Статті в журналах з теми "ABAQUS 60.10"

In the present work, detailed studies were made on the transformation characteristics, microstructure and mechanical properties of heavy shell ring (HSR) in the spray cooling process. The spray cooling device of HSR was designed. The 2.25Cr1Mo0.25V steel used in production of HSR for hydrogenation reactor was selected as the testing material. The simulation of spray cooling of HSR was carried out on ABAQUS. The constitutive model and continuous cooling transformation (CCT) diagram of 2.25Cr1Mo0.25V were determined. CCT diagram, metallograph and SEM results show that the bainite forms throughout the cooling rate range from 0.5 to 10 ℃/s, and martensite begins to be produced by increasing the cooling rate higher than 60℃/s; when the cooling rate is 10 ℃/s, with the increase of the deformation degrees, the ferrite grain size becomes small, the yield strength and tensile strength increase, the elongation decrease, So it is good for refining the grain to increase the deformation. The yield strength, tensile strength and elongation were obtained under different cooling technology.

Concrete-filled steel tube (CFST) sections are structural members that effectively use the best properties of steel and concrete. Steel tube at the outer perimeter effectively resists tension and bending moments and also increases the stiffness of the section as steel has a high modulus of elasticity. The infilled concrete delays the local buckling of the thin outer steel tube. The interface bond strength plays a major role in the composite action of CFST sections. Provision of rectangular flutes on steel tube on CFST sections will improve the bond failure load and thereby the performance of CFST sections significantly. In this paper, the bond strength and displacement characteristics of steel-concrete composite sections are determined by incorporating rectangular shaped flutes into the steel tube. A total of five sections were tested to assess the influence of flutes on the bond strength. These tested sections are analyzed and are used to develop a finite element model using the finite element software ABAQUS version 6.13. The parameters chosen for the FE study are (i) type of flutes (outward and inward), (ii) D/t ratio (40, 60, and 80), (iii) number of flutes (2, 3, 4, 5, and 6), and (iv) dimension of flutes ((20 mm × 10 mm), (40 mm × 10 mm), and (60 mm × 10 mm)). Bond failure load is found to be higher for outward fluted sections compared to inward fluted and plain CFST sections.

In civil engineering an increasing demand for lightweight concretes exists, because a lower density results in significant benefits for structural elements. Polystyrene foams may be used in the fabrication of lightweight concretes with a large density range. In this work, the influence of fine grained sand (<1mm) additions of 5, 10 and 20% on the properties of a composite consisted of cement with styrofoam inclusions of 20, 40 and 60% has been studied. Finite element analysis (FEA), using Abaqus software package, was carried out to predict numerically the effect of particle size and polystyrene fraction on the compressive strength of the composite materials. The composites were characterized by their density, porosity and compressive strength after 28 days. The density of the composites varied between 1250 and 1600 kg/m3 with a strength of 18 and 9 MPa for 20 and 60% of Styrofoam inclusions, respectively. The increase of the fraction of sand from 5 to 20% promoted the increase in bulk density and modulus of the composites. The effect of the addition of sand on the porosity and mechanical strength exhibited variation indicating the packing factor of the particles as the main responsible for this behavior. Based on the finite element analysis the amount of the stress in the composite increases with the increasing particle diameter. The composites investigated exhibited a uniform distribution of the polystyrene spheres, allowing their use for non-structural purposes.

Flexible pipes, such as GRP pipes, serve as effective underground infrastructure especially as sewer pipeline. This study is an attempt for understanding the effects of bedding types on the behavior of large diameter GRP flexible sewer pipes using three dimensional finite element approaches. Theoretical and numerical analyses were performed using both BS EN 1295-1 approach and finite element method (ABAQUS software). The effects of different parameters are studied such as, depth of backfill, bedding compaction, and backfill compaction. Due to compaction, an increase in the bedding compaction modulus (E’1) results in a reduction of both stresses and displacements of the pipe, especially, for well compacted backfill. An increase of (E’1) from 14MPa to 30MPa results in a reduction in stresses 40% and about 25% in displacements. Maximum reductions in stresses were found to be about 25% only while the reduction in displacement was found to be less than 10%. As backfill material compaction modulus (E’2) is increased from 14MPa to 40MPa, a maximum reduction in stresses within the pipe was found to be not less than 60% while the displacement reduces up to 65%.

Geopolymer mortar is the best solution as an alternative to cement mortar in civil engineering. This paper deals with the effect of geopolymer mortar on the strength and microstructural properties under ambient curing conditions. In this research, geopolymer mortars were prepared with fly ash and steel slag (in the ratio 1:2.0, 1:2.5 and 1:3.0) as precursors with NaOH and Na2SiO3 as activator solution solutions (in the ratios of 0.5, 0.75 and 1.0) with concentrations of NaOH as 8 M, 10 M, 12 M and 14 M to study the compressive strength behaviour. From the experimental results, it was observed that the geopolymer mortar mix with the ratio of fly ash and steel slag 1:2.5, 12 M NaOH solution and the ratio of NaOH and Na2SiO3 0.5 exhibits the maximum compressive strength results in the range of 55 MPa to 60 MPa. From the optimized results, ferrocement panels of size 1000 mm × 1000 mm × 50 mm were developed to study the flexural behaviour. The experimental results of the flexural strength were compared with the analytical results developed through ABAQUS software. It was observed that the Trough-shaped geopolymer ferrocement panel exhibits 56% higher value in its ultimate strength than the analytical work. In addition to the strength properties, microstructural analysis was carried out in the form of SEM, EDAX and XRD from the tested samples.

