Добірка наукової літератури з теми "794.801 4"

Основываясь на проведенных ранее исследованиях, были использованы данные, полученные в процессе сбора и анализа статистических данных. Определены внешние и внутренние факторы, влияющие на систему. Рассмотрены методы прогнозирования, оптимально подходящие для решения задач, стоящих перед предприятием лакокрасочной отрасли. С помощью метода анализа иерархий был проведен анализ альтернативных методов прогнозирования. На основании выводов, полученных в результате анализа, были выбраны нейросетевые модели. В статье рассмотрены результаты проведенной серии экспериментов по прогнозированию выпуска продукта НЦ-132 (Выбор мастера) с помощью нейросетевых моделей. По результатам экспериментов предложена схема выбора нейросетевой модели и алгоритм ее предварительного обучения. Приведены результаты проведенных экспериментов, на основании которых в дальнейшем планируется описание функционала модуля прогнозирования, разработки технического задания и внедрения разработанной системы.

RESUMEN:El objetivo del artículo es aproximarnos a la controvertida biografía del comisario Manuel Brabo Portillo. El trabajo está basado en fuentes primarias y secundarias. El método utilizado es empírico. En el imaginario del mundo sindicalista revolucionario, Brabo Portillo era el policía más odiado, la reencarnación de la cara más turbia del Estado. Fue, así mismo, un espía alemán relacionado con el hundimiento de barcos españoles, el asesinato del empresario e ingeniero Barret y el primer jefe de los terroristas vinculados a la patronal barcelonesa. La conflictividad que afectó a España en el período de la Primera Guerra Mundial es fundamental para entender los orígenes del terrorismo vinculado al pistolerismo, que marcó la historia político social española del primer tercio del siglo XX.PALABRAS CLAVE: Brabo Portillo, pistolerismo, espionaje, sindicalismo, Primera Guerra Mundial.ABSTRACT:The objective of the article is an approach to the controversial biography of Police Chief Manuel Brabo Portillo. The work is based on primary and secondary sources. The method used is empirical. In the imagery of the revolutionary syndicalist world, Brabo Portillo was the most hated policeman, the reincarnation of the murkiest face of the state. He was also a German spy connected with the sinking of Spanish ships, the murder of businessman and engineer Josep Barret and the first head of the terrorists linked to Barcelona employers. The conflict that affected Spain during the period of the First World War is fundamental in order to understand the origins of terrorism linked to pistolerismo, which marked Spanish social political history during the first third of the twentieth century.KEY WORDS: Brabo Portillo, pistolerismo, espionage, syndicalism, First World War. BIBLIOGRAFÍAAisa, M., La efervescencia social de los años 20. Barcelona 1917-1923, Barcelona, Descontrol, 2016.Aguirre de Cárcer, N., La neutralidad de España durante la Primera Guerra Mundial (1914-1918). I. Bélgica, Madrid, Ministerio de Asuntos Exteriores, 1995.Alonso, G., “’Afectos caprichosos’: Tradicionalismo y germanofilia en España durante la Gran Guerra”, Hispania Nova, 15, 2017, pp. 394-415.Amador, A., El Terror blanco en Barcelona. Las bombas y los atentados personales. Actuación infernal de una banda de asesinos al servicio de la burguesía. El asesinato como una industria, Tarragona, Talleres gráf. 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Two excavations within the medieval burgh provided the opportunity to investigate an early industrial zone on the western side of Meal Vennel and a relatively rich undeveloped area in the backlands of Scott Street. The artefact rich Meal Vennel excavation revealed evidence of a possible early western boundary of the town, timber and stone buildings and industrial activities including grain drying and iron smithing. Backland activities including sand quarrying, the digging of rubbish pits and dumping of midden, were investigated at Scott Street. A number of questions relating to the medieval development of Perth were addressed. `Excavations at Meal Vennel' by Richard Sermon & Adrian Cox (736--51), including: `The pottery' by Peter Cheer (753--9); a gold and sapphire ring and the copper alloy objects including dress fasteners/fittings and keys, a mount and fittings, needles, padlock components, pendants, pins, rivets, seal matrix, sheets and strips, thimbles and tweezers; lead alloy objects; iron objects including arrowheads, buckles, horse equipment, household ironwork, and knives are detailed along with a `Metallurgy of the knives' by Paul Harrison (776--7), locks and keys, structural ironwork, and tools; stone objects; bone and antler objects including perforated bones and horn cores, horn-working evidence, pins, antler offcuts; the glass including a bead, linen smoother(?) and window glass; `Coins and a jetton' by Nicholas Holmes (789--90); `The flint' by Jill Harden (790 & 791); ceramic roof tiles; industrial residues; `The leather' by Clare Thomas (792); `The animal bone' by Catherine Smith (792--4); and `Botanical remains' by Alan Fairweather (795). `Excavations at Scott Street' by Jonathan Burrows (795--801) is followed by the specialist reports from that site including: `The pottery' by Peter Cheer (801--4); copper alloy objects; lead alloy objects; iron objects; stone objects; the wooden cask; `Textiles' by Thea Gabra-Sanders (810--11); ceramic floor tiles; glass; clay pipes; `Coins' by Nicholas Holmes (812); `Mammal and bird bone' by Catherine Smith (812--13); `Botanical remains' by Alan Fairweather (813--14).

