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Статті в журналах з теми "631.382 8"
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Aranda García, Nuria. "Santonocito, Daniela (2020), Gonzalo Argote de Molina, editor de textos medievales. Berlin: Peter Lang. 302 pp. ISBN: 978-3-631-83442-8." Revista de Literatura Medieval 34 (November 21, 2022): 278–83. http://dx.doi.org/10.37536/rlm.2022.34.1.92477.
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Lemański, Janusz. "Michał Karnawalski. Heaven for Elijah? A Study of Structure, Style, and Symbolism in 2 Kings 2,1-18 (European Studies in Theology, Philosophy and History of Religions 30; Berlin: Peter Lang 2022)." Verbum Vitae 42, no. 2 (June 27, 2024): 511–16. http://dx.doi.org/10.31743/vv.16927.
Повний текст джерелаАнотація:
Recenzja książki: Michał Karnawalski. Heaven for Elijah? A Study of Structure, Style, and Symbolism in 2 Kings 2,1-18 (European Studies in Theology, Philosophy and History of Religions 30; Berlin – Bern – Bruxelles – New York: Peter Lang 2022). Ss. 381. ISBN 978-3-631-87134-8.
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Cormick, Gabriela, Ana Pilar Betrán, Janetta Harbron, Armando Seuc, Cintia White, James M. Roberts, Jose M. Belizán, and G. Justus Hofmeyr. "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial." Food and Nutrition Bulletin 41, no. 3 (September 2020): 332–42. http://dx.doi.org/10.1177/0379572120944671.
Повний текст джерелаАнотація:
Introduction: Obesity is a major and challenging public health problem. The aim of this substudy is to evaluate the effect of calcium supplementation on body weight in women recruited in the Calcium and Preeclampsia trial. Methods: Women were recruited before pregnancy and randomized to receive a calcium supplement containing 500 mg of elemental calcium or placebo until 20 weeks’ gestation; all women received 1.5 g from 20 weeks until delivery. Results: A total of 630 women conceived during the study, 322 allocated to calcium and 308 to placebo. Among these, 230 allocated to calcium and 227 allocated to placebo had information on body weight at baseline and at 8 weeks' gestation. During the study period, women allocated to calcium had a mean weight increase of 1.1 (SD ±5.5) kg, whereas those allocated to placebo had a mean increase of 1.5 (SD ±6.1) kg, a mean difference of 0.4 kg (95% −0.4 (−1.4 to 0.6); P = .408). Women classified as obese at the start of the trial had a lower body weight gain at 8 weeks’ gestation (1.0 kg; 95% CI: −3.2 to 1.2; P = .330) and at 32 weeks’ gestation (2.1 kg; 95% CI: 5.6-1.3; P = .225) if they received calcium as compared to placebo. However, none of these differences were statistically significant. Conclusion: The smaller increase in body weight found in women supplemented with 500 mg elemental calcium daily is quantitatively consistent with previous studies. However, in this study, the difference was not statistically significant.
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Heßling, Rüdiger. "Mühlner, Werner; Sommerfeldt, Karl- Ernst (HÄrsg.): Wortarten und Satztypen des Deutschen und Russischen. Frankfurt/M.: Lang, 1993 (Sprache — System und Tätigkeit 8). - ISBN 3-631-45358-2. 161 Seiten, DM 59." Informationen Deutsch als Fremdsprache 22, no. 2-3 (April 1, 1995): 280–82. http://dx.doi.org/10.1515/infodaf-1995-222-362.
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Sazhin, A. F., N. D. Romanova, A. I. Kopylov, and E. A. Zabotkina. "Bacteria and viruses in Arctic Sea ice." Океанология 59, no. 3 (June 26, 2019): 373–82. http://dx.doi.org/10.31857/s0030-1574593373-382.
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We studied vertical distribution of bacteria and viruses in different layers of the Arctic sea ice drilled at the North Pole. The sampled multi-year ice was characterized by uneven vertical distribution of bacterial abundance. This characteristic varied within the range of 8±1.2×103 to 95±2.6×103 cells ml-1. The layers with the maximal bacterial abundance were located in the intermediate and lower layers of the ice cores. Bacterial biomass varied from 0.5 to 5 mg C m-3 with the mean value 1.57±0.2 mg C m-3. The ratio of viral to bacterial abundance varied from 0.6 to 28, with the mean value 12.5. The average total number of phages attached to bacteria was 6.2×103 viral particles ml-1. The number of viral particles located within bacterial cells varied from 2 to 21 particles per a bacterial cell. The frequency of visibly infected bacterial cells (FVIC) calculated for the upper, intermediate and lower layers of the ice was 0.92, 1.23 and 0.8% of the total bacterial abundance, respectively. The overall frequency of infected cells (FIC) calculated for the same layers was 6.3, 8.4 and 0.8% of bacteria numbers, respectively, while the viral-mediated mortality of bacteria (VMB) was 7.1, 9.8 and 6.1 %, respectively. Our data show that during the study period the rate of viral infection of bacterial cells and the viral-mediated mortality of bacterial cells in the multy-year ice of the North Pole were relatively low.
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Ormerod, R. Mark. "Modern chlor-alkali technology, Vol 8. Edited by J Moorhouse. Blackwell Science, Abingdon, Oxfordshire, 2001. 352 pp, ISBN 0 632 05559 6." Journal of Chemical Technology & Biotechnology 79, no. 5 (April 7, 2004): 547. http://dx.doi.org/10.1002/jctb.965.
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Zhang, Ji-Guang, Xia Cao, Phung M.-L. LE, Yan Jin, Ju-Myung Kim, and Wu Xu. "Development of Anode-Free Metal Batteries." ECS Meeting Abstracts MA2022-01, no. 1 (July 7, 2022): 36. http://dx.doi.org/10.1149/ma2022-01136mtgabs.
Повний текст джерелаАнотація:
Ever increasing need for electrical vehicles (EVs) continually pushes the boundary of high-density energy storage systems. To date, the state of the art of lithium (Li) ion batteries (LIBs) consisting of graphite anode and high voltage Li intercalation cathodes cannot satisfy the energy demand from these applications. By replacing graphite anode with Li metal anode (LMA), specific energy density of Li metal batteries (LMBs) can increase by more than 50% because LMA has a much higher specific capacity (3820 mAh g-1) than that of graphite (372 mAh g-1). To further increase the energy density of Li batteries, the concept of “anode-free” Li batteries (AFLBs) has been explored. Similar approach can also be used in “anode-free” sodium (Na) batteries (AFSBs) to further improve their energy densities. In this work, we will report our recent work on the development of AFLBs and AFSBs. The common challenges in these batteries will be analyzed and compared first. Several approaches, including development of novel electrolytes, substrate treatment, optimization of testing protocol and environment conditions, have been adopted to increase the cycle life of these batteries. At last, future perspective and application of anode-fee metal batteries will be discussed. References Niu, C.; Liu, D.; Lochala, J. A.; Anderson, C. S.; Cao, X.; Gross, M. E.; Xu, W.; Zhang, J.-G.; Whittingham, M. S.; Xiao, J.; Liu, J., Balancing interfacial reactions to achieve long cycle life in high-energy lithium metal batteries. Nature Energy 2021. Zhang, J.-G., Anode-less. Nature Energy 2019, 4 (8), 637-638. Pereira, N.; Amatucci, G. G.; Whittingham, M. S.; Hamlen, R., Lithium–titanium disulfide rechargeable cell performance after 35 years of storage. Journal of Power Sources 2015, 280, 18-22. Boyle, D. T.; Huang, W.; Wang, H.; Li, Y.; Chen, H.; Yu, Z.; Zhang, W.; Bao, Z.; Cui, Y., Corrosion of lithium metal anodes during calendar ageing and its microscopic origins. Nature Energy 2021.
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Studies, Kurdish. "Book Reviews." Kurdish Studies 3, no. 2 (October 31, 2015): 217–32. http://dx.doi.org/10.33182/ks.v3i2.416.
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Thomas Schmidinger, Krieg und Revolution in Syrisch-Kurdistan: Analysen und Stimmen aus Rojava, Wien: Mandelbaum, 2014, 262 pp., (ISBN: 978-3-85476-636-0).Bahar Baser, Diasporas and Homeland Conflicts: A Comparative Perspective. Farnham: Ashgate, 2015, 302 pp., (ISBN-10: 1472425626). Bryan R. Gibson, Sold Out? US Foreign Policy, Iraq, the Kurds, and the Cold War, New York: Palgrave, 2015, 284 pp., (ISBN: 978-1137487117). Alex Danilovich, Iraqi Federalism and the Kurds: Learning to Live Together, Farnham, Surrey and Burlington: Ashgate, 2014, 181 pp., (ISBN: 9781409451112).Sherko Kirmanj, Identity and Nation in Iraq, Boulder Colorado and London: Lynne Rienner, 2013, xviii + 321 pp., (ISBN: 978-1-58826-885-3).Cenk Saraçoğlu, Kurds of Modern Turkey: Migration, Neoliberalism and Exclusion in Turkish Society, London : IB Tauris, 2011, 228 pp., (ISBN: 978-1-84885-468-0).Tatort Kurdistan. Demokratische Autonomie in Nordkurdistan, Rätbewegung, Geschlechterbefreiung und Ökologie in der Praxis. Hamburg: Tatort Kurdistan/Informationsstelle Kurdistan, 2012, 183 pp., (ISBN: 978-3-941012-60-8).Anja Flach, Ercan Ayboğa and Michael Knapp, Revolution in Rojava, Frauenbewegung und Kommunalismus zwischen Krieg und Embargo, Hamburg: VSA Verlag, 2015, 352 pp., (ISBN: 978-3-89965-665-7).