In this article, a parametric study on the lateral-torsional buckling performance of thin-walled cold-formed steel Hybrid Double-I-Box Beams through numerical analyses has been presented. These built-up beams have distinctive cross-section geometry; the presence of more section modulus at the flanges provides high resistance to flexural bending and the closed-box portion offers high stiffness to resist torsion and lateral buckling. Therefore, these beams can be used for longer spans. The nonlinear finite element analysis was performed using ABAQUS software. All the beams were modelled as ideal finite element models adopting simply supported boundary conditions and loads were applied as end moments. To acquire a large number of data, three varying parameters were considered namely, hybrid parameter ratio, that is, yield strength of flange steel to web steel (1.0, 1.3, 1.5 and 1.7); ratio of breadth to depth of the beam (4/6, 5/6, 6/6 and 7/6); and length of the beam (1.0, 2.5, 5.0, 10, 15, 20, 30, 40, 50 and 60 in m). The thickness of both the flanges and the webs were 2.5 mm. All these parameters alter the overall slenderness of the members. It is shown that at larger spans, Hybrid Double-I-Box Beams experience lateral buckling. The results obtained from the numerical studies were plotted on nondimensional moment versus nondimensional slenderness graph. These results were compared with the predictions using effective width method design rules specified in Euro codes EN 3-1-3 and buckling curve-d of EN 3-1-1, which was originally adopted lateral-torsional buckling capacities of hot-rolled steel ‘I’ sections, and the adequacy is checked. It was found that Hybrid Double-I-Box Beams has higher lateral-torsional buckling capacity than common ‘I’ or box sections. Hence, a new simplified design equation was proposed for determining lateral-torsional buckling capacity of Hybrid Double-I-Box Beams.

FRP-confined concrete core-encased rebar (FCCC-R) is a novel composite structure that has recently been proposed to effectively delay the buckling of ordinary rebar and enhance its mechanical properties by utilizing high-strength mortar or concrete and an FRP strip to confine the core. The purpose of this study was to study the hysteretic behavior of FCCC-R specimens under cyclic loading. Different cyclic loading systems were applied to the specimens and the resulting test data were analyzed and compared, in addition to revealing the mechanism of elongation and mechanical properties of the specimens under the different loading systems. Furthermore, finite-element simulation was performed for different FCCC-Rs using the ABAQUS software. The finite-element model was also used for the expansion parameter studies to analyze the effects of different influencing factors, including the different winding layers, winding angles of the GFRP strips, and the rebar-position eccentricity, on the hysteretic properties of FCCC-R. The test result indicates that FCCC-R exhibits superior hysteretic properties in terms of maximum compressive bearing capacity, maximum strain value, fracture stress, and envelope area of the hysteresis loop when compared to ordinary rebar. The hysteretic performance of FCCC-R increases as the slenderness ratio is increased from 10.9 to 24.5 and the constraint diameter is increased from 30 mm to 50 mm, respectively. Under the two cyclic loading systems, the elongation of the FCCC-R specimens is greater than that of ordinary rebar specimens with the same slenderness ratio. For different slenderness ratios, the range of maximum elongation improvement is about 10% to 25%, though there is still a large discrepancy compared to the elongation of ordinary rebar under monotonic tension. Despite the maximum compressive bearing capacity of FCCC-R is improved under cyclic loading, the internal rebars are more prone to buckling. The results of the finite-element simulation are in good agreement with the experimental results. According to the study of expansion parameters, it is found that the hysteretic properties of FCCC-R increase as the number of winding layers (one, three, and five layers) and winding angles (30°, 45°, and 60°) in the GFRP strips increase, while they decrease as the rebar-position eccentricity (0.15, 0.22, and 0.30) increases.

Braided stents are commonly used to treat cerebral aneurysm, but there is little information about the bending characteristic of braided stent used for cerebral aneurysm. This paper investigates how geometrical parameters of braided stent influence its flexibility. Eight groups of braided stent models with different geometries (i.e., nominal diameter, length, braiding angle, number of wires, diameter of wire, frictional coefficient among wires and porosity) were constructed. Parametric analyses of these models were carried out by using Abaqus/Explicit. When the nominal diameter varied from 2[Formula: see text]mm to 5.5[Formula: see text]mm, the forces required for flexural deformation decrease from [Formula: see text][Formula: see text]N to [Formula: see text][Formula: see text]N; when the axial length varied from 10[Formula: see text]mm to 40[Formula: see text]mm, the forces required for flexural deformation decrease from [Formula: see text][Formula: see text]N to [Formula: see text][Formula: see text]N; when the braiding angle increases from 30[Formula: see text] to 75[Formula: see text] (the number of wires is 48 and the diameter of the wire is 0.026[Formula: see text]mm), the forces required for bending deformation decrease from [Formula: see text][Formula: see text]N to [Formula: see text][Formula: see text]N; when the diameter of wires increases from 0.026[Formula: see text]mm to 0.052[Formula: see text]mm (the number of wires is 24 and the braiding angle is 60[Formula: see text]), the forces required for flexural deformation increase from [Formula: see text][Formula: see text]N to [Formula: see text][Formula: see text]N; and when the number of wires increases from 14 to 48 (the braiding angle is 75[Formula: see text] and the diameter of the wire is 0.026[Formula: see text]mm), the forces required for flexural deformation increase from [Formula: see text][Formula: see text]N to [Formula: see text][Formula: see text]N. From the data above it can be seen that the diameter of wires, the number of wires and braiding angle have a larger impact on bending characteristics of braided stent; and the axial length and nominal diameter have a smaller impact on bending characteristics of braided stent. Results of the present study may provide theoretical guidance for the design of self-expanding braided stent and its clinical practice.

