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Статті в журналах з теми "631.491 52":
1
Yoon, Min Yong, and Hyung Ook Kim. "Treatment of colorectal liver metastasis: Comparison of radiofrequency ablation and hepatic resection." Journal of Clinical Oncology 30, no. 4_suppl (February 1, 2012): 637. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.637.
Анотація:
637 Background: Hepatic resection is the mainstay of management for colorectal liver metastases. But, the treatment for colorectal liver metastases requires a multidisciplinary therapeutic strategy. The aim of this study was to compare recurrence and survival rates for patients treated with hepatic resection or radiofrequency ablation (RFA) for colorectal liver metastases. Methods: Between July 2002 and September 2010, 52 patients underwent hepatic resection and 58 underwent RFA for synchronous or metachronous colorectal liver metastases. A retrospective analysis was performed. Patients with extrahepatic metastases were excluded. Results: The two groups had similar mean age, comorbid medical conditions, primary disease stage, and number of tumors. Preoperative median serum carcinoembryonic antigen (CEA) level was significantly higher in the resection group (13.8 ng/mL vs. 3.1 ng/mL; p = 0.001). Median diameter of main tumors was significantly greater in resection group (4.1 cm vs. 2.0 cm; p = 0.002). Recurrence rate after treatment was 46.2% (24/52) in the resection group and 70.7% (41/58) in the RFA group. Marginal recurrence after resection or RFA was observed in 7.6% (4/52) and 46.6% (27/58), respectively (p = 0.003). Median recurrence free survival (28.0 vs. 12.0 months; p = 0.007) and median overall survival (43.0 vs. 26.0 months; p = 0.023) were significantly longer in the resection group. Conclusions: Hepatic resection is the treatment of choice for colorectal liver metastases. RFA for colorectal liver metastases was associated with higher marginal recurrence rate and shorter recurrence free and overall survival.
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Yang, Mo, Huixia Deng, Liuming Yang, Liang Li, Jieyu Ye, Yucai Cheng, Yafang Tan, Beng H. Chong, and Qiang Li. "Coagulation Dysfunction and Hematological Changes in 633 Patients with COVID-19." Blood 136, Supplement 1 (November 5, 2020): 22–23. http://dx.doi.org/10.1182/blood-2020-140274.
Анотація:
Background: A previously unknown beta-coronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. The virus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the international committee for the classification of viruses (ICTV). The disease caused by this virus was named as coronavirus disease 2019 (COVID-19). In addition to pulmonary manifestations, hematological changes such as lymphocytopenia, thrombocytopenia, and coagulation dysfunction can also be found in COVID-19 patients, and the mechanism is still unclear. Case data and methods: A total of 633 COVID-19 patients from Wuhan hospital of China were retrospectively analyzed. Clinical case data of all patients were collected, including gender, age, chronic underlying diseases, outcome, and blood laboratory test results. The hematological features of COVID-19 patients and the factors affecting their outcome were analyzed. Results: Of 633 patients with COVID-19, the median age was 62 years (interquartile range, IQR, 51.0-70.0) and 330 (52%) were men. Lymphocytopenia (lymphocyte count, 1.0 ×109 / L [IQR, 0.7-1.4]) occurred in 317/607 patients (52%), thrombocytopenia (platelet count <100 × 109/ L) occurred in 14/62 death patients (23%), prolonged prothrombin time (13.8 seconds [IQR, 13.1-15.1]) in 289/486 patients (59%), increased D-Dimer level (0.7 mg/L[IQR, 0.2-2.9]) in 230/411 patients (57%) and increased C-reactive protein levels (10.7 mg/L [IQR, 2.2-49.7]) in 217/426 patients (51%) . Compared with the survival patients, death patients have higher white blood cell count (11.7 × 109/L [IQR, 8.4 to 15.6]), neutrophil count (10.8 × 109/L [IQR, 7.8 to 13.9]), neutrophil count/lymphocyte count (20.5 [IQR, 12.4-34.2]), activated partial thromboplastin time (36.8 seconds [IQR, 31.3-42.3]), prothrombin time (17.1 seconds [IQR, 14.7 to 19.7]), D-Dimer level (4.6 mg/L [IQR, 1.0 to 7.8]), C-reactive protein level (111.8 mg/L (IQR, 53.1 to 196.6), and low lymphocyte count (0.5 × 109/L [IQR, 0.3 to 0.7]). The results of logistic multivariate regression analysis showed that age, neutrophil count, prothrombin time, and C-reactive protein were risk factors for patients with COVID-19. Conclusion: Hematological changes are common in patients with COVID-19. The early stage of the disease is mainly characterized by lymphocytopenia, thrombocytopenia, and the late stage may be characterized by more severe lymphocytopenia, even neutrophils elevation, elevated C-reactive protein, and severe coagulation disorder. The pathogenesis may be mediated by a direct viral infection and/or indirect immunopathology. Disclosures No relevant conflicts of interest to declare.
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Forcadell Escouffier, Albert, and Christian Navarro Díaz. "Compatibilidad del control de convencionalidad con la superación del control de constitucionalidad." IUSLabor. Revista d'anàlisi de Dret del Treball, no. 1 (April 22, 2020): 141–56. http://dx.doi.org/10.31009/iuslabor.2020.i01.05.
