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Статті в журналах з теми "808.899 6"

Автор: Grafiati

Опубліковано: 22 жовтня 2022

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1

Yarwood, Mary. "Prisoners’ Rights: Principles and Practice S. Easton. London: Routledge (2011) 304pp. £90.00hb ISBN 978-1-84392-809-6 £24.99pb ISBN 978-1-84392-808-9." Howard Journal of Criminal Justice 51, no. 2 (April 4, 2012): 238–39. http://dx.doi.org/10.1111/j.1468-2311.2012.00714_1.x.

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2

TSUJI, Tadashi, Takaki SAKITSU, Ryutaro FUKUSHIMA, and Tsuyoshi KATO. "809 High Performance Analysis On Gas Engine - Gas Turbine Combined Cycle." Proceedings of Conference of Kansai Branch 2008.83 (2008): _8–9_. http://dx.doi.org/10.1299/jsmekansai.2008.83._8-9_.

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3

Jette, Diane U., Mary Stilphen, Vinoth K. Ranganathan, Sandra Passek, Frederick S. Frost, and Alan M. Jette. "Interrater Reliability of AM-PAC “6-Clicks” Basic Mobility and Daily Activity Short Forms." Physical Therapy 95, no. 5 (May 1, 2015): 758–66. http://dx.doi.org/10.2522/ptj.20140174.

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BackgroundThe interrater reliability of 2 new inpatient functional short-form measures, Activity Measure for Post-Acute Care (AM-PAC) “6-Clicks” basic mobility and daily activity scores, has yet to be established.ObjectiveThe purpose of this study was to examine the interrater reliability of AM-PAC “6-Clicks” measures.DesignA prospective observational study was conducted.MethodsFour pairs of physical therapists rated basic mobility and 4 pairs of occupational therapists rated daily activity of patients in 1 of 4 hospital services. One therapist in a pair was the primary therapist directing the assessment while the other therapist observed. Each therapist was unaware of the other's AM-PAC “6-Clicks” scores. Reliability was assessed with intraclass correlation coefficients (ICCs), Bland-Altman plots, and weighted kappa.ResultsThe ICCs for the overall reliability of basic mobility and daily activity were .849 (95% confidence interval [CI]=.784, .895) and .783 (95% CI=.696, .847), respectively. The ICCs for the reliability of each pair of raters ranged from .581 (95% CI=.260, .789) to .960 (95% CI=.897, .983) for basic mobility and .316 (95% CI=−.061, .611) to .907 (95% CI=.801, .958) for daily activity. The weighted kappa values for item agreement ranged from .492 (95% CI=.382, .601) to .712 (95% CI=.607, .816) for basic mobility and .251 (95% CI=.057, .445) to .751 (95% CI=.653, .848) for daily activity. Mean differences between raters' scores were near zero.LimitationsRaters were from one health system. Each pair of raters assessed different patients in different services.ConclusionsThe ICCs for AM-PAC “6-Clicks” total scores were very high. Levels of agreement varied across pairs of raters, from large to nearly perfect for physical therapists and from moderate to nearly perfect for occupational therapists. Levels of agreement for individual item scores ranged from small to very large.

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4

Wakatsuki, Hidemitsu, Masaharu Kudoh, and Katsuei Shibuki. "809 Layer-specific no release in the rat auditory cortex." Neuroscience Research 28 (January 1997): S102. http://dx.doi.org/10.1016/s0168-0102(97)90271-6.

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5

MITREV, Z., T. ANGUSEVA, V. PETROVSKI, and V. AMPOVA. "809 Surgical approach in patients with end-stage heart failure." European Journal of Heart Failure Supplements 2, no. 1 (June 2003): 177–78. http://dx.doi.org/10.1016/s1567-4215(03)90540-6.

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6

Steinman, E. A., A. N. Tereshchenko, Valeri I. Orlov, and F. G. Kirscht. "Fine Structure of Dislocation Related PL Bands D1 and D2 in Silicon." Solid State Phenomena 108-109 (December 2005): 767–72. http://dx.doi.org/10.4028/www.scientific.net/ssp.108-109.767.

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The samples of p- and n-doped Fz Si were deformed in 3-point bending mode in the temperature range 800-950°C. The fine structure of dislocation related luminescence in the region of D1 and D2 bands was most pronounced at lowest rate of deformation. The temperature variation of intensity of individual lines did not reveal any thermalization effects. It implies that centers responsible for different individual lines are situated in diverse places. The most narrow lines with maximum positions of 802 meV and 807 meV (D1 band) and 869 meV and 873 meV (D2 band) are rapidly quenched with increase in temperature, while the broader background lines survive at higher temperature. The new line with maximum position at about 882 meV appears in the D2 band with enhanced carbon doping. It was found that at higher P-doping the low energy fine structure lines 802 meV and 869 meV are absent. Besides, the Fz samples with different P doping level from 6×1014 cm-3 to 1.2×1016 cm-3 demonstrate quite a different temperature variation of broad background lines. At lowest level of P-doping they move to low energy side at temperature above 30K, while at P-doping above 1015 cm-3 these lines move to higher energy in the same temperature range. A possible explanation of this observation can be related to distribution of electrons in the cband. It implies that the corresponding electronic transitions occur between the edge of conduction band and deep states.

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7

Bilecen, Tuncay. "Kemal Siyahhan (2016). Mülteci, İstanbul: Sel Yayıncılık, (ISBN: 978-975-570-809-6), 191 Sayfa." Göç Dergisi 4, no. 1 (May 1, 2017): 110–14. http://dx.doi.org/10.33182/gd.v4i1.574.

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8

Srinivasan, Thothadri, Panneerselvam Yuvaraj, Boreddy S. R. Reddy, and Devadasan Velmurugan. "8,8-Dimethyl-8,9-dihydro-7H-chromeno[2,3-b]quinoline-10,12-dione." Acta Crystallographica Section E Structure Reports Online 69, no. 2 (January 19, 2013): o254. http://dx.doi.org/10.1107/s1600536813001050.

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In the title compound, C18H15NO3, the fused benzopyran and pyridine rings are essentially coplanar [r.m.s. deviation = 0.0533 Å with a maximum deviation of 0.080 (1) Å for a benzene C atom]. The cyclohexanone ring adopts an envelope conformation with the dimethyl-substituted C atom 0.660 (2) Å out of the plane formed by the remaining ring atoms (r.m.s. deviation = 0.0305 Å). The dihedral angle between the mean planes of the pyran and cyclohexanone rings is 12.95 (6)°. In the crystal, molecules are linkedviaC—H...O hydrogen bonds, leading to chains running along [011].