Multi-layer fabrics are commonly used in ballistics shields with a lower bulletproof class to protect against pistol and revolver bullets. In order to additionally limit the dynamic deflection of the samples, layers reinforced with additional materials, including non-Newtonian fluids compacted by shear, are additionally used. Performing a wide range of tests in each case can be very problematic; therefore, there are many calculation methods that allow, with better or worse results, mapping of the behavior of the material in the case of impact loads. The search for simplified methods is very important in order to simplify the complexity of numerical fabric models while maintaining the accuracy of the results obtained. In this article, multi-layer composites were tested. Two samples were included in the elements subjected to shelling. In the first sample, the outer layers consisted of aramid fabrics in a laminate with a thermoplastic polymer matrix. The middle layer contained a non-Newtonian shear-thickening fluid enclosed in hexagonal (honeycomb) cells. The fluid was produced using polypropylene glycol and colloidal silica powder with a diameter of 14 µm in the proportions of 60/40. The backing plate was made using a 12-layer composite made of Twaron® para-aramid fabrics with a DCPD matrix—not yet used in a wide range of ballistics. Then, numerical simulations were carried out in the Abaqus/Explicit dynamic analysis. The Johnson–Cook constitutive strength model was used to describe the behavior of elastic–plastic materials constituting the elements of the projectiles. For the non-Newtonian fluid, a Up-Us EOS was used. The inner layers of the fabric were treated as an orthotropic material. Complete homogenization of the sample layers was carried out, thanks to which each layer was treated as a homogeneous continuum. As a parameter of fracture mechanics for shield components, the strain criterion was used with the smooth particles hydrodynamics method (SPH). Then, the results of simulations were compared with the results of the ballistic test for both samples placed next to each other, which resulted in the formation of a multi-layer composite in one ballistic test subjected to impact loads during firing with a 9 × 19 mm Parabellum FMJ projectile with an initial velocity of 370 ± 10 m/s. The results of numerical tests are very similar to the ballistic tests, which indicates the correct mapping of the process and the correct conduct of layer homogenization. The applied proportions of the components in the non-Newtonian fluid allowed a reduction in the deflection compared to previous studies. Additionally, the proposal to use a DCPD matrix allowed to obtain a much lower deflection value compared to other materials, which is a novelty in the field of production of ballistic shields.

Thermal injuries are wide spread among home pets and are represented as a recent problem of veterinary medicine because of the lack of anti-burn drugs adapted for use in veterinary medicine. In this regard, the aim of our work is to certify the vulnerary spray “Acerbin” for medical purposes in the treatment of thermal injuries of animals and to evaluate its therapeutic potency according to the dynamics of healing burn injuries and recovery of the blood cell composition. The research was carried out on 60 laboratory white mice. Thermal injuries of the skin integument on the dorsal surface of the croup were simulated; the “Acerbin” spray was further applied. To achieve the aim, the blood samples and planimetric measured tests of the area of burn defects were taken on the 3rd, 5th, 7th, 10th and 14th day of treatment. The samples were analyzed by the quantitative content of erythrocytes, thrombocytes, leucocytes and cHb (blood hemoglobin concentration) using an automatic hematological analyzer “Abacus vet 10”. Planimetric indicators of the area of burns were subjected to mathematical processing with the calculation of the rate of epithelization of the burn injury. The obtained hematological and planimetric digital indicators were processed by statistical methods of analysis, compared and then interpreted.