Background: Two billion U.S. healthcare dollars are spent on youth sports injuries each year. This staggering figure is projected to increase as athletes are sustaining more sport-related injuries and are specializing in a single sport at younger ages than ever before. Sport specialization is a modifiable injury risk factor unique to youth athlete populations. Parents are a group of key stakeholders whose knowledge and beliefs likely impact youth sport participation, however a paucity of research exists in this area. Purpose: To assess the differences in perceptions of parents on youth sport participation and specialization based on geographical region. Methods: Parents of children, ages 8-18 years, who participate in organized sports were surveyed for this study. Electronic surveys with a total of 40 questions were circulated via team/organization mailing lists and social media. Geographic regions were described as either South or North based on divisions from the U.S. Census Bureau. Sport specialization was defined as an athlete meeting >2 of the following 3 criteria: participates in one sport to the exclusion of other sports, participates in sport-specific lessons, participates on >2 teams in a single sport. Descriptive statistics and chi-square analyses were used to compare perceptions of parents with specialized and non-specialized athletes across different geographical regions. Results: Three-hundred and seventy-one responses were collected (South=204, North=167). Parents from the South reported a higher number of specialized athletes as compared to parents from the North (54% vs 38%; P=0.003). Regardless of geographical region, most parents did not think specialization had a positive impact on a youth athlete’s development ( P=0.307) or their future in that sport ( P=0.086) (Figures 1 & 2). Parents from the South did select ‘Potential to earn a college scholarship’ as a motivator for youth sport specialization more often when compared to parents from the North (30% vs 17%; P=0.002). Conclusion: Regional differences exist in the percentage of specialized youth athletes participating in organized sport. Parental knowledge of the risks and benefits of youth sport specialization does not appear to drive these observed differences. Earning a college scholarship was selected more frequently as a reason for specialization in the South, indicating that societal or socioeconomic factors may be present. Further research is needed to determine the underlying factors driving youth sport specialization in the U.S. Figures: [Figure: see text][Figure: see text] References: Bell DR PE, Trigsted SM, Hetzel S, McGuine TA and Brooks MA. Prevalence of Sport Specialization in High School Athletics: A 1-Year Observational Study. Am J Sports Med. 2016;44(6):1469-1474. Bell DR, Post EG, Trigsted SM, Schaefer DA, McGuine TA, Brooks MA. Parents’ Awareness and Perceptions of Sport Specialization and Injury Prevention Recommendations. Clin J Sport Med. 2018. Brooks MA, Post EG, Trigsted SM, et al. Knowledge, Attitudes, and Beliefs of Youth Club Athletes Toward Sport Specialization and Sport Participation. Orthop J Sports Med. 2018;6(5). Gregory S. How Kids’ Sports became a $15 Billion Industry. TIME. 2017;190(9). Jayanthi NA, LaBella CR, Fischer D, Pasulka J, Dugas LR. Sports-specialized intensive training and the risk of injury in young athletes: a clinical case-control study. Am J Sports Med. 2015;43(4):794-801. LaPrade RF, Agel J, Baker J, et al. AOSSM Early Sport Specialization Consensus Statement. Orthop J Sports Med. 2016;4(4). Malina RM. Early sport specialization: roots, effectiveness, risks. Curr Sports Med Rep. 2010;9(6):364-371. McGuine TA, Post EG, Hetzel SJ, Brooks MA, Trigsted S, Bell DR. A Prospective Study on the Effect of Sport Specialization on Lower Extremity Injury Rates in High School Athletes. Am J Sports Med. 2017;45(12): 2706-2712. Myer GD, Jayanthi N, Difiori JP, et al. Sport Specialization, Part I: Does Early Sports Specialization Increase Negative Outcomes and Reduce the Opportunity for Success in Young Athletes? Sports Health.2015;7(5):437-442. Pasulka J, Jayanthi N, McCann A, Dugas LR, LaBella C. Specialization patterns across various youth sports and relationship to injury risk. Phys Sportsmed. 2017;45(3):344-352. Post EG, Trigsted SM, Riekena JW, et al. The Association of Sport Specialization and Training Volume With Injury History in Youth Athletes. Am J Sports Med. 2017;45(6):1405-1412. U.S. Census Bureau. Census Bureau Regions and Divisions with State FIPS Codes. https://www2.census.gov/geo/pdfs/maps-data/maps/reference/us_regdiv.pdf . Accessed June 26, 2020.

Fifteen 7,4’- O-modified genistein amino acid derivatives are synthesized through nucleophilic substitution and hydrolysis, followed by condensation with diverse amino acid esters. The antiproliferative activity of all the synthesized compounds is evaluated against three cancer cell lines (MGC-803, HeLa, HCT-116) and one normal cell line (HUVEC) using 5-fluorouracil (5-Fu) as the positive control. The results show that methyl [2-({5-hydroxy-3-[4-(2-{[3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]amino}-2-oxoethoxy)phenyl]-4-oxo-4 H-chromen-7-yl}oxy)acetyl] tyrosinate exhibits significant antiproliferative activity against the MGC-803 cell line with an IC50 value of 8.52 µM, and its inhibitory effects on HeLa and HCT-116 cancer cells are stronger than that of the positive control drug 5-Fu.

Wild-type and mutant chicken integrin beta 1 subunit (beta 1c) cDNAs were expressed in NIH 3T3 cells and assayed for localization in focal adhesions of cells plated on fibronectin substrates. Focal adhesion localization in stable transfected cells was assayed by indirect immunofluorescent staining with chicken-specific anti-beta 1c antibodies. Mutant beta 1c integrins containing internal deletions of 13 amino acids adjacent to the membrane, delta 759-771, and 20 centrally located amino acids, delta 771-790, localized in focal adhesions demonstrating that sequences required for direction to focal adhesion structures were not limited to one region of the cytoplasmic domain. Point mutations revealed three clusters of amino acids which contribute to localization in focal adhesions. These three clusters or signals are: cyto-1 (764-774), cyto-2 (785-788), and cyto-3 (797-800). The 11-residue cyto-1 signal is only found on integrin beta subunit sequences, except beta 4. Four residues within this region, D764, F768, F771, and E774, could not be altered without reducing focal adhesion staining intensities, and likely form a signal that occupies one side of an alpha helix. Mutations involving two cyto-1 residues, K770 and F771, also appeared to affect heterodimer affinity and specificity. Cyto-2 (785-788,), NPIY, is an NPXY signal that forms a tight turn motif. Cyto-2 provides a structural conformation, which when perturbed by proline removal or addition, inhibits integrin localization in focal adhesions. Cyto-3 (797-800), NPKY, resembles cyto-2, however, the nonconserved proline residue can be replaced without alteration of the localization phenotype. Cyto-3, therefore, constitutes a unique integrin signal, NXXY. Both serine and tyrosine residues at positions 790 and 788, respectively, which have been implicated in integrin phosphorylation/regulation, were conservatively replaced without detectable effect on focal adhesion localization. However, acidic replacements for these amino acids reduced focal adhesion staining intensities, suggesting that phosphorylation at these sites may negatively regulate integrin function.