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9

Shikhaliev, Kh S., D. V. Kryl’skii, A. Yu Potapov, and M. Yu Krysin. "Synthesis of 8,8-R,R-8,9-dihydro[1,2,4]triazolo[1,5-a]quinazolin-6(7H)-ones." Russian Chemical Bulletin 54, no. 12 (December 2005): 2903–4. http://dx.doi.org/10.1007/s11172-006-0207-1.

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10

Bölükbaşı Ateş, Gamze, Ayşe Ak Can, and Murat Gülsoy. "Investigation of photobiomodulation potentiality by 635 and 809 nm lasers on human osteoblasts." Lasers in Medical Science 32, no. 3 (January 23, 2017): 591–99. http://dx.doi.org/10.1007/s10103-017-2153-6.

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11

MORITA, Shinji, and Hiromitsu KAWAZOE. "809 Video Image Analysis for Free Flight Vehicle with The Body Fit gauge." Proceedings of Conference of Kansai Branch 2004.79 (2004): _8–15_—_8–16_. http://dx.doi.org/10.1299/jsmekansai.2004.79._8-15_.

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12

Monsalud, Cherie Faith, Kamaljit Singh, Erin McElvania, Donna Schora, Jennifer Grant, Mary Alice Lavin, Rachel Lim, and Shane Zelencik. "809. Modified Laboratory Reporting to Prevent Catheter-Associated Urinary Tract Infections (CAUTIs)." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S447—S448. http://dx.doi.org/10.1093/ofid/ofaa439.999.

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Abstract Background Catheter-associated urinary tract infections (CAUTIs) are among the most common healthcare-associated infections. Many patients at our institution with a CAUTI do not have signs or symptoms of infection and bacterial growth likely represents asymptomatic bacteriuria (ASB). As a result, we implemented a Modified Lab Workflow (MLW) focused on diagnostic stewardship to improve urine culture (UCx) reporting and prevent misclassification and unnecessary treatment of CAUTIs. Methods On Sep. 1, 2019, laboratory reporting of Foley UCx was modified according to the protocol in Figure 1. UCx results were divided into 3 groups: (1) no growth, (2) mixed bacterial flora (≥3 organisms) not consistent with infection or (3) growth of ≤2 organisms with at least 1 organism ≥105 cfu/ml per National Healthcare Safety Network (NSHN) CAUTI definition. Group 3 UCx were resulted with instructions to the clinician (see Figure 1.). When requested, group 3 results were reviewed by Infection Prevention and released with organism identification and antibiotic susceptibility if it met Infectious Diseases Society of America (IDSA) CAUTI criteria. Otherwise they were resulted as: “Bacterial growth indicative of contamination or colonization.” Figure 1. Modified Laboratory Workflow for Reporting Urine Cultures from Foley Catheters Results Between Sep. 1, 2019 to Mar. 1, 2020, a total of 134 UCx from catheterized patients were reviewed. Forty-two (31%) of UCx were from patients with a Foley in-situ ≥48 hours and processed through MLW; 92 UCx were from a Foley in place < 48 hours and excluded from the study. Of the 42 UCx processed via MLW, 16 (38%) were no growth and 7 (17%) had bacterial growth suggestive of contamination. For group 3, 19/42 (45%) had growth of significant bacteria but only 1(5%) met IDSA criteria for reporting. During the study, 6 additional CAUTIs were reported due to incorrect specimen labeling causing Foley urine specimens to subvert MLW. Conclusion During our study, we identified 1 CAUTI through apt MLW use. Seven total CAUTIs occurred (SIR=0.66); a majority due to incorrect UCx source labeling, resulting in missed MLW screening. Ten CAUTIs (SIR=0.97) were reported in the preceding 6 months. As part of a comprehensive CAUTI prevention program, a MLW can help reduce classification of ASB as a CAUTI. Education to providers on precise labeling of UCx source is a key component of a successful MLW. Disclosures All Authors: No reported disclosures

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13

Gangar, Vidhya, Michael S. Curiale, Armando D’Onorio, Ann Schultz, Ronald L. Johnson, Vincent Atrache, J. Agin, et al. "VIDAS® Enzyme-Linked Immunofluorescent Assay for Detection of Listeria in Foods: Collaborative Study." Journal of AOAC INTERNATIONAL 83, no. 4 (July 1, 2000): 903–18. http://dx.doi.org/10.1093/jaoac/83.4.903.

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Abstract The VIDAS LIS method and the traditional culture methods for detection of Listeria species in food were evaluated in a multilaboratory comparative study. The 6 foods tested were either naturally contaminated or inoculated with 3 different concentrations of Listeria. Results for each food and each contamination level with the VIDAS LIS method were as good as or better than those obtained with the traditional culture method. Of 1558 samples tested, 935 were positive: 839 by the VIDAS method and 809 by standard culture methods. Overall false negative rates were 10.3 and 13.5% for the VIDAS LIS and culture methods, respectively. The false positive rate for the VIDAS LIS assay was 1.4% based on 9 VIDAS LIS positive assays that did not confirm positive by isolation of Listeria. The agreement between the VIDAS LIS and culture methods for all samples tested was 86%.

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14

Drake, Charles G., Russell Kent Pachynski, Sumit Kumar Subudhi, Douglas G. McNeel, Emmanuel S. Antonarakis, Todd Michael Bauer, Daniel Patricia, et al. "Safety and preliminary immunogenicity of JNJ-64041809, a live attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e16509-e16509. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e16509.

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e16509 Background: The safety and immunogenicity of JNJ-64041809 (JNJ-809), a live attenuated, double-deleted Listeria monocytogenes (LADD- Lm)-based immunotherapy targeting relevant prostate cancer antigens, was evaluated in a phase 1, multicenter, open-label study in patients (pts) with mCRPC. Methods: Men aged ≥18 years with progressive mCRPC who had received ≥2 prior approved therapies were included. The recommended phase 2 dose (RP2D) and the safety and immunogenicity of JNJ-809 were evaluated. Dose-limiting toxicities (DLTs), adverse events (AEs), T cell response, tumor response, and JNJ-809 bacterial shedding profile were assessed at 2 dose levels, 1 x 108 and 1 x 109 colony forming units (CFU). Results: 26 pts (median age 66.5 years, White 96%) were enrolled (1 x 108 CFU, n = 6; 1 x 109 CFU, n = 20). Median duration of treatment was 2.5 months (range 0-9.7). No DLTs occurred and 1 x 109 CFU was selected as the RP2D. Most common AEs were chills (n = 24, 92%), pyrexia (n = 21, 81%), and fatigue (n = 16, 62%). Grade ≥3 AEs were reported in 18 (69%) pts and serious AEs in 7 (27%) pts including 1 pt with investigator-assessed treatment-related grade 3 intestinal obstruction. At 1 x 108 CFU, all pts had negative blood cultures. At 1 x 109 CFU, 6 pts had LADD- Lm-positive blood cultures on day 1; blood cultures on all subsequent days were negative. JNJ-809 transiently induced peripheral cytokines including interferon-γ, interleukin-10, and tumor necrosis factor-α. Of 7 evaluable pts (1 x 109 CFU), post-treatment T cell responses were demonstrated in 6 pts to the Listeria antigen LLO and in 5 pts to ≥1 of the 4 encoded tumor antigens. Best overall response was stable disease (SD) in 13/25 evaluable pts with SD ≥16 weeks in 4 pts. The study was terminated early as the data collected from 26 pts were considered sufficient to evaluate safety and immune responses. Conclusions: JNJ-809 has a manageable safety profile consistent with that of other LADD- Lm-based therapies. Observed activation of immune responses with monotherapy did not translate into clinical activity, and further development of JNJ-809 will likely require a combination approach. Clinical trial information: NCT02625857.