During embryo development, embryonic gene activation (EGA) is the first critical event. We previously showed that EGA is also critical for further development in somatic cell-cloned embryos (Saeki K et al. 2004 Reprod. Fertil. Dev. 16, 157–158 abst). To show this, we reconstructed bovine embryos with bovine somatic cells transfected with chicken β-actin/firefly luciferase fusion gene (β−act/luc+) and showed that only luminescent embryos at 60 hours post-fusion (hpf) developed to the blastocyst stage. In this study, we examined the relation between the intensity of expression of the same reporter gene in embryos reconstructed with bovine β−act/luc+ fibroblasts and their subsequent development to the blastocyst stage. Bovine fibroblasts were transfected with β−act/luc+ as described earlier (Saeki K et al. 2004 Reprod. Fertil. Dev. 16, 157–158 abst). The stably transfected and cloned cells were cultured for several passages. The cells were cultured under serum starvation (0.4% FCS) for 7 days and then used as donor cells. In vitro-matured bovine oocytes derived from slaughterhouse ovaries were enucleated at 20 h post maturation. Enucleated oocytes were electrofused with the cells, and activated with a calcium ionophore and cycloheximide. The LUC+ signal (luminescence) in the embryos was detected in medium containing 500 μg mL−1 luciferin with an imaging photon counter (ARGUS 50, Hamamatsu, Japan) for 30 consecutive min at 60 hpf. The intensity of luminescence in embryos (4- to 8-cell stage) was graded as being strong (>10 × 104 pixels/embryo), intermediate (5 to 10 × 104 pixels/embryo), weak (<5 × 104 pixels/embryo), or absent. The embryos were cultured separately until 168 hpf, and examined for blastocyst development. Experiments were repeated four times, and the data were analyzed with Fisher's PLSD test following ANOVA by Stat View software (Ver. 5.0; abacus Concepts, Berkeley, CA, USA). Of 125 embryos that were reconstructed, 74 (59%) developed to the 4- to 8-cell stage at 60 hpf. The luminescence was strong in 29 (39%) of the embryos, intermediate in 12 (16%), weak in 19 (26%), and absent in 14 (19%). Blastocysts were obtained from a group of embryos that exhibited strong luminescence (10/29, 34%), but none of the embryos from the other groups developed to blastocysts. These results suggest that active gene expression in embryos reconstructed with somatic cells is important for their subsequent development. This study was supported by a Grant-in-Aid for the 21st Century COE Program of the Japan Ministry of Education, Culture, Sports, Science, and Technology, and by a grant from the Wakayama Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence of the JST.

Objetivo: Investigar os impactos na saúde e a reorganização do processo de trabalho dos Agentes Comunitários de Saúde (ACS) de uma Estratégia Saúde da Família no Município de Belém que atuaram no enfrentamento da pandemia da COVID-19. Métodos: Estudo de caso com abordagem quanti-qualitativa do tipo exploratória, com 10 ACS. Abordou-se o perfil sociodemográfico e o processo de trabalho, relação com o território, amigos e/ou familiares e aspecto emocional durante a pandemia de covid-19. A coleta de dados foi realizada por meio de entrevista semiestruturada. Os dados obtidos foram analisados com auxílio do software Excel e IramuteQ. Resultados: A amostra maioria feminina (80%), com idade média de 39 anos, ensino superior completo (40%). Destes 80% foram afastados por algum motivo durante a pandemia, todos realizaram teste para covid, dos quais 60% positivaram para Covid-19. Observou-se mudanças no processo de trabalho, uso considerável de tecnologias de comunicação social no cuidado, quanto a aspectos emocionais que apresentaram abalos devido medo, ansiedade e insônia. Conclusão: Conclui-se que a pandemia apesar de pontos positivos como a fortificação do uso de mídias sociais, causou danos emocionais aos agentes de saúde, repercutindo negativamente no bem-estar emocional.