Анотація:
Comentario de la sentencia del Tribunal Superior de Justicia de Cataluña de 17 de enero 2020, que determina la inaplicabilidad- antes de ser derogado- del artículo 52 d) ET, por el que se establecía como causa válida del despido las ausencias intermitentes en un plazo de dos meses siempre que concurran determinados requisitos. Declaración de improcedencia pese a constatar que en el supuesto analizado concurren todos los requisitos que establecía el artículo 52 d) ET. El Tribunal considera que dicha norma, aunque haya superado recientemente el control de constitucionalidad, no cumple con los estándares superiores de protección que dispensan normas de derecho internacional, (artículos 6.1 del Convenio 158 OIT; artículo 4.1 y 5 del Convenio 155 OIT; artículo 3 de la Carta Social Europea; Artículo 11 del Convenio sobre la eliminación de todas las formas de discriminación contra la mujer de 18/09/1979). Se aplica el control de convencionalidad, manifestación del principio de jerarquía normativa y que forma parte del juicio de aplicabilidad o de selección de la norma aplicable que, a diferencia del juicio de constitucionalidad, corresponde a la jurisdicción ordinaria.
4
Patronek, Gary J., Alan M. Beck, and Lawrence T. Glickman. "Dynamics of dog and cat populations in a community." Journal of the American Veterinary Medical Association 210, no. 5 (March 1, 1997): 637–42. http://dx.doi.org/10.2460/javma.1997.210.05.637.
Анотація:
Objective— To describe dynamics of the pet dog and cat populations in a single community in terms of reproductive patterns and turnover. Design— Cross-sectional, random-digit dial telephone survey. Sample Population— Information gathered from 1,272 households in St Joseph County, Ind that owned a dog or cat between Dec 1, 1993 and Nov 30, 1994 was compared with data on 9,571 dogs and cats received by the Humane Society of St Joseph County during the same period. Results— Prevalence of pet ownership was lower than expected, compared with consumer panel surveys. Eight hundred forty-three of 1,335 (63.1%) dogs were neutered, compared with 816 of 1,023 (79.8%) cats. Cost was cited as a reason that 35 of 441 (7.9%) dogs and 34 of 132 (25.8%) cats were not neutered. Only 33 of 968 (3.4%) dog-owning households reported that their dog had had a litter during the past year, whereas 52 of 662 (7.9%) cat-owning households reported their cat had had a litter of kittens. Most cat litters were unplanned, whereas two thirds of dog litters were planned. Annual turnover in owned pets was 191 of 1,354 (14.1%) dogs and 194 of 1,056 (18.4%) cats. Pet owners underreported relinquishing pets to a shelter in the telephone survey. Clinical Implications— A combination of animal shelter- and human population-based data are needed to describe pet population dynamics in a community. Information about species-specific reproductive patterns is essential in designing population control programs. (J Am Vet Med Assoc 1997;210:637–642)
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Moreno Gené, Josep. "Cual Cid Campeador, la antigua causa de despido por absentismo sigue ganando batallas después de su derogación: la STS de 29 de marzo de 2022 proclama su adecuación a la normativa internacional." IUSLabor. Revista d'anàlisi de Dret del Treball, no. 2 (July 1, 2022): 190–225. http://dx.doi.org/10.31009/iuslabor.2022.i02.06.
Анотація:
Pocos días antes de la derogación del art. 52 d) ET, se dictó la STSJ de Cataluña de 17 de enero de 2020, la cual, revocando la sentencia dictada en instancia, concluía que dicho precepto era contrario a diferentes normas internacionales, en particular, al art. 6.1 del Convenio núm. 158 OIT, sobre la terminación de la relación de trabajo, a los arts. 4.1 y 5 del Convenio núm. 155 OIT, sobre seguridad y salud de los trabajadores, al art. 3 de la Carta Social Europea y, finalmente, al art. 11 Convención sobre la eliminación de todas las formas de discriminación contra la mujer, hecha en Nueva York el 18 de diciembre de 1979 y, por tanto, no resultaba de aplicación al supuesto enjuiciado. La posterior STS de 29 de marzo de 2022, sin embargo, ha venido a casar la referida STSJ de Cataluña de 17 de enero de 2020, permitiendo, una vez más, que la antigua causa de despido por absentismo del trabajador prevista en el art. 52 d) ET haya salido indemne de este embate jurídico. En este estudio se analizan los argumentos invocados por la STSJ de Cataluña de 17 de enero de 2020 para inaplicar el art. 52 d) ET, así como aquellos que han llevado al Tribunal Supremo a casar dicha resolución.
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van Gestel, Yvette, Myrthe van Herk-Sukel, Ignace de Hingh, Harm Rutten, Geert-Jan Creemers, and Valery E. P. Lemmens. "Distant recurrences of colorectal cancer: Incidence, systemic treatment, and survival in daily practice." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 441. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.441.
