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Статті в журналах з теми "621.3 (09) (04)"

Автор: Grafiati
Опубліковано: 30 травня 2022
Оновлено: 31 травня 2022

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1

Xi, Jing, Kathleen Harnden, Jingqin Luo, Greg S. Call, Elizabeth Mauer, Karyn Ronski, Cynthia X. Ma, and Neil Vasan. "Abstract P3-09-04: Genomic landscape of HER2-negative advanced or metastatic breast cancer with PIK3CA gain-of-function mutations." Cancer Research 82, no. 4_Supplement (February 15, 2022): P3–09–04—P3–09–04. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-09-04.

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Abstract Background: Alpelisib and fulvestrant are used as a combination treatment option for postmenopausal PIK3CA-mutated, hormone receptor positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced or metastatic breast cancer (a/mBC) patients. However, despite the presence of activating mutations in PIK3CA, the majority of patients do not derive benefit, or ultimately progress while on alpelisib therapy. Here, we investigate the genomic landscape of PIK3CA-mutated, HER2- a/mBC using next-generation sequencing (NGS) to provide insight into possible mechanisms of therapeutic resistance to alpelisib/fulvestrant and to identify potential targetable pathways. Methods: We utilized the Tempus LENS platform to retrospectively analyze de-identified NGS data from 2,918 a/mBC patients with formalin-fixed, paraffin-embedded tumor biopsies sequenced using the Tempus|xT solid tumor assay (DNA-seq of 595-648 genes at 500x coverage; full transcriptome RNA-seq). Mutations identified included germline and/or somatic single nucleotide variants, insertions/deletions and copy number variations (gains defined as ≥8 copies). We used curated clinical data to determine HER2 and hormone receptor (ER/PR) status. Results: Among 2,918 a/mBC patients, we identified somatic mutations in PIK3CA in 782 (26.8%). Within these tumors, 629 (80.4%) had one of the 11 mutations currently included in the alpelisib companion diagnostic, and we focused on this population (here defined as mut-PIK3CA). Of these 629, 546 (86.8%) were HER2-, with 176 (32.3%) and 370 (67.7%) derived from primary and metastatic tumors, respectively. Cases were further classified as HR+ (defined as ER+ or PR+) or triple negative (TNBC). While the majority of mutPIK3CA samples were identified in HR+ disease, 10% of the cases occurred in TNBC. Within the mutPIK3CA cohort, tumor mutational burden high (TMB-H; defined as ≥10 mutations/MB) was detected in 11.5% of samples, while microsatellite instability high (MSI-H) was detected in 0.5%. MSI-H was detected at a higher frequency in TNBC compared to HR+. Overall, the most commonly co-mutated genes among mutPIK3CA, HER2- samples were TP53 (34.6%), CDH1 (21.6%), ESR1 (12.3%), KMT2C (11%), MAP3K1 (9.5%), ARID1A (8.1%), PTEN (6.8%), GATA3 (6.6%), NF1 (5.9%), and TBX3 (5.9%) among others (Table 1); some of these genes have previously been implicated in resistance to endocrine therapy or PI3K inhibitor. In addition, in HR+ disease, metastatic samples had a higher frequency of mutations in genes implicated in endocrine resistance, such as ESR1 (18.7% vs 1.9%), ERBB2 (3.3% vs 2.6%), NF1 (6.8% vs 2.6%), compared to primary tumors. We also identified copy number gains (CNG) in several cell cycle genes, including: CCND1 (15.2%), CDK4 (2.7%), and AURKA (2.6%) (Table 1). Finally, further analyses at the transcript-level are the subject of on-going research. Conclusions: Our study highlights that there is substantial genomic heterogeneity among mutPIK3CA, HER2- a/mBCs. Across a series of comparisons between primary and metastatic samples, as well as HR+ and TNBC subtypes, we identified a number of co-mutations that occur alongside mutPIK3CA and which could be potentially exploited by targeted therapies. Future studies are needed to assess the prognostic/predictive role of these and other candidate gene alterations. Table 1. Genomic features of mutPIK3CA, HER2– a/mBCPrimaryMetastaticTotalAny PIK3CA Mutation1255527782mutPIK3CA2204425629HER2– (n=176)HER2– (n=370)546HR+ HER2– 154 (88%)TNBC 22 (12%)HR+ HER2– 337 (91%)TNBC 33 (9%)TMB-H16 (10.3%)2 (9.1%)41 (12%)4 (12%)63 (11.5%)MSI-H1 (0.6%)1 (4.5%)0 (0%)1 (3.0%)3 (0.5%)Co-mutations (mutPIK3CA): n (%)TP5347 (30.5%)14 (63.6%)101 (30%)27 (81.8%)189 (34.6%)CDH137 (24%)1 (4.5%)75 (22.3%)5 (15.2%)118 (21.6%)KMT2C17 (11%)1 (4.5%)40 (11.9%)2 (6.1%)60 (11%)MAP3K117 (11%)1 (4.5%)31 (9.2%)1 (3%)50 (9.2%)ARID1A15 (9.7%)0 (0%)26 (7.7%)2 (6.1%)43(7.9%)PTEN12 (7.8%)1 (4.5%)21 (6.2%)3 (9.1%)37 (6.8%)GATA311 (7.1%)0 (0%)23 (6.8%)2 (6.1%)35 (6.6%)TBX311 (7.1%)1 (4.5%)19 (5.6%)1 (3%)32 (5.9%)NCOR12 (1.3%)1 (4.5%)18 (5.3%)0 (0%)21 (3.8%)FOXA17 (4.5%)2 (9.1%)10 (3%)1 (3%)20 (3.7%)MAP2K41 (0.6%)1 (4.5%)12 (3.6%)1 (3%)15 (2.7%)ESR13 (1.9%)0 (0%)63 (18.7%)1 (3%)67 (12.3%)PIK3R13 (1.9%)0 (0%)4 (1.2%)0 (0%)7 (1.3%)AKT11 (0.6%)0 (0%)1 (0.6%)0 (0%)2 (0.4%)RB15 (3.2%)1 (4.5%)8 (2.4%)1 (3%)15 (2.7%)NF14 (2.6%)3 (13.6%)23 (6.8%)2 (6.1%)32 (5.9%)ERBB24 (2.6%)4 (18.2%)11 (3.3%)2 (6.1%)21 (3.8%)CCND1 CNG22 (14%)0 (0%)61 (18%)0 (0%)83 (15.2%)AURKA CNG3 (1.9%)0 (0%)11 (3.3%)0 (0%)14 (2.6%)CDK4 CNG5 (3.2%)1 (4.5%)7 (2.1%)1 (3.0%)14 (2.6%)1any somatic variant detected in PIK3CA2somatic PIK3CA mutations among the 11 currently included in the alpelisib companion diagnostic (C420R, E542K, E545A, E545D, E545G, E545K, Q546E, Q546R, H1047L, H1047R, and H1047Y) Citation Format: Jing Xi, Kathleen Harnden, Jingqin Luo, Greg S. Call, Elizabeth Mauer, Karyn Ronski, Cynthia X. Ma, Neil Vasan. Genomic landscape of HER2-negative advanced or metastatic breast cancer with PIK3CA gain-of-function mutations [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-09-04.
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2

Rodríguez-Arnao, J., G. Yarwood, C. Ferguson, J. Miell, C. J. Hinds, and R. J. M. Ross. "Reduction in circulating IGF-I and hepatic IGF-I mRNA levels after caecal ligation and puncture are associated with differential regulation of hepatic IGF-binding protein-1, -2 and -3 mRNA levels." Journal of Endocrinology 151, no. 2 (November 1996): 287–92. http://dx.doi.org/10.1677/joe.0.1510287.

