Добірка наукової літератури з теми "628.166 : 628.161.2"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "628.166 : 628.161.2".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "628.166 : 628.161.2"
1
Buckingham, David. "Optical Properties: Modern Nonlinear Optics . Myron Evans and Stanisław Kielich, Eds. Wiley, New York, 1994. In three parts. Part 1, xii, 628 pp., illus. $150 or £124. Part 2, xii, 835 pp., illus. $195 or £161. Part 3, xiv, 823 pp., illus. $195 or £161. Advances in Chemical Physics, vol. 85." Science 266, no. 5185 (October 28, 1994): 665. http://dx.doi.org/10.1126/science.266.5185.665-a.
Повний текст джерела
2
Buckingham, David. "Optical Properties: Modern Nonlinear Optics . Myron Evans and Stanisław Kielich, Eds. Wiley, New York, 1994. In three parts. Part 1, xii, 628 pp., illus. $150 or £124. Part 2, xii, 835 pp., illus. $195 or £161. Part 3, xiv, 823 pp., illus. $195 or £161. Advances in Chemical Physics, vol. 85." Science 266, no. 5185 (October 28, 1994): 665. http://dx.doi.org/10.1126/science.266.5185.665.a.
Повний текст джерела
3
Jo, Hyung Ho, Young Ok Yoon, Jin Kyu Lee, and Shae K. Kim. "Effect of Partial Remelting Procedure on the Microstructural Evolution of 7075 Al Wrought Alloy for Thixoextrusion." Solid State Phenomena 116-117 (October 2006): 336–39. http://dx.doi.org/10.4028/www.scientific.net/ssp.116-117.336.
Повний текст джерелаАнотація:
The feasibility study for thixoextrusion of 7075 Al wrought alloys was carried out with respect to reheating profile, isothermal holding temperature and time during the partial remelting through simple partial remelting. The reheating rates were 40/min and 60/min. The isothermal holding temperatures were controlled at 609, 622, 628 and 632 for 0, 2, 5, 10 and 30 min. The interesting point of this study was that the thixotropic structures of 7075 Al wrought alloy without additional pretreatment could be obtained through simple partial remelting. The average grain size was significantly smaller in the quickly heated specimen. The liquid fraction was increased with increasing isothermal holding temperature and time while the average grain size was inversely proportional to isothermal holding temperature and time. However, there was no big change of liquid fraction and average grain size with respect to isothermal holding time. The important fact that the liquid fraction and average grain size were almost uniform after 5 min is considered very useful for thixoextrusion in terms of actual extrusion time.
4
KOOS, ROBERT D., and WILLIAM J. LEMAIRE. "The Effects of a Gonadotropin-Releasing Hormone Agonist on Ovulation and Steroidogenesis during Perfusion of Rabbit and Rat Ovariesin vitro*." Endocrinology 116, no. 2 (February 1985): 628–32. http://dx.doi.org/10.1210/endo-116-2-628.
Повний текст джерела
5
Gschwandtner, Minar, Ahmadi, Haumer, Hülsmann, Maca, Schnürer, et al. "Therapeutische Alternativen in der Behandlung schwerer Beinischämien: Erfahrungen bei 190 Patienten an einer Klinischen Abteilung für Angiologie." Vasa 28, no. 4 (November 1, 1999): 271–78. http://dx.doi.org/10.1024/0301-1526.28.4.271.
Повний текст джерелаАнотація:
Background: Different therapies in consecutive patients (1987–1992) with chronic critical limb ischemia at a department of medical angiology, their short- and long-term outcome were investigated. Patients and methods: 190 patients (112 males, 78 females; age: 67 ± 12 years); 78 in grade II, 112 in grade III according to Rutherford’s classification. Therapeutic regimen: 1. vascular recanalisation by percutaneous transluminal angioplasty [PTA], local or systemic lysis; 2. surgical vascular reconstruction in case of impossibility or failure of catheter procedures; 3. prostanoids and/or antibiotics; 4. local wound treatment including amputations. Results: Vascular recanalisation was attempted in 156/190 (82.1%): PTA in 116/190, surgical vascular reconstruction in 50/190, local in 24/190 and systemic lysis in 8/190 patients. Prostanoids were applied in 89/190 and antibiotics in 73/190 patients. At the time of dismissal 164/190 (86.3%) patients were clinically improved; 11/190 (5.8%) unchanged, 13/190 (6.8%) had undergone major amputations and 2/190 (1.1%) had died. After 2,6 ± 2,2 years 77 of the 141 patients, who were still alive, were reexamined. Among these 77 patients 84.4% were in grade 0 or I, 15.6% in chronic critical limb ischemia. Furthermore 13.0% had been amputated since dismissal. Forty-nine of 190 (25.8%) patients had died 3,2 ± 1,9 years after dismissal from hospital. Conclusion: Catheter techniques, mostly PTA, is possible in the majority of patients with chronic critical limb ischemia. Cooperation with vascular surgeons in case of technical impossibility or failure of catheter recanalisation is mandatory. Such a regimen yields satisfactory short- and long-term results and a low rate of complications.
6
Salcedo, Irma. "Gerencia, una paradoja epistemológica." Revista de Ciencias Sociales 24, no. 3 (October 1, 2018): 130–32. http://dx.doi.org/10.31876/rcs.v24i3.24932.
Повний текст джерела
7
Shimomura, Yoshimitsu, Masahiko Hara, Takaaki Konuma, Hidehiro Itonaga, Kazuteru Ohashi, Yukiyasu Ozawa, Tetsuya Eto, et al. "Allogeneic Hematopoietic Stem Cell Transplantation for the Treatment of Myelodysplastic Syndrome in Adolescent and Young Adult Patients." Blood 132, Supplement 1 (November 29, 2018): 3452. http://dx.doi.org/10.1182/blood-2018-99-113275.
Повний текст джерелаАнотація:
Abstract nts Introduction Myelodysplastic syndrome (MDS) is clinically and biologically heterogeneous. Although the pathobiology of MDS is complex and not fully understood, the development of MDS involves a series of genetic changes, which influence hematopoietic growth and differentiation, resulting in the accumulation of abnormal cells and the impairment of normal hematopoiesis. Recently, Lindsley et al. reported the difference in the mutation of MDS genes in adolescent and young adult (AYA) patients and elder patients. These results suggested that MDS in AYA patients was biologically different from MDS in elderly patients. In addition, AYA patients have some specific issues such as infertility, late complications, and psychological and social problems. For AYA patients with MDS, similar to MDS patients of other age, allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable treatment option. However, limited evidence was available indicating the effectiveness of allogeneic HSCT in the treatment of MDS in AYA patients, because about 90% of patients noted are usually in an older age group. Thus, we aimed to investigate the epidemiology of AYA patients with MDS who received allogeneic HSCT for the first time, and estimate prognostic factors after HSCT, using registry data of Japanese Data Center for Hematopoietic Cell Transplantation (JDCHCT). Methods We enrolled AYA patients aged 16-39 years from JDCHCT, who received allogeneic HSCT for the first time between January 2000 and December 2015. Active disease was defined as the presence of >5% blast in bone marrow and/or presence of blast in peripheral blood. We set the primary endpoint as the 5-year overall survival (5yOS). Five-year cumulative incidence of relapse (5yCIR) and 5-year cumulative incidence of non-relapse mortality (5yCINRM) were also evaluated as secondary endpoints. OS was evaluated using the log-rank test. Other endpoints were evaluated using Gray's method. To evaluate the prognostic factor for 5yOS, we employed the multivariable Cox proportional hazards model. Covariates were as follows: age (16-29 vs 30-39), sex (male vs female), Performance Status (PS) according to the Eastern Cooperative Oncology Group (0-1 vs 2-4), disease status (active vs non-active), karyotype risk according to the International Prognostic Scoring System (IPSS, good vs intermediate vs poor), conditioning regimen (Reduced intensity conditioning regimen [RIC] vs myeloablative conditioning regimen), donor type (related bone marrow transplantation [BMT] or peripheral blood stem cell transplantation [PBSCT] vs unrelated BMT or PBSCT vs cord blood transplantation [CBT]), prophylaxis of graft-versus-host disease (tacrolimus-based vs cyclosporine A-based), and years of HSCT (2000-2007 vs 2008-2015). Results We analyzed 628 AYA patients with MDS who received HSCT for the first time. Patient characteristics are described in Table 1. Median age was 30 years, 327 patients (52.7%) were of age ≥30 years, and 356 patients (56.7%) were male. At diagnosis, 140 patients (37.4%) were at IPSS low or intermediate-1 risk. At HSCT, 257 (40.9%) patients had active disease and 315 (52.1%), 166 (27.4%), and 124 (20.5%) patients had good, intermediate, and poor risk karyotype, respectively. RIC was administered for 121 (19.9%) patients. Regarding donor type, 230 (36.6%) received related BMT or PBSCT, 297 (47.3%) received unrelated BMT or PBSCT, and 101 (16.1%) received CBT. Regarding primary endpoint, 5yOS after allogeneic HSCT was 69.6% (65.6-73.2%) (Figure A). Five-year CIR and 5yCINRM were 11.9% (9.5-14.7%) and 20.7% (17.4-24.2%), respectively (Figure B, C). Regarding prognostic factors influencing 5yOS, active disease (adjusted hazard ratio [aHR]: 1.54, 95% confidence interval [95%CI]: 1.10-2.17, p-value = 0.013), poor karyotype (aHR: 2.06, 95%CI: 1.38-3.07, p-value < 0.001), PS 2-4 (aHR: 2.03, 95%CI: 1.19-3.48, p-value = 0.013), unrelated BMT or PBSCT (aHR: 2.10, 95%CI: 1.33-3.30, p-value = 0.001) and CBT (aHR: 2.40, 95%CI: 1.46-3.95, p-value < 0.001) were significantly associated with 5yOS, but other factors were not (Table 2). Conclusion In the present study, the epidemiology of AYA patients with MDS who received allogeneic HSCT for the first time, and the prognostic factors influencing 5yOS were evaluated. Our results provide physicians with additional information for the treatment of AYA patients with MDS. Disclosures Mori: Novartis Pharma: Research Funding; Astella Pharma: Honoraria; Shire Japan: Honoraria; Taisho Toyama Pharmaceutical Co: Honoraria; Japan Blood Products Organization: Honoraria; Eisai: Honoraria; Janssen: Honoraria; MSD: Research Funding; SHIONOGI: Honoraria; Pfizer: Honoraria; CHUGAI: Honoraria; Novartis Pharma: Honoraria; MSD: Honoraria; Ono: Honoraria; Celgene: Honoraria; Asahi Kasei: Research Funding; Kyowa Hakko Kirin: Honoraria. Tanaka:Bristol-Myers Squibb: Honoraria, Research Funding; Otsuka: Honoraria; Novartis Pharma: Honoraria; Pfizer: Honoraria. Ishiyama:Alexion Pharmaceuticals, Inc.: Honoraria.
