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Статті в журналах з теми "697,1, 697.27"
1
Agliano, Alice, Ines Martin-Padura, Paola Merighetti, Patrizia Mancuso, Cristina Rabascio, Leonard D. Shultz, and Francesco Bertolini. "Comparison of Three Different NOD/SCID-Related Strains in Preclinical Models of Acute Leukemia." Blood 108, no. 11 (November 1, 2006): 2361. http://dx.doi.org/10.1182/blood.v108.11.2361.2361.
Повний текст джерелаАнотація:
Abstract Transplantation of human acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) primary cells and cell lines in a variety of different strains of immunodeficient mice has led to preclinical models extensively used to investigate AML and ALL stem cells, biology, and drug sensitivity. We investigated the engraftment kinetics of two AML cell lines (HL-60 and KG-1), two ALL cell lines (MOLT-16 and 697) and AML primary cells from an AML M4 patient (QD1-EIO, described in Fusetti et al, Cancer Res 2000) in 3 different strains of NOD/LtSz-Prkdcscid (NOD/SCID, NS)-related immunodeficient mice. NS, NS/beta2 null (NSB) and NOD/SCID/IL-2Rgamma null (NSG) mice were injected ip with 10x106 AML or ALL cells. Mice were observed daily and sacrificed when leukemia-related symptoms were evident. Overall, leukemia-related symptoms were observed in 71, 84 and 86% of NS, NSB and NSG mice, respectively (n=42, p<0.01), after a median of 53, 49 and 35 days (p<0.001). Leukemia engraftment was investigated in the marrow, the blood and the spleen by means of morphology, flow cytometry and quantitative PCR for human genes. AML HL-60 and KG-1 cells accounted for 10-6, 5-1 and 7-3 % of peripheral blood cells in NS, NSB and NSG mice, respectively. ALL MOLT-16 and 697 cells accounted for 2-12, 22-27 and 1-27 % of blood cells in NS, NSB and NSG mice, respectively. AML primary cells QD1-EIO accounted for <1, <1 and 3% of blood cells in NS, NSB and NSG mice, respectively. Similar engraftment results were observed in the marrow and in the spleen. Leukemia cell-injected NSG mice, compared to NS and NSB, showed a significantly higher increase of circulating endothelial mature cells (CEC, enumerated by flow cytometry as CD45−, CD13+ VEGFR2+ cells) and progenitors (CEP, enumerated by flow cytometry as CD45−, CD13+ VEGFR2+ CD117+ cells, see Shaked et al, Cancer Cell 2005). This CEC and CEP increase paralleled leukemia engraftment. Taken together, our data indicate that the 3 different strains have significantly different leukemia engraftment behavior and kinetics. Engraftment in NSG mice is significantly faster compared to the other two strains, leukemia-related microenvironment is differently modulated, and less leukemic burden might be needed to observe leukemia-related symptoms. These data might have major implications to design future studies on leukemia-initiating stem cells, leukemia biology and preclinical leukemia treatment studies.
2
Bugdayli, K., P. Ungprasert, K. J. Warrington, and M. Koster. "POS0800 VISUAL ISCHEMIA DURING RELAPSE AND FOLLOW-UP OF GIANT CELL ARTERITIS: A SYSTEMATIC REVIEW." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 652.2–652. http://dx.doi.org/10.1136/annrheumdis-2021-eular.697.
Повний текст джерелаАнотація:
Background:Visual ischemia (VI) is one of the most feared complications in giant cell arteritis (GCA). While the frequencies of VI development at or near diagnosis are better studied, limited information is available regarding the frequency of VI during relapse.Objectives:The purpose of this study was to characterize the frequency of visual ischemia (VI) as a manifestation of relapse or during follow-up in patients with GCA through performance of a systematic literature review.Methods:Potentially eligible studies were identified from Medline and EMBASE databases from inception to November 31, 2019 using a search strategy that comprised of terms for “giant cell arteritis,” “temporal arteritis,” or “Horton’s disease,” with “relapse,” “recurrence,” “flare,” “outcome,” “follow-up,” or “prognosis.” VI was defined as transient or permanent, full or partial, monocular or binocular visual field loss. VI occurring within 4 wks of GCA diagnosis was considered due to active disease and not included as a relapse event. Inclusion criteria used: (1) original research reported in English, (2) GCA definition provided, (3) VI outcome described as one of the following: (a) relapse rate/frequency denoting the presence or absence of VI, or (b) absolute number of VI events (> 4 weeks after GCA diagnosis) even if total cohort relapse rate/frequency was not provided. In order to reduce bias from under-reporting of negative results, studies that reported relapse rates/frequencies with accompanying relapse characteristics but did not provide initial detail regarding the presence/absence of VI were also identified. In such circumstances, the primary authors were directly contacted for patient-level data regarding VI and these studies were included in the final analysis if such data were available and provided.Results:A total of 913 unique articles were identified and underwent screening. Among these, 148 articles underwent independent full-text review by two physicians (K.B. and M.J.K). 33 articles met full inclusion criteria and an additional 21 articles included data on relapse but did not report VI patient data in the publication. Responses were received from authors of 11 of these 21 studies allowing for inclusion. 44 studies accounting for 3,649 patients with GCA were identified. Average percentage of baseline VI was 19% (range 0-66%). The average length of follow-up was 3.4 years (range 0.4 to 8.7). VI developing > 4 weeks after GCA diagnosis was recorded in a total of 53 patients (1.5%).Study-defined relapses were reported in 36 studies. A total of 1,215 patients with at least one or more relapses were recorded among 2,592 patients under observation (47%). Among these 36 studies, VI occurred in 37 patients (3.0%) with at least one study defined relapse event.Comparing trial design, retrospective studies (n=25) reported 27 of 2,718 (1%) patients developed VI during follow-up whereas 19 of 541 (3.5%) patients in randomized controlled trials (n=8) developed VI during the trial or post-trial follow-up.Conclusion:This report outlines the first systematic review evaluating VI as a manifestation of relapse and during follow-up in GCA. Overall, VI > 4 weeks after GCA diagnosis is uncommon (1.5%) but is noted in up to 3% of patients with at least one relapse event. Frequencies of reported VI were 3.5 times higher in randomized controlled trials compared to retrospective studies.Disclosure of Interests:Kubra Bugdayli: None declared, Patompong Ungprasert: None declared, Kenneth J Warrington Grant/research support from: Financial support for research from Kiniksa, Eli Lilly, Matthew Koster: None declared
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Gu, Yan, Chunhua Song, Sinisa Dovat, Qinglong Guo, Qinyu Ge, and Zheng Ge. "Oncogenesis of CRLF2 Overexpression and Effect of JAK2 Inhibitor in CRLF2 Overexpressed B-Cell Acute Lymphoblastic Leukemia." Blood 134, Supplement_1 (November 13, 2019): 2757. http://dx.doi.org/10.1182/blood-2019-125259.
Повний текст джерелаАнотація:
Backgroud: Cytokine receptor-like factor 2 (CRLF2) plays an important role in the development of normal B lymphocytes, which can mediate the proliferation of early B cells. However, the diect oncogenic effect of CRLF2 overexpression in acute lymhpoblastic leukemia (ALL) is far yet to be clarified. Here, we explored the effect of CRLF2 overexpression on cell proliferation and the effect of the novel JAK2 inhibitor on B-ALL cells with CRLF2 overexpression. Methods: The 83 patients with newly-diagnosed ALL (56 B-cell and 27 T-cell ALL; range from 14 to 77 years old) between June 2008 and June 2016 were studied at Zhongda Hospital Southeast University. The 21 normal bone marrow subjects were enrolled as controls. The qPCR method is developed for detection CRLF2 expression and the CRLF2 overexpression was determined with a cutoff value more than the highest sample of normal bone marrow control. Median differences between the cohorts were evaluated using a Mann-Whitney U-test. Frequency differences were analyzed using uni- and multivariate Cox model. Event-free survival (EFS) and overall survival (OS) were estimated by the Kaplan-Meier method and compared by log-rank test. CRLF2 F232C gain-of-function mutant which we previously reported or CRLF2 were expressed in Nalm6 and 697 B-ALL cells with lentiviral transduction. WST-1 cell proliferation assay and in vitro clonogenic assay were performed upon JAK2 inhibitor (BBT594) treatment. Nalm6-CRLF2-luc, Nalm6-F232C-luc, and Nalm6-vector-luc cells were injected via tail vein into the NSG mice. The leukemia engraftment was monitored once a week by living imaging. Results: The expression of CRLF2 in patietns with ALL was significantly higher than the normal control (P<0.0001). Patients with CRLF2 overexpression had a significantly higher WBC count (53*10^9/L vs. 29.5*10^9/L, P=0.041). Survival analysis showed that the patients with CRLF2 overexpression had a worse EFS and OS, the differences were statistically significant (11 months vs. 26 months, P=0.043 and 15 months vs. 32 months, P=0.015). Also, the CRLF2 expression is determined with flow cytometry after staining with FITC-CRLF2 antibody in 28 samples. The correlation analysis was performed on the CRLF2 expression detected by qPCR and flow cytometry, respectively. A significant positive correlation of the two methods was observed(r=0.957, P<0.0001). These data not only indicate that CRLF2 overexpression is a marker of poor outcome, but also reveal the qPCR might be a simple and quick method for screening CRLF2 overexpression in the clinic compared to flow cytometry which is commonly used. We further found that expression of CRLF2 or CRLF2 F232C mutant into Nalm6 and 697 B-ALL cells dramatically increase the CRLF2 mRNA level, which is 69 times than vector-only control. Moreover, CRLF2 or CRLF2 F232C significantly promotes the cell proliferation of Nalm6 and 697 cells compared to vector only (P<0.001). In addition, JAK2 inhibitor (BBT594) treatment showed the significant dose-dependent cell proliferation arrest and clonogenic inhibition in CRLF2 or CRLF2 F232C overexpressed Nalm6 and 697 cells compared to vector-only control. Furthermore, in vivo we observed the 5-fold higher signal intensity of leukemia engraftment in the mice injected with Nalm6-CRLF2-luc or Nalm6-F232C-luc compared to that of Nalm6-vector-luc control 1-3 weeks after the injection(P<0.001). The Nalm6-CRLF2-luc and Nalm6-F232C-luc infiltrations were observed in bone marrow, central nervous system, liver and spleen of the mice. Conclusion: We showed that CRLF2 overexpression could enhance the proliferation and infiltration of human B-ALL cells, and for the first time indicated that JAK2 inhibitor could suppress the cell proliferation and clonogenesis of the CRLF2 overexpressed B-ALL cells. Our data provide direct evidence of the oncogenic role of CRLF2 overexpression and the new therapeutic potential for targeting CRLF2 overexpressed B-ALL with JAK2 inhibitor. Disclosures No relevant conflicts of interest to declare.
