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1

Borba, Fernando Hernique, Leandro Pellenz, Francine Bueno, Bianca dos Santos Antes, and Jonas Jean Inticher. "Investigação da Toxicidade Aguda (Lactuca sativa) e da Degradação do Corante Índigo Carmim pelo Processo de Oxidação Foto-Fenton." Fronteiras: Journal of Social, Technological and Environmental Science 8, no. 2 (May 1, 2019): 307–32. http://dx.doi.org/10.21664/2238-8869.2019v8i2.p307-332.

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Este trabalho teve como objetivo avaliar a degradação do corante Índigo Carmim via processo foto-Fenton. A partir de uma metodologia de superfície de resposta foram investigadas as melhores condições experimentais de pH inicial (2,5 - 3,5), [H2O2] inicial (29,5 - 130,5 mg L-1) e [Fe2+] inicial (13,2 - 40 mg L-1). Para verificar a eficiência do processo foram analisadas as reduções da absorvância nos comprimentos de onda correspondentes aos picos de absorção do corante Índigo Carmim. A melhor performance do processo foto-Fenton foi observada em pH inicial 2,8, [H2O2] inicial de 29,5 mg L-1 e [Fe2+] inicial de 13,2 mg L-1, obtendo uma redução de absorvância de 74, 98, 85 e 100%, em 120 minutos para os comprimentos de 254 nm, 284 nm, 310 nm e 610 nm, respectivamente. Estes resultados indicaram uma significativa degradação do corante, observada especialmente na região de absorção do seu grupo cromóforo (610 nm). No entanto, bioensaios utilizando Lactuca sativa mostraram um aumento da toxicidade da solução tratada, sugerindo a formação de subprodutos intermediários mais tóxicos. Desta forma, se faz necessária a integração de um processo complementar ao foto-Fenton para a redução da toxicidade do corante Índigo Carmim, minimizando os impactos ambientais ocasionados pelo descarte inadequado destes compostos em corpos hídricos.
2

Nozaka, Takashi, Yoji Mizutani, Gun Bhakdisongkhram, Yuta Kawakami, Masahiro Echizen, Takashi Nishida, Hiroaki Takeda, Kiyoshi Uchiyama, and Tadashi Shiosaki. "Preparation of (Ba1-x, Srx)TiO3 Thin Films on Glazed Alumina Substrate and Improvement of Temperature Dependence of Dielectric Properties." Key Engineering Materials 421-422 (December 2009): 127–30. http://dx.doi.org/10.4028/www.scientific.net/kem.421-422.127.

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In this study, (Ba1-x,Srx)TiO3 thin films of various composition ratios were deposited on glazed Al2O3 substrates by the CSD method, and the temperature dependence of the dielectric property was analyzed. The dielectric property of the BST (80/20) thin film annealed at C was highly tunable, and the temperature dependence of the dielectric constant was stabilized at around room temperature. However, this BST (80/20) thin film exhibited intense ferroelectricity. Its tan intensified to 0.0511 in the high-frequency range (1 MHz). After the BST thin film was annealed at 600C, the grain size of the BST thin film was reduced to 40 nm and the ferroelectricity was alleviated. The dielectric constant, tan, and tunability of the BST thin film at 100 kHz were 158, 0.0170, and 39.6 (214 kV/cm, 6.0 V), respectively. The change rate of the dielectric constant, which indicates its temperature dependence, was ±7 or less in the range of -55 to 85C. Therefore, this BST thin film was considered to guarantee a wide operation temperature range for microwave tunable devices.
3

Pekur, D. V., Yu V. Kolomzarov, V. M. Sorokin, and Yu E. Nikolaenko. "Super powerful LED luminaires with a high color rendering index for lighting systems with combined electric power supply." Semiconductor Physics, Quantum Electronics and Optoelectronics 25, no. 1 (March 24, 2022): 97–107. http://dx.doi.org/10.15407/spqeo25.01.097.

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Considered in this paper are development and creation of high-power LED luminaires with high light efficiency and color rendering index (CRI). As light sources, there used are 6 powerful LED СОВ (Chip-on-Board) modules CreeCXA 2550, the radiation of which contains quasi-chromatic peaks in the spectral range 600…650 nm. It allows to provide CRI values higher than 92. Features of the improved compact construction of the luminaire with indicated COB modules have been presented. To ensure normal thermal regimes of LED COB modules, a small cooling system based on heat pipes has been created, the optimal dimensions of the structural elements of which have been determined by computer simulation. The results of modeling and experimental studies have shown that the developed and manufactured passive cooling system of LED COB modules provides operation temperature modes (up to 85 °C) of light-emitting crystals at the total electric power of COB modules up to 290 W and allows using the luminaires of this type in the systems of continuous artificial illumination with combined power supply. The efficiency of the developed cooling system at some angles to the horizon expands the scope of applying the illumination device.
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Ordinola Navarro, Alberto, Orestes de Jesús Cobos-Quevedo, Javier Cervantes-Bojalil, Esperanza Pérez Álvarez, Andrea González Gil, Ana Lilia Peralta-Amaro, Ana Laura Carrillo-González, et al. "High mortality at the beginning of the COVID-19 pandemic in a referral center in the metropolitan area of Mexico City." Journal of Infection in Developing Countries 16, no. 08 (August 30, 2022): 1269–77. http://dx.doi.org/10.3855/jidc.14389.

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Introduction: There is limited information about the coronavirus disease 2019 (COVID-19) disease in Latin-American countries. Our objective was to describe the clinical characteristics and outcomes of COVID-19 patients in Mexico. Methodology: We conducted a retrospective cohort study with 333 consecutive patients who were admitted to Hospital de Especialidades "Dr. Antonio Fraga Mouret" in Mexico City with COVID-19 between April 1, 2020, and June 30, 2020. Demographic, clinical, laboratory data, treatment details and 30-day outcomes were analyzed. Results: The patients studied included 52% men (172/233) and the median age was 45 years. Up to 75% (250/333) of patients were classified as overweight or obese. There were 185 (56%) inpatients; 85% (158/185) were hospitalized in the general ward, and 15% (27/185) in the Intensive Care Unit (ICU). Laboratory measurements showed significant differences between inpatients and outpatients such as lymphocyte-count (median 0.8 vs 1.2×109/L, p < 0.001), LDH (median 650 vs 294 U/L, p < 0.001), CRP (median 147 vs 5 mg/L, p = 0.007), CK-MB (median, 15 vs 10 U/L, p = 0.008), ferritin (median, 860 vs 392 ng/mL, p = 0.02), and D-dimer (median, 780 vs 600 ng/mL, p = 0.15). These differences were seen between survivor and non-survivor patients as well. The rate of death in mechanically ventilated patients was 94% (67/71). Mortality at 30-day follow-up was 57% (105/185). Conclusions: We observed that majority of the non-survivors were obese and young. Complications leading to death was observed in majority of the cases.
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Haferlach, Torsten, Manja Meggendorfer, Susanne Schnittger, Annette Fasan, Wolfgang Kern, and Claudia Haferlach. "Clinical Impact of Minimal Residual Disease (MRD) Monitoring in AML with PM-Rara, CBFB-MYH11, and RUNX1-RUNX1T1: A Study on 600 Patients." Blood 126, no. 23 (December 3, 2015): 228. http://dx.doi.org/10.1182/blood.v126.23.228.228.