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Abstract Sepsis is characterized by a severe shift in metabolism, characterized by low IGF-I levels. We have studied the influence of caecal ligation and puncture (CLP) on the levels of circulating IGF-I and hepatic IGF-I and IGF-binding protein (IGFBP)-1, -2 and -3 mRNA in adult male Wistar rats (n=12) and compared it with sham-operated rats (n=6). In order to exclude anorexia-induced changes we also studied animals pair-fed to both groups. IGF-I levels were measured by RIA. Steady-state hepatic IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 mRNA levels were measured by Northern blot analysis using specific rat cDNA probes. Food intake averaged 13·0 ± 2·0 g/day in the sham-operated rats fed ad libitum during the study period, with a sharp decline in food intake in the CLP animals (2·3 ± 1·3 g/day). After CLP, there was a significant reduction in circulating IGF-I levels (467·2 ± 50·9 μg/l) compared with sham-operated animals (924·0 ± 75·3 μg/l; P=0·04) or those pair-fed to the CLP rats (612·5 ± 52·9 μg/l; P=0·04). Total hepatic IGF-I mRNA levels were significantly reduced (2·57 ± 0·05 densitometric units (DU)) after CLP compared with the sham-operated group (2·71 ± 0·04; P=0·04), or their pair-fed controls (2·75 ± 0·08 DU; P<0·05). Hepatic IGFBP-3 mRNA levels were lower after CLP (0·37 ± 0·04 DU) than in the sham-operated animals (0·66 ± 0·09 DU; P=0·04) or their pair-fed controls (0·61 ± 0·05 DU; P=0·04). On the other hand, hepatic IGFBP-2 mRNA levels were increased after CLP (0·91 ± 0·11 DU) compared with sham-operated animals (0·28 ± 0·06 DU; P=0·01) or with their pair-fed controls (0·22 ± 0·22; P=0·01), as were hepatic IGFBP-1 mRNA levels (CLP animals 0·95 ± 0·11 DU; sham-operated 0·30 ± 0·04 DU, P=0·01; pair-fed 0·30 ± 0·02 DU, P=0·01). No significant difference between sham-operated animals and their pair-fed controls was observed in circulating IGF-I levels (888·0 ± 109·3 μg/l; P=not significant (N.S.)), hepatic mRNA levels for IGF-I (2·72 ± 0·06 DU; P=N.S), IGFBP-3 (0·71 ± 0·07 DU; P=N.S.), IGFBP-2 (0·25 ± 0·07 DU; P=N.S.) or IGFBP-1 (0·27 ± 0·06 DU; P=N.S.). In summary, after CLP there was a reduction in both circulating and hepatic IGF-I mRNA levels associated with a specific and differential regulation of hepatic IGFBP-1, -2 and -3 mRNA levels. Although we cannot eliminate a possible effect of surgical stress combined with malnutrition, our results suggest that these changes are a specific effect of sepsis rather than simply a result of surgical stress or poor nutrition alone. Journal of Endocrinology (1996) 151, 287–292
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3

Lawson, Lovett, Mohammed A. Yassin, Alex N. Onuoha, Andrew Ramsay, Rachel R. M. Anderson de Cuevas, Sally Theobald, Peter D. O. Davies, and Luis E. Cuevas. "Yield of Smear Microscopy and Radiological Findings of Male and Female Patients with Tuberculosis in Abuja, Nigeria." Tuberculosis Research and Treatment 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/241659.

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Objective. To describe the yield of smear-microscopy and radiological findings by male and female patients with symptoms of tuberculosis in Abuja, Nigeria.Methods. Patients ≥15 years old with cough for >3 weeks submitted 3 sputum samples for smear microscopy. One specimen was cultured using MGIT-960. All patients had lung X-rays and screened for HIV.Results. were more likely to be smear-positive than females (262/774 [34%] and 137/547 [25%],P<.01), but similar proportions of males and females were culture-positive (437/691 [63%] and 294/495 [59%],P=.09). 317/626 (50.6%) males and 249/419 (59.4%) females were HIV-positive (P<.005). Among culture-positives patients, HIV-infected males were less likely to have positive smears than HIV-negative males (49.2% versus 66%,P=.001). Among females, smear positivity did not vary with HIV (46.4% for HIV-positive and 52.9% for HIV-negative,P=.38). Of 274 culture-confirmed TB cases, 226 (82.5%) had cavities, and 271 (99%) had ≥1 lung areas affected. HIV-positive males were more likely to have lung cavities than HIV-positive females (85% versus 69%,P<.04) and to have ≥3 lung areas affected (P=.03).Conclusion. Differences in the yield of smear-microscopy, culture and X-rays on presentation are due to several factors including HIV coinfection and gender.
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4

Asiedu, F. H. K., and S. K. Karikari. "Energy and protein content and intake by stall-fed lambs of pure and mixed swards of Centrosema pubescens Benth., Pueraria phaseoloides Benth. and Brachiaria mutica Stapf. under a mango plantation." Journal of Agricultural Science 104, no. 1 (February 1985): 47–59. http://dx.doi.org/10.1017/s0021859600042970.

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SummaryPure and mixed swards of Centrosema pubescens (centro), Pueraria phaseoloides (puero) and Brachiaria mutica (para grass) established under a 12-year-old mango plantation were sampled at 6-week intervals for 2 years to determine crude-protein (CP) content, dry-matter (D.M.) and CP yields and apparent digestible energy and apparent digestible crude-protein (DCP) contents. Daily dry-matter intake (DMI) and apparent digestible energy and digestible crude-protein intakes (DEI and DCPI), as well as live-weight gain (LWG) by 11·5 kg penned West African cross-bred weaner lambs, were also determined.The pure legumes were better than the mixed swards in respect of CP (mean: 22·1, 18·8, 14·4 and 13·8% for centro, puero, centro-para grass and puero-para grass respectively) and DCP (mean: 16·2, 13·4, 10·4 and 10·0% respectively) contents, and daily DMI (mean: 50·8, 49·7, 41·8 and 41·3 g/kg W0·75 respectively), DEI (mean: 562, 531, 418 and 410 kj/kg W075 respectively) and DCPI (mean: 8·09, 6·55, 4·04 and 3·94 g/kg W0·75 respectively). On the other hand the legume-grass mixed swards, especially puero-para grass, were superior to the corresponding pure-legume swards with regard to D.M. yield (mean: 11·90, 7·69, 7·13 and 4·54 t/hafor puero-para grass, centro-para grass, puero and centro respectively) and CP yield(mean: 1·62,1·09, 1·32 and 0·99 t/ha respectively). The pure-legume stands gave the highest LWG per lamb (mean: 45·7, 3·89, 2·63 and 25·3 g/day for centro, puero, centro–para grass and puero-para grass respectively) but it was estimated that the legume-grass mixed swards would give higher returns in terms of lamb LWG on forages harvested per unit sward area than the corresponding pure-legume cover.It was concluded that legume-grass covers would be preferred to all-legume covers if livestock were to be integrated into tree crop farming systems. However, the choice of companion grass would have to be given proper consideration as shade-intolerant grass species, such as para grass, would detract from profit maximization.
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5

Le Cesne, Axel, Jean-Yves Blay, Binh Bui Nguyen, Olivier Bouche, Julien Domont, Angela Cioffi, Julie Le Boulicaut, Alain Moussy, Olivier Hermine, and Antoine Adenis. "Masitinib in imatinib-naive advanced gastrointestinal stromal tumor (GIST): Five-year follow-up of the French Sarcoma Group phase II trial." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 10089. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.10089.

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10089 Background: Masitinib is a tyrosine kinase inhibitor that in vitro has greater activity and selectivity than imatinib against KIT. This multicenter, open label, phase 2 study evaluated efficacy and safety of masitinib as a first-line treatment of advanced GIST. Initial results with a median follow-up of 34 months, were previously reported in EJC 2010. We present here 5-year follow-up data from the same series with updated safety and survival data. Methods: Imatinib-naïve patients (pts) with inoperable, advanced GIST received oral masitinib (7.5 mg/kg/day) until progression, refusal or toxicity. Results: Thirty pts with a median age of 58 years (60% of males) were included from 06/2005 to 04/2007 in 5 institutions. At the cut-off date of 13/09/2011, 7/30 pts (23%) were still under treatment with median follow-up of 65 months and the median overall survival (OS) had not yet been reached (NR). The 5-year OS rate was 61.5% (95% CI [41.1;76.6]) (see Table). Among patients with confirmed KIT exon 11 mutation, 8/9 pts (89%) were still alive with one pt having died from non-treatment related causes (surgical complication) following a complete response while receiving masitinib. No additional progressions have been reported giving a total of 14 events (13 progressions and 1 death). Updated median PFS was 41.3 months (95% CI [17.5;53.8]).No additional grade 3/4 adverse events have been reported. Conclusions: Long term results of masitinib confirm an interesting activity with prolonged PFS and OS. The median PFS rate in masitinib compares very favorably to that of imatinib, which is reported as 18 months (JCO 26:626, 2008). The 5-year OS rates for masitinib in the overall and exon 11 populations also compare favorably to imatinib, both of which are reported at ≤50% for imatinib (JCO 26:626, 2008; JCO 28:1247, 2010). These results support the head to head comparison with imatinib in the currently ongoing phase 3 randomized clinical trial in first line advanced GIST pts. [Table: see text]
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6

Gargallo, L., J. Vaamonde, R. Ibáñez, M. A. Del Real, A. Hernandez, and M. Gudín. "3-09-04 Early focal cerebral injury: Brain plasticity." Journal of the Neurological Sciences 150 (September 1997): S153. http://dx.doi.org/10.1016/s0022-510x(97)85595-5.

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7

Plekhanova, O., Y. Parfyonova, M. Solomatina, O. Viborov, P. Bashtrikov, A. Brooks, B. Berk, and V. Tkachuk. "M.621 Novel interplay of fibrinolytic system and oxidative stress in regulation of arterial remodelling." Atherosclerosis Supplements 5, no. 1 (April 2004): 144. http://dx.doi.org/10.1016/s1567-5688(04)90619-3.

