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Статті в журналах з теми "658.1/1"
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Jana, J. C., S. Guha, and R. Chatterjee. "Effect of planting geometry and nitrogen levels on crop growth, fruit yield and quality in okra grown during early winter in terai zone of West Bengal." Journal of Horticultural Sciences 5, no. 1 (June 30, 2010): 30–33. http://dx.doi.org/10.24154/jhs.v5i1.488.
Повний текст джерелаАнотація:
A field-experiment was conducted in early winter of 2006 and 2007 under sub-Himalayan terai agroclimatic region of West Bengal to evaluate comparative effect of planting geometry and nitrogen levels on growth, yield and fruit quality in okra variety Arka Anamika. The experiment was laid out in factorial randomized block design and replicated thrice, with four levels of nitrogen, viz., 50 kg, 100 kg, 150 kg and 200 kg ha-1 and four different spacings viz., 30 cm x 15 cm, 30 cm x 30 cm, 45 cm x 30 cm and 60 cm x 30 cm. Among different treatment combinations, application of 150 kg N ha-1 and 45 cm x 30 cm spacing recorded the highest number of fruits plant-1 (13.7), individual fruit weight (18.5 gm), fruit yield plant-1 (195.0 g), fruit yield ha-1 (12.2 t) and Vitamin C content in fruits (25.3 mg /100 g). Fertilization with 200 kg N ha-1 and 45 cm x 30 cm spacing recorded the highest value for nitrate content in fruits (658.1 mg kg-1). The study amply revealed scope for growing okra crop profitably during early winter season of mild, cool temperature by adopting nitrogen levels of 150 kg ha-1 with plant spacing of 45 cm x 30 cm in the terai agro-climatic region of West Bengal.
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Ravandi, Farhad, Jorgensen L. Jeffrey, Deborah A. Thomas, Susan O'Brien, Elias Jabbour, Gautam Borthakur, Rebecca Garris, et al. "Minimal Residual Disease (MRD) Assessed By Multi-Parameter Flow Cytometry (MFC) Is Highly Predictive of Outcome in Adult Patients with Acute Lymphoblastic Leukemia (ALL)." Blood 124, no. 21 (December 6, 2014): 1079. http://dx.doi.org/10.1182/blood.v124.21.1079.1079.
Повний текст джерелаАнотація:
Abstract Purpose - Predicting outcome in patients with ALL has been traditionally based on pre-treatment characteristics such as age, white blood cell count (WBC) and cytogenetics. Minimal residual disease is a surrogate to the complex interaction of disease biology and therapy and its role in assigning risk is well-established. Many prior studies in patients with ALL have used molecular markers of MRD with few studies evaluating the role of multi-parameter flow cytometry (MFC) in the adult population. We investigated the predictive value of MRD assessed by MFC among 340 patients with ALL treated between March 2004 and March 2014 using regimens including the hyperCVAD backbone. Methods - Among 340 patients with B-ALL treated in this period 323 (95%) achieved complete remission (CR) or CR without platelet recovery (CRp) and were included in this study. Median age was 52 (Range, 15-84). Median WBC was 9.35 x109/L (Range, 0.4-658.1 x109/L). Cytogenetics were normal in 62 (18%), Philadelphia+ in 146 (43%), 11q23/rearranged MLL in 14 (4%), aneuploid in 45 (13%), hyperdiploid in 29 (9%), hypodiploid in 13 (4%), insufficient metaphases/ not done in 31 (9%). MRD by MFC was assessed with a sensitivity of 0.01%, using a 15-marker, 4-color panel in the first half of the study and subsequently a 6-color panel. Bone marrow specimens for MRD assessment were obtained at the time of achievement of CR and at approximately 3 month intervals thereafter. Results - 260 patients had available samples at CR and 166 (64%) became MRD negative. Achieving MRD negative status at CR was associated with a statistically significant improvement in disease-free survival (P =0.004) and overall survival (P=0.03). 215 patients were evaluated for MRD at approximately 3 months and 201 (93%) became negative. Achieving MRD negative status at approximately 3 months was also associated with a statistically significant improvement in DFS (P=0.002) and OS (P=0.003). 166 patients were evaluated for MRD at approximately 6 months and 160 (96%) became negative. Achieving MRD negative status at approximately 6 months was also associated with a statistically significant improvement in DFS (P<0.0001) and OS (P<0.0001). Figure below demonstrates the DFS and OS by MRD status at CR (Figure 1a and 1b), at 3 months (Figure 2a and 2b), and at 6 months (Figure 3a and 3b) with patients censored at the time of undergoing an allogeneic stem cell transplant or last follow-up. On multivariate analysis including age, WBC at presentation, cytogenetics (standard vs. high risk), and MRD status at CR, 3 months and 6 months, achieving an MRD negative status at CR was an independent predictor of DFS (P<0.05). Conclusion – Achievement of an MRD negative state assessed by MFC is an important predictor of DFS and OS in patients with ALL Figure 1 Figure 1. Figure 2 Figure 2. Figure 3 Figure 3. Disclosures No relevant conflicts of interest to declare.