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15

Cruz, Silvia, Justo Cobo, John N. Low, and Christopher Glidewell. "Hydrogen-bonded sheets in 4-amino-8,8-dimethyl-2-(methylsulfanyl)-8,9-dihydropyrimidino[4,5-b]quinolin-6(7H)-one." Acta Crystallographica Section E Structure Reports Online 62, no. 11 (October 13, 2006): o4933—o4935. http://dx.doi.org/10.1107/s1600536806040633.

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16

&NA;. "Dis Colon Rectum, Vol. 49, No. 6, June 2006, pp. 792-809 (DOI: 10.1007/s10350-006-0536-z)." Diseases of the Colon & Rectum 49, no. 7 (July 2006): 1084. http://dx.doi.org/10.1007/s10350-006-0649-4.

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17

Fassuliotis, Thomas M. "Re: Decreasing the Risk of Human Immunodeficiency Virus or Hepatitis B Virus Infection During Endoscopic Surgery, by J. P. Whelan and B. Finlayson, J. Urol., 145: 807–809, 1991." Journal of Urology 147, no. 1 (January 1992): 174. http://dx.doi.org/10.1016/s0022-5347(17)37189-6.

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18

Walo-Martín, Daniel, Franzette Paz-Buclatin, Susana Ríos, Inocencio R. Martín, Leopoldo L. Martin, Airán Ródenas, Vladimir N. Sigaev, Vitaliy I. Savinkov, and Georgiy Y. Shakhgildyan. "Temperature Sensing with Nd3+ Doped YAS Laser Microresonators." Applied Sciences 11, no. 3 (January 26, 2021): 1117. http://dx.doi.org/10.3390/app11031117.

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Yttria–alumina–silica (YAS) glass microspheres doped with Nd3+ ions were excited with a 532 nm continuous laser in order to study the dependency of the wavelength of the whispering gallery mode (WGM) peaks on the temperature of the sample. This was possible due to a previous calibration of the 808 nm and 890 nm emission bands of the Nd:YAS glass sample for different temperatures using the fluorescence intensity ratio (FIR) technique. A maximum sensitivity of 15 × 10−6 K−1 and a temperature resolution limit of 0.2 K were obtained for the microsphere sensor. Moreover, laser emission at 1064 nm was observed by continuous pumping at 532 nm, and a power threshold of 100 mW was determined. Upconversion emissions of Nd3+ were also studied by exciting the sample at 808 nm.

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19

Netter, Karl J., and P. Netter. "The chemical languages of the nervous system: History of scientists and substances. Edited by Josef Donnerer and Fred Lembeck, S. Karger AG, Publishers, Basel, Switzerland, Karger 2006. ISBN 3-8055-8004-5. Pages: 237, Figures: 6." Human Psychopharmacology: Clinical and Experimental 21, no. 8 (2006): 560–61. http://dx.doi.org/10.1002/hup.809.

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20

Ma, Jiajia, Zi Liu, Jitao Wu, Zhongbao Zhou, Xuebao Zhang, Yuanshan Cui, and Chunhua Lin. "Role of application of tadalafil 5 mg once-daily (≥6 months) in men with erectile dysfunction from six randomized controlled trials." Translational Andrology and Urology 9, no. 3 (June 2020): 1405–14. http://dx.doi.org/10.21037/tau-19-809.

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21

Suzuki, Ryo, Kazunari Tanaka, Shinji Kurimoto, and Norio Fujiwara. "Sudden Against-the-Rule Astigmatism 6 Months after Intraocular Lens Implantation with the Kelman Phacoemulsification Procedure: 4 of 809 Cases." Ophthalmologica 204, no. 2 (1992): 71–76. http://dx.doi.org/10.1159/000310272.

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22

Hwang, Chang Heon, and Myung Chul Lee. "Corrigendum to “Reduction malarplasty using a zygomatic arch-lifting technique” [J Plastic Reconstr Aesthet Surg 69 (6) (2016), 809–818]." Journal of Plastic, Reconstructive & Aesthetic Surgery 69, no. 8 (August 2016): 1163. http://dx.doi.org/10.1016/j.bjps.2016.06.012.

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23

Han, Xiu Ping, Bing Hua Yao, Qin Ku Zhang, and Cai Ling Zhang. "Preparation and Catalytic Properties of BaSb₂O₆ Photocatalyst." Materials Science Forum 809-810 (December 2014): 867–71. http://dx.doi.org/10.4028/www.scientific.net/msf.809-810.867.

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The small-stones-like BaSb2O6 had been successfully prepared through two-step reaction by using inexpensive Sb2O3 reactant. The effects of reaction conditions (temperature, time) on photocatalytic efficiency were researched. The photocatalytic activity of BaSb2O6 was evaluated by photodegradation of methylene blue (MB). The results showed that the decolorization rate of methylene blue was over 90% under ultraviolet lamp (500 W) beam for 40min. Its structures and morphologies had been investigated by X-ray powder diffraction (XRD), scanning electron microscopy (SEM). The results showed that XRD pattern of BaSb2O6 was consistent with standard card and morphology of BaSb2O6 was smooth close-packed state "small stones", fine particles & no agglomeration.

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24

Kostrzewa-Susłow, Edyta, Jadwiga Dmochowska-Gładysz, Tomasz Janeczko, Kamila Środa, Krystyna Michalak, and Anna Palko. "Microbial Transformations of 6- and 7-Methoxyflavones in Aspergillus niger and Penicillium chermesinum Cultures." Zeitschrift für Naturforschung C 67, no. 7-8 (August 1, 2012): 411–17. http://dx.doi.org/10.1515/znc-2012-7-809.