Анотація:
441 Background: To provide population-based data on the patterns, risk factors, treatment, and survival of distant recurrences of colorectal cancer (CRC). Methods: All patients (n=6,066) diagnosed with CRC M0 in 10 large Dutch non-academic hospitals between 2003 and 2008 were included. By means of active follow-up, data on distant recurrences and systemic treatment were collected. Median follow-up was 4.4 year. Results: 1,074 (18%) patients were diagnosed with distant recurrent disease during follow-up of which 85% within 3 years. Most common affected sites were liver (60%), lung (39%), extra-regional lymph nodes (22%) and peritoneum (19%) (multiple sites possible). Male sex (female=ref (17%), 19%/HR 1.1 95%CI 1.0-1.3), advanced primary tumor stage (T1=ref (4%), T2 9%/HR 3.0 95%CI 1.8-4.9, T3 21%/HR 6.1 95%CI 3.8-9.9, T4 29%/HR 11.0 95%CI 6.7-18.1), advanced lymph node stage (N0=ref (11%), N1 29%/HR 2.8 95%CI 2.4-3.3, N2 41%/HR 4.5 95%CI 3.7-5.4), primary tumor localization (left colon=ref (17%), right colon 16%/HR 0.8 95%CI 0.7-1.0, rectum 25%/HR 1.2 95%CI 1.0-1.4), and tumor differentiation grade (well differentiated=ref [16%], poorly differentiated 26%/HR 1.4 95%CI 1.2-1.7) were associated with increased risk recurrences while chemotherapy for the primary tumor was associated with reduced risk (HR 0.8 95%CI 0.7-0.9). Recurrence rates did not differ between hospitals. 52% of patients with recurrences received systemic therapy, ranging from 34-62% between the 10 hospitals (p<0.01). Half of these patients (52%) was also treated with bevacizumab, ranging from 39-73% between hospitals (p<0.05). Median survival since diagnosis of recurrence was 31 months for patients with lung metastases only, 16 months for liver metastases only, 14 months for lung metastases only, and 5 months for metastases confined to the peritoneum. Conclusions: The development of distant recurrent disease was strongly related to tumor characteristics, but not correlated with hospital of primary treatment. Population-based data on distant recurrences may ultimately contribute to more accurate patient information, and more efficient follow-up schemes.
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Robertson, Neil. "Edited by Kenneth D. Karlin(series editor) and Edward I. Stiefel(volume editor). Progress in Inorganic Chemistry Vol 52. Dithiolene Chemistry: Synthesis, Properties and Applications. Wiley–VCH, 2004, 738 pp; ISBN 0-471-37829-1." Applied Organometallic Chemistry 18, no. 8 (August 2004): 427. http://dx.doi.org/10.1002/aoc.639.
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Perera, A., D. Rajashekar, E. Pereira, and A. Shtaya. "TM3-6 Symptomatic intracranial arachnoid cysts: a centre series." Journal of Neurology, Neurosurgery & Psychiatry 90, no. 3 (February 14, 2019): e16.3-e17. http://dx.doi.org/10.1136/jnnp-2019-abn.52.
Анотація:
ObjectivesTo study the presentation, management and outcomes of symptomatic intracranial arachnoid cysts.DesignRetrospective records review.SubjectsAll cases coded as intracranial cysts.MethodsPatients admitted between Jan-2012 and Sep 2017. Of 56 cases, only 24 were arachnoid cysts. Median age 57 (range 8–81). Mean 49.1±5.0 years, 8 males and 16 females.ResultsMales were significantly younger (34.3±9.1 vs 56.5±5.2 year-old, p=0.03) and outnumbered females. Mean size of cysts was 58.8±6.1 mm (range 18.5–126 mm). Five were located frontally, one fronto-temporal and another fronto-parietal, two parietal and two parieto-occipital, two within third ventricle, one intraventricular, one supra sellar and one intra sellar while eight were posterior fossa. 12 patients had headache, five presented with cognitive and memory issues, five had visual problems, four with limb weakness and two had cerebellar signs. Eight had open fenestration, five endoscopic fenestration, four had aspiration with reservoir, two aspiration only, two marsupialisation, two received ICP monitor and one had no treatment. One reservoir was aspirated three times and another open fenestration had another surgical fenestration. Two had transient infection, two needed VP shunts and one had cysto-peritoneal shunt. mRS (0–2) improved significantly after the treatment (62.5% pre-surgery to 91.7% post-surgery, p=0.016).ConclusionsSymptomatic arachnoid cysts are more common in young males. In the literature, the most common location is middle cranial fossa which is not the case in symptomatic arachnoid cysts as in our series. Although intervention is variable, they are associated with very good outcomes.
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Kang, Jiyeon, and Jinkook Tak. "Development and validity of the communication competence scale of middle managers." Korean Journal of Industrial and Organizational Psychology 32, no. 4 (November 30, 2019): 439–71. http://dx.doi.org/10.24230/kjiop.v32i4.439-471.
Анотація:
This study was intended to develop the communication competence scale for middle manager in organizations and examine its validity. To develop the communication competence scale of middle managers, first, 632 items were extracted through literature review, expert interview and open surveys for middle managers. In the process of developing the items, it was found that there were differences in competencies between communication with superiors and communication with subordinates. Thus it was decided to develop two different scales for each of middle managers’ communication competencies with superior and communication competencies with subordinate. Based on experts’ evaluations on content validity of the items, 81 items for the communication competencies with superior and 78 items for the communication competencies with subordinates were selected. In the first preliminary survey obtained from 338 middle managers, 10 factors and 69 items were selected for the communication competencies with superior and 8 factors and 54 items were obtained for the communication competencies with subordinate. In second preliminary survey obtained from 206 middle managers, 8 factors and 64 items for the communication competencies with superior and 7 factors and 45 items for the communication competencies with subordinate were obtained. To verify validity of the scale, the total sample was divided into two groups. Exploratory factor analyses were conducted for group 1, and a confirmatory factor analysis was conducted for the other group. The results showed that the exploratory factor analysis extracted 8 factors (persuasion, self-confidence, manner, listening, honesty, confirm, logicality, wisdom) and 52 items for the communication competencies with superior, and 7 factors (listening, humor, emotion regulation, modesty, non-verbal expression, consideration, clarity) and 37 items for the communication competencies with subordinate. In the confirmatory factor analysis using structural equation modeling, the models fit the data well. Also the communication competencies of the middle manager were significantly correlated with the criterion variables such as interpersonal relationship competencies and conflict management, and confirming criterion related validity of the scale. Finally, implications, limitatons and directions for future research were discussed.