8
Aryanti, Mira. "DETERMINAN BERAT BAYI LAHIR RENDAH (BBLR) DI RSUD INDRAMAYU KABUPATEN INDRAMAYU PROVINSI JAWA BARAT TAHUN 2016." JURNAL KESEHATAN INDRA HUSADA 5, no. 2 (April 18, 2018): 49–57. http://dx.doi.org/10.36973/jkih.v5i2.46.
Повний текст джерелаАнотація:
ABSTRAK
Berdasarkan data dari Dinas Kesehatan Provinsi Jawa Barat tahun 2012 menunjukan bahwa Angka Kematian Bayi (AKB) berjumlah 355 per 1.000 keahiran hidup. (Dinas Kesehatan Provinsi Jawa Barat, 2012).Berdasarkan data kasus jumlah kematian neonatal pada tahun 2014 berjumlah 257 kasus dengan BBLR 40,07 % kasus, asfiksia 23,73 % kasus, tetanus 0,77 % kasus, sepsis 5,83 % kasus, kelainan kongenital 11,67 % kasus, ikterus 1,55 % kasus dan lain-lain 16,34 kasus. Dan pada tahun 2015 dari bulan januari- Agustus 2015 jumlah kematian neonatal berjumlah 160 kasus dengan BBLR 42,5 % kasus, asfiksia 26,87 % kasus, sepsis 2,5 % kasus, kelainan kongenital 6,8 % kasus, ikterus 1,25% kasus, dan lain-lain 20 % kasus.Desain penelitian case control dengan perbandingan 1 : 2, populasi pada penelitian ini adalah semua ibu yang melahirkan bayi yang melahirkan di RSUD Indramayu. sampel penelitian adalah sebagian ibu yang melahirkan bayi berat lahir rendah periode Januari – Maret 2016 sebanyak 58 kasus dan kontrol 116. Pengolahan data menggunakan analisis univariat, uji chi-square dan multivariat (regresi logistik sederhana).Hasil penelitian yang dilakukan dengan melihat data rekam medic (data sekunder) pada 58 kasusdan 116 kontrol dengan metode acak sederhana, ditemukan bahwa factor dominan yang mempengaruhi kejadian BBLR di RSUD Indramayu adalah usia kehamilan dengan p value 0,000 dengan nilai OR 348,327 yang berarti bahawa usia kehamilan mempengaruhi kejadian BBLR sebanyak 348,3327 kali lebih beresiko setelah di control dengan variable lain.
9
Van der Heijde, D., L. S. Gensler, A. Deodhar, X. Baraliakos, D. Poddubnyy, A. Kivitz, M. K. Farmer, et al. "OP0105 EFFICACY AND SAFETY OF BIMEKIZUMAB IN ANKYLOSING SPONDYLITIS: 48-WEEK PATIENT-REPORTED OUTCOMES FROM A PHASE 2B, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 68–69. http://dx.doi.org/10.1136/annrheumdis-2020-eular.323.
Повний текст джерелаАнотація:
Background:Bimekizumab (BKZ), a monoclonal antibody that selectively neutralises interleukin (IL)-17A and IL-17F, is a potential therapeutic option in ankylosing spondylitis (AS).Objectives:To report 48-week (wk) patient-reported outcomes (PROs) in patients (pts) with AS treated with BKZ in a phase 2b dose-ranging study (BE-AGILE;NCT02963506).Methods:Pts with active AS (Bath AS Disease Activity Index [BASDAI] ≥4; spinal pain ≥4 [0–10]), fulfilling modified New York criteria (central reading), and inadequate response/intolerance to NSAIDs were randomised according to the study design (Figure 1). PROs included spinal pain, fatigue (BASDAI Q1), morning stiffness (mean of BASDAI Q5 + 6), Bath AS Functional Index (BASFI), Medical Outcomes Study (MOS) Sleep Problems Index II and AS Quality of Life questionnaire (ASQoL). Efficacy is reported for pts initially randomised to placebo (PBO) or BKZ 160/320 mg every 4 weeks (Q4W); treatment-emergent adverse events (TEAEs) are reported for pts who received ≥1 dose of study drug (Safety Set).Results:Of 303 pts, 181 were randomised to PBO or BKZ 160/320 Q4W mg at Wk 0; 179/181 completed Wk 12 and 161/181 completed Wk 48. At Wk 12, improvements in pain, fatigue, morning stiffness, BASFI, sleep and ASQoL were greater in BKZ pts vs PBO pts. Responses were further improved or maintained to Wk 48, with no meaningful differences between BKZ 160 mg and 320 mg (Table 1). Serious TEAEs occurred in 13/303 (4.3%) pts (Table 2), which included 2 major adverse cardiac events considered not related to study drug. Oral candidiasis occurred in 16 (5.3%) pts.Table 1.PRO efficacy endpoints to Week 48 (multiple imputation)Mean (SD)WkPBO – BKZ 160 mg(n=24)PBO – BKZ 320 mg(n=36)BKZ 160 mg(n=58)BKZ 320 mg(n=61)Spinal pain06.9 (1.4)7.0 (1.9)6.6 (2.0)7.3 (1.5)CfB12-1.5 (1.6)-0.7 (1.7)-2.6 (2.2)-3.6 (2.4)48-3.7 (2.0)-3.7 (2.6)-3.8 (2.4)-4.7 (2.1)Fatigue06.4 (1.7)6.8 (1.6)6.4 (1.7)6.4 (1.9)CfB12-0.7 (2.5)-1.0 (1.7)-2.1 (2.2)-2.1 (2.5)48-2.7 (2.2)-2.8 (2.4)-3.1 (2.1)-3.3 (2.4)Morning stiffness06.9 (1.7)6.7 (2.0)6.5 (1.8)6.6 (2.1)CfB12-1.5 (1.7)-1.1 (1.5)-2.8 (2.0)-3.4 (2.7)48-3.9 (2.2)-3.6 (2.4)-3.9 (2.2)-4.4 (2.4)BASFI05.8 (1.8)5.5 (2.2)5.5 (2.2)5.9 (2.0)CfB12-1.0 (2.1)-0.3 (1.7)-1.7 (1.8)-2.2 (2.0)48-2.9 (2.2)-2.4 (2.2)-2.5 (2.0)-2.9 (2.2)MOS Sleep Problems Index II045.5 (8.1)45.3 (7.9)46.9 (7.5)47.2 (9.4)CfB122.1 (8.3)1.8 (6.8)5.6 (6.7)6.8 (7.5)487.6 (8.7)8.0 (9.1)6.5 (6.1)8.0 (7.9)ASQoL08.4 (4.7)9.2 (4.7)8.4 (4.3)8.7 (4.3)CfB12-1.3 (5.5)-1.3 (3.7)-3.5 (4.3)-4.6 (4.8)48-4.2 (5.6)-5.3 (5.6)-4.9 (4.1)-5.4 (4.8)CfB: change from baselineTable 2.Overview of TEAEs to Week 48 (Safety Set; N=303)n (%)BKZ 160 mg(n=149)BKZ 320 mg(n=150)All BKZ [a](N=303)Any TEAE103 (69.1)122 (81.3)235 (77.6)Drug-related TEAEs48 (32.2)54 (36.0)110 (36.3)Serious TEAEs5 (3.4)6 (4.0)13 (4.3)Discontinuations due to TEAEs7 (4.7)10 (6.7)20 (6.6)[a] Includes TEAEs for 16 and 64 mg BKZConclusion:Pts with active AS demonstrated rapid and sustained improvements in PROs, sleep and quality of life over 48 wks of BKZ treatment. BKZ was generally well tolerated with no unexpected safety findings versus previous studies.Acknowledgments:This study was funded by UCB Pharma. Editorial services were provided by Costello Medical.Disclosure of Interests:Désirée van der Heijde Consultant of: AbbVie, Amgen, Astellas, AstraZeneca, BMS, Boehringer Ingelheim, Celgene, Cyxone, Daiichi, Eisai, Eli-Lilly, Galapagos, Gilead Sciences, Inc., Glaxo-Smith-Kline, Janssen, Merck, Novartis, Pfizer, Regeneron, Roche, Sanofi, Takeda, UCB Pharma; Director of Imaging Rheumatology BV, Lianne S. Gensler Grant/research support from: Pfizer, Novartis, UCB, Consultant of: AbbVie, Eli