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8

PLEKHANOVA, O. "M.621 Novel interplay of fibrinolytic system and oxidative stress in regulation of arterial remodelling." Atherosclerosis 5, no. 1 (April 2004): 144. http://dx.doi.org/10.1016/s0021-9150(04)90619-3.

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9

Roux, L., G. Thierry, E. Chazalon, R. Coste, S. Pommier, and F. Meyer. "621 La greffe de muqueuse palatine pour allonger la lamelle postérieure en paupière inférieure : à propos de quatre observations." Journal Français d'Ophtalmologie 32 (April 2009): 1S186. http://dx.doi.org/10.1016/s0181-5512(09)73745-3.

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10

Martinez de Posadas, M. del C., and H. Liste. "5-09-04 Children's neuromuscular diseases, (prevalence in neuromuscular section during 3 years)." Journal of the Neurological Sciences 150 (September 1997): S290. http://dx.doi.org/10.1016/s0022-510x(97)86303-4.

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11

Lucena, Rita, Irenio Gomes, and Ailton Melo. "4-04-09 Intra-hospital lethality of acute bacterial meningitis in children." Journal of the Neurological Sciences 150 (September 1997): S211. http://dx.doi.org/10.1016/s0022-510x(97)85892-3.

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12

Capitanio, U., A. Briganti, A. Gallina, N. Suardi, C. Jeldres, H. Isbarn, L. F. Da Pozzo, P. I. Karakiewicz, and F. Montorsi. "621 THE NUMBER OF BIOPSY CORES REPRESENTS ONE OF THE FOREMOST PREDICTOR OF CLINICALLY SIGNIFICANT GLEASON SUM UPGRADING IN LOW RISK PROSTATE CANCER PATIENTS." European Urology Supplements 8, no. 4 (March 2009): 276. http://dx.doi.org/10.1016/s1569-9056(09)60616-3.

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13

Moghaddasi, M., and M. Mamarabadi. "PO20-WE-04 Pseudo-internuclear ophthalmoplegia: a case report." Journal of the Neurological Sciences 285 (October 2009): S270. http://dx.doi.org/10.1016/s0022-510x(09)71026-3.

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14

Rivera-Pirela, Sergio E., Miriam Echeverría, Pedro Salcedo, Georgina Márquez, Zuhey Carrillo, Yennis Parra, Ana María Cipriani, José R. Núñez, and Melchor Álvarez de Mon. "HLA DRB1*, DQB1*, DPA1*, and DPB1* and their association with the pathogenesis of leukemia in the population of Venezuela." Revista Alergia México 63, no. 3 (August 27, 2016): 237. http://dx.doi.org/10.29262/ram.v63i3.147.

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Antecedentes: El complejo de histocompatibilidad es un factor que influye en la patogénesis de las leucemias.Objetivos: se evaluó la presencia de alelos HLA clase II DRB1*, DQB1*, DPA1* y DPB1* en 47 pacientes con leucemia linfoide aguda (LLA) y 48 con leucemia mieloide crónica (LMC), para compararlos con 48 voluntarios sanos de Zulia, Venezuela, y determinar las posibles asociaciones de HLA con las leucemias.Métodos: Se utilizó la técnica de PCR-SSP de baja y alta resolución para las regiones HLA clase II DRB1*, DQB1*, DPA1* y DPB1* conforme las instrucciones del KIT Olerup SSP Genovision.Resultados: Los alelos HLA-DRB1*14, especialmente DRB1*14:21, -DPA1*1:06, -DPA1*01:03,-DPA1*02:01, y los haplotipos HLA-DPA1*01:03-DPB1*04:01, DPA1*01:03-DPB1*02:01, DPA1*01:03-DPB1*99:01, -DRB1*14-DPA1*01:03, -DRB1*15-DPA1*01:03 tuvieron asociación con LMC (RR > 3); los alelos HLA-DRB1*13, -DQB1*02, -DPA1*01:05, -DPA1*01:09 y los haplotipos HLA-DPA1*01:09-DPB1*02:01, DPA1*01:09-DPB1*04:01 resultaron protectores (RR < 1). Los alelos HLA-DQB1*04, -DQB1*05, -DPA1*1:06, -DPA1*01:07, -DPA1*1:08 tuvieron asociación positiva con LLA. Los alelos HLA-DPA1*01:09, -DPA1*02:01, -DPB1*02:01, -DPB1*03:01 y los haplotipos HLA-DPA1*01:03-DPB1*04:02, -DPA1*01:09-DPB1*02:01, -DPA1*01:09-DPB1*04:01, -DPA1*02:01-DPB1*04:02 resultaron asociados negativamente.Conclusiones: La ausencia de asociaciones con la región HLA-DRB1* en LLA y los otros patrones de asociación identificados sugieren marcadas diferencias en las patogénesis de las leucemias, lo que orienta hacia posibles deficiencias en la presentación antigénica para LLA o posibles efectos de mimetismo molecular en LMC.
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15

Lee, Christopher K. C. "CS11-04 Sustaining First-line Antiretroviral Regimens: The Third World Experience." International Journal of Infectious Diseases 13 (August 2009): S15. http://dx.doi.org/10.1016/s1201-9712(09)60287-3.

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16

Bergsholm, Einar. "Trær på naboeiendom – forholdet mellom naboloven § 3 og § 2." Lov og Rett 42, no. 09 (October 7, 2003): 557–68. http://dx.doi.org/10.18261/issn1504-3061-2003-09-04.

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17

Lin, Shoo-Lin, Pei-Jung Lu, Wei-Chun Huang, Kuan-Ran Chiou, and Chun-Peng Liu. "P3-09 Effect of ultrasonic contrast agent in the enhancement of gene transfection." International Journal of Cardiology 97 (January 2004): S53. http://dx.doi.org/10.1016/s0167-5273(04)80177-3.

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18

Binte Shahab Syed, Hamd, M. Yunus Khan, and Ruqqia Shafi Minhas. "Teratogenic Effect of Sodium Phenytoin on Limb Development in Chick Embryos is Time-Mediated as Evident by Stereomicroscope." Journal of Islamabad Medical & Dental College 8, no. 2 (June 27, 2019): 60–64. http://dx.doi.org/10.35787/jimdc.v8i2.356.

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Background: Women suffering from seizure-related illnesses are prescribed phenytoin during pregnancy if the benefits outweigh the risks. But the teratogenic effect of this drug on limb development needs exploration. This study was designed to investigate the time-mediated teratogenic effect of sodium phenytoin on limb development of chick embryos on days 04 and 09 of development using the stereomicroscope and at the time of hatching. Material and Methods: This randomized control trial comprised of two main groups of fertilized chicken eggs (Egyptian Fayoumi breed), control group A and experimental group B, each having 90 eggs. Each experimental egg was injected with sodium phenytoin (3.5 mg, teratogenic dose) just before incubation. Both the groups were divided into three subgroups each A1, A2, & A3/B1, B2 & B3. Stereomicroscope was used to observe the limb buds and cartilaginous elements in subgroups 1 and 2 on days 04 and 09 of development respectively. The embryos of subgroups 3 were assessed for gross limb deformities on hatching. Survival was noted in all the subgroups.Results: The difference in limb bud size between experimental and controls was statistically insignificant. There was no variation or deformity in the bones. The experimental group 3 had gross limb defects on hatching and the difference in survival was also statistically significant in subgroups 3.Conclusion: Prenatal administration of sodium phenytoin induces limb defects in chick embryos as evident after hatching but limb anomalies are not observed on days 04 and 09 of development as investigated by stereomicroscope. We conclude that the teratogenic effect of phenytoin is time-mediated.
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19

Wang, Rui, Mingxiao Yang, Iris Zhi, and Ting Bao. "Abstract P1-09-04: Flaxseed & breast cancer: A systematic review." Cancer Research 82, no. 4_Supplement (February 15, 2022): P1–09–04—P1–09–04. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-09-04.