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Xia, Daocheng, and Feng Feng. "Crystal structure of 1-methyl-5-(4-(1-methyl-1H-tetrazol-5-ylthio) butylthio)-1H-tetrazole, C8H14N8S2." Zeitschrift für Kristallographie - New Crystal Structures 228, no. 1 (March 1, 2013): 11–12. http://dx.doi.org/10.1524/ncrs.2013.0007.
Повний текст джерела
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Ravandi, Farhad, Susan O'Brien, Rebecca Garris, Stefan H. Faderl, Deborah A. Thomas, Jan A. Burger, Alessandra Ferrajoli, Elias Jabbour, Jorge E. Cortes, and Hagop M. Kantarjian. "Final Report Of Single-Center Study Of Chemotherapy Plus Dasatinib For The Initial Treatment Of Patients With Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia." Blood 122, no. 21 (November 15, 2013): 3914. http://dx.doi.org/10.1182/blood.v122.21.3914.3914.
Повний текст джерелаАнотація:
Abstract Background The dual Src and Abl inhibitor dasatinib has significant in vitro kinase inhibition against wild-type and mutant BCR-ABL, and significant clinical activity in patients with imatinib-resistant lymphoid blast phase CML (CML-LB) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). Aim To determine the long-term efficacy of the combination of the hyperCVAD regimen with dasatinib for treating patients with Ph+ ALL. Methods In this phase II trial, patients with newly diagnosed Ph+ ALL received dasatinib 50 mg po bid (or 100 mg daily) for the first 14 days of each of 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate (induction/consolidation cycles). After 42 patients, the protocol was amended to give dasatinib 100 mg daily in the first 14 days of the first cycle and then 70 mg daily continuously from the second cycle. Patients in complete remission (CR) continued to receive maintenance dasatinib 50 mg po bid (or 100 mg daily) and vincristine and prednisone monthly for 2 years followed by dasatinib indefinitely. Patients eligible for allogeneic stem cell transplant proceeded to it in first CR. Results 63 patients with untreated Ph+ ALL and 9 patients with 1 or 2 prior cycles of chemotherapy (before Ph+/BCR-ABL+ status was known) have been enrolled in the study from September 2006 to March 2012. Patients have received a median of 6 cycles (range 1-8) of induction/consolidation. Median age is 55 years (range 21 – 80); 46 patients were older than 50 years, Median WBC at diagnosis was 12 x 109/L (range, 0.4 - 658.1 x 109/L). Ten patients had CNS involvement at presentation. All patients are evaluable for assessment of response to induction; 69 (96%) achieved CR after first cycle or were CR at start. 3 patients died before response assessment from infections. 57 of 69 (83%) evaluable patients achieved cytogenetic (CG) CR after 1 cycle; 5 had a major CG response (4 had 5% and one had 15% Ph+), 2 had insufficient metaphases, and 5 are unknown (no CG exam on day 21 marrow). To date, 45 patients (65%) have achieved complete molecular remission (CMR) and another 19 (28%) have achieved a major (but not complete) molecular response (MMR) at a median of 4 weeks from initiation of treatment (range, 2 – 38 weeks). Minimal residual disease assessment by flow cytometry is negative in 65 (94 %) patients at a median of 3 weeks (range, 2-37 weeks). The median time to neutrophil and platelet recovery for cycle 1 is 18 and 22 days and for subsequent cycles is 15 and 20 days. Grade 3 and 4 adverse events have included bleeding (GI, GU, soft tissue and subdural hematomas), pleural effusions, pericardial effusions, reversible rise in creatinine, deep vein thromboses, pulmonary emboli, as well as diarrhea, infections, hypophosphatemia, hypokalemia, hypocalcemia, hyperglycemia, and elevated transaminases. With a median follow up of 48 months in the surviving patients (range 16.5 - 81.5), 36 patients (50%) are alive and 31 (43%) are in CR. Twelve patients have undergone an allogeneic stem cell transplant. Thirty six patients have died [3 at induction, 16 after relapse, 7 post stem cell transplant performed in CR1, and 10 in CR (6 from infections, 1 from unrelated cardiac event, 1 from unrelated cancer, and 2 from an unknown cause)]. The median disease free survival is 31 months (range, 0.3 to 81) and the median overall survival is 44 months (range, 0.2 to 82). Twenty-one patients have relapsed with a median response duration of 16 months (range, 5 - 62) and 16 of them have died. In 6 patients morphological relapse was preceded by flow and molecular relapse. Six relapsed patients had ABL mutations (4 T315I, 1 F359V, and 1 V299L). Conclusion Combination of chemotherapy with dasatinib is effective in achieving long term remissions in patients with newly diagnosed Ph+ ALL. Disclosures: Ravandi: Bristol Myers Squibb: Honoraria, Research Funding. Off Label Use: Use of dasatinib for the frontline therapy of Ph+ ALL. O'Brien:Pharmacyclics: Research Funding. Jabbour:Bristol Myers Squibb: Consultancy, Honoraria. Cortes:Bristol Myers Squibb: Research Funding. Kantarjian:Bristol Myers Squibb: Research Funding.