Children as young as five have some ability to produce contrastive focus [Wells et al. (2004) J. Child Lang. 31, 749–778]. However, adult listeners' ability to identify the location of contrastive focus depends on whether the speech came from a 4-, 7-, or 11-year-old [Patel and Brayton (2009) J. Speech. Lang. Hear. Res. 52, 790–801]. Recent acoustic studies have also reported the use of F0 vs duration in contrastive focus productions by American English–speaking 2-year-olds [Thorson and Morgan (2021) J. Child Lang. 48, 541–568] and 4-year-olds [Wonnacott and Watson (2008) Cognition 107, 1093–1101], respectively. This study, therefore, evaluated the extent to which older 6-year-olds, with more language experience, used F0 and/or duration when producing contrastive focus, and compared this to adult speech. Monosyllabic and disyllabic adjective + noun targets (e.g., green ball) in utterance medial and final position were elicited from 20 Australian English–speaking 6-year-olds and 14 adults in adjective focus and noun focus conditions. Although both adults and children used high F0, only adults consistently used word and stressed syllable duration as well. This suggests that children may master the different acoustic cues to contrastive focus at different stages of development, with late cue integration.

Article 4(7) (Definitions) (see too recital 79); Article 5 (Principles relating to the processing of personal data) (see too recital 39); Article 24 (Responsibility of the controller) (see too recital 74); Article 28 (Processors) (see too recital 81); Article 82 (Right to compensation and liability) (see too recital 146).

The essay aims to present part of the poetic work of the Tang dynasty 唐朝 (618-907) poet Wei Qumou 韋渠牟 (749-801). Nineteen poems of the buxu 步虛 genre are translated here, representing almost entirely what has been handed down to us of his poetic production. This kind of poetry is distinguished by the theme: a description of the poet’s journey beyond the world of mortals, which ends by visiting the deities that reside in the constellation of Ursa Major, thanks to meditation, alchemical practices and knowledge of sacred texts.

This chapter evaluates Lebanese perspectives on the Hague Principles. In Lebanon, private international law rules in respect of international commercial contracts are not codified. There are statutory rules governing certain areas of private international law, some of which might be relevant in cases where international commercial contracts are litigated. This is the case for rules on international jurisdiction (Articles 74–80 Code of Civil Procedure, hereafter CCP), recognition and enforcement of foreign decisions (Articles 1009–1024 CCP), international arbitration (Articles 809–821 CCP) and the application of foreign law (Articles 139–142 CCP). Given the rarity of private international law statutory rules, and specifically the absence of statutory choice of law rules for international commercial contracts, it was up to the courts to shape conflict of law rules for these contracts.. In this respect, Lebanese courts do not have the authority to refer to the Hague Principles as persuasive applicable rules, ie to use them to interpret and supplement the applicable rules and principles of private international law. Nevertheless, it should be noted that Article 4 CCP invites the courts, in the absence of statutory law, to rely on ‘general principles, custom and equity’.

Abstract One of the great statesmen of the nineteenth century, William Ewart Glad­ stone was a distinguished orator, classical scholar, political writer, and leader of the Liberal Party. He served four terms as Prime Minister (1868-74, 1880-5, 1886, 1892-4), frequently clashing with his conservative rival Benjamin Disraeli (1804-81). As a student at Eton, he edited the Eton Miscellany, where this sonnet appeared.

Recitals 75–79; recital 88; Article 4(12) (Definition of a personal data breach); Article 28(1) (Choice of processor providing sufficient guarantees) (see too recital 81); Article 28(3)(c) (Processor must be contractually bound to implement security measures); Article 33 (Personal data breach notification requirement to the supervisory authority) (see too recitals 85 and 87); Article 34 (Communication of a personal data breach to the data subject) (see too recital 86).

This chapter describes the set up step series, developed by the Genoa Research Group on Production System Simulation at the beginning of the ’80s, as a sequence, through which it is possible at first statistically validate the simulator, then estimate the variables which effectively affect the different target functions, then obtain, through the regression meta-models, the relations linking the independent variables to the dependent ones (target functions) and, finally, proceed to the detection of the optimal functioning conditions. The authors pay great attention to the treatment, the evaluation and control of the Experimental Error, under the form of Mean Square Pure Error (MSPE), a measurement which is always culpably neglected in the traditional experimentation on the simulation models but, that potentially can consistently invalidate with its magnitude the value of the results obtained from the model.

Abstract Oatts, dick (richard dennis), alto, tnr saxes, cl, fl; b. Des Moines, IA, 4/2/53. Father, Jack, pioneered jazz educ. in Iowa; bro. Jim pl. w. Kenton, Thad Jones–Mel Lewis. Stud. w. fath., then for one yr. at Drake U. Pl. club dates fr. age 13. Freelanced in Minneapolis-St. Paul 1972–7 bef. moving to NYC. Pl. w. Thad Jones–Mel Lewis Orch. ’77–9; Mel Lewis Orch. and Qnt. ’79–90, then Vanguard Jazz Orch., Bob Brookmeyer ’81–4; Ray Mantilla ’82–6; Joe Haider ’82–91; Red Rodney ’86–90; Eddie Gomez ’87–91; Dial and Oatts w. Garry Dial since ’89; also pl. w. Tito Puente; Machito; Fred Hersch; Jack McDuff; Teo Macero; Joe Morello; Flora Purim. Taught at NYU ’81–4; Manh. Sch. of Mus. fr. ’91. Fav. arrs: Brookmeyer, Dial. Fests: Eur., Japan, So. Amer., etc. since ’77. TV: David Letterman. CDs: Steep.; Dial and Oatts (DMP); w. Mel Lewis (Tel.; M M); R. Rodney (Steep.; Den.); T. Talbert (Chart.); H. Meurkens; A. Farnham (Conc.); Bill Mays; Ted Rosenthal (JA); Gary Smulyan (CC); Vic Juris (Steep.); A Donelian (Sunny.); Stockholm Jo (Drag.).