Lilly, GSK, Novartis, UCB, Atul Deodhar Grant/research support from: AbbVie, Eli Lilly, GSK, Novartis, Pfizer, UCB, Consultant of: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myer Squibb (BMS), Eli Lilly, GSK, Janssen, Novartis, Pfizer, UCB, Speakers bureau: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myer Squibb (BMS), Eli Lilly, GSK, Janssen, Novartis, Pfizer, UCB, Xenofon Baraliakos Grant/research support from: Grant/research support from: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Consultant of: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Speakers bureau: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Denis Poddubnyy Grant/research support from: AbbVie, MSD, Novartis, and Pfizer, Consultant of: AbbVie, Bristol-Myers Squibb, Eli Lilly, MSD, Novartis, Pfizer, Roche, UCB, Speakers bureau: AbbVie, Bristol-Myers Squibb, Eli Lilly, MSD, Novartis, Pfizer, Roche, UCB, Alan Kivitz Shareholder of: AbbVie, Amgen, Gilead, GSK, Pfizer Inc, Sanofi, Consultant of: AbbVie, Boehringer Ingelheim, Flexion, Genzyme, Gilead, Janssen, Novartis, Pfizer Inc, Regeneron, Sanofi, SUN Pharma Advanced Research, UCB, Paid instructor for: Celgene, Genzyme, Horizon, Merck, Novartis, Pfizer, Regeneron, Sanofi, Speakers bureau: AbbVie, Celgene, Flexion, Genzyme, Horizon, Merck, Novartis, Pfizer Inc, Regeneron, Sanofi, Mary Katherine Farmer Employee of: UCB Pharma, Dominique Baeten Employee of: UCB Pharma, Nadine Goldammer Employee of: UCB Pharma, Jason Coarse Employee of: UCB Pharma, Marga Oortgiesen Employee of: UCB Pharma, Maxime Dougados Grant/research support from: AbbVie, Eli Lilly, Merck, Novartis, Pfizer and UCB Pharma, Consultant of: AbbVie, Eli Lilly, Merck, Novartis, Pfizer and UCB Pharma, Speakers bureau: AbbVie, Eli Lilly, Merck, Novartis, Pfizer and UCB Pharma
10
Barbosa, Patricia R., Sally P. Stabler, Mario H. Hirata, Rosario D. C. Hirata, Robert H. Allen, Luiz F. Sampaio-Neto, and Elvira M. Guerra-Shinohara. "Effects of Methionine Synthase (MS) A2756G and Methionine Synthase Reductase (MSR) A66G Polymorphisms on Methionine Metabolism in Brazilian Pregnant Women and Their Neonates." Blood 104, no. 11 (November 16, 2004): 3686. http://dx.doi.org/10.1182/blood.v104.11.3686.3686.
Повний текст джерелаАнотація:
Abstract Methionine synthase (MS) is a cobalamin dependent enzyme that catalyses the remethylation of homocysteine to methionine. The methionine synthase reductase (MSR) maintains adequate levels of methylcob(III)alamin, the activated cofactor for MS. The aim of this study was to investigate the effect of MS A2756G and MSR A66G polymorphisms on total homocysteine (tHcy), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) levels in 390 pregnant women and their 292 newborns, from Sorocaba city, Brazil. Genotypes of two polymorphisms were determined by PCR-RFLP. Pregnant women with MS 2756AA genotype have higher tHcy and lower Cbl levels than those with 2756G alleles. The MMA values were increased in neonates with MS 2756AA genotypes (Table 1). There are no difference between the maternal values of Cbl, serum folate, tHcy, MMA and SAM according to MSR A66G genotypes.The values of SAM were lower in neonates with MSR 66G alleles than those with AA genotypes (Table 2). We conclude that MS 2756AA genotypes are associated with higher tHcy levels in pregnant women and higher MMA levels in neonates. The MSR 66GG genotypes is associated with lower SAM levels in neonates. Table 1- Distribution of geometric means and confidence intervals 95% (CI 95%) and numbers of subjects for maternal and neonatal values of cobalamin (Cbl), serum folate, total homocysteine (tHcy), methymalonic acid (MMA) and S- adenosylmethionine (SAM) according to genotypes for the polymorphism MS A2756G. Variables Genotypes for MS A2756G Student t Test AA AG + GG Pregnant Women Cbl (pmol/L) 139 (133 – 144) 235 156 (146 – 166) 129 P= 0.001 SF (nmol/L) 14.3 (13.6 – 15.0) 234 14.5 (13.6 – 15.5) 129 P= 0.667 tHcy( μmol/L) 6.8 (6.5 – 7.1) 235 6.2 (5.9 – 6.6) 128 P= 0.036 MMA(nmol/L) 234 (219 – 245) 194 241 (219 – 265) 106 P= 0.610 SAM(nmol/L) 81.8 (77.9 – 86,0) 229 83.1 (79.1 – 87.4) 124 P= 0.663 Neonates Cbl (pmol/L) 227 (212 – 244) 188 234 (213 – 257) 101 P= 0.646 SF (nmol/L) 32.0 (31.0 – 33.0) 186 32.0 (30.8 – 33.2) 99 P= 0.967 tHcy μmol/L) 5.8 (5.5 – 6.1) 185 5.5 (5.1 – 5.9) 100 P= 0.229 MMA(nmol/L) 383 (364 – 402) 183 342 (317 – 369) 100 P= 0.011 SAM(nmol/L) 188 (181 – 196) 178 182 (168 – 197) 98 P= 0.491 Table 2 - Distribution of geometric means and confidence intervals 95% (CI (%%) and number of subjects for neonatal values of cobalamin (Cbl), serum folate, total homocysteine (tHcy), methylmalonic acid (MMA) and S- adenosylmethionine (SAM) according to genotypes for the polymorphism MSR A66G. Variables Genotypes MSR A66G Student t Test AA AG GG Groups not sharing a common superscript letter are significantly different at P<0.05 based on Tukey’s test Neonates Cbl (pmol/L) 225 (202 – 249) 86 229 (214 – 246) 166 247 (205 – 298) 35 P= 0.602 SF (nmol/L) 33.0 (31.6 – 34.4) 84 31.7 (30.7 – 32.7) 166 31.8 (29.7 – 34.2) 33 P= 0.352 tHcy μmol/L) ( 5.7 (5.3 – 6.2) 84 5.6 (5.3 – 5.9) 165 5.9 (5.3 – 6.6) 34 P= 0.618 MMA (nmol/L) 360 (334 – 389) 84 378 (357 – 400) 163 339 (299 – 384) 34 P= 0.230 SAM (nmol/L) 200 (186 – 215)a 82 184 (176 – 192)a 159 170 (149 – 195)b 33 P= 0.032
Книги з теми "628.166 : 628.161.2"
1
Головатий, М. Ф. Мистецтво політичної діяльності. Київ: МАУП, 2002.
Знайти повний текст джерела
2
Бондаренко, А. Ф. Основы психологии. Киев: КНЛУ, 2005.
Знайти повний текст джерелаЧастини книг з теми "628.166 : 628.161.2"
1
Eliava, Shalva, Vadim Gorozhanin, Oleg Shekhtman, Yuri Pilipenko, and Olga Kuchina. "Surgical Treatment of Unruptured Brain AVMs: Short- and Long-Term Results." In Acta Neurochirurgica Supplement, 87–90. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63453-7_13.