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Merzweiler, Kurt, and Hans-Jörg Kersten. "Notizen: Darstellung und Kristallstruktur von [{(CO)5WPhP}2S2] / Synthesis and Crystal Structure of [{(CO)5WPhP}2S2]." Zeitschrift für Naturforschung B 48, no. 4 (April 1, 1993): 541–44. http://dx.doi.org/10.1515/znb-1993-0422.
Повний текст джерелаАнотація:
The reaction of [{(CO)5W}PhPCl2] with S(SiMe3)2 leads to the formation of [{(CO)5WPhP}2S2] (1). 1 crystallizes in the space group P21/n. The lattice constants (at 298 K) are: a = 658.9(3), b = 2287.6(11), c = 1905.5(9) pm, β = 94.53(3)°. According to the crystal structure determination 1 contains a four-membered P2S2 ring which is coordinated to two {(CO)5W} units.
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Zhang, Dawei, Yanrong Ren, Zhenhua Jin, Yonghua Duan, Mingli Xu, and Jie Yu. "Facile Synthesis of PtPd Network Structure Nanochains Supported on Multi-Walled Carbon Nanotubes for Methanol Oxidation." Metals 12, no. 11 (November 8, 2022): 1911. http://dx.doi.org/10.3390/met12111911.
Повний текст джерелаАнотація:
In this paper, a PtPd NC catalyst with a network structure of nanochains was prepared with KBr as a structure-directing agent, NaBH4 as a reducing agent, and modified multi-walled carbon nanotubes (MWCNTs) as a support. The experimental results show that the structure-directing agent KBr helps to form a particular type of nanochain with a network topology. PtPd NCs with various ratios (Pt:Pd = 2:1, 1:1, 1:2) have respective diameters of 30 nm, 35 nm, and 23 nm. With numerous structural flaws at the junctions, the nanochains’ distinctive network structure increases the number of active sites on the PtPd nanocenter surface. Electrochemical characterization results show that the current density of the PtPd NCs is about 658.5 mA mg−1, 1.5-times that of the Pt/C catalyst and 3.9-times that of the commercial Pd/C catalyst. Furthermore, it has better electrocatalytic stability for methanol oxidation than Pd/C and Pt/C catalysts.
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Lee, M. R., M. Quartern, and S. Jaulmes. "New Crystal Data for Seven Molybdates MIIUMo4O16 (MII = Mg,Mn,Cd,Ca,Hg,Sr,Pb)." Powder Diffraction 3, no. 2 (June 1988): 106–9. http://dx.doi.org/10.1017/s0885715600013361.