This work investigated waste plastic pyrolysis oil (WPPO), 2-ethyl hexyl nitrate (EHN), and ethanol as sources of renewable energy, blending conventional diesel (CD), WPPO, and ethanol with EHN was to improve the combustion and performance characteristics of the WPPO blends. EHN has the potential to reduce emissions of CO, CO2, UHC, NOX, and PM. Ethanol improves viscosity, miscibility, and the oxygen content of WPPO. Mixing ratios were 50/WPPO25/E25, 60/WPPO20/E20, 70/WPPO15/E15, 80/WPPO10/E10, and 90/WPPO5/E5 for CD, waste plastic pyrolysis oil, and ethanol, respectively. The mixing ratio of EHN (0.01%) was based on the total quantity of blended fuel. Performance and emission characteristics of a stationary 4-cylinder water-cooled diesel Iveco power generator were evaluated with ASTM standards. At 1000 rpm, the BSFC was 0.043 kg/kWh compared to CD at 0.04 kg/kWh. Blend 90/WPPO5/E5 had the highest value of 14% for BTE, while the NOX emissions for 90/WPPO5/E5, 80/WPPO10/E10, and 70/WPPO15/E15 were 384, 395, and 414 ppm, respectively, compared to CD fuel at 424 ppm. This is due to their densities of 792 kg/m3, 825 kg/m3 which are close to CD fuel at 845 kg/m3 and the additive EHN. These results show blends of WPPO, ethanol and EHN reduce emissions, and improve engine performance, mimicking CD fuel.

Most work on erbium-doped fiber amplifiers (EDFA) over the past few years has focussed on amplifiers pumped at 980 nm and at 1480 nm.1-3 Recently, however, there has been renewed interest for file 800-nm pump band.4 In this paper we present a comparative study of an EDFA pumped by a Ti:sapphire laser tuned to both 800 and 980 nm in order to illustrate the effects of excited-state absorption.5 The erbium-doped fiber used in the experiment has a 4-μm-diameter SiO2-Al2O3-GeO2 core with a relative index difference of 0.035 and a cutoff wavelength of ~815 nm. The erbium concentration is 200 ppm. Gain and saturation measurements were per formed on different lengths of fiber, pumped at 980 nm and at some arbitrary wavelength in the 810-nm region, the optimum wavelength having been found to increase with length. Figure 1 is a plot of normalized gain for λs = 1533 nm as a function of pump wavelength. The 3-dB bandwidth is 14 nm. The peak gain for this 12-m piece is obtained for λ p = 811 nm and was 25 dB for λ s = 1533 nm and 20 dB for λ s = 1553 nm. The maximum absorption, however, was found to be at 797 nm.

The flexural strength of a commercially available sintered silicon nitride (NGK-SN73) material containing various oxide additives (ceria, magnesia, zirconia and SrO) was determined in 4-point bending as a function of temperature (20 to 1200 C) in an air environment. Significantly, high strength (790 MPa) is maintained from room temperature to 800 C. At 900 C. and above, flexural strength decreased sharply. The sudden decrease in strength at temperatures of 900 and 1000 C is believed due to softening of the residual glass phase present in the material, and led to the presence of sub-critical crack growth. The extent of sub-critical crack growth and large viscous flow increased with increasing temperature (1100–1200 C) and led to degradation of material’s strength. In addition, the material was susceptible to oxidation at these temperatures as displayed by discoloration (dark gray to white) of the specimens. Extensive flexural stress rupture testing was carried out in the temperature range 800 to 1000 C in order to determine (i) the material’s susceptibility for low temperature oxidation instability, (ii) the presence of sub-critical crack growth at low temperatures (700 to 800 C) and high temperatures (900 to 1000 C) and (iii) to identify allowable stress levels for limited time (≤ 100 h) without showing degradation of materials strength (failure, creep or oxidation). Detailed fractographic evidence is presented to illustrate the type of strength controlling flaws present in the material at 20 C and above, and to reveal the presence of sub-critical crack growth displayed by the material in the temperature range 800 to 1000 C under stres-rupture mode.

ЦЕЛЬ: изучить основные эпидемиологические и клинические характеристики первичного гиперпара- тиреоза (ПГПТ) по данным всероссийского регистра. МАТЕРИАЛЫ И МЕТОДЫ: объектом исследования являются пациенты с ПГПТ, данные которых внесены в электронную информационно-аналитическую базу регистра (http://pgpt.clin-reg.ru/) с возможностью он- лайн-доступа на всей территории Российской Федерации (РФ). Анализ проводился 12.01.2023 г. по данным последнего визита пациента, внесенного в регистр, независимо от его давности. РЕЗУЛЬТАТЫ: общее количество пациентов составило 6003 чел. (женщины/мужчины 11,7/1) из 81 ре- гиона РФ. Активная фаза заболевания зарегистрирована у 61% пациентов (3681/6003). Среди них в 74% (2717/3681) случаев отмечена симптомная форма ПГПТ, бессимптомная - в 26% (964/3681). Сочетание костных и висцеральных осложнений заболевания выявлено в 37% (1017/2717), а изолированные вис- церальные и костные нарушения - в 20% (536/2717) и 32% (861/2717), соответственно. Пациенты с сим- птомной формой заболевания имеют значимо более высокие показатели ПТГ и кальция крови, а также суточной кальциурии по сравнению с лицами с бессимптомным течением – медиана ПТГ 131,0 [84,6; 218,0] vs 112,0 пг/мл [84,0; 157,0]; общего кальция 2,72 [2,60; 2,88] vs 2,66 ммоль/л [2,53; 2,77], альбумин-скоррек- тированного кальция 2,68 [2,57; 2,83] vs 2,61 ммоль/л [2,50; 2,71], ионизированного кальция 1,35 ммоль/л [1,26; 1,45] vs 1,30 ммоль/л [1,21; 1,38], суточной кальциурии 7,16 [4,64; 9,90] vs 6,79 [5,02; 9,48] (p<0,001, U-тест, поправка Бонферрони Р0=0,008). Обращает на себя внимание низкая частота расчета альбумин- скорректированного кальция крови (только у 23% (1406/6003) пациентов), несмотря на то, что имеется автоматический расчет данного показателя при внесении результатов общего кальция и альбумина. Хирургическое лечение ПГПТ проведено у 53% (3215/6003) пациентов, среди них аденома диагно- стирована в 84%, гиперплазия - в 9%, карцинома околощитовидных желез - в 4% случаев (90/3215), ати- пическая аденома - в 2% (53/3215). Ремиссия заболевания после хирургического лечения установлена у 55% (1758/3215) пациентов, рецидив – у 13%. Подозрение на наследственный характер ПГПТ имеют 13% пациентов (805/6003), из них генетическое подтверждение получено в 171 случаях (21%), с наличием герминальных мутаций в генах MEN1 у 107 пациентов, CDC73 – у 6 и RET – у 2 человек. ВЫВОДЫ: в РФ преобладает симптомная форма ПГПТ с выраженными нарушениями фосфорно-каль- циевого обмена. При этом в большинстве случаев заболевание обусловлено доброкачественными обра- зованиями ОЩЖ. По данным проведенного анализа альбумин-скорректированный кальций определялся только в 23% случаев, тогда как расчет данного показателя необходим для исключения ложных отклонений уровня кальция крови при изменении концентрации плазменных белков. Повышение выявляемости ПГПТ в РФ имеет приоритетное значение для улучшения качества оказания медицинской помощи пациентам с данной патологией.