4
Biggs, JC, J. Szer, P. Crilley, K. Atkinson, K. Downs, A. Dodds, AJ Concannon, B. Avalos, P. Tutschka, and N. Kapoor. "Treatment of chronic myeloid leukemia with allogeneic bone marrow transplantation after preparation with BuCy2." Blood 80, no. 5 (September 1, 1992): 1352–57. http://dx.doi.org/10.1182/blood.v80.5.1352.1352.
Повний текст джерелаАнотація:
Abstract One hundred fifteen patients with chronic myelocytic leukemia (CML) were administered busulphan 4 mg/kg for 4 days and cyclophosphamide 60 mg/kg on each of 2 days (BuCy2) followed by allogeneic bone marrow transplantation from histocompatible sibling donors. For 62 patients in chronic phase, 26 in accelerated phase, and 27 in blast transformation, the actuarial survival at 3 years was 58%, 41%, and 25%, respectively. Actuarial probability of relapse was 3%, 12%, and 27%, respectively. Only two patients in chronic phase showed a transient cytogenetic relapse and one of these died from subsequent transplant-related complications, whereas the other remains cytogenetically normal 697 days posttransplant. Patients who were transplanted within 1 year of diagnosis in chronic phase had a survival of 70% compared with 40% when transplanted beyond 1 year from diagnosis. This significant difference in survival was due to transplant-related complications and was correlated with previous exposure to high doses of busulphan. This study indicates that BuCy2 is a useful conditioning regimen for marrow transplantation in patients with CML and results in similar survival statistics and transplant-related mortality as would be expected with conditioning regimens containing total body irradiation. It is possible that relapse after BuCy2 may be lower than expected with regimens containing total body irradiation, but larger analyses are required.
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Biggs, JC, J. Szer, P. Crilley, K. Atkinson, K. Downs, A. Dodds, AJ Concannon, B. Avalos, P. Tutschka, and N. Kapoor. "Treatment of chronic myeloid leukemia with allogeneic bone marrow transplantation after preparation with BuCy2." Blood 80, no. 5 (September 1, 1992): 1352–57. http://dx.doi.org/10.1182/blood.v80.5.1352.bloodjournal8051352.
Повний текст джерелаАнотація:
One hundred fifteen patients with chronic myelocytic leukemia (CML) were administered busulphan 4 mg/kg for 4 days and cyclophosphamide 60 mg/kg on each of 2 days (BuCy2) followed by allogeneic bone marrow transplantation from histocompatible sibling donors. For 62 patients in chronic phase, 26 in accelerated phase, and 27 in blast transformation, the actuarial survival at 3 years was 58%, 41%, and 25%, respectively. Actuarial probability of relapse was 3%, 12%, and 27%, respectively. Only two patients in chronic phase showed a transient cytogenetic relapse and one of these died from subsequent transplant-related complications, whereas the other remains cytogenetically normal 697 days posttransplant. Patients who were transplanted within 1 year of diagnosis in chronic phase had a survival of 70% compared with 40% when transplanted beyond 1 year from diagnosis. This significant difference in survival was due to transplant-related complications and was correlated with previous exposure to high doses of busulphan. This study indicates that BuCy2 is a useful conditioning regimen for marrow transplantation in patients with CML and results in similar survival statistics and transplant-related mortality as would be expected with conditioning regimens containing total body irradiation. It is possible that relapse after BuCy2 may be lower than expected with regimens containing total body irradiation, but larger analyses are required.
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LOOH, George Ashwehmbom, Fondzenyuy Cedric MANGEH (III), Xunwei WANG, and Xiushan WANG. "Performance Assessment of a Self-propelled Paddy Grain Thresher under Different Threshing Functional Parameters." Applied Engineering in Agriculture 36, no. 2 (2020): 141–49. http://dx.doi.org/10.13031/aea.13585.
Повний текст джерелаАнотація:
HighlightsThis research was aimed at assessing the performance of a self-propelled paddy grain thresher.Increasing cylinder speed increased the threshing percentage and percentage of broken grains of the machine.More broken grains were obtained at a lower concave clearance.The feed rate did not have much significance on the performance parameters that were evaluated. Abstract.This research was conducted to assess the performance of a self-propelled mini combine harvester, model number 4LZ-0.8 under different threshing functional parameters such as cylinder speed, concave clearance, and feed rate. An indoor experiment was conducted using the mini combine with an axial flow threshing cylinder and tangential feeding of material. These functional parameters were set at 5 levels each. The responses were obtained in terms of threshing percentage, percentage of unthreshed grains and percentage of broken grains. Response values were analyzed using the response surface tool (rstool) in MATLAB. Analysis of variance was done to determine the significant effects of the factor variations on the response values. MATLAB was used to present response surface graphs that were used to describe the variations of the responses as the factors changed from one level to the other. Results showed that with an increase in cylinder speed from 697 to 1202 rpm, the percentage of broken grains increased significantly from 0.0384% to 3.4052%, respectively. At cylinder speeds of 697 and 1202 rpm, the percentage of unthreshed grains increased from 0.1515% to 0.2162%, respectively. Furthermore, an increase in feed rate decreased the threshing percentage. The highest threshing percentage was obtained at an average concave clearance of 27 mm. Furthermore, it was realized that increasing the concave clearance from 18 to 35 mm, equally increased the percentage of unthreshed grains from 0.1478% to 0.3177%. The percentage of grain damage decreased from 3.2758% to 0.0268% with an increase in concave clearance from 18 to 35 mm, respectively. From the results obtained, it was tested and suggested that operating the threshing cylinder at a cylinder speed of 1100 rpm, concave clearance of 27 mm and feed rate of 0.9 kg s-1 offered the best machine performance. At these suggested values of the operating parameters, the threshing percentage was 99.9801%, the percentage of broken grains was 0.0134%, and the percentage of unthreshed grains was 0.0199%. Keywords: Assessment, Axial threshing unit, Cylinder speed, Concave clearance, Feed rate, Functional parameters, Threshing percentage.
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Pacora Portella, Percy. "Macrosomía fetal: Definición, Predicción, Riesgos y Prevención." Revista Peruana de Ginecología y Obstetricia 39, no. 17 (July 28, 2015): 42–50. http://dx.doi.org/10.31403/rpgo.v39i1633.
Повний текст джерелаАнотація:
Tradicionalmente la macrosomía fetal ha sido definida en base a un peso arbitrario. Sin embargo, la macrosomía fetal actualmente debe ser definida como el feto grande para la edad de gestación ( > percentil 90) en base al incrementado riesgo perinatal que presenta. En un estudio prospectivo que incluyó 1 697 gestaciones simples, 278 tuvieron fetos macrosómicos (GEG) y 1 336 fueron fetos de tamaño adecuado (AEG). Los factores predictivos de GEG en orden de especificidad fueron: ganancia ponderal excesiva (70%), feto de sexo varón (77%), grosor placentario > 4 cm (74%), edad mayor de 30 años (41,7%), obesidad (33,5%), antecedente de feto grande (27%), glicemia en ayunas > 79 mg/dl (21,6%), glucosa posprandial a las 2 horas > 110 mg/dl (20,7%), talla > 160 cm (20%), diabetes familiar (113,7%) y anemia (10,1 %). Las complicaciones maternas que debieran hacernos pensar en macrosomía fetal son ganancia ponderal excesiva, anemia, amenaza de aborto, placenta previa, polihidramnios, circular de cordón, hipertensión arterial asociada con ruptura prematura de membranas, labor disfuncional con enfoque de riesgo y el empleo de medidas de restricción calórica, insulina profiláctica y la inducción del parto antes de la semana 42, a fin de prevenir la macrosomía fetal.