Повний текст джерелаАнотація:
AbstractUnruptured brain AVMs (bAVMs) remain a controversial subject for practicing neurosurgeons, especially in the light of ARUBA and other observational studies. This retrospective study aims to analyze our experience with unruptured bAVMs to see whether it is beneficial in the long-term and how it corresponds to large literature trials. The study comprised 160 adult patients with unruptured bAVMs surgically treated in Burdenko NMC (Moscow) in 2009–2017. Mean age: 33.4 ± 10лет. Clinical presentations were: seizures in 99 (61.9%), chronical headaches—49 (30.6%), ischemic symptoms—4 (2.5%), asymptomatic in 8 (5%) patients. Spetzler-Martin scale: I—18 pt. (11.3%), II—71 pt. (44.4%), III—60 pt. (37.5%), IV—11 pt. (6.8%). Good outcomes (mRS = 0–2) at discharge were achieved in 149 (93.1%), satisfactory (mRS—3)—9 (5.6%). Follow-up was complete for 97 (60.6%) patients, mean—59.3 (13–108 month). Excellent outcomes (mRS = 0–1) reached in 94.8%. For epilepsy patients, Engel I outcome was found in 50 (84.8%); for chronic headaches, 43 (66.1%) patients reported improvement. Postoperative visual field defects were followed in 22 of 55 (40%), complete recovery was reported in 6 (27%) and partial recovery in 8 (36%) patients. Overall, our results support the conclusion that surgery for low-grade bAVMs (S-M I–II) is a beneficial, low-risk option.
2
Göttler, Dominik. "Überblick über die Voraussetzungen des § 116 S. 1 Nr. 1, S. 2 ZPO." In Die Prozesskostenhilfe für den Insolvenzanfechtungsprozess, 40–70. Wiesbaden: Springer Fachmedien Wiesbaden, 2020. http://dx.doi.org/10.1007/978-3-658-32613-5_3.
Повний текст джерела
3
Georgieva, Ludmila, and Matthias Schmidl. "Article 58 Powers." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0100.
Повний текст джерелаАнотація:
Article 4(21) (Definition of a supervisory authority); Article 36 (Advisory and other powers concerning prior consultation, national legislative measures and mandatory prior consultation or authorisation) (see too recital 94); Article 50 (Supervisory authorities to take steps to provide international mutual assistance in enforcement, including through investigative assistance) (see too recital 116); Article 52 (Exercise of powers with complete independence) (see too recital 117); Article 55 (Competence with regard to the exercise of powers, competence over public bodies) (see too recitals 122, 128 and 131); Article 57 (Tasks of supervisory authorities) (see too recitals 122, 123, 132 and 133); Articles 60(2) and 61 (Mutual assistance) (see too recital 133); Article 62 (Joint operations of supervisory authorities, including joint investigations and conferring of powers) (see too recitals 130 and 134); Article 90 (Possibility for Member States to adopt specific rules to set out supervisory authorities’ powers) (see too recital 164).
4
Blume, Peter. "Article 61 Mutual assistance." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0104.
Повний текст джерелаАнотація:
Article 50 (International cooperation) (see too recital 116); Article 51(2) (Obligation of supervisory authorities to cooperate to ensure consistency) (see too recital 124); Article 56 (Competence of lead supervisory authority) (see too recitals 124–128); Article 57(1)(g) (Tasks of supervisory authorities); Article 60 (Cooperation between lead supervisory authority and supervisory authorities concerned) (see too recitals 130–31); Article 62 (Joint operations of DPAs) (see too recital 134); Article 64(2) (Opinion of the Board in case of non-compliance with Articles 61 or 62) (see too recital 136).
5
Docksey, Christopher. "Article 69 Independence." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0114.
Повний текст джерелаАнотація:
Article 51(1) (Supervisory authority) and Article 52 (Independence of supervisory authorities) (see too recitals 117–118 and 120–121); Article 64(2) (Commission right to request the Board concerning an opinion) (see too recitals 135–136); Article 68(5) (Participation of the Commission in the activities and meetings of the Board).
6
Hijmans, Hielke. "Article 57 Tasks." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0099.
Повний текст джерелаАнотація:
Article 4(21) (Definition of a supervisory authority); Article 28(8) (Adoption of processors’ standard contractual clauses); Article 36(2) (Prior consultation) (see too recitals 84 and 94); Articles 40(1), (5) and 41(3) (Codes of conduct) (see too recital 98); Article 42(1), (5), (7) and 43(1) (Certification) (see too recital 100); Article 46(2)(d), (3) and (4) (Standard data protection clauses for data transfers) (see too recitals 108–109); Article 47 (Approval of binding corporate rules); Article 50 (International cooperation for the protection of personal data) (see too recitals 104 and 116); Article 58 (Powers) (see too recitals 129, 148 and 150); Article 59 (Activity reports); Article 60 (Cooperation between supervisory authorities); Article 61 (Mutual assistance between supervisory authorities); Article 62 (Joint operations of supervisory authorities); Article 70 (Tasks of the Board, including promotion of cooperation between supervisory authorities; contribution to activities of the Board); Article 77 (Complaint handling and investigations) (see too recital 141); Article 83 (Administrative fines) (see too recital 148).
7
Astaíza Aragón, María Claudia, Esteban Ortiz, Gustavo Labrada, and Jhonatan Betancourt Peña. "Factores de riesgo cardiovascular en estudiantes de primer semestre de una universidad de cali." In Región y entorno universitario. Unidos por la promoción de la salud, 103–20. Editorial Universidad Santiago de Cali, 2019. http://dx.doi.org/10.35985/9789585522947.7.
Повний текст джерелаАнотація:
El ingreso a la vida universitaria genera cambios en hábitos de vida que con el tiempo podrían favorecer el desarrollo de enfermedades no trasmisibles (ENT) entre los estudiantes. El objetivo del estudio fue determinar los cambios en comportamientos y en algunas variables antropométricas durante el primer año de estancia universitaria de un grupo de estudiantes en Cali (Colombia). Se recolectaron los datos por medio de un cuestionario y la toma de medidas antropométricas; se realizaron 2 mediciones, la primera con 161 estudiantes y la segunda con 94 estudiantes. El 67% pertenecía al programa de Fisioterapia y el 68% eran mujeres. Se pudo establecer que el sedentarismo pasó de 45.7% a 56.4% y el consumo de bebidas alcohólicas pasó del 6.4% al 25.5%.
8
Taber, Douglass F. "The Hoveyda Synthesis of Disorazole C1." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0102.
Повний текст джерелаАнотація:
Disorazole C1 3, isolated from fermentation of the myxobacterium Sorangium cellulosum, shows antifungal and anticancer activity. Amir H. Hoveyda of Boston College applied (J. Am. Chem. Soc. 2014, 136, 16136) recent advances in alkene metathesis from his group to enable the efficient assembly of 2 and so of 3. The ester 1 was assembled from the alcohol 11 and the acid 18. The preparation of 11 began with the enantioselective addition of 5 to 4 to give 6 and then 7, as described by Kalesse (Angew. Chem. Int. Ed. 2010, 49, 1619). Leighton allylation led to 8, that was then coupled with 9 to give 10 with high Z selectivity. Iodination of 10 followed by deprotection then completed the assembly of 11. The starting material for the acid 18 was the allylic alcohol 13. As reported by Cramer (Angew. Chem. Int. Ed. 2008, 47, 6483), exposure of the racemic alcohol 12 to vinyl acetate in the presence of Amano lipase PS converted one enantiomer to the acetate, leaving 13. Methylation of the secondary alcohol followed by acid-mediated removal of the t-butyl ester led to the acid 14, that was converted to the corresponding acyl fluoride and coupled with serine Me ester 15 to give 16. After cyclization to the oxazole 17, cross metathesis with five equivalents of 4-bromo-1-butene gave the homoallylic bromide, that was readily eliminated with DBU to give, after saponification, the acid 18. The cross metathesis of the coupled ester 1, a polyene, with 9 proceeded with remarkable selectivity to give 2, again as the Z geometric isomer. On exposure to the Heck catalyst Pd [(o-tolyl)3P]2, 2 dimerized efficiently. The deprotection was not straightforward, but conditions (H2SiF6, CH3OH, 4°C, 72 h) were found that delivered 3 in 68% yield.
9
James, Simon. "The Plateau Zone West of G St." In The Roman Military Base at Dura-Europos, Syria. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198743569.003.0019.