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Abstract. The subject of this work is examination of API J55 steel casing pipes manufactured by high frequency (HF) contact welding. Since the pipes were withdrawn after about 70 000 hours of service in an oil drilling rig, the influence of the exploitation conditions on the material properties is determined. Experimental analysis includes tensile, impact toughness and fatigue testing of the specimens cut from the exploited pipe and the new pipe manufactured from the same-grade material. Additionally, pipe with flaws (stress concentrators) is tested by subjecting to internal pressure. The analysed stress concentrators represent defects which are often found in the exploitation: localized corrosion damages (corrosion pits). They were simulated by machining on the external surface of the pipe wall. The behavior of the pipes with these defects is determined by strain measurement and finite element analysis in software package Abaqus. The dimensions of the defects are varied, in order to determine the dependence of load carrying capacity on their depth and length. Several expressions from the literature are applied for estimation of the maximum pressure in damaged pipelines, and the solutions are compared with the predictions of finite element models. 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Background:The presence of cardiovascular disease in psoriatic arthritis (PsA) is of particular concern, as it is considered the leading cause of mortality in PsA. Thus, it is essential to recognize those appropriate therapies that could target this comorbidity, reducing the risk of cardiovascular disease and metabolic alterations.Objectives:To evaluate the efficacy of methotrexate (MTX) and apremilast as monotherapies or in combination, in the clinical manifestations of the disease and the reduction of cardiovascular risk factors in PsA.Methods:Prospective longitudinal study in 30 PsA patients diagnosed according to CASPAR criteria: 10 patients were treated with MTX (12 ± 2,58 mg/week), 10 patients with apremilast (60 mg/day) and 10 were treated with combined therapy for 6 months, recruited in the routine clinical practice at the Reina Sofia Hospital of Cordoba and University Hospital of Jaen, Spain. Clinical and analytical parameters were collected at baseline and after 6 months of treatment: lipid profile (cholesterol, HDL, LDL, TG, ApoA and ApoB), glucose and insulin, body surface area (BSA) affected by psoriasis, number of tender and swollen joints, DAS28, DAPSA, VAS, CRP and ESR.The presence of cardiometabolic risk factors such as metabolic syndrome (MetSyn) was evaluated according to National Cholesterol Education Program (NCEP) adult treatment panel III (ATP III) criteria, meeting 3 of the following characteristics: abdominal obesity (men (>102 cm); women (>88 cm), TG > 150 mg/dL, HDL (men (<40 mg/dL); women (<50 mg/dL), blood pressure > 130/85 mmHg, glucose levels > 110 mg/dL). Insulin resistance (HOMA-IR > 2,5), body mass index (BMI), ApoB/ApoA ratio, atherogenic index (AI) and SCORE (age, gender, cholesterol, HDL, smoking habit and diabetes) were also studied.Results:Apremilast or MTX monotherapies caused a moderate reduction of the clinical inflammatory markers (CRP and ESR) and disease activity (VAS, DAPSA and DAS28) after 6 months of treatment. On the other hand, while apremilast significantly reduced the affected BSA, MTX had no significant effect. All those parameters were more significantly reduced after the combined treatment (MTX+ apremilast).Apremilast monotherapy significantly improved alterations in the lipid profile (reducing cholesterol and LDL levels, ApoB/ApoA ratio and AI), insulin resistance and decreased BMI, thus reducing the number of patients with MetSyn. MTX monotherapy treatment had no positive effect on these parameters. None of the treatments had significant effects on SCORE values.The beneficial effects of apremilast on the lipid profile were mitigated after the combination with MTX. Nevertheless, the number of patients with MetSyn decreased even more after the combined therapy of MTX with apremilast compared to apremilast monotherapy.Conclusion:1) In patients with moderate disease activity, treatment with apremilast monotherapy might have some advantages compared to the MTX monotherapy, since it can decrease the percentage of BSA with psoriasis, the lipid profile alteration, IR and weight, thus improving the cardiovascular risk profile. 2) Combined therapy (MTX+ apremilast) can induce a deeper reduction in the disease activity compared to the monotherapies, maintaining, in turn, the positive effects of apremilast on the cardiovascular risk.Funded by ISCIII (PI17/01316 and RIER RD16/0012/0015) co-funded with FEDER.Disclosure of Interests:Nuria Barbarroja Puerto Grant/research support from: ROCHE and Pfizer., Speakers bureau: ROCHE and Celgene., Iván Arias de la Rosa: None declared, Carmen Torres-Granados: None declared, Maria del Carmen Abalos-Aguilera: None declared, Gómez García Ignacio: None declared, Isabel Añón Oñate: None declared, María José Pérez Galán: None declared, Desiree Ruiz: None declared, Alejandra M. Patiño-Trives: None declared, María Luque-Tévar: None declared, Eduardo Collantes Estevez Grant/research support from: ROCHE and Pfizer, Speakers bureau: ROCHE, Lilly, Bristol and Celgene, Chary Lopez-Pedrera Grant/research support from: ROCHE and Pfizer., Alejandro Escudero Contreras Grant/research support from: ROCHE and Pfizer, Speakers bureau: ROCHE, Lilly, Bristol and Celgene., María Dolores López Montilla Speakers bureau: Celgene

Background:Metotrexate (MTX) is the first-line treatment for rheumatoid arthritis (RA) both in monotherapy and in combination with biologic disease-modifying antirheumatic drugs (bDMARDs), it usually well tolerated but AEs may appear that causing toxicity that requires suspension of the treatmentObjectives:Determine the prevalence of certain polymorphisms among patients that receive bDMARD in monotherapy or in combination with MTX to confirm its relevance as biomarkers of intolerance. Evaluate the influence of certain polymorphisms in the effectiveness of monotherapy or combined treatment in patients, through“Disease Activity Score 28”(DAS28), SDAI Simple disease activity index (SDAI), Clinical disease activity index (CDAI) and each one of its componentsMethods:Retrospective observational multicentric study (University Hospital Complex, Granada, Carlos de Haya Hospital, Malaga and University Hospital Reina Sofia, Cordoba), of cases-control of 227 patients with RA (criteria ACR/EULAR), of which 120 received MTX and bDMARD combined therapy (cases) and other with only bDMARD (controls). All of them had been or were currently treated with MTX, remained with stable doses of bDMARD, and had a DNA sample stored before the inclusion in the studyDNA was isolated from total peripheral blood and by fluorescent probe HybProbe and/ or Taqman, 10 polymorphisms of 10 protein coding genes were determined involved in the metabolism and toxicity of MTX according to current evidenceBesides the type of polymorphism, data on the activity of the disease were analysed (DAS28VSG, DAS28PCR, SDAI, CDAI, at the start of the MTX income, of the BT, and in the inclusion visitA descriptive and comparative study was carried out on all that and afterwards an assessment was made through a multiple logistic regression analysis (MLR) on the risk of intolerance to MTXResults:An analysis was carried out on 227 patients (120 cases and 107 controls) with an average age of 60 (12,1) being women 78,4%, with a time of evolution since diagnosis of 14,84 (7,78) years48,9% registered adverse events (AE) MTX related, mainly gastrointestinal, hepatobiliary and skin-subcutaneous tissue. The percentage of AE appearance was superior in the monotherapy group than in the group with combined therapyThe most prevalent polymorphism (84,6% (IC95%: 84,09%-85,11%) and in cases (86,0% (IC95%: 79,43%-92,57%) washomozygous CC (ITPase-c94a); in controlshomozygous GG (GGH-T401C) (87,5% (IC95%:81,58%-93,42%)There were no significant differences in the parameters of activity between groups, in both, patients were best basally controlled than at the start of the MTX income and/or bDMARDBeinghomozygous-AA for the DHFR genewas significantly associated (p<0.05) with the appearance of AE (none of the 4 homozygous AA patients for that gene had AE)In MLR,homozygous GG(ref. heterozygous AG) in polymorphismGGH-T401C,beinghomozygous CC(ref. heterozygous TC) in polymorphismABCC2-C24TandPCR (mg/dL) at the start of bDMARDresulted independent predictive factors of MTX intoleranceConclusion:Polymorphisms T401C for the GGH gene and C24T for the ABCC2 gene and PCR at the start of the bDMARD resulted independent predictive factors of MTX intolerance. Polymorphismhomozygous AAforDHFR genewas related to significant protection against appearance of AEDisclosure of Interests:Alejandro Escudero Contreras: None declared, Rafaela Ortega Castro: None declared, Jerusalem Calvo Gutierrez: None declared, Natalia Mena-Vázquez: None declared, Rafael Cáliz Cáliz: None declared, Eduardo Collantes Estevez Grant/research support from: ROCHE and Pfizer, Speakers bureau: ROCHE, Lilly, Bristol and Celgene, Antonio Fernandez-Nebro: None declared, Maria del Carmen Abalos-Aguilera: None declared, Chary Lopez-Pedrera Grant/research support from: ROCHE and Pfizer., Mª Teresa Ruiz Jimenez Employee of: Roche Farma, SPAIN, Font Ugalde Pilar: None declared