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Asfandiyarova, Nailya S. "Risk factors of death in diabetes mellitus." Clinical Medicine (Russian Journal) 94, no. 9 (November 2, 2016): 697–700. http://dx.doi.org/10.18821/0023-2149-2016-94-9-697-700.
Повний текст джерелаАнотація:
Objective. To study risk factors of death in diabetes mellitus (DM). Materials and methods. This prospective cohort study included 337 patients with compromised carbohydrate metabolism (36 with impaired fasting glycemia or impaired glucose tolerance, 80 with type 1 diabetes, 194 with type 2 diabetes, 27 with diabetes due to chronic pancreatitis). Mean follow-up was 11.2±4.8 years (from 1 January 1995 through 31 December 2014). We investigated causes and risk factors of death in patients with impaired carbohydrate metabolism. Results. 115 patients died during the study period. The most common causes of death of patients with type 1 and 2 diabetes are cardiovascular diseases and cancer. Risk factors of death in type 1 DM include cardiovascular disease, diabetic nephropathy and retinopathy. Patients die at a younger age due to early onset of the disease. In type 2 diabetes risk factors of death are cardiovascular and oncologic diseases, nephropathy, the use of insulin. Patients die in elderly and senile age due to the late onset of diabetes. Gender differences in mortality associated with type 1 and 2 diabetes mellitus were not observed. Conclusion. Main causes of death in patients with type 1 and 2 DM are cardiovascular diseases and cancer. Risk factors of death include macro - and microvascular complications.
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Bentley, Robert F., Jeremy J. Walsh, Patrick J. Drouin, Aleksandra Velickovic, Sarah J. Kitner, Alyssa M. Fenuta, and Michael E. Tschakovsky. "Dietary nitrate restores compensatory vasodilation and exercise capacity in response to a compromise in oxygen delivery in the noncompensator phenotype." Journal of Applied Physiology 123, no. 3 (September 1, 2017): 594–605. http://dx.doi.org/10.1152/japplphysiol.00953.2016.
Повний текст джерелаАнотація:
Recently, dietary nitrate supplementation has been shown to improve exercise capacity in healthy individuals through a potential nitrate-nitrite-nitric oxide pathway. Nitric oxide has been shown to play an important role in compensatory vasodilation during exercise under hypoperfusion. Previously, we established that certain individuals lack a vasodilation response when perfusion pressure reductions compromise exercising muscle blood flow. Whether this lack of compensatory vasodilation in healthy, young individuals can be restored with dietary nitrate supplementation is unknown. Six healthy (21 ± 2 yr), recreationally active men completed a rhythmic forearm exercise. During steady-state exercise, the exercising arm was rapidly transitioned from an uncompromised (below heart) to a compromised (above heart) position, resulting in a reduction in local pressure of −31 ± 1 mmHg. Exercise was completed following 5 days of nitrate-rich (70 ml, 0.4 g nitrate) and nitrate-depleted (70 ml, ~0 g nitrate) beetroot juice consumption. Forearm blood flow (in milliliters per minute; brachial artery Doppler and echo ultrasound), mean arterial blood pressure (in millimeters of mercury; finger photoplethysmography), exercising forearm venous effluent (ante-cubital vein catheter), and plasma nitrite concentrations (chemiluminescence) revealed two distinct vasodilatory responses: nitrate supplementation increased (plasma nitrite) compared with placebo (245 ± 60 vs. 39 ± 9 nmol/l; P < 0.001), and compensatory vasodilation was present following nitrate supplementation (568 ± 117 vs. 714 ± 139 ml ⋅ min−1 ⋅ 100 mmHg−1; P = 0.005) but not in placebo (687 ± 166 vs. 697 ± 171 min−1 ⋅ 100 mmHg−1; P = 0.42). As such, peak exercise capacity was reduced to a lesser degree (−4 ± 39 vs. −39 ± 27 N; P = 0.01). In conclusion, dietary nitrate supplementation during a perfusion pressure challenge is an effective means of restoring exercise capacity and enabling compensatory vasodilation. NEW & NOTEWORTHY Previously, we identified young, healthy persons who suffer compromised exercise tolerance when exercising muscle perfusion pressure is reduced as a result of a lack of compensatory vasodilation. The ability of nitrate supplementation to restore compensatory vasodilation in such noncompensators is unknown. We demonstrated that beetroot juice supplementation led to compensatory vasodilation and restored perfusion and exercise capacity. Elevated plasma nitrite is an effective intervention for correcting the absence of compensatory vasodilation in the noncompensator phenotype.
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Sri, Trisha, Eleanor Southgate, Sarah R. Kerry, Claire Nightingale, and Pippa Oakeshott. "Health-related quality of life and Chlamydia trachomatis infection in sexually experienced female inner-city students: a community-based cross-sectional study." International Journal of STD & AIDS 28, no. 4 (July 10, 2016): 367–71. http://dx.doi.org/10.1177/0956462416650095.
Повний текст джерелаАнотація:
This cross-sectional study was undertaken to compare health-related quality of life (EQ-5D) in women with and without undiagnosed Chlamydia trachomatis infection. We analysed data from 2401 multi-ethnic sexually active female students aged 16–27 years who were recruited to a randomised controlled trial of chlamydia screening – the prevention of pelvic infection trial in 2004–2006. At recruitment, all participants were asked to provide self-taken vaginal swabs for chlamydia testing and to complete a sexual health questionnaire including quality of life (EQ-5D). Most women (69%) had an EQ-5D of one representing ‘perfect health’ in the five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. We therefore compared the proportion of women with an EQ-5D score < 1 implying ‘less than perfect health’ in women with and without chlamydia infection, and women with symptomatic chlamydia versus the remainder. The proportion of women with EQ-5D score < 1 was similar in women with and without undiagnosed chlamydia: 34% (47/138) versus 31% (697/2263; RR 1.11, 95% CI 0.87 to 1.41). However, more women with symptomatic chlamydia had EQ-5D score < 1 than the remainder: 45% (25/55) versus 31% (714/2319; RR 1.47, CI 1.10 to 1.98). In this community-based study, EQ-5D scores were similar in women with and without undiagnosed chlamydia. However, a higher proportion of women with symptomatic chlamydia infection had ‘less than perfect health’. Undiagnosed chlamydia infection may not have a major short-term effect on health-related quality of life, but EQ-5D may not be the best tool to measure it in this group.
Дисертації з теми "697,1, 697.27"
1
Hodoul, Patrick. "Étude de qualités architecturales dans un contexte industriel." Mémoire, École de technologie supérieure, 2004. http://espace.etsmtl.ca/697/1/HODOUL_Patrick.pdf.
Повний текст джерелаАнотація:
La conception d'une nouvelle architecture logicielle est toujours une étape importante et risquée de la conception d'un nouveau produit logiciel. Ainsi, l'entreprise ABC souhaite pouvoir réduire ce risque. La proposition faite à l'ÉTS consiste donc à utiliser cette problématique pour concevoir des outils pour simplifier et faciliter la conception d'une nouvelle architecture logicielle en se basant sur les attributs de qualité.
Notre recherche bibliographique nous a permis de trouver des méthodes qui couvrent cette problématique. Ces méthodes améliorent les processus tels que le processus unifié de Rational (RUP), pour mieux considérer les attributs de qualité lors de l'analyse de l'architecture logicielle, mais semblent porter peu d'attention à la qualité des artéfacts. Ainsi, nous avons amélioré certains concepts existants et proposé de nouveaux concepts dans le but d'améliorer cette qualité. De plus, nous avons introduit une étape intermédiaire basée sur des spécifications architecturales pour essayer de simplifier ces méthodes.
Notre proposition est une méthode systématique, complémentaire aux méthodes existantes, de définition des attributs de qualité dans le contexte de l'analyse d'architecture logicielle qui devrait répondre à notre problématique.
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Barbosa, Filho Joamir. "Miniestaquia, enxertia e alporquia de Khaya anthotheca." Universidade Federal de Mato Grosso, 2015. http://ri.ufmt.br/handle/1/697.