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Abstract Introduction: The cure rate in AML is dependent on patient´s (pts) age and performance, cytogenetics, early blast clearance and sustainable first complete remission. Investigation of minimal residual disease (MRD) is possible by multiparameter flow cytometry and molecular techniques. Recent findings have further depicted a broad spectrum of molecular markers in AML in 99% of pts (TCGA, NEJM, 2013). This broadens the portfolio of targets for MRD assessment and will hopefully help to better individualize treatment strategies. We here focused - as a paradigm - on the three hallmarks for molecular MRD studies in AML. Aims: To better define the clinical impact and to suggest strategies for MRD monitoring in AML with PML-RARA, CBFB-MYH11, and RUNX1-RUNX1T1. Patients and Methods: Between 2005 und 2015 we at diagnosis investigated 321 PML-RARA, 134 CBFB-MYH11, and 145 RUNX1-RUNX1T1 AML pts. Individual follow-up time points during their course of disease were studied in 2657, 1047, and 890 samples, respectively. Thus, the combined number of investigated samples is 4,594. Molecular techniques applied comprised quantitative real-time PCR and nested PCR. Median age in PML-RARA was 52 years (yrs) (2-86 yrs), in CBFB-MYH11 53 yrs (21-81 yrs), and in RUNX1-RUNX1T1 52 yrs (10-83 yrs). Median time between 2 investigations was 3.0 months (mo) in PML-RARA, 2.1 mo in CBFB-MYH11, and 2.8 mo in RUNX1-RUNX1T1 pts (range for all 0.1-40.4 mo), respectively. All pts were treated with standard protocols according to genotype and age. Allogeneic bone marrow or stem cell transplantation was performed in 85 pts (14%). Results: 294/321 pts (92%) with PML-RARA achieved complete molecular remission (CMR) after a median of 2.9 mo (range: 0.8-9.7 mo). In contrast, in CBFB-MYH11 CMR was reached in 89/134 pts (66%) after a median of 7.4 mo (range: 1.6-16.8 mo), and in RUNX1-RUNX1T1 CMR was reached in 75/145 pts (51%) after a median of 4.7 mo (range: 1.0-11.5 mo). Of note, some of the CBFB-MYH11 pts never reached CMR, always showing low level signals. 95% (278/294) of PML-RARA pts that achieved CMR stayed in first CMR and did not relapse within a median follow-up of 32.6 mo (range: 1.2-134.5 mo). 5% (16/294) relapsed at a median interval after CMR of 8.1 mo. However, a second CMR was reached in 12/16 pts after relapse. Five of these 12 pts suffered from second relapses, whereof 4 pts achieved a third CMR. Third relapses occurred in 2/4 pts. 69/89 (78%) of pts with CBFB-MYH11 stayed in first CMR and never relapsed during a median follow-up of 10.4 mo (range: 1.6-47.1 mo). 20/89 relapsed after 4.0 mo of CMR, whereof 11 achieved second CMR. 3/11 relapsed again. 63/75 (84%) of pts with RUNX1-RUNX1T1 stayed in first CMR and never relapsed during a median follow-up of 10.1 mo (range: 1.0-65.8 mo). However, 12/75 relapsed after a median time of CMR of 5.3 mo. 4/12 achieved another CMR. In 85 patients (10 PML-RARA, 42 CBFB-MYH11, and 33 RUNX1-RUNX1T1) allogeneic bone marrow or stem cell transplantation (Tx) was performed, and 72/85 (85%) were rescued by Tx. However, two patients each with PML-RARA and RUNX1-RUNX1T1 relapsed, respectively, and 9 in CBFB-MYH11 positive AML after Tx. Patients did not experience first relapse later than 50.3 mo in CMR in PML-RARA, later than 30.7 mo in CBFB-MYH11, and later than 35.7 mo in RUNX1-RUNX1T1. Additionally, keeping periods between two MRD samplings at a maximum of 3 mo allowed the detection of nearly all cases of first relapse due to the molecular hint. Addressing the sensitivity levels of the assays applied to bone marrow (BM) versus peripheral blood (pB) samples showed a 1.4 fold higher sensitivity for BM samples (median copies of reference gene, 13,204 vs 9,240). Due to the comparable sensitivities pB can be investigated until a first hint of relapse, followed by BM sampling for confirmation. Conclusions: 1) MRD by molecular techniques reliably defines pts risks in AML with PML-RARA, CBFB-MYH11, and RUNX1-RUNX1T1, respectively. 2) Clinical decisions are reliable within screening intervals of 3 mo using pB. 3) Relapses in first CMR are not detected later than 50.3 mo in PML-RARA, 30.7 mo in CBFB-MYH11, and 35.7 mo in RUNX1-RUNX1T1 AML, respectively. 4) Pts after relapse can be rescued by transplantation in the majority of cases. 5) As the availability of other molecular markers in AML has dramatically increased, more individualized treatment strategies based on specific MRD monitoring are achievable in nearly every patient in the near future. Disclosures Haferlach: MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Meggendorfer:MLL Munich Leukemia Laboratory: Employment. Schnittger:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Fasan:MLL Munich Leukemia Laboratory: Employment. Kern:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership.
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СИДОРОВА, В. Ю. "THE RESULTS OF PUREBRED AND CROSSBRED BEEF CATTLE BREEDING’S IMITATION MODELING." Molochnoe i miasnoe skotovodstvo, no. 2 (April 15, 2023): 15–18. http://dx.doi.org/10.33943/mms.2023.80.12.004.