Повний текст джерелаАнотація:
One of the first structures explored at Dura in 1920, this temple (or perhaps better, sanctuary: Buchmann 2016, 116) was subsequently completely excavated but never fully published. Preliminary accounts were written by the excavators (Cumont 1926, 29–41; PR 2, 11–12, 67–9 (Pillet), PR 4, 16–19 (Pillet); Rostovtzeff 1938, 68–75 and pl. VI) and it has been much discussed since (Downey 1988, 105–10 for overview and references; Dirven 1999, 326–49 for the Palmyrene evidence; Leriche et al. 2011, 28). It remained a temple through the Roman period, apparently no part of it other than, presumably, the upper levels of city wall Tower 1 being used for secular military purposes. However, its continued existence in the farthest corner of the military base, and its attested use for worship by the Roman military community, demand discussion here. Indeed one of the very first military discoveries was the Terentius wall painting on the N wall of the temple’s room A, depicting a Roman military sacrifice by cohors XX Palmyrenorum before a triad of its national deities and the Tychai of Dura and Palmyra (Pl. I; Breasted 1922; Cumont 1923; Breasted 1924, 94–101, pl. XXI). Cumont consequently called the sanctuary the ‘Temple of the Palmyrene Gods’ (Cumont 1926, 29). In recent decades it has been more usually known as the ‘Temple of (i.e. Palmyrene) Bêl’, following Rostovtzeff (1938, 51), although in Parthian times it was probably dedicated to Zeus (Welles 1969, 63; Millar 1998, 482; Kaizer 2002, 122). No evidence indicates Palmyrene worship in the Parthian-era temple (Dirven 1999, 327–8). There is no consensus on the name for the sanctuary, so I follow MFSED’s ‘Temple of Bêl’ (Leriche et al. 2011, 28; also now Kaizer 2016b, 37–41). Described as laying in ‘J3/5’ by the Yale expedition, it actually lies N of these blocks in an area MFSED has labelled J9 (Leriche et al. 2011, 28–30). During the third century when the temple lay within the Roman base area, it did become the focus of Palmyrene cults, likely ‘related to Palmyrene soldiers or people associated with them’ (Dirven 1999, 328).
10
Oriakhi, Christopher O. "Stoichiometry." In Chemistry in Quantitative Language. Oxford University Press, 2009. http://dx.doi.org/10.1093/oso/9780195367997.003.0013.
Повний текст джерелаАнотація:
Stoichiometry is the study of the quantities of reactants and products involved in a chemical reaction. In addition to identifying the reactants and products in a chemical reaction, a balanced equation gives useful information that is helpful in calculations. Consider the equation for the reaction between ammonia and oxygen to produce nitrogen (II) oxide: 4 NH3(g)+5 O2(g) −→4 NO (g)+6 H2O (g) The following information can be obtained: 1. Molecules of reactant and products: 4 molecules of NH3 react with 5 molecules of O2 to form 4 molecules of NO and 6 molecules of H2O. 2. Moles of reactants and products: 4 mol of NH3 react with 5 mol of O2 to produce 4 mol of NO and 6 mol of H2O. 3. Mass of reactants and products: 68 g of NH3 (4 mol) react with 160 g of O2 (5 mol) to produce 120 g of NO (4 mol) and 108 g of H2O (6 mol). 4. Volumes of gases: 4 volumes of NH3 react with 5 volumes of O2 to produce 4 volumes of NO and 6 volumes of H2O at the same temperature and pressure (by Avogadro’s law, which will be discussed in detail in section 11.5 of chapter 11). There are several types of stoichiometric problems. The common types include: 1. Mole – Mole 2. Mass – Mass 3. Mass – Mole (or Mole – Mass) 4. Mole – Volume (or Volume to Mole) 5. Mass – Volume (or Volume to Mass) 6. Volume – Volume The following general steps can be used to solve many stoichiometric problems: 1. Write the balanced chemical equation for the reaction. 2. Organize your data; determine which quantities you know and which ones you need to find. 3. Write the mole relationship between the given substance (a reactant or a product) and the required substance (a reactant or a product). 4. Calculate molar masses and convert masses, molecules, or volumes of the known substance to moles. 5. Use stoichiometric coefficients or conversion factors (mole ratios) from the equation to determine the moles of the unknown substance. 6. Convert moles of the unknown substance to the desired mass, molecules, or volume.
Тези доповідей конференцій з теми "628.166 : 628.161.2"
1
Woods, A. I., and M. A. Lazzari. "ASPIRIN FAILURE TO INHIBIT THE RELEASE OF PLASMINOGEN ACTIVATORS-INHIBITORS BY HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643126.
Повний текст джерелаАнотація:
Platelet-PA-Inhibitors can be released by thrombin, Col laaen( Col) and others.If they are physiologically important,inhibition of their release might facilitate thrombolysis.Intrinsic PA were tested in euclobulins (eug)of PPP and PPP+Washed platelets(WP) ,with and without aspirinf ASA) .treated with UK,SK and Col(20 atfd l2uo/ml) Results(mm2)were:euaPPP:232+78;+3×106WP/ul:217+71;+10%7ul:188+/5 +2×106MP/ul: 157+69:With UK:eugPPP:283+76;+3×l0517P/ul :234+69;+106 WP/ul :172+55;+2×l(PWP/ul :154+48; With SK:euoPPP:303+99;+3×l05WP/ul 252+65;+1067P/ul:203+68;+2×106UP/ul: 174+85;Wi th Col (20ug/ml) :eur PPP:234+97;+3×105WP/ul:160+63;+106WP/ul:141+73;+2×l06WP/ul:129+81; +2×106WP/ul+ASA: 105+31;Wi th Col uc/ml) :euaPPP:230+56;+3×l05NP/ul: 160+52;+106WP/ul:139+44;+2×106wp/ul:126+21;+2×106WP/ul+ASA:118+28. EugPPP+l/P showed lower lysis area.Col induced more decrease of lysis area in euc with WP.ASA did not modify this effect.UK and SK produced higher lysis area only in euoPPP.No difference was observed between high and low doses of Col-effect upon WP.Combined treatment of eucPPP+WP+Col, with UK and SK showed:(mm2):UK-treated eugPPP+2×106WP/ul+Col(29ug/ml):134+25;+ASA and Col(20ug/ml):115+65;+Col(2uc/ml):157+50;+ASA and Col(2uo/ml):133+49; SK-treated eupPPP+2×106WP/ul:+Col(20uo/ml):144+49;+ASA and Col(20ug/ml):128+ 60;+Co1(2ug/ml):173+66;+ASA and Col(2ug/ml):142+36.Col (20ug/ml) produced slight lower lysis area of UK and SK-treated eugPPP+WP. (p:ns). ASA did not modify this effect.Col (2uc/ml) did not produce changes in lysis area of UK and SK-treated eupPPP +WP. ASA produced slight lower lysis area(p:ns).Conclusion: high dosis of Col could release anti UK,anti SK and intrinsic PA-inhibitors from platelets;low dosis of Col could only release fntrinsic PA-inhibi tors. It suggests that anti UK and anti SK release might be triggered by stronger stimuli than intrinsic PA inhibitors.ASA could not inhibit any inhibitors release.We must consider that PA-inhibi tors could be released by different metabolic pathways other than cyclooxygenase pathway.
2
Westenhöfer, Joachim, Johanna Buchcik, and Jana Borutta. "Healthy Neighbourhoods: Health Promotion and Prevention in Urban Neighbourhoods." In CARPE Conference 2019: Horizon Europe and beyond. Valencia: Universitat Politècnica València, 2019. http://dx.doi.org/10.4995/carpe2019.2019.10216.
Повний текст джерелаАнотація:
Introduction Maintaining good life quality in urban neighbourhoods is one of the biggest challenges. The project "Healthy Neighbourhoods - Health Promotion and Prevention in Districts" ( 07/201712/2020) aims to describe and improve health and quality of life of citizens living in neighbourhoods with different socioeconomic statuses. Method To examine a possible connection between social and health situation, six districts with "very low", "low", "middle" and "high" social statuses will be compared. An instrument was developed to measure walkability, community sense, nutrition, alcohol and tobacco consumption, resilience, health-related quality of life as well as the socio-economic and the socio-demographic status. Results In April 2019, the team recorded n=621 interviews (n=102 in Lohbrügge, n=116 in Rahlstedt, n=87 in Sasel, n=135 in Stellingen, n=65 Wilhelmsburg and n=116 in Hamm). Men were somewhat overrepresented compared to women (n=268 woman, n=345 men, n=2 diverse, n=8 no indication). Respondents were aged between 18 - 96 (mean = 57.5, SD = 19.6). Discussion The results demonstrate different health situations, resources and challenges regarding the socio-economic status and the district respectively. To ensure a participative approach, the results will be presented to citizens and health experts living in these districts and form the basis to develop health promoting intervention.
3
Kang, Dae-Il, Kil-Yoo Kim, and Jae-Joo Ha. "Importance Analysis of In-Service Testing Components for Ulchin Unit 3." In 10th International Conference on Nuclear Engineering. ASMEDC, 2002. http://dx.doi.org/10.1115/icone10-22180.
Повний текст джерелаАнотація:
We performed an importance analysis of In-Service Testing (IST) components for Ulchin Unit 3 using the integrated evaluation method for categorizing component safety significance developed in this study. The importance analysis using the developed method is initiated by ranking the component importance using quantitative PSA information. The importance analysis of the IST components not modeled in the PSA is performed through the engineering judgment, based on the expertise of PSA, and the quantitative and qualitative information for the IST components. The PSA scope for importance analysis includes not only Level 1 & 2 internal PSA but also Level 1 external and shutdown/low power operation PSA. The importance analysis results of valves show that 167 (26.55%) of the 629 IST valves are HSSCs and 462 (73.45%) are LSSCs. Those of pumps also show that 28 (70%) of the 40 IST pumps are HSSCs and 12 (30%) are LSSCs.