Повний текст джерелаАнотація:
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A Khaya anthotheca A. Juss. (Welw.) é uma espécie de mogno africano que desponta no cenário brasileiro como alternativa promissora para o florestamento visando a produção de madeira nobre. Contudo, o elevado custo de suas sementes aliado ao curto período de viabilidade são alguns fatores que dificultam a oferta de mudas no mercado a preços acessíveis. O objetivo da presente pesquisa foi avaliar a eficiência das técnicas de miniestaquia, enxertia e alporquia visando estabelecer protocolos de propagação clonal de genótipos de Khaya anthotheca. Na primeira etapa do experimento de miniestaquia, as minicepas foram submetidas às seguintes soluções de fertirrigação: S100 - 100% da concentração dos sais da solução nutritiva básica (testemunha), S50 - 50% da concentração dos sais da solução nutritiva básica e S25 - 25% da concentração dos sais da solução nutritiva básica. O delineamento experimental foi em blocos completos ao acaso em arranjo fatorial (3x5) com parcelas subdivididas no tempo, sendo os fatores constituídos por 3 soluções de fertirrigação (S100, S50 e S25) e 5 coletas de propágulos, sendo avaliadas a sobrevivência e a produção de miniestacas. Na segunda etapa do experimento de miniestaquia, foram confeccionadas miniestacas a partir dos propágulos obtidos de minicepas, as quais foram submetidas a diferentes soluções nutritivas (S100, S50 e S25). Parte das miniestacas foram tratadas com ácido indolbutírico (AIB), na concentração de 2 g.L-1 e a outra parte não foi tratada com AIB (testemunha). O experimento foi conduzido no delineamento inteiramente casualizado no arranjo fatorial (3x5x2) com parcelas subdivididas no tempo, sendo os fatores constituídos por 3 soluções de fertirrigação (S100, S50 e S25), 5 coletas de propágulos e duas concentrações de AIB (A0 - ausência de AIB, testemunha e A2 - 2 g.L-1 de AIB), sendo avaliada a sobrevivência de miniestacas na saída da casa de vegetação (SCV); sobrevência na saída da casa de sombra (SCS); enraizamento em pleno sol (EAPS) e presença de calo (CAL). Em um terceiro experimento referente às combinações entre enxertos de Khaya anthotheca e Swietenia macrophylla King., foram testadas combinações de porta-enxerto + enxerto, as quais foram: TSK - Swietenia macrophylla + Khaya anthotheca; TKS - Khaya anthotheca + Swietenia macrophylla; TSS - Swietenia macrophylla + Swietenia macrophylla; TKK - Khaya anthotheca + Khaya anthotheca. O experimento foi conduzido no delineamento em blocos ao acaso, sendo os tratamentos constituídos pela combinação dos materiais enxertados onde foi avaliado o pegamento aos 45 e aos 200 dias após a realização do enxerto, seguido da análise histológica. No quarto experimento foi realizada a alporquia nas mudas de Khaya anthotheca que estavam sendo fertirrigadas com as soluções S100, S50 e S25 e, após 45 dias, foi realizada a alporquia com três concentrações de AIB (A0 - ausência de AIB, testemunha; A3 - 3 g.L-1 de AIB e A8 - 8 g.L-1 de AIB). O experimento foi conduzido no delineamento em blocos completos ao acaso, em arranjo fatorial (3x3), sendo os fatores constituídos por 3 soluções de fertirrigação e 3 concentrações de AIB. A xii sobrevivência de minicepas não variou significativamente ao longo das coletas de brotações e não dependeu da solução nutritiva. A produção de miniestacas por metro quadrado ao ano dependeu da solução nutritiva, onde a S100 (100% da concentração de macro e micronutrientes) resultou nos maiores valores para a maioria das coletas de brotações. Houve elevada sobrevivência de miniestacas na saída da casa de vegetação, independente das coletas de propágulos, solução nutritiva e aplicação de AIB. A porcentagem de sobrevivência de miniestacas na saída da casa de sombra e o enraizamento em área de pleno sol foram maiores quando as minicepas receberam as soluções de fertirrigação S100 e S50 associada a presença de AIB na concentração de 2 g.L-1. Os menores índices de enraizamento e os maiores de calos ocorreram nas miniestacas advindas de minicepas tratadas com a solução S25 na ausência da aplicação de AIB. Na enxertia, o melhor tratamento em relação à sobrevivência dos enxertos, tanto aos 45, quanto aos 200 dias foi a combinação de TKK (92%), seguido pela combinação TSK (52%), TSS (48%). Não houve pegamento nos enxertos de TKS, demonstrando incompatibilidade entre as espécies ao usar esse tipo de enxertia. Para a alporquia, as mudas tratadas com solução S100 e S50, seguidas de aplicação de AIB (3 g.L-1 ou 8 g.L-1) apresentaram os maiores percentuais de enraizamento. No tratamento com a solução S25 sem aplicação de AIB ocorreu maior formação de calos e menor de enraizamento. No geral, as três técnicas de propagação (miniestaquia, enxertia e alporquia) foram adequadas para a multiplicação de Khaya anthotheca, demostrando viabilidade para a produção de mudas.
Khaya anthotheca A. Juss. (Welw.) is a species of african mahogany that rises in brazilian scene as a promising alternative for forestation with species of hardwood. However, the high cost of its seeds and its short period of viability are some factors that hinder the provision seedlings in the market at affordable prices. The aim this research was to evaluate the efficiency of minicutting technique, grafting and air layering to establish an clonal propagation method for Khaya anthotheca. In the first experiment of minicutting, ministumps were treated with the following fertigation solutions: S100 - 100% of nutrient concentration (control solution), S50 - 50% of nutrient concentration and S25 - 25% of nutrient concentration. The experimental design was randomized complete block in a factorial arrangement (3x5) with split-plot in the time. The factors consisted of 3 fertirrigation solutions (S100, S50 and S25) and 5 propagules collection. Ministump survival and minicutting production were evaluated. In the second stage of the experiment, minicuttings were submitted to different nutrient solutions and part of them been treated with Indol-3-butyric acid - IBA (2 g.L-1) and other part was not treated with IBA (control). The experimental design was completely randomized in a factorial arrangement (3x5x2) with split-plot in time. The factors consisting of 3 fertirrigation solutions (S100, S50 and S25), 5 propagules collection and two IBA concentrations (A0 - without AIB, A2 - 2 g.L-1 IBA). Minicutting survival in greenhouse (SCV); minicutting survival in shade-house (SCS), adventitious rooting in full sun area (EAPS) and presence of callus (CAL) were evaluated. In the grafting, combinations of Khaya anthotheca and Swietenia macrophylla King. were tested (rootstock + graft): TSK - Swietenia macrophylla + Khaya anthotheca; TKS - Khaya anthotheca + Swietenia macrophylla; TSS - Swietenia macrophylla + Swietenia macrophylla; TKK - Khaya anthotheca + Khaya anthotheca. The experimental design was randomized complete block, with the treatments constituted by 4 grafting combination. The survival was evaluated at 45 and 200 days after the grafting, followed by histological analysis. The fourth experiment was performed air layering in seedlings of Khaya anthotheca. Seedlings were fertigated with solutions of S100, S50 and S25, and after 45 days, was performed air layering with application of three IBA concentrations (A0 - without IBA, control; A3 - 3 g.L-1 IBA and A8 - 8 g.L-1 AIB). The experimental design was randomized complete block in a factorial arrangement (3x3). The factors consist of 3 fertigation solutions and 3 IBA concentrations. Survival of ministumps did not vary significantly, regardless of shoots collection and nutrient solution. The S100 solution resulted in higher values of minicuttings production per square meter per year. The minicutting survival in the greenhouse was high, regardless of the shoots collection, nutrient solution and IBA application. The minicuttings survival in shade house and rooting in full sun area were xiv higher when treated with S100 and S50 solutions and application of 2 g.L-1 de IBA. The S25 solution in the IBA absence resulted in low rooting index and greater callogenesis index. In grafting, the best survival (45 and 200 days) was the TKK combination (92%), followed by the TSK (52%) and TSS (48%). There wasn’t survival in grafting of TKS, indicating incompatibility. For air layering, the seedlings treated with S100 and S50 solutions and AIB application (3 g.L-1 and 8 g.L-1) showed the highest adventitious rooting percentage. The S25 solution without IBA application increased the callus formation and low adventitious rooting. The three propagation techniques (i.e., minicutting, grafting and air layering) were suitable for multiplication of Khaya anthotheca, demonstrating feasibility for the clone production.
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Putivisutisak, Sompong. "Computation of heat transfer and flow in compact heat-exchanger geometries." Thesis, Imperial College London, 1999. http://hdl.handle.net/10044/1/8536.
Повний текст джерела
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Benson, James Martin. "A Buberian analysis of the education of artists : student-teacher relationships in the undergraduate studio." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://spectrum.library.concordia.ca/697/1/NQ43570.pdf.
Повний текст джерелаАнотація:
This study has two purposes: The first is to understand what takes place in the relationships between undergraduate studio teachers and students that often results in preventing authentic artistic existence. The second purpose is to understand the underlying assumptions of subjectivist and objectivist types of studio instructors and the potential for the attainment of authenticity in the relationships they have with their students. Martin Buber's concept of the dialogical I-Thou relationship is the basis for both his critique of subjectivist and objectivist educational traditions and his concept of authentic artistic existence. Buber's concept of dialogue is used first to analyze the relationships between teachers and students, then between artists and their artwork, and finally between studio instructors and their students. For the latter, the analysis utilizes examples from the author's own experiences as a student and also a studio teacher. Art education literature that presumably has had some impact/influence on artists/studio instructors is reviewed. The assumptions found in the literature are compared and contrasted to Buber's concept of the I-Thou relationship between the teacher and the student, and between the artist and the artwork. In contrast to the I-Thou, the literature tends to view the teacher or the artist in an I-It relationship, that is, as an active participant acting on a passive, dependent partner-the student or the artwork, respectively. Buber's concepts are then applied to the thesis purpose. Two pairs of metaphors are constructed to examine and critique subjectivist and objectivist instructors and students: the Magician-acolyte and the Matchmaker-debutante respectively. It is concluded that both types of relationships are exemplars of Buber's I-It relationship. Instructors who present themselves as subjectivist or objectivist exclusively, prevent dialogue. Consequently, students respond with an I-It, inauthentic existence. A model for a relationship that would result in authentic artistic existence for both participants is proposed. The metaphor of mentor-protégé, based on Buber's dialogic is presented as an alternative to the I-It experience.
