Статті в журналах: "843/.8"

1

Classen, Annika, Carolin Jakob, Melanie Stecher, David Tobys, Ellen Piepenbrock, Udo Holtick, Christof Scheid, Oliver Cornely, and Jörg Janne Vehreschild. "224. Epidemiology of Bloodstream infections in a Cohort of Allogeneic Hematopoietic Stem Cell Transplant Patients from 2009 to 2018." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S130. http://dx.doi.org/10.1093/ofid/ofz360.299.

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Abstract Background Due to severe immunosuppression, patients undergoing allogeneic hematopoietic stem cell transplantation (aSCT) are at increased risk of infection and especially bloodstream infections (BSI) remain a major cause of death. Knowledge of the specific epidemiology of pathogens and resistances is of utmost importance to optimize antimicrobial treatment strategies. Methods Based on the Cologne Cohort of Neutropenic Patients (CoCoNut) database, we conducted a retrospective analysis of blood cultures collected within 100 days following transplantation of patients undergoing aSCT between January 2009 and December 2018 at the University Hospital of Cologne, Germany. Contamination of coagulase-negative Staphylococci (CoNS) isolates (single positive isolate within 5 days) was considered within the analysis. Results In total, 843 aSCT patients were available for analysis (484/843 [57%] male). The median age was 53 (interquartile range [IQR] 43–62) years, predominant underlying diseases were acute myeloid leukemia (47%, 397/843), lymphoma (14%, 117/843), and acute lymphoblastic leukemia (11%, 89/843). Median inpatient stay was 39 (IQR 34–50) days, while 67/843 (8%) patients died. Antibacterial prophylaxis was administered in 289/843 (34%) and antifungal prophylaxis in 738/843 (88%) patients. BSI was diagnosed in 233/843 (28%) patients. In total, 5,489 pairs of blood cultures were taken (median 4 per patient, IQR 2–8), while a pathogen could only be detected in 922/5,489 (17%). Most frequent pathogens were CoNS (259/922, 28%), Enterococcus spp. (219/922, 24%), E. coli (132/922, 14%), Klebsiella spp. (44/922, 5%), P. aeruginosa (39/922, 4%), S. aureus (37/922, 4%), and Candida spp. (42/922, 5%). Polymicrobial infection was detected in 58/922 (6%) cases. Within Enterococci isolates, 24/219 (11%) were VRE. None of the Klebsiella, but 9/132 (7%) of E. coli isolates were ESBL positive. In 4/37 (11%) cases S. aureus isolates were MRSA. Conclusion Patients in the early phase after aSCT are at high risk of BSI with a predominantly gram-positive spectrum. Empirical antimicrobial treatment must consider pathogen epidemiology and resistance patterns while waiting for blood culture results. Disclosures All authors: No reported disclosures.

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Abdelhaleim, Manal S., Mehdi Rahimi, and Salah A. Okasha. "Assessment of drought tolerance indices in faba bean genotypes under different irrigation regimes." Open Life Sciences 17, no. 1 (January 1, 2022): 1462–72. http://dx.doi.org/10.1515/biol-2022-0520.

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Abstract Drought stress has devastating impacts on faba bean production, particularly with the current abrupt climate changes in arid environments. Hence, it is essential to identify drought-tolerant genotypes. The present study aimed at assessing six faba bean genotypes under three irrigation levels during two winter successive growing seasons (2018/2019 and 2019/2020). The applied irrigation levels were well-watered (every 4 days (D1), moderate drought every 8 days (D2), and severe drought 12 days (D3)) regimes. The analysis of variance exhibited highly significant differences among genotypes, irrigation treatments, and their interactions for all studied traits, except the number of pods plant−1 in the first season. Yield traits of all assessed genotypes decreased significantly with increasing drought stress. Otherwise, proline content (Pro) increased significantly with increasing drought stress. The genotypes Giza.843, Nubaria.2, and Nubaria.3 recorded the highest values of plant height, number of branches/plant, pods/plant, pods weight/plant, 100 seed weight, seed yield/plant, and seed yield/kg under drought stress. Similarly, the highest Pro was displayed by Giza.843 and Nubaria.3 under drought stress in both seasons. Furthermore, Giza.843, Nubaria.2, and Nubaria.3 genotypes had the highest values for most tolerant indices. Accordingly, these genotypes could be exploited in developing drought-tolerant and high-yielding faba bean genotypes in arid environments through breeding programs.

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3

Wu, JY, SG Shu, CF Yang, CC Lee, and FJ Tsai. "Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations." Journal of Endocrinology 172, no. 3 (March 1, 2002): 627–35. http://dx.doi.org/10.1677/joe.0.1720627.

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Total iodide organification defect (TIOD), where the iodide in the thyroid gland cannot be oxidized and/or bound to the protein, is caused by a defect in the thyroid peroxidase (TPO) gene. Single strand conformation polymorphism analysis was used to screen for mutations in the TPO gene from five unrelated TIOD patients in Taiwan, and five novel mutations were detected. Three of these were frameshift mutations: a single T insertion between nucleotide position 2268 and 2269 (c.2268-2269 insT) in exon 13 and two single C deletions at nucleotide positions 843 (c.843 delC) and 2413 (c.2413 delC) in exon 8 and 14 respectively. The other two were single nucleotide substitutions (c.G1477>A and c.G2386>T) located in exons 9 and 13 respectively. While the former would result in amino acid substitution (Gly493Ser) in the highly conserved region of the TPO polypeptide, the latter would result in either amino acid substitution (Asp796Tyr) or alternative splicing. Of those identified TPO mutations, c.2268-2269 insT was most prevalent and was detected as heterozygous in all but one TIOD patients. All five TIOD patients investigated in this study were compound heterozygous. The method presented in this study could be used for carrier assessment and mutation analysis of newly identified TIOD patients.

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4

Hankin, Cheryl S., Lorrin M. Koran, Amy Bronstone, Donald W. Black, David V. Sheehan, Eric Hollander, Jeffrey D. Dunn, et al. "Adequacy of Pharmacotherapy Among Medicaid-Enrolled Patients Newly Diagnosed with Obsessive-Compulsive Disorder." CNS Spectrums 14, no. 12 (December 2009): 695–703. http://dx.doi.org/10.1017/s1092852900023956.

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ABSTRACTObjective: To determine the adequacy of pharmacotherapy received by patients with newly-diagnosed obsessive-compulsive disorder (OCD), based on current practice guidelines.Methods: A 9 year (1997–2006) retrospective claims analysis of adults enrolled in Florida Medicaid for at least 3 continuous years was conducted to determine the percentage who received both a minimally effective duration (≥ 8 continuous weeks) and dose of first-line OCD pharmacotherapy during the year following their first (“index”) OCD diagnosis.Results: Among 2,960,421 adult (≥ 18 years of age) enrollees, 2,921 (0.1%) were diagnosed with OCD. Among the 2,825 OCD patients without comorbid Asperger syndrome or autism, 843 had newly-diagnosed OCD and at least 12 months of follow-up data after their index diagnosis. Among these 843 patients, 588 (69.7%) received first-line OCD pharmacotherapy but only 323 (38.3%) received a minimally effective pharmacotherapy trial in the year following their index diagnosis.Conclusions: Among clinically-diagnosed persons with OCD (<10% of those with the disorder), a minority of newly-diagnosed patients receive a minimally effective pharmacotherapy trial consistent with current standards of care. Reasons such as limited patient adherence and/or physician awareness of guidelines must be identified and redressed to ameliorate the patient, healthcare system, and economic burdens associated with OCD.

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Banerjee, A. K. "Emergencies in Clinical Radiology GrahamR GallagherF . 2009 (Oxford University Press, Oxford).pp. 423ISBN: 97-8-019923-843-9." British Journal of Radiology 83, no. 989 (May 2010): 450. http://dx.doi.org/10.1259/bjr-83-989-450a.

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6

Hunstead, R. W., D. Campbell-Wilson, and T. Ye. "The Radio Outburst from GRO J1655-40." Symposium - International Astronomical Union 165 (1996): 369–73. http://dx.doi.org/10.1017/s0074180900055832.

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Strong variable radio emission from the bright transient X-ray source GRO J1655-40 (X-ray Nova Scorpii 1994) has been detected at 843 MHz with the Molonglo Observatory Synthesis Telescope (MOST). As the hard X-ray intensity from the 1994 August outburst declined the radio output increased rapidly, reaching a peak of nearly 8 Jy some 12 days after the first X-ray peak. VLBI images obtained at this time showed two main components separating with an apparent transverse velocity > c. The evolution of the radio spectrum suggests that the time delay between X-ray and radio emissions is due, at least in part, to opacity effects associated with this expansion.