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Koç, A., and K. Kizilkaya. "Some factors influencing milk somatic cell count of Holstein Friesian and Brown Swiss cows under the Mediterranean climatic conditions." Archives Animal Breeding 52, no. 2 (October 10, 2009): 124–33. http://dx.doi.org/10.5194/aab-52-124-2009.
Анотація:
Abstract. The aim of this study was to determine the influencing factors on somatic cell count (SCC) in the milk of Holstein Friesian (HF) and Brown Swiss (BS) cows raised on three dairy farms under the Mediterranean climatic conditions in Turkey. For a two-year period, farms were visited monthly to measure daily milk yield (DMY) and collect milk samples from each cow during the morning and evening milking. Total of 1 429 SCC readings from 67 HF and 16 BS cows were analyzed by using repeated measures. Breed (P<0.01), lactation number (LN) (P<0.01), milking time (MT) (P<0.05), lactation month (LM) (P<0.01) and the interactions of breed-LM (P<0.05), herd-LM (P<0.01) and LN-LM (P<0.01) effects on SCC were statistically significant as did the co-variable DMY effect (P<0.01). The effect of herd and herd-MT interactions on SCC were statistically insignificant (P>0.05). The SCC means for BS and HF cows were 5.464±0.060 (291 072 cells/ml) and 5.654±0.029 (450 817 cells/ml), respectively. The SCC mean for morning milking (338 065 cells/ml) was 25 850 cells/ml lower than that of evening milking. The LN4 had the highest SCC mean (490 908 cells/ml) and was statistically different from those of LN1 (P<0.01) and LN2 (P<0.05). The SCC level was the highest in the first LM (601 174 cells/ml) and this level then decreased in the later months. Possible reasons for the difference in SCC means between the breeds are different resistance mechanisms against mastitis, different morphological conformations of udders and different milk yields between these two breeds. The insignificant differences found among herds show the similarities of management, milking hygiene and barn conditions. In order to decrease SCC in milk and increase udder health, some precautions need to be taken like improving milking management, hygiene and barn conditions, milking the cow at uniform intervals, feeding the cows after the milking and applying a mastitis control program.
Частини книг з теми "631.491 52":
1
Atkins, Peter, Julio de Paula, and Ronald Friedman. "Extracting information from the wavefunction." In Physical Chemistry: Quanta, Matter, and Change. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199609819.003.0009.
Анотація:
Contents Postulate III: quantum mechanical operators 47 Brief illustration 6.1: The kinetic energy operator in two dimensions 49 Postulate IV: eigenvalues and eigenfunctions 50 Example 6.1: Identifying an eigenfunction 50 Brief illustration 6.2: The wavefunction as an eigenfunction 51 Checklist of concepts 52...
2
Mooers, Arne Ø., Luke J. Harmon, Michaël G. B. Blum, Dennis H. J. Wong, and Stephen B. Heard. "Some Models of Phylogenetic Tree Shape." In Reconstructing Evolution, 149–70. Oxford University PressOxford, 2007. http://dx.doi.org/10.1093/oso/9780199208227.003.0005.
Анотація:
Abstract Phylogenetic trees represent the evolutionary histories of lineages and so bear the impression of the evolutionary forces that gave rise to those lineages. Advances in molecular and computational techniques continually increase the number and size of our phylogenetic estimates. In the 1990s, both we [41] and Purvis [52] surveyed the two main aspects of phylogenetic tree pattern: variation in realized diversification rate among contemporaneous lineages, and changes in realized diversification rates through time. The techniques highlighted in these reviews have been used very successfully (see, e.g. [4, 10, 11, 62, 63]).
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"Anadromous Sturgeons: Habitats, Threats, and Management." In Anadromous Sturgeons: Habitats, Threats, and Management, edited by Thomas Savoy. American Fisheries Society, 2007. http://dx.doi.org/10.47886/9781888569919.ch8.
Анотація:
<em>Abstract</em>.—Atlantic sturgeon <em>Acipenser oxyrinchus</em> are consistent visitors to specific areas of Long Island Sound and the lower portions of Connecticut rivers despite the fact that natal stocks have been extirpated. Atlantic sturgeon have been collected annually in the Connecticut River from 1988 through 2004. Similarly, annual utilization of selected areas in Long Island Sound points to the importance of these areas, probably as foraging sites. By means of pumped gastric lavage, 41 Atlantic sturgeon collected in Long Island Sound in October 2001 were examined to determine the prey items consumed. Ninety-three percent of the fish examined showed evidence of recent feeding. Among the fish that had fed, polychaetes (<em>Pherusa</em>, <em>Glycinde</em>, and <em>Clymenella </em>spp.) comprised 52% of stomach contents on average and all fish had consumed worms (range, 1 to 177). Polychaetes accounted for 2-100% of stomach contents by number and 63% of the diet by weight. Decapods (<em>Squilla</em>, <em>Gilvossius</em>, and <em>Upogebia</em> spp.) were also a prominent prey item, having been eaten by 63% of the fish that had fed. The number of these three mud shrimps eaten ranged from 0 to 49 (mean, 11/fish) and comprised up to 75% of the diet by number and up to 97% by weight (mean, 41%). Other prey included amphipods and pea crabs <em>Pinnixia</em> spp. Eleven subadult Atlantic sturgeon (<2 m total length) collected in the Connecticut River from 2000 to 2002 were also lavaged for stomach contents. Food was obtained from 73% of the fish examined; stomach contents were dominated by polychaetes <em>Scolecolepides</em> spp.