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Abstract Background: Flaxseed has been extensively studied in in vitro and in vivo models for possible association with reducing the risk of breast cancer. Clinical trials have been limited. There has been confusion regarding whether it is safe and beneficial for breast cancer survivors to take flaxseed. Therefore, we conducted a systematic review to evaluate the existing randomized controlled trial to understand the safety and efficacy of using flaxseed for symptom control and reducing the risk of recurrence among breast cancer survivors. Patients and Methods: We conducted a literature search of English language publications in MEDLINE, EMBASE, and Cochrane from the databases’ inception to May 2021 using the keywords flaxseed, breast cancer, randomized clinical trial, and human studies. Results: We identified three randomized controlled trials (RCT) that include patients with a history of breast cancer. Sample size ranged from 24 to 178 patients and treatment duration ranged from 13 to 42 days. The primary end points were hot flash severity (one study) and tumor biomarkers (two studies). There was no statistically significant reduction in mean hot flash score in the flaxseed group compared to the placebo group. One study showed a statistically significant reduction in Ki-67 (34.2%; P=0.001) and in c-erbB2 expression (71.0%; P=0.003), and an increase in apoptosis (30.7%; P=0.007) in the group that received flaxseed, but not in the placebo group. On the contrary, another study showed no difference in Ki-67, caspase, the Ki-67/caspase ratio, and Estrogen-receptor β. Two studies reported mild adverse events as shown in Table 1. None of the studies assessed the change in estrogen level. Risk of bias assessment showed that the overall risk of bias associated with the included studies is moderate to high. The high risk of bias originates from lack of blinding of participants and personnel. Conclusion: Current clinical research in breast cancer survivors is too limited to recommend flaxseed for cancer prevention. Flaxseed appears to be safe with mild side effects, however, the effect of flaxseed on estrogen concentration has not been established. Table 1.Characteristics of included studies and risk of bias assessmentIDBreast cancer participantsSample sizeExperimentalControlOutcomesAdverse eventsRisk of biasPruthi 2012(U.S.)With breast cancer: (Yes/No)Flaxseed: 44/88Placebo: 47/90Flaxseed: 88Placebo: 90Flaxseed bar: 7.5g of flaxseed, 200 calories, one bar daily, 6 weeksPlacebo bar: 2g protein, 20% fiber, 200 calories, one bar daily, 6 weeksFrequency and severity of hot flash; hot flash interference; the Profile of Mood States; the Menopause Quality of Life Scale; the Global Impression of BenefitAbdominal distension and pain, diarrhea, flatulence, nausea, pruritus, maculopapular rash, vomitingLowThompson 2005(Canada)Flaxseed: (ER+ & PR+) 17/19; (ER- OR PR-) 2/19Placebo: (ER+ & PR+) 11/13; (ER- OR PR-) 2/13Flaxseed: 19Placebo: 13Flaxseed muffin: 25g flaxseed + 20.7g white wheat flour, one daily, 32 daysPlacebo muffin: 20.7g whole wheat flour+10g canola oil, one daily, 39 daysBreast cancer biomarkers including Ki-67, apoptosis, C-erbB2, ER and PR scoresAbdominal fullness and increased bowel movementsSome concernMcCann 2014(Canada)Clinical stage: Flaxseed: I 4/6; IIA 1/6; IIB 1/6;Anastrozole: I 6/7; IIA 1/7;Flaxseed/Anastrozole: I 5/6; IIA 1/6;Placebo: I 3/5; IIA 2/5Flaxseed: 6;Anastrozole: 7;Flaxseed/Anastrozole: 6;Placebo: I5;Flaxseed: 25 g/d ground flaxseed + 1/d placebo pill, 13-16 daysAnastrozole: 1 mg/d;Flaxseed/Anastrazole: 25 g/d ground flaxseed + 1 mg/d Anastrozole;Placebo: 1/d; 13-16 daysBreast cancer biomarkers including Ki-67, caspase, the Ki-67/caspase ratio, and Estrogen-receptor βNot reportedHigh Citation Format: Rui Wang, Mingxiao Yang, Iris Zhi, Ting Bao. Flaxseed & breast cancer: A systematic review [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-09-04.
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20

Viale, Giuseppe, Leen Slaets, Femke De Snoo, Laura J. van 't Veer, Emiel J. Rutgers, Martine J. Piccart-Gebhart, Jan Bogaerts, et al. "Comparison of molecular (BluePrint+MammaPrint) and pathological subtypes for breast cancer among the first 800 patients from the EORTC 10041/BIG 3-04 (MINDACT) trial." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 1022. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.1022.

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1022 Background: Biology has become the main driver of breast cancer therapy. Intrinsic biological subtypes by gene expression profiling have been identified. Pathology can be used to define surrogates of these subtypes but these are not always concordant, which may lead to different treatment plans. We investigated the concordance between BluePrint (BP) + MammaPrint (MP) (micro array based) breast cancer subtypes and pathological surrogates (based on ER, PR, HER2, and Ki67). Contrary to the Perou gene set (evolved into PAM50), BluePrint was trained using pathological data. Methods: Using available data (centrally assessed pathology and genomic) from the MINDACT pilot phase (Rutgers et al 2011) 621 tumors were analyzed. Two pathology classifications were used: one with 4 categories and one with 5 categories (Goldhirsch et al 2011). Based on BP 3 subtypes are formed: Luminal, HER2 and Basal. The Luminal subtype is further split into Luminal A (MP low risk) and Luminal B (MP high risk). Results: See table. Conclusions: All pathological Basal cases are BP Basal, apart from 1 BP HER2 case. Of the BP Basal cases, 15 are not pathological Basal: 1 is Luminal A, 11 are Luminal B (of which 8 are IHC ER/PR borderline (≥1% and < 10%)) and 3 are HER2. All pathological Luminal (A & B) that are BP HER2 are HER2- by TargetPrint. 25 of the 26 pathological HER2+ that are BP Luminal A are ER+. Most discordant cases are seen within the Luminal subtype, indicating that Ki67 discriminates Luminal A vs. B differently than MammaPrint does. The observed subtype discrepancies reveal potential important impact for treatment-decision making. MINDACT will provide important information. [Table: see text]
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21

Deepak, A., S. Sanjeev, and M. R. Sivakumar. "FP01-MO-04 Use of transcranial Doppler for the detection of severe carotid stenosis." Journal of the Neurological Sciences 285 (October 2009): S58. http://dx.doi.org/10.1016/s0022-510x(09)70264-3.

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22

Demirkaya, S., M. Terzi, G. Genç, T. Kaşıkçı, and Z. Odabaşı. "FP17-TU-04 CSF oligoclonal band as a marker for prognosis in multiple sclerosis." Journal of the Neurological Sciences 285 (October 2009): S84. http://dx.doi.org/10.1016/s0022-510x(09)70353-3.

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23

Singhal, A. B., R. A. Hajj-Ali, and L. H. Calabrese. "FP27-TU-04 Reversible cerebral vasoconstriction syndromes (RCVS) - two center experience of 139 cases." Journal of the Neurological Sciences 285 (October 2009): S100—S101. http://dx.doi.org/10.1016/s0022-510x(09)70411-3.

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24

Oliveira, Antônio Régis de, Sebastião A. de Oliveira, Leonardo de B. Giordano, and Wenceslau J. Goedert. "Absorção de nutrientes e resposta à adubação em linhagens de tomateiro." Horticultura Brasileira 27, no. 4 (December 2009): 498–504. http://dx.doi.org/10.1590/s0102-05362009000400016.

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Vinte e nove linhagens de tomateiro rasteiro foram avaliadas quanto à eficiência de absorção de nutrientes e resposta à adubação, em dois ensaios, no ano de 2006, na Embrapa Hortaliças. No primeiro ensaio aplicou-se 1/3 da dosagem de fertilizante utilizada no segundo. O delineamento experimental foi inteiramente casualizado, com três repetições. As linhagens foram classificadas quanto à eficiência na absorção de nutrientes e reposta à adubação baseando-se nos incrementos de índice DRIS e nos incrementos de produtividade. Os valores críticos para eficiência na absorção e resposta à adubação foram as médias de incremento de índice DRIS e produtividade, respectivamente. As linhagens diferenciaram-se quanto à eficiência na absorção dos nutrientes e quanto à resposta à adubação. Foram consideradas responsivas à adubação e eficientes na absorção de nutrientes as linhagens 03, 04, 05, 09 e 22, para o N; 03, 04, 09, 13, 15 e 29, para o P; 03, 05, 10, 21, 22, 25 e 27, para o K; 05, 10, 21, 22, 25, 27 e 29, para o Ca; 04, 13, 15, 27 e 29, para o S e B; e 03, 05, 09, 10 e 27, para o Cu. As linhagens com os melhores desempenhos foram a 27, na absorção dos nutrientes, e 03, 04, 05 e 29, na responsividade à adubação.
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25

Viale, Giuseppe, Leen Slaets, Femke De Snoo, Laura J. van 't Veer, Emiel J. Rutgers, Jan Bogaerts, Lisette Stork-Sloots, et al. "Comparison of molecular (BluePrint and MammaPrint) and pathological subtypes for breast cancer among the first 800 patients from the EORTC 10041/BIG 3-04 (MINDACT) trial." Journal of Clinical Oncology 30, no. 27_suppl (September 20, 2012): 32. http://dx.doi.org/10.1200/jco.2012.30.27_suppl.32.