4
Quinnell, Josh A., and Jane H. Davidson. "Buoyancy Driven Mass Transfer in a Liquid Desiccant Storage Tank." In ASME 2012 6th International Conference on Energy Sustainability collocated with the ASME 2012 10th International Conference on Fuel Cell Science, Engineering and Technology. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/es2012-91315.
Повний текст джерелаАнотація:
A new concept for long-term solar storage is based on the absorption properties of aqueous calcium chloride. Water, diluted and concentrated calcium chloride solutions are stored in a single tank. An immersed heat exchanger and stratification manifold are used to preserve long-term sorption storage, and to achieve thermal stratification. The feasibility of the concept is demonstrated via measurements of velocity, CaCl2 mass fraction, and temperature in a 1500 liter prototype tank during sensible charging. Experiments are conducted over a practical range of the relevant dimensionless parameters. For Rayleigh numbers from 3.4 × 108 to 5.6 × 1010 and buoyancy ratios from 0.8 to 46.2, measured Sherwood numbers are 11±2 to 62±9 and the tank is thermally stratified. Convective mixing is inhibited by the presence of a steep density gradient at the interface between regions of differing mass fraction. The predicted storage time scales for the reported Sherwood numbers are 160 to 902 days.
5
Cavanagh, Daniel P., Asena Abay, Jessica M. Brito, Jasmine R. Joyner, Jordyn N. Nally, and Xianren Wu. "A Novel Epidural Catheter Fixation Device." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3490.
Повний текст джерелаАнотація:
Epidurals are a method of long-term pain relief administered by injecting and continuously delivering an anesthetic via catheter in the spine. This method of pain relief is often used for patients in the Obstetrics/Gynecology unit as well as those in pre- and post-operational care. For almost 2 million singleton vaginal deliveries across 27 states in 2008 (representing 65% of all US singleton vaginal births in 2008), 61% of patients received some form of an epidural or spinal injection [1]. Additionally, this number has been increasing. For the 18 states for which 2006 and 2008 data are available, the average of the state-level increases in epidural/spinal injections is approximately 4.2% revealing an overall increase in these injections. Just between 2000 and 2010, the use of epidural injections increased by 160% [2]. Commonly, epidural catheters are inserted into the patient’s back in the appropriate location and then secured to the body with an adhesive medical dressing. Movement and subsequent dislocation of the catheter beneath the adhesive medical dressing can result in inefficient anesthetic delivery, increased patient discomfort, and repeated administration of the epidural. Secondary migration of epidural catheters is a problem responsible for failure in approximately 6.8% of epidurals administered [3]. Requiring an anesthesiologist to repeat the procedure is also an increased cost. A solution to secondary migration of epidural catheters would ensure effective delivery of the anesthetic to the patient, reduce the need for a repeated procedure, and prevent unwanted additional healthcare expenses.
6
Wickham, N. W. R., G. M. Vercellotti, H. Q. Yin, H. S. Jacob, and C. F. Moldow. "ENDOTHELIAL CELLS PRODUCE PLATELET ACTIVATING FACTOR WHICH PRIMES NEUTROPHILS TO RELEASE OXIDANT PRODUCTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642861.
Повний текст джерелаАнотація:
Thrombin (THR) is generated during ARDS, sepsis and DIC. We wondered whether it might augment PMN/endothelial cell (EC) interaction and hence amplify EC damage by inducing platelet activating factor (PAF) (JCI 76:2235-2246;1985). To examine further this premise and the mechanisms involved, we measured intracel1ular calcium (Ca1) in human EC (grown on glass cover slips), in a scanning spectrof1uorometer at 37°C after loading with FURA 2 (4μM). Resting Ca1 was 148±22 nM (Mean±SEM) which increased following THR 0.5u/ml to 458±160 nM at 30s, peaking after 1 min at 559±176 nM, and returning to 273±42 nM by 5 min. Phosphatidyl inositol (PI) turnover was assessed in 3H-myoinositol-loaded EC using water-soluble extracts separated by Dowex anion exchange chromatography. Within 30s of THR (lu/ml) stimulation, PI turnover markedly increased, with production of inositol bi- and tri-phosphates showing a >5 fold rise. Associated with these perturbations, THR-treated EC monolayers enhanced O2- generation by FMLP(10™7)-stimulated PMNs (basal levels of 5.73±0.68 O2-/15 min/106 PMN rising to 8.01±0.85 nM (p<0.05)); moreover this enhancement could be completely inhibited with a newly described PAF antagonist BN 52021. PAF production is dependent upon phosphorylation of an acetyl transferase, and Ca1 flux and PI hydrolysis are events known to be associated with protein kinase activation. THR-EC stimulation would seem, therefore, to initiate a sequence of events involving PMN/EC 'cross-talk' leading to contact activation of marginated PMNs by EC-derived PAF. This is an example of a novel paracrine response, and is consistent with our data showing the potent priming effect of PAF on PMN oxidant responses (Blood 68:88A; 1986) and provides evidence for a previously unsuspected pathway that promotes PMN oxidant-mediated EC injury during sepsis or other THR-generating disorders.
7
Wagner, Patrick H., Jan Van herle, Lili Gu, and Jürg Schiffmann. "Influence of Large Relative Tip Clearances for a Micro Radial Fan and Design Guidelines for Increased Efficiency." In ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-15994.
Повний текст джерелаАнотація:
Abstract The blade tip clearance loss was studied experimentally and numerically for a micro radial fan with a tip diameter of 19.2mm. Its relative blade tip clearance, i.e., the clearance divided by the blade height of 1.82 mm, was adjusted with different shims. The fan characteristics were experimentally determined for an operation at the nominal rotational speed of 168 krpm with hot air (200 °C). The total-to-total pressure rise and efficiency increased from 49 mbar to 68 mbar and from 53% to 64%, respectively, by reducing the relative tip clearance from 7.7% to the design value of 2.2%. Single and full passage computational fluid dynamics simulations correlate well with these experimental findings. The widely-used Pfleiderer loss correlation with an empirical coefficient of 2.8 fits the numerical simulation and the experiments within +2 efficiency points. The high sensitivity to the tip clearance loss is a result of the design specific speed of 0.80, the highly-backward curved blades (17°), and possibly the low Reynolds number (1 × 105). The authors suggest three main measures to mitigate the blade tip clearance losses for small-scale fans: (1) utilization of high-precision surfaced-grooved gas-bearings to lower the blade tip clearance, (2) a mid-loaded blade design, and (3) an unloaded fan leading edge to reduce the blade tip clearance vortex in the fan passage.
8
Lottenberg, R., and J. A. Hall. "EVALUATION OF PLASMINOGEN IN HYPERCOAGULABLE PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644837.
Повний текст джерелаАнотація:
Sixty seven patients with spontaneous or recurrent thrombosis without obvious underlying disorders were evaluated for plasminogen abnormalities. The mean age was 33.5 years. Fifty seven had venous thrombosis, five had arterial thrombosis and five had both venous and arterial events. Seventeen patients had family members with a history of similar thrombotic events. The plasminogen antigen concentration, by Laurell immunoelectrophoresis, for the patient group was 104± 19% (62-156) compared to 102±11% (83-122) for normal controls (n=24). By amidolytic assay of plasminogen-streptokinase complexes, the activity was proportionate to the antigenic concentration for each individual. Two patients had plasminogen levels (62%, 67%) lower than 2 standard deviations of the mean. Functional alpha2-antiplasmin levels were the same for the patients (102±11%) and the controls (101±16%). Plasminogen activation in undiluted plasma was assessed by a coupled amidolytic assay using urokinase (60 IU/ml) and H-D-val-leu-lys-pNA. The mean substrate hydrolysis rate for the patient group was 1.35±0.52 10−3 absorbance units/min/min (0.56−2.75) compared to 1.32±0.27 10−3 absorbance units/min/min (0.84-−1.99) for the controls (n=34). Three patients with normal plasminogen levels had consistently low activation rates (0.56, 0.57, 0.65). Inhibition of urokinase and plasmin activity was not increased. Histidine-rich glycoprotein levels were not elevated. Electrophoretic, chromatographic and kinetic analysis of the isolated plasminogens revealed no abnormalities. To assess the high affinity lysine binding site, 40 uM epsilon aminocaproic acid was added to plasma while the change in the plasminogen activation rate relative to baseline was observed; no abnormalities were disclosed in either the patient or control populations.In summary, two patients had significantly reduced levels of normally functioning plasminogen. Dysfunctional plasminogen was not identified in this population. We conclude that plasminogen abnormalities infrequently explain hypercoagulability. These studies also suggest that plasminogen status can be adequately evaluated by determining the antigenic concentration and functional activity of plasminogen-streptokinase complexes.
9
Diez, F. J., L. P. Bernal, and G. M. Faeth. "Self-Preserving Mixing Properties of Steady Round Buoyant Turbulent Plumes in Uniform Crossflows." In ASME 2005 Fluids Engineering Division Summer Meeting. ASMEDC, 2005. http://dx.doi.org/10.1115/fedsm2005-77054.