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Jazaeri, Shahram, Burkhard Schaffrin, and Kyle Snow. "A Simple TLS-Treatment of the Partial EIV-Model as One with Singular Cofactor Matrices I: The Case of a KRONECKER Product for $$Q_A = Q_0\otimes Q_x$$." In International Association of Geodesy Symposia. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/1345_2023_229.
Анотація:
AbstractFollowing the pioneering work in the PhD dissertation by Snow (PhD thesis, Rep. No. 502, Div. of Geodetic Sci, School of Earth Sciences, The Ohio State University, Columbus, OH, USA, 2012), the two articles by Schaffrin et al. (J Geodetic Sci 4(1):28–36, 2014) and by Jazaeri et al. (Z für Vermessungswesen 139(4):229–240, 2014) provided a broad overview of the Total Least-Squares (TLS) adjustment within EIV-Models with singular cofactor matrices. Around the same time, Xu et al. (J Geodesy 86:661–675, 2012) proposed a specific algorithm to find the TLS solution within a partial EIV-Model, which has been improved by various authors since, including Shi et al. (J Geodesy 89(1):13–16, 2015), Wang et al. (Cehui Xuebao/Acta Geodaet et Cartograph Sinica 46(8):978–987, 2017), Zhao (Surv Rev 49(356):346–354, 2017), and Han et al. (Surv Rev 52(371):126–133, 2020), to name a few. On the other hand, it is easy to see that the partial EIV-Model is a special case of the general EIV-Model with singular cofactor matrices and thus does not need a separate class of algorithms unless they are more efficient than the standard algorithms. This, however, does not seem to be guaranteed as will be shown in this contribution for the straight-line adjustment under $$Q_A = Q_0 \otimes Q_x$$ Q A = Q 0 ⊗ Q x . As a consequence, we shall argue that, rather than discussing the partial EIV-Model, it would be more worthwhile to make the respective developments within an EIV-Model with singular cofactor matrices directly.
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Seco, Josi M., Emilio Quiqoa, and Ricardo Riguera. "The Theoretical Basis for Assignment by NMR." In The Assignment of the Absolute Configuration by NMR using Chiral Derivatizing Agents. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780199996803.003.0004.
Анотація:
The nuclear magnetic resonance (NMR) spectra of two enantiomers are identical. Thus, the first step in using NMR to distinguish between two enantiomers should be to produce different spectra that eventually can be associated with their different stereochemistry (i.e., the assignment of their absolute configuration). Therefore, it is necessary to introduce a chiral reagent in the NMR media. There are two ways to address this problem. One is to use a chiral solvent, or a chiral agent, that combines with each enantiomer of the substrate to produce diastereomeric complexes/associations that lead to different spectra. This is the so-called chiral solvating agent (CSA) approach; it will not be further discussed here [33–34]. The second approach is to use a chiral auxiliary reagent [13–15] (i.e., a chiral derivatizing agent; CDA) that bonds to the substrate by a covalent linkage. Thus, in the most general method, the two enantiomers of the auxiliary CDA react separately with the substrate, giving two diastereomeric derivatives whose spectral differences carry information that can be associated with their stereochemistry. The CDA method that employs arylalcoxyacetic acids as auxiliaries is the most frequently used. It can be applied to a number of monofunctionals [14–15] (secondary alcohols [35–43], primary alcohols [44–46], aldehyde [47] and ketone cyanohydrins [48–49], thiols [50–51], primary amines [52–56], and carboxylic acids [57–58]), difunctional [13] (sec/sec-1,2-diols [59–61], sec/sec-1,2-amino alcohols [62], prim/sec-1,2-diols [63–65], prim/sec-1,2-aminoalcohols, and sec/prim-1,2-aminoalcohols [66–68]), and trifunctional (prim/sec/sec-1,2,3-triols [13, 69–70]) chiral compounds. Its scope and limitations are well established, and its theoretical foundations are well known, making it a reliable tool for configurational assignment. Figure 1.1 shows a summary of the steps to be followed for the assignment of absolute configuration of a chiral compound with just one asymmetric carbon and with substituents that, for simplicity, are assumed to resonate as singlets. Step 1 (Figure 1.1a): A substrate of unknown configuration (?) is separately derivatized with the two enantiomers of a chiral auxiliary reagent, (R)-Aux and (S)-Aux, producing two diastereomeric derivatives.
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Camargo, Ely Eduardo Saranz, Jéssica Vaz da Silva, Marcos Leandro Alves Nunes, and Domingos Tabajara de Oliveira Martins. "Situational evaluation of brazilian live pharmacy programs." In CONNECTING EXPERTISE MULTIDISCIPLINARY DEVELOPMENT FOR THE FUTURE. Seven Editora, 2023. http://dx.doi.org/10.56238/connexpemultidisdevolpfut-133.
Анотація:
Many of the Living Pharmacy Programs were implemented before the official launch and agreement on the list of herbal medicines selected by the Ministry of Health (MS) and included in the National List of Essential Medicines (RENAME). The objectives of this study were, through applied forms, to explore the criteria used for the selection of medicinal plants, prescription, follow-up and information to patients. The methodology used was a qualitative and quantitative cross-sectional study carried out through forms applied to the Health Departments of Brazilian municipalities that participated in public notices for financial support, published by SCTIE/MS. Of the 80 forms submitted, approximately 52% were answered. It was found that about 16% of the Programs did not present CFT, that 80 Programs participated in Public Calls of the SCTIE/MS, in the period from month 2012 to month 2021. As for the selection of species, 61% took into account the popular use and 37% the National List of Medicinal Plants of Interest to SUS (RENISUS). According to the dosage scheme, 49% were based on scientific evidence, 20% on popular use and 73% on National Forms of the Brazilian Pharmacopoeia. The prescription of medicinal plants in the Live Pharmacy Programs was carried out in 89% by physicians, 58% by pharmacists and 51% by nurses. Patients who received indications for the use of medicinal plants were around 94%. The Live Pharmacies Programs that are in operation present difficulties, mainly financial, even with the public call notices in the distribution of resources for the creation and maintenance of the Programs, these are still insufficient to meet the local demands.