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A detailed study of the biotransformation of 6- and 7-methoxyfl avones by four fungal strains (Aspergillus niger strains MB, KB, and SBP; Penicillium chermesinum 113) was carried out. Products of demethylation and also demethylation combined with hydroxylation at C-4’ were identifi ed. The biotransformation products were stronger antioxidants than the substrates.

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25

Schmid, B., O. Bauhofer, A. Ruggieri, and R. Bartenschlager. "809 HEPATITIS C VIRUS PERSISTENCE IN QUIESCENT HEPATIC CELLS UNDER CONDITIONS OF AN INTERFERON-INDUCED ANTIVIRAL RESPONSE." Journal of Hepatology 56 (April 2012): S316. http://dx.doi.org/10.1016/s0168-8278(12)60821-6.

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26

Smith, M. A., L. M. Sayre, V. Anderson, P. L. Richey, S. L. Siedlak, M. F. Beal, N. Kowall, and G. Perry. "809 A specific marker of oxidative protein modifications, 2,4-dinitrophenylhydrazine, labels the neurofibrillary pathology of Alzheimer disease." Neurobiology of Aging 17, no. 4 (January 1996): S201. http://dx.doi.org/10.1016/s0197-4580(96)80811-6.

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27

Yegin, Sirma, and Marcelo Fernandez-Lahore. "A Thermolabile Aspartic Proteinase from Mucor mucedo DSM 809: Gene Identification, Cloning, and Functional Expression in Pichia pastoris." Molecular Biotechnology 54, no. 2 (October 12, 2012): 661–72. http://dx.doi.org/10.1007/s12033-012-9608-6.

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28

Nikolaeva, Anna, Yelena Vaknin, and Gennadiy Zharinov. "PERSONALITY AND CANCER: DIFFERENCES IN THE CLINICAL AND PSYCHOLOGICAL CHARACTERISTICS OF THE PATIENT'S PERSONALITY AT HIGH AND LOW RATES OF TUMOR GROWTH." Problems in oncology 64, no. 6 (June 1, 2018): 805–9. http://dx.doi.org/10.37469/0507-3758-2018-64-6-805-809.

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In this paper are presented the results and comparative analysis of the clinical and psychological research for the patient's personality with prostate cancer with high and low growth rate of the tumor. It was revealed that the nature of the oncological process does not depend on the perception by the patients of the impact of a traumatic event, in which the disease acts. For patients with a high tumor growth rate, the most characteristic are pliability, credulity, subordination (r = 0,887, p

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29

Chernova, A. A., S. Yu Nikulina, and S. S. Tret'yakova. "GENETIC PREDICTORS OF IDIOPATHIC SICK SINUS SYNDROME." Rational Pharmacotherapy in Cardiology 8, no. 6 (January 1, 2012): 804–9. http://dx.doi.org/10.20996/1819-6446-2012-8-6-804-809.

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30

Lushnikov, D. S., A. Y. Zherdev, V. V. Markin, S. B. Odinokov, and A. V. Smirnov. "CALCULATION OF ANGULAR AND SPECTRAL SELECTIVITY FOR FULL-PARALLAX HOLOGRAPHIC STEREOGRAMS." Computer Optics 40, no. 6 (January 1, 2016): 802–9. http://dx.doi.org/10.18287/2412-6179-2016-40-6-802-809.

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31

Tannir, Nizar M., Alice C. Fan, Richard J. Lee, Bradley Curtis Carthon, Othon Iliopoulos, James Walter Mier, Manish R. Patel, et al. "Phase 1 study of glutaminase (GLS) inhibitor CB-839 combined with either everolimus (E) or cabozantinib (Cabo) in patients (pts) with clear cell (cc) and papillary (pap) metastatic renal cell cancer (mRCC)." Journal of Clinical Oncology 36, no. 6_suppl (February 20, 2018): 603. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.603.

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603 Background: CB-839 is a first-in-class inhibitor of GLS that targets tumor glutamine utilization, a pathway upregulated in kidney cancer. CB-839 combines with E or Cabo in pre-clinical RCC models to inhibit metabolic pathways resulting in enhanced anti-tumor activity. The CX-839-001 study includes cohorts evaluating the safety, efficacy and recommended Phase 2 dose (RP2D) of CB-839 in combination with E (CBE) or Cabo (CB-Cabo) in pts with mRCC. Here we report results from the CBE and CB-Cabo cohorts. Methods: Eligibility criteria included mRCC with cc or pap histology, ECOG 0-1, RECIST measurable disease and, for cc pts, treatment with at least 1 prior anti-VEGF therapy. Pts received escalating doses of CB-839 (PO BID) in a 3+3 design, either 400-800 mg with E (10 mg PO QD) or 600-800 mg with Cabo (60 mg PO QD). Tumor response (RECIST 1.1) was assessed every 8 wks. Results: 27 pts (22 cc, 3 pap, 2 other) were enrolled in CB-E escalation (n = 17) and expansion (n = 10) cohorts (7 at 400 mg, 13 at 600 mg, 7 at 800 mg) and 11 pts (9 cc, 2 pap) in CB-Cabo escalation cohorts (6 at 600 mg, 5 at 800 mg). Median prior lines of therapy was 2 for CBE (including 64% of cc pts with ≥2 prior anti-VEGF therapies) and 3 for CB-Cabo (range 0-6). A maximum tolerated dose was not reached; 800 mg was selected as the RP2D for CB-839. The most common treatment-related Gr≥3 AEs were fatigue (11%), anemia, hyperglycemia, and neutropenia (7% each) for CBE (N = 27) and diarrhea (14%) and platelet count decreased (14% including 1 DLT at 600 mg) for CB-Cabo (N = 7). Of 24 evaluable CBE pts there was 1 PR and 21 SD for a disease control rate (DCR = CR + PR + SD) of 92% with a median PFS of 7.1 mo (95% CI 4 - 11). For 9 evaluable CB-Cabo pts the ORR and DCR were 44% (4 PR) and 100%, respectively. Conclusions: The tumor metabolism inhibitor CB-839 combines with full dose of RCC targeted therapies, E and Cabo, with good tolerability and encouraging clinical activity in heavily-pretreated mRCC pts. CB-Cabo ORR and DCR of 44% and 100% are promising, and CBE DCR of 92% and PFS of 7.1 mo compare favorably to historical E monotherapy. Randomized Phase 2 studies have been initiated (CBE) or are planned (CB-Cabo). Clinical trial information: NCT02071862.