Повний текст джерелаАнотація:
AbstractSeven isotopic molybdates MIIUMo4O16 have been synthesized by solid state reaction with MII = Mg, Mn, Cd, Ca, Hg, Sr, Pb. Single crystals of CaUMo4O16 were obtained. Previously reported as triclinic, this compound is monoclinic, space group P2/n. Unit-cell parameters for the seven compounds are:MgUMo4O16: a = 11.393(2), b = 6.505(1), c = 7.918(2) Å, β = 89.81(3)°, V = 586.8(5) Å3, Z = 2, Dx = 5.12 Mg m−3;MnUMo4O16: a = 11.413(2), b = 6.555(1), c = 8.023(1) Å, β = 89.86(2)°, V = 600.2(4)Å3, Z = 2, Dx = 5.18 Mg m−3;CdUMo4O16: a = 11.427(2), b = 6.607(1), c = 8.144(2) Å3, β = 90.40(2)°, V = 614.8(5)Å3, Z = 2, Dx = 5.37 Mg m−3;CaUMo4O16: a = 11.443(3), b = 6.653(2), c = 8.239(2)Å, β = 90.51(3)°, V = 627.2(6)Å3, Z = 2, Dm = 4.83(5), Dx = 4.88 Mg m−3;HgUMo4O16: a = 11.439(3), b = 6.643(1), c = 8.257(2)Å, β = 90.53(3)°, V = 627.4(6)Å3, Z = 2, Dx = 5.73 Mg m−3;SrUMo4O16: 11.465(3), b = 6.768(2), c = 8.492(2) Å, β = 90.86(3)°, V = 658.8(6)Å3, Z = 2, Dx = 4.88 Mg m−3;PbUMo4O16: a = 11.470(4), b = 6.813(2), c = 8.557(2)Å, β = 90.88(4)°, V = 668.7(8)Å3, Dx = 5.41 Mg m−3;Powder diffraction data for each phase are reported.
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Iijima, Kei, Kazutaka Kamiya, Yoshihiko Iida, and Nobuyuki Shoji. "Comparison of Laser Iridotomy and Lensectomy Outcomes for Acute Primary Angle Closure." Journal of Ophthalmology 2022 (May 30, 2022): 1–5. http://dx.doi.org/10.1155/2022/6959479.
Повний текст джерелаАнотація:
Purpose. To compare the clinical outcomes of the different treatments for acute primary angle closure (APAC). Methods. We retrospectively reviewed the clinical charts of 87 eyes of 87 patients undergoing treatment for APAC. We investigated the best spectacle-corrected visual acuity (BSCVA), intraocular pressure (IOP), corneal endothelial cell density (ECD), and secondary interventions after each treatment. Results. The pretreated IOP was 56.4 ± 9.0 mmHg. As the first treatment for APAC, all eyes underwent topical 2% pilocarpine and systemic mannitol administration. Subsequent laser iridotomy (LI) and lensectomy were necessary in 29 eyes (33%) and 35 eyes (40%), respectively. Bullous keratopathy developed in 1 eye (1%), and following glaucoma surgery was required in 7 eyes (8%). The BSCVA at the final follow-up was 0.16 ± 0.53 and 0.01 ± 0.20 logMAR (Mann–Whitney U test, p = 0.149 ), the IOP was 12.8 ± 2.6, and 12.6 ± 2.9 mmHg ( p = 0.860 ), and the ECD was 2295.9 ± 658.2 and 2244.1 ± 622.0 cells/mm2 ( p = 0.735 ) in the LI and lensectomy groups, respectively. Conclusions. Approximately 26% of eyes with APAC were resolved after the initial medical treatment, and subsequent surgical treatments, such as LI and lensectomy, were required in 33% and 40% of eyes, respectively. We found no significant differences in the BSCVA, the IOP, or the ECD among LI and lensectomy treatment groups.
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Rama, Mirvete, Mirela Miraci, Idriz Balla, Ela Petrela, Ledjan Malaj, and Anjeza Koleci. "Cost-Effectiveness of Thrombolytic Therapy, Compared with Anticoagulants Therapy in the Treatment of Acute Myocardial Infarction in Albania." Open Access Macedonian Journal of Medical Sciences 3, no. 2 (May 28, 2015): 341–44. http://dx.doi.org/10.3889/oamjms.2015.060.