Тези доповідей конференцій з теми "631.491 52":
1
Anderson, J., R. Rothbard, R. Hackworthy, S. Sorensen, P. Fitzpatrick, and V. Harder. "COMPARISON OF INTRAVENOUS ANISOYLATED PLASMINOGEN STREPTOKINASE ACTIVATOR COMPLEX (APSAC) AND INTRACORONARY STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643621.
Анотація:
To compare the reperfusion potential of intravenous anisoy-lated plasminogen streptokinase activator complex (APSAC) a new thrombolytic, and standard therapy with intracoronary streptokinase in acute myocardial infarction (AMI), a randomized multicenter reperfusion trial was performed. Consenting patients with clinical signs of AMI and documented coronary occlusion (flow grade 0 or 1) were randomized to treatment within 6 hours of symptoms (mean, 3.4h) with intravenous APSAC (30 U in 2-4 min) or intracoronary streptokinase (bolus, then 2,000 U/min x 60 min). Reperfusion success was defined as grade 2 or 3 flow at 60 min for intracoronary and 90 min for intravenous therapy. A total of 189 patients (pt) were randomized and 179 pt were evaluable for efficacy. Reperfusion was similar for the two treatments: 52% (49/94) for APSAC and 61% (52/85) for streptokinase (p≤0.2). Success was dependent on initial occlusion grade (p≤0.001): 49% (65/133) for grade 0 (APSAC= 45%, streptokinase=54%), but 78% for grade 1 (APSAC=80%, strepto-kinase=77%). The success of intravenous (APSAC) therapy was also dependent on time to treatment: 59% for ≤4h, versus 36% after 4h (p<0.04). APSAC was well tolerated, the change in mean blood pressure after bolus injection being modest (−11 mmHg). Systemic fibrinolysis was somewhat greater after APSAC than low dose streptokinase: fibrinogen levels averaged 39 ± 4% (SE) of control at 90 minutes after APSAC, versus 64 ± 5% after streptokinase (p<0.01) in the subgroup tested. The rate of bleeding complications was acceptable for both regimens, and other adverse reactions were comparable. Rates of early occlusion were low in both treatment groups, and evolution of ECG and enzymatic indicators were similar. Thus, APSAC provides approximately similar reperfusion results as intracoronary streptokinase, especially when given within 4h, but is easier to administer and is well tolerated.
2
Hadi, Rahat, Mohammad Azam, Pooja Gupta, Satyajeet Rath, Mohammad Ali, Chandra Prakash, Anoop Kumar Srivastava, and S. Farzana. "Comparative dosimetric study between point and volume based brachytherapy in definitive treatment of de novo carcinoma cervix." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685278.
Анотація:
Introduction: Cervical cancer has a high incidence in developing countries including India. Brachytherapy (BT) is an important component in the curative management of carcinoma of the cervix, and significantly improves survival. In gynaecologic BT, correlation between the radiation dose and the normal tissue effects have been assessed using point doses. Since 1985, these points have been defined in the international commission of radiation units and measurements (ICRU-38) report. However GEC-ESTRO recommended volume based treatment planning in their respective series (I-IV). For cervical cancer BT, the correlation of ICRU point doses and volume based treatment planning is investigational till date. Analysis becomes feasible when cross sectional image-based treatment planning for BT using computerized tomography (CT) or magnetic resonance imaging (MRI) is utilised as per GEC-ESTRO recommendation. Methods: It is a retrospective pilot study includes patients (pts.) of carcinoma cervix treated with high dose rate (HDR) BT 9 Gy in 2 fractions 1 week apart. All volume based dosimeteric parameters regarding high risk clinical target volume (HRCTV), intermediate risk clinical target volume (IRCTV) like D90, D100 and for organ at risk (OAR) D 0.1 cc, D 1.0 cc and D 2.0 cc were delineated and dose coverage was analysed in point dose based planning. Results: We have analysed twenty pts. of squamous cell carcinoma (SCC) cervix. The median age was 52 yrs. (41-65 yrs), stage II B 10 pts. & III B 10 pts. The mean value of D90 & D100 in HRCTV during I and II session were 8.64, 6.75 and 5.76, 4.36 Gy respectively. Same values for IRCTV were 6.31, 4.91 and 3.68, 3.15 Gy respectively. Analysis of OARs demonstrated that mean dose received by 0.1, volume of bladder during I and II session received 10.68, 9.47, by 1 cc volume 8.39, 7.57 and by 2 cc volume 6.84, 6.21 Gy respectively. The mean dose received by 0.1 cc of rectum were 11.59, 10.12, by 1 cc volume 9.53, 8.19 and by 2 cc volume 7.76, 6.81 Gy respectively. In point based analysis mean dose delivered to bladder point during I and II session were 5.63, 6.02 and to rectum point were 5.98, 5.46 Gy respectively. Doses to 0.1 cc volume of bladder and rectum were higher in volume based BT as compared to point based BT in respective fractions. Conclusion: Both HRCTV and IRCTV had better dose coverage in 1st fraction as compared to 2nd fraction. Point doses to bladder and rectum is underestimated in point based (ICRU-38) BT. We need more number of pts in prospective randomized trial for more consistent result.