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Bartolome, N., P. Aspichueta, M. J. Martinez, B. Ochoa, and Y. Chico. "YI-809 NUCLEAR RUN-ON ASSAYS DEMONSTRATE THAT APOB IS NOT AN ACUTE PHASE PROTEIN IN THE RAT." Atherosclerosis Supplements 8, no. 1 (June 2007): 215. http://dx.doi.org/10.1016/s1567-5688(07)71819-6.

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Fang, D. Q., C. T. Federici, and M. L. Roose. "Development of molecular markers linked to a gene controlling fruit acidity in citrus." Genome 40, no. 6 (December 1, 1997): 841–49. http://dx.doi.org/10.1139/g97-809.

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Fruit juice pH, titratable acidity, or citric acid content was measured in 6 populations derived from an acidless pummelo (pummelo 2240) (Citrus maxima (Burm.) Merrill). The acidless trait in pummelo 2240 is controlled by a single recessive gene called acitric. Using bulked segregant analysis, three RAPD markers were identified as linked to acitric. RAPD marker OpZ20410, which mapped 1.2 cM from acitric, was cloned and sequenced, and a sequence characterized amplified region (SCAR) marker (SCZ20) was developed. The SCZ20-410 marker allele that is linked to the acitric allele occurs only in pummelo 2240 and other pummelos, and therefore, this SCAR marker should be useful as a dominant or codominant marker for introgressing acitric into mandarins and other citrus species. Using the cloned OpZ20410 band as a hybridization probe revealed a codominant RFLP marker called RFZ20 that mapped 1.2 cM from acitric. Progeny homozygous (acac) for the acitric allele had citric acid content below 10 μM, the minimum level detectable by high pressure liquid chromatography. The citric acid content of fruit juice from progeny predicted to be heterozygous (Acac) for acitric by the above markers was about 30% lower than that of juice from individuals predicted to be homozygous (AcAc) for the normal acid allele. Markers OpZ20410, SCZ20, and RFZ20 were highly polymorphic among 59 citrus accessions, and using one or more of these markers would allow citrus breeders to select seedling progeny heterozygous for acitric in nearly all crosses between pummelo 2240 or its offspring and other citrus genotypes.Key words: Citrus, fruit acidity, citric acid, RAPD, SCAR, RFLP.

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Shanahan, Thomas, Liam Barrett, Richard Body, Virginia Newcombe, Rebecca Fish, and Anisa Jafar. "809 Survey of current and former academic clinical fellows in emergency medicine in the UK." Emergency Medicine Journal 39, no. 3 (February 21, 2022): 257.3–258. http://dx.doi.org/10.1136/emermed-2022-rcem.30.

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Aims/Objectives/BackgroundAcademic emergency medicine (EM) is a young field in the United Kingdom (UK) with a small critical mass of clinical academics, who have protected time to conduct research alongside clinical duties. There is a little published information on the academic training available to emergency physicians.In the UK, academic clinical fellowships (ACFs) offer a structured opportunity for trainees to develop skills and experience in research alongside clinical training. We aimed to capture information on the prior experience of emergency medicine (EM) fellows, as well as how the ACFs were structured and the next career steps for fellows upon completion.Methods/DesignA ten-question survey was designed by the project steering committee and circulated UK wide to all current fellows in EM and those that completed the programme in the last five years. Fellows were identified by contacting programme leads in every region. Data was collected via SurveyMonkey® between 18thFebruary 2021 and 25th March 2021.ResultsWe approached a total of 34 EM ACFs. The survey yielded a 91% (n=31) response rate (13 current, 18 completed within 5 years). One university from Wales and ten from England have supported EM ACF schemes. 59% (n=10) of those who have completed the scheme had their clinical training extended to accommodate research time. In the remainder, fellows were expected to achieve clinical competencies in the same time as trainees who did not spend time on research. In those who had completed the ACF programme (n=18), one third of respondents are doing PhD training (n=6) and one is an academic clinical lecturer.ConclusionWe found variation in how the schemes are implemented. Future research is required to explore the experiences of those undertaking EM ACFs in more detail to identify the features of successful ACF training schemes, and whether any aspects may benefit from standardisation.

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Lee, Shauna A., and Mark D. Baker. "Erratum to “Analysis of DNA repair and recombination responses in mouse cells depleted for Brca2 by SiRNA” [DNA Repair 6 (2007) 809–817]." DNA Repair 6, no. 10 (October 2007): 1556. http://dx.doi.org/10.1016/j.dnarep.2007.05.006.

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Lisek, Anna, and Jerzy Lisek. "ASSESSMENT OF GENETIC DIVERSITY AND RELATIONSHIPS AMONG GRAPEVINE CULTIVARS ORIGINATING IN CENTRAL AND EASTERN EUROPE AND NORTH AMERICA USING ISSR MARKERS." Acta Scientiarum Polonorum Hortorum Cultus 18, no. 5 (October 29, 2019): 141–52. http://dx.doi.org/10.24326/asphc.2019.5.14.

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The study shows genetic diversity of 38 Vitis vinifera L. cultivars and hybrids originating in North America and Europe, including cultivars selected in Poland, which have not been characterized with the use of DNA markers yet. The agrobiological features of the genotypes selected for testing, indicate that they may be useful for the breeding of new cultivars and grape production. The use of 12 ISSR primers allowed to obtain 94.4% of polymorphism. The polymorphic information content (PIC) value was high and varied between 0.829 and 0.953 with an average of 0.897. The resolving power (Rp) ranged between 3.678 and 8.892 with an average of 6.347. Primers UBC 809, UBC 810, UBC 812, UBC 855, UBC 891 and UBC 810 were found to be highly effective (informative). Similarity coefficient ranged between 0.167 and 1.0, which indicates high degree of diversity of tested grape cultivars. Tested cultivars were grouped in 3 main clusters; one of them was further divided into 6 subclusters. ‘Pannonia Kincse’ and ‘Danmarpa Polonia’ were not differentiated. Phenotypic differences among those two cultivars suggest that ‘Danmarpa Polonia’ might be a clone of ‘Pannonia Kincse’ and other molecular techniques must be used to differentiate them. Morphological and agrobiological characters of cultivars support the results obtained by ISSR markers.

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Filipovic, Jelena, Shahin Ahmetxhekaj, Vladimir Filipovic, and Milenko Kosutic. "Spelt pasta with increased content of functional componets." Chemical Industry and Chemical Engineering Quarterly 23, no. 3 (2017): 349–56. http://dx.doi.org/10.2298/ciceq160208049f.