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32 Background: Biology has become the main driver of breast cancer therapy. Intrinsic biological subtypes by gene expression profiling have been identified. Pathology can be used to define surrogates of these subtypes but these are not always concordant, which may lead to different treatment plans. We investigated the concordance between BluePrint (BP) + MammaPrint (MP) (micro array based) breast cancer subtypes and pathological surrogates (based on ER, PR, HER2 and Ki67). Contrary to the Perou gene set (evolved into PAM50), BluePrint was trained using pathological data. Methods: Using available data (centrally assessed pathology and genomic) from the MINDACT pilot phase (Rutgers et al 2011) 621 tumors were analyzed. Two pathology classifications were used: one with 4 categories and one with 5 categories (Goldhirsch et al 2011). Based on BP 3 subtypes are formed: Luminal, HER2 and Basal. The Luminal subtype is further split into Luminal A (MP low risk) and Luminal B (MP high risk). Results: See table. Conclusions: All pathological Basal cases are BP Basal, apart from 1 BP HER2 case. Of the BP Basal cases, 15 are not pathological Basal: 1 is Luminal A, 11 are Luminal B (of which 8 are IHC ER/PR borderline (≥1% and < 10%)) and 3 are HER2. All pathological Luminal (A & B) that are BP HER2 are HER2- by TargetPrint. 25 of the 26 pathological HER2+ that are BP Luminal A are ER+. Most discordant cases are seen within the Luminal subtype, indicating that Ki67 discriminates Luminal A vs. B differently than MammaPrint does. The observed subtype discrepancies reveal potential important impact for treatment-decision making. MINDACT will provide important information. [Table: see text]
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26

Wiemer, E., P. Schenk, M. Brok, A. Boersma, M. van Rijnsoever, N. Zeps, B. Iacopetta, and K. Nooter. "621 Disruption of the serine kinase SKY1 gene in yeast results in hypersensitivity to 5-fluorouracil (5-FU) and low expression of the human SKY1 ortholog SRPK1, in colorectal cancers correlates with prolonged overall survival after 5-FU treatment." European Journal of Cancer Supplements 2, no. 8 (September 2004): 188. http://dx.doi.org/10.1016/s1359-6349(04)80629-3.

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27

Bhidayasiri, R., C. Chotipanich, S. Chiewvit, and S. Tepmongkol. "FP41-TH-04 Striatal dopaminergic activity (FDOPA-PET) in retired Thai male boxers with pugilistic Parkinsonism." Journal of the Neurological Sciences 285 (October 2009): S123. http://dx.doi.org/10.1016/s0022-510x(09)70487-3.

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28

Novick, D., A. Gonzalez-Pinto, J. M. Haro, J. Bertsch, C. Reed, E. Perrin, and M. Tohen. "Translation of Randomised Controlled Trial Findings into Clinical Practice: Comparison of Olanzapine and Valproate in the Emblem Study." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70547-4.

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Aims:To contrast the outcomes of olanzapine- and valproate-treated patients in an observational study of acute mania with the results of a RCT assessing the same treatments (Tohen et al., 2002).Methods:EMBLEM (European Mania in Bipolar Evaluation of Medication) was a 2-year, prospective, observational study of health outcomes associated with treatment of mania. Severity of mania and depression was assessed at baseline and 6 weeks using the YMRS and 5-item version of the HAMD, respectively. The RCT was a 3-week, randomised, double-blind comparison of olanzapine (n=125) and divalproate-treated (n=123) patients hospitalised for acute manic or mixed episodes. The YMRS and HAMD were used to quantify manic and depressive symptoms, respectively.Results:621 EMBLEM patients were analysed (n=107 valproate, n=514 olanzapine). Both observed groups improved from baseline to 6 weeks in mean YMRS and HAMD-5 total scores, with significantly greater mean improvements in the olanzapine compared with the valproate group using linear regression to adjust for baseline differences. The RCT reported significantly greater mean YMRS improvement (but not HAMD) in the olanzapine-treated group. EMBLEM patients treated with olanzapine experienced significantly greater weight gain than patients treated with valproate, similar to RCT results. There was a significantly greater incidence of treatment-emergent gastrointestinal adverse events in EMBLEM patients treated with valproate.Conclusions:The EMBLEM results support those of the RCT, which suggest that olanzapine monotherapy may be more effective than valproate monotherapy in the treatment of acute mania. Contrasting observational and RCT results present methodological challenges but can provide important complementary information.
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29

Aas, Maria B. "Legalisering av ureturnerbare utlendingers opphold i Norge – Hensiktsmessighet og statens forpliktelser etter EMK artikkel 3." Kritisk juss 32, no. 04 (March 20, 2017): 383–92. http://dx.doi.org/10.18261/issn2387-4546-2006-04-09.

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30

Jeiranashvili, A., M. Khachiashvili, N. Lobjanidze, M. Janelidze, L. Bakradze, I. Toidze, and A. Dzagnidze. "FP55-FR-04 Low back pain due to herniated lumbar disc: comparison of early and late surgical treatment." Journal of the Neurological Sciences 285 (October 2009): S145. http://dx.doi.org/10.1016/s0022-510x(09)70562-3.

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31

Tabish, T. T. L., S. N. N. Noureen, M. S. Z. Syeda, A. M. Abdul, and F. S. K. Khan. "PO09-MO-04 Incidence of speech language problems in an OPD of a Tertiary Care Hospital of Karachi." Journal of the Neurological Sciences 285 (October 2009): S192—S193. http://dx.doi.org/10.1016/s0022-510x(09)70740-3.

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32

Qolbi, A'yun, and Raditya Sukmana. "DETERMINAN NIATAN MAHASISWA TERHADAP WAKAF TUNAI SECARA ONLINE MENGGUNAKAN MODIFIKASI TECHNOLOGY ACCEPTANCE MODEL." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 1 (January 30, 2022): 78. http://dx.doi.org/10.20473/vol9iss20221pp78-91.