3
Gupta, Ishita, Ayesha Jabeen, Maria K. Smatti, Hamda A. Al-Thawadi, Gheyath K. Nasrallah, Ali A. Sultan, Moussa Al-Khalaf, Semir Vranic, and Ala-Eddin Al-Moustafa. "Co-Prevalence of Human Papillomavirus and Epstein Barr Virus in Healthy Blood Donors in Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0120.
Анотація:
Introduction: Infections with human oncoviruses such as high-risk human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are globally prevalent in the adult population. Both viruses are strongly associated with several types of human carcinomas such as cervical, head and neck, nasopharyngeal and gastric. In the present study, we explored the prevalence of these two oncoviruses in the healthy population of Qatar. Methods: The study included 385 healthy blood donors that reflect diverse nationalities in the Qatari community (Qatar, Egypt, Syria, Jordan, Pakistan, and India). DNA was extracted from the peripheral blood and genotyping was done using PCR and nested-PCR targeting E6 and E7 as well as LMP1 genes of HPVs and EBV, respectively. Results: The age of participants (378 males and 7 females) ranged between 19 and 68 years (mean 37.12 ± 9.3 years). Our data indicate that 55% and 61% of the tested samples were HPVs and EBV positive, respectively. Moreover, we found that there was (40%) co-presence of both HPVs and EBV in our samples. The most common high-risk HPV types in Qatar included HPV 59 (55%), 31 (54%), 52 (49%), 51 (49%), 58 (47%) and 35 (46%). While, HPV 16 and 18 were detected in 38% and 36% of the samples, respectively. Notably, all samples showed multiple HPVs infections. Conclusion: Our study reveals for the first time a high prevalence of both EBV and HPVs among healthy individuals in Qatar. More significantly, most cases had multiple HPV types infection in addition to the co-presence of both viruses in a substantial proportion of the samples. Given the important possible cooperative role of these viruses in human carcinogenesis, preventive measures using available and upcoming vaccines are of paramount importance.
4
Alcantara, Rafaella, Ronaldo Nicácio, Ingryd Araújo, Matheus Soares, Kenneth Barros, Elle Vieira, José Humberto Chaves, Geovana Neiva, and Gentileza Neiva. "Conhecimento sobre infecções sexualmente transmissíveis por jovens de escola pública de Maceió." In XIII Congresso da Sociedade Brasileira de DST - IX Congresso Brasileiro de AIDS - IV Congresso Latino Americano de IST/HIV/AIDS. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/dst-2177-8264-202133p046.
Анотація:
Introdução: A incidência de infecções sexualmente transmissíveis é um problema de saúde pública mundial. Aproximadamente 25% das infecções sexualmente transmissíveis são diagnosticadas em jovens com menos de 25 anos de idade, mas a vulnerabilidade às infecções sexualmente transmissíveis é desigual e está relacionada às condições socioeconômicas e culturais, com pouca informação confiável sobre o assunto. Pesquisas já comprovaram a eficácia da educação sexual na prevenção de comportamento de risco e na idade de início da vida sexual. Objetivo: O objetivo deste trabalho foi verificar o conhecimento dos jovens sobre infecções sexualmente transmissíveis em uma escola pública de Maceió em 2019. Métodos: Trata-se de um estudo transversal, realizado com 84 alunos do 9º ano à 3º série do ensino médio de escola pública de Maceió. Para coleta de dados, foram aplicados questionários com perguntas de identificação e caráter comportamental, com foco nas infecções sexualmente transmissíveis. Resultados: Os alunos tinham entre 14 e 25 anos. Dos 84 alunos, 41 (48,8%) eram do sexo feminino e 64 (76,2%) eram solteiros. Quanto ao comportamento sexual, 66 (78,5%) já haviam iniciado sua vida sexual, tendo a maioria entre 14 e 18 anos de idade. Quanto à prevenção, 52 (61,9%) afirmaram ter feito uso de algum método contraceptivo, sendo a camisinha masculina a mais utilizada (40). Quanto ao conhecimento, 51 (60,7%) receberam algum tipo de orientação sexual dos pais, mas 63 (75,0%) citaram a escola como local onde ouviram falar sobre o assunto, seguido pela internet (19,0%). Dos que já haviam iniciado a vida sexual 66 (78,5%), apenas 41 (62,1%) afirmaram fazer uso de algum método contraceptivo e 17 (25,7%) foram incapazes de conceituar infecções sexualmente transmissíveis. Conclusão: Esses resultados reforçam a importância da educação sexual para os jovens, disseminadores de conhecimento para as gerações futuras, revelando a necessidade de programas de educação sexual para melhorar o quadro mundial de infecções sexualmente transmissíveis.
5
Woods, A. I., and M. A. Lazzari. "ASPIRIN FAILURE TO INHIBIT THE RELEASE OF PLASMINOGEN ACTIVATORS-INHIBITORS BY HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643126.