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Trevisan, André Luis. "Prova em fases e um repensar da prática avaliativa em matemática." Universidade Estadual de Londrina, 2013. http://repositorio.utfpr.edu.br/jspui/handle/1/697.
Повний текст джерелаАнотація:
Este texto tem por objetivo apresentar reflexões oriundas da utilização da prova em fases como instrumento de avaliação em aulas de Matemática, em uma turma de Educação Profissional de Nível Médio. Para isso, apresentamos inicialmente uma descrição pormenorizada da experiência, tomada inicialmente como um “fracasso”, mas aos poucos percebida como fundamental na modificação na própria prática pedagógica. Nesse processo, a atitude passiva frente a uma avaliação em que se busca medir o quanto de uma técnica ou algoritmo é reproduzida pelo estudante foi aos poucos “caindo por terra”. A apresentação das percepções dos estudantes frente a um instrumento diferenciado de avaliação, bem como uma análise de sua produção escrita em questões da prova trouxeram elementos que permitiram analisá-lo criticamente. Partindo de considerações a respeito de algumas “falhas” na sua elaboração e implementação, analisamos as questões que compuseram a prova, à luz da abordagem conhecida como Educação Matemática Realística, buscando refletir também a respeito do conteúdo matemático subjacente às questões (a Trigonometria). Esse repensar aparece segundo três focos: os itens que compuseram a prova, o conteúdo matemático subjacente a esses itens e as próprias atitudes enquanto professor de Matemática. Ao longo de todo o texto, organizado segundo uma estrutura que busca preservar, em essência, o modo como a pesquisa foi sendo “tecida”, procuramos sempre contrapor criticamente o que “foi feito” com aquilo que “poderia ter sido feito”, numa tentativa constante de repensar a própria prática avaliativa.This text aims to present reflections arising out of the use of stage test as an assessment instrument in mathematics lessons, in a Middle Level Professional Education class. For this, we first present a detailed description of the experiment, taken initially as a "failure”, but gradually perceived as fundamental in the change in our own pedagogical practice. In this process, my passive attitude against assessment that tries to measure how much of a technique or algorithm is reproduced by a student was, gradually, "falling apart". Presenting the perceptions of students facing a differentiated assessment instrument, as well as an analysis of their written production in answering the questions, brought elements that made possible to examine the stage test critically. Starting from considerations about some "flaws" in its preparation and implementation, we analyze the questions of the examination using the approach known as Realistic Mathematics Education, also seeking for reflections about the underlying mathematical content issues (Trigonometry). This rethink appears according to three foci: the items that composed the test, the underlying mathematical content to these items and the own attitudes as teacher of Mathematics. Throughout the text, organized according to a structure that seeks to preserve, in essence, the way the research was being done, we always tried to oppose critically what was done with what could have been done in a constant attempt to rethink our own assessment practice.
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Boswell, Michael John. "Gas engines for domestic engine-driven heat pumps." Thesis, Oxford Brookes University, 1992. http://radar.brookes.ac.uk/radar/items/37f7ed18-4b86-6ab3-8ba6-1c27947fb1ce/1.
Повний текст джерелаАнотація:
An experimental and theoretical investigation has been undertaken into the performance of a small prototype, water-cooled, gas-fuelled engine designed for use as a domestic heat pump prime mover. In light of the application, fuel type and capacity, both experimental and theoretical study of similar engines is at best poorly documented in the literature. A comprehensive engine test facility has been set up, incorporating extensive calorimetry, a separate lubrication system, emissions monitoring and high speed data acquisition for in-cylinder pressure measurement and analysis. Two new experimental cylinder heads have been designed together with new induction and exhaust systems, both to improve performance and to enable further investigation of the combustion process. A preliminary parametric study of the combustion process established that the thermal efficiency and emission levels are strongly dependent on operational and design variables and that a lean, fast-burning combustion process in a slow speed engine coupled with careful control of other operating variables had the potential for improving efficiency, reducing emissions, and lowering frictional losses and noise levels with enhanced durability. Accordingly, new information has been obtained relating to rates of heat release, energy flows and emission levels over a wide range of design and operating conditions with utility for and consistent with an envelope of conditions appropriate to such a lean burn strategy. Modelling techniques have been developed and used as diagnostic tools in conjunction with the experimental data to investigate the influence of operating and design variables on rates of heat release and energy flows. The models have been validated using the experimental data over a wide range of operating conditions and incorporated into a thermodynamic engine model for use as a sub-model in an overall heat pump model. The experimental and theoretical programme has provided a valuable insight into the lean burn strategy and realised a considerable improvement in the performance of the prototype engine. The theoretical study benefits from a new approach to small gas engine design and development.
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SILVA, Gelda Alves da. "Atuação dos profissionais dos serviços em Saúde Mental de Goiânia - GO." Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tde/697.
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Previous issue date: 2010-04-30La investigación basada en las recomendaciones de la OPS y la OMS para evaluar el cuidado de la salud mental en las Américas. Integra un proyecto de investigación multicéntrico coordinado por la Escuela de Enfermería de Ribeirão Preto de la Universidad de São Paulo, en colaboración con la Escuela de Enfermería, Universidad Federal de Goiás, para realizar estudios de diagnóstico sobre el cuidado de la salud mental en Brasil. Se trata de una pesquisa descriptivo-exploratoria de abordaje cali-cuantitativa, desarrollada en la Rede Especializada en Salud Mental da Secretaria Municipal de Salud de Goiania (RESM/SMS/GO), a saber: 01 Unidad de Generación de Renda, 07 CAPS (Centro de Atención Psicosocial), 01 Ambulatorio Municipal de Psiquiatra y 01 Unidad de Urgencia y Emergencia Psiquiátrica. Tuve como objetivos presentar el perfil socioeconómico y la formación de los profesionales de nivel superior; identificar las acciones desarrolladas por las diferentes categorías profesionales y describir las acciones desarrolladas por los enfermeros. Los dados, obtenidos por medio de un cuestionario auto-aplicable direccionado a todos los profesionales y un otro específico a los enfermeros, fueron sometidos a evaluación temática de contenido (BARDIN, 1977) y a los testes estadísticos Qui-Cuadrado e Exacto de Fisher. La coleta de dados correó mientras los meses de abril a junio de 2009, obedeciendo a los procedimientos éticos en la pesquisa con seres humanos. Hicieron parte de la pesquisa 124 profesionales de nivel superior, el que corresponde a 52% do cuadro funcional, estando en los CAPS a mayor porcentaje de participación. Integraron el estudio 64% dos enfermeros actuantes e los servicios de la RESM/SMS/GO. Los resultados son descritos por medio de gráficos e tablas, trayendo inicialmente la caracterización de los participantes, conforme las categorías profesionales y sus respectivos servicios de sitio. En la secuencia, son presentadas las acciones desarrolladas por los profesionales, además de aquéllas realizadas pelos enfermeros. En medio de los atendimientos además citados entre los participantes están aquéllos vueltos a las familias y atendimientos grupales. Las acciones de los enfermeros fueran categorizadas en asistencias, educativas e gerenciales, quera sean desarrolladas individualmente ó en conjunto con otros profesionales. De modo general, los resultados dejan claro que las acciones profesionales aun son incipientes en relación a lo recomendado pela Política Nacional de Salud Mental, todavía los dados señalizan algunos avanzos en disponer estrategias y formas de atender los usuarios que buscan atendimiento en Salud Mental, los cuales son resultantes de las posibilidades y limitaciones de cada servicio. A concluir esta investigación, recomienda-se que sus resultados sean pensados por las instituciones formadoras, además de los gestores e profesionales involucrados en la asistencia de forma a suscitar posibles innovaciones en el atendimiento en Salud Mental en el País.