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7

Osipov, E. Y., T. V. Khodzher, L. P. Golobokova, N. A. Onischuk, V. Y. Lipenkov, A. A. Ekaykin, Y. A. Shibaev, and O. P. Osipova. "High-resolution 900 year volcanic and climatic record from the Vostok area, East Antarctica." Cryosphere 8, no. 3 (May 7, 2014): 843–51. http://dx.doi.org/10.5194/tc-8-843-2014.

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Abstract. Ion chromatography measurements of 1730 snow and firn samples obtained from three short cores and one pit in the Vostok station area, East Antarctica, allowed for the production of the combined volcanic record of the last 900 years (AD 1093–2010). The resolution of the record is 2–3 samples per accumulation year. In total, 24 volcanic events have been identified, including seven well-known low-latitude eruptions (Pinatubo 1991, Agung 1963, Krakatoa 1883, Tambora 1815, Huanaputina 1600, Kuwae 1452, El Chichon 1259) found in most of the polar ice cores. In comparison with three other East Antarctic volcanic records (South Pole, Plateau Remote and Dome C), the Vostok record contains more events within the last 900 years. The differences between the records may be explained by local glaciological conditions, volcanic detection methodology, and, probably, differences in atmospheric circulation patterns. The strongest volcanic signal (both in sulfate concentration and flux) was attributed to the AD 1452 Kuwae eruption, similar to the Plateau Remote and Talos Dome records. The average snow accumulation rate calculated between volcanic stratigraphic horizons for the period AD 1260–2010 is 20.9 mm H2O. Positive (+13%) anomalies of snow accumulation were found for AD 1661–1815 and AD 1992–2010, and negative (−12%) for AD 1260–1601. We hypothesized that the changes in snow accumulation are associated with regional peculiarities in atmospheric transport.

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8

朴, 长青, 媛. 杨 та 淑清葛. "电离辐射、骨髓移植及白血病发生的相关研究". Science in China Series B-Chemistry, Biological, Agricultural, Medical & Earth Sciences (in Chinese) 16, № 8 (1 серпня 1986): 843–49. http://dx.doi.org/10.1360/zb1986-16-8-843.

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9

谢, 益宽, та 文华肖. "外周神经损伤引起痛觉过敏的神经生理学机制". Science in China Series B-Chemistry, Life Sciences & Earth Sciences (in Chinese) 19, № 8 (1 серпня 1989): 843–51. http://dx.doi.org/10.1360/zb1989-19-8-843.

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10

陆, 全明, та 水. 王. "垂直无碰撞激波中质子的混沌运动和加热". Chinese Science Bulletin 42, № 8 (1 квітня 1997): 843–46. http://dx.doi.org/10.1360/csb1997-42-8-843.

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11

徐, 玖瑾, 若甫杜, 维东包, 苏玲朱 та 丽萍许. "中国10个人群中Y染色体Alu序列的多态分布". Chinese Science Bulletin 43, № 8 (1 квітня 1998): 843–46. http://dx.doi.org/10.1360/csb1998-43-8-843.

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12

吴, 福元, 成弼赵, 孝平路 та 艳斌张. "通化地区印支期花岗岩锆石U-Pb年龄及其与大别-苏鲁超高压带碰撞造山作用之间的关系". Chinese Science Bulletin 48, № 8 (1 квітня 2003): 843–49. http://dx.doi.org/10.1360/csb2003-48-8-843.

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13

余, 安喜, 也. 刘, 炬波朱, 歌实唐 та 甸农梁. "具有等式约束的滑动多项式建模方法". SCIENTIA SINICA Technologica 43, № 8 (1 серпня 2013): 843–49. http://dx.doi.org/10.1360/ze2013-43-8-843.

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樊, 世荣, та 兰翠姚. "边界条件对板壳稳定性的影响". Science in China Series A-Mathematics, Physics, Astronomy & Technological Science (in Chinese) 18, № 8 (1 серпня 1988): 843–50. http://dx.doi.org/10.1360/za1988-18-8-843.

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15

Gouné, M., A. Redjaïmia, T. Belmonte, and H. Michel. "Identification and characterization of a novel Mn–N nitride formed in Fe–Mn–N alloy." Journal of Applied Crystallography 36, no. 1 (January 21, 2003): 103–8. http://dx.doi.org/10.1107/s0021889802020101.

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An unexpected phase, formed throughout the ferritic matrix of an Fe–Mn (1.62 wt% Mn) alloy during a nitriding treatment at 843 K for 8 h, is analysed. This new phase, labelled θ′, is a metastable Mn nitride. It adopts the form of plates, with length 200 nm and width 20 nm. Its crystal structure is established by electron microdiffraction in conjunction with group-theory analysis. This nitride crystallizes in the tetragonal system and belongs to the space groupP 42/m 2/m 2/cwith the following lattice parameters: a_{\theta'} = 2.876 Å and c_{\theta'} = 5.752 Å. The θ′-phase crystal lattice is oriented with respect to the surrounding ferritic matrix according to the cube-on-cube orientation relationship, namely: (100)_{\theta'} || (200)_\alpha, (010)_{\theta'} || (020)_\alpha and (002)_{\theta'} || (002)_\alpha.

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16

Amy, SW, and MI Large. "A Simple Microstrip Phase Shifter." Australian Journal of Physics 45, no. 1 (1992): 105. http://dx.doi.org/10.1071/ph920105.

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A novel, inexpensive, series-connected loaded-line (SCOLL) phase shifter has been developed for the Molonglo Observatory Synthesis Telescope. The phase shifter, which operates at 0�843 GHz, consists of a ",3>'/8 length of microstrip with series connected varactors at each end. Although designed as a binary phase shifter, the insertion phase varies almost linearly with varactor reactance, with very little gain variation for phase ranges up to 90�. Thus, driven by a digital-to-analogue (D/ A) converter, a SCOLL becomes a programmable phase shifter of any desired resolution. The same technique would be suitable for narrow-band low power applications in the frequency range 0�1 to 10 GHz. This paper gives the basic theory of SCOLL phase shifters, a design chart, construction details and performance data.

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McSherry, Wilfred. "The Spiritual Dimension of Ageing by Elizabeth MacKinlay. Jessica Kingsley Publishers, London, 2001, 272 pages, f15.95, ISBN 1 843 10008 8." Journal of Advanced Nursing 38, no. 1 (April 2002): 106. http://dx.doi.org/10.1046/j.1365-2648.2002.2184d.x.

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18

Perczel-Forintos, Dóra, and Szilvia Kresznerits. "Szociális szorongás és önértékelés: a „Félelem a negatív megítéléstől” (FÉLNE) kérdőív hazai adaptációja." Orvosi Hetilap 158, no. 22 (June 2017): 843–50. http://dx.doi.org/10.1556/650.2017.30755.

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Abstract: Introduction: Although social anxiety disorder (SAD) is the third most frequent emotional disorder with 13–15% prevalence rate, it remains unrecognized very often. Social phobia is associated with low self-esteem, high self-criticism and fear of negative evaluation by others. It shows high comorbidity with depression, alcoholism, drug addiction and eating disorders. Aim: To adapt the widely used “Fear of Negative Evaluation” (FNE) social phobia questionnaire. Method: Anxiety and mood disorder patients (n = 255) completed the Fear of Negative Evaluation Scale (30, 12 and 8 item-versions) as well as social cognition, anxiety and self-esteem questionnaires. Results: All the three versions of the FNE have strong internal validity (α>0.83) and moderate significant correlation with low self-esteem, negative social cognitions and anxiety. The short 8-item BFNE-S has the strongest disciminative value in differentiating patients with social phobia and with other emotional disorders. Conclusions: The Hungarian version of the BFNE-S is an effective tool for the quick recognition of social phobia. Orv Hetil. 2017; 158(22): 843–850.

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JANIEC, J., M. R. EVANS, D. R. THOMAS, G. H. DAVIES, and H. LEWIS. "Laboratory-based surveillance ofCampylobacterandSalmonellainfection and the importance of denominator data." Epidemiology and Infection 140, no. 11 (January 5, 2012): 2045–52. http://dx.doi.org/10.1017/s0950268811002822.