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Mahida, Y. R., M. Ceska, F. Effenberger, L. Kurlak, I. Lindley, and C. J. Hawkey. "Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis." Clinical Science 82, no. 3 (March 1, 1992): 273–75. http://dx.doi.org/10.1042/cs0820273.
Повний текст джерелаАнотація:
1. We studied neutrophil-activating peptide-1/interleukin-8 in inflammatory bowel disease. 2. Mucosal levels of neutrophil-activating peptide-1/ interleukin-8 were significantly higher in patients with active ulcerative colitis [median 74.5 (range 17.7–450.8) pg/mg] than in patients with active Crohn's disease [10.4 (4–46.9) pg/mg; P<0.002] or in normal control subjects [10.4(4–16.6) pg/mg; P <0.002]. 3. Circulating neutrophil-activating peptide-1/interleukin-8 was generally undetectable but there were higher levels of anti-neutrophil-activating peptide-1/interleukin-8 antibodies in patients with active ulcerative colitis [62.9 (3.4–239) ng/ml] than in patients with active Crohn's disease [5.9 (2.1–18.10) ng/ml; P <0.001] or in control subjects [6.1 (3.2–15.8) ng/ml; P <0.001]. 4. Neutrophil-activating peptide-1/interleukin-8 may be of specific functional importance in mediating inflammation in ulcerative colitis.
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Castillo Gallegos, Epigmenio, Rodrigo Rascón Chincoya, Diana García González, Jesús Jarillo Rodríguez, Andrés Aluja Schunemann, and Len ‘t Mannetje. "Comportamiento ingestivo de vacas en una asociación grama nativa/Arachis pintoi en el trópico húmedo veracruzano." Revista Mexicana de Ciencias Pecuarias 5, no. 4 (April 24, 2015): 487. http://dx.doi.org/10.22319/rmcp.v5i4.4019.
Повний текст джерелаАнотація:
Se introdujo la leguminosa Arachis pintoi CIAT 17434 (AP) en una pastura de gramas nativas, para estudiar su efecto sobre la conducta de ingestión del animal al pastar, en la época lluviosa del trópico húmedo del estado de Veracruz. Los tratamientos fueron gramas nativas (PN, testigo) y AP asociado a gramas nativas (PNA). La rotación fue 1 día de pastoreo/20 días de recuperación con carga de 3.2 vacas F1 (Holstein x Cebú)/ha. Las diferencias se probaron a P<0.05, presentándose primero las medias ± error estandar de PNA y luego de PN. Hubo diferencias entre tratamientos en cantidad de materia seca (MS) presente antes del pastoreo (4,225 ± 212 vs 3,314 ± 212 kg/ha), así como en proteína cruda (15.1 ± 0.45 vs 10.6 ± 0.5 %) y materia orgánica (MO) digestible (67.65 ± 1.7 vs 64.1 ± 2.4 %) de la extrusa esofágica. El tiempo de pastoreo (367 ± 11 vs 380 ± 11 min/24 h) fue similar entre tratamientos y el de rumia diferente (291 ± 8 vs 379 ± 8 min/24 h). No hubo diferencias en consumo de MO calculado por Cr-indigestibilidad in situ (2.09 ± 0.11 vs 2.16 ± 0.11 kg MO/100 kg PV), pero por comportamiento ingestivo, si las hubo (1.54 ± 0.12 vs 2.02 ± 0.12). La producción diaria (kg/vaca) de leche ordeñada (6.8 ± 0.4 vs 6.1 ± 0.4) y consumida por el becerro (4.4 ± 0.4 vs 3.8 ± 0.5) fueron similares, pero la producción total fue diferente (9.0 ± 0.6 vs 7.2 ± 0.6 kg/animal/ día).
Дисертації з теми "631.382 8"
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Chamberlain, Peter. "Moaning like a dove : Isaiah's dove texts as the background to the dove in Mark 1:10." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/7916.
Повний текст джерелаАнотація:
There is no consensus regarding the interpretation of the "Spirit like a dove" comparison in Jesus' baptism (Mk 1:10). Although scholars have proposed at least fifty different interpretations of the dove comparison, no study appears to have considered Isaiah's three dove texts as the background for the Markan dove (cf. Is 38:14; 59:11; 60:8). This neglect is surprising considering the abundance of Isaianic allusions in Mark's Prologue (Mk 1:1-15), and the growing awareness that Isaiah is the hermeneutical key for both the Markan Prologue and Jesus' baptism within it. Indeed, Mark connects the dove image inseparably to the Spirit's "descent" from heaven, which alludes to Yahweh's descent in a New Exodus deliverance in Isaiah 63:19 [MT]. Furthermore, each Isaianic dove text uses the same simile, "like a dove" or "like doves," which appears in Mark 1:10, and shares the theme of lament and restoration which fits the context of Mark's baptism account. This study therefore argues that the dove image in Mark 1:10 is a symbol which evokes metonymically Isaiah's three dove texts. So the Spirit is "like a dove" not because any quality of the Spirit resembles that of a dove, but because the dove recalls the Isaianic theme of lament and restoration associated with doves in this Scriptural tradition. After discussing the Markan dove in terms of simile, symbol, and metonymy, the study examines the Isaianic dove texts in the MT and LXX and argues that they form a single motif. Next, later Jewish references to the Isaianic dove texts are considered, while an Appendix examines further dove references in Jewish and Greco-Roman literature. Finally, the study argues that the Markan dove coheres in function with the Isaianic dove motif and symbolizes the Spirit's effect upon and through Jesus by evoking metonymically the Isaianic dove texts.
Книги з теми "631.382 8"
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Кудін, В. О. Зоряний шлях. Київ: Парламентське видавництво, 2004.
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Кудін, В. О. Зоряний шлях. Київ: Парламентське видавництво, 2004.
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Войтович, Леонтій. Нащадки Чингіз-хана: вступ до генеалогії Чингізидів-Джучидів. Львів, 2004.
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L.Sihler, Andrew. "Vowels and Diphthongs." In New Comparative Grammar of Greek and Latin, 35–45. Oxford University PressNew York, NY, 1995. http://dx.doi.org/10.1093/oso/9780195083453.003.0006.
Повний текст джерелаАнотація:
Abstract The normal correspondences of the vowels and short diphthongs may be surveyed in the accompanying table. The long diphthongs (63-4), and the syllabic liquids (93-8), nasals (99-100), and laryngeals (101-2) are treated separately. r.PIE LONG VOWELS and sequences of SHORT VOWELS PLUS IARYNGEAL with few exceptions (mostly in G, 49-50) have identical reflexes in the IE languages. As a consequence it is not always possible to determine whether a given long vowel, for example the ii of L miis ‘mouse’, continues PIE “ii or “uH 2. GREEK. The Greek vowels and diphthongs reflect most nearly those of the parent speech, though the system is not as conservative as used to be taught. The most obvious innovations are Attic-Ionic rather than generally Greek, namely the change of” a to T/ (54-6), and the (purely phonetic) change of “u and “ii to front rounded vowels /ii ii/ (38a). There are in addition a number of pan-Greek metatheses, syncopes, and assimilations, and a variety of conditioned lengthening and shortening.
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Fernández Ramos, Severiano. "PREVENCIÓN, ASISTENCIA Y REINSERCIÓN EN MATERIA DE DROGAS Y ADICCIONES." In EL DERECHO DE SALUD PÚBLICA Y POLÍTICAS SOCIALES E IGUALDAD DE ANDALUCÍA, 379–456. Instituto Andaluz de Administración Púbica, 2016. http://dx.doi.org/10.46735/iaap-pub.48.149.
Повний текст джерелаАнотація:
SUMARIO: 1. MARCO LEGAL Y CONCEPTUAL 1.1. Introducción 1.2. Evolución de la normativa autonómica sobre drogodependencias. 1.3. Conceptos básicos 1.3.1. Drogas 1.3.2. Drogodependencias y adicciones 1.3.3. Titulares de derechos y principios 2. ORGANIZACIÓN ADMINISTRATIVA Y COMPETENCIAS 2.1. Administración del Estado 2.2. Administración Junta de Andalucía 2.2.1. Competencias de Administración de la Junta de Andalucía 2.2.2. Órganos de coordinación y gestión 2.3. Administraciones Locales 3. PLANIFICACIÓN 3.1. Los Planes Nacionales sobre Drogas 3.2. El Plan Andaluz sobre Drogas 3.3. Planes locales sobre drogas. 4. PARTICIPACIÓN E INICIATIVA SOCIAL 4.1. Participación 4.2. Iniciativa social 4.2.1. Fomento de la iniciativa social 4.2.2. Autorización, registro y acreditación de entidades y centros 4.2.3. Convenios de colaboración 5. LA PREVENCIÓN DEL CONSUMO DE DROGAS 5.1. Las políticas sobre drogas y adicciones 5.2. Reducción de la demanda 5.3. Control de la oferta 5.3.1. Drogas no instituzionalizadas 5.3.2. Drogas institucionalizadas 6. LA ATENCIÓN A DROGODEPENDIENTES 6.1. La atención en general 6.1.1. La red andaluza de atención a las drogodependencias y adicciones 6.1.2. Especialización versus normalización 6.2. Actuaciones de asistencia. 6.2.1. Competencias 6.2.2. Centros y recursos para la asistencia de drogodependientes 6.2.3. Programas de Reducción del Daño 6.3. Actuaciones de incorporación social 6.3.1. Competencias y programas 6.3.2. Centros y recursos para la rehabilitación e incorporación social 6.4. Actuaciones de inserción laboral 6.4.1. Reserva de puesto de trabajo 6.4.2. Programa de Red de Artesanos 6.4.3. Programa Arquímedes 7. FINAL 8. BIBLIOGRAFÍA Y DOCUMENTACIÓN
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Allison, Penelope M. "Casa del Fabbro (I 10,7)." In The Insula of the Menander at Pompeii. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780199263127.003.0016.