Investigação baseada em uma das recomendações da OPAS e OMS em avaliar a assistência em saúde mental nas Américas. Integra um projeto de pesquisa multicêntrico coordenado pela Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo em parceria com a Faculdade de Enfermagem da Universidade Federal de Goiás, visando realizar estudos diagnósticos sobre assistência em saúde mental no Brasil. Trata-se de uma pesquisa descritivo-exploratória de abordagem quali-quantitativa, desenvolvida na Rede Especializada em Saúde Mental da Secretaria Municipal de Saúde de Goiânia (RESM/SMS/GO), a saber: 01 Unidade de Geração de Renda, 07 CAPS (Centro de Atenção Psicossocial), 01 Ambulatório Municipal de Psiquiatria e 01 Unidade de Urgência e Emergência Psiquiátrica. Teve como objetivos apresentar o perfil sócio-econômico e de formação dos profissionais de nível superior; identificar as ações desenvolvidas pelas diferentes categorias profissionais e relacionar as ações desenvolvidas pelos enfermeiros. Os dados, obtidos por meio de um questionário auto-aplicável direcionado a todos os profissionais e um outro específico aos enfermeiros, foram submetidos à analise análise temática de conteúdo (BARDIN, 1977) e aos testes estatísticos Qui-Quadrado e Exato de Fisher. A coleta de dados ocorreu entre os meses de abril a junho de 2009, obedecendo aos procedimentos éticos na pesquisa com seres humanos. Fizeram parte da pesquisa 124 profissionais de nível superior, o que corresponde a 52% do quadro funcional, sendo nos CAPS a maior porcentagem de participação. Integraram o estudo 64% dos enfermeiros atuantes nos serviços da RESM/SMS/GO. Os resultados são descritos por meio de gráficos e tabelas, trazendo inicialmente a caracterização dos participantes, conforme as categorias profissionais e seus respectivos serviços de lotação. Na seqüência, são apresentadas as ações desenvolvidas pelos profissionais, além daquelas realizadas pelos enfermeiros. Dentre os atendimentos mais citados entre os participantes estão aqueles voltados às famílias e atendimentos grupais. As ações dos enfermeiros foram categorizadas em assistênciais, educativas e gerenciais, quer sejam desenvolvidas individualmente ou em parceria com outros profissionais. De modo geral, os resultados deixam claro que as ações profissionais ainda são incipientes em relação ao recomendado pela Política Nacional de Saúde Mental, embora os dados sinalizam alguns avanços em disponibilizar estratégias e formas de atender os usuários que buscam atendimento em Saúde Mental, os quais são resultantes das possibilidades e limitações de cada serviço. Ao concluir esta investigação, recomenda-se que seus resultados sejam refletidos pelas instituições formadoras, além dos gestores e profissionais envolvidos na assistência de forma a suscitar possíveis inovações no atendimento em Saúde Mental no País.
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Rodrigues, Ana Carina Pita. "Relatório de estágio apresentado à Universidade da Madeira para obtenção do grau de mestre em Educação Pré-Escolar e Ensino do 1º Ciclo do Ensino Básico." Master's thesis, 2014. http://hdl.handle.net/10400.13/697.
Повний текст джерелаАнотація:
O presente relatório foi elaborado para obtenção do grau de mestre em Educação Pré-
Escolar e Ensino do 1.º Ciclo do Ensino Básico. O mesmo constrói-se em torno da práxis pedagógica desenvolvida no contexto da Educação de Infância, na Escola Básica do 1.º Ciclo com Pré-Escolar do Areeiro, com um grupo de crianças de 2, 3 e 4 anos.
O corpus do relatório congrega, numa primeira parte, um enquadramento teórico e
metodológico que fundamenta toda a ação pedagógica. Numa segunda parte apresenta-se a
intervenção pedagógica in loco apoiada no percurso metodológico da investigação-ação. O
desejo profundo de melhorar a qualidade da intervenção pedagógica e a necessidade, para tal, de investigar levou-nos a adotar uma metodologia de investigação-ação que, impulsionando a dimensão reflexiva e investigativa do educador, permitiu dar resposta a algumas indagações.
No decorrer da práxis procurou-se envolver as crianças numa aprendizagem experiencial de forma a fomentar aprendizagens com significado, partindo da visão da criança como um ser com competência para participar no processo de construção da sua aprendizagem. Estas são as linhas centrais do processo de edificação da intencionalidade
educativa, as quais aspiram a uma pedagogia-em-participação que colabore no
desenvolvimento dos níveis de implicação e bem-estar emocional das crianças.
No final, é feita uma reflexão crítica de todo o estágio, destacando a sua importância
para o desenvolvimento da identidade profissional neste contexto de formação inicial, admitindo de antemão que a identidade é revelada enquanto caminho. E o caminho faz-se a caminhar… num percurso de procura sempre inacabado.
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Dritsa, Maria. "Essai clinique randomisé sur les effets de l'exercice dans la réduction de la fatigue chez les femmes atteintes de dépression post-partum." Thèse, 2007. http://www.archipel.uqam.ca/697/1/D1616.pdf.
Повний текст джерелаАнотація:
L'objectif principal de cette étude était d'évaluer l'efficacité d'un programme d'entraînement physique fait à la maison pour diminuer la fatigue physique et mentale chez les femmes en dépression post-partum. Les objectifs secondaires étaient d'explorer les modérateurs et médiateurs de l'effet des exercices à la maison sur la diminution des scores de fatigue physique et mentale. Quatre-vingt-huit femmes dans la période post-partum (4-38 semaines) ayant obtenu un score ≥10 sur l'échelle de dépression postnatale d'Edinburgh (EPDS) ont été recrutées. Les participantes ont été réparties de façon aléatoire dans le groupe d'intervention (n=46) ou dans le groupe contrôle (n=42). Les femmes du groupe intervention ont participé à un programme d'exercice à domicile supervisé pendant 12 semaines. Toutes les participantes ont complété le test de condition physique cardiovasculaire à l'entrée dans l'étude et en post-traitement. Les participantes ont complété une série de questionnaires mesurant les résultats (fatigues physique et mentale) de même que des variables médiatrices et modératrices potentielles à l'entrée dans l'étude, en post-traitement et 3 mois post-traitement. Basé sur le principe de l'analyse en intention de traiter, les femmes dans le groupe d'exercice sont comparées aux femmes du groupe contrôle et montrent de façon significative, une plus grande diminution de la fatigue physique en post-traitement et à 3 mois post-traitement. Avec l'exercice, on a observé chez les femmes ayant rapporté peu de fatigue physique à l'entrée dans l'étude, une diminution significative de la fatigue mentale en post-traitement. Selon les résultats des régressions linéaires hiérarchiques sur les variables modératrices de l'effet des exercices sur la fatigue physique, les femmes qui commencent à s'entraîner après approximativement 9 semaines post-accouchement et celles avec une meilleure condition physique cardiovasculaire initiale ont montré de plus grandes réductions de la fatigue physique grâce à l'exercice. La sévérité de la dépression au moment de l'entrée dans l'étude n'a pas modéré les effets de l'exercice sur la fatigue physique. Les régressions linéaires hiérarchiques évaluant les variables modératrices de l'intervention sur la fatigue mentale ont montré que l'intervention est efficace pour les femmes qui sont entrées dans l'étude à une période post-partum plus tardive et pour les femmes avec des scores de dépression élevés. La diminution du stress perçu et l'augmentation de la dépense énergétique reliée à l'exercice ont été identifiées comme variables médiatrices des diminutions de la fatigue physique grâce à l'exercice. Dans la période post-partum, la fatigue est un symptôme couramment vécu, et elle peut être amplifiée par la dépression. Ces découvertes montrent que chez les femmes déprimées dans la période post-partum, l'exercice fait à la maison peut réduire les fatigues physique et mentale. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : Dépression post-partum, Fatigue, Exercice physique.
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Labrie, Isabelle. "Impact du style personnel de communication au travail sur la compétence communicationnelle des étudiants-gestionnaires de MBA de l'ensemble du réseau de l'Université du Québec." Thèse, 2003. http://constellation.uqac.ca/697/1/18043210.pdf.
Повний текст джерелаАнотація:
Le but de cette recherche scientifique comporte deux volets : d'abord vérifier l'existence d'un lien entre le style personnel de communication au travail et la compétence communicationnelle. Secundo, vérifier la corrélation entre les deux outils de mesure de la compétence communicationnelle utilisés dans cette étude. La revue de littérature a permis de générer un cadre conceptuel riche et diversifié et a permis de donner naissance à un cadre théorique basé sur des références dans le domaine de la compétence communicationnelle. Ainsi, cette étude prend assise sur la théorie de Cormier (2000) en ce qui concerne le style personnel de communication au travail et sur les études de McCroskey (1984, 1988) et Duran (1983, 1992) sur la compétence en communication. Cette recherche cible les cadres puisqu'ils représentent depuis longtemps une population de choix pour les chercheurs (Mintzberg, 1973) en particulier les cadres en formation puisqu'elle a interrogé des étudiants de MBA des universités du réseau de l'Université du Québec offrant le programme de MBA pour cadres: l'UQAR, l'UQAC, l'UQO, l'UQAM, l'UQAT procurant ainsi un échantillon de 225 participants répartis sur l'ensemble du Québec.
La problématique de cette recherche met en lumière que toute personne qui entre en communication arbore un style de communication. Il semble que le développement des habiletés reliées à la compétence communicationnelle soit tributaire du style personnel de communication. Ainsi, il devient pertinent de pousser plus loin l'analyse et de vérifier s'il y a un style de communicateur qui semble faire preuve d'une plus grande compétence en communication. L'utilisation de la « Self perceived communication competence » et la « Communicative adaptability scale » vise à démontrer si effectivement il y a un style de communicateur parmi les quatre styles fondamentaux identifiés par Cormier (2000) qui soit plus efficace en communication. Les deux échelles de mesure permettent de voir, selon la vision de la compétence communicationnelle des deux concepteurs : s'il y a un style de communicateur qui semble avoir une meilleure perception de lui en tant qu'être communicationnel, perception qui influence ses choix de comportements et d'attitudes de communication (McCroskey, 1984), et s'il y a un style de communicateur qui semble avoir une meilleure habileté à s'adapter à différents contextes sociaux de communication de façon à user d'une communication juste et appropriée (Duran, 1983,1992).