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SUMMARYLaboratory data are the cornerstone in surveillance of infectious disease. We investigated whether changes in reported incidence ofCampylobacterandSalmonellainfection might be explained by changes in stool sampling rates. Data were extracted from a national database on 585 843 patient stool samples tested by microbiology laboratories in Wales between 1998 and 2008.Salmonellaincidence fell from 43 to 19 episodes/100 000 population butCampylobacterincidence after declining from 111/100 000 in 1998 to 84/100 000 in 2003 rose to 119/100 000 in 2008. The proportion of the population sampled rose from 2·0% in 1998 to 2·8% in 2008, mostly due to increases in samples from hospital patients and older adults. The proportion of positive samples declined for bothSalmonellaandCampylobacterfrom 3·1% to 1·1% and from 8·9% to 7·5%, respectively. The decline inSalmonellaincidence is so substantial that it is not masked even by increased stool sampling, but the recent rise inCampylobacterincidence may be a surveillance artefact largely due to the increase in stool sampling in older people.

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20

Lo, Shelly S., Lauren Allison Wiebe, Catherine Deamant, Amy Scheu, Betty Roggenkamp, Urjeet Patel, Pam Khosla, et al. "Supportive Oncology Collaborative: Initial impact of supportive oncology screening and care." Journal of Clinical Oncology 34, no. 26_suppl (October 9, 2016): 180. http://dx.doi.org/10.1200/jco.2016.34.26_suppl.180.

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180 Background: The Institute of Medicine (IOM) 2013 report recommends supportive oncology care from diagnosis through survivorship, to end of life. The Coleman Supportive Oncology Collaborative (CSOC) developed a city-wide plan to improve supportive oncology. Metrics derived from the Commission on Cancer (CoC), ASCO Quality Oncology Practice Initiative (ASCO-QOPI) and National Quality Forum (NQF) were used to assess the CSOC impact. Methods: Medical records of consecutive cancer patients from 6 practice improvement cancer centers in Chicago (3 academic, 2 safety-net, 1 public) were reviewed for 2 periods: 2014 (n = 843) and Q1 of 2015 (n = 313). Descriptive statistics assessed differences in quality metrics. Results: Significant improvement was achieved in 6 of 8 core supportive oncology metrics (see table). Conclusions: Consolidated metrics are feasible to assess supportive oncology quality. Early data indicate improvement and effectiveness of the collaborative approach. [Table: see text]

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Grandhi, Tarani S. P., Andreas Fontalis, Rhody D. Raj, Woo J. Kim, Dia E. Giebaly, and Fares S. Haddad. "Telehealth for a better service delivery in orthopaedic surgery." Bone & Joint Journal 105-B, no. 8 (August 1, 2023): 843–49. http://dx.doi.org/10.1302/0301-620x.105b8.bjj-2023-0089.r1.

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Telehealth has the potential to change the way we approach patient care. From virtual consenting to reducing carbon emissions, costs, and waiting times, it is a powerful tool in our clinical armamentarium. There is mounting evidence that remote diagnostic evaluation and decision-making have reached an acceptable level of accuracy and can safely be adopted in orthopaedic surgery. Furthermore, patients’ and surgeons’ satisfaction with virtual appointments are comparable to in-person consultations. Challenges to the widespread use of telehealth should, however, be acknowledged and include the cost of installation, training, maintenance, and accessibility. It is also vital that clinicians are conscious of the medicolegal and ethical considerations surrounding the medium and adhere strictly to the relevant data protection legislation and storage framework. It remains to be seen how organizations harness the full spectrum of the technology to facilitate effective patient care.Cite this article: Bone Joint J 2023;105-B(8):843–849.

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22

Stonkutė, Rima, and Vladas Vansevičius. "Subaru Suprime-Cam Wide-field BVI Stellar Photometry of the M33 Galaxy." Astrophysical Journal Supplement Series 273, no. 2 (July 24, 2024): 22. http://dx.doi.org/10.3847/1538-4365/ad566e.

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Abstract We have surveyed the complete extent of the disk of M33—a gas-rich low-mass dwarf spiral galaxy in the Local Group. The B-, V-, and I-passband (the Johnson–Cousins system) CCD images (typical seeing ∼0.″8) were obtained with the Subaru Telescope equipped with the Suprime-Cam mosaic camera. The wide-field (∼1.°0 × 1.°5) catalog of 803,095 (15 ≤ V ≤ 25) starlike objects, measured using the point-spread function and aperture photometry techniques, is presented. We determined the distance modulus of M33 using the tip of the red giant branch (I TRGB = 20.64 ± 0.02) as a reference point of (m − M)0 = 24.63 ± 0.02stat ± 0.06syst (843 kpc). We found young (≲100 Myr) stellar populations residing up to the deprojected radius of ∼10 kpc. The scale length of the young main-sequence (MS) star surface-number density in the range of radial distances from 7 to 9 kpc is 0.53 ± 0.03 kpc. The youngest MS stars (≲15 Myr) reside up to the radius of ∼8 kpc. This distribution of stellar populations may suggest an outside-in scenario of recent star formation in the disk of M33.

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23

Togabayeva, Guldana. "Regarding the Celebration of the Seventieth Birthday of Mária Ivanics." Golden Horde Review 8, no. 4 (December 29, 2020): 838–43. http://dx.doi.org/10.22378/2313-6197.2020-8-4.838-843.

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The seventieth birthday commemoration of the outstanding representative of Hungarian Turkic studies, Professor Mária Ivanics, was held 11 September 2020, at 11 a.m., in the Faculty of Humanities and Social Sciences building at the University of Szeged in Hungary. Professor Ivanics’s many friends, colleagues, and students gathered to congratulate her and pay tribute to her professional achievements. The Vice Dean of the faculty, Klára Sándor, Academician András Róna-Tas (in absentia), Professor Sándor Papp, and Professor István Zimonyi spoke in honor of Professor Ivanics. Among these presenters, Professor István Zimonyi, the head of the Department of Altaic Studies and the Department of Medieval History, spoke on behalf of the former department about Ivanics’ academic career and presented the volume Ottomans–Crimea–Jochids: Studies in Honour of Mária Ivanics, in which leading Hungarian and foreign scholars and young researchers published papers dedicated to her. This Festschrift presents various aspects of the development of Turkic culture and languages, TurkicHungarian relations (including Ottoman-Hungarian relations), as well as the history and culture of the Ottoman Empire and the Golden Horde. It contains 29 works by scholars from universities in Germany, Russia, Turkey, Kazakhstan, and Hungary. The collected articles are presented in five languages – English, German, Russian, Hungarian, and Turkish.

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24

Harousseau, Jean-Luc, Giovanni Martinelli, Wieslaw W. Jedrzejczak, Joseph M. Brandwein, Dominique Bordessoule, Tamas Masszi, Gert J. Ossenkoppele, et al. "A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older." Blood 114, no. 6 (August 6, 2009): 1166–73. http://dx.doi.org/10.1182/blood-2009-01-198093.

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AbstractThis phase 3, multicenter, open-label study evaluated the efficacy and safety of tipifarnib compared with best supportive care (BSC), including hydroxyurea, as first-line therapy in elderly patients (≥70 years) with newly diagnosed, de novo, or secondary acute myeloid leukemia. A total of 457 patients were enrolled with 24% 80 years of age or older. Tipifarnib 600 mg orally twice a day was administered for the first 21 consecutive days, in 28-day cycles. The primary endpoint was overall survival. The median survival was 107 days for the tipifarnib arm and 109 days for the BSC arm. The hazard ratio (tipifarnib vs BSC) for overall survival was 1.02 (P value by stratified log-rank test, .843). The complete response rate for tipifarnib in this study (8%) was lower than that observed previously, but with a similar median duration of 8 months. The most frequent grade 3 or 4 adverse events were cytopenias in both arms, slightly more infections (39% vs 33%), and febrile neutropenia (16% vs 10%) seen in the tipifarnib arm. The results of this randomized study showed that tipifarnib treatment did not result in an increased survival compared with BSC, including hydroxyurea. This trial was registered at www.clinicaltrials.gov as #NCT00093990.

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25

Çğalar, Sena, and Aysel Öztun. "A Sensitive Spectrophotometric Method for the Determination of Desloratadine in Tablets." Journal of AOAC INTERNATIONAL 90, no. 2 (March 1, 2007): 372–75. http://dx.doi.org/10.1093/jaoac/90.2.372.

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Abstract A simple, rapid, and sensitive visible spectrophotometric method was developed, for the first time, for analysis of desloratadine (DE) in tablets. The method is based on the deep-blue colored TCNQ- radical anion formed by interaction of the drug (n-donor) with 7,7,8,8-tetracyanoquinodimethane (TCNQ, π-acceptor) in acetonitrile at ambient temperature. Optimum conditions for the reaction were investigated, absorbances were read at 843 nm, and the linearity range for concentrations of DE was found to be 1.5-13 μg/mL. The reaction product remains stable up to 8 h when kept at room temperature in the dark. The developed method was validated and successfully applied to the determination of DE in tablets. The tablets were also analyzed with a column liquid chromatography method reported in literature. The results from both methods were statistically compared by t- and F-tests. No significant difference was found for the means and standard deviations at 95% confidence level. Accuracy was examined through recovery studies. Being very simple and reliable, the method can be recommended for routine quality control analysis of DE in tablets.