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В структуре производства крупного рогатого скота на мясные цели доля продукции от разведения чистопородного и помесного скота составляет около 20%. Цель исследования — определить особенности разведения чистопородного и помесного мясного скота, установить эффективность использования резервов при его разведении на мясные цели с применением инновационных технологий кормления и содержания. Модель воспроизводства стада — 284 (продолжительность стельности — постоянная величина) и 90 (сервис–период — изменяемая величина) — показала, что наиболее близкими к эффективному воспроизводству скота для мясных целей оказались животные мясного направления продуктивности с сезонными отелами. Вопрос влияния других различных элементов технологии выращивания на эффективность разведения чистопородных и помесных животных на откорме изучен недостаточно полно и требует уточнения. Результаты исследований, отражающие различия в технологии выращивания мясного скота, показали, что для определения эффективности разведения крупного рогатого скота различных конституциональных типов был разработан методический подход с математическим и логическим выражением регрессии признаков: f1/f2+m1/m2+g1/g2+(n∑y…u), где переменные g, m, f — математические, а остальные — логические признаки: при использовании резервов выращивания до 18-месячного возраста живая масса бычков черно-пестрой породы достигает 395,4 кг, помесных бычков — 431,5 кг, а абердин ангусских — 600—650 кг. In the cattle production for meat purposes’ structure , the share of products from both purebred and mixed cattle breeding reaches about 20%: for comparison, this figure in the USA and Canada reaches 70-75%, in Australia — 85%, in EU countries — 40—50%. The purpose of the study was the purebred and mixed beef cattle breeding features to determine, and in breeding effectiveness reserves for cattle for meat purposes with innovative technologies using for young animals’ feeding and keeping to establish. The herd reproduction model, which takes the form is: 284 (pregnancy duration — constant value) + 90 (service period — variable value) showed that the animals of the meat production with seasonal calving were the closest to the effective reproduction of livestock for meat purposes. At the same time, the issue of the influence of other various elements of the raising technology of purebred and crossbred animals breeding for fattening’s efficiency has not been studied fully enough and requires clarification. To determine the effectiveness of breeding various types of livestock, a methodological approach was developed, with a mathematical and logical expression of regression features: f1/f2 + m1/m2 +g1/g2 +(n∑y...u), where the variables g, m, f are mathematical, and the rest logical.The research results reflecting differences in the beef cattle raising technology, showed that reserves using for growing up to 18 months of age, black-and-white bulls reach a live weight of 395.4 kg, crossbred bulls — 431.5 kg, and Aberdeen-Angus bulls — 600—650 kg.
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Jones, Nadiá M., M. Gabriela Bernardo-Gil, and M. Graço Lourenco. "Comparison of Methods for Extraction of Tobacco Alkaloids." Journal of AOAC INTERNATIONAL 84, no. 2 (March 1, 2001): 309–16. http://dx.doi.org/10.1093/jaoac/84.2.309.

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Abstract Ultrasound and microwave techniques were used to extract tobacco alkaloids, and response surface methodology was used to optimize extraction conditions. Ultrasonic technique factors were temperature, 30–85°C; time, 3–45 min; solvent volume, 8–80 mL. Microwave extraction factors were pressure, 15–75 psi; time, 3–40 min; power, 30–90% of the maximum magnetron power of 650 W. Soxhlet and solvent AOAC-modified extraction methods were also applied after some improvements. Nicotine, nornicotine, anabasine, and anatabine were quantified by gas chromatography. A steam distillation International Standards Organization method for total alkaloid evaluation was used as reference. The results obtained by the different methods were compared using a least squares deviation test. The ultrasonic and the proposed modified-AOAC extraction method were the more convenient with regard to practicability and precision. The relative deviations (n = 5) were as follows: For the ultrasonic method in low-level alkaloid tobaccos, 0.7% nicotine and 1.4–14% minor alkaloids; in high-level alkaloid tobaccos, 2.4% nicotine and 4.5–5.1% minor alkaloids. For the modified AOAC method in low-level alkaloid tobaccos, 0.9% nicotine and 2.4–11.6% minor alkaloids; and in high-level alkaloid tobaccos, 1.7% nicotine and 2.0–2.4% minor alkaloids.
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Imanova, K., E. Haydarov, Yu Lezgiev, T. Musayev, and G. Aliyeva. "Research on the Rose Wines Production in Azerbaijan." Bulletin of Science and Practice, no. 12 (December 15, 2022): 264–71. http://dx.doi.org/10.33619/2414-2948/85/32.

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The native Matrasa grapes variety grown in the Samukh (79 m), Ganja (408 m) and Goygol (630 m) districts located at different altitudes above sea level, was used. Storage of pulp was carried out at different times — 3, 6, 12, 24 hours. Before maceration, desulfurization of the pulp is carried out. As a result of the tasting conducted according to a 10-point system with the participation of 9 tasters, a sample of rose wine aged in a pulp for 6 hours became more noticeable due to its transparency and color. At the same time, in terms of taste, typicality, aroma and bouquet, this sample was more preferable and eventually received a score of 9.6 points. Although there was no sharp difference between the number of aromatic substances in wine materials obtained from the Matrasa grape variety grown in different regions, some differences were still noticeable. Thus, the total amount of aromatic substances was 90.9 mg/dm3 in the wine material from the Goygol district, 88.6 mg/dm3 in Ganja and 85.6 mg/dm3 in Samukh. It turned out that in the sample of Samukh wine the content of acetates of higher alcohols was 5.7 mg/dm3, in Goygol — 5.2 mg/dm3 and, finally, in Ganja — 4.6 mg/dm3. Looking at the number of esters in both tables, it becomes clear that in the samples of wine from fatty acid esters the most common ethylhexanoate (1040-1210 mg/dm3) and ethyl-4-ONE-butanoate (1015-1430 mg/dm3).
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Tian, Yanli, Yuqiang Zhao, Jiaju Zhou, Ting Sun, Xue Luo, Chet Kurowski, Weirong Gong, Baishi Hu, and Ron R. Walcott. "Prevalence of Acidovorax citrulli in Commercial Cucurbit Seedlots During 2010–2018 in China." Plant Disease 104, no. 1 (January 2020): 255–59. http://dx.doi.org/10.1094/pdis-03-19-0666-re.