Повний текст джерелаАнотація:
AIM: The study aim is to evaluate the cost-effectiveness of thrombolytic treatment in acute MI comparing with anticoagulants therapy and between each other thrombolytic (SK, r-Pa).MATERIAL AND METHODS: We used a prospective registry of all patients admitted for acute myocardial infarction in intensive care units in Tirana. The average drugs cost was calculated for the hospitalization period in Albanian money (ALL). Survival and life quality were estimated by phone contact 1 year after acute MI.RESULTS: Anticoagulant group cost is 23865.3 ALL (170.5€), SK group cost is 54148.63 ALL (386.7€), r-Pa group has a cost of 92184.90 ALL (658.5€). In the group treated with SK the hospital survival is 100%, while in the control group 88.8%. Reteplase group has a lower period of stay in hospital than SK group 13.04 days vs. 17.97 days, mean age in group treated with r-Pa is 64.29 ± 10.03 approximate with anticoagulant group mean age 64.17 ± 11.08; differ significantly with SK group mean age 56.75 ± 10.04. Survival after 1 year was 96.4% for r-Pa and 96.9% SK.CONCLUSIONS: SK and r-Pa are successful thrombolytics with high effectiveness. It is gained a higher survival with the thrombolytic treatments. Reteplase is well tolerated in older patients than SK, is easier to apply than Streptokinase, but has higher cost.
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Andrade, Maria Gabriela de Oliveira, Sebastião Ferreira de Lima, Eduardo Pradi Vendruscolo, Jorgiani de Ávila, Jordana Dias Martins, and Ana Paula Leite de Lima. "Nitrogen and potassium fertilization affects banana production." Research, Society and Development 9, no. 7 (May 9, 2020): e227973753. http://dx.doi.org/10.33448/rsd-v9i7.3753.
Повний текст джерелаАнотація:
Banana crop presents rapid growth and high fruit production, demanding intense fertilization, with nitrogen and potassium being the most outstanding nutrients. However, national productivity is still low, indicating the need for studies to improve the performance of this fruit. Thus, the objective of this work was to evaluate the productivity and fruit characteristics of Thap Maeo banana, second cycle, under nitrogen and potassium fertilization. Plants of the cultivar Thap Maeo were used in spacing of 2.5 m x 2.5 m. The experimental design was in randomized blocks in a 2 x 4 factorial scheme with three replicates. The combination of presence (400 kg ha-1) or absence of nitrogen and four doses of potassium (0, 300, 600 and 900 kg of K2O ha-1) composed the treatments. It was observed that the application of K2O at the best doses gave gains of 8.5; 5.9; 16.3; 50.2; 20.0 and 27.6%, respectively, for the hands per bunch, fruits per hand, fruits per bunch, fruit diameter and fruit length, and fruit yield, when compared to the control. It was concluded that the use of nitrogen in association with K2O influences in isolation the number of hands per bunch and fruits per bunch, increasing their values. The variables hands per bunch, fruits per hand, fruits per bunch, fruit diameter, length and yield were benefited by the application of K2O, and the best doses were in the range of 502.7 to 658.0 kg ha-1.
Дисертації з теми "658.1/1"
1
Popova, Irina. "Start-up incubation: a rite of passage of entrepreneurs and their social ventures." Thesis, Anglia Ruskin University, 2016. https://arro.anglia.ac.uk/id/eprint/702183/1/Popova_2016.pdf.
Повний текст джерелаАнотація:
This dissertation presents a socio-anthropological investigation of social venture incubation: a process of providing enterprise support aimed at creating social change. Most previous research on incubation has focused on venture development and growth, and the efficacy of incubation in terms of the economic contribution firms make. In this study I contribute by investigating the process of incubation, conceptualising it as a rite of passage of both the entrepreneur and the venture.
I conducted an ethnographic study following the rites of passage of one cohort of social entrepreneurs and their ventures - from selection to incorporation into the business world. The insider perspective provided access to both the organisers and designers of the process as well as the entrepreneurs over a period of 15 months. I thematically analysed my data with NVivo using an a priori and emergent coding system.
The key finding of the study was the dual nature of the incubatee, the liminal entity in this rite of passage. As opposed to most incubation studies, I found that the process was as much a transition of the ventures as it was for the entrepreneurs. The rite of passage framework enabled me to identify the transition to becoming a social entrepreneur. In addition the study contributes theoretically showing the importance of social exchanges in participants’ relationships as well as the variety of different engagement patterns in the entrepreneurial rite of passage. Engagement also influences incubation outcomes and evaluation.
The value of the research findings for managers of such initiatives include designing relevant evaluation systems and strengthening the case for social incubation. Policy makers and funders of such initiatives thus need to take into account the different outcomes and impact of the programmes when allocating resources. The dual nature of the incubatee and impact on the incubatee should thus be taken into account when setting expected outcomes.
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Thorez, Eric. "CDS and the forecasting of bank default." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLED073/document.