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ABSTRAKTujuan dari Penelitian ini adalah menguji pengaruh kepercayaan dan citra website yang diintegrasikan dengan persepsi kemudahan penggunaan dan persepsi kebermanfaatan pada niatan seorang mahasiswa dalam membayar wakaf secara online, yang menjadikan penelitian ini berbeda dengan penelitian sebelumnya adalah penggunaan citra website sebagai determinan niatan mahasiswa dalam menggunakan layanan wakaf online ini. Penelitian ini menggunakan pendekatan kuantitatif dengan metode SEM-PLS serta melibatkan responden sebesar 100 responden dengan menggunakan Purposive Sampling dengan kriteria seorang muslim usia 18-35 dan seorang mahasiswa. Software analisis untuk mengolah data dalam penelitian ini menggunakan Smartpls 3.3, untuk data diperoleh dengan menggunakan kuesioner online menggunakan skala likert 1 sampai 5, dengan keterangan sangat setuju hingga tidak setuju. Hasil dari penelitian ini menunjukkan bahwa kepercayaan, citra website, kebermanfaatan aplikasi, dan kemudahan penggunaan berhubungan signifikan terhadap niat penggunaan wakaf online. Implikasi hasil penelitian ini diharapkan dapat memberikan tambahan pengetahuan terutama dalam ilmu pemasaran Islam terkait penggunaan behavioral intention dalam penggunaan layanan wakaf online, serta diharapkan penelitian ini dapat memberikan masukan bagi manajemen lembaga donasi terutama nazir untuk lebih memperhatikan kemudahan penggunaan konsumen, manfaat yang dirasakan, kepercayaan lembaga, citra perusahaan serta niat dalam menggunakan layanan wakaf secara online.Kata kunci: Wakaf online, technology acceptance model, trust, image. ABSTRACTThe purpose of this study was to examine the effect of trust and website image, which is integrated with perceived ease of use and perceived usefulness, on a student's intention to pay waqf online. What makes this research different from previous research is using website images to determine student intention in using this online waqf service. This study uses a quantitative approach with the SEM-PLS method and involves 100 respondents using purposive sampling with the criteria of a Muslim aged 18-35 and a student. The analysis software to process data in this study used Smartpls 3.3 for data obtained using an online questionnaire using a Likert scale of 1 to 5, with statements strongly agreeing to disagree. This study indicates that trust, website image, application usefulness, and ease of use are significantly related to the intention to use online waqf. The implications of the results of this study are expected to provide additional knowledge, especially in Islamic marketing related to the use of behavioral intention in the use of online waqf services. It is hoped that this research can provide input for the management of donation institutions, especially Nazir, to pay more attention to consumers' ease of use, perceived benefits, and institutional trust., corporate image and intention to use online waqf services.Keywords: online waqf, technology acceptance model, trust, image. DAFTAR PUSTAKAAbdul Shukor, S., Johari, F., Abd Wahab, K., Kefeli Zulkefli, Z., Ahmad, N., Haji Alias, M., Abdul Rahman, A., Mohd Orip, N. M., Ibrahim, P., & Abu-Hussin, M. F. (2019). Trust on awqaf institutions: evidence from Malaysia. Journal of Islamic Marketing, 10(2), 511–524. https://doi.org/10.1108/JIMA-05-2017-0054Ahn, J. chang, Sura, S., & An, J. C. (2018). Intention to donate via social network sites (SNSs): A comparison study between Malaysian and South Korean users. Information Technology and People, 31(4), 910–926. https://doi.org/10.1108/ITP-12-2015-0307Aldeen, K. N., Ratih, I. S., & Herianingrum, S. (2020). Contemporary issues on cash waqf: A thematic literature review. International Journal of Islamic Economics and Finance (IJIEF), 3(3), 119–144. https://doi.org/10.18196/ijief.3236Alrubaiee, L. S., Aladwan, S., Abu Joma, M. H., Idris, W. M., & Khater, S. (2017). Relationship between corporate social responsibility and marketing performance: The mediating effect of customer value and corporate image. International Business Research, 10(2), 104. https://doi.org/10.5539/ibr.v10n2p104Bailey, A. A., Pentina, I., Mishra, A. S., & Ben Mimoun, M. S. (2017). Mobile payments adoption by US consumers: An extended TAM. International Journal of Retail and Distribution Management, 45(6), 626–640. https://doi.org/10.1108/IJRDM-08-2016-0144Berakon, I., Aji, H. M., & Hafizi, M. R. (2021). Impact of digital sharia banking systems on cash-waqf among Indonesian Muslim youth. Journal of Islamic Marketing. https://doi.org/10.1108/JIMA-11-2020-0337Blagoeva, K. T., & Mijoska, M. (2017). Applying TAM to study online shopping adoption among youth in the republic of Macedonia. Genetika, 46(3), 27–32.Eneizan, B., Alsaad, A., Alkhawaldeh, A., Rawash, H. N., & Enaizan, O. (2020). E-WOM, trust, usefulness, ease of use, and online shopping via websites: The moderating role of online shopping experience. Journal of Theoretical and Applied Information Technology, 98(13), 2554–2565.Faisal, M., Yusof, M., Alam, S., Faiz, M., Yusof, M., Alam, S., Hasarudin, M. H., Alam, S., Romli, N., Lumpur, K., Terms, G., & Statement, P. (2014). Cash waqf and infaq: A proposed e-philanthropy in Malaysia. Jurnal Kemanusiaan, 12(1), 1–10.Hair Jr., J. F., Gabriel, M. L. D. da S., & Patel, V. K. (2014). Modelagem de equações estruturais baseada em covariância (CB-SEM) com o AMOS: Orientações sobre a sua aplicação como uma Ferramenta de Pesquisa de Marketing. Revista Brasileira de Marketing, 13(2), 44–55. https://doi.org/10.5585/remark.v13i2.2718Indahsari, K., Burhan, M. U., Ashar, K., & Multifiah. (2014). Determinants of individual Muslim behaviour in accomplishing zakah, infaq, shadaqah and waqf through amil institution. International Journal of Economic Policy in Emerging Economies, 7(4), 346–365. https://doi.org/10.1504/IJEPEE.2014.066627Iskandar, M., Hartoyo, H., & Hermadi, I. (2020). Analysis of factors affecting behavioral intention and use of behavioral of mobile banking using unified theory of acceptance and use of technology 2 model approach. International Review of Management and Marketing, 10(2), 41–49. https://doi.org/10.32479/irmm.9292Joseph, S. (2014). Waqf in historical perspective: Online fatāwā and contemporary discourses by muslim scholars. Journal of Muslim Minority Affairs, 34(4), 425–437. https://doi.org/10.1080/13602004.2014.965974Kasri, R. A., & Chaerunnisa, S. R. (2021). The role of knowledge, trust, and religiosity in explaining the online cash waqf amongst Muslim millennials. Journal of Islamic Marketing. https://doi.org/10.1108/JIMA-04-2020-0101Klopping, I. M., & Mckinney, E. (2004). Extending the technology acceptance model and the task-technology fit model to consumer e-commerce. Information Technology, Learning, and Performance Journal, 22(1), 35–48.Lubis, H. (2020). Potensi dan strategi pengembangan wakaf uang di indonesia. IBF: Islamic Business and Finance, 1(1), 43–59.Masrikhan, M. (2019). Optimalisasi potensi wakaf di era digital melalui platform online wakafin.com dengan konsep crowdfunding sebagai penggerak ekonomi masyarakat. Jurnal Ekonomi Syariah, 1, 1–12.Mohd Thas Thaker, M. A. Bin. (2018). Factors influencing the adoption of the crowdfunding-waqf model (CWM) in the waqf land development. Journal of Islamic Marketing, 9(3), 578–597. https://doi.org/10.1108/JIMA-05-2016-0043Mohd Thas Thaker, M. A., Mohd Thas Thaker, H., A.Pitchay, A., & Khaliq, A. (2019). A proposed integrated zakat-crowdfunding model (IZCM) for effective collection and distribution of zakat fund in Malaysia. International Journal of Zakat and Islamic Philanthropy, 1(2), 1–12.Niswah, F. M., Mutmainah, L., & Legowati, D. A. (2019). Muslim millennial’s intention of donating for charity using fintech platform. Journal of Islamic Monetary Economics and Finance, 5(3), 623–644. https://doi.org/10.21098/jimf.v5i3.1080Nour Aldeen, K., Ratih, I. S., & Sari Pertiwi, R. (2021). Cash waqf from the millennials’ perspective: a case of Indonesia. ISRA International Journal of Islamic Finance, ahead-of-p(ahead-of-print). https://doi.org/10.1108/ijif-10-2020-0223Phatthana, W., & Mat, N. K. N. (2011). The application of technology acceptance model (TAM) on health tourism e-purchase intention predictors in Thailand. 2010 International Conference on Business and Economics Research, 1, 196–199. http://www.ipedr.com/vol1/43-B10046.pdfRaza, S. A., Shah, N., & Ali, M. (2019). Acceptance of mobile banking in Islamic banks: Evidence from modified UTAUT model. Journal of Islamic Marketing, 10(1), 357–376. https://doi.org/10.1108/JIMA-04-2017-0038Rybaczewska, M., Sparks, L., & Sułkowski, Ł. (2020). Consumers’ purchase decisions and employer image. Journal of Retailing and Consumer Services, 55(October 2019), 0–7. https://doi.org/10.1016/j.jretconser.2020.102123Sabri, F. A. (2014). Wakaf uang (Sebuah alternatif dalam upaya menyejahterakan masyarakat). AL-IHKAM: Jurnal Hukum & Pranata Sosial, 8(1), 40–54. https://doi.org/10.19105/al-lhkam.v8i1.339Shaikh, I. M., Qureshi, M. A., Noordin, K., Shaikh, J. M., Khan, A., & Shahbaz, M. S. (2020). Acceptance of Islamic financial technology (FinTech) banking services by Malaysian users: An extension of technology acceptance model. Foresight, 22(3), 367–383. https://doi.org/10.1108/FS-12-2019-0105Singh, S., Sahni, M. M., & Kovid, R. K. (2020). What drives fintech adoption? A multi-method evaluation using an adapted technology acceptance model. Management Decision, 58(8), 1675–1697. https://doi.org/10.1108/MD-09-2019-1318Sohn, S. (2017). A contextual perspective on consumers’ perceived usefulness: The case of mobile online shopping. Journal of Retailing and Consumer Services, 38(May), 22–33. https://doi.org/10.1016/j.jretconser.2017.05.002Usman, H., Mulia, D., Chairy, C., & Widowati, N. (2020). Integrating trust, religiosity and image into technology acceptance model: the case of the Islamic philanthropy in Indonesia. Journal of Islamic Marketing. https://doi.org/10.1108/JIMA-01-2020-0020Victoria, O. A., Pujirahayu, E. W., Khisni, A., & Ong, R. (2019). Law development of waqf al-nuqud (Cash waqf) towards electronic waqf (E-waqf) based on public welfare. LDJ: Law Development Journal, 1(1), 13–17.Wadi, D. A., & Nurzaman, M. S. (2020). Millennials behaviour towards digital waqf innovation. International Journal of Islamic Economics and Finance (IJIEF), 3(3), 1–30. https://doi.org/10.18196/ijief.3232Wong, K. K. K.-K. (2013). Partial least squares structural equation modeling (PLS-SEM) techniques using SmartPLS. Marketing Bulletin, 24(1), 1–32. Retrieved from http://marketing-bulletin.massey.ac.nz/v24/mb_v24_t1_wong.pdf%5Cnhttp://www.researchgate.net/profile/Ken_Wong10/publication/268449353_Partial_Least_Squares_Structural_Equation_Modeling_(PLS-SEM)_Techniques_Using_SmartPLS/links/54773b1b0cf293e2da25e3f3.pdfZhang, E. M. (2010). Understanding the acceptance of mobile SMS advertising among young chinese consumers. Psychology & Marketing, 30(6), 461–469. https://doi.org/10.1002/mar
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Herzig, R., I. Vlachova, D. Kamaradova, J. Mares, D. Novotny, J. Rusek, D. Sanak, et al. "FP08-MO-04 Occurrence of chronic alcohol intake in patients with acute ischemic stroke: a carbohydrate-deficient transferrin study." Journal of the Neurological Sciences 285 (October 2009): S70. http://dx.doi.org/10.1016/s0022-510x(09)70305-3.

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34

Hyde, R., C. Bozic, G. Belcher, T. Dong-Si, R. Kim, F. Lynn, M. Kooijmans-Coutinho, and M. A. Panzara. "FP33-WE-04 Utilization and safety of natalizumab in patients with relapsing multiple sclerosis in the post-marketing setting." Journal of the Neurological Sciences 285 (October 2009): S110. http://dx.doi.org/10.1016/s0022-510x(09)70442-3.