Abstract Medco E&P Indonesia (Medco E&P) operates offshore platform in Natuna Sea. The recent development in Natuna Sea is for marginal field. In case development of marginal field using wellhead platform concept, the challenge in built offshore platform in Natuna sea which has harsh environmental metocean and water depth range from 70 m – 100 m is limitation of crane barge for installation of offshore jacket platform. With metocean criteria and water depth in Natuna Sea, the minimum jacket weight using conventional design is about 1000 ton lifting weight, in 2019 during the Medco E&P Project executed, there is no crane barge with Indonesian flag available in market, the maximum crane barge capacity in Indonesia is 600 MT – 800 MT lift weight. Therefore, Medco E&P team should find substructure new technology for lightweight structure which could be installed by available crane in market to achieve fast track and optimized project cost for marginal field development. The new technology is required to overcome the challenges for marginal field development which requires fast track and low capital project, modular braced monopod has been selected through qualitative and quantitative assessment done amongst 6 lightweight substructure technologies during select phase. Executing project with this new technology, requiring specific project and construction strategy as well as comprehensive assessment on installation procedure and acceptance criteria. The concept of modular braced monopod has benefit in lower offshore lifting weight so require only small crane barge. The jacket consists of several parts which the maximum lifting weight for jacket component is 380 MT only. The modular braced monopod platforms for two fields in Natuna Sea has been installed and operated normally since December 2022, the project has successfully installed 1st modular braced monopod platform in Indonesia with maximum offshore lifting weight around 380 tons only for water depth 79 m compare to non-lightweight structure such as 4-legged platform for similar water depth might requires 2000 – 3000 tons crane barge capacity, the technology has supported for project cost optimization and suitable for tight schedule. The installation of modular braced monopod in the project is the fastest installation compared to other zeepod installation. Area of improvement has been documented and some recommendations for future application to be shared so that allowing better project development for other marginal project. The success story from this project will describe journey in technology selection, risk identification and mitigation, managing interfaces, high standard quality of construction and installation work, as well as providing some lesson learned to organization in executing new technology in offshore platform project.