Повний текст джерелаАнотація:
A partir d’une analyse du défaut des banques et de la régulation au travers des notations de crédits (et des agences de notation), des modèles portant sur les CDS, de Bâle III et du capital insurance, nous trouvons que les spécificités des CDS en font un bon candidat pour prévoir (et idéalement empêcher) les défauts potentiels des banques. En effet, grâce aux propriétés (financières et économiques) des CDS, ainsi qu’aux résultats d’études empiriques, nous montrons qu’ils reflètent correctement le comportement des risques des banques et qu’ils ont capté les changements informationnels plus rapidement que les notations de crédits qui sont restées relativement constantes durant 2007 et 2008.Ainsi, en utilisant un déclencheur ad hoc basé sur les CDS et l’action appropriée si le déclencheur venait à s’activer, nous pourrions empêcher le défaut d’une banque. Et la compréhension du mécanisme afférent au capital contingent est d’un grand intérêt pour atteindre cet objectif qui optimise le monitoring mis en oeuvre par les banques et les régulateursBased on an analysis of the default of the banks and regulation through credit ratings (and rating agencies), CDS models, Basel III, bail-In and capital insurance, we find that the characteristics of CDS make them a good candidate to forecast (and ideally prevent) the potential defaults of the banks. Indeed, thanks to the economics of CDS and results of empirical studies, we show that they are a good proxy of bank risks and that they did capture information changes more quickly than the credit ratings which remained relatively constant during 2007 and 2008.So, using a specific trigger based on CDS and the appropriate action, should the trigger be activated, we could prevent the default of a bank. And the understanding of contingent capital mechanism is of great interest to reach this objective which optimizes the monitoring implemented by banks as well as regulators
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Yousef, I. "Mergers and acquisitions : implications for acquirers' shareholder wealth and risk." Thesis, Coventry University, 2016. http://curve.coventry.ac.uk/open/items/f9909fcd-783b-4ee5-983a-52e16c2dff8c/1.
Повний текст джерелаАнотація:
This study analyses the impact of M&As on acquiring company shareholder wealth and market risk through empirical evidence based on event study methods and cross-sectional regressions. The hypotheses investigated relate to the relevance of target status, method of payment, acquirers‘ bidding experience, and diversification motives. The evidence is based on a comprehensive sample of M&A transactions comprising 46,758 initial bids announced in 180 countries over the period 1977-2012, covering 88 industries. The study also investigates the relevance of deal and firm-specific factors affecting the likelihood of the success or failure of a deal once announced. The results of the event study indicate that acquirers‘ abnormal returns are not influenced by uncertainty about whether the announced deals will succeed or fail, which is consistent with the efficient market hypothesis. The event study evidence also confirms that acquirers‘ gains are most significant in cross-border M&As with acquirers located in developed countries and targets in developing countries. Further evidence from cross-sectional regressions confirms that cross-border and cross-industry diversification yields significant announcement gains for acquirers, although in comparison with domestic and focussed deals, such deals carry a greater risk of failure. Diversification has no significant impact on acquirers‘ market or systematic risk. In addition, the evidence with regard to the impact of target status and method of payment suggests that acquirers‘ gains are most significant in stock payment deals involving private or subsidiary targets, while stock payment deals involving publicly-listed targets yield lower returns. In general, cash payment for acquisitions serves to reduce the negative impact of acquiring public targets, while stock payment enhances the positive impact of acquiring private or subsidiary targets. Correspondingly, acquirers‘ market increases with the acquisition of non-public targets, while using cash payment reduces this risk. The overall findings in this regard are robust across various samples and are generally associated with the existence of information asymmetry between acquirers and targets. Finally, the findings reveal that acquirers‘ prior experience of bidding in M&A deals is associated with significantly lower shareholder returns for acquirers, and this also increases their risk. This finding, however, is specific to serial acquirers and generally supports the hubris motive.
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Liao, Yongxin. "Annotations sémantiques pour l'intéropérabilité des systèmes dans un environnement PLM." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0135/document.