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Acidovorax citrulli is the causal agent of bacterial fruit blotch (BFB), a serious threat to cucurbit fruit and seed production worldwide. In recent years, the BFB has spread to many areas of China, mainly via the inadvertent distribution of contaminated commercial seeds. To assess the prevalence of seedborne A. citrulli in commercial watermelon and other cucurbitaceous seedlots in China, a 9-year survey was conducted between 2010 and 2018. A total of 4,839 seedlots of watermelon and other cucurbitaceous species were collected from 13 major seed production areas of China and tested by a semiselective media-based colony PCR technique for A. citrulli. Overall, A. citrulli was detected in 18.00% (871/4,839) of all cucurbitaceous seedlots. The bacterium was detected in 21.59% (38/176), 19.19% (33/172), 23.44% (214/913), 40.76% (247/606), 13.28% (85/640), 15.40% (95/617), 13.25% (73/551), 8.03% (48/598), and 6.71% (38/566) of all commercial seedlots tested from the 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, and 2018 growing seasons, respectively. Additionally, the prevalence of A. citrulli in cucurbit seedlots was determined for different seed production areas. The prevalence of A. citrulli in cucurbitaceous seedlots produced in Xinjiang, Gansu, Ningxia, Inner Mongolia, and 9 other provinces was 18.76% (582/3103), 26.34% (103/391), 21.47% (82/382), 11.11% (14/126), and 10.75% (90/837), respectively. This is the first survey for A. citrulli in commercial cucurbit seeds in China, and the relatively high prevalence suggests that commercial seeds represent a substantial source of primary inoculum that can threaten cucurbit seed and fruit production in China.
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Dinç-Zor, Şule, Bürge Aşçi, Özlem Aksu Dönmez, and Özge Hacimustafa. "Experimental Design Approach to Optimize HPLC Separation of Active Ingredients, Preservatives, and Colorants in Syrup Formulation." Journal of AOAC INTERNATIONAL 102, no. 5 (September 1, 2019): 1523–29. http://dx.doi.org/10.1093/jaoac/102.5.1523.

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Abstract Background: Preservatives and colorants in pharmaceutical products may be highly toxic, especially for sensitive individuals, when they are used in excessive amounts. In this context, sensitive and non-labor-intensive analytical methods with short analysis time for simultaneous quantification of these additive substances in drugs can meet all requirements in quality control laboratories. Objective: The aim of the study was to develop a simultaneous HPLC method for the analysis of pseudoephedrine HCl and guaifenesin, along with preservatives, methyl paraben and propyl paraben, and colorants, ponceau 4R and sunset yellow, in a syrup sample. Methods: Optimum conditions of HPLC separation were determined by Box-Behnken experimental design. Four independent variables of the separation were pH (6.0, 6.5, and 7.0) and flow rate of the mobile phase (2.0, 2.2, and 2.4 mL/min) and mobile phase ratios for the first and second gradient elutions (75, 80, and 85% for Gradient 1 and 50, 55, and 60% for Gradient 2 in terms of phosphate buffer percent, respectively). Results: The optimum conditions were found to be pH, 6.3; flow rate, 2.4 mL/min; and mobile phase ratios (phosphate buffer-acetonitrile) for Gradient 1 and 2, 85+15 (v/v) and 60+40 (v/v), respectively. Conclusions: Simultaneous analysis of all compounds was achieved by using this HPLC method with a short run time below 10 min. Highlights: This simple, rapid, and validated method is convenient and applicable for routine analysis of pharmaceutical products having similar composition without the need for any extraction step.

Частини книг з теми "660.294 85":

1

Sukhoruchkin, S. I., and Z. N. Soroko. "Neutron Resonance Parameters for Rb-85 (Rubidium)." In Supplement to Volume I/24, 1192–201. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45603-3_113.

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2

Walter Bravo Matheus, Pedro. "Sperm Physiology of South American Camelids." In Veterinary Medicine and Science. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.112876.

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The sperm physiology of South American camelids from samples collected by vaginal aspiration of the ejaculate reveals that it is perfectly sound for semen analysis. There are no significant differences between llama and alpaca semen. Volume (4 mL), motility (70%), viability (85%), concentration (32 million), normal spermatozoa (76%), abnormal heads (8%), cytoplasmic droplets (5%), abnormal tails (8.5%) and morphology is comparable to semen collected with an artificial vagina. The most salient feature is the epididymal spermatozoa’s concentration (327 million/mL). Glucose and fructose are present in uterine and oviductal fluid with less glucose concentration by 24 h after ejaculation which is concomitant with decreased spermatozoa motility. Supplemental nutrition of the male effectively improved spermatozoa concentration to 192 million spermatozoa/mL rather than 60 million in males not receiving any supplement. Altogether, practitioners and scientists could use the information in this chapter, especially spermatozoa features within the uterus and the oviduct.
3

Galastri, Leandro. "Mariátegui e a Tradução Latino-Americana do Leninismo." In Lenin: teoria e prática revolucionária, 281–98. Faculdade de Filosofia e Ciências, 2015. http://dx.doi.org/10.36311/2015.978-85-7983-680-0.p281-298.

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Barros, Mônica Kelly de Araújo, Helenilde Castro Gomes Lindoso, Francisco Raelison de Sousa Cruz, and Eduarda Gomes Bogéa. "PRÉ-NATAL ODONTOLÓGICO E ALTERAÇÕES BUCAIS EM GESTANTES DE SÃO LUÍS, MARANHÃO." In Pesquisa multidisciplinar em saúde - Volume 1. Editora Pascal LTDA, 2023. http://dx.doi.org/10.29327/5197200.1-4.