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This paper investigates the effects of addition of flax seed, sesame seed, or eggs (10 g/100 g of sample and 20 g/100 g of sample) in spelt flour to obtain new pasta products with improved ?-3/?-6 ratio and minerals profile. Gas chromatography with mass spectrometry was used for carrying out a quantitative analysis of the liposoluble pasta extract. Post-hoc Tukey?s HSD test at 95% confidence limit showed significant differences between observed samples. Daily average consumption of 75 g of spelt pasta containing 20 g flax seed/100 g of sample contributes to essential fatty acids intake of 3.8 g and improved ?-6/?-3 ratio (1:2.4). The obtaind results indicate that the investigated spelt pasta samples are new products with improved nutritional properties due to higher level of ?-3 fatty acids and minerals content (Ca, Zn, Cu and Fe). Pasta (PS 7) with 20 g/100 g of eggs has the best sensory quality (maximum scores for odor, texture, flavor and overall acceptability were 8.8, 8.9, 8.9 and 8.9, respectively).

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Ciombor, Kristen Keon, Jennifer Whisenant, Dana Backlund Cardin, Laura Williams Goff, Satya Das, Michael Schulte, Allison Cohen, et al. "CB-839, panitumumab, and irinotecan in RAS wildtype (WT) metastatic colorectal cancer (mCRC): Phase I results." Journal of Clinical Oncology 37, no. 4_suppl (February 1, 2019): 574. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.574.

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574 Background: Epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) are approved in RAS WT mCRC; however, patients (pts) will develop resistance to these agents. Alterations in glutamine (Gln) metabolism play a critical role in cancer cell growth. In cancers such as CRC, EGFR and Gln cooperate to provide signals and fuel for mitogen activated protein kinase-dependent cell growth. Our in vitro data show that Gln abrogates EGFR inhibition, and blockade of Gln transport restores sensitivity. We also observed a greater antitumor response in vivo with EGFR mAb plus CB-839, an inhibitor of a rate-limiting enzyme of Gln metabolism, than either agent alone. We designed a phase I/II study (NCT03263429) to evaluate CB-839 + panitumumab + irinotecan in anti-EGFR refractory RAS WT mCRC. Methods: Dose escalation used a Bayesian continual reassessment method targeting a 25% toxicity probability. CB-839 (600 mg or 800 mg twice daily [BID]) were evaluated with panitumumab (6 mg/kg) and irinotecan (180 mg/m2). Irinotecan was included in phase I to establish a future phase II dose of the triplet. Prior EGFR mAb treatment (tx) was not required for phase I. Dose-limiting toxicity (DLT) was any tx-related non-hematologic ≥Gr 3 toxicity (except fatigue, rash, or elevated liver enzymes) or ≥Gr 4 hematologic toxicity during the first 28 days. Results: Nine pts have been enrolled; 2 were not evaluable for DLT and replaced. Zero DLTs were observed at dose level 1 (n = 3) or 2 (n = 4); 2 more pts are needed to confirm the maximum tolerated dose (MTD). Most frequent toxicities were anemia and hypomagnesemia (88%) and elevated alkaline phosphatase, nausea, and rash (75%), most ≤Gr 2. One of 7 evaluable pts (14%) has an ongoing partial response, and 5 pts had stable disease (SD; 71%). Three pts have been on tx > 6 months, and 3 pts with prior EGFR mAb tx achieved SD. Conclusions: Triplet combination was tolerable at full doses of each drug, and preliminary antitumor activity was observed in a majority of pts. Phase II will begin after phase I completion and will evaluate efficacy of CB-839 (800 mg BID) and panitumumab (6 mg/kg). Imaging studies using investigational PET tracers to evaluate Gln metabolism as a function of tumor response are planned. Clinical trial information: NCT03263429.

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Zhu, Qin, Yu Min Zhang, Jin Zhang, Zhong Qi Zhu, and Qing Ju Liu. "High Response and Selectivity Methanol Gas Sensor Using Molecular Imprinting Technique." Materials Science Forum 809-810 (December 2014): 731–36. http://dx.doi.org/10.4028/www.scientific.net/msf.809-810.731.

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A new gas sensor with high response and selectivity was fabricated by using molecularly imprinted powders (MIPs) which provide special recognition sites to methanol. The MIPs were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and fourier transform infrared spectrometer (FT-IR), respectively. The gas sensing properties of MIPs to methanol were investigated. The experimental results indicate that the sensors based on the MIPs show excellent gas sensing properties to methanol vapor, and the properties of the sensor with x=6:10 (x= methyl acrylic acid: LaFeO3, molar ratio) are the best. At the optimal operating temperature of 130°C, the response of the sensor (x=6:10) to 1 ppm methanol is 21, and the response and recovery times are 57 s and 67 s, respectively.

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Miyamoto, T., T. Horie, T. Shimada, M. Kuwamura, and E. Baba. "Long-term case study of myelodysplastic syndrome in a dog." Journal of the American Animal Hospital Association 35, no. 6 (November 1, 1999): 475–81. http://dx.doi.org/10.5326/15473317-35-6-475.

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A 10-year-old, female shih tzu was diagnosed as having myelodysplastic syndrome (MDS) based on the presence of a nonregenerative anemia, dysplastic changes in the three hematopoietic cell lines, a normal to hypercellular bone marrow, and less than 30% blast cells of all nucleated cells in the bone marrow. Low-dose aclarubicin, a differentiation-induction therapy for MDS and atypical leukemias in humans, was administered. Hematological improvement was observed, and the dog lived for 809 days after the first presentation.

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Rossato, Sandro, Anna Carraro, Giovanni Monegato, Paolo Mozzi, and Fabio Tateo. "Glacial dynamics in pre-Alpine narrow valleys during the Last Glacial Maximum inferred by lowland fluvial records (northeast Italy)." Earth Surface Dynamics 6, no. 3 (September 26, 2018): 809–28. http://dx.doi.org/10.5194/esurf-6-809-2018.