Повний текст джерелаАнотація:
Giornale degli Scavi A,VI,6 (May 1912–Mar. 1929): 545 (Apr. 1928). A,VI,7 (Apr. 1929–Dec. 1935): 258–302 (intermittently from 12 Dec. 1932 to 28 Feb. 1933). Elia 1934: 278–308. The main excavations of this house were carried out between December 1932 and February 1933. The standard of excavation recording is perhaps more careful than that in the Casa del Menandro. More precise locations of objects are reported but sometimes with incorrect compass points. Elia has often published inventory numbers which do not concord with those in the Giornale degli Scavi. Dimensions: l.: 170 mm (GdSc). Description: quadrangular lock. Present location: unknown, not inventoried at time of excavation. Discussion: Relatively large lock, probably for structural door. Possibly one of the locks or possible lock fragments in the Casa del Fabbro Supplement: see cat. nos. 8, 10, 21, 34, and 68. See discussion on locks and keys. Present location: unknown, not inventoried at time of excavation. Discussion: possibly one of fragments in the Casa del Fabbro Supplement: see cat. nos. 41 and 92. Present location: unknown, not inventoried at time of excavation. Dimensions: l.: 150 mm (GdSc). Description: key with six teeth. Present location: unknown, not inventoried at time of excavation. Discussion: Probably similar type to cat. no. 136. Possibly key in the Casa del Fabbro Supplement: see cat. no. 23. See discussion on locks and keys. Dimensions: small key. Present location: unknown, not inventoried at time of excavation. Discussion: see discussion on locks and keys. Dimensions: l.: 350 mm (GdSc). Description: with knob. Present location: unknown, not inventoried at time of excavation. Discussion: possibly one of the door-latch remains in the Casa del Fabbro Supplement: see cat. nos. 16, 34–5, 38, and 63. Present location: unknown, not inventoried at time of excavation. Discussion: possibly one of door-latch fragments in the Casa del Fabbro Supplement: see cat. nos. 34–5, 38, and 63. Description: studs, sixteen of which have a hole in the centre. Present location: unknown, not inventoried at time of excavation. Discussion: see discussion on studs. Description: nails and remains of nail heads. Present location: unknown, not inventoried at time of excavation. Discussion: possibly some of nails in the Casa del Fabbro Supplement: see cat. nos. 43–7, 73, 75, and 79.
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James, Simon. "The Plateau Zone West of G St." In The Roman Military Base at Dura-Europos, Syria. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198743569.003.0019.
Повний текст джерелаАнотація:
One of the first structures explored at Dura in 1920, this temple (or perhaps better, sanctuary: Buchmann 2016, 116) was subsequently completely excavated but never fully published. Preliminary accounts were written by the excavators (Cumont 1926, 29–41; PR 2, 11–12, 67–9 (Pillet), PR 4, 16–19 (Pillet); Rostovtzeff 1938, 68–75 and pl. VI) and it has been much discussed since (Downey 1988, 105–10 for overview and references; Dirven 1999, 326–49 for the Palmyrene evidence; Leriche et al. 2011, 28). It remained a temple through the Roman period, apparently no part of it other than, presumably, the upper levels of city wall Tower 1 being used for secular military purposes. However, its continued existence in the farthest corner of the military base, and its attested use for worship by the Roman military community, demand discussion here. Indeed one of the very first military discoveries was the Terentius wall painting on the N wall of the temple’s room A, depicting a Roman military sacrifice by cohors XX Palmyrenorum before a triad of its national deities and the Tychai of Dura and Palmyra (Pl. I; Breasted 1922; Cumont 1923; Breasted 1924, 94–101, pl. XXI). Cumont consequently called the sanctuary the ‘Temple of the Palmyrene Gods’ (Cumont 1926, 29). In recent decades it has been more usually known as the ‘Temple of (i.e. Palmyrene) Bêl’, following Rostovtzeff (1938, 51), although in Parthian times it was probably dedicated to Zeus (Welles 1969, 63; Millar 1998, 482; Kaizer 2002, 122). No evidence indicates Palmyrene worship in the Parthian-era temple (Dirven 1999, 327–8). There is no consensus on the name for the sanctuary, so I follow MFSED’s ‘Temple of Bêl’ (Leriche et al. 2011, 28; also now Kaizer 2016b, 37–41). Described as laying in ‘J3/5’ by the Yale expedition, it actually lies N of these blocks in an area MFSED has labelled J9 (Leriche et al. 2011, 28–30). During the third century when the temple lay within the Roman base area, it did become the focus of Palmyrene cults, likely ‘related to Palmyrene soldiers or people associated with them’ (Dirven 1999, 328).
Тези доповідей конференцій з теми "631.382 8"
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Ajiferuke, Isola. "Role of Information Professionals in Knowledge Management Programs : Empirical Evidence from Canada." In 2003 Informing Science + IT Education Conference. Informing Science Institute, 2003. http://dx.doi.org/10.28945/2625.
Повний текст джерелаАнотація:
The objective of this study is to provide empirical evidence of the role of information professionals in knowledge management programs. 386 information professionals working in Canadian organizations were selected from the Special Libraries Association’s Who’s Who in Special Libraries 2001/2002 and questionnaire with a stamped self-addressed envelope for its return was sent to each one of them. 63 questionnaires were completed and returned, and 8 in-depth interviews conducted. About 59% of the information professionals surveyed are working in organizations that have knowledge management programs with about 86% of these professionals being involved in the programs. Factors such as gender, age, and educational background (i.e. highest educational qualifications and discipline) did not seem to have any relationship with involvement in knowledge management programs. Many of those involved in the programs are playing key roles, such as the design of the information architecture, development of taxonomy, or content management of the organization’s intranet. Others play lesser roles, such as providing information for the intranet, gathering competitive intelligence, or providing research services as requested by the knowledge management team.
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Sidelnikova, A. A. "COMPARATIVE ANALYSIS OF SOME BIOCHEMICAL BLOOD PARAMETERS IN OPISTHROCHISIS." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. VNIIP – FSC VIEV, 2024. http://dx.doi.org/10.31016/978-5-6050437-8-2.2024.25.383-387.
Повний текст джерелаАнотація:
Biochemical blood parameters were analyzed in the chronic phase of opisthorchiasis in rabbits in an experiment for the first time. Sexually mature males were infected with 50 Opisthorchis felineus (Rivolta, 1884) metacercariae isolated from the muscle tissue of Leuciscus leuciscus per one animal (n = 10). After confirmation of occurred invasion in the animals, serum was examined at 61 months (about 5 years). Glucose, urea, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were determined in serum using a hematological analyzer. Own data obtained in the acute phase of opisthorchiasis at 1.5 months after infection were used as test and control. We found that glucose corresponded to normal values in the chronic phase as compared to the acute phase, and the data were statistically significant. Urea was normal as compared to the acute phase, and the data were statistically significant. AST level was within normal range and ALT was above normal values as compared to the acute phase. The data for liver enzymes among the invasion periods were not statistically significant. Thus, the studied biochemical parameters returned to normal in the chronic phase of opisthorchiasis compared to the acute phase except for ALT.
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Демидова, Т. Ю., К. Г. Лобанова та А. С. Кочина. "КЛИНИЧЕСКИЕ И ЛАБОРАТОРНЫЕ ОСОБЕННОСТИ ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА, ГОСПИТАЛИЗИРОВАННЫХ В ЦЕНТР СПАСЕНИЯ КОНЕЧНОСТЕЙ В 2019-2020 ГГ." У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-100.
Повний текст джерелаАнотація:
Поражение нижних конечностей (НК) при сахарном диабете (СД) является частой причиной ампутации,
что приводит к значительному снижению качества жизни пациентов. Несмотря на широкий спектр совре-
менных методов лечения СД, прогрессивный рост количества ампутаций у данных пациентов является
актуальной проблемой.
ЦЕЛЬ: изучить клинико-лабораторные характеристики пациентов центра спасения конечностей (ЦСК)
с сахарным диабетом 2 типа (СД2).
МАТЕРИАЛЫ И МЕТОДЫ: проведен ретроспективный анализ 729 историй болезни пациентов, имею-
щих СД2 и госпитализированных в ЦСК ГБУЗ ГКБ им. В.П. Демихова в период с 2019 по 2020 гг.
РЕЗУЛЬТАТЫ: всего в анализ вошло 729 пациентов. Медиана возраста – 66,0 лет [59,0; 73,0]. У 50,89%
(n=371) пациентов стаж СД2 более 10 лет. Средний ИМТ составил 31,82±0,43 (95% ДИ 30,96-32,67).
Наиболее частой сопутствующей патологией являлась артериальная гипертензия (АГ) – 89,57% (n=653).
У 63,24% (n=461) пациентов имелась ИБС, из них у 19,62% (n=143) был инфаркт миокарда в анамнезе.
