Статті в журналах: "62-83:621.313.2"

1

BASAK, Ajoy, and Claude LAZURE. "Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes." Biochemical Journal 373, no. 1 (July 1, 2003): 231–39. http://dx.doi.org/10.1042/bj20030120.

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Proprotein convertases (PCs) are Ca2+-dependent serine proteases of the subtilisin/kexin family which are known specifically to cleave propeptide and proprotein substrates at the C-terminal of R-X-(K/R)-R↓ to generate the relevant biologically active peptides. PCs are initially synthesized as enzymically inactive proenzyme forms where the prosegments play an important inhibitory role to the respective enzymes. Here we investigated whether synthetic peptides derived from the pro-region could also represent specific and potent inhibitors. Based upon sequence alignment, secondary structure analysis and hydrophilicity plot, a number of peptides ranging from 8 to 33 residues were selected. These included segments encompassing residues 55–62, 50–62, 39–62, 50–83, 55–83, 64–83 and 74–83 in the pro-mouse PC1/3 sequence and residues 54–62, 48–62 and 39–62 of the pro-human furin sequence. All peptides were prepared by solid-phase FastMoc chemistry, purified by reversed-phase HPLC and characterized by MS and amino acid analysis. These peptides were tested in vitro for inhibitory activity towards recombinant mouse PC1/3 and human furin. Progress-curve and end-time kinetic analysis demonstrated that a number of these peptides, particularly those containing both the primary and the secondary processing sites, displayed strong inhibition of both enzymes with inhibition constants (Ki) in the high nanomolar range. Unlike the whole propeptide, these small synthetic peptide inhibitors exhibited either true competitive or mixed competitive inhibition, depending on the sequence. Our data revealed further the critical role of the last two basic amino acid residues (e.g. Lys82-Arg83 for the mouse PC1/3 sequence) of the prodomain in imparting a strong anti-convertase activity. The study also establishes the inhibitory potential of certain regions contained within the prosegment of the two convertases.

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2

Murillo, José Manuel. "Dos publicaciones sobre la lengua rama." Wani 62 (October 31, 2012): 82–83. http://dx.doi.org/10.5377/wani.v62i0.861.

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3

Bourque, S. N., J. R. Valero, M. C. Lavoie, and R. C. Levesque. "Comparative Analysis of the 16S to 23S Ribosomal Intergenic Spacer Sequences of Bacillus thuringiensis Strains and Subspecies and of Closely Related Species." Applied and Environmental Microbiology 61, no. 7 (July 1995): 2811. http://dx.doi.org/10.1128/aem.61.7.2811-2811b.1995.

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Volume 61, no. 4, p. 1624, column 2, lines 38-41: The sentence should read "For example, at position 21, the G nucleotide (Fig. 1) was present in all the ISR B. thuringiensis subspecies except for B. thuringiensis subsp. tenebrionis (Te4), which contained an A." Page 1624, column 2, line 45: "Position 62" should read "position 11." Page 1624, column 2, line 47: "Position 90" should read "position 39." Page 1624, column 2, line 49: "Position 83" should read "position 32." Page 1625, column 1, line 3: "Position 83" should read "position 32." Page 1626, column 1, line 1: "Positions 62, 90, and 165, and one deletion at position 83" should read "positions 11, 39, and 114, and one deletion at position 32." [This corrects the article on p. 1623 in vol. 61.].

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4

Kolozova, Katerina, and Rodna Ruskovska. "Structure, Matter and Pure Form: Marx, Laruelle and Irigaray." Identities: Journal for Politics, Gender and Culture 14, no. 1-2 (June 1, 2017): 62–83. http://dx.doi.org/10.51151/identities.v14i1-2.319.

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Author(s): Katerina Kolozova | Катерина Колозова Title (English): Structure, Matter and Pure Form: Marx, Laruelle and Irigaray Title (Macedonian): Структура, материја и чиста форма: Маркс, Ларуел и Иригаре Translated by (English to Macedonian): Rodna Ruskovska | Родна Русковска Transcribed by: Stanimir Panayotov Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 14, No. 1 (Winter 2017) Publisher: Institute of Social Sciences and Humanities – Skopje Page Range: 62-83 Page Count: 21 Citation (English): Katerina Kolozova, “Structure, Matter and Pure Form: Marx, Laruelle and Irigaray,” Identities: Journal for Politics, Gender and Culture, Vol. 14, No. 1 (Winter 2017): 62-81. Citation (Macedonian): Катерина Колозова, „Структура, материја и чиста форма: Маркс, Ларуел и Иригаре“, превод од англиски Родна Русковска, Идентитети: списание за политика, род и култура, т. 14, бр. 1 (зима 2017): 62-83.

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5

Kubiś, Adam. "Emaus. Tajemnice dnia ósmego." Verbum Vitae 28 (December 1, 2015): 461–73. http://dx.doi.org/10.31743/vv.1642.