The controlled atmospheric re-entry associated with the precision soft-landing of Reusable Launch Vehicles (RLVs) on Earth is very challenging as it depends on multiple parameters [1]. Over the last decade, the cost-effectiveness of such a technology has been finally demonstrated with the successful recoveries of SpaceX’s Falcon 9 first-stage rocket first [2], then followed by other companies such as the Rocket Lab’s Electron micro-launcher [3]. This breakthrough has been made possible by the development of advanced and robust computational methods able to generate in real time the flight conditions and to command the optimal vehicle's deflections accordingly to achieve a safe pinpoint landing. Indeed, during an Earth atmospheric re-entry, the vehicle is subjected to fast system dynamics changes partly induced by external loads associated with the terrestrial environment (e.g., lift, drag, wind and gusts), but also by the actuation commands to answer the landing constraints satisfaction and the vehicle integrity preservation. All those involve uncertainties and nonlinearities, which lead to vehicle’s instability and therefore give reason why for a highly performant Guidance, Navigation and Control system implementation [4]. More particularly, one of the critical aspects is the design of a robust control strategy capable of counteracting the previously defined disturbances and uncertainties while satisfying the strict accuracy requirements associated with the pinpoint landing [5]. As demonstrated by the current state-of-the-art on control design for launchers [6-7], the classical linear control theory represents a rich heritage with a lot of applications. This choice was motivated by its relative easiness of implementation and the possibility to use gain-scheduling techniques to adapt to nonlinear systems. Nevertheless, these techniques are well-adapted to the control system design of single-input single-output systems, such as for example a reusable rocket using a Thrust Vector Control (TVC) system as the unique actuator. The implementation of multiple-input multiple-output control systems becomes then complex since every channel is addressed in a single-loop fashion. This capability is however required for the future generation of reusable rocket, using also aerodynamic steering based on fins in addition to the TVC system for enhancing control authorities. Moreover, model uncertainties are not accurately considered in the design process, developed only with nominal conditions and stability margin requirements. For all these reasons, it results in an extensive (both in terms of time and cost) Verification and Validation campaign with many iterations and Monte-Carlo analyses to assess the performance and robustness of the control system. To overcome these drawbacks, the H-infinity family of methods, introduced a few years ago [8], provides with a powerful solution for robust control design. It relies on defining the control requirements in the frequency domain in terms of weighting functions and minimising the maximum gain of the resulting weighted system from the exogenous inputs to the outputs to be controlled. Moreover, the control-plant interaction is modelled through a Linear Fractional Transformation (LFT) representing the feedback action. Finally, the structured H-infinity method [9] allows to directly impose a specific control structure – like a Proportional-Integral-Derivative (PID), enabling the re-use of gain-scheduling techniques – and to consider parametric uncertainties for enhanced robustness. This paper studies the synthesis of a robust control system via structured H-infinity for the RLV atmospheric re-entry problem. First, the nonlinear 6-Degree-of-Freedom (6-DoF) RLV re-entry dynamics are simplified into a linear model and then linearised along a reference trajectory to get the nominal LFT of the system, then augmented with parametric uncertainties. The model covers the atmospheric re-entry and vertical landing of a first-stage rocket equipped with a TVC system and steerable planar fins. The controllers are built at different points of the re-entry trajectory, using the structured H-infinity framework through PID-like structures. Weighting functions considering the control objectives and requirements of a realistic RLV re-entry scenario are implemented. A robust stability analysis of the obtained system is performed via classical stability margins and structured singular value. Finally, the controllers are gain-scheduled and validated via Monte-Carlo analyses, using a nonlinear 6-DoF RLV re-entry dynamics simulator equipped with successive convex optimisation guidance. The performance of the resulting guidance and control architecture is compared with the baseline developed in previous works [10], using a TVC system only and classical linear feedback control through gain-scheduled PID controllers. This study lies within the ASCenSIon (Advancing Space Access Capabilities - Reusability and Multiple Satellite Injection) project, an innovative training network funded within H2020. References: [1] L. Blackmore, “Autonomous Precision Landing of Space Rockets”, The Bridge on Frontiers of Engineering, Vol. 4, No. 46, pp. 15–20 (2016). [2] M. Wall, “Wow! SpaceX Lands Orbital Rocket Successfully in Historic First”, SPACE.com (2015). Retrieval Date: 20-Jan-2022. URL: https://www.space.com/31420-spacex-rocket-landing-success.html [3] Rocket Lab (2017). “Rocket Lab Electron 'Its a Test' flight successfully makes it to space”. Retrieval Date: 20-Jan-2022. URL: https://www.rocketlabusa.com/updates/rocket-lab-successfully-makes-it-to-space-2/ [4] P. Simplício, A. Marcos, and S. Bennani. “Reusable Launchers: Development of a Coupled Flight Mechanics, Guidance, and Control Benchmark", Journal of Spacecraft and Rockets, Vol. 57, No. 1, pp. 74-89 (2020). [5] Marco Sagliano et al. “Robust Control for Reusable Rockets via Structured H-infinity Synthesis”. In: Proceedings of the 11th International ESA Conference on Guidance, Navigation & Control Systems. Virtual Event, 22-25 June 2021. [6] C. Roux and I. Cruciani, “Scheduling Schemes and Control Law Robustness in Atmospheric Flight of VEGA”. In: Proceedings of the 7th International ESA Conference on Guidance, Navigation and Control Systems. Tralee, County Kerry, Ireland 2-5 June 2008. [7] Erwin Mooij. Linear Quadratic Regulator Design for an Unpowered, Winged Re-entry Vehicle (Series 08 - Astrodynamics and Satellite Systems, No 3). Delft University Press, 1998. ISBN: 9040715971. [8] J. C. Doyle, K. Glover, P. P. Khargonekar, and B. A. Francis, “State-space Solutions to Standard H2 and H∞ Control Problems,” IEEE Transactions on Automatic Control, vol. 34, no. 8, pp. 831–847, 1989. [9] P. Apkarian and D. Noll, “Nonsmooth H∞ Synthesis,” IEEE Transactions on Automatic Control, vol. 51, no. 1, pp. 71–86, 2006. [10] Alice De Oliveira and Michèle Lavagna. “Reusable Launchers Re-entry Controlled Dynamics Simulator”. In: Proceedings of the 9th European Conference for Aeronautics and Aerospace Sciences. Lille, France, 27th June - 1st July 2022.