Повний текст джерелаАнотація:
The self-preserving mixing properties of steady round buoyant turbulent plumes in uniform crossflows were investigated experimentally. The experiments involved salt water sources injected into fresh water crossflows within the windowed test section of a water channel. Mean and fluctuating concentrations of source fluid were measured over cross sections of the flow using Planar-Laser-Induced-Fluorescence (PLIF) which involved seeding the source fluid with Rhodamine 6G dye and adding small concentrations of ethanol to the crossflowing fluid in order to match the refractive indices of the source flow and the crossflow. The self-preserving penetration properties of the flow were correlated successfully based on the scaling analysis of Diez et al. (2003) whereas the self-preserving structure properties of the flow were correlated successfully based on the scaling analysis of Fischer et al. (1979); both approaches involved assumptions of no-slip convection in the cross stream (horizontal) direction (parallel to the crossflow) and a self-preserving line thermal having a conserved source specific buoyancy flux per unit length that moves in the streamwise (vertical) direction (parallel to the direction of both the initial source flow and the gravity vector). The resulting self-preserving structure consisted of two counter-rotating vortices having their axes nearly aligned with the crossflow direction that move away from the source in the streamwise (vertical) direction due to the action of buoyancy. Present measurements extended up to 202 and 620 source diameters from the source in the streamwise and cross stream directions, respectively. The onset of self-preserving behavior required that the axes of the counter-rotating vortex system be nearly aligned with the crossflow direction. This alignment, in turn, was a strong function of the source/crossflow velocity ratio, uo/v∞. The net result was that the onset of self-preserving behavior was observed at streamwise distances of 10–20 source diameters from the source for uo/v∞ = 4 (the smallest value of uo/v∞ considered), increasing to streamwise distances of 160–170 source diameters from the source for uo/v∞ = 100 (the largest value of uo/v∞ considered). Finally, the counter-rotating vortex system was responsible for substantial increases in the rate of mixing of the source fluid with the ambient fluid compared to axisymmetric round buoyant turbulent plumes in still environments, e.g., transverse dimensions in the presence of the self-preserving counter-rotating vortex system were 2–3 times larger than the transverse dimensions of self-preserving axisymmetric plumes at similar streamwise distances from the source.
10
Duva, B. C., L. E. Chance, and E. Toulson. "Effect of CO2 Dilution on the Laminar Burning Velocities of Premixed Methane/Air Flames at Elevated Temperature." In ASME Turbo Expo 2019: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/gt2019-90918.
Повний текст джерелаАнотація:
Abstract With increased interest in reducing emissions, the staged combustion concept for gas turbine combustors is gaining in popularity. For this work, the effect of CO2 dilution on laminar burning velocities of premixed methane/air flames was investigated at elevated temperature through both experiments and numerical simulations. Validation of the experimental setup and methodology was completed through experimental testing of methane/air mixtures at 1 bar and 298 K. Following validation, high temperature experiments were conducted in an optically accessible constant volume combustion chamber at 1 bar and 473 K. Laminar burning velocities of premixed methane/air flames with 0%, 5%, 10% and 15% CO2 dilution were determined using the constant pressure method enabled via schlieren visualization of the spherically propagating flame front. Results show that laminar burning velocities of methane/air mixtures at 1 bar increase by 106–145% with initial temperature increases from 298 K to 473 K. Additions of 5%, 10% and 15% CO2 dilution at 1 bar and 473 K cause a 30–35%, 51–54% and 66–68% decrease in the laminar burning velocity, respectively. Numerical results were obtained with CHEMKIN [1] using the GRI-Mech 3.0 [2] and the San Diego [3] mechanisms. Excellent agreement was observed between the GRI-Mech 3.0 [2] and experimental data at ϕ ≤ 1.2 for methane/air mixtures at 1 bar and 298 K. However, for mixtures at ϕ < 1.3, 1 bar and 473 K, mixtures at ϕ < 1.2 for 5% and 10% dilutions, and for mixtures at ϕ < 0.9 for 15% dilution, laminar burning velocities predicted by the GRI-Mech 3.0 mechanism [2] were slightly higher than experimental results. The San Diego mechanism [3] showed good agreement with experimental data at ϕ ≤ 0.9 for methane/air mixtures at 1 bar and 298 K. However, for mixtures at ϕ > 0.9, 1 bar and 298 K, mixtures at ϕ > 1.2, 1 bar and 473 K, and mixtures at ϕ > 1.1 with 5%, 10% and 15% dilution, the San Diego mechanism [3] predicted slower laminar flame speeds than the experimental results. On the other hand, the laminar burning velocities predicted by the San Diego mechanism [3] were slightly faster than the experimental results for leaner mixtures. Additionally, the dilution, thermal-diffusion, and chemical effects of CO2 on the laminar burning velocities of methane/air mixtures were investigated numerically by diluting the mixtures with both chemically active and inactive CO2 following the determination of the most important elementary reactions on the burning rate through sensitivity analysis. Lastly, it was shown that CO2 dilution suppresses the flame instabilities during combustion, which is attributable to the increase in the burned gas Markstein length (Lb) with the addition of diluent.
Звіти організацій з теми "628.166 : 628.161.2"
1
Weinschenk, Craig, Daniel Madrzykowski, and Paul Courtney. Impact of Flashover Fire Conditions on Exposed Energized Electrical Cords and Cables. UL Firefighter Safety Research Institute, October 2019. http://dx.doi.org/10.54206/102376/hdmn5904.
Повний текст джерелаАнотація:
A set of experiments was conducted to expose different types of energized electrical cords for lamps, office equipment, and appliances to a developing room fire exposure. All of the cords were positioned on the floor and arranged in a manner to receive a similar thermal exposure. Six types of cords commonly used as power supply cords, extension cords, and as part of residential electrical wiring systems were chosen for the experiments. The non-metallic sheathed cables (NMB) typically found in residential electrical branch wiring were included to provide a link to previous research. The basic test design was to expose the six different types of cords, on the floor of a compartment to a growing fire to determine the conditions under which the cord would trip the circuit breaker and/or undergo an arc fault. All of the cords would be energized and installed on a non-combustible surface. Six cord types (18-2 SPT1, 16-3 SJTW, 12-2 NM-B, 12-3 NM-B, 18-3 SVT, 18-2 NISPT-2) and three types of circuit protection (Molded case circuit breaker (MCCB), combination Arc-fault circuit interrupter (AFCI), Ground-fault circuit interrupter (GFCI)) were exposed to six room-scale fires. The circuit protection was remote from the thermal exposure. The six room fires consisted of three replicate fires with two sofas as the main fuel source, two replicate fires with one sofa as the main fuel source and one fire with two sofas and MDF paneling on three walls in the room. Each fuel package was sufficient to support flashover conditions in the room and as a result, the impact on the cords and circuit protection was not significantly different. The average peak heat release rate of the sofa fueled compartment fires with gypsum board ceiling and walls was 6.8 MW. The addition of vinyl covered MDF wall paneling on three of the compartment walls increased the peak heat release rate to 12 MW, although most of the increased energy release occurred outside of the compartment opening. In each experiment during post flashover exposure, the insulation on the cords ignited and burned through, exposing bare conductor. During this period the circuits faulted. The circuit protection devices are not designed to provide thermal protection, and, thus, were installed remote from the fire. The devices operated as designed in all experiments. All of the circuit faults resulted in either a magnetic trip of the conventional circuit breaker or a ground-fault trip in the GFCI or AFCI capable circuit protection devices. Though not required by UL 1699, Standard for Safety for Arc-Fault Circuit-Interrupters as the solution for detection methodology, the AFCIs used had differential current detection. Examination of signal data showed that the only cord types that tripped with a fault to ground were the insulated conductors in non-metallic sheathed cables (12-2 NM-B and 12-3 NM-B). This was expected due to the bare grounding conductor present. Assessments of both the thermal exposure and physical damage to the cords did not reveal any correlation between the thermal exposure, cord damage, and trip type.
2
Stall, Nathan M., Kevin A. Brown, Antonina Maltsev, Aaron Jones, Andrew P. Costa, Vanessa Allen, Adalsteinn D. Brown, et al. COVID-19 and Ontario’s Long-Term Care Homes. Ontario COVID-19 Science Advisory Table, January 2021. http://dx.doi.org/10.47326/ocsat.2021.02.07.1.0.