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6

Pruß, Axel, Bernard Schroeter, and Matthias Löwel. "Auswirkungen der Fälschungsrichtlinie 2011/62/EU und der Delegierten Verordnung (EU) Nr. 2016/161 auf Gewebezubereitungen und Blutprodukte." Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie 9, no. 03 (August 2019): 173–78. http://dx.doi.org/10.1055/a-0832-7023.

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ZusammenfassungAb dem 09.02.2019 müssen auch in Deutschland die von der Richtlinie 2011/62/EU in Verbindung mit der Delegierten Verordnung (EU) 2016/161 zur Ergänzung der Richtlinie 2001/83/EG erfassten Humanarzneimittel mit zusätzlichen Sicherheitsmerkmalen und einer Vorrichtung zum Erkennen einer möglichen Manipulation versehen werden. Nach aktueller Einschätzung des Paul-Ehrlich-Instituts sind die primär davon betroffenen Gewebezubereitungen mit einer Zulassung gemäß §§ 21, 25 Arzneimittelgesetz (AMG) nicht als unter die Richtlinie 2001/83/EG fallend einzustufen, da sie nicht mit einem industriellen Verfahren hergestellt werden. Die Fälschungsrichtlinie 2011/62/EU und die Delegierte Verordnung (EU) Nr. 2016/161 finden daher keine Anwendung. Außer den in der Anlage I der Delegierten Verordnung (EU) 2016/161 genannten Ausnahmen sind darüber hinaus auch Blutkomponenten (Vollblut, Plasma und Blutzellen menschlichen Ursprungs) gemäß Art. 3 Nr. 6 der Richtlinie 2001/83/EG vom Anwendungsbereich der Richtlinie ausgenommen. Insofern besteht lediglich für Plasmen, bei deren Herstellung ein industrielles Verfahren zur Anwendung kommt, sowie die aus diesen Plasmen resultierenden Plasmaderivate eine Verpflichtung, den Vorgaben von Fälschungsrichtlinie und Delegierter Verordnung nachzukommen.

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7

Wallander, H., S. Larsson, T. Bjönness, and G. Hansson. "Patient-reported outcome at 62 to 67 years of age in 83 patients treated for congenital clubfoot." Journal of Bone and Joint Surgery. British volume 91-B, no. 10 (October 2009): 1316–21. http://dx.doi.org/10.1302/0301-620x.91b10.22796.

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8

Podzielny, Janusz. "Jan Kochel, Duchowa pedagogia miłości, wyd. Agape, Poznań 2018, ss. 294, ISBN 978-83-64774-62-1." Studia Teologiczno-Historyczne Śląska Opolskiego 38, no. 1 (October 31, 2018): 283–85. http://dx.doi.org/10.25167/rtso/38(2018)1/283-285.

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9

Rowe, Penny M., Larry M. Miloshevich, David D. Turner, and Von P. Walden. "Dry Bias in Vaisala RS90 Radiosonde Humidity Profiles over Antarctica." Journal of Atmospheric and Oceanic Technology 25, no. 9 (September 1, 2008): 1529–41. http://dx.doi.org/10.1175/2008jtecha1009.1.

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Abstract Middle to upper tropospheric humidity plays a large role in determining terrestrial outgoing longwave radiation. Much work has gone into improving the accuracy of humidity measurements made by radiosondes. Some radiosonde humidity sensors experience a dry bias caused by solar heating. During the austral summers of 2002/03 and 2003/04 at Dome C, Antarctica, Vaisala RS90 radiosondes were launched in clear skies at solar zenith angles (SZAs) near 83° and 62°. As part of this field experiment, the Polar Atmospheric Emitted Radiance Interferometer (PAERI) measured downwelling spectral infrared radiance. The radiosonde humidity profiles are used in the simulation of the downwelling radiances. The radiosonde dry bias is then determined by scaling the humidity profile with a height-independent factor to obtain the best agreement between the measured and simulated radiances in microwindows between strong water vapor lines from 530 to 560 cm−1 and near line centers from 1100 to 1300 cm−1. The dry biases, as relative errors in relative humidity, are 8% ± 5% (microwindows; 1σ) and 9% ± 3% (line centers) for SZAs near 83°; they are 20% ± 6% and 24% ± 5% for SZAs near 62°. Assuming solar heating is minimal at SZAs near 83°, the authors remove errors that are unrelated to solar heating and find the solar-radiation dry bias of 9 RS90 radiosondes at SZAs near 62° to be 12% ± 6% (microwindows) and 15% ± 5% (line centers). Systematic errors in the correction are estimated to be 3% and 2% for microwindows and line centers, respectively. These corrections apply to atmospheric pressures between 650 and 200 mb.

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10

STUDAHL, A., and Y. ANDERSSON. "Risk factors for indigenous campylobacter infection: a Swedish case-control study." Epidemiology and Infection 125, no. 2 (October 2000): 269–75. http://dx.doi.org/10.1017/s0950268899004562.