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26

Ojha, BR. "Comparison of Eco-Mse and Pst-Mse Primer Combinations in Generating AFLP Map of Tomato." Journal of the Institute of Agriculture and Animal Science 26 (April 1, 2005): 27–35. http://dx.doi.org/10.3126/jiaas.v26i0.608.

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An experiment was conducted at Wageningen University and Research Centre (WUR), Unifarm, Haarweg, Wageningen, The Netherlands in 2000 to compare Eco-Mse and Pst-Mse primer combinations to generate AFLP markers of tomato. Back cross first (BC1) population ofLycopersicon esculentum cv money maker and Lycopersicon pennellii LA716 was used. Six primer combinations (three of Eco-Mse and three of Pst-Mse) were used. A total of 122 AFLP markers were found generating 76 markers by Eco-Mse primer combination and 46 markers by Pst-Mse primer combination. The average number of informative markers per primer combination was 20.33 ranging from 11 (P11M50) to 36 (E35M48). Similarly the average number of informative markers per chromosome was 10.16 ranging from 4 (chromosome number 8) to 16 (chromosome number 1). Within Eco-Mse primer combinations, E32M50 generated the least (18) and E35M48 generated the highest (36) AFLP markers. Similarly, within Pst-Mse primer combination, P14M50 generated the highest (20) and P11M50 generated the least (11) AFLP markers. The Eco-Mse primer combination generated the highest number of marker (12) in chromosome 9 and the lowest (2) in chromosome number 8. Similarly, the Pst-Mse primer combination generated the highest number of markers (9) in chromosome number 1 and the lowest (2) in chromosome number 3, 8, 11 and 12. The AFLP map spanned 843 cM. The longest AFLP map was found in chromosome 1 and spanned 98 cM and the shortest in chromosome 8 and spanned 46 cM. Key words: Tomato, Back cross, Primer combination, AFLP map J. Inst. Agric. Anim. Sci. 26:27-35 (2005)

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Suprun, I. I., S. A. Plugatar, I. V. Stepanov, and T. S. Naumenko. "Analysis of genetic relationships of genotypes of the genus Rosa L. from the collection of Nikita Botanical Gardens using ISSR and IRAP DNA markers." Vavilov Journal of Genetics and Breeding 24, no. 5 (August 28, 2020): 474–80. http://dx.doi.org/10.18699/vj20.639.

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In connection with the development of breeding and the creation of new plant varieties, the problem of their genotyping and identification is becoming increasingly important, therefore the use of molecular methods to identify genetic originality and assess plant genetic diversity appears to be relevant. As part of the work performed, informative ISSR and IRAP DNA markers promising for the study of genetic diversity of the Rosa L. genus were sought and applied to analysis of genetic relationships among 26 accessions of the genus Rosa L. from the gene pool collection of Nikita Botanical Gardens. They included 18 cultivated varieties and 8 accessions of wild species. The species sample included representatives of two subgenera, Rosa and Platyrhodon. The subgenus Platyrhodon was represented by one accession of the species R. roxburghii Tratt. Cultivated roses were represented by varieties of garden groups hybrid tea, floribunda, and grandiflora. The tested markers included 32 ISSRs and 13 IRAPs. Five ISSR markers (UBC 824, ASSR29, 3A21, UBC 864, and UBC 843) and three IRAPs (TDK 2R, Сass1, and Сass2) were chosen as the most promising. They were used for genotyping the studied sample of genotypes. In general, they appeared to be suitable for further use in studying the genetic diversity of the genus Rosa L. The numbers of polymorphic fragments ranged from 12 to 31, averaging 19.25 fragments per marker. For markers UBC 864 and UBC 843, unique fingerprints were identified in each accession studied. The genetic relationships of the studied species and varieties of roses analyzed by the UPGMA, PCoA, and Bayesian methods performed on the basis of IRAP and ISSR genotyping are consistent with their taxonomic positions. The genotype of the species R. roxburghii of the subgenus Platyrhodon was determined genetically as the most distant. According to clustering methods, the representative of the species R. bengalensis did not stand out from the group of cultivated varieties. When assessing the level of genetic similarity among the cultivated varieties of garden roses, the most genetically isolated varieties were ‘Flamingo’, ‘Queen Elizabeth’, and ‘Kordes Sondermeldung’; for most of the other varieties, groups of the greatest genetic similarity were identified. This assessment reflects general trends in phylogenetic relationships, both among the studied species of the genus and among cultivated varieties.

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Bartkowiak, Sylwia, Jan M. Konarski, Ryszard Strzelczyk, Jarosław Janowski, Małgorzata Karpowicz, Vitor P. Lopes, and Robert M. Malina. "WEIGHT STATUS, BMI AND PHYSICAL FITNESS IN POLISH YOUTH: RELATIONSHIPS BETWEEN 1986 AND 2016." Acta kinesiologica, N2 2021 (2021): 134–43. http://dx.doi.org/10.51371/issn.1840-2976.2021.15.2.18.

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Background: One of the components affecting the level of health is physical fitness and diets, which is also considered the foundation of a healthy lifestyle. Methods: Samples by survey ranged from 871 to 1,417 (boys) and from 843 to 1,326 (girls). Speed (5 m run), agility (figure-8-run), explosive power (vertical jump), flexibility (stand and reach) and cardiovascular fitness (step test) were measured. The Body Mass Index (BMI) of each student was classified as Thin, Normal weight or Overweight/Obese (Owt/Ob) relative to International Obesity Task Force (IOTF) criteria. Fitness items were compared among weight status groups and across surveys with sex-specific analyses of covariance. Regressions of each fitness item on the BMI in the four surveys were done using linear and nonlinear quadratic models. Results: Performances on all fitness tests except flexibility were poorer among Owt/Ob compared to Normal and Thin youth, but performances on fitness tests within weight status groups did not differ consistently across surveys. Conclusions: Relationships between the BMI and fitness tests varied across surveys, but suggested reasonably consistent cur-vilinear relationships between fitness tests and the BMI among boys more so than girls.

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Ellanti, Prasad, Breda Cushen, Adam Galbraith, Louise Brent, Conor Hurson, and Emer Ahern. "Improving Hip Fracture Care in Ireland: A Preliminary Report of the Irish Hip Fracture Database." Journal of Osteoporosis 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/656357.

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Introduction. Hip fractures are common injuries in the older persons, with significant associated morbidity and mortality. The Irish Hip Fracture Database (IHFD) was implemented to monitor standards of care against international standards.Methods. The IHFD is a clinically led web-based audit. We summarize the data collected on hip fractures from April 2012 to March 2013 from 8 centres.Results. There were 843 patients with the majority being (70%) female. The 80–89-year age group accounted for the majority of fractures (44%). Most (71%) sustained a fall at home. Intertrochanteric fractures (40%) were most common. Only 28% were admitted to an orthopaedic ward within 4 hours. The majority (97%) underwent surgery with 44% having surgery within 36 hours. Medical optimization (35%) and lack of theatre space (26%) accounted for most of the surgical delay. While 29% were discharged home, 33% were discharged to a nursing home or other long-stay facilities. There was a 4% in-hospital mortality rate.Conclusions. Several key areas in both the database and aspects of patient care needing improvement have been highlighted. The implementation of similar databases has led to improved hip fracture care in other countries and we believe this can be replicated in Ireland.

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Ekasari, Andini, Liana Rahardja, Imam Hidayat, and Juli Anwar. "Governance Ethics: Bibliometric VOSviewer Analysis and Future Research Opportunities." International Journal of Digital Entrepreneurship and Business 5, no. 1 (June 10, 2024): 16–28. http://dx.doi.org/10.52238/ideb.v5i1.155.

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This study aimed to conduct a bibliometric analysis to map Scopus-indexed scientific publications on Governance Ethics. The Publishing or Perish software collected Research data using the “governance ethic” keyword. This data was then processed using a VOS viewer to analyze and visualize the number of publications, researchers, keywords, and future research opportunities. The results revealed 499 scientific articles on governance and ethics, with the highest number published in 2021, totaling 42 articles. The earliest publication dates to 1982 by T. Purcell from Georgetown University, Washington, D.C., United States. The most prolific journal of publications is the Journal of Business Ethics, published by Springer Netherlands. Among researchers, Sison and Alejo Jose G. from Spain emerged as the most productive, with 8 publications and an H-index of 17. Sison is affiliated with the University of De Navarra, Pamplona, Spain. 926 authors were filtered down to 93, forming 10 networks and 2 clusters. Regarding keywords, 843 were filtered down to 138, with the most common being ethics, governance, business ethics, research ethics, and corporate social responsibility. The theoretical implication of this study lies in its utilization of bibliometric analysis for mapping governance ethics in Scopus-indexed scientific publications.