Par le biais des méthodes quantitatives les données ont été analysées à l'aide de l'analyse de variance à un facteur et à l'aide de la corrélation linéaire. Les résultats des analyses statistiques infirment la première hypothèse à l'effet que le style de communicateur a un impact sur la compétence en communication. Par contre, la deuxième hypothèse est confirmée et démontre qu'il y a effectivement une corrélation entre les deux outils de mesure de la compétence en communication (SPCC, McCroskey, 1984 ; CAS, Duran, 1983). Toutefois, l'étude dénote un phénomène intéressant ce qui constitue à notre avis un apport significatif à l'étude de la compétence communicationnelle auprès des managers : les femmes cadres semblent démontrer une perception plus positive de leur compétence communicationnelle que leurs homologues masculins.
Книги з теми "697,1, 697.27"
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Duque, Gustavo, and Douglas P. Kiel, eds. Osteoporosis in Older Persons. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84628-697-1.
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Agung, Indonesia Mahkamah. Putusan-putusan Mahkamah Agung tgl. 7-1-1982 no. 471 K/Kr/1979, tgl. 11-1-1982 no. 697 K/Kr/1980, tgl. 7-1-1982 no. 108 K/Kr/1981: Ukuran hukuman dalam kasasi. [Jakarta]: Mahkamah Agung, Proyek Yurisprudensi, 1988.
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3
Handwerger, Stuart, ed. Molecular and Cellular Pediatric Endocrinology. Totowa, NJ: Humana Press, 1999. http://dx.doi.org/10.1007/978-1-59259-697-3.
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Gomer, Charles J., ed. Photodynamic Therapy. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-697-9.
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Askari, Kaveh. Making Movies into Art. London: British Film Institute, 2014. http://dx.doi.org/10.1007/978-1-84457-697-5.
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Loriaux, Lynn, ed. Endocrine Emergencies. Totowa, NJ: Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-697-9.
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Hoyland, Robert G. Theophilus of Edessa's Chronicle and the Circulation of Historical Knowledge in Late Antiquity and Early Islam. 4 Cambridge Street, Liverpool, L69 7ZU: Liverpool University Press, 2011. http://dx.doi.org/10.3828/978-1-84631-697-5.
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Parks, United States Congress Senate Committee on Energy and Natural Resources Subcommittee on National. Miscellaneous national parks legislation: Hearing before the Subcommittee on National Parks of the Committee on Energy and Natural Resources, United States Senate, One Hundred Tenth Congress, first session, on S. 128, S. 148, S. 189, S. 697, S. 867, S. 1039, S. 1341, S. 1476, S. 1709, S. 1808, S. 1969, H.R. 299, H.R. 1239, September 27, 2007. Washington: U.S. G.P.O., 2008.
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United States. Congress. Senate. Committee on Energy and Natural Resources. Subcommittee on National Parks. Miscellaneous national parks legislation: Hearing before the Subcommittee on National Parks of the Committee on Energy and Natural Resources, United States Senate, One Hundred Tenth Congress, first session, on S. 128, S. 148, S. 189, S. 697, S. 867, S. 1039, S. 1341, S. 1476, S. 1709, S. 1808, S. 1969, H.R. 299, H.R. 1239, September 27, 2007. Washington: U.S. G.P.O., 2008.
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Miscellaneous national parks legislation: Hearing before the Subcommittee on National Parks of the Committee on Energy and Natural Resources, United States Senate, One Hundred Tenth Congress, first session, on S. 128, S. 148, S. 189, S. 697, S. 867, S. 1039, S. 1341, S. 1476, S. 1709, S. 1808, S. 1969, H.R. 299, H.R. 1239, September 27, 2007. Washington: U.S. G.P.O., 2008.
Знайти повний текст джерелаЧастини книг з теми "697,1, 697.27"
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Doggett, J. Stone, and Brian Wong. "Malignant (Necrotizing) Otitis Externa." In Endocrine Emergencies, 49–55. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_5.
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Doggett, J. Stone, and Brian Wong. "Mucormycosis." In Endocrine Emergencies, 57–63. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_6.
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Doggett, J. Stone, and Brian Wong. "Emphysematous Cholecystitis." In Endocrine Emergencies, 65–69. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_7.
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Wong, Brian, and J. Stone Doggett. "Emphysematous Pyelonephritis." In Endocrine Emergencies, 71–76. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_8.
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Reyes-Castano, John J., and Kenneth Burman. "Thyrotoxic Crisis: Thyroid Storm." In Endocrine Emergencies, 77–97. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_9.
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Loriaux, Lynn. "Acute Adrenal Insufficiency." In Endocrine Emergencies, 1–14. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_1.
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Donangelo, Ines, and Glenn D. Braunstein. "Myxedema Coma." In Endocrine Emergencies, 99–108. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_10.
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Doggett, J. Stone, and Brian Wong. "Acute Suppurative Thyroiditis." In Endocrine Emergencies, 109–13. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_11.
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Ellison, David H. "Hyponatremia: SIADH." In Endocrine Emergencies, 115–26. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_12.
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Ellison, David H. "Diabetes Insipidus." In Endocrine Emergencies, 127–38. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-697-9_13.
Повний текст джерелаТези доповідей конференцій з теми "697,1, 697.27"
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MacDonald, Robert L., Pan-Pan Jiang, Julie Cattiau, Rus Heywood, Richard Cave, Katie Seaver, Marilyn A. Ladewig, et al. "Disordered Speech Data Collection: Lessons Learned at 1 Million Utterances from Project Euphonia." In Interspeech 2021. ISCA: ISCA, 2021. http://dx.doi.org/10.21437/interspeech.2021-697.
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Schmidt, O., C. Wirth, S. Rhein, M. Rekas, A. Kliner, T. Schreiber, R. Eberhardt, and A. Tunnermann. "697 W 12 pm linewidth of fiber generated and amplified spontaneous emission (ASE) at 1 µm." In 12th European Quantum Electronics Conference CLEO EUROPE/EQEC. IEEE, 2011. http://dx.doi.org/10.1109/cleoe.2011.5943107.
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Check, Jerome H., Diane Check, Trina Poretta, James Aikins, and Carrie Wilson. "Abstract 697: Improvement in quality and length of life following treatment with mifepristone in women with stage IV non-small cell lung cancer, positive for the epidermal growth factor receptor (EGFR) mutation, that previously progressed on targeted therapy." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-697.
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Zhang, Wendong, Michael E. Roth, Jonathan Gill, Sajida Piperdi, E. Anders Kolb, David S. Geller, Bang Hoang, Rui Yang, and Richard Gorlick. "Abstract 697: Stage 1in vivoevaluation of multi-receptor tyrosine-kinase inhibitor lenvatinib in osteosarcoma patient derived mouse xenograft models." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-697.
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Santos, J. N. B., I. S. Nascimento, M. A. Grugiki, and M. F. Pompelli. "Caracterização e análise comparativa entre métodos de estimativa de área foliar de Bauhinia cheilantha (Bong.)." In VIII Simpósio Brasileiro de Pós-Graduação em Ciências Florestais. Recife, Pernambuco, Brasil: Universidade Federal Rural de Pernambuco, 2014. http://dx.doi.org/10.12702/viii.simposfloresta.2014.50-697-1.
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Akoglu, Leman. "Anomaly Mining - Past, Present and Future." In Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California: International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/697.
Повний текст джерелаАнотація:
Anomaly mining is an important problem that finds numerous applications in various real world do- mains such as environmental monitoring, cybersecurity, finance, healthcare and medicine, to name a few. In this article, I focus on two areas, (1) point-cloud and (2) graph-based anomaly mining. I aim to present a broad view of each area, and discuss classes of main research problems, recent trends and future directions. I conclude with key take-aways and overarching open problems. Disclaimer. I try to provide an overview of past and recent trends in both areas within 4 pages. Undoubtedly, these are my personal view of the trends, which can be organized differently. For brevity, I omit all technical details and refer to corresponding papers. Again, due to space limit, it is not possible to include all (even most relevant) references, but a few representative examples.
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Yang, Yanping, Jaclyn E. McCloskey, Yogindra Vedvyas, Irene M. Min, Eric von Hofe, and Moonsoo M. Jin. "Abstract 6597: Highly localized, inducible interleukin-12 release augments ICAM-1 CAR T cell activity against solid tumors." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-6597.
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Bergeles, Konstantinos, Georgios Charalampous, Yannis Hardalupas, and Alex M. Taylor. "Effect of liquid viscosity on the aerodynamic breakup of non-spherical droplets." In ILASS2017 - 28th European Conference on Liquid Atomization and Spray Systems. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/ilass2017.2017.4675.