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Abstract. During the Last Glacial Maximum (LGM), most of the major glaciated basins of the European Southern Alps had piedmont lobes with large outwash plains; only a few glaciers remained within the valley. Piedmont glaciers have left well-preserved terminal moraines, which allow for investigations to be carried out and inferences to be made regarding their evolution and chronology. Valley glaciers' remnants, on the contrary, are often scantly preserved, and changes can only be detected through correlations with glaciofluvial deposits in downstream alluvial basins. The Brenta glacial system's dynamics in the glacier's terminal tract have been inferred through a wide range of sediment analysis techniques on an alluvial stratigraphic record of the Brenta megafan (northeast Italy), and via the mapping of in-valley glacial/glaciofluvial remnants. Glaciers flowing across narrow gorges could possibly be slowed/blocked by such morphology, and glacial/sediment fluxes may then be diverted to lateral valleys. Moreover, narrow valleys may induce glaciers to bulge and form icefalls at their front, preventing the formation of terminal moraines. The Brenta Glacier was probably slowed/blocked by the narrow Valsugana Gorge downstream of Primolano and was effectively diverted eastwards across a wind gap (Canal La Menor Valley), joining the Cismon/Piave glaciers near Rocca and ending ∼2 km downstream. The Cismon and Piave catchments started to contribute to the Brenta system just after 27 ka cal BP until at least ∼19.5 ka cal BP. After the glaciers collapsed, the Piave River once again flowed into its main valley, whilst the Cismon continued to merge with the Brenta. This investigation shows that glacial catchments may vary significantly over time during a single glaciation in rugged Alpine terrains. Sand petrography and the chemical/mineralogical composition of sediments are powerful proxies for tracing such variations, as they propagate through the glacial and glaciofluvial systems and can be recognized in the alluvial stratigraphic record far downstream from the glacier front.

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谢, 志辉, 林根陈 та 丰瑞孙. "基于热流与强度复合目标的立式绝热壁构形优化". SCIENTIA SINICA Technologica 41, № 6 (1 травня 2011): 809–20. http://dx.doi.org/10.1360/ze2011-41-6-809.

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43

Rodríguez-Riaño, Tomás, Ana Ortega-Olivencia, and Juan A. Devesa. "Reproductive biology in two Genisteae (Papilionoideae) endemic of the western Mediterranean region: Cytisus striatus and Retama sphaerocarpa." Canadian Journal of Botany 77, no. 6 (1999): 809–20. http://dx.doi.org/10.1139/cjb-77-6-809.

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Ryzhkov, Alexander V., Terry J. Schuur, Donald W. Burgess, Pamela L. Heinselman, Scott E. Giangrande, and Dusan S. Zrnic. "The Joint Polarization Experiment: Polarimetric Rainfall Measurements and Hydrometeor Classification." Bulletin of the American Meteorological Society 86, no. 6 (June 2005): 809–24. http://dx.doi.org/10.1175/bams-86-6-809.

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松本, 晃治, 冬彦菊池, 英夫花田, Goossens Sander, 劲松平, 晓瑜洪, 广利王, 庆会刘, 为民郑 та 明. 陈. "同波束VLBI在采样返回式多目标探测器精密测轨测位中的应用†". SCIENTIA SINICA Physica, Mechanica & Astronomica 40, № 6 (1 червня 2010): 809–18. http://dx.doi.org/10.1360/2010-40-6-809.

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汪, 国昭, 静静于 та 平. 朱. "C-B- 样条曲线的升阶算子与几何生成法". SCIENTIA SINICA Informationis 40, № 6 (1 червня 2010): 809–20. http://dx.doi.org/10.1360/zf2010-40-6-809.

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Botticella, G., M. Pizzonia, B. Cossu, R. Bruno, D. Camellino, G. Girasole, A. Giusti, et al. "POS1105 EFFECTS OF CHOLECALCIFEROL AND CALCIFEDIOL IN OSTEOPOROTIC WOMEN WITH SECONDARY HYPERPARATHYROIDISM DUE TO SEVERE VITAMIN D DEFICIENCY UNDERGOING ZOLEDRONIC ACID TREATMENT: A RANDOMIZED-CONTROLLED TRIAL." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 833.1–833. http://dx.doi.org/10.1136/annrheumdis-2021-eular.809.

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Background:Secondary hyperparathyroidism (sHPTH) due to vitamin D deficiency impairs the bone mineral density (BMD) response to alendronate,1-2 but the optimal strategy for its correction in postmenopausal osteoporotic women (PMO) about to start zoledronic acid (ZOL) therapy is still unknown.Objectives:To evaluate the effects of cholecalciferol (D3) and calcifediol (25OHD) on serum 25-OH-vitamin D (s25OHD), parathyroid hormone (PTH) and BMD in PMO presenting with sHPTH due to vitamin D deficiency.Methods:PMO with s25OHD <20 ng/ml, sHPTH (PTH >65 pg/ml) and BMD T-score at the lumbar spine (LS), femoral neck (FN) or total hip (TH) < -2.5, or between -1 and -2.5 plus one vertebral/femoral fracture, were randomly assigned to receive a therapeutic dose of D3 (300.000 IU bolus) followed by 175 mcg/weekly of D3, or 175 mcg/weekly of 25OHD alone, 2 months before receiving a single intravenous infusion of ZOL (5 mg). BMD at the LS, FN and TH was assessed at baseline and after one year from ZOL. Serum calcium, PTH and s25OHD were measured at baseline, and 6- and 12-month after ZOL. Adverse and clinical events were ascertained by 3-and 9-month telephone interviews, and by 6- and 12-month clinical evaluation.Results:45 PMO (25OHD N=23, D3 N=22) were enrolled over one year and 32 subjects (mean age ±SD 75±10 years, range 51-91) completed the 1-year of treatment/follow-up (25OHD N=17, D3 N=15). Most PMO discontinued for protocol violation, while three deceased before study ending (25OHD N=1, D3 N=2) for reasons not related to the agents investigated. The baseline characteristics were comparable in both groups. At baseline mean s25OHD (±SE) was 8±1 ng/ml in the 25OHD group and 8±1 ng/ml in the D3 group. The corresponding figures for PTH were 111±6 pg/ml (25OHD) and 117±5 pg/ml (D3). Mean s25OHD (±SE) increased in both groups at 6- and 12-month, being significantly greater in the 25OHD group (12-month, 56±2 ng/ml) compared to the D3 group (12-month, 34±2 ng/ml, P<.001) at both time points (Figure 1). PTH (mean ±SE) decreased in both groups, being significantly lower in the 25OHD group at 12-month (25OHD 46±6 pg/ml versus D3 70±6 pg/ml, P=.007), as shown in Figure 1. BMD at the LS, FN and TH increased in both groups (with significant increases versus baseline only at the FN) without significant differences between s25OHD and D3. In PMO receiving D3 serum calcium remained stable over time, while those receiving s25OHD demonstrated a significant increase of serum calcium, with 2 PMO presenting a value close to the upper limit of the reference range at 12-month. No patient reported incident fractures or adverse events.Conclusion:Calcifediol 175 mcg weekly appears more potent in improving s25OHD and decreasing PTH concentrations compared to cholecalciferol therapeutic dose (300’000 IU) plus 175 mcg weekly in PMO presenting with sHPTH due to severe vitamin D deficiency about to start ZOL therapy. Further studies are warranted to clarify implications on BMD improvements on the long-term of similar 25OHD and D3 regimens.References:[1]Barone A et al., J Am Geriatr Soc 2007.[2]Kincse G et al., BMC Musculoskelet Disord 2012.Disclosure of Interests:Giulia Botticella: None declared, Monica Pizzonia: None declared, Barbara Cossu: None declared, Roberta Bruno: None declared, Dario Camellino Speakers bureau: AbbVie, Celgene, Janssen-Cilag, Eli Lilly, Medac, Mylan, Novartis, and Sanofi, outside the submitted work, Giuseppe Girasole Speakers bureau: Abiogen Pharma and Novartis, outside the submitted work, Andrea Giusti Speakers bureau: UCB, Amgen, Kyowa Kirin, Abiogen Pharma, and Eli Lilly, outside the submitted work, Consultant of: EffRx and Abiogen Pharma, outside the submitted work, Mario Pedrazzoni: None declared, Simona Alexovits: None declared, Franco Pleitavino: None declared, Federico Santolini: None declared, Alessio Nencioni: None declared, Gerolamo Bianchi Speakers bureau: Abbvie, Abiogen Pharma, Amgen, BMS, Celgene, Eli Lilly, GSK, Janssen-Cilag, Medac, MSD, Novartis, Pfizer, Roche, Sanofi, Genzyme, and Servier, outside the submitted work.