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Kong, Xiangmudong, Wenqiang Sun, Jin Zhang, and xinbin Chen. "Abstract 843: Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73gamma in tumorigenesis and obesity via leptin." Cancer Research 82, no. 12_Supplement (June 15, 2022): 843. http://dx.doi.org/10.1158/1538-7445.am2022-843.

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Abstract TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-terminal isoforms (α-η). Interestingly, TAp73 is shown to have opposing functions in tumorigenesis but the mechanism remains unclear. Here, we showed that deletion of exon 11 (E11) switches p73α to p73γ, the latter of which has oncogenic activities. Moreover, E11-deficient mice phenocopies Trp73-deficient mice with short lifespan, infertility, chronic inflammation and tumor incidence, indicating that p73γ cannot compensate p73α for tumor suppression and fertility. E11-deficient mice were also prone to obesity and B-cell lymphomas, indicating a unique role of p73γ in lipid metabolism and tumorigenesis. Mechanistically, we showed that Leptin, a pleiotropic adipocytokine, was highly induced by p73γ and necessary for p73γ-mediated oncogenic activity. Importantly, p73α-γ isoform switch was detected in dog lymphomas and human prostate carcinomas along with elevated expression of Leptin. Our study indicates that the p73γ-Leptin pathway promotes tumorigenesis and alters lipid metabolism. Citation Format: Xiangmudong Kong, Wenqiang Sun, Jin Zhang, xinbin Chen. Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73gamma in tumorigenesis and obesity via leptin [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 843.

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Pate, Christopher L., and Joyce E. Turner-Ferrier. "Exploring Linkages between Quality, E-Health and Healthcare Education." International Journal of Healthcare Delivery Reform Initiatives 2, no. 4 (October 2010): 66–81. http://dx.doi.org/10.4018/978-1-61692-843-8.ch013.

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This chapter explores the concept of e-health as it relates to healthcare delivery, healthcare quality and education. Although the concept of e-health is emerging and lacks clear definition, a body of literature in healthcare policy and organization has focused on many of themes and ideas that are relevant to the study of e-health. This chapter introduces several frameworks and concepts that are essential for an inquiry into the relationships between e-health and quality-related outcomes in healthcare and educational settings. This chapter addresses these relationships by discussing and defining the concept of e-health, discussing central linkages between e-health and quality-related healthcare outcomes, and highlighting key themes between health education, technology and quality.

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Bartkowiak, Sylwia, Jan M. Konarski, Ryszard Strzelczyk, Jarosław Janowski, Małgorzata Karpowicz, and Robert M. Malina. "Physical Fitness of Rural Polish School Youth: Trends Between 1986 and 2016." Journal of Physical Activity and Health 18, no. 7 (July 1, 2021): 789–800. http://dx.doi.org/10.1123/jpah.2020-0712.

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Background: The objective of the study was to evaluate secular changes in the physical fitness of rural school youth, 7–15 years, in west-central Poland between 1986 and 2016. Methods: The fitness of cross-sectional samples of school youth resident in the same 10 communities was evaluated in 4 decennial surveys: 1986—1417 boys/1326 girls; 1996—979 boys/947 girls; 2006—871 boys/843 girls; and 2016—1189 boys/1105 girls. Five tests evaluated speed (5-m run), agility (figure 8 run), explosive power (vertical jump), flexibility (stand and reach), and cardiovascular fitness (modified Harvard step test). Age- and sex-specific descriptive statistics were calculated by survey, while differences among surveys were compared in 3 broad age groups (7–9, 10–12, and 13–15 y) using analysis of variance with age and age squared as covariates. Results: Speed and flexibility declined, while the jump and step test index changed variably across surveys. Although agility improved across surveys, the major improvement occurred between 1986 and 1996. Conclusions: Performances of rural school youth on 5 tests of physical fitness changed significantly, but, variably, between 1986 and 2016. The results were generally consistent with other studies of Polish school youth that spanned a similar interval.

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Zorić, Marina, Ivan Varnica, Goran Jukić, and Ružica Jurić. "Priznavanje sorti u Republici Hrvatskoj." Sjemenarstvo 31, no. 1-2 (January 30, 2021): 41–52. http://dx.doi.org/10.33128/s1.31.1-2.5.

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Priznavanje sorti poljoprivrednog bilja u Republici Hrvatskoj provodi se u Hrvatskoj Agenciji za poljoprivredu i hranu - Centru za sjemenarstvo i rasadničarstvo u skladu sa Zakonom o sjemenu, sadnom materijalu i priznavanju sorti poljoprivrednog bilja (NN 140/05, 35/08, 25/09, 124/10, 55/11 i 14/14), Pravilnikom o upisu sorti u Sortnu listu (NN 45/08, 84/08, 77/13, 136/15, 57/17, 70/18 i 75/19), Pravilnikom o priznavanju sorti poljoprivrednog bilja (NN 99/08, 100/09, 109/10, 77/13 i 57/18) i Pravilnikom o postupku utvrđivanja različitosti, ujednačenosti i postojanosti novih biljnih sorti u svrhu dodjeljivanja oplemenjivačkog prava i priznavanja sorti (NN 61/11). Sortna lista Republike Hrvatske je službeni popis sorti vrsta bilja koje su priznate u Republici Hrvatskoj. Postupkom priznavanja sorte stječe se pravo upisa sorte u Sortnu listu Republike Hrvatske, Zajedničku sortnu listu Zajednice i OECD listu. Trenutno je na Sortnoj listi Republike Hrvatske upisano 843 sorti poljoprivrednog bilja i povrća. Od osnivanja Centra za sjemenarstvo i rasadničarstvo (1998.) do danas je zaprimljeno 4.181 zahtjev za priznavanje za 103 biljne vrste. Od tog su broja priznate 2.409 sorti, 1.251 je povučeno iz ispitivanja, a 285 sorti nisu priznate. Za 8 sorti je odbačen zahtjev za priznavanje i 228 sorti se nalazi u postupku ispitivanja.

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Tumedei, Margherita, Carlos Fernando Mourão, Silvia D’Agostino, Marco Dolci, Michele Di Cosola, Adriano Piattelli, and Alessandra Lucchese. "Histological and Histomorphometric Effectiveness of the Barrier Membranes for Jawbone Regeneration: An Overview of More Than 30 Years’ Experience of Research Results of the Italian Implant Retrieval Center (1988–2020)." Applied Sciences 11, no. 5 (March 9, 2021): 2438. http://dx.doi.org/10.3390/app11052438.

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With the advent of implant dentistry, height and width of the bone site are fundamental to perform implant placements. There are several techniques to restore the amount of bone loss and one of them is guided bone regeneration, which is based on the employment of a membrane in order to bypass non-osteogenic cell invasion in the bone healing area, dispersing every interference with bone regeneration. Two expert reviewers performed a retrospective evaluation of all scientific papers published by the Implant Retrieval Center Laboratory of University “G. D’Annunzio” of Chieti-Pescara in the last three decades, and they implemented it by also similar conducting research on the main scientific databases, i.e., PubMed, Scopus, and EMBASE. The search was conducted up to December 2020, and a total of 843 articles published by the Implant Retrieval Center Laboratory of University “G.D’Annunzio” of Chieti-Pescara were identified and evaluated. After the application of inclusion and exclusion criteria, a total of 27 manuscripts were included for the qualitative synthesis: 8 animal studies, 17 human studies, and 2 in vitro articles. The present overview shows the importance of translational research for barrier membranes for bone regeneration, and additionally, the need for experts in different fields and research centers to produce high quality data in future research.

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Carrillo-González, Diego F., Nélida Rodríguez-Osorio, Charles R. Long, Neil A. Vásquez-Araque, and Juan G. Maldonado-Estrada. "l-Carnitine Supplementation during In Vitro Maturation and In Vitro Culture Does not Affect the Survival Rates after Vitrification and Warming but Alters Inf-T and ptgs2 Gene Expression." International Journal of Molecular Sciences 21, no. 16 (August 5, 2020): 5601. http://dx.doi.org/10.3390/ijms21165601.