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35

Elbel, Daniel. "Anonyme Geburten und Babyklappen – Zum Gesetzesentwurf des Bundesrats vom 13. 09. 2004 (BR-Drucks. 682/04) zur Regelung anonymer Geburten." Kritische Vierteljahresschrift für Gesetzgebung und Rechtswissenschaft 90, no. 3 (2007): 293–309. http://dx.doi.org/10.5771/2193-7869-2007-3-293.

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36

Suvorova, Tatyana Alexandrovna, and Alexander Vladimirovich German. "The composition of the leukocytes of the bream of the Saratov reservoir." Rybovodstvo i rybnoe hozjajstvo (Fish Breeding and Fisheries), no. 2 (February 1, 2021): 44–51. http://dx.doi.org/10.33920/sel-09-2102-04.

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The composition of leukocytes reflects the species and ecological characteristics of fish, while the ratio of individual cell types reflects the functional state of the organism and the nature of the influence of biotic and abiotic stress factors. The work is devoted to the issues of hematopoiesis of the bream Abramis brama — one of the main commercial species of the Volga. The fish were caught in September 2019 at the Saratov Reservoir during a complex hydrobiological expedition aboard the Akademik Topchiev research vessel of the IBIW RAS. In total, 18 sexually mature bream were examined, caught at 3 standard trawling stations: 1 — Shirokiy Buerak, 2 — Khvalynsk, 3 — Kashpir-Rudnik. In fish, peripheral blood was sampled from the tail vein and tissues of the spleen and head kidney. Blood smears and organ imprint smears were performed for the study. The preparations were examined under a light microscope and the leukocyte formula was determined. To determine the index of the abundance of leukocytes in a peripheral blood smear, 100 visual fields were examined at different sites. The leukocyte abundance index allows the intensity of leukopoiesis to be recorded and indirectly assesses the leukocyte level in a blood volume unit. The results of the study showed that lymphocytes predominate in the leukocyte formula, a significant part are blast forms and a small percentage of granulocytes and monocytes/macrophages. The established differences depended on the structural and functional features of the organs: in the kidneys, as the main organ of hematopoiesisin teleost fish, a higher content of blast forms of cells, granulocytes and macrophages was noted, and in the spleen, which serves as a “depot” of blood, lymphocytes and macrophages. Blood, as an integral system, bears all types of cells circulating in the immune system at the moment. The intensity of leukopoiesis was higher in fish from the upper part of the reservoir.
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37

Gironi, M., A. Russo, A. Bianchi, M. Alberoni, E. Farina, A. Angelini, M. Cursano, et al. "FP49-TH-04 Oxidative and antioxidant markers in patients with neurodegenerative diseases: a pilot study to estimate risk and protective factors." Journal of the Neurological Sciences 285 (October 2009): S136. http://dx.doi.org/10.1016/s0022-510x(09)70531-3.

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38

Munibari, M. M. A. "PO16-TU-04 Congenital anomalies of the nervous system among children up to five years old of parents with consanguineous marriages." Journal of the Neurological Sciences 285 (October 2009): S236. http://dx.doi.org/10.1016/s0022-510x(09)70901-3.

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39

Cordonnier, C., H. Einsele, M. Rovira, J. Maertens, C. Faucher, E. Olavarria, and P. Ljungman. "D-04 Voriconazole (VORI) en prophylaxie secondaire des infections fongiques invasives (IFI) après allogreffe de cellules souches hématopoïétiques (CSH) : étude VOSIFI." Médecine et Maladies Infectieuses 39 (June 2009): S30. http://dx.doi.org/10.1016/s0399-077x(09)74351-3.

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40

Kamran, Muhammad, Irfan Ullah, and Muhammad Kaleem. "EXPLORING RIGHT TO INFORMATION AND GOOD GOVERNANCE IN PAKISTAN: A SOCIOLOGICAL PERSPECTIVE." DECEMBER 37, no. 04 (December 31, 2021): 469–84. http://dx.doi.org/10.51380/gujr-37-04-09.

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Анотація:
The study attempted to analyze the role of right to information in ensuring good governance in Pakistan. The study objectives were to investigate the experiences of public information officers and civil society actors regarding the right to information contribution to good governance and to analyze the challenges in the implementation of right to information law. For the selection of sampling size, purposive sampling was used and data were collected from 11 ministries public information officers and 3 civil society actors through in depth interviews in Islamabad, Pakistan. Being qualitative study, data were analyzed by using thematic analyses. Jurgen Habermas theory of ‘Public Sphere” was used to throw light on main theme of the study. The findings indicated that right to information is an effective tool in promoting good governance along with all its features like, accountability, transparency, mutual trust between the government and general public, common man facilitation, rule of law and corruption elimination. Study concluded that right to information would be an effective tool in promoting the good governance only when hurdles that prevent it from its true implementation were removed.
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41

Nicolas, N., X. Mariette, F. Tubach, C. Michelet, P. Dellamonica, O. Lortholary та D. Salmon. "COL2-04 Risque d’infections opportunistes (IO) sous traitement par anti TNF α : résultats finaux des 3 ans de surveillance de l’observatoire RATIO". Médecine et Maladies Infectieuses 39 (червень 2009): S2. http://dx.doi.org/10.1016/s0399-077x(09)74269-6.

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42

Wale, Astrid. "Nils Ivar Agøy og Ellen Schrumpf (red.): Telemarks historie 1814–1905, bind 2. Olav Rovde og Ingvar Skobba (red.): Telemarks historie etter 1905, bind 3." Heimen 52, no. 04 (December 17, 2015): 390–94. http://dx.doi.org/10.18261/issn1894-3195-2015-04-09.

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43

Nikooyeh, Bahareh, Zahra Abdollahi, Majid Hajifaraji, Hamid Alavi-Majd, Forouzan Salehi, Amir Hossein Yarparvar, and Tirang R. Neyestani. "Healthy changes in some cardiometabolic risk factors accompany the higher summertime serum 25-hydroxyvitamin D concentrations in Iranian children: National Food and Nutrition Surveillance." Public Health Nutrition 21, no. 11 (March 27, 2018): 2013–21. http://dx.doi.org/10.1017/s1368980018000630.

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AbstractObjectiveTo investigate seasonal variations of vitamin D status at different latitudes and if these changes are accompanied by corresponding variations in certain health parameters in children living in a broad latitudinal range in Iran.DesignLongitudinal study.SubjectsIn total, 530 apparently healthy children aged 5–18 years were randomly selected from six regions of Iran with a latitudinal gradient from 29°N to 37·5°N. All anthropometric and biochemical assessments were performed twice during a year (summer, winter). High BMI (Z-score >1), low HDL cholesterol (<40 mg/dl, males; <50 mg/dl, females) and high TAG (>150 mg/dl) were considered cardiometabolic risk factors.ResultsSerum 25-hydroxyvitamin D (25(OH)D) showed between-season variation, with significantly higher concentrations (mean (sd)) in summer v. winter (43 (29) v. 27 (18) nmol/l; P<0·001). Change of circulating 25(OH)D between summer and winter was negatively correlated with change of BMI (r=−0·16; P<0·001), TAG (r=−0·09; P=0·04) and total cholesterol (r=−0·10; P=0·02) and directly correlated with change of height-for-age Z-score (r=0·09; P=0·04). Multiple stepwise linear regression analysis (β; 95 % CI) showed that winter serum 25(OH)D (−0·3; −0·4, −0·2; P<0·001), gender (boys v. girls: 9·7; 5·2, 14·1; P<0·001) and latitude (>33°N v. <33°N: 4·5; 0·09, 9·0; P=0·04) were predictors of change of serum 25(OH)D between two seasons.ConclusionsSummertime improvement of vitamin D status was accompanied by certain improved cardiometabolic risk factors, notably serum TAG, total cholesterol and BMI, in children.
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44

Ho, T. W. "FP58-FR-04 Clinical profile of the novel oral CGRP receptor antagonist telcagepant for the acute treatment of migraine in phase 3 studies." Journal of the Neurological Sciences 285 (October 2009): S149—S150. http://dx.doi.org/10.1016/s0022-510x(09)70578-7.

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45

Garban, Frederic, Michel Attal, Mauricette Michallet, Cyrille Hulin, Jean H. Bourhis, Ibrahim Yakoub-Agha, Thierry Lamy, et al. "Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma." Blood 107, no. 9 (May 1, 2006): 3474–80. http://dx.doi.org/10.1182/blood-2005-09-3869.