Анотація:
Platelet-PA-Inhibitors can be released by thrombin, Col laaen( Col) and others.If they are physiologically important,inhibition of their release might facilitate thrombolysis.Intrinsic PA were tested in euclobulins (eug)of PPP and PPP+Washed platelets(WP) ,with and without aspirinf ASA) .treated with UK,SK and Col(20 atfd l2uo/ml) Results(mm2)were:euaPPP:232+78;+3×106WP/ul:217+71;+10%7ul:188+/5 +2×106MP/ul: 157+69:With UK:eugPPP:283+76;+3×l0517P/ul :234+69;+106 WP/ul :172+55;+2×l(PWP/ul :154+48; With SK:euoPPP:303+99;+3×l05WP/ul 252+65;+1067P/ul:203+68;+2×106UP/ul: 174+85;Wi th Col (20ug/ml) :eur PPP:234+97;+3×105WP/ul:160+63;+106WP/ul:141+73;+2×l06WP/ul:129+81; +2×106WP/ul+ASA: 105+31;Wi th Col uc/ml) :euaPPP:230+56;+3×l05NP/ul: 160+52;+106WP/ul:139+44;+2×106wp/ul:126+21;+2×106WP/ul+ASA:118+28. EugPPP+l/P showed lower lysis area.Col induced more decrease of lysis area in euc with WP.ASA did not modify this effect.UK and SK produced higher lysis area only in euoPPP.No difference was observed between high and low doses of Col-effect upon WP.Combined treatment of eucPPP+WP+Col, with UK and SK showed:(mm2):UK-treated eugPPP+2×106WP/ul+Col(29ug/ml):134+25;+ASA and Col(20ug/ml):115+65;+Col(2uc/ml):157+50;+ASA and Col(2uo/ml):133+49; SK-treated eupPPP+2×106WP/ul:+Col(20uo/ml):144+49;+ASA and Col(20ug/ml):128+ 60;+Co1(2ug/ml):173+66;+ASA and Col(2ug/ml):142+36.Col (20ug/ml) produced slight lower lysis area of UK and SK-treated eugPPP+WP. (p:ns). ASA did not modify this effect.Col (2uc/ml) did not produce changes in lysis area of UK and SK-treated eupPPP +WP. ASA produced slight lower lysis area(p:ns).Conclusion: high dosis of Col could release anti UK,anti SK and intrinsic PA-inhibitors from platelets;low dosis of Col could only release fntrinsic PA-inhibi tors. It suggests that anti UK and anti SK release might be triggered by stronger stimuli than intrinsic PA inhibitors.ASA could not inhibit any inhibitors release.We must consider that PA-inhibi tors could be released by different metabolic pathways other than cyclooxygenase pathway.
6
Гронская, С. А., Ж. Е. Белая, Л. Я. Рожинская, Г. А. Мельниченко, Т. А. Дубовицкая, Е. О. Мамедова, С. С. Родионова та ін. "КЛИНИЧЕСКИЕ ПРОЯВЛЕНИЯ, ПРИНЦИПЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ ФОСФАТУРИЧЕСКИХ МЕЗЕНХИМАЛЬНЫХ (ФРФ23-СЕКРЕТИРУЮЩИХ) ОПУХОЛЕЙ: РЕЗУЛЬТАТЫ НАБЛЮДЕНИЯ 40 СЛУЧАЕВ". У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-285.
Анотація:
ЦЕЛЬ: представление клинического опыта по диагностике, лечению и реабилитации пациентов с опухоль-индуцированной остеомаляцией.
МАТЕРИАЛЫ И МЕТОДЫ: в наблюдение были включены 40 пациентов с клинически диагностированной опухоль-индуцированной остеомаляцией, у 34 из которых опухоль была локализована, 27 были
прооперированы и 21 достигли стойкой ремиссии.
РЕЗУЛЬТАТЫ: медиана возраста составила 48 [41 ; 63] на момент диагностики , 43% мужчины, время
от первых симптомов до установления диагноза составило 8 [4 ; 10] лет. Лабораторно у пациентов отмечались гипофосфатемия 0,47 [0,4 ; 0,53] ммоль/л, снижение индекса реабсорбции фосфатов 62 [52 ; 67]%,
и повышение щелочной фосфатазы 183 [112 ; 294] Ед/л. На момент установления диагноза 100% имели
множественные патологические переломы, передвигаться полностью самостоятельно могли лишь 10%,
при этом все испытывали болевой синдром, в том числе 77,5% охарактеризовали боль как нестерпимую
(8-10 баллов по 10-балльной шкале). Среди методов, используемых для обнаружения опухолей, самыми
чувствительными оказались сцинтиграфия с тектротидом с ОФЭКТ/КТ 71,4% (20/28) и МРТ 90% (18/20).
В 35% случаях опухоль была локализована в мягких тканях и в 65% в костной ткани; при этом наиболее
часто опухоль выявлялась в нижних конечностях, далее по частоте локализации была голова. Из 40 человек
у 18 пациентов, в настоящее время, отсутствует ремиссия и пациенты получают консервативное лечение
(препараты фосфора и альфакальцидол n=15 и бурозумаб n=3). В случае достижения ремиссии (n=21),
наблюдался регресс клинической симптоматики и восстановление костной и мышечной масс. Широкое
иссечение опухоли без предварительной биопсии приводило к наилучшему проценту ремиссии 87%.
ВЫВОДЫ: опухоль-индуцированная остеомаляция наиболее часто встречается у лиц средней возрастной группы, характеризуется тяжёлым поражением костной и мышечной ткани с развитием множественных переломов, мышечной слабости и выраженного болевого синдрома. При лабораторной диагностике
следует обращать внимание на гипофосфатемию, снижение индекса реабсорбции фосфатов и повышенную
щелочную фосфатазу. Применение методов функциональной диагностики с меченным аналогом соматостатина к рецептору 2 подтипа и МРТ нижних конечностей и головы с контрастным усилением являются
наиболее точными методами топической диагностики. В случае локализации опухоли рекомендуется
широкое иссечение без предварительной биопсии.