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l-carnitine is a potent antioxidant used for in vitro culture systems. Controversial results have been reported using l-carnitine in culture medium at different stages of in vitro bovine embryo production. Cumulus-oocyte complexes (n = 843) were in vitro-fertilized and cultured and added (treatment group) or not added (control group) with l-carnitine. At day three of culture, each group was subdivided into two subgroups receiving no l-carnitine (group 1), 3.8 mM l-carnitine added during in vitro maturation (group 2), 1.5 mM added during the in vitro culture (group 3), and 3.8 mM and 1.5 mM added during the maturation and culture, respectively (group 4). At day 8, blastocyst embryos were examined for mitochondrial activity, the presence of lipid droplets, total cell number, gene expression, and cryotolerance by vitrification. The data were analyzed with a one-way analysis of variance. l-carnitine added in the late in vitro culture significantly reduced mitochondrial activity and lipid content, and upregulated ifn-τ and ptgs2 gene expression compared to controls (p < 0.05). l-carnitine supplementation did not significantly affect the embryo rate production or survival rate after vitrification and warming (p > 0.05). l-carnitine supplementation significantly improved embryo potential to develop viable pregnancies in agreement with a study reporting improved pregnancy rates.

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Aznar, Francisco Javier, José Monterde-López, Samuel Aunión-Díaz, Harry J. Lehto, and Elena Circella. "First evidence of avian pox-like outbreaks in Eurasian coots, Fulica atra, from Europe: A widespread phenomenon?" Avian Biology Research 12, no. 4 (July 1, 2019): 139–44. http://dx.doi.org/10.1177/1758155919860349.

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Avian pox is a disease caused by Avipoxvirus spp. that is known to produce self-limiting, proliferative epithelial lesions in over 275 bird species from 70 families. Although generally benign, this emerging disease can sometimes provoke significant outbreaks of mortality. In rallids, there is a single serological record of Avipoxvirus. In this study, we report on field evidence for two avian pox-like outbreaks in Eurasian coots, Fulica atra. In Utterslev Mose, Denmark, 17 birds were found in the winter and early spring of 2006 with putative signs of pox-like lesions on the frontal shield and bill. Similar lesions were detected in a population of c. 30 Eurasian coots from a small wetland in eastern Spain in the winter of 2018. Birds with active lesions were detected up to 73 days after first finding, and percentage of birds with lesions also increased in this period (from 9.1% to 69.6%), then declined. Lesions of individual birds were observed to heal in 2 weeks. Three young coots exhibited severe lesions that hampered breathing. In other 17 wetlands from the same region, pox-like lesions were detected in 8 out of 843 Eurasian coots from three localities (maximum prevalence: 18.8%) and 1 of 8 Crested coots, Fulica cristata, in one locality. Reports from European birdwatchers describing coots with abnormal frontal shields suggest that some of these birds likely suffered also from avian pox. This disease, unnoticed thus far, could be geographically widespread, thus its potential population impact should not be underestimated, especially in Crested coots.

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Mori, Jennifer. "John D. Grainger. The Amiens Truce: Britain and Bonaparte, 1801–1803. Woodbridge and Rochester, NY: Boydell Press, 2004. Pp. x+222. $85.00 (cloth). ISBN 1-843-83041-8." Journal of British Studies 44, no. 2 (April 2005): 385–86. http://dx.doi.org/10.1086/429773.

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Williams, Alison, and Laureate House. "Promoting social interaction for individuals with communicative impairments. Making contact. Edited by M. Suzanne Zeedyk, 1st edition. Jessica Kingsley, 2008. pages: 192, ISBN: 978-1-843-10539-8." International Journal of Geriatric Psychiatry 25, no. 2 (February 2010): 218. http://dx.doi.org/10.1002/gps.2329.

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de Witte, Pieter Bas, Christiaan J. A. van Bergen, Babette L. de Geest, Floor Willeboordse, Joost H. van Linge, Yvon M. den Hartog, Magritha (Margret) M H P Foreman-van Drongel, et al. "Treatment of decentered developmental dysplasia of the hip under the age of 1 year: an evidence-based clinical practice guideline - Part 2." EFORT Open Reviews 7, no. 8 (August 1, 2022): 542–53. http://dx.doi.org/10.1530/eor-21-0126.

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Background and purpose Diagnostics and treatment of developmental dysplasia of the hip (DDH) are highly variable in clinical practice. To obtain more uniform and evidence-based treatment pathways, we developed the ‘Dutch guideline for DDH in children < 1 year’. This study describes recommendations for unstable and decentered hips. Materials and methods The Appraisal of Guidelines for Research and Evaluation criteria (AGREE II) were applied. A systematic literature review was performed for six predefined guideline questions. Recommendations were developed, based on literature findings, as well as harms/benefits, patient/parent preferences, and costs (GRADE). Results The systematic literature search resulted in 843 articles and 11 were included. Final guideline recommendations are (i) Pavlik harness is the preferred first step in the treatment of (sub) luxated hips; (ii) follow-up with ultrasound at 3–4 and 6–8 weeks; (iii) if no centered and stable hip after 6–8 weeks is present, closed reduction is indicated; (iv) if reduction is restricted by limited hip abduction, adductor tenotomy is indicated; (v) in case of open reduction, the anterior, anterolateral, or medial approach is advised, with the choice based on surgical preference and experience; (vi) after reduction (closed/open), a spica cast is advised for 12 weeks, followed by an abduction device in case of residual dysplasia. Interpretation This study presents recommendations on the treatment of decentered DDH, based on the available literature and expert consensus, as Part 2 of the first official and national evidence-based ‘Guideline for DDH in children < 1 year’. Part 1 describes the guideline sections on centered DDH in a separate article.

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Chen, X. B., S. A. Abdulrazak, W. J. Shand, and E. R. Ørskov. "The effect of supplementing straw with barley or unmolassed sugar-beet pulp on microbial protein supply in sheep estimated from urinary purine derivative excretion." Animal Science 55, no. 3 (December 1992): 413–17. http://dx.doi.org/10.1017/s0003356100021103.

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AbstractFour sheep (live weight 39 to 42 kg) fitted with rumen cannulas were offered ammonia-treated barley straw alone (control) or supplemented with unmolassed sugar-beet pulp or rolled barley at 0·20 or 0·40 of the total diet on a fresh weight basis (SBP20, SBP40, B20 and B40, respectively) using a 4 × 5 randomized block design. Total diet intakes were 710, 873, 1054, 843 and 1021 g dry matter per day for control, SBP20, SBP40, B20 and B40 respectively. The intake of straw was depressed significantly with SBP40 and B40 (P < 0·05). Rumen pH and ammonia concentration decreased, and total volatile fatty acid concentrations increased (P < 0·05) with increasing level of supplementation for both supplements. Rumen liquid outflow rate was affected little by the supplementation although this measurement for B40 was significantly higher than that for the other treatments. Microbial protein supply, estimated from urinary excretion of purine derivatives, increased significantly with the increasing amounts of supplements (4·5, 6·7, 8·5, 7·1 and 9·0 (s.e.d. 0·73) g N per day for control, SBP20, SBP40, B20 and B40 respectively) (P < 0·05). The calculated efficiency of microbial protein production was 12·8, 14·2, 14·3, 15·7 and 14·5 (s.e.d. 1·45) g N per kg digestible organic matter intake (DOMI) for the five treatments. Although this value was lowest with the control, differences between treatments were not significant (P > 0·05). It seems that microbial protein yield per unit DOMI for a diet based on ammonia-treated straw could not be improved substantially by supplementation with sugar-beet pulp or barley.

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Hasni, Issam, Julien Andréani, Philippe Colson, and Bernard La Scola. "Description of Virulent Factors and Horizontal Gene Transfers of Keratitis-Associated Amoeba Acanthamoeba Triangularis by Genome Analysis." Pathogens 9, no. 3 (March 16, 2020): 217. http://dx.doi.org/10.3390/pathogens9030217.

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Acanthamoeba triangularis strain SH 621 is a free-living amoeba belonging to Acanthamoeba ribo-genotype T4. This ubiquitous protist is among the free-living amoebas responsible for Acanthamoeba keratitis, a severe infection of human cornea. Genome sequencing and genomic comparison were carried out to explore the biological functions and to better understand the virulence mechanism related to the pathogenicity of Acanthamoeba keratitis. The genome assembly harbored a length of 66.43 Mb encompassing 13,849 scaffolds. The analysis of predicted proteins reported the presence of 37,062 ORFs. A complete annotation revealed 33,168 and 16,605 genes that matched with NCBI non-redundant protein sequence (nr) and Cluster of Orthologous Group of proteins (COG) databases, respectively. The Kyoto Encyclopedia of Genes and Genomes Pathway (KEGG) annotation reported a great number of genes related to carbohydrate, amino acid and lipid metabolic pathways. The pangenome performed with 8 available amoeba genomes belonging to genus Acanthamoeba revealed a core genome containing 843 clusters of orthologous genes with a ratio core genome/pangenome of less than 0.02. We detected 48 genes related to virulent factors of Acanthamoeba keratitis. Best hit analyses in nr database identified 99 homologous genes shared with amoeba-resisting microorganisms. This study allows the deciphering the genome of a free-living amoeba with medical interest and provides genomic data to better understand virulence-related Acanthamoeba keratitis.