<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:HyphenationZone>21</w:HyphenationZone> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>PT-BR</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val="--" /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; text-align: justify; mso-layout-grid-align: none; text-autospace: none;"><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; color: black;">Introdução: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; color: black;">O controle glicêmico na criança e no adolescente com diabetes melito tipo 1 (DM1) é influenciado por fatores como hábitos alimentares, prática de exercícios físicos, monitoração da glicemia capilar, insulinoterapia, interação familiar, condições socioeconômicas e aspectos emocionais vivenciados por esses indivíduos em seu processo saúde-doença. <strong>Objetivo: </strong>Revisão crítica da literatura sobre os fatores associados ao controle glicêmico em crianças e adolescentes com DM1. <strong>Metodologia: </strong>Foram pesquisados através dos bancos de dados MEDLINE/PubMed e LILACS-BIREME artigos científicos publicados nos últimos 10 anos que abordassem fatores modificadores do controle glicêmico em crianças e adolescentes com DM1. <strong>Resultados: </strong>Estudos mostram que indivíduos que aderiram ao plano alimentar, apresentaram redução média de 0,9% da HbA1c (hemoglobina glicada). Observou-se ainda diminuição significante nos níveis de HbA1c após adesão a um programa de atividade física regular, monitoração domiciliar da glicemia e uso de regimes intensivos de insulina. O envolvimento da família é um fator fundamental para adesão ao tratamento e controle glicêmico. Portadores do DM1 com menor nível socioeconômico e que vivenciam abalos emocionais apresentam um pior controle glicêmico. <strong>Conclusão: </strong>As evidências na literatura sugerem que os fatores mencionados na pesquisa estão intimamente ligados ao manejo do DM1. As informações mostram ainda que alterações desses aspectos conduz a criança e o adolescente a níveis de HbA1c acima do normal, levando-os assim a um controle glicêmico ruim/inadequado.</span></p> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; mso-layout-grid-align: none; text-autospace: none;"><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; color: black; mso-ansi-language: EN-US;" lang="EN-US"> </span></p> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; mso-layout-grid-align: none; text-autospace: none;"><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; color: black; mso-ansi-language: EN-US;" lang="EN-US">Abstract</span></strong></p> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; text-align: justify; mso-layout-grid-align: none; text-autospace: none;"><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; color: black; mso-ansi-language: EN-US;" lang="EN-US">Introduction</span></strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; color: black; mso-ansi-language: EN-US;" lang="EN-US">: The glycemic control in children and adolescents with type 1 diabetes mellitus (T1DM) is influenced by factors such as diet, physical exercise, blood glucose monitoring, insulin therapy, family interaction, socioeconomic and emotional aspects experienced by these individuals in their disease process. <strong>Objective</strong>: Critical review of the literature investigating factors associated with glycemic control in children and adolescents with T1DM. <strong>Methods</strong>: We searched through MEDLINE / PubMed and LILACS-BIREME databases, articles published in the last 10 years that addressed modifying factors of glycemic control in children and adolescents with DM1. <strong>Results</strong>: Studies demonstrate that individuals who adhered to the diet plan, showed an average reduction of 0.9% in HbA1c (glycated hemoglobin). There was also a significant reduction in HbA1c levels after adherence to a program of regular physical activity, home blood glucose monitoring and the use of intensive insulin regimens. Family involvement is a key factor in treatment adherence and glycemic control. T1DM patients with lower socioeconomic status and who experience emotional aftershocks have a poorer glycemic control. <strong>Conclusion</strong>: The evidence in the literature suggests that the factors mentioned in the research are closely linked to the management of T1DM. The information also show that changes in these aspects leads to children and adolescents with HbA1c levels above normal, thus leading them to a poor glycemic control inappropriate.</span></p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 4" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 5" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 6" /> 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Fractional derivative constitutive models, developed by the present authors (CND, vol.10, 061002, 2015), are implemented into a commercial finite element (FE) software, abaqus (referred to as a computational model) for solving dynamic problems of gel-like materials. This software is used to solve impact responses of gels, and the solutions are compared with the experimental results. The FE results reproduce well the experimental acceleration and displacement data from different types of gels whose properties are characterized by the fractional order and material parameters. Thus, the computational model presented here was validated. The fractional derivative model is compared with the Simo model (Computer Method in Applied Mechanics and Engineering, 60:153–173, 1987), which is an integer order derivative model. The response of the fractional derivative model can be approximated well when appropriate parameters of the Simo model are used. In the finite element method (FEM), compressibility is introduced artificially for simulations. Interpretations are given on the compressibility of materials in the FEM.