У 16,87% (n=123) наблюдалось острое нарушение мозгового кровообращения, у 44,31% (n=323) – хрони-
ческая болезнь почек (ХБП).
Медиана гликированного гемоглобина (HbA1c) составляла 7,8% [6,7; 9,1]. Медиана гликемии –
9,9 [7,2; 13,8] ммоль/л.
На инсулинотерапии находились 75,99% (n=554) пациентов, из них 14,9% получали только инсулин
(n=83), а 85,01% (n=471) – базальный инсулин и пероральные сахароснижающие препараты (ПССП). Только
ПССП получали 14,95% (n=109) пациентов. 14,13% (n=103) получали метформин, 6,31% (n=46) – ингиби-
торы дипептидилпептидазы-4 (иДПП-4), 0,41% (n=3) – агонисты глюкагоноподобного пептида (аГПП-1),
3,70% (n=27) – ингибиторы натрий-глюкозного ко-транспортера (иНГЛТ-2), 16,46% (n=120) – препараты
сульфонилмочевины. Лечение статинами получали 38,59% пациентов (n=225). Среди имевших АГ терапия
ингибиторами ренин-ангиотензин-альдостероновой системы была назначена 79,46% (n=472) пациентам,
блокаторами кальциевых каналов – 20,55% (n=128).
При поступлении у 72,7% пациентов (n=530) был диагностирован СДС. У 27,2% (n=199) – облитериру-
ющий атеросклероз артерий НК, из них у 66% (n=133) – критическая ишемия НК. У 26% пациентов с СДС
(n=244) имела место гангрена, у 34,5% (n=183) – язва, у 23,9% (n=127) – флегмона, у 9,05% (n=48) – абсцесс,
остеомиелит встречался у 11,8 (n=63) пациентов данной группы.
В отделении 15,5% (n=113) пациентам провели реваскуляризацию, 14,4% (n=105) было проведено стен-
тирование, 1,1% (n=8) – шунтирование. Ампутация НК была выполнена 51% пациентов (n=372), из них 9,95%
(n=37) – высокая ампутация, 90,05% (n=335) – низкая ампутация. Среди пациентов с СДС только местное
лечение получили 33,5% (n=244), антибактериальную терапию получали 7,2% пациентов (n=53). Выписаны
с улучшением 98,5% (n=718) пациентов, летальность стала исходом госпитализации в 1,5% случаев (n=11).
ВЫВОДЫ: большинство пациентов ЦСК с СД2, госпитализированных в 2019-2020 г., были старше 60 лет
(68,86% (n=502)), имели ожирение (64,14% (n=127)), а также атеросклеротические сердечно-сосудистые за-
болевания (АГ – 89,57% (n=653), ИБС – 63,24% (n=461), ОНМК в анамнезе – 16,87% (=123)). У 50,89% (n=371)
пациентов стаж СД2 составлял более 10 лет, у 44,31% (n=323) имелась ХБП. Исходом 51% (n=372) госпита-
лизаций стала ампутация НК, что требует более тщательного подхода к профилактике и своевременной
диагностике поражения НК у пациентов с СД.
4
Grego, Edita, Ljiljana Pavlović, Tatjana Bojović-Alekić, Maja Vivoda, Marijana Krivokapić, and Miljan Ljubičić. "Chlamydial infections in the era of modern technology: The role of the laboratory in improving the reproductive health of young people." In Proceedings of the International Congress Public Health - Achievements and Challenges, 167. Institute of Public Health of Serbia "Dr Milan Jovanović Batut", 2024. http://dx.doi.org/10.5937/batutphco24120g.
Повний текст джерелаАнотація:
Background: Chlamydia is a sexually transmitted infection caused by the Chlamydia trachomatis bacterium. The infection is often asymptomatic, both in men and women. Urogenital infections can present as cervicitis, salpingitis, endometritis and pelvic inflammatory disease in women; as orchitis, epididymitis and prostatitis in men and as urethritis and proctitis in men and women. Chlamydia trachomatis infection can lead to tubal factor infertility, ectopic pregnancy and chronic pelvic pain Those infections can also be transmitted from mother to child during labour, leading to disease in the neonate. Methods and Objectives: In the Department of Molecular Microbiology of Institute of Public Health of Serbia (IPHS), in first 6 month of 2024. were analysed 4161 samples by RT PCR method (Vector-best). Because of the great importance of this infection on reproductive health, the aim of this study is to examine the frequency of C. trachomatis infection in different age groups among patients from IPHS. Results: In the first 6 months of 2024 a total of 385 laboratory-confirmed cases of Chlamydia trachomatis were registered in the Public Health Service of Serbia (PHSS) from IPHS and other labs in Serbia. During that period, at IPHS from 4161 samples, 63 (1,51%) samples were positive. The largest number of lab cases was in the age groups of 20-24 years (32), 25-29 years (7), 35-39 years (6) and 30-34 (5). Out of 63 positive results, the majority were women, 58 (92%), while there were only 5 (8%) men. Conclusions: The high rate of reported chlamydia diagnoses among young adults indicates the need for further control. The strategy should include primary prevention interventions for at-risk populations, evidence-based case management, and effective surveillance activities. Offering young women (under 25 years) a chlamydia test can reduce their risk of developing pelvic inflammatory disease.
5
"CARACTERÍSTICAS DE LOS JUGADORES DE APUESTAS ADOLESCENTES CON PATOLOGÍA DUAL." In 23° Congreso de la Sociedad Española de Patología Dual (SEPD) 2021. SEPD, 2021. http://dx.doi.org/10.17579/sepd2021o043.
Повний текст джерелаАнотація:
El juego patológico es una adicción comportamental asociada a problemas psicosociales y de salud que se intensifican cuando converge con un trastorno psiquiátrico. Objetivo: El presente estudio intentó localizar factores que diferencian a los adolescentes y jóvenes adultos con esta patología dual, de aquellos que solo presentan uno de estos dos síntomas. Método: 389 jugadores con edades entre 12-22 años (M=17.27; DT=2.01) participaron en el estudio. Estrategia analítica e instrumentos: mediante un análisis discriminante se estudiaron las diferencias entre jugadores con patología dual y los que solo presentaron trastorno mental (medido con el GHQ-12) o juego problemático (medido con el SOGS-RA). Se incluyeron en el análisis dos variables de juego (máximo dinero apostado y número de diferentes juegos en el último año) y dos rasgos psicológicos asociados a una pobre salud mental (escala de Impulsividad de Plutchik y escala breve de búsqueda de sensaciones de Hoyle et al.). Resultados: Se encontró una única función discriminante significativa (λ de Wilks=.634; χ2(8) =161.293; p=.000; R canónica=.595) que logró explicar el 96.8% de la variabilidad. Dicha función se basó, fundamentalmente, en las variables de juego cuyos coeficientes estandarizados fueron .841 y .326 para el dinero apostado y el número de juegos en los que se apostó. La función discriminante logró clasificar correctamente el 66.3% de los participantes en los tres grupos originales. Conclusiones: Las variables relacionadas con las apuestas fueron las que mejor predijeron la pertenencia de los jugadores a uno de los tres grupos: (a) patología dual, (b) problemas de juego, y (c) trastorno mental. Este hallazgo sugiere que la prevención de patología dual en jugadores adolescentes debe centrarse en la reducción de la cantidad de dinero apostado y la diversidad de juegos en los que participan.
6
Ardanov, Pavlo, Serhii Razanov, Mykola Kutsenko, Alla Razanova, Yuriy Dmytruk, Vasyl Cherlinka, Iryna Gumeniuk, et al. "SUSTAINABLE RESTORATION OF AGRICULTURAL LANDSCAPES AFFECTED BY MILITARY ACTIVITIES." In SUSTAINABLE RESTORATION OF AGRICULTURAL LANDSCAPES AFFECTED BY MILITARY ACTIVITIES, edited by Svitlana Sydorenko. Kyiv: Talkom, 2023. http://dx.doi.org/10.36994/978-966-388-681-7-2023-71-1-71.
Повний текст джерелаАнотація:
Since 24 of February 2022, military activities following the large-scale invasion of russian troops into Ukrainian territory lead to degradation of agricultural landscapes affecting 20-30 % of Ukrainian territory and 182 900 km2 (during the first 8 months) of arable soil. Main ecosystem damage include soil and water pollution (including Pb, Cd, Cr, As, Hg, Сu, Ni, Zn, W), soil compaction, breaking soil structure and reducing its water holding capacities, mixing and rotating soil layers, creation of craters, increased erosion and desertification, damage to soil life, regional fauna, and natural and semi-natural vegetation that increases effects of droughts and frosts and detrimental impact of climate change on agriculture. Consolidated actions of Ukrainian and international researchers and experts are needed to designing strategies for restoring agricultural landscape with the aims of increasing their multifunctionality and agroecosystem service provisioning capacities, promoting agroecological transition and support small, medium, and family farming, regionalizing green energy production, protecting and increase biodiversity. Our conference promoted the use of agroforestry, cultivation of bioenergy crops in diversified systems, and the application of microbial biopreparations for accelerated bioremediation, for transition to regenerative and carbon farming, and for increasing regional environmental resilience and economic and energy self-sufficiency. Prioritizing these solutions which are in line to major agrifood strategies in Germany and in the EU is not only important for the European integration of Ukraine, but also for (over)compensating detrimental effects of military activities on carbon emission (31 mln t during the first 7 month) and carbon sequestration (3 mln ha of affected forests). The aim of our conference is to facilitate knowledge exchange and networking between Ukrainian, German, and international researchers and experts and to present approaches and tools for sustainable landscape restoration to the range of institutions and initiatives involved in the restoration projects in Ukraine.