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Farah, W., C. Flynn, M. Bailes, A. Jameson, T. Bateman, D. Campbell-Wilson, C. K. Day, et al. "Five new real-time detections of fast radio bursts with UTMOST." Monthly Notices of the Royal Astronomical Society 488, no. 3 (July 4, 2019): 2989–3002. http://dx.doi.org/10.1093/mnras/stz1748.

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Abstract We detail a new fast radio burst (FRB) survey with the Molonglo Radio Telescope, in which six FRBs were detected between 2017 June and 2018 December. By using a real-time FRB detection system, we captured raw voltages for five of the six events, which allowed for coherent dedispersion and very high time resolution (10.24 $\mu$s) studies of the bursts. Five of the FRBs show temporal broadening consistent with interstellar and/or intergalactic scattering, with scattering time-scales ranging from 0.16 to 29.1 ms. One burst, FRB181017, shows remarkable temporal structure, with three peaks each separated by 1 ms. We searched for phase-coherence between the leading and trailing peaks and found none, ruling out lensing scenarios. Based on this survey, we calculate an all-sky rate at 843 MHz of $98^{+59}_{-39}$ events sky−1 d−1 to a fluence limit of 8 Jy ms: a factor of 7 below the rates estimated from the Parkes and ASKAP telescopes at 1.4 GHz assuming the ASKAP-derived spectral index α = −1.6 (Fν ∝ να). Our results suggest that FRB spectra may turn over below 1 GHz. Optical, radio, and X-ray follow-up has been made for most of the reported bursts, with no associated transients found. No repeat bursts were found in the survey.

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Rocha, G. A., D. F. Lima, E. R. Rodrigues, R. S. Leão, T. W. Folescu, M. C. Firmida, R. W. F. Cohen, R. M. Albano, and E. A. Marques. "Species distribution, sequence types and antimicrobial resistance of Acinetobacter spp. from cystic fibrosis patients." Epidemiology and Infection 146, no. 4 (December 28, 2017): 524–30. http://dx.doi.org/10.1017/s0950268817002849.

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AbstractAcinetobacter spp. are important healthcare pathogens, being closely linked to antibiotic resistance and outbreaks worldwide. Although such species are rarely observed in patients with cystic fibrosis (CF), we describe the characteristics of 53 strains of Acinetobacter spp. isolated from the sputum of 39 Brazilian patients with CF. The species distribution was A. baumannii (n = 29), A. pittii (n = 13), A. nosocomialis (n = 8), A. seifertii (n = 1), A. soli (n = 1) and A. variabilis (n = 1) determined by partial rpoB gene sequencing. Sixteen strains (10 A. baumannii, 3 A. pittii and 3 A. nosocomialis) were multidrug-resistant (MDR) by disk diffusion test (30%) and eight MDR carbapenem-resistant A. baumannii strains harboured the blaOXA-23-like oxacillinase gene. Thirty-three sequence types (STs) were identified by multilocus sequence typing of which eight were novel (A. baumannii: 843, 844, 845, 847, 848; A. pitti: 643; A. nosocomialis: 862 and A. seifertii: 846); six STs (2 A. baumannii, 3 A. pittii and 1 A. nosocomialis) were found in more than one patient. Four strains of A. baumannii were assigned to two common clonal complexes (CCs), namely, CC1 (ST1, ST20 and ST160), and CC79 (ST79). This study underlines the extensive species diversity of Acinetobacter spp. strains in CF lung infections which may present difficulties for therapy due to significant antimicrobial resistance.

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45

Smietanska, Joanna, Joanna Sliwiak, Miroslaw Gilski, Zbigniew Dauter, Radoslaw Strzalka, Janusz Wolny, and Mariusz Jaskolski. "A new modulated crystal structure of the ANS complex of the St John's wort Hyp-1 protein with 36 protein molecules in the asymmetric unit of the supercell." Acta Crystallographica Section D Structural Biology 76, no. 7 (June 17, 2020): 653–67. http://dx.doi.org/10.1107/s2059798320006841.

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Superstructure modulation, with violation of the strict short-range periodic order of consecutive crystal unit cells, is well known in small-molecule crystallography but is rarely reported for macromolecular crystals. To date, one modulated macromolecular crystal structure has been successfully determined and refined for a pathogenesis-related class 10 protein from Hypericum perforatum (Hyp-1) crystallized as a complex with 8-anilinonaphthalene-1-sulfonate (ANS) [Sliwiak et al. (2015), Acta Cryst. D71, 829–843]. The commensurate modulation in that case was interpreted in a supercell with sevenfold expansion along c. When crystallized in the additional presence of melatonin, the Hyp-1–ANS complex formed crystals with a different pattern of structure modulation, in which the supercell shows a ninefold expansion of c, manifested in the diffraction pattern by a wave of reflection-intensity modulation with crests at l = 9n and l = 9n ± 4. Despite complicated tetartohedral twinning, the structure has been successfully determined and refined to 2.3 Å resolution using a description in a ninefold-expanded supercell, with 36 independent Hyp-1 chains and 156 ANS ligands populating the three internal (95 ligands) and five interstitial (61 ligands) binding sites. The commensurate superstructures and ligand-binding sites of the two crystal structures are compared, with a discussion of the effect of melatonin on the co-crystallization process.

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46

Merkus, PJ, S. Verver, EE van Essen-Zandvliet, EJ Duiverman, KF Kerrebijn, and PH Quanjer. "Lung volumes measured by the forced rebreathing technique in children with airways obstruction." European Respiratory Journal 5, no. 7 (July 1, 1992): 879–86. http://dx.doi.org/10.1183/09031936.93.05070879.

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Forced rebreathings may recruit trapped gas into the mixing process. Therefore, we assessed the validity and reproducibility of measurements of residual volume (RVN2) by forced rebreathing in a closed circuit using N2 as indicator gas (N2FR) in children with airways obstruction. Validity was studied from measurements of RV obtained by N2FR, by helium dilution during resting ventilation, and by body plethysmograph at low panting frequency in young patients (8-18 yrs, 13 with asthma, forced expiratory volume in one second (FEV1) 93.0 +/- 22.8% pred; 12 with cystic fibrosis (CF), FEV1 80.4 +/- 16.4% pred). Reproducibility of RVN2 was assessed from duplicate measurements in 73 patients with asthma before and after bronchodilation (FEV1 81.4 +/- 13.7 and 99.6 +/- 11.5% pred, respectively), and in nine patients with CF; the total lung capacity (TLC) was unaffected by bronchodilation; 3,797 +/- 830 ml and 3,807 +/- 843 ml, respectively. Gas dilution methods gave comparable results in all subjects but gave lower values than plethysmography in patients with cystic fibrosis. Reproducibility was satisfactory, median differences between duplicate measurements of RVN2 and TLCN2 varying between 13 and 46 ml, respectively. We conclude that N2FR is quickly performed and well-tolerated. Lung volumes are highly reproducible and agree well with those obtained with the helium dilution method. Deep inspirations do not seem to overcome gas trapping in patients with CF.

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47

Vera-San, Martín T., M. Palacios, G. Ormazabal, E. Gonzalez, and L. Gutierrez. "Population and infrastructure vulnerability study under a tsunami scenario in the city of Manta-Ecuador." Disaster Advances 16, no. 3 (February 15, 2023): 1–12. http://dx.doi.org/10.25303/1603da01012.

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Ecuador is a country with frequent seismic and tsunamigenic events due to its close location to a subduction zone between the plates of Nazca and South America. The main objective of this study was to assess the vulnerability of the population and infrastructure of the city of Manta-Ecuador towards a tsunami event. To evaluate the infrastructures, fragility and vulnerability index functions were used, while only fragility functions were considered for the population. Manta has a population of 249,868 permanent inhabitants. The most severe tsunami scenario impacting inhabitants and buildings was selected considering historical data, mathematical modeling, characteristics of infrastructure and population. To perform the simulation, a hypocenter was proposed: 40 km northwest of Manta, 3 km oceanic depth and magnitude moment 8. The simulation results showed floods in 6% of the total area of the city. The analysis conducted by fragility functions indicated that from 2,040 exposed people, 468 would be affected, in particular minors, elderly and disabled groups, not accounting tourists. Also, 221 structures would be affected from 843 exposed in the flooded zones with a maximum flood depth higher than 5 m representing 26% and 0.2 % of the exposed and total buildings in the city respectively. The results of this study would assist in identifying risky and safe areas, shelter buildings, routes and evacuation times during a tsunamigenic event.