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A gestação provoca uma série de alterações no organismo da mulher, inclusive na cavidade bucal. Estima-se que, em média de 60 a 70% das gestantes apresentam manifestações bucais. Objetiva-se avaliar a realização do pré-natal odontológico e as principais alterações bucais de gestantes de São Luís, Maranhão. Trata-se de um estudo transversal, com abordagem quantitativa realizado com gestantes atendidas na rede pública e privada de saúde de São Luís, Maranhão. O instrumento de coleta de dados foi um questionário estruturado dividido em 06 blocos, em que foi utilizado para este estudo o bloco de perfil socioeconômico e obstétrico e de alterações bucais. A amostra foi composta por 100 gestantes, em que 41% estavam inclusas na faixa etária de 24 a 32 anos de idade, sendo relatado que a maioria apresentava ensino médio completo (49%). Apenas 20% realizaram consulta no pré-natal odontológico, onde 30% relataram ter ido por necessidade de restaurações e 20% por raspagem. Durante a consulta, 85% das gestantes não foram diagnosticadas com alterações bucais. A maioria das gestantes relatou ter alguma alteração bucal (85%), destacando-se o sangramento gengival (38%), dor de dente (32%) e aumento da salivação (30%). Portanto, as gestantes avaliadas tiveram baixa adesão ao pré-natal odontológico, sendo a restauração e raspagem os principais motivos para a consulta. As alterações bucais foram comumente relatadas pelas gestantes, principalmente o sangramento gengival e dor de dente. É importante demonstrar à necessidade do pré-natal odontológico, visando minimizar danos a saúde bucal e geral da gestante e do bebê. Palavras-chave: Odontologia. Manifestações bucais. Gravidez.
5

Pereira, Jose. "Management of Bone Pain." In Topics in Palliative Care, 79–116. Oxford University PressNew York, NY, 1998. http://dx.doi.org/10.1093/oso/9780195102468.003.0006.

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Abstract Pain is a common symptom in patients with cancer, occurring in 50%-85% of patients with advanced disease. Metastatic cancer invades bone in 60%-84% of cases. In several common cancers, such as breast and prostate cancers, the skeleton is the most common site of metastases. It is estimated that between 65% and 75% of patients with bone metastases present with bone pain, and the high morbidity associated with bone metastases can be protracted. Although survival varies widely among patients with metastatic bone disease, patients suffering from metastatic breast disease survive on average 34 months after detection of the first metastasis, with a range of 1-90 months. Survival with metastatic prostate cancer averages 24 months, and lung cancer patients have a poor prognosis of less than one year after bone metastases are first diagnosed. Significant advances in our knowledge of the mechanisms of bone metastases and the pathophysiology of bone pain have prompted review of traditional treatment modalities and have offered new possibilities for managing malignant bone pain more effectively. This chapter reviews current knowledge regarding the pathophysiology and treatment of malignant bone pain.
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"A.C. Petty, G.L. Daniels and P. Tippett, Vox Sang, 66, 216-224 (1994). 11. K.E. Coyne, S.E. Hall, E.S. Thompson, M.A. Arce, T. Kinoshita, T. Fujita, D.J. Anstee, W. Rosse and D.M. Lublin, J. Immun. 149. 2906-2913 (1992). 12. A.C. Petty, G.L. Daniels, D.J. Anstee and P. Tippett, Vox Sang., 65, 309-315 (1993). 13. M.J. Telen, N. Rao, E.S. Thompson and D.M. Lublin, (abs) Transfusion, 32, suppl 47S (1992). 14. G. Daniels, Vox Sang., 56, 205-211 (1989). 15. M.J. Telen, in Blood Groups:Ch/Rq. Kn/McC/Yk, Cromer. J.M. Moulds and B. Laird-Fryer, eds. American Association of Blood Banks, Bethesda MD, (1992) pp. 45-63. 16. D.M. Lublin, E.S. Thompson, A.M. Green, C. Levene and M.J. Telen, J. Clin. Invest., 87, 1945-1952 (1991). 17. D.M. Lublin, G. Mallinson, M.E. Reid, J. Poole, E.S. Thompson, B.R. Ferdman, M.J. Telen, D.J. Anstee and M.J.A. Tanner, (abs) Transfusion, 32, suppl 47S (1992). 18. P.D. Issitt, Transf. Med. Rev., 3, 1-12 (1989). 19. C. Lomas, W. Grassman, D. Ford, J. Watt, A. Gooch, J. Jones, M. Beolet, D. Stern, M. Wallace and P. Tippett, Transfusion in press. 20. P. Agre and J-P. Cartron, Blood, 78, 551-563 (1991). 21. J-P. Cartron and P. Agre, Seminars Haemat., 30, 193-208 (1993). 22. D.J. Anstee and M.J.A. Tanner, in Baillieres’s Clinical Haematology. M.J.A. Tanner and D.J. Anstee, eds. Bailliere Tindall, London (1993) pp. 401-422. 23. N.D. Avent, K. Ridgwell, W.J. Mawby, M.J.A. Tanner, D.J. Anstee and B. Kumpel, Biochem. J., 256 1043-1046 (1988). 24. C. Bloy, D. Blanchard, W. Dahr, K. Beyreuther, C. Salmon and J-P. Cartron, Blood, 72, 661-666 (1988). 25. A.M. Saboori, B.L. Smith and P. Agre, Proc. Natl. Acad. Sci. USA, 85, 4042-4045 (1988). 26. N.D. Avent, K. Ridgwell, M.J.A. Tanner and D.J. Anstee, Biochem. J., 271.821-825 (1990). 27. B. Cherif-Zahar, C. Bloy, C. Le Van Kim, D. Blanchard, P. Bailly, P. Hermand, C. Salmon, J-P. Cartron, Y. Colin, Proc. Natl. Acad. Sci. USA, 87, 6243-6247 (1990). 28. I. Mouro, Y. Colin, B. Cherif-Zahar, J-P. Cartron and C. Le Van Kim, Nature Genet., 5, 62-65 (1993). 29. K. Ridgwell, N.K. Spurr, B. Laguda, C. MacGeoch, N.D. Avent and M.J.A. Tanner, Biochem. J., 287, 223-228 (1992). 30. G. Mallinson, D.J. Anstee, N.D. Avent, K. Ridgwell, M.J.A. Tanner, G.L. Daniels, P. Tippett and A.E.G. von dem Borne, Transfusion, 30, 222-225 (1990)." In Transfusion Immunology and Medicine, 199. CRC Press, 1995. http://dx.doi.org/10.1201/9781482273441-17.

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Тези доповідей конференцій з теми "660.294 85":

1

PEERSCHKE, E. IB, and B. Ghebrehiwet. "CHARACTERIZATION OF HUMAN PLATELET ClQ BINDING SITES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643503.