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A case-control study was conducted in western Sweden (Älvsborg County). The aim of the study was to identify any special food items or behaviours associated with an increased risk of contracting campylobacter infection. A total of 101 cases and 198 controls were matched for age, sex and district of residence. The following risk factors or risk behaviours were associated with campylobacter infection: drinking unpasteurized milk (OR 3·56, 95% CI 1·46–8·94), eating chicken (OR 2·29, 95% CI 1·29–4·23), or eating pork with bones (chops OR 2·02, 95% CI 1·17–3·64; loin of pork OR 1·83, 95% CI 1·07–3·12), barbecuing (OR 1·98, 95% CI 1·10–4·34), and living or working on a farm (farm OR 3·06, 95% CI 1·58–6·62, hen/chicken-breeder OR 3·32, 95% CI 1·56–6·78), daily contact with chickens or hens (OR 11·83, 95% CI 3·41–62·03).

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11

Dalal, Anuj K., Jeffrey Schnipper, Anthony Massaro, John Hanna, Eli Mlaver, Kelly McNally, Diana Stade, Constance Morrison, and David W. Bates. "A web-based and mobile patient-centered ‘‘microblog’’ messaging platform to improve care team communication in acute care." Journal of the American Medical Informatics Association 24, e1 (August 18, 2016): e178-e184. http://dx.doi.org/10.1093/jamia/ocw110.

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Communication in acute care settings is fragmented and occurs asynchronously via a variety of electronic modalities. Providers are often not on the same page with regard to the plan of care. We designed and developed a secure, patient-centered “microblog” messaging platform that identifies care team members by synchronizing with the electronic health record, and directs providers to a single forum where they can communicate about the plan of care. The system was used for 35% of patients admitted to a medical intensive care unit over a 6-month period. Major themes in messages included care coordination (49%), clinical summarization (29%), and care team collaboration (27%). Message transparency and persistence were seen as useful features by 83% and 62% of respondents, respectively. Availability of alternative messaging tools and variable use by non-unit providers were seen as main barriers to adoption by 83% and 62% of respondents, respectively. This approach has much potential to improve communication across settings once barriers are addressed.

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12

Xue, Lin, Feng Luo, Yun-xia Che, and Ji-min Zheng. "A noninterpenetrating 3D coordination network with rare (4,6)-connected (4·53·62)2(42·56·64·83) topology." Journal of Molecular Structure 832, no. 1-3 (April 2007): 132–37. http://dx.doi.org/10.1016/j.molstruc.2006.08.025.

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13

Hambling, P. M. "QARNNS Update." Journal of The Royal Naval Medical Service 83, no. 2 (June 1997): 62–63. http://dx.doi.org/10.1136/jrnms-83-62.

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14

Tewari, Nitesh, Vijay Prakash Mathur, Rigzin Tamchos, and Morankar Rahul. "Oral manifestations of lamellar ichthyosis in association with rickets." BMJ Case Reports 13, no. 7 (July 2020): e235008. http://dx.doi.org/10.1136/bcr-2020-235008.

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Lamellar ichthyosis (LI) is a rare genetic condition that affects the skin, with an incidence of less than 1:300 000 in different parts of the world. This report describes a case of a 5-year-old girl with LI and rickets presenting with premature loss of 51, 52, 61, 62 and 71, grade II mobility in 72, 73, 81, 82 and 83 along with loss of supporting bone with 53, 63, 72, 73, 82 and 83. This is the first report describing oral manifestations of this combination of LI and rickets.

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15

Battle, James. "Relationship between Self-Esteem and Depression among Children." Psychological Reports 60, no. 3_part_2 (June 1987): 1187–90. http://dx.doi.org/10.1177/0033294187060003-237.1.

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62 boys and girls enrolled in Grades 4 through 9 participated in the study. The correlations were significant and ranged from .44 to –- .83 between scores on all facets of a modified version of Beck's Depression Inventory and the Culture-free Self-esteem Inventory for Children, Form A.

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16

Du, Miao, Zhi-Hui Zhang, Xiu-Guang Wang, and Xiao-Jun Zhao. "A 3-D (3,5)-connected CdII coordination framework with unique twofold interpenetrating (4·62)(4·66·83) network topology." Inorganica Chimica Acta 362, no. 4 (March 2009): 1358–60. http://dx.doi.org/10.1016/j.ica.2008.05.015.

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17

Sommer, Michael, Thomas Hiller, Jörg Breitbart, Nico Schneider, Tobias Teismann, Antje Freytag, and Jochen Gensichen. "Standardtherapie für Panikstörung mit/ohne Agoraphobie in der Hausarztpraxis." Psychiatrische Praxis 45, no. 03 (May 12, 2017): 160–63. http://dx.doi.org/10.1055/s-0043-105058.

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Zusammenfassung Ziel Beschreibung der hausärztlichen