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48

Kim, Sang-A., Ji-Won Kim, Koung Jin Suh, Jin Won Kim, Heung-Kwon Oh, Jai Young Cho, Duck-Woo Kim, et al. "Liver and/or lung metastasectomy after cetuximab or bevacizumab+FOLFIRI chemotherapy in patients (pts) with metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 843. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.843.

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843 Background: Some mCRC pts who have liver and/or lung metastases (LLMs) could achieve cure after palliative chemotherapy and conversion surgery (CS) including metastasectomy. Though targeted agents including bevacizumab and cetuximab significantly improved outcomes in mCRC pts, the effect of targeted agents on cure rate after CS has not yet been thoroughly investigated. Methods: We analyzed clinical data of mCRC pts who initially had unresectable LLMs regardless of their size and number and underwent first-line cetuximab or bevacizumab+FOLFIRI. Pts who had metastasis other than liver and lung were excluded. Results: From January 2013 to May 2016, 87 pts (male, 56) were consecutively enrolled: liver-limited metastasis in 42 pts (48.3%), lung-limited metastasis in 17 pts (19.5%), and both liver and lung metastases in 28 pts (32.2%). Median age was 62 years (range, 37-85). K-RAS or N-RAS mutation was detected in 39 pts (46.4%) and B-RAF in 2 pts (3.1%) among mutation evaluated pts. Among them, 35 pts (40.2%) received cetuximab+FOLFIRI and the others (N = 52, 59.8%), bevacizumab+FOLFIRI. Median follow-up time was 20.0 months (range, 1.9-49.1). Response rate was 65.7% in the cetuximab group (CET) and 42.3% in the bevacizumab group (BEV) ( p= 0.032). Median progression-free survival was 19.1 months (95% confidence interval [CI], 11.2-27.1) in CET and 14.1 months (95% CI, 11.5-16.8) in BEV ( p= 0.249). CS was performed in 24 pts (27.6%) after median 8.7 months (range, 2.5-27.3) after initiation of chemotherapy. In CET, 11 pts (31.4%) including 8 pts with partial response (PR) and 3 pts with stable disease (SD) underwent CS and all (100%) attained R0. In BEV, 13 pts (25%) including 6 pts with PR and 7 pts with SD received CS and 11 of them (84.6%) achieved R0. Among pts with R0 resection, median disease-free survival (DFS) was 8.8 months (95% CI, 4.9-12.7) in CET and 3.2 months (95% CI, 0.0-7.4) in BEV ( p= 0.326). Conclusions: A substantial proportion of pts could receive CS after cetuximab or bevacizumab+FOLFIRI chemotherapy. CET tended to show higher rate of CS. However, the median DFS after R0 resection was not significantly different between the two groups.

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49

Li, Xiao C., Yuan Shao, and Jia L. Zhuo. "AT1a receptor signaling is required for basal and water deprivation-induced urine concentration in AT1a receptor-deficient mice." American Journal of Physiology-Renal Physiology 303, no. 5 (September 1, 2012): F746—F756. http://dx.doi.org/10.1152/ajprenal.00644.2011.

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It is well recognized that ANG II interacts with arginine vasopressin (AVP) to regulate water reabsorption and urine concentration in the kidney. The present study used ANG II type 1a (AT1a) receptor-deficient (Agtr1a−/−) mice to test the hypothesis that AT1a receptor signaling is required for basal and water deprivation-induced urine concentration in the renal medulla. Eight groups of wild-type (WT) and Agtr1a−/− mice were treated with or without 24-h water deprivation and 1-desamino-8-d-AVP (DDAVP; 100 ng/h ip) for 2 wk or with losartan (10 mg/kg ip) during water deprivation. Under basal conditions, Agtr1a−/− mice had lower systolic blood pressure ( P < 0.01), greater than threefold higher 24-h urine excretion (WT mice: 1.3 ± 0.1 ml vs. Agtr1a−/− mice: 5.9 ± 0.7 ml, P < 0.01), and markedly decreased urine osmolality (WT mice: 1,834 ± 86 mosM/kg vs. Agtr1a−/− mice: 843 ± 170 mosM/kg, P < 0.01), without significant changes in 24-h urinary Na+ excretion. These responses in Agtr1a−/− mice were associated with lower basal plasma AVP (WT mice: 105 ± 8 pg/ml vs. Agtr1a−/− mice: 67 ± 6 pg/ml, P < 0.01) and decreases in total lysate and membrane aquaporin-2 (AQP2; 48.6 ± 7% of WT mice, P < 0.001) and adenylyl cyclase isoform III (55.6 ± 8% of WT mice, P < 0.01) proteins. Although 24-h water deprivation increased plasma AVP to the same levels in both strains, 24-h urine excretion was still higher, whereas urine osmolality remained lower, in Agtr1a−/− mice ( P < 0.01). Water deprivation increased total lysate AQP2 proteins in the inner medulla but had no effect on adenylyl cyclase III, phosphorylated MAPK ERK1/2, and membrane AQP2 proteins in Agtr1a−/− mice. Furthermore, infusion of DDAVP for 2 wk was unable to correct the urine-concentrating defects in Agtr1a−/− mice. These results demonstrate that AT1a receptor-mediated ANG II signaling is required to maintain tonic AVP release and regulate V2 receptor-mediated responses to water deprivation in the inner medulla.

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50

Pigneux, Arnaud P. M., Isabelle L. Ray-Coquard, Philippe J. M. Dalivoust, Gaelle Chenuc Biostat, and Anne M. Bastie. "Darbepoetin Alfa (DA) - Pattern of Use and Outcomes in Adult Patients with Non-Myeloid Malignancies and Chemotherapy-Induced Anemia: A French Observational Study." Blood 108, no. 11 (November 16, 2006): 3347. http://dx.doi.org/10.1182/blood.v108.11.3347.3347.

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Abstract INTRODUCTION: DA is widely used to treat anemia in patients undergoing chemotherapy (CT) for non-myeloid malignancies. Three years after the commercialization of DA in France, a study of the pattern of DA use in daily practice was conducted in this population. METHODS: A nationwide, retrospective observational study of DA use and patient outcomes was conducted in 239 centers between September 2004 and May 2005. Adult patients with non-myeloid malignancies, who had received DA for CT-induced anemia for at least three 3- or 4-weekly or at least five 2-weekly CT cycles (min. 9–12 weeks) were studied. Response was defined as hemoglobin (Hb) ≥ 12g/dL or a Hb increase of at least 2 g/dL from baseline to week 6/8. In addition, the proportion of patients achieving a Hb level of ≥ 11 g/dL as suggested by NCCN guidelines was assessed. Hb levels were evaluated at baseline, week 3 and week 6 (CT cycles of 21 days) or week 4 and week 8 (CT cycles of 15 or 28 days). RESULTS: Of 2017 patients recruited, 1865 (92.5%) were evaluable at week 6 or 8. Analyses were conducted on the evaluable patient population. A total of 51% were female and the mean age was 62.5 years [range: 18–96 years]. The most common tumor types were non-myeloid hematological malignancies (25%), lung cancer (21%), breast cancer (16%) and gastrointestinal tumors (14%). A total of 37% of centers were University hospitals, 30% public hospitals, 21% private hospitals and 11% specialized cancer centers. Baseline mean Hb level was 10g/dL [range 5–16.6 g/dL]. A total of 843 patients at week 0 (45.4%) had a Hb <10g/dL. The first DA dose was administered to 40% of patients at the first CT cycle and to 60% of patients at subsequent cycles. At week 6/8, 707 patients (38%) had a Hb ≥ 12 g/dL and 1096 patients (58.8%) had a Hb ≥ 11 g/dL. During the study period, between week 0 and week 6/8, 272 pts (15.9%) received RBC transfusions. CONCLUSIONS: Despite the very short follow-up of 6/8 weeks, almost 40% of the patients achieved a Hb ≥ 12 g/dL. More importantly, the proportion of patients reaching a Hb level within the range recommended by NCCN guidelines (≥ 11 g/dL) at this short follow-up was around 60%, which is comparable to results published in other trials of DA.

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