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We have recently shown that platelets possess specific binding sites for Clq, a subcomponent of the first component of complement, Cl, and that occupancy of these receptor sites correlates with the previously described inhibitory effect of Clq on collagen-induced platelet aggregation. To further characterize platelet Clq receptors, washed platelets were solubilized in 5 mM sodium phosphate buffer, pH 7.5 containing 10 mM EDTA, 150 mM NaCl, 10 mM EACA, 0.5 mM PMSF, and 1% Triton X-100. After dialysis against 5 mM phosphate buffer pH 7.5 containing 10 mM EDTA, 20 mM NaCl, 10 mM EACA,0.5 mM PMSF and 0.1% Triton X-100, the lysate was passed over Clq-Sepharose-4B affinity columns. A single protein peak eluted with buffer containing 300 mM NaCl. This peak was composed of two predominant molecular weight species (85-95K, 60-66K) as assessed by SDS-polyacrylamide gel electrophoresis under non-reducing conditions. When 125-iodine surface labeled platelets were solubilized and applied to Clq-Sepharose affinity resins, the same two molecular weight species eluted and could be visualized by autoradiography following SDS-polyacrylamide gel electrophoresis. Immunoabsorption studies performed under nondenaturing conditions using protein A and the IIl/Dl monoclonal antibody, which binds specifically to platelets and inhibits platelet-Clq interactions, revealed that the 85-95K molecular weight component was preferentially absorbed, but incomplete immunoabsorption of the 60-66K molecular weight constituent was also noted. Affinity purified Clq binding sites sedimented as a single peak during 5-40% sucrose density ultracentrifugation with an S value of approximately 2.4. In addition, both the 85-95K and the 60-66K molecular weight species coeluted in the void volume of Sephadex G-100 columns. The data suggest that the 85-95K and 60-66K molecular weight species represent platelet membrane Clq binding sites, and that these sites may form weak, noncovalently associated complexes.
2

Bonnier, J. J. R. M., J. B. R. M. de Swart, and J. J. M. L. Hoffmann. "CARDIAC ENZYME RELEASE AFTER FIBRINOLYTIC THERAPY WITH INTRAVENOUS (i.v.) APSAC OR INTRACORONARY (i.e.) STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642997.

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The release of CK, CK-MB and ASAT in patients with acute myocardial infarction (AMI) was studied on the relation to reperfusion. In a randomized trial 85 patients with proven AMI entered the study. The occlusion of the infarct related vessel and reperfusion were all assessed angiographically. Fibrinolytic therapy with anisoylated plasminogen streptokinase activator complex (APSAC) i.v. or with streptokinase (SK) i.e. was started within 4 (mean 2.4) hours of the onset of symptoms. 42 were treated with a single i.v. injection over 3-5 min. of APSAC (30U) and 43 with an i.e. infusion over 60 min. of SK (250.000U). Reperfusion was assessed angiographically at 90 min. after the start of treatment. Blood samples were taken before and every 4 hours after dosing up to 24 hours. 74 patients were evaluable for this analysis. The results are:Conclusion: a statistically significant difference (p < .05)** between the reperfused and non reperfused patients could only be demonstrated for the peak value of CK in the APSAC group and of CK-MB in the SK group.*On behalf of the Dutch Invasive Reperfusion Study Group.
3

Woods, A. I., and M. A. Lazzari. "ASPIRIN FAILURE TO INHIBIT THE RELEASE OF PLASMINOGEN ACTIVATORS-INHIBITORS BY HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643126.

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Platelet-PA-Inhibitors can be released by thrombin, Col laaen( Col) and others.If they are physiologically important,inhibition of their release might facilitate thrombolysis.Intrinsic PA were tested in euclobulins (eug)of PPP and PPP+Washed platelets(WP) ,with and without aspirinf ASA) .treated with UK,SK and Col(20 atfd l2uo/ml) Results(mm2)were:euaPPP:232+78;+3×106WP/ul:217+71;+10%7ul:188+/5 +2×106MP/ul: 157+69:With UK:eugPPP:283+76;+3×l0517P/ul :234+69;+106 WP/ul :172+55;+2×l(PWP/ul :154+48; With SK:euoPPP:303+99;+3×l05WP/ul 252+65;+1067P/ul:203+68;+2×106UP/ul: 174+85;Wi th Col (20ug/ml) :eur PPP:234+97;+3×105WP/ul:160+63;+106WP/ul:141+73;+2×l06WP/ul:129+81; +2×106WP/ul+ASA: 105+31;Wi th Col uc/ml) :euaPPP:230+56;+3×l05NP/ul: 160+52;+106WP/ul:139+44;+2×106wp/ul:126+21;+2×106WP/ul+ASA:118+28. EugPPP+l/P showed lower lysis area.Col induced more decrease of lysis area in euc with WP.ASA did not modify this effect.UK and SK produced higher lysis area only in euoPPP.No difference was observed between high and low doses of Col-effect upon WP.Combined treatment of eucPPP+WP+Col, with UK and SK showed:(mm2):UK-treated eugPPP+2×106WP/ul+Col(29ug/ml):134+25;+ASA and Col(20ug/ml):115+65;+Col(2uc/ml):157+50;+ASA and Col(2uo/ml):133+49; SK-treated eupPPP+2×106WP/ul:+Col(20uo/ml):144+49;+ASA and Col(20ug/ml):128+ 60;+Co1(2ug/ml):173+66;+ASA and Col(2ug/ml):142+36.Col (20ug/ml) produced slight lower lysis area of UK and SK-treated eugPPP+WP. (p:ns). ASA did not modify this effect.Col (2uc/ml) did not produce changes in lysis area of UK and SK-treated eupPPP +WP. ASA produced slight lower lysis area(p:ns).Conclusion: high dosis of Col could release anti UK,anti SK and intrinsic PA-inhibitors from platelets;low dosis of Col could only release fntrinsic PA-inhibi tors. It suggests that anti UK and anti SK release might be triggered by stronger stimuli than intrinsic PA inhibitors.ASA could not inhibit any inhibitors release.We must consider that PA-inhibi tors could be released by different metabolic pathways other than cyclooxygenase pathway.
4

Coogan, Shane, Xiang Gao, Aaron McClung, and Wenting Sun. "Evaluation of Kinetic Mechanisms for Direct Fired Supercritical Oxy-Combustion of Natural Gas." In ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/gt2016-56658.