Повний текст джерелаАнотація:
Dans l'industrie l'approche de gestion du cycle de vie du produit (PLM) a été considérée comme une solution essentielle pour améliorer la compétitivité des produits. Elle vise à fournir une plate-forme commune qui rassemble les différents systèmes de l'entreprise à chaque étape du cycle de vie du produit dans ou à travers les entreprises. Bien que les principaux éditeurs de logiciels fassent des efforts pour créer des outils offrant un ensemble complet et intégré de systèmes, la plupart d' entre eux n'intègrent pas l'ensemble des systèmes. Enfin, ils ne fournissent pas une intégration cohérente de l'ensemble du système d'information. Il en résulte une sorte de « tour de Babel », où chaque application est considérée comme une île au milieu de l'océan de l'information, gérée par de nombreuses parties prenantes dans une entreprise, ou même dans un réseau d'entreprises. L'hétérogénéité des parties prenantes augmente le problème d'interopérabilité. L'objectif de cette thèse est de traiter la question de l'interopérabilité sémantique, en proposant une méthode d'annotation sémantique formelle pour favoriser la compréhension mutuelle de la sémantique de l'information partagée et échangée dans un environnement PLMIn manufacturing enterprises the Product Lifecycle Management (PLM) approach has been considered as an essential solution for improving the product competitive ability. It aims at providing a shared platform that brings together different enterprise systems at each stage of a product life cycle in or across enterprises. Although the main software companies are making efforts to create tools for offering a complete and integrated set of systems, most of them have not implemented all of the systems. Finally, they do not provide a coherent integration of the entire information system. This results in a kind of "tower of Babel", where each application is considered as an island in the middle of the ocean of information, managed by many stakeholders in an enterprise, or even in a network of enterprises. The different peculiarities of those stakeholders are then over increasing the issue of interoperability. The objective of this thesis is to deal with the issue of semantic interoperability, by proposing a formal semantic annotation method to support the mutual understanding of the semantics inside the shared and exchanged information in a PLM environment
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Liao, Yongxin. "Annotations sémantiques pour l'intéropérabilité des systèmes dans un environnement PLM." Electronic Thesis or Diss., Université de Lorraine, 2013. http://www.theses.fr/2013LORR0135.
Повний текст джерелаАнотація:
Dans l'industrie l'approche de gestion du cycle de vie du produit (PLM) a été considérée comme une solution essentielle pour améliorer la compétitivité des produits. Elle vise à fournir une plate-forme commune qui rassemble les différents systèmes de l'entreprise à chaque étape du cycle de vie du produit dans ou à travers les entreprises. Bien que les principaux éditeurs de logiciels fassent des efforts pour créer des outils offrant un ensemble complet et intégré de systèmes, la plupart d' entre eux n'intègrent pas l'ensemble des systèmes. Enfin, ils ne fournissent pas une intégration cohérente de l'ensemble du système d'information. Il en résulte une sorte de « tour de Babel », où chaque application est considérée comme une île au milieu de l'océan de l'information, gérée par de nombreuses parties prenantes dans une entreprise, ou même dans un réseau d'entreprises. L'hétérogénéité des parties prenantes augmente le problème d'interopérabilité. L'objectif de cette thèse est de traiter la question de l'interopérabilité sémantique, en proposant une méthode d'annotation sémantique formelle pour favoriser la compréhension mutuelle de la sémantique de l'information partagée et échangée dans un environnement PLMIn manufacturing enterprises the Product Lifecycle Management (PLM) approach has been considered as an essential solution for improving the product competitive ability. It aims at providing a shared platform that brings together different enterprise systems at each stage of a product life cycle in or across enterprises. Although the main software companies are making efforts to create tools for offering a complete and integrated set of systems, most of them have not implemented all of the systems. Finally, they do not provide a coherent integration of the entire information system. This results in a kind of "tower of Babel", where each application is considered as an island in the middle of the ocean of information, managed by many stakeholders in an enterprise, or even in a network of enterprises. The different peculiarities of those stakeholders are then over increasing the issue of interoperability. The objective of this thesis is to deal with the issue of semantic interoperability, by proposing a formal semantic annotation method to support the mutual understanding of the semantics inside the shared and exchanged information in a PLM environment
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Ferreira, João Bruno Afonso Gomes. "Implementação de linhas de produção com um pensamento e técnicas Lean." Master's thesis, 2013. http://hdl.handle.net/1822/27296.