Повний текст джерелаАнотація:
Key Message Ontario long-term care (LTC) home residents have experienced disproportionately high morbidity and mortality, both from COVID-19 and from the conditions associated with the COVID-19 pandemic. There are several measures that could be effective in preventing COVID-19 outbreaks, hospitalizations, and deaths in Ontario’s LTC homes, if implemented. First, temporary staffing could be minimized by improving staff working conditions. Second, homes could be further decrowded by a continued disallowance of three- and four-resident rooms and additional temporary housing for the most crowded homes. Third, the risk of SARS-CoV-2 infection in staff could be minimized by approaches that reduce the risk of transmission in communities with a high burden of COVID-19. Summary Background The Province of Ontario has 626 licensed LTC homes and 77,257 long-stay beds; 58% of homes are privately owned, 24% are non-profit/charitable, 16% are municipal. LTC homes were strongly affected during Ontario’s first and second waves of the COVID-19 pandemic. Questions What do we know about the first and second waves of COVID-19 in Ontario LTC homes? Which risk factors are associated with COVID-19 outbreaks in Ontario LTC homes and the extent and death rates associated with outbreaks? What has been the impact of the COVID-19 pandemic on the general health and wellbeing of LTC residents? How has the existing Ontario evidence on COVID-19 in LTC settings been used to support public health interventions and policy changes in these settings? What are the further measures that could be effective in preventing COVID-19 outbreaks, hospitalizations, and deaths in Ontario’s LTC homes? Findings As of January 14, 2021, a total of 3,211 Ontario LTC home residents have died of COVID-19, totaling 60.7% of all 5,289 COVID-19 deaths in Ontario to date. There have now been more cumulative LTC home outbreaks during the second wave as compared with the first wave. The infection and death rates among LTC residents have been lower during the second wave, as compared with the first wave, and a greater number of LTC outbreaks have involved only staff infections. The growth rate of SARS-CoV-2 infections among LTC residents was slower during the first two months of the second wave in September and October 2020, as compared with the first wave. However, the growth rate after the two-month mark is comparatively faster during the second wave. The majority of second wave infections and deaths in LTC homes have occurred between December 1, 2020, and January 14, 2021 (most recent date of data extraction prior to publication). This highlights the recent intensification of the COVID-19 pandemic in LTC homes that has mirrored the recent increase in community transmission of SARS-CoV-2 across Ontario. Evidence from Ontario demonstrates that the risk factors for SARS-CoV-2 outbreaks and subsequent deaths in LTC are distinct from the risk factors for outbreaks and deaths in the community (Figure 1). The most important risk factors for whether a LTC home will experience an outbreak is the daily incidence of SARS-CoV-2 infections in the communities surrounding the home and the occurrence of staff infections. The most important risk factors for the magnitude of an outbreak and the number of resulting resident deaths are older design, chain ownership, and crowding. Figure 1. Anatomy of Outbreaks and Spread of COVID-19 in LTC Homes and Among Residents Figure from Peter Hamilton, personal communication. Many Ontario LTC home residents have experienced severe and potentially irreversible physical, cognitive, psychological, and functional declines as a result of precautionary public health interventions imposed on homes, such as limiting access to general visitors and essential caregivers, resident absences, and group activities. There has also been an increase in the prescribing of psychoactive drugs to Ontario LTC residents. The accumulating evidence on COVID-19 in Ontario’s LTC homes has been leveraged in several ways to support public health interventions and policy during the pandemic. Ontario evidence showed that SARS-CoV-2 infections among LTC staff was associated with subsequent COVID-19 deaths among LTC residents, which motivated a public order to restrict LTC staff from working in more than one LTC home in the first wave. Emerging Ontario evidence on risk factors for LTC home outbreaks and deaths has been incorporated into provincial pandemic surveillance tools. Public health directives now attempt to limit crowding in LTC homes by restricting occupancy to two residents per room. The LTC visitor policy was also revised to designate a maximum of two essential caregivers who can visit residents without time limits, including when a home is experiencing an outbreak. Several further measures could be effective in preventing COVID-19 outbreaks, hospitalizations, and deaths in Ontario’s LTC homes. First, temporary staffing could be minimized by improving staff working conditions. Second, the risk of SARS-CoV-2 infection in staff could be minimized by measures that reduce the risk of transmission in communities with a high burden of COVID-19. Third, LTC homes could be further decrowded by a continued disallowance of three- and four-resident rooms and additional temporary housing for the most crowded homes. Other important issues include improved prevention and detection of SARS-CoV-2 infection in LTC staff, enhanced infection prevention and control (IPAC) capacity within the LTC homes, a more balanced and nuanced approach to public health measures and IPAC strategies in LTC homes, strategies to promote vaccine acceptance amongst residents and staff, and further improving data collection on LTC homes, residents, staff, visitors and essential caregivers for the duration of the COVID-19 pandemic. Interpretation Comparisons of the first and second waves of the COVID-19 pandemic in the LTC setting reveal improvement in some but not all epidemiological indicators. Despite this, the second wave is now intensifying within LTC homes and without action we will likely experience a substantial additional loss of life before the widespread administration and time-dependent maximal effectiveness of COVID-19 vaccines. The predictors of outbreaks, the spread of infection, and deaths in Ontario’s LTC homes are well documented and have remained unchanged between the first and the second wave. Some of the evidence on COVID-19 in Ontario’s LTC homes has been effectively leveraged to support public health interventions and policies. Several further measures, if implemented, have the potential to prevent additional LTC home COVID-19 outbreaks and deaths.
3
Goetsch, Arthur L., Yoav Aharoni, Arieh Brosh, Ryszard (Richard) Puchala, Terry A. Gipson, Zalman Henkin, Eugene D. Ungar, and Amit Dolev. Energy Expenditure for Activity in Free Ranging Ruminants: A Nutritional Frontier. United States Department of Agriculture, June 2009. http://dx.doi.org/10.32747/2009.7696529.bard.
Повний текст джерелаАнотація:
Heat production (HP) or energy expenditure for activity (EEa) is of fundamental nutritional importance for livestock because it determines the proportion of ingested nutrients available for productive functions. Previous estimates of EEa are unreliable and vary widely with different indirect methodologies. This leads to erroneous nutritional strategies, especially when intake on pasture does not meet nutritional requirements and supplementation is necessary for acceptable production. Therefore, the objective of this project was to measure EEa in different classes of livestock (beef cattle and goats) over a wide range of ecological and management conditions to develop and evaluate simple means of prediction. In the first study in Israel, small frame (SF) and large frame (LF) cows (268 and 581 kg) were monitored during spring, summer, and autumn. Feed intake by SF cows per unit of metabolic weight was greater (P < 0.001) than that by LF cows in both spring and summer and their apparent selection of higher quality herbage in spring was greater (P < 0.10) than that of LF cows. SF cows grazed more hours per day and walked longer distances than the LF cows during all seasons. The coefficient of specific costs of activities (kJ•kg BW-0.75•d-1) and of locomotion (J•kg BW-0.75•m-1) were smaller for the SF cows. In the second study, cows were monitored in March, May, and September when they grazed relatively large plots, 135 and 78 ha. Energy cost coefficients of standing, grazing, and horizontal locomotion derived were similar to those of the previous study based on data from smaller plots. However, the energy costs of walking idle and of vertical locomotion were greater than those found by Brosh et al. (2006) but similar to those found by Aharoni et al. (2009). In the third study, cows were monitored in February and May in a 78-ha plot with an average slope of 15.5°, whereas average plot slopes of the former studies ranged between 4.3 and 6.9°. Energy cost coefficients of standing, grazing, and walking idle were greater than those calculated in the previous studies. However, the estimated energy costs of locomotion were lower in the steeper plot. A comparison on a similar HP basis, i.e., similar metabolizable energy (ME) intake, shows that the daily energy spent on activities in relation to daily HP increased by 27% as the average plot slope increased from 5.8 and 6.02 to 15.5°. In the fourth study, cows grazing in a woodland habitat were monitored as in previous studies in December, March, and July. Data analysis is in progress. In the first US experiment, Boer and Spanish does with two kids were used in an experiment beginning in late spring at an average of 24 days after kidding. Two does of each breed resided in eight 0.5-ha grass/forb pastures. Periods of 56, 60, 63, 64, and 73 days in length corresponded to mid-lactation, early post-weaning, the late dry period, early gestation, and mid-gestation. EEa expressed as a percentage of the ME requirement for maintenance plus activity in confinement (EEa%) was not influenced by stocking rate, breed, or period, averaging 49%. Behavioral activities (e.g., time spent grazing, walking, and idle, distance traveled) were not highly related to EEa%, although no-intercept regressions against time spent grazing/eating and grazing/eating plus walking indicated an increase in EEa% of 5.8 and 5.1%/h, respectively. In the second study, animal types were yearling Angora doeling goats, yearling Boer wether goats, yearling Spanish wether goats, and Rambouilletwether sheep slightly more than 2 yr of age. Two animals of each type were randomly allocated to one of four pastures 9.3, 12.3, 4.6, and 1.2 ha in area. The experiment was conducted in the summer with three periods, 30, 26, and 26 days in length. EEa% was affected by an interaction between animal type and period (Angora: 16, 17, and 15; Boer: 60, 67, and 34; Spanish: 46, 62, and 42; sheep: 22, 12, and 22% in periods 1, 2, and 3, respectively (SE = 6.1)). EEa% of goats was predicted with moderate accuracy (R2 = 0.40-0.41) and without bias from estimates of 5.8 and 5.1%/h spent grazing/eating and grazing/eating plus walking, respectively, determined in the first experiment; however, these methods were not suitable for sheep. These methods of prediction are simpler and more accurate than currently recommended for goats by the National Research Council.