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Existing kinetic mechanisms for natural gas combustion are not validated under supercritical oxy-fuel conditions because of the lack of experimental validation data. Our studies show that different mechanisms have different predictions under supercritical oxy-fuel conditions. Therefore, preliminary designers may experience difficulties when selecting a mechanism for a numerical model. This paper evaluates the performance of existing chemical kinetic mechanisms and produces a reduced mechanism for preliminary designers based on the results of the evaluation. Specifically, the mechanisms considered were GRI-Mech 3.0, USC-II, San Diego 204-10-04, NUIG-I, and NUIG-III. The set of mechanisms was modeled in Cantera and compared against the literature data closest to the application range. The high pressure data set included autoignition delay time in nitrogen and argon diluents up to 85 atm and laminar flame speed in helium diluent up to 60 atm. The high carbon dioxide data set included laminar flame speed with 70% carbon dioxide diluent and the carbon monoxide species profile in an isothermal reactor with up to 95% carbon dioxide diluent. All mechanisms performed adequately against at least one dataset. Among the evaluated mechanisms, USC-II has the best overall performance and is preferred over the other mechanisms for use in the preliminary design of supercritical oxy-combustors. This is a significant distinction; USC-II predicts slower kinetics than GRI-Mech 3.0 and San Diego 2014 at the combustor conditions expected in a recompression cycle. Finally, the global pathway selection method was used to reduce the USC-II model from 111 species, 784 reactions to a 27 species, 150 reactions mechanism. Performance of the reduced mechanism was verified against USC-II over the range relevant for high inlet temperature supercritical oxy-combustion.

Звіти організацій з теми "660.294 85":

1

Smith, I. R., R. C. Paulen, and G W Hagedorn. Surficial geology, northeastern Cameron Hills, Northwest Territories, NTS 85-C/3, 4, 5, and 6. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328129.

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The northeastern Cameron Hills comprise a Cretaceous bedrock upland, rising &amp;gt;550 m above the regional boreal plains. It was inundated by the Laurentide Ice Sheet and includes much of a prominent 60 by 20 km southwest-oriented mega-scale glacial lineation field, formed in thick till. Subsequent ice flow on northeast Cameron Hills occurred north to south, and a series of lobate and ice-thrust moraines suggest glacial surging. Rotational bedrock slumps cover the eastern and northern flanks of Cameron Hills, and extensive alluvial fan deposits draining from these slopes blanket the surrounding topography. The Cameron River formed as a glacial spillway, draining southwest across the upland before turning north and draining into Tathlina Lake. An expansive raised delta and glaciolacustrine sediment cover extending up to ~295 m above sea level, south of Tathlina Lake, records impoundment of an ice-marginal lake between the northeastward-retreating Laurentide Ice Sheet and Cameron Hills.
2

Марчик, В. І. Вегетативна регуляція при виконанні легкоатлетичних вправ з бігу на короткі дистанції. Криворізький педагогічний інститут ДВНЗ "Криворізький національний університет", 2012. http://dx.doi.org/10.31812/0564/1886.

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В роботі досліджували зв’язок між показниками вегетативної нервової системи і результатами легкоатлетичних вправ з бігу на короткі дистанції в першокурсниць (29 осіб). Виявлено, що показники вегетативної нервової системи у студентів, які показали результат середній і вищий за середній при виконанні бігу на 60 м, при якому здійснюється швидкісна діяльність, в більшості досліджуваних є в межах норми: симпатичний відділ ВНС складає 80%, парасимпатичний - 90%. Показники вегетативної нервової системи у студентів, які показали результат середній і вищий за середній при виконанні бігу на 400 м, при якому здійснюється діяльність на швидкісну витривалість, в нормі симпатичний відділ ВНС складає 28% і парасимпатичний відділ ВНС - 85%. Порівняння показників відділів ВНС при виконанні бігу на різні дистанції показує готовність першокурсників виконувати швидкісну роботу і їх непідготовленість при виконанні роботи, що характеризується швидкісною витривалістю. Розгляд тестування спринтерського бігу першокурсниць на 60 м і 400 м вказує на їх низькій рівень фізичної підготовленості. Використовуючи легкоатлетичні вправи з бігу на короткі дистанції можна досягти підвищення результатів тестування і, головне, адаптації вегетативної нервової системи при виконанні роботи на швидкість і швидкісну витривалість.
3

Pavlovic, Noel, Barbara Plampin, Gayle Tonkovich, and David Hamilla. Special flora and vegetation of Indiana Dunes National Park. National Park Service, 2024. http://dx.doi.org/10.36967/2302417.