The Big Thicket National Preserve (BITH) vegetation inventory project classified and mapped vegetation within the administrative boundary and estimated thematic map accuracy quantitatively. National Park Service (NPS) Vegetation Mapping Inventory Program provided technical guidance. The overall process included initial planning and scoping, imagery procurement, vegetation classification field data collection, data analysis, imagery interpretation/classification, accuracy assessment (AA), and report writing and database development. Initial planning and scoping meetings took place during May, 2016 in Kountze, Texas where representatives gathered from BITH, the NPS Gulf Coast Inventory and Monitoring Network, and Colorado State University. The project acquired new 2014 orthoimagery (30-cm, 4-band (RGB and CIR)) from the Hexagon Imagery Program. Supplemental imagery for the interpretation phase included Texas Natural Resources Information System (TNRIS) 2015 50 cm leaf-off 4-band imagery from the Texas Orthoimagery Program (TOP), Farm Service Agency (FSA) 100-cm (2016) and 60 cm (2018) National Aerial Imagery Program (NAIP) imagery, and current and historical true-color Google Earth and Bing Maps imagery. In addition to aerial and satellite imagery, 2017 Neches River Basin Light Detection and Ranging (LiDAR) data was obtained from the United States Geological Survey (USGS) and TNRIS to analyze vegetation structure at BITH. The preliminary vegetation classification included 110 United States National Vegetation Classification (USNVC) associations. Existing vegetation and mapping data combined with vegetation plot data contributed to the final vegetation classification. Quantitative classification using hierarchical clustering and professional expertise was supported by vegetation data collected from 304 plots surveyed between 2016 and 2019 and 110 additional observation plots. The final vegetation classification includes 75 USNVC associations and 27 park special types including 80 forest and woodland, 7 shrubland, 12 herbaceous, and 3 sparse vegetation types. The final BITH map consists of 51 map classes. Land cover classes include five types: pasture / hay ground agricultural vegetation; non ? vegetated / barren land, borrow pit, cut bank; developed, open space; developed, low ? high intensity; and water. The 46 vegetation classes represent 102 associations or park specials. Of these, 75 represent natural vegetation associations within the USNVC, and 27 types represent unpublished park specials. Of the 46 vegetation map classes, 26 represent a single USNVC association/park special, 7 map classes contain two USNVC associations/park specials, 4 map classes contain three USNVC associations/park specials, and 9 map classes contain four or more USNVC associations/park specials. Forest and woodland types had an abundance of Pinus taeda, Liquidambar styraciflua, Ilex opaca, Ilex vomitoria, Quercus nigra, and Vitis rotundifolia. Shrubland types were dominated by Pinus taeda, Ilex vomitoria, Triadica sebifera, Liquidambar styraciflua, and/or Callicarpa americana. Herbaceous types had an abundance of Zizaniopsis miliacea, Juncus effusus, Panicum virgatum, and/or Saccharum giganteum. The final BITH vegetation map consists of 7,271 polygons totaling 45,771.8 ha (113,104.6 ac). Mean polygon size is 6.3 ha (15.6 ac). Of the total area, 43,314.4 ha (107,032.2 ac) or 94.6% represent natural or ruderal vegetation. Developed areas such as roads, parking lots, and campgrounds comprise 421.9 ha (1,042.5 ac) or 0.9% of the total. Open water accounts for approximately 2,034.9 ha (5,028.3 ac) or 4.4% of the total mapped area. Within the natural or ruderal vegetation types, forest and woodland types were the most extensive at 43,022.19 ha (106,310.1 ac) or 94.0%, followed by herbaceous vegetation types at 129.7 ha (320.5 ac) or 0.3%, sparse vegetation types at 119.2 ha (294.5 ac) or 0.3%, and shrubland types at 43.4 ha (107.2 ac) or 0.1%. A total of 784 AA samples were collected to evaluate the map?s thematic accuracy. When each AA sample was evaluated for a variety of potential errors, a number of the disagreements were overturned. It was determined that 182 plot records disagreed due to either an erroneous field call or a change in the vegetation since the imagery date, and 79 disagreed due to a true map classification error. Those records identified as incorrect due to an erroneous field call or changes in vegetation were considered correct for the purpose of the AA. As a simple plot count proportion, the reconciled overall accuracy was 89.9% (705/784). The spatially-weighted overall accuracy was 92.1% with a Kappa statistic of 89.6%. This method provides more weight to larger map classes in the park. Five map classes had accuracies below 80%. After discussing preliminary results with the parl, we retained those map classes because the community was rare, the map classes provided desired detail for management or the accuracy was reasonably close to the 80% target. When the 90% AA confidence intervals were included, an additional eight classes had thematic accruacies that extend below 80%. In addition to the vegetation polygon database and map, several products to support park resource management include the vegetation classification, field key to the associations, local association descriptions, photographic database, project geodatabase, ArcGIS .mxd files for map posters, and aerial imagery acquired for the project. The project geodatabase links the spatial vegetation data layer to vegetation classification, plot photos, project boundary extent, AA points, and PLOTS database sampling data. The geodatabase includes USNVC hierarchy tables allowing for spatial queries of data associated with a vegetation polygon or sample point. All geospatial products are projected using North American Datum 1983 (NAD83) in Universal Transverse Mercator (UTM) Zone 15 N. The final report includes methods and results, contingency tables showing AA results, field forms, species list, and a guide to imagery interpretation. These products provide useful information to assist with management of park resources and inform future management decisions. Use of standard national vegetation classification and mapping protocols facilitates effective resource stewardship by ensuring the compatibility and widespread use throughout NPS as well as other federal and state agencies. Products support a wide variety of resource assessments, park management and planning needs. Associated information provides a structure for framing and answering critical scientific questions about vegetation communities and their relationship to environmental processes across the landscape.

In this study, we examine potential temporal changes in coda Q values for two significant Canadian earthquakes in different tectonic environments: the 2017 (Mw 5.9) Barrow Strait earthquake along Canada's northern margin and the 2012 (Mw 7.8) Haida Gwaii subduction earthquake on Canada's west coast. Waveforms from 124 earthquakes (2.0 &amp;lt;/= M &amp;lt;/= 4.6) for ~30 years prior to the January 8, 2017 Barrow Strait earthquake and 66 events (mainly aftershocks of M 2.0-5.3) in about 4 years after the mainshock recorded by the closest seismic station (RES) of the Canadian National Seismograph Network (CNSN) were utilized in this study. Based on our analysis, overall average of Q0 (Q at 1 Hz) decreased from 92 (before the mainshock) to 81. The most significant decrease in the frequency range between 2 and 16 Hz is observed for areas corresponding to ellipse parameter a2 of 50, 70 and 80 mainly related to aftershock activity. Precursory Q changes could not be evaluated before the mainshock due to the lack of reported seismicity within 100 km of the recording seismic station for almost 2 years from April 2015 to January 2017. Coda Q values before and after the October 28, 2012 Haida Gwaii earthquake in British Columbia show a similar pattern. Waveforms from 249 earthquakes (2.0 &amp;lt;/= M &amp;lt;/= 4.9) in 2 years before the mainshock and 498 events (2.5 &amp;lt;/= M &amp;lt;/= 6.3) in 2 years after the mainshock recorded by the three closest seismic stations of the CNSN were utilized. Overall average of Q0 decreased from 89 (before the mainshock) to 69 (station BNB), from 90 to 79 (station DIB) and from 86 to 78 (station VIB). In general, these results are in agreement with other global studies that show a decrease in Q0 following a major earthquake, likely the result of increased fracturing and fluids in the epicentral region.

A testing program was conducted to evaluate the effects of internal pressure during the installation of composite and steel sleeves repair systems on pipelines with plain dents. The testing program included cyclic pressure testing a group of 12.75-inch OD x 0.188-inch WT, Grade X42 pipe samples with plain dents having residual dent depths on the order of 3% to 4% of the pipe's outside diameter. The dent samples were repaired using four (4) different composite repair systems, type-A steel sleeves, and steel thermal compression sleeves. The composite repair systems included a carbon fiber wet-layup, an E-glass wet-layup, a system with precured plies, and a hybrid composite-steel repair system. To determine the effect internal pressure has on repair installation for dents, all repairs were installed with an internal pressure of 64% SMYS (793 psig) in the pipe sample. The dent samples were then pressure cycled between 8 - 80% SMSY ( and Delta;P = 900 psig) until failure or reaching the runout condition of 250,000 cycles. Only three (3) out of the fourteen (14) repaired dents reached the 250,000 pressure cycle runout condition and these samples were all repaired using steel sleeves. The maximum number of cycles reached by any composite repair was approximately 200,000 cycles while the least number of cycles reached was approximately 24,000 cycles. In addition to the dent repairs, two (2) 12.75-inch OD x 0.375-inch WT, Grade X42 pipe samples with a 6-inch x 8-inch corrosion defect were repaired with an E-glass wet-layup. These two (2) samples were a continuation of a previous study that investigated the effects of a 50% SMYS (1,235 psig) installation pressure on the fatigue performance of corrosion repairs. Both samples reached the runout condition of 250,000 cycles. The body of work is seminal in that it is the first time that industry was evaluated a wide range of repair technologies to determine the effects of pressure during installation in reinforcing plain dents. It has been speculated for some time that internal pressure present during installation of composite repair technologies has an impact on fatigue performance. Although corrosion features do not appear to be a concern, the reinforcement of dents with internal pressure requires careful consideration. Because gas transmission pipelines do not experience aggressive pressure cycling, the effects of pressure present during installation are not a major concern. However, liquid transmission pipeline operators should be cognizant of the pressure effects and respond accordingly. Namely, pressure should be reduced during installation as much as possible.