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Pascu, Cristina Ileana, Iulian Popescu, and Alexandru Vintilescu. "Research about Surface Quality of Polytetrafluoroethylene (Teflon) after Inner Turning ." Applied Mechanics and Materials 809-810 (November 2015): 213–19. http://dx.doi.org/10.4028/www.scientific.net/amm.809-810.213.

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For this study with high originality, a teflon bushing with outer diameter of 58 mm and 32 mm internal diameter has been turned. After inner turning with various cutting feeds, the part has been cut in half to measure roughness. The roughness parameters Ra, Rz and Rq have beeen measured with an electronic roughness tester Mitutoyo, Japan, SJ-201 P. The micro-asperity images for each of the 6 samples performed are presented in the paper. Diagrams with the variations of roughness parameters are also given in this study. The trend is the increasing of roughness values with feed increasing, but some abnormalities also appear in samples 3 and 4 for Ra and Rz. At sample 5 for Rz parameter and sample 6 for Rq parameter a decreasing of values occurs, although geometrically there should be with ascending tendencies. It follows that in teflon turning the cutting process is not uniform, although there are no marks on the blade. However, because this material is not metallic, it does not have a uniform structure, which influences the resulted roughness. This is the cause of the anomalies established by these experiments.

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Dams, Judith, Klaus-Thomas Kronmüller, Eric Leibing, Regina Steil, Peter Henningsen, Falk Leichsenring, Hamid Peseschkian, et al. "Direkte Kosten sozialer Angststörung bei Jugendlichen und Kosteneffektivität der Psychotherapie." Psychiatrische Praxis 46, no. 03 (October 31, 2018): 148–55. http://dx.doi.org/10.1055/a-0733-4999.

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Zusammenfassung Hintergrund Ziel war die Analyse direkter Kosten sozialer Angststörung (SAD) bei Jugendlichen und der Kosteneffektivität von CBT bzw. PDT. Methoden Multizentrische randomisierte Studie mit N = 103 Patienten. Krankheitskosten wurden zur Baseline und Kosteneffektivität nach der Behandlung analysiert. Ergebnisse Direkte 6-Monats-Kosten zu Baseline lagen bei 809 €. Während die inkrementelle Kosten-Effektivitäts-Relation von CBT im Vergleich zur Warteliste bei 18 824 €/QALY lag, war PDT nicht kosteneffektiv. Zusammenfassung SAD verursacht hohe direkte Kosten. CBT ist wahrscheinlich kosteneffektiv.

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Chaudhry, Nimra, Eris Cani, Lendelle Raymond, Tae Park, and Timothy Kanter. "893. Evaluating Weight Gain in Treatment-naïve, HIV-infected Patients Started on Antiretroviral Therapy." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S538. http://dx.doi.org/10.1093/ofid/ofab466.1088.

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Abstract Background There is increasing evidence that integrase strand transfer inhibitors (INSTIs) are associated with more weight gain when compared to other antiretroviral (ART) classes. Thus, the primary objective of the study was to evaluate the difference in weight gain at 6 and 18 months among treatment-naïve patients started on an INSTI-based versus a non-INSTI-based ART regimen. Methods This was a retrospective cohort study of ART-naive adults who were initiated and maintained on INSTI and non-INSTI based regimens for at least 18 months at an HIV clinic in an inner-city hospital from January 2013 to June 2019. The non-INSTI-based regimens were darunavir (DRV) or rilpivirine (RPV)-based. Data collected included patient demographics, ART regimen, pre- and post-ART initiation weight in kilograms (kg), body mass index (BMI), CD4 count, and viral load. A two-tailed t-test was used to compare change in weight in INSTI-based versus non-INSTI-based regimens. Sub-group analyses were conducted using the ANOVA test. Results Out of 170 patients, 60% were initiated on an INSTI-based regimen, 7.1% on a DRV-based regimen, and 32.9% on a RPV-based regimen. Of the patients initiated on INSTI-based regimens, 73.5% were on elvitegravir (EVG),16.7% on dolutegravir, 8.8% on bictegravir, and 0.98% on raltegravir. The mean age at ART initiation was 38 years with majority of the patients described as Black. More male patients received an INSTI-based regimen compared to females (77.5% vs. 32%). The average change in weight at 6 and 18 months in the INSTI-based group vs non-INSTI-based group was +3.6 kg vs. +2.9 kg (95% CI -2.2-0.7, p=0.317) and +5.7 kg vs.+4.8 kg (95% CI -3.2-1.2, p=0.357) respectively. There was no significant average change in weight among the INSTI-based regimens (+3.6 kg), vs DRV (+5.3 kg), or RPV (+2.4 kg) based regimens at 6 months (p=0.108) and 18 months [(+5.7 kg) vs (+7.2 kg), vs (+4.3 kg) (p=0.186) respectively]. Among the INSTIs, EVG was associated with the highest increase in weight at both 6 and 18 months (+3.9 kg and +5.8 kg). Forty-six percent of patients in the INSTI group were on tenofovir alafenamide (TAF) while no patients received TAF in the non-INSTI groups. Conclusion When comparing INSTI-based to DRV or RPV-based regimens, there was no significant increase in average weight at 6 and 18 months. Disclosures All Authors: No reported disclosures

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