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The Indiana Dunes (comprised of 15 geographic units (see Figure 1) which include Indiana Dunes National Park, Dunes State Park, and adjacent Shirley Heinze Land Trust properties) are remarkable in the Midwest and Great Lakes region for the vascular plant diversity, with an astounding 1,212 native plant species in an area of approximately 16,000 acres! This high plant diversity is the result of the interactions among postglacial migrations, the variety of soil substrates, moisture conditions, topography, successional gradients, ?re regimes, proximity to Lake Michigan, and light levels. This richness is all the more signi?cant given the past human alterations of the landscape resulting from logging; conversion to agriculture; construction of transportation corridors, industrial sites, and residential communities; ?re suppression; land abandonment; and exotic species invasions. Despite these impacts, multiple natural areas supporting native vegetation persist. Thus, each of the 15 units of the Indiana Dunes presents up to eight subunits varying in human disturbance and consequently in ?oristic richness. Of the most signi?cant units of the park in terms of number of native species, Cowles Dunes and the Dunes State Park stand out from all the other units, with 786 and 686 native species, respectively. The next highest ranked units for numbers of native species include Keiser (630), Furnessville (574), Miller Woods (551), and Hoosier Prairie (542). The unit with lowest plant richness is Heron Rookery (220), with increasing richness in progression from Calumet Prairie (320), Hobart Prairie Grove (368), to Pinhook Bog (380). Signi?cant natural areas, retaining native vegetation composition and structure, include Cowles Bog (Cowles Dunes Unit), Howes Prairie (Cowles Dunes), Dunes Nature Preserve (Dunes State Park), Dunes Prairie Nature Preserve (Dunes State Park), Pinhook Bog, Furnessville Woods (Furnessville), Miller Woods, Inland Marsh, and Mnoke Prairie (Bailly). Wilhelm (1990) recorded a total of 1,131 native plant species for the ?ora of the Indiana Dunes. This was similar to the 1,132 species recorded by the National Park Service (2014) for the Indiana Dunes. Based on the nomenclature of Swink and Wilhelm (1994), Indiana Dunes National Park has 1,206 native plant species. If we include native varieties and hybrids, the total increases to 1,244 taxa. Based on the nomenclature used for this report?the Flora of North America (FNA 2022), and the Integrated Taxonomic Information System (ITIS 2022)?Indiana Dunes National Park houses 1,206 native vascular plant species. As of this writing (2020), the Indiana Dunes is home to 37% of the species of conservation concern in Indiana (241 out of 624 Indiana-listed species): state extirpated = 10 species, state endangered = 75, and state threatened = 100. Thus, 4% of the state-listed species in the Indiana Dunes are extirpated, 31% endangered, and 41% threatened. Watch list and rare categories have been eliminated. Twenty-nine species once documented from the Indiana Dunes may be extirpated because they have not been seen since 2001. Eleven have not been seen since 1930 and 15 since 1978. If we exclude these species, then there would be a total of 1,183 species native to the Indiana Dunes. Many of these are cryptic in their life history or diminutive, and thus are di?cult to ?nd. Looking at the growth form of native plants, <1% (nine species) are clubmosses, 3% (37) are ferns, 8% (297) are grasses and sedges, 56% (682) are forbs or herbs, 1% (16) are herbaceous vines, <1% (7) are subshrubs (woody plants of herbaceous stature), 5% (60) are shrubs, 1% (11) are lianas (woody vines), and 8% (93) are trees. Of the 332 exotic species (species introduced from outside North America), 65% (219 species) are forbs such as garlic mustard (Alliaria petiolata), 15% (50 species) are graminoids such as phragmites (Phragmites australis ssp. australis), 2% (seven species) are vines such as ?eld bindweed (Convulvulus arvensis), <1% (two species) are subshrubs such as Japanese pachysandra (Pachysandra terminalis), 8% (28 species) are shrubs such as Asian bush honeysuckle (Lonicera spp.), 1% (three species) are lianas such as oriental bittersweet (Celastrus orbiculatus), and 8% (23 species) are trees such as tree of heaven (Ailanthus altissimus). Of the 85 adventive species, native species that have invaded from elsewhere in North America, 14% (11 species) are graminoids such as broom sedge (Andropogon virginicus), 57% (48 species) are forbs such as fall phlox (Phlox paniculata), 5% (six species) are shrubs such as Carolina allspice (Calycanthus floridus), 3% (two species) are subshrubs such as holly leaved barberry (Berberis repens), 1% (one species) is a liana (trumpet creeper (Campsis radicans), 3% two species) are herbaceous vines such as tall morning glory (Ipomoea purpurea), and 17% (15 species) are trees such as American holly (Ilex opaca). A total of 436 species were found to be ?special? based on political rankings (federal and state-listed threatened and endangered species), species with charismatic ?owers, and those that are locally rare.
4

Peroni, Fabiana da Mota, Larissa C. Gruchovski Veríssimo, Leonardo Goes Shibata, and Natalia Aranco. Envejecimiento y atención a la dependencia en Brasil. Inter-American Development Bank, March 2023. http://dx.doi.org/10.18235/0004792.

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Al igual que otros países de América Latina y el Caribe, Brasil experimenta un rápido proceso de envejecimiento poblacional. La transición demográfica, sumada a las mejores condiciones de vida de la población en las últimas décadas, ha garantizado un aumento sin precedentes en la expectativa de vida de los brasileños. Se espera que la población mayor de 65 años pase del 13% que registra en la actualidad a 22% en 2050. Este envejecimiento de la población trae consigo desafíos, uno de los cuales es cómo satisfacer la creciente demanda de servicios de atención a la dependencia en un contexto que ve reducirse las redes de cuidado tradicional. En efecto, el 10,5% de las personas de 65 años y más se encuentra en situación de dependencia funcional, y el porcentaje llega a 29% entre los mayores de 85. En términos absolutos esto significa más de 2 millones de personas mayores de 65 años con dificultades para realizar actividades básicas de la vida diaria. Este número puede llegar a más de 6 millones de personas hasta 2050. Este reporte presenta un panorama del envejecimiento de la población brasileña poniendo el foco en su condición de dependencia funcional y analiza, asimismo, el papel del Estado en la satisfacción de la demanda de cuidados de largo plazo, así como la oferta de servicios, públicos y privados, disponibles en el país. Debido al modelo organizativo federalista de Brasil, donde municipios y estados tienen autonomía para adherirse a programas y políticas del gobierno federal, las acciones no son homogéneas en todo el territorio. Con el propósito de presentar un análisis que muestre la heterogeneidad de la realidad brasileña, se optó por tomar como ejemplos un estudio de caso del estado de Sao Paulo y de tres de sus municipios (So Paulo, Caraguatatuba y Taguaí), con tamaños poblacionales diferentes. El estudio revela la existencia de importantes espacios que se beneficiarían de mejoras, tanto en lo concerniente a la cobertura como a la calidad de los servicios de atención a la dependencia dirigidos a las personas mayores. A pesar de algunos esfuerzos a nivel local, el país no cuenta aún con un sistema de atención integrado a nivel nacional que tenga respaldo legal e institucional. Los servicios de atención a la dependencia para personas mayores se enmarcan, en su mayoría, en el Sistema único de Asistencia Social (SUAS), con algunos otros que se ofrecen en el contexto del Sistema único de Salud (SUS). Predominan los cuidados de carácter residencial, con una participación mayoritaria del sector privado en la provisión de servicios. En efecto, solo el 2% de las aproximadamente 7 mil instituciones de larga estadía que existen en el país son públicas. Estas atienden a personas mayores de 60 años, con diferentes grados de dependencia, que no pueden vivir con su familia. Los centros de día también son parte importante de la oferta pública de servicios para la población mayor dependiente, con 1.640 centros registrados en 2018 (la mayoría en la región Sudeste). Estos centros atienden a casi 14.500 personas en situación de dependencia o discapacidad. Por último, se destaca la falta de servicios de cuidados en el hogar. El Programa Mejor en Casa del SUS fue diseñado para atender a las personas mayores que no pueden salir de su hogar, pero su enfoque es exclusivamente sanitario, y no ofrece apoyo en la realización de las actividades diarias u otro tipo de apoyo social Esta nota técnica es publicada conjuntamente por el Banco Interamericano de Desarrollo (BID) y el Programa de la Unión Europea EUROsociAL, como parte de una serie de estudios sobre envejecimiento y atención a personas en situación de dependencia, que se encuentran disponibles en la página web "Panorama de Envejecimiento y Atención a la Dependencia".

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