Повний текст джерелаАнотація:
This paper studies the effect of liquid viscosity on the atomisation regimes of initially spherical and non-sphericaldroplets and also kinematic characteristics of non-spherical droplets. The droplets consisted of water-glycerolsolutions with viscosities ranging from 6.3 to 697 mPa s, and the initial aspect ratio was 1<AR<2. The range of Wenumber was from 10 to 200 and of the Oh number from 0.01 to approximately 4. The experimental findings showedthat the equivalent Weeq and Oheq numbers, proposed in previous work [1] for water droplets, are also applicableto spherical and non-spherical droplets in the range of Oh numbers of this study in order to classify the breakupregimes on the existing morphological charts. The kinematic characteristics of the centre of mass for droplets withAR=1.2 are evaluated and the role of viscosity examined in the no breakup and bag-stamen regimes.DOI: http://dx.doi.org/10.4995/ILASS2017.2017.4675
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Zhezmer, Natalya. "Economic efficiency of long-term multi-mowing use of different-ripening grass stands for haylage harvesting." In Multifunctional adaptive fodder production. ru: Federal Williams Research Center of Forage Production and Agroecology, 2021. http://dx.doi.org/10.33814/mak-2021-25-73-87-93.
Повний текст джерелаАнотація:
The economic assessment of the three-mowing technology for harvesting grass raw materials for haylage was carried out on the basis of new methodological approaches. The total costs (50.5–53.9 thousand rubles/ha) for the creation and use of promising different-ripening grass stands paid off in 1.6 years. In the next 3–27 years of grass life, due to the productive longevity of agrocenoses, 19.1–25.0 thousand rubles/ha of conditional net income were received. The cost of 1 feed unit was 5.2–5.8 rubles with a production margin of 69–87%.
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Keller, R. R., R. H. Geiss, Y. W. Cheng, and D. T. Read. "Microstructure Evolution During Alternating-Current-Induced Fatigue." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61291.
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Subjecting electronic interconnect lines to high-density, low-frequency alternating current creates cyclic thermomechanical stresses that eventually cause electrical failure. A detailed understanding of the failure process could contribute to both prevention and diagnostics. We tested unpassivated Al-1Si traces on the NIST-2 test chip; these are 3.5 μm wide by 0.5 μm thick by 800 μm long, with a strong (111) as-deposited fiber texture and an initial average grain diameter of approximately 1 μm. We applied rms current densities of 11.7 to 13.2 MA/cm2 at 100 Hz. Resistance changes in the lines indicated that such current densities produce temperature cycles at 200 Hz with amplitude exceeding 100 K. Open circuits occurred in under 10 minutes, with substantial surface damage seen after only one minute. A few failures initiated at lithography defects initially present in the lines, but most were produced by the current alone. In one detailed example presented in this paper, we monitored the damage process by interrupting the current at 10, 20, 40, 80, 160, and 320 s in order to characterize an entire line by scanning electron microscopy and automated electron backscatter diffraction (EBSD); failure took place after 697 s. Results are described in terms of deformation, grain growth, and orientation changes.
Звіти організацій з теми "697,1, 697.27"
1
Ama Pokuaa, Fenny, Aba Obrumah Crentsil, Christian Kwaku Osei, and Felix Ankomah Asante. Fiscal and Public Health Impact of a Change in Tobacco Excise Taxes in Ghana. Institute of Development Studies (IDS), November 2020. http://dx.doi.org/10.19088/ictd.2020.003.
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This working paper predicts the fiscal and public health outcomes from a change in the excise tax structure for cigarettes in Ghana. More than 5,000 people are killed by diseases caused by tobacco every year in Ghana (Tobacco Atlas 2018). Currently the country has a unitary tax administration approach, with a uniform ad valorem tax structure on all excisable products, including tobacco. However, the ECOWAS directive on tobacco control, in line with the WHO Framework Convention on Tobacco Control (WHO 2003), recommends a simple tax structure – using a mixed excise system with a minimum specific tax floor to overcome the limitations of an ad valorem system on tobacco products, especially cigarettes. The study therefore simulates mixed tax policy interventions, and assesses their effect on government revenue and public health relative to the current ad valorem tax system. Primary data collection of tobacco prices in three geographical zones of the country was conducted in February 2020, across both rural and urban localities. This was supported with secondary data from national and international databases. Based on the assumption that Ghana adopts a mixed tax structure, the simulation shows that, if the government imposes a specific excise tax of GH₵4.00 (US$0.80) per pack in addition to the current ad valorem rate of 175 per cent of the CIF value, the average retail price of a cigarette pack would increase by 128 per cent, cigarette consumption decrease by 27 per cent, tobacco excise tax revenue increase by 627 per cent, and overall tobacco-related government tax revenue increase by 201 per cent.1 Additionally, there would be significant declines in smoking prevalence (3.3%), smoking intensity (1,448 cigarettes per year), and 3,526 premature smoking-related deaths would be avoided. The paper advocates for a strong tax administration and technical capacity, with continuous commitment by the government to adjust the tax rate in line with the rate of inflation and per capita income growth.
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Goetsch, Arthur L., Yoav Aharoni, Arieh Brosh, Ryszard (Richard) Puchala, Terry A. Gipson, Zalman Henkin, Eugene D. Ungar, and Amit Dolev. Energy Expenditure for Activity in Free Ranging Ruminants: A Nutritional Frontier. United States Department of Agriculture, June 2009. http://dx.doi.org/10.32747/2009.7696529.bard.
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Heat production (HP) or energy expenditure for activity (EEa) is of fundamental nutritional importance for livestock because it determines the proportion of ingested nutrients available for productive functions. Previous estimates of EEa are unreliable and vary widely with different indirect methodologies. This leads to erroneous nutritional strategies, especially when intake on pasture does not meet nutritional requirements and supplementation is necessary for acceptable production. Therefore, the objective of this project was to measure EEa in different classes of livestock (beef cattle and goats) over a wide range of ecological and management conditions to develop and evaluate simple means of prediction. In the first study in Israel, small frame (SF) and large frame (LF) cows (268 and 581 kg) were monitored during spring, summer, and autumn. Feed intake by SF cows per unit of metabolic weight was greater (P < 0.001) than that by LF cows in both spring and summer and their apparent selection of higher quality herbage in spring was greater (P < 0.10) than that of LF cows. SF cows grazed more hours per day and walked longer distances than the LF cows during all seasons. The coefficient of specific costs of activities (kJ•kg BW-0.75•d-1) and of locomotion (J•kg BW-0.75•m-1) were smaller for the SF cows. In the second study, cows were monitored in March, May, and September when they grazed relatively large plots, 135 and 78 ha. Energy cost coefficients of standing, grazing, and horizontal locomotion derived were similar to those of the previous study based on data from smaller plots. However, the energy costs of walking idle and of vertical locomotion were greater than those found by Brosh et al. (2006) but similar to those found by Aharoni et al. (2009). In the third study, cows were monitored in February and May in a 78-ha plot with an average slope of 15.5°, whereas average plot slopes of the former studies ranged between 4.3 and 6.9°. Energy cost coefficients of standing, grazing, and walking idle were greater than those calculated in the previous studies. However, the estimated energy costs of locomotion were lower in the steeper plot. A comparison on a similar HP basis, i.e., similar metabolizable energy (ME) intake, shows that the daily energy spent on activities in relation to daily HP increased by 27% as the average plot slope increased from 5.8 and 6.02 to 15.5°. In the fourth study, cows grazing in a woodland habitat were monitored as in previous studies in December, March, and July. Data analysis is in progress. In the first US experiment, Boer and Spanish does with two kids were used in an experiment beginning in late spring at an average of 24 days after kidding. Two does of each breed resided in eight 0.5-ha grass/forb pastures. Periods of 56, 60, 63, 64, and 73 days in length corresponded to mid-lactation, early post-weaning, the late dry period, early gestation, and mid-gestation. EEa expressed as a percentage of the ME requirement for maintenance plus activity in confinement (EEa%) was not influenced by stocking rate, breed, or period, averaging 49%. Behavioral activities (e.g., time spent grazing, walking, and idle, distance traveled) were not highly related to EEa%, although no-intercept regressions against time spent grazing/eating and grazing/eating plus walking indicated an increase in EEa% of 5.8 and 5.1%/h, respectively. In the second study, animal types were yearling Angora doeling goats, yearling Boer wether goats, yearling Spanish wether goats, and Rambouilletwether sheep slightly more than 2 yr of age. Two animals of each type were randomly allocated to one of four pastures 9.3, 12.3, 4.6, and 1.2 ha in area. The experiment was conducted in the summer with three periods, 30, 26, and 26 days in length. EEa% was affected by an interaction between animal type and period (Angora: 16, 17, and 15; Boer: 60, 67, and 34; Spanish: 46, 62, and 42; sheep: 22, 12, and 22% in periods 1, 2, and 3, respectively (SE = 6.1)). EEa% of goats was predicted with moderate accuracy (R2 = 0.40-0.41) and without bias from estimates of 5.8 and 5.1%/h spent grazing/eating and grazing/eating plus walking, respectively, determined in the first experiment; however, these methods were not suitable for sheep. These methods of prediction are simpler and more accurate than currently recommended for goats by the National Research Council.