7
Сокуева, Х. Ю. "КОМОРБИДНОСТЬ ПАЦИЕНТОВ С ОСТРЫМ ПЕРЕДНИМ Q ИНФАРКТОМ МИОКАРДА И САХАРНЫМ ДИАБЕТОМ 2 ТИПА". У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-91.
Повний текст джерелаАнотація:
ЦЕЛЬ: изучить коморбидность больных с сахарным диабетом 2 типа (СД2), получающих лечение по по-
воду переднего острого инфаркта миокарда (ОИМ) с зубцом Q.
МАТЕРИАЛЫ И МЕТОДЫ: в исследование вошли 90 пациентов с передним ОИМ с зубцом Q, получаю-
щие гликлазид (n=30, 1-группа), глимепирид (n=30, 2 группа) и глибенкламид (n=30, 3 группа). Изучались
липидограмма, гликированный гемоглобин (HbA1C), креатинин, альбуминурия, осматривались неврологом,
окулистом, рассчитывался индекс массы тела (ИМТ).
РЕЗУЛЬТАТЫ: мужчин было 43 (47,7%), а женщин 47 (52,3%). Возраст мужчин составлял 60±9 [57-62] лет,
женщин 53±8 [50-55]. В 1 группе ИМТ составил 30,4±2,1[29,6-31,1] кг/м2, во 2 группе ИМТ 31,6±2,3 [30,7-32,4],
а в 3 группе- 31,2±3,9 [29,8-32,6] кг/м2. При проведении анализа корреляционной взаимосвязи ИМТ от стажа
СД2 была установлена высокой тесноты обратная связь (р<0,001, rxy= -0,782). При увеличении стажа СД2
на 1год следует ожидать уменьшение ИМТ на 0,402. Полученная модель объясняет 61,2% наблюдаемой
дисперсии. При оценке связи ИМТ и возраста была установлена умеренной тесноты обратная связь. При
увеличении возраста на 1 следует ожидать уменьшение показателя ИМТ на 0,319. При оценке связи ИМТ
и дозы препарата сульфонилмочевины (ПСМ) связь отсутствовала. При увеличении дозы ПСМ на 1 следует
ожидать увеличение ИМТ на 0,019. У всех пациентов регистрировалась дислипидемия: ЛПНП в 1 груп-
пе 3,2±0,4[3,06-3,34], во 2 группе 3,2±0,6 [2,99 -3,41], в 3 группе 3,3±0,7 [3,05-3,55]; холестерин в 1 группе
5,7±1,0 [5,34-6,06], в 2 группе 5,9±0,9 [5,58-6,22], в 3 группе 6,1±0,9 [5,7-6,42]. У всех больных была выявлена
артериальная гипертензия (АГ). Во всех группах диагностировались хроническая болезнь почек (ХБП).
В 1 группе было с ХБП С2А1 5 пациентов (16,7%), 17 больных с ХБП С3а (А1-А2) (56,7%) и 8- ХБП С3б (А1-А2)
(26,7%). Во 2 группе ХБП С2А1 3,3% (n=1), ХБП С3а (А1-А2) 86,7% (n=26), ХБП С3б (А1-А2) 10% (n=3). В 3 группе
ХБПС2А1 40%(n=12), ХБП С3аА1-А2 36,7%(n=11), ХБП С3бА1-А2 23,3% (n=7). Из 90 пациентов со скоростью
клубочковой фильтрации (СКФ) более 50мл/мин/1.73 м2 было 14, а с менее 50 мл/мин/1.73 м2-16 больных.
Чем больше стаж СД2, тем меньше СКФ был. Был проведен анализ для выявления связи между СКФ и дли-
тельности СД2. Исходя из полученных данных при сопоставлении показателя стажа СД более 6 лет и по-
казателя СКФ менее 50 мл/мин/1.73 м2, были установлены статистически значимые различия (p = 0,004,
p < 0,001). Анализ показал, шанс иметь СКФ меньше 50 при наличии СД2 более 6 лет были выше в 37,500 раз,
по сравнению с СД менее 6 лет, различия шансов были статистически значимыми (95% ДИ: 3,638 – 386,513).
HbA1C составил 9,3±1,2 [9,1-9,6]. Корреляционный анализ показал, что при увеличении стажа СД2 на 0,446
следует ожидать увеличение HbA1C на 1. При увеличении HbA1C на 1 следует ожидать увеличение СКФ
на 1,007. При увеличении HbA1C на 1 следует ожидать уменьшение ИМТ на 0,518. При осмотре глазного
дна выявились в 1 группе 80% (n=24) больных с ретинопатией, во 2 группе 80 % (n=24), в 3 группе 66,6 %
(n=20). Всем больным был выставлен диагноз диабетическая полинейропатия.
ВЫВОДЫ: больные с СД2 и передним ОИМ с зубцом Q имели осложнения и заболевания, которые
говорили о наличии и риске значимых сердечно-сосудистых осложнений.
8
Souza, M., X. Hu, and X. Zhang. "AVALIAÇÃO DE UMA NOVA PLATAFORMA DE IMUNOENSAIO RÁPIDO: SUPERFLEX." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial, 64. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.6837.
Повний текст джерелаАнотація:
Objetivo: Avaliar o desempenho clínico do ensaio SuperFlex cTnl (troponina I). Método: Avaliação do sexo específico da imprecisão total (%CV) no percentil 99 de acordo com o CLSI EP05 e o CLSI EP17-A2; calcular a porcentagem de homens e mulheres saudáveis com concentrações de troponina I iguais ou superiores ao LoD de acordo com a Diretriz(1); avaliar a precisão diagnóstica do ensaio cTnl de acordo com o CLSI EP12-A2. Conclusão: O CV% dividido por sexo e p99th foram 7,15% a 27 ng/l (homens; n = 308) e 7,35% a 24 ng/l (mulheres; n = 312). A taxa de detecção de troponina I (cTnI) de todos os indivíduos saudáveis observados do LoD ao 99º foi de 82,57% pelo ensaio SuperFlex cTnI; 89,9% para homens e 75,48% para mulheres. De acordo com a proposta de Apple(2), o teste SuperFlex cTnI pode atender aos requisitos como ensaio de alta sensibilidade de segunda geração. Como marcador de infarto agudo do miocárdio (IAM), cTnI tem alta sensibilidade diagnóstica, principalmente na fase inicial da dor torácica. O SuperFlex™ (PerkinElmer®) é um sistema totalmente automatizado, que combina tecnologia de quimioluminescência com partículas imunomagnéticas, resultando em curto tempo de resposta (TAT), maior sensibilidade e especificidade. Para encurtar o TAT, sangue total no tubo primário pode ser testado imediatamente. Além disso, o SuperFlex™ possui vários outros ensaios como dímero D, NT-proBNP, procalcitonina e CK-MB, além de outros com resultados entre 5 e 15 minutos. Referências: 1. Apple FS, Fantz CR, Collinson PO; IFCC Committee on Clinical Application of Cardiac Bio-Markers. Implementation of high-sensitivity and point-of-care cardiac troponin assays into practice: some different thoughts. Clin Chem. 2021; 67(1): 70-8. 2. Apple FS, Sandoval Y, Jaffe AS, et al. Cardiac troponin assays: guide to understanding analytical characteristics and their impact on clinical care. Clin Chem 2017; 63: 73-81.
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Fulantelli, Giovanni, Lidia Scifo, and Davide Taibi. "THE ECOLOGICAL SYSTEMS THEORY OF HUMAN DEVELOPMENT TO EXPLORE THE STUDENT-SOCIAL MEDIA INTERACTION." In eLSE 2021. ADL Romania, 2021. http://dx.doi.org/10.12753/2066-026x-21-019.