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The Intergroupe Francophone du Myélome (IFM) initiated 2 trials in 1999 to study patients with high-risk (β2-microglobulin level greater than 3 mg/L and chromosome 13 deletion at diagnosis) de novo multiple myeloma. In both protocols, the induction regimen consisted of vincristine, doxorubicin, and dexamethasone (VAD) followed by first autologous stem cell transplantation (ASCT) prepared by melphalan 200 mg/m2. Patients with an HLA-identical sibling donor were subsequently treated with dose-reduced allogeneic stem cell transplantation (IFM99-03 trial), and patients without an HLA-identical sibling donor were randomly assigned to undergo second ASCT prepared by melphalan 220 mg/m2 and 160 mg dexamethasone with or without anti–IL-6 monoclonal antibody (IFM99-04 protocol). Two hundred eighty-four patients—65 in the IFM99-03 trial and 219 in the IFM99-04 trial—were prospectively treated and received at least one course of VAD. On an intent-to-treat basis, overall survival (OS) and event-free survival (EFS) did not differ significantly in the studies (medians 35 and 25 months in the IFM99-03 trial vs 41 and 30 months in the IFM99-04 trial, respectively). With a median follow-up time of 24 months, the EFS of the 166 patients randomly assigned in the tandem ASCT protocol was similar to the EFS of the 46 patients who underwent the entire IFM99-03 program (median, 35 vs 31.7 months), with a trend for a better OS in patients treated with tandem ASCT (median, 47.2 vs 35 months; P = .07). In patients with high-risk de novo MM, the combination of ASCT followed by dose-reduced allogeneic transplantation was not superior to tandem dose–intensified, melphalan-based ASCT.
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46

Assylbekova, S., N. Badryzlova, and L. Kushnikova. "Analysis of the rates of development and growth of Brachymystax lenok Savinovi during artificial reproduction by the industrial method." Rybovodstvo i rybnoe hozjajstvo (Fish Breeding and Fisheries), no. 7 (July 1, 2020): 40–49. http://dx.doi.org/10.33920/sel-09-2007-04.

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The article presents the results of the first research on artificial reproduction in industrial conditions of the endemic, narrow-areal subspecies of Brachymystax lenok Savinovi, which lives in lake Markakol, East Kazakhstan region. The indicators of the heat sum characteristic for each stage of development, the rate of development and growth of the Markakolsky lenok from the moment of pre-breeding to late juveniles are described. To develop technological approaches for artificial fish reproduction, one of the most important points is to determine the optimal conditions for each stage and assess the risks (loss of fish products). At the stage of insemination and transportation of eggs to the place of incubation, the loss was 50 %. The largest losses of fish products were registered during the incubation stage. The most painlessly passed the period of holding and lifting on the float, where the loss was only 3 %. When growing pre-larvae and larvae in the pool, the daily waste did not exceed 1 %. Small-sized animals that were unable to adapt to artificial feeds fell into the waste. Losses during this period amounted to 15 % of the previous stage. In General, the yield of juveniles from the moment of fertilization to the end of the experiment was 16 %. The crucial factor in the development and growth of Lenok Markakolosky is the temperature regime. For the period of embryonic development, the most favorable water temperature is 7–8 °C. From the moment of hatching, the water temperature must be increased to 10–12 °C, and the optimal temperature for the cage growing of fingerlings varies from 12 to 14 °C.
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47

Silkina, N. I., D. V. Mikryakov, and V. R. Mikryakov. "Relationship of the average monthly temperature of February and some immunological indicators of the bream in the Rybinsk reservoir in different years." Rybovodstvo i rybnoe hozjajstvo (Fish Breeding and Fisheries), no. 10 (October 1, 2020): 38–45. http://dx.doi.org/10.33920/sel-09-2010-04.

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A study of changes in some immunological parameters of fish blood serum depending on the average monthly air temperature was carried out. The studies were carried out on bream aged 3+, with an average weight of 375 ± 30 g and a length of 290 ± 20 cm, caught in the Volga reach of the Rybinsk reservoir. The fish were caught using fixed nets in February for several years and the average monthly air temperature was recorded. The studied fish were sampled from the tail vein. Blood was collected in a dry sterile test tube and kept at room temperature. After blood coagulation and retraction of the clot, the serum was taken with a syringe with a fine needle and transferred to another tube. To assess the state of natural immunity in the blood serum, the level of bactericidal activity and nonspecific immune complexes was analyzed. Based on the data obtained, the number of immunodeficient individuals was determined. Variations of the studied parameters in years different in average monthly air temperature were established. The greatest differences between the indicators were revealed in the years with the highest (2003) and lowest (2006) mean monthly temperatures. The minimum indicators of bactericidal activity were recorded in 2003, and the maximum — in 2006. The highest content of immune complexes and immunodeficient individuals was established in 2003, and the lowest in 2006. The study showed the relationship between an increase in the average monthly air temperature and a decrease in functional activity nonspecific humoral immunity. Based on the data obtained, it was concluded that the temperature factor influences the mechanisms of innate immunity of fish.
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48

Allen, D. A., E. R. Wilson, J. A. Lineberger, T. Lehenbauer, and E. M. Moeller. "Long-term outcomes of thigh circumference, stifle range-of-motion, and lameness after unilateral tibial plateau levelling osteotomy." Veterinary and Comparative Orthopaedics and Traumatology 23, no. 01 (2010): 37–42. http://dx.doi.org/10.3415/vcot-09-04-0043.

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SummaryOur study evaluated thigh circumference (TC), stifle range of motion (ROM), and lameness in dogs one to five years after unilateral tibial plateau levelling osteotomy (TPLO). We hypothesised that TC, stifle ROM, and lameness would not be different to the unoperated limb (control), one to five years after surgery. Patients that were one to five years post-TPLO were reviewed and were included if they had a unilateral TPLO, and no additional clinical evidence of orthopaedic disease. Standing mid-thigh TC measurements and stifle extension and flexion angles were made in triplicate. Clinical lameness was graded blindly. Data were evaluated statistically using paired t-tests for TC and stifle flexion and extension. Significance was set at p <0.05. Twenty-nine dogs met the inclusion criteria. Mean results for the surgery limbs and control limbs were 39.5 ± 5.5 cm and 40.1 ± 5.6 cm for TC, 36.6 ± 6.8° and 28.6 ± 4.3° for stifle flexion, and 155.2 ± 6.6° and 159.8 ± 4.9° for stifle extension, respectively. The mean TC for the operated limb was 98.5% of the control limb. A significant difference was found between the operated and the control limbs for all measurements. Time after surgery had no apparent affect on outcome. Four of 29 dogs (14%) exhibited some lameness in the TLPO limb during evaluation (one dog was 1 to 2 years postoperative and three dogs were 2 to 3 years postoperative). These results indicate that TC and stifle ROM in the TLPO limb do not return to control-limb measurements one to five years after a TPLO surgery. The clinical significance is unknown as TC returned to 98.5% of control, and the source of lameness in the lame dogs was not identified.
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49

Rozumnaya, Lyubov Anatolyevna, Galina Iozepovna Pronina, Alexander Borisovich Petrushin, and Elena Ivanovna Shishanova. "Theoretical and practical aspects of domestication of common catfish (Silurus glanis, L.)." Rybovodstvo i rybnoe hozjajstvo (Fish Breeding and Fisheries), no. 1 (January 1, 2021): 42–56. http://dx.doi.org/10.33920/sel-09-2101-04.

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The article discusses some aspects of the domestication of common catfish (Silurus glanis) in the conditions of cyprinid fish farms. Under the pressure of selection and directed cultivation in pond conditions of carp fish farms, changes in ethological, morphological, and physiological indicators are observed. The variability of the majority of morphological indicators and development indices (8–14%) indicates a high degree of consolidation of the resulting breeding offspring and indicates the completion of the first stage of domestication in the conditions of fish-breeding carp farms. Physiological and biochemical assessment of different age categories of catfish showed low variability of physiological indicators. it Can be assumed that the decrease in the coefficient of variability is a consequence of domestication. Studies of the immunological status have shown its optimal level, which allows us to accept the obtained indicators as indicative standards for evaluating brood flocks and their offspring. There was a significant increase in the body weight of commercial three-year-olds of the 4th breeding generation, compared with the first generation. It is established that the reproduction of catfish planted in carp summer-fallow ponds is more successful than in natural reservoirs, since ponds of this category are often small, well-warmed, which contributes to the rapid maturation of producers and the development of caviar. When growing in pond conditions for 2–3 generations, changes in behavioral reactions were noted — there was a decrease in aggressiveness and the development of conditioned reflexes to the specified food objects. The level of food availability affects the metabolism and maturation period, so along with the use of the natural feed base of the pond, it is recommended to use additional feeding and directed formation of the natural feed base.
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50

Cattoen, C., K. Blanckaert, P. Cabaret, B. Grandbastien, I. Joly, T. Levent, and M. Roussel Delvallez. "V-04 Données épidémiologiques relatives à Escherichia coli sécréteur de bêta-lactamase à spectre étendu (BLSE) dans les établissements de soins du Nord – Pas de Calais (NPDC)." Médecine et Maladies Infectieuses 39 (June 2009): S21—S22. http://dx.doi.org/10.1016/s0399-077x(09)74320-3.

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