Повний текст джерелаАнотація:
Dissertação de mestrado integrado em Engenharia e Gestão IndustrialLean Thinking possui como principais objetivos a melhoria das empresas ao nível de aumento de produtividade, melhoria da qualidade dos produtos, redução de stocks, redução de lead time, bem como a eliminação de todo e qualquer tipo de desperdício numa empresa. Inúmeras técnicas são depreendidas ao longo da escrita do seguinte projeto tais como Just In Time, Value Stream Mapping, Kaizen, trabalho normalizado, organização do posto de trabalho, técnicas de gestão visual entre outras. O projeto foi desenvolvido numa empresa de vestuário muito tradicional, que se depara com os problemas mais comuns neste setor. Referimo-nos à baixa produtividade, lead times excessivamente longos, retrabalho, uma produção orientado ao produto etc. O objetivo era implementação de linhas de produção com um pensamento e técnicas Lean, mas com o decorrer do estágio - a implementação de linhas não foi possível - sendo simulado no software Arena a sua hipotética implementação de modo a corroborar a mudança da produção. Foram também aplicadas técnicas Lean em várias secções da empresa em estudo de modo a melhorar o estado atual. Numa primeira fase foi desenvolvida uma pesquisa exaustiva sobre Lean Thinking, começando com a criação da filosofia, desenvolvimento das técnicas e ferramentas. Após análise e compreensão de todos os conceitos para aplicação no ambiente industrial em que nos inserimos, foi elaborada uma análise meticulosa e critica ao sistema produtivo da empresa, com especial incidência na secção de costura. Nesta análise foram identificados todos os problemas com os quais ali nos pudéssemos deparar. Uma vez feita análise, procedeu-se à implementação das propostas de melhorias, entre elas uma mudança de layout atual, gestão visual, programa 5S, práticas de gestão de qualidade e produção em linha. Depois de implementadas algumas ferramentas foram comparados os resultados obtidos e deparamo-nos com um aumento de produção – caso as linhas fossem implementadas – de 47 %, com redução do WIP em 64,7 % entre outras melhorias igualmente significativas. Pode-se concluir que existiu dificuldades na mudança de mentalidade por parte das chefias, pois sem a existência de resultados estes sentiam-se pouco recetivos à mudança. Com a simulação das linhas consegue-se corroborar a mudança, pois os resultados são promissores, deixando em aberto uma futura implementação pois já sabem o que esperar.
Lean Thinking main objectives is to improve a company’s production level, products quality, stock reduction, lead time reduction, as well as eliminating all types of waste. Innumerous technics are mentioned in this project report, as Just in Time, Value Stream Mapping, Kaizen, standard work ethics, organized work space, visual management technics and others. The project was developed in a traditional clothes confection factory, where it confronts the most usual issues in this sector. We refer to the low productivity, Lead Times excessively long, rework, a production guided to the product, etc. In the first phase, it was developed an exhaustive research on Lean Thinking, starting with the creation of a philosophy, development of techniques and tools. After analyzing and comprehending all concepts for application in an industrial environment, a critical analysis to the production system of the company was processed, with special attention to the tailor section. The objective was the implementation of production lines with a thought in Lean techniques, but as the internship move on, the implementation of the lines was not possible, so we simulated it on the Arena software and it's possible implementation in mode of achieving a change in production. In this analysis we identify all problems in that sector. Once the analysis was complete, we started implementing proposals for improvements, one of them was the change on the “now a days” layout, visual management, 5S program, quality control management and in line production or “fords production line”. After new tools were implemented we compared results and we noticed the rise of production – in case the lines were implemented – 47%, with reduction of the WIP in 64.7% and all so the improvement and rise of other areas. So we can conclude that there was difficulties changing the mentality on the owner and managers, because with no actual results they felt comfortable with the changes. with the simulation of the lines we can see the changes and the results are positive, leaving a future opportunities for implementation because they know what to wait for.
Книги з теми "658.1/1"
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C, Dorf Richard, Nelson Andrew J, and Dorf Richard C, eds. Technology ventures: From idea to enterprise. 3rd ed. Dubuque, Iowa: McGraw-Hill, 2010.
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Inc, Books24x7, ed. Talent magnetism: How to build a workplace that attracts and keeps the best. Boston, Mass: Nicholas Brealey Pub., 2013.
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Marguerite, Reimers, ed. Analysis for financial management. 9th ed. Boston: McGraw-Hill Irwin, 2009.
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The Startup Owners Manual. k&s ranch press, 2012.
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The art of the start: The time-tested, battle-hardened guide for anyone starting anything. New York: Portfolio/Penguin Group, 2004.
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The origin and evolution of new businesses. New York: Oxford University Press, 2000.
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Analysis for Financial Management. McGraw Hill, 2018.
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Zero to One: Notes on Startups, or How to Build the Future. Crown Business, 2014.
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Thiel, Peter, and Blake Masters. Zero to One: Notes on Start-Ups, or How to Build the Future. Ebury Publishing, 2014.
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10
Zero to One Notes on Start-Ups, or How to Build the Future. Virgin Books, 2001.
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