Повний текст джерелаАнотація:
According to the Bronfenbrenner's ecological systems theory of human development ([1][2][3][4][5]), the development of each individual cannot be observed without considering its relationship with the development of other people and, above all, with the environment in which they live. The ecological orientation of Bronfenbrenner with respect to human development is therefore based on the interest in the progressive adaptation between an active organism that grows and its immediate environment: the individual-environment interaction that is determined by the relationships existing between the different environmental situations and the individuals present in that context is fundamental. Consequently, the ecological environment that is considered relevant to development processes is not limited to a single environmental situation but includes the interconnections between multiple environmental situations and the different influences of each individual. The evolution of the Internet-based technologies has brought to the development of solutions that have profoundly changed the way we live, including education. The advent of social media and social networks represents a milestone in the history of Internet, opening up to profound reflections on the "virtualization" of relationships, their growing importance in everyday life, and their role in education. Many authors argue that the Internet and the social media should no longer be considered as a tool to connect to a virtual reality that is separate from the real world, but as a place in which users live daily ([6][9][11][10]); consequently, they constitute one of the environmental situations mentioned by Bronfenbrenner. However, the risks deriving from the use of social media have been widely discusses in the literature ([7][8][12]). Adolescents are more exposed to the social media threats, since they are unable to perceive the profoundly different dynamics that govern offline and online networks. In this paper, having in mind the Bronfenbrenner's ecological systems theory of human development, we argue that the progressive adaptation of students to social media should be considered as a process of their growth and development. Furthermore, we analyze some corrections to be introduced in the educational paths of adolescents necessary to reduce the threats deriving from the use of social media and social networks in education. Reference Text and Citations [1] Bronfenbrenner, U. (1961). Toward a theoretical model for the analysis of parent-child relationships in a social context. In J. C. Glidewell (Ed.), Parental attitudes and child behavior (pp. 90-109). Springfield, IL: Charles C. Thomas. [2] Bronfenbrenner, U. (1973). Social ecology of human development. In F. Richardson (Ed.), Brain and intelligence: The ecology of child development (pp. 113-129). Hyattsville, MD: National Education Press. [3] Bronfenbrenner, U. (1974). Developmental research, public policy, and the ecology of childhood. Child Development, 45, 1-5. https://doi.org/10.2307/1127743 [4] Bronfenbrenner, U. (1994). Ecological models of human development. In T. Husen & T. N. Postlethwaite (Eds.), International encyclopedia of education (2nd ed., Vol. 3, pp. 1643-1647). Oxford, UK: Pergamon Press and Elsevier Science. [5] Bronfenbrenner, U., & Morris, P. A. (2006). The bioecological model of human development. In W. Damon (Series Ed.) & R. M. Lerner (Vol. Ed.), Handbook of child psychology: Theoretical models of human development (pp. 793-828). New York, NY: Wiley. [6] Carr, N. (2011). The Shallows: What the Internet Is Doing to Our Brains. New York: W.W. Norton & Company. [7] Livingstone, S., Haddon, L., G?rzig, A., & ?lafsson, K. (2011). Risks and safety on the internet: The perspective of European children. Full Findings. London: EU Kids Online, LSE. [Google Scholar] [8] Martin, F., Wang, C., Petty, T., Wang, W., & Wilkins, P. (2018). Middle school students' social media use. Journal of Educational Technology & Society, 21(1), 213-224. https://www.jstor.org/stable/26273881 [9] Musetti, A., Cattivelli, R., Giacobbi, M., Zuglian, P., Ceccarini, M., Capelli, F., et al. (2016). Challenges in internet addiction disorder: is a diagnosis feasible or not? Frontiers in Psychology, 7. doi: 10.3389/fpsyg.2016.00842 [10] Musetti, A., Cattivelli, R., Zuglian, P., Terrone, G., Pozzoli, S., Capelli, F., et al. (2017). Internet addiction disorder o internet related psychopathology? [Internet Addiction disorder or Internet Related Psychopathology?]. Giornale Italiano di Psicologia, 44, 359-382. doi: 10.1421/87345 [11] Taymur, I., Budak, E., Demirci, H., Akdag, H.A., Gungor, B.B., & Ozdel, K. (2016). A study of the relationship between internet addiction, psychopathology and dysfunctional beliefs. Computers in Human Behavior,61, 532-536. https://doi.org/10.1016/j.chb.2016.03.043 [12] Willoughby, M. (2018). A review of the risks associated with children and young people's social media use and the implications for social work practice. Journal of Social Work Practice,33(2), 127-140. https://doi.org/10.1080/02650533.2018.1460587
Звіти організацій з теми "631.382 8"
1
Chou, Roger, Jesse Wagner, Azrah Y. Ahmed, Benjamin J. Morasco, Devan Kansagara, Shelley Selph, Rebecca Holmes, and Rongwei Fu. Living Systematic Review on Cannabis and Other Plant-Based Treatments for iii Chronic Pain: 2022 Update. Agency for Healthcare Research and Quality (AHRQ), September 2022. http://dx.doi.org/10.23970/ahrqepccer250update2022.
Повний текст джерелаАнотація:
Objectives. To update the evidence on benefits and harms of cannabinoids and similar plant-based compounds to treat chronic pain using a living systematic review approach. Data sources. Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Library, and SCOPUS® databases; reference lists of included studies; and submissions received after Federal Register request were searched to April 4, 2022. Review methods. Using dual review, we screened search results for randomized controlled trials (RCTs) and observational studies of patients with chronic pain evaluating cannabis, kratom, and similar compounds with any comparison group and at least 1 month of treatment or followup. Dual review was used to abstract study data, assess study-level risk of bias, and rate the strength of evidence (SOE). Prioritized outcomes included pain, overall function, and adverse events. We grouped studies that assessed tetrahydrocannabinol (THC) and/or cannabidiol (CBD) based on their THC to CBD ratio and categorized them as comparable THC to CBD ratio, high-THC to CBD ratio, and low-THC to CBD ratio. We also grouped studies by whether the product was a whole-plant product (cannabis), cannabinoids extracted or purified from a whole plant, or a synthetic product. We conducted meta-analyses using the profile likelihood random effects model and assessed between-study heterogeneity using Cochran’s Q statistic chi square test and the I2 statistic. Magnitude of benefit was categorized as no effect or small, moderate, and large effects. Results. From 3,283 abstracts, 21 RCTs (N=1,905) and 8 observational studies (N=13,769) assessing different cannabinoids were included; none evaluated kratom. Studies were primarily short term, and 59 percent enrolled patients with neuropathic pain. Comparators were primarily placebo or usual care. The SOE was low unless otherwise noted. Compared with placebo, comparable THC to CBD ratio oral spray was associated with a small benefit in change in pain severity (7 RCTs, N=632, 0 to10 scale, mean difference [MD] −0.54, 95% confidence interval [CI] −0.95 to −0.19, I2=39%; SOE: moderate) and overall function (6 RCTs, N=616, 0 to 10 scale, MD −0.42, 95% CI −0.73 to −0.16, I2=32%). There was no effect on study withdrawals due to adverse events. There was a large increased risk of dizziness and sedation, and a moderate increased risk of nausea (dizziness: 6 RCTs, N=866, 31.0% vs. 8.0%, relative risk [RR] 3.57, 95% CI 2.42 to 5.60, I2=0%; sedation: 6 RCTs, N=866, 8.0% vs. 1.2%, RR 5.04, 95% CI 2.10 to 11.89, I2=0%; and nausea: 6 RCTs, N=866, 13% vs. 7.5%, RR 1.79, 95% CI 1.19 to 2.77, I2=0%). Synthetic products with high-THC to CBD ratios were associated with a moderate improvement in pain severity, a moderate increase in sedation, and a large increase in nausea (pain: 6 RCTs, N=390, 0 to 10 scale, MD −1.15, 95% CI −1.99 to −0.54, I2=48%; sedation: 3 RCTs, N=335, 19% vs. 10%, RR 1.73, 95% CI 1.03 to 4.63, I2=28%; nausea: 2 RCTs, N=302, 12.3% vs. 6.1%, RR 2.19, 95% CI 0.77 to 5.39; I²=0%). We also found moderate SOE for a large increased risk of dizziness (2 RCTs, 32% vs. 11%, RR 2.74, 95% CI 1.47 to 6.86, I2=40%). Extracted whole-plant products with high-THC to CBD ratios (oral) were associated with a large increased risk of study withdrawal due to adverse events (1 RCT, 13.9% vs. 5.7%, RR 3.12, 95% CI 1.54 to 6.33) and dizziness (1 RCT, 62.2% vs. 7.5%, RR 8.34, 95% CI 4.53 to 15.34); outcomes assessing benefit were not reported or insufficient. We observed a moderate improvement in pain severity when combining all studies of high-THC to CBD ratio (8 RCTs, N=684, MD −1.25, 95% CI −2.09 to −0.71, I2=58%; SOE: moderate). Evidence (including observational studies) on whole-plant cannabis, topical or oral CBD, low-THC to CBD, other cannabinoids, comparisons with active products or between cannabis-related products, and impact on use of opioids was insufficient to draw conclusions. Other important harms (psychosis, cannabis use disorder, and cognitive effects) were not reported. Conclusions. Low to moderate strength evidence suggests small to moderate improvements in pain (mostly neuropathic), and moderate to large increases in common adverse events (dizziness, sedation, nausea) with high- and comparable THC to CBD ratio extracted cannabinoids and synthetic products during short-term treatment (1 to 6 months); high-THC to CBD ratio products were also associated with increased risk of withdrawal due to adverse events. Evidence for whole-plant cannabis and other comparisons, outcomes, and plant-based compounds was unavailable or insufficient to draw conclusions. Small sample sizes, lack of evidence for moderate and long-term use and other key outcomes, such as other adverse events and impact on use of opioids during treatment, indicate that more research is needed.
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Pavlovic, Noel, Barbara Plampin, Gayle Tonkovich, and David Hamilla. Special flora and vegetation of Indiana Dunes National Park. National Park Service, 2024. http://dx.doi.org/10.36967/2302417.