Tidal turbine infrastructure is currently in the large-scale prototype and short-term demonstration phase. However, the immediate requirement is to develop materials, processes and long-term life predictive facilities for tidal turbine plant that has decades of operational lifetime requirements. Computational modelling is a key tool to interpret the experimental data, understand the relevant mechanisms and provide a predictive capability for the performance of aged components for industries. The goal of this paper is a prediction of the long-term life of marine-based glass/epoxy and carbon/epoxy composite laminates aged in artificial seawater with 3.5% salinity based on Arrhenius degradation theory and tensile strength retention over 180 days ageing at room temperature and 60°C. Three different analytical models (linear and exponential) were implemented to calculate time shift factors and corresponding life in a real marine environment. Additionally, multi-scale modelling has been implemented via a representative volume element approach for square and hexagonal cells, and two-step homogenization of textile composites in accordance with nanoindentation testing for matrix/resin cells and fibre constraint cells after 90 days of immersion in saltwater. In general, the multi-scale modelling in ABAQUS and TexGen4SC was able to approximate (with about 10% difference) the mechanical properties of dry and aged composite laminates.

This paper presents finite element modeling of tapered fiber-reinforced polymer (FRP) poles in ABAQUS for dynamic analysis. Modal analysis and transient dynamic analysis are presented in order to evaluate the effect of fiber orientation, taper ratio, number of layers and lamina thickness on the dynamic properties of tapered poles. Trends observed from the parametric studies on the analyses of the FRP poles are enumerated. In addition, the effect of rectangular dynamic excitations on the overall response of the FRP poles is presented encapsulating impulsive loadings that may occur due to wind gusts or loss of cable tension supported by the FRP poles. Result shows that the fundamental frequency of the poles decreased as the fiber-orientation increased up to 60 degrees. In addition, the fundamental frequency of the poles increased as the number of layers increased. No significant difference was observed in natural frequency of the poles when varying the lamina thickness without changing the overall laminate thickness. The fundamental frequency of the FRP poles decreased by 10% as the taper ratio increased from 0.4 to 1. Transient dynamic analysis showed that FRP poles with higher fiber orientation angle had the larger maximum tip deflection. However, only small differences were observed when the deflections are normalized as the ratio of the maximum dynamic deformation to the maximum static deformation.

In previous in-situ measurements of metro trains it has been found that the velocity level on the track or tunnel wall may vary significantly between different train passages, even though the measuring section, the type of trains and the track and tunnel conditions are identical. An investigation is carried out into the sources of this variability, using a 3D train-track numerical model. This is built using the software SIMPACK and ABAQUS, and is connected through one-way coupling to a finite element model of the tunnel and soil. These models are used to study the influence of various train parameters, including the wheel and rail unevenness, train speed and degree of train loading. For comparison, in-situ measurements were made of the dynamic response of the rail and tunnel wall. The rail roughness at the site as well as the wheel unevenness of all 48 wheels for one train were measured. The results from the model indicate that the wheel unevenness affects the rail velocity level in the frequency region between 25 and 250 Hz and tunnel wall vibration above 5 Hz. The rail velocity level can vary by up to 20 dB due to wheel unevenness, with the largest variations occurring in the frequency bands 50–63 Hz. Variations in passenger loading affect the train-induced vibration by up to 4.5 dB, mainly in the low frequency region. When the train speed varies within a range of ±20% relative to the nominal speed 60 km/h, the frequencies of the peaks are shifted and the level in some frequency bands can change by as much as 10 dB. However, the largest influence is that of the wheel unevenness. It is concluded that the variation in these parameters, especially the wheel and rail unevenness, should be considered to achieve reliable predictions of train-induced vibration.

