Ahmad, Ang Qian Yee, Syahrun Nizam Md Arshad@Hashim, Mohd Faizal Mohd Zahir, Mohd Azlizan Moh Adib, Nazril Husny, Tan Kheng Kwang, and Dahaman Ishak. HANDBOOK OF ELECTRICAL SYSTEM DESIGN FOR NON-DOMESTIC BUILDING. Penerbit Universiti Malaysia Perlis, 2023. http://dx.doi.org/10.58915/techrpt2023.001.

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This technical report presents the electrical system installation design for development of a factory with 1 storey and 2 storey of offices. Firstly, the general methodology of designing the electrical system are elaborated in this report. As overall, the methodologies in designing the components of the electrical system are explained and elaborated, which included: (a) load and maximum demand estimation; (b) miniature circuit breaker (MCB) selection; (c) moulded case circuit breaker (MCCB) selection; (d) air circuit breaker (ACB) selection, (e) residual current device (RCD) selection; (f) protection relay selection; (g) current transformer (CT) selection; (h) sizing selection for cable and live conductors; (i) capacitor bank selection for power factor correction (PFC); and (j) distribution transformer and its protection devices selection. Then, the electrical system of this project is computed and designed by using the methodologies aforementioned. Firstly, the electrical system of various distribution boards (DBs) with the protection/metering devices along with its phase and earthing cables for every final circuits are designed and installed in the factory. Next, the installation is proceeded with the electrical system of main switchboard (MSB) with the protection/metering devices along with its phase and earthing cables for every DBs. Also, the electrical system of PFC by using detuned capacitor bank with various protection/metering devices is designed and built in the plant. Apart from that, the factory is equipped with the electrical system of high tension (HT) room that included the distribution power transformer with the protection/metering devices along with its phase and earthing cables. Lastly, the methodologies and the computation design of the electrical system installation in the context of connected load, load currents, maximum demand, MCB, MCCB, ACB, RCD, protection relay, metering CTs, live cable, protection conductor/earth cable, detuned capacitor bank, and distribution transformer, are prepared according to several important standards, for instance, the MS IEC 60364, Electrical Installations for Buildings, Suruhanjaya Tenaga (ST) – Non-Domestic Electrical Installation Safety Code, Electricity Supply Application Handbook, Tenaga Nasional Berhad (TNB).

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