Повний текст джерелаАнотація:
The Indiana Dunes (comprised of 15 geographic units (see Figure 1) which include Indiana Dunes National Park, Dunes State Park, and adjacent Shirley Heinze Land Trust properties) are remarkable in the Midwest and Great Lakes region for the vascular plant diversity, with an astounding 1,212 native plant species in an area of approximately 16,000 acres! This high plant diversity is the result of the interactions among postglacial migrations, the variety of soil substrates, moisture conditions, topography, successional gradients, ?re regimes, proximity to Lake Michigan, and light levels. This richness is all the more signi?cant given the past human alterations of the landscape resulting from logging; conversion to agriculture; construction of transportation corridors, industrial sites, and residential communities; ?re suppression; land abandonment; and exotic species invasions. Despite these impacts, multiple natural areas supporting native vegetation persist. Thus, each of the 15 units of the Indiana Dunes presents up to eight subunits varying in human disturbance and consequently in ?oristic richness. Of the most signi?cant units of the park in terms of number of native species, Cowles Dunes and the Dunes State Park stand out from all the other units, with 786 and 686 native species, respectively. The next highest ranked units for numbers of native species include Keiser (630), Furnessville (574), Miller Woods (551), and Hoosier Prairie (542). The unit with lowest plant richness is Heron Rookery (220), with increasing richness in progression from Calumet Prairie (320), Hobart Prairie Grove (368), to Pinhook Bog (380). Signi?cant natural areas, retaining native vegetation composition and structure, include Cowles Bog (Cowles Dunes Unit), Howes Prairie (Cowles Dunes), Dunes Nature Preserve (Dunes State Park), Dunes Prairie Nature Preserve (Dunes State Park), Pinhook Bog, Furnessville Woods (Furnessville), Miller Woods, Inland Marsh, and Mnoke Prairie (Bailly). Wilhelm (1990) recorded a total of 1,131 native plant species for the ?ora of the Indiana Dunes. This was similar to the 1,132 species recorded by the National Park Service (2014) for the Indiana Dunes. Based on the nomenclature of Swink and Wilhelm (1994), Indiana Dunes National Park has 1,206 native plant species. If we include native varieties and hybrids, the total increases to 1,244 taxa. Based on the nomenclature used for this report?the Flora of North America (FNA 2022), and the Integrated Taxonomic Information System (ITIS 2022)?Indiana Dunes National Park houses 1,206 native vascular plant species. As of this writing (2020), the Indiana Dunes is home to 37% of the species of conservation concern in Indiana (241 out of 624 Indiana-listed species): state extirpated = 10 species, state endangered = 75, and state threatened = 100. Thus, 4% of the state-listed species in the Indiana Dunes are extirpated, 31% endangered, and 41% threatened. Watch list and rare categories have been eliminated. Twenty-nine species once documented from the Indiana Dunes may be extirpated because they have not been seen since 2001. Eleven have not been seen since 1930 and 15 since 1978. If we exclude these species, then there would be a total of 1,183 species native to the Indiana Dunes. Many of these are cryptic in their life history or diminutive, and thus are di?cult to ?nd. Looking at the growth form of native plants, <1% (nine species) are clubmosses, 3% (37) are ferns, 8% (297) are grasses and sedges, 56% (682) are forbs or herbs, 1% (16) are herbaceous vines, <1% (7) are subshrubs (woody plants of herbaceous stature), 5% (60) are shrubs, 1% (11) are lianas (woody vines), and 8% (93) are trees. Of the 332 exotic species (species introduced from outside North America), 65% (219 species) are forbs such as garlic mustard (Alliaria petiolata), 15% (50 species) are graminoids such as phragmites (Phragmites australis ssp. australis), 2% (seven species) are vines such as ?eld bindweed (Convulvulus arvensis), <1% (two species) are subshrubs such as Japanese pachysandra (Pachysandra terminalis), 8% (28 species) are shrubs such as Asian bush honeysuckle (Lonicera spp.), 1% (three species) are lianas such as oriental bittersweet (Celastrus orbiculatus), and 8% (23 species) are trees such as tree of heaven (Ailanthus altissimus). Of the 85 adventive species, native species that have invaded from elsewhere in North America, 14% (11 species) are graminoids such as broom sedge (Andropogon virginicus), 57% (48 species) are forbs such as fall phlox (Phlox paniculata), 5% (six species) are shrubs such as Carolina allspice (Calycanthus floridus), 3% (two species) are subshrubs such as holly leaved barberry (Berberis repens), 1% (one species) is a liana (trumpet creeper (Campsis radicans), 3% two species) are herbaceous vines such as tall morning glory (Ipomoea purpurea), and 17% (15 species) are trees such as American holly (Ilex opaca). A total of 436 species were found to be ?special? based on political rankings (federal and state-listed threatened and endangered species), species with charismatic ?owers, and those that are locally rare.
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Chou, Roger, Azrah Y. Ahmed, Christina Bougatsos, Benjamin J. Morasco, Rebecca Holmes, Terran Gilbreath, and Rongwei Fu. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2022 Update—Surveillance Report 2. Agency for Healthcare Research and Quality (AHRQ), January 2023. http://dx.doi.org/10.23970/ahrqepccer250.2022updatesr2.
Повний текст джерелаАнотація:
Objectives. To update the evidence on benefits and harms of cannabinoids and similar plant-based compounds to treat chronic pain using a living systematic review approach. Data sources. Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Library, and SCOPUS® databases; reference lists of included studies; and submissions received after Federal Register request were searched to October 24, 2022. Review methods. Using dual review, we screened search results for randomized controlled trials (RCTs) and observational studies of patients with chronic pain evaluating cannabis, kratom, and similar compounds with any comparison group and at least 1 month of treatment or followup. Dual review was used to abstract study data, assess study-level risk of bias, and rate the strength of evidence (SOE). Prioritized outcomes included pain, overall function, and adverse events. We grouped studies that assessed tetrahydrocannabinol (THC) and/or cannabidiol (CBD) based on their THC to CBD ratio and categorized them as comparable THC to CBD ratio, high-THC to CBD ratio, and low-THC to CBD ratio. We also grouped studies by whether the product was a whole-plant product (cannabis), cannabinoids extracted or purified from a whole plant, or a synthetic product. We conducted meta-analyses using the profile likelihood random effects model and assessed between-study heterogeneity using Cochran’s Q statistic chi square test and the I2 statistic. Magnitude of benefit was categorized as no effect or small, moderate, and large effects. Results. From a total of 3,568 abstracts, 21 RCTs (N=1,905) and 9 observational studies (N=15,079) assessing different cannabinoids were included; none evaluated kratom. Studies were primarily short term, and 60 percent enrolled patients with neuropathic pain. Comparators were primarily placebo or usual care. The SOE was low unless otherwise noted. Compared with placebo, comparable THC to CBD ratio oral spray was associated with a small benefit in pain severity (7 RCTs, N=632, 0 to 10 scale, mean difference [MD] −0.54, 95% confidence interval [CI] −0.95 to −0.19, I2=39%; SOE: moderate) and overall function (6 RCTs, N=616, 0 to 10 scale, MD −0.42, 95% CI −0.73 to −0.16, I2=32%). There was no effect on study withdrawals due to adverse events. There was a large increased risk of dizziness and sedation, and a moderate increased risk of nausea (dizziness: 6 RCTs, N=866, 31.0% vs. 8.0%, relative risk [RR] 3.57, 95% CI 2.42 to 5.60, I2=0%; sedation: 6 RCTs, N=866, 8.0% vs. 1.2%, RR 5.04, 95% CI 2.10 to 11.89, I2=0%; and nausea: 6 RCTs, N=866, 13% vs. 7.5%, RR 1.79, 95% CI 1.19 to 2.77, I2=0%). Synthetic products with high-THC to CBD ratios were associated with a moderate improvement in pain severity, a moderate increase in sedation, and a large increase in nausea (pain: 6 RCTs, N=390, 0 to 10 scale, MD −1.15, 95% CI −1.99 to −0.54, I2=48%; sedation: 3 RCTs, N=335, 19% vs. 10%, RR 1.73, 95% CI 1.03 to 4.63, I2=28%; nausea: 2 RCTs, N=302, 12.3% vs. 6.1%, RR 2.19, 95% CI 0.77 to 5.39; I²=0%). We also found moderate SOE for a large increased risk of dizziness (2 RCTs, 32% vs. 11%, RR 2.74, 95% CI 1.47 to 6.86, I2=40%). Extracted whole-plant products with high-THC to CBD ratios (oral) were associated with a large increased risk of study withdrawal due to adverse events (1 RCT, 13.9% vs. 5.7%, RR 3.12, 95% CI 1.54 to 6.33) and dizziness (1 RCT, 62.2% vs. 7.5%, RR 8.34, 95% CI 4.53 to 15.34); outcomes assessing benefit were not reported or insufficient. We observed a moderate improvement in pain severity when combining all studies of high-THC to CBD ratio (8 RCTs, N=684, MD −1.25, 95% CI −2.09 to −0.71, I2=58%; SOE: moderate). Evidence (including observational studies) on whole-plant cannabis, topical or oral CBD, low-THC to CBD, other cannabinoids, comparisons with active products or between cannabis-related products, and impact on use of opioids was insufficient to draw conclusions. Other important harms (psychosis, cannabis use disorder, and cognitive effects) were not reported. Conclusions. Low to moderate strength evidence suggests small to moderate improvements in pain (mostly neuropathic), and moderate to large increases in common adverse events (dizziness, sedation, nausea) with high and comparable THC to CBD ratio extracted cannabinoids and synthetic products during short-term treatment (1 to 6 months); high-THC to CBD ratio products were also associated with increased risk of withdrawal due to adverse events. Evidence for whole-plant cannabis and other comparisons, outcomes, and plant-based compounds was unavailable or insufficient to draw conclusions. Small sample sizes, lack of evidence for moderate and long-term use and other key outcomes, such as other adverse events and impact on use of opioids during treatment, indicate that more research is needed.
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McDonagh, Marian S., Jesse Wagner, Azrah Y. Ahmed, Rongwei Fu, Benjamin Morasco, Devan Kansagara, and Roger Chou. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain. Agency for Healthcare Research and Quality (AHRQ), October 2021. http://dx.doi.org/10.23970/ahrqepccer250.