The safety analysis of important structure such as nuclear power plant against commercial aircraft has been studied. In the present study, a stepwise sequential analysis has been performed to determine the stresses on the nuclear containment wall under aircraft crash and induced fire effects. ABAQUS/Implicit finite element code was followed to get the response of the nuclear containment. First, the impact load is applied on the containment using Riera force history curve of Boeing 707-320, after 0.16 sec nodal temperatures were increased following the proposed jet fuel curve to imitate fire as a result of fuel burning. Combined effect of impact and heat has been used to study thermal stress variation. As the fuel is stored in the wings of the plane, the effect of fire is assumed to trigger as soon as the wings hit the outer face of containment wall. From Riera force history curve, time delay between plane’s first contact and wing contact with the containment wall was assumed to be 0.16 second. The effect due to fire was considered to be most severe at 10 m height from the base of containment structure. This is due to the fact that post-impact most of the fuel will immediately flow down to the bottom of containment. In the impact region, moderate fire for 15 minutes has been considered. The fire duration has been considered for 2 hrs at severe zone. The deformed geometry of model in impact analysis is then assumed to be the initial state for the thermal stress analysis. The concrete damaged plasticity model for concrete and JohnsonCook elastic-visco plastic material model for reinforcement have been taken to predict the behavior of concrete and steel. For heat transfer and thermal stress analysis, the material properties have been taken at elevated temperature form Eurocode 2. The containment has a circular cylindrical wall of inner diameter 42 m and thickness 0.85m excluding 6mm steel plate which was provided at the inner face of containment. The total height of the containment was assumed to be 60 m. The impact location of the aircraft was considered at the mid-height of the containment as more deformation was observed in this location

Background: Bistable composite laminates are emerging as smart structures in automotive and aerospace applications. However, the behavior of the wave propagation within such laminates has not been investigated, which hinders their implementation in structural health monitoring (SHM) and non-destructive evaluation (NDE). Objective: As a result, this manuscript examines the propagation behavior of guided waves in bistable composite structures. By understanding the effect of pre-stressing in bistable composite laminates on the characteristics of propagating waves, such as velocity and amplitude, a more knowledgeable decision about their applications in flaw detection and assessment can be made. Methods: The fundamental symmetric (S0) and anti-symmetric (A0) Lamb wave modes were investigated during propagation in two bistable composite laminates, [0/90]T and [02/902]T, and were assessed experimentally and numerically using ABAQUS. For the tested frequencies, which ranged from 60 kHz to 250 kHz, the behavior of the propagating wave was evaluated for both stable configurations and across two different actuators that were lined up with the fiber directions. Signal processing techniques were thus extensively used to enhance the measured signals and identify both the group velocities and the amplitudes’ trend of the S0 and A0 wave modes. Results: Our results showed that there is a minimal variation (typically below 1%) in the amplitude and velocity of the A0 and S0 modes when the composite plates switch between the first stable configuration and the second stable configuration in both composite plates. These results were numerically validated by replicating the bi-stability of the composites. The numerical data were in relatively close agreement (10% average error) with the experimental values and trends. Furthermore, the bistable effect was examined in detail relative to a reference numerical flat (monostable) plate. Although the bistable effect induced a notable amount of internal residual stress, this did not significantly impact the propagating wave modes, with a maximum difference of about 2% when comparing wave velocities. Conclusions: The effect on the wave propagation behavior along different directions of both stable configurations was shown to be minimal. These results, which were validated numerically, clear the ambiguity on the usage of these laminates in experimental health monitoring.

Abstract We present Abacus, a fast and accurate cosmological N-body code based on a new method for calculating the gravitational potential from a static multipole mesh. The method analytically separates the near- and far-field forces, reducing the former to direct 1/r2 summation and the latter to a discrete convolution over multipoles. The method achieves 70 million particle updates per second per node of the Summit supercomputer, while maintaining a median fractional force error of 10−5. We express the simulation time step as an event-driven “pipeline”, incorporating asynchronous events such as completion of co-processor work, Input/Output, and network communication. Abacus has been used to produce the largest suite of N-body simulations to date, the AbacusSummit suite of 60 trillion particles (Maksimova et al., 2021), incorporating on-the-fly halo finding. Abacus enables the production of mock catalogs of the volume and resolution required by the coming generation of cosmological surveys.

Abstract We present the public data release of the AbacusSummit cosmological N-body simulation suite, produced with the Abacus N-body code on the Summit supercomputer of the Oak Ridge Leadership Computing Facility. Abacus achieves $\mathcal {O}\left(10^{-5}\right)$ median fractional force error at superlative speeds, calculating 70M particle updates per second per node at early times, and 45M particle updates per second per node at late times. The simulation suite totals roughly 60 trillion particles, the core of which is a set of 139 simulations with particle mass 2 × 109 h−1 M⊙ in box size 2 h−1 Gpc. The suite spans 97 cosmological models, including Planck 2018, previous flagship simulation cosmologies, and a linear derivative and cosmic emulator grid. A sub-suite of 1883 boxes of size 500 h−1 Mpc is available for covariance estimation. AbacusSummit data products span 33 epochs from z = 8 to 0.1 and include lightcones, full particle snapshots, halo catalogs, and particle subsets sampled consistently across redshift. AbacusSummit is the largest high-accuracy cosmological N-body data set produced to date.