Si l’on s’en tient aux chiffres de la vaccination contre la COVID-19 dans les pays du G7, la campagne apparaît comme un véritable succès tant au niveau global qu’au niveau national. En effet, à ce jour, 79,4 % de la population totale des pays du G7 a reçu une première dose, 72,9 % une seconde, et 45,4 % une dose de rappel (données du 28 avril 2022) 1 En France, c’est 80,6 % de la population totale qui a reçu une première dose, 78,2 % qui a reçu deux doses, et 55,4 % qui a reçu un rappel (données du 28 avril 2022).2 Au Royaume-Uni, 79,3 % de la population totale a reçu une première dose, 74,1 % une seconde, et 58,5 % un rappel.1 Enfin, en Italie, 85,2 % de la population totale a reçu une première dose, 80,4 % a reçu deux doses et 66,5 % a reçu leurs rappels (données du 28 avril 2022). Ces taux de vaccination élevés masquent pourtant des disparités importantes à l’intérieur de chaque pays. Ainsi, à Marseille, deuxième ville de France, moins de 50 % des habitants des quartiers nord de la ville étaient vaccinés à la fin de l’année 2021, alors que plus de 70 % des habitants des quartiers sud l’étaient au même moment.3 Dans le quartier populaire de Ealing, situé au nord-ouest de Londres, 70 % de la population admissible avait reçu une première dose, soit près de 10 % de moins que la moyenne nationale. 4 (Données du 4 avril 2022). Des disparités similaires ont été observées dans d’autres métropoles urbaines des pays du G7. Ce document examine ces disparités au prisme de la notion d’« (in)égalité vaccinale ». En s’appuyant sur des recherches qualitatives menées pendant la campagne de vaccination de la COVID-19 dans les quartiers nord de Marseille, le quartier de Ealing à Londres (Nord-ouest) et dans la région de l'Émilie-Romagne et à Rome, en Italie, il montre comment les autorités locales peuvent agir pour atténuer ces inégalités. Mieux comprendre les inégalités en matière de vaccins fut primordial lors de la pandémie de la COVID-19 en ce sens que les populations sous-vaccinées étaient la plupart du temps des minorités ethniques ou culturelles, vivant dans des zones défavorisées, ou sans-papiers, donc plus susceptibles de contracter la COVID-19, et d’en subir les conséquences les plus dramatiques. 5 6 7 8 Ainsi, à Ealing, quatre mois après la campagne de vaccination, seulement 57,6% des personnes dans le décile de pauvreté le plus bas avaient reçu une dose, contre 81% des personnes dans le décile le plus aisé. 9 En outre, 89,2 % des résidents britanniques blancs de Ealing étaient vaccinés, contre 64 % des Pakistanais et 49,3 % des habitants issus des Caraïbes.9 À Rome, comme c’est le cas dans d’autres métropoles urbaines des pays du G7, nos données révèlent des disparités particulières importantes entre le recours aux vaccins des populations sans papiers et celui des citoyens établis. Les facteurs d’inégalité vaccinale dans ces environnements urbains sont complexes et liés à l’interaction de nombreux phénomènes tels que les inégalités économiques, le racisme structurel, l'inégalité d'accès aux soins de santé, la méfiance envers les professionnels de santé, les représentants de l'État, et plus encore. Les collectivités locales tout comme les professionnels de la santé, les groupes communautaires et les résidents jouent un rôle clé dans la manière dont s’exprime l’(in)égalité vaccinale. Pour autant, peu de leçons ont été systématiquement tirées des efforts menés en matière d’ «engagement vaccinal » au niveau local. Dans ce document, nous proposons d’expliquer comment l’expérience des inégalités structurelles se recoupe avec celle des habitants, et comment ces expériences ont été prises en compte ou au contraire ignorées dans la promotion et l’administration des vaccins contre la COVID-19 par les collectivités locales. Nous adressons également un ensemble de recommandations qui s’appliquent aux programmes de « vaccination de rattrapage » contre la COVID-19 (visant à atteindre les personnes qui n’ont pas encore reçu leur schéma vaccinal complet), mais elles concernent également les programmes de vaccination d'urgence à venir. Ce document repose sur des recherches menées entre octobre et décembre 2021 à Marseille et sur des échanges réguliers avec les autorités du Borough de Ealing initiés dès mai 2021. Il identifie comment les gouvernements locaux, les acteurs de la santé, les groupes communautaires et les résidents jouent un rôle clé dans la production d’(in)égalités vaccinales. Ce document a été élaboré pour la SSHAP par Santiago Ripoll (IDS), Tavitha Hrynick (IDS), Ashley Ouvrier (LaSSA), Megan Schmidt-Sane (IDS), Federico Federici (UCL) et Elizabeth Storer (LSE). Il a été revu par Eloisa Franchi (Université de Pavie) et Ellen Schwartz (Conseil de santé publique de Hackney). La recherche a été financée par la British Academy COVID-19 Recovery : Fonds G7 (COVG7210038). Les recherches ont été menées à l’Institut d’études du développement (IDS), à l’Université de Sussex et au Laboratoire des sciences sociales appliquées (LaSSA). La SSHAP en assume la responsabilité.