Повний текст джерелаАнотація:
Objectives. To evaluate the evidence on benefits and harms of cannabinoids and similar plant-based compounds to treat chronic pain. Data sources. Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Library, and SCOPUS® databases, reference lists of included studies, submissions received after Federal Register request were searched to July 2021. Review methods. Using dual review, we screened search results for randomized controlled trials (RCTs) and observational studies of patients with chronic pain evaluating cannabis, kratom, and similar compounds with any comparison group and at least 1 month of treatment or followup. Dual review was used to abstract study data, assess study-level risk of bias, and rate the strength of evidence. Prioritized outcomes included pain, overall function, and adverse events. We grouped studies that assessed tetrahydrocannabinol (THC) and/or cannabidiol (CBD) based on their THC to CBD ratio and categorized them as high-THC to CBD ratio, comparable THC to CBD ratio, and low-THC to CBD ratio. We also grouped studies by whether the product was a whole-plant product (cannabis), cannabinoids extracted or purified from a whole plant, or synthetic. We conducted meta-analyses using the profile likelihood random effects model and assessed between-study heterogeneity using Cochran’s Q statistic chi square and the I2 test for inconsistency. Magnitude of benefit was categorized into no effect or small, moderate, and large effects. Results. From 2,850 abstracts, 20 RCTs (N=1,776) and 7 observational studies (N=13,095) assessing different cannabinoids were included; none of kratom. Studies were primarily short term, and 75 percent enrolled patients with a variety of neuropathic pain. Comparators were primarily placebo or usual care. The strength of evidence (SOE) was low, unless otherwise noted. Compared with placebo, comparable THC to CBD ratio oral spray was associated with a small benefit in change in pain severity (7 RCTs, N=632, 0 to10 scale, mean difference [MD] −0.54, 95% confidence interval [CI] −0.95 to −0.19, I2=28%; SOE: moderate) and overall function (6 RCTs, N=616, 0 to 10 scale, MD −0.42, 95% CI −0.73 to −0.16, I2=24%). There was no effect on study withdrawals due to adverse events. There was a large increased risk of dizziness and sedation and a moderate increased risk of nausea (dizziness: 6 RCTs, N=866, 30% vs. 8%, relative risk [RR] 3.57, 95% CI 2.42 to 5.60, I2=0%; sedation: 6 RCTs, N=866, 22% vs. 16%, RR 5.04, 95% CI 2.10 to 11.89, I2=0%; and nausea: 6 RCTs, N=866, 13% vs. 7.5%, RR 1.79, 95% CI 1.20 to 2.78, I2=0%). Synthetic products with high-THC to CBD ratios were associated with a moderate improvement in pain severity, a moderate increase in sedation, and a large increase in nausea (pain: 6 RCTs, N=390 to 10 scale, MD −1.15, 95% CI −1.99 to −0.54, I2=39%; sedation: 3 RCTs, N=335, 19% vs. 10%, RR 1.73, 95% CI 1.03 to 4.63, I2=0%; nausea: 2 RCTs, N=302, 12% vs. 6%, RR 2.19, 95% CI 0.77 to 5.39; I²=0%). We found moderate SOE for a large increased risk of dizziness (2 RCTs, 32% vs. 11%, RR 2.74, 95% CI 1.47 to 6.86, I2=0%). Extracted whole-plant products with high-THC to CBD ratios (oral) were associated with a large increased risk of study withdrawal due to adverse events (1 RCT, 13.9% vs. 5.7%, RR 3.12, 95% CI 1.54 to 6.33) and dizziness (1 RCT, 62.2% vs. 7.5%, RR 8.34, 95% CI 4.53 to 15.34). We observed a moderate improvement in pain severity when combining all studies of high-THC to CBD ratio (8 RCTs, N=684, MD −1.25, 95% CI −2.09 to −0.71, I2=50%; SOE: moderate). Evidence on whole-plant cannabis, topical CBD, low-THC to CBD, other cannabinoids, comparisons with active products, and impact on use of opioids was insufficient to draw conclusions. Other important harms (psychosis, cannabis use disorder, and cognitive effects) were not reported. Conclusions. Low to moderate strength evidence suggests small to moderate improvements in pain (mostly neuropathic), and moderate to large increases in common adverse events (dizziness, sedation, nausea) and study withdrawal due to adverse events with high- and comparable THC to CBD ratio extracted cannabinoids and synthetic products in short-term treatment (1 to 6 months). Evidence for whole-plant cannabis, and other comparisons, outcomes, and PBCs were unavailable or insufficient to draw conclusions. Small sample sizes, lack of evidence for moderate and long-term use and other key outcomes, such as other adverse events and impact on use of opioids during treatment, indicate that more research is needed.
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Chou, Roger, Azrah Y. Ahmed, Benjamin J. Morasco, Christina Bougatsos, Tracy Dana, Rongwei Fu, and Terran Gilbreath. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2023 Update. Agency for Healthcare Research and Quality, August 2023. http://dx.doi.org/10.23970/ahrqepccer250update2023.
Повний текст джерелаАнотація:
Objectives. To update the evidence on benefits and harms of cannabinoids and other plant-based compounds to treat sub-acute and chronic pain in adults and adolescents using a living systematic review approach. Data sources. Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Library, and SCOPUS® databases; and reference lists of included studies were searched to April 23, 2023. Review methods. An updated protocol with expanded inclusion criteria (addition of sub-acute [4 to 12 weeks’ duration] pain and adolescents) was posted on the PROSPERO registry. We grouped studies based on their THC to CBD ratio and by product type, i.e. whole-plant (extracted or purified), or synthetic. We conducted random effects meta-analyses and categorized magnitude of benefit (large, moderate, small, or no effect [less than small]). Results. Two new RCTs (n=115 and 15) and two new observational studies (N=2,071) were added for this annual update; no study addressed subacute pain or adolescents. One new RCT compared high and low THC to CBD ratio products versus placebo; the other new RCT evaluated was very small and had methodological limitations. Since the inception of this living review, from 5,228 total abstracts identified, 23 RCTs (N=2,035) and 10 observational studies (N=15,840) assessing different cannabinoids were included; no study evaluated kratom. Studies were primarily short term, and 58 percent enrolled patients with neuropathic pain. Comparators were primarily placebo or usual care. Strength of evidence was low, unless indicated otherwise. Compared with placebo, plant-extracted, comparable ratio THC to CBD oral spray was associated with a small decrease in pain severity (7 RCTs, N=632, 0 to 10 scale, mean difference [MD] −0.54, 95% confidence interval [CI] −0.95 to −0.19, I2=39%; SOE: moderate) and overall function (6 RCTs, N=616, 0 to 10 scale, MD −0.42, 95% CI −0.73 to −0.16, I2=32%; SOE: moderate) versus placebo. There was no effect on study withdrawals due to adverse events. There was a large increased risk of dizziness and sedation, and a moderate increased risk of nausea (dizziness: 6 RCTs, N=866, 31.0% vs. 8.0%, relative risk [RR] 3.57, 95% CI 2.42 to 5.60, I2=0%; sedation: 6 RCTs, N=866, 8.0% vs. 1.2%, RR 5.04, 95% CI 2.10 to 11.89, I2=0%; and nausea: 6 RCTs, N=866, 13% vs. 7.5%, RR 1.79, 95% CI 1.19 to 2.77, I2=0%). Synthetic high-THC to CBD ratio products were associated with a small improvement in pain severity, a moderate increase in sedation, and a large increase in risk of nausea following the addition of one new RCT (pain: 7 RCTs, N=448, 0 to 10 scale, MD −0.95, 95% CI −1.81 to −0.25, I2=60%; sedation: 4 RCTs, N=386, 19% vs. 12%, RR 1.60, 95% CI 1.01 to 2.95, I2=8%; nausea: 3 RCTs, N=353, 11.1% vs. 5.2%, RR 2.22, 95% CI 0.90 to 5.05; I²=0%). There was also moderate SOE for a large increased risk of dizziness (3 RCTs, N=353, 29% vs. 11%, RR 2.52, 95% CI 1.20 to 4.82, I2=41%). Extracted whole-plant high-THC to CBD ratio products (oral) were associated with a large increased risk of study withdrawal due to adverse events (1 RCT, viii 13.9% vs. 5.7%, RR 3.12, 95% CI 1.54 to 6.33) and dizziness (1 RCT, 62.2% vs. 7.5%, RR 8.34, 95% CI 4.53 to 15.34); outcomes assessing benefit were not reported or insufficient. Evidence (including observational studies) on whole-plant cannabis, topical or oral CBD, low-THC to CBD products (2 new RCTs), other cannabinoids, comparisons with active non-cannabis treatments or between cannabis-related products, and impact on use of opioids also remained insufficient. Evidence was not available on important harms such as psychosis, cannabis use disorder, and cognitive effects. Conclusions. Low to moderate strength evidence suggests small improvements in pain (mostly neuropathic), and moderate to large increases in common adverse events (dizziness, sedation, nausea) with high and comparable THC to CBD ratio extracted cannabinoids and synthetic products versus placebo during short-term treatment (1 to 6 months) in adults with chronic pain. Evidence for low-THC to CBD ratio products, whole-plant cannabis, and other comparisons, outcomes, and plant-based compounds was unavailable or insufficient to draw conclusions.
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Vitrinite reflectance data of cuttings (630-9,550') and of core (8,319-8,888') from the Texaco Inc. Wolfbutton 32-7-8 well. Alaska Division of Geological & Geophysical Surveys, 1992. http://dx.doi.org/10.14509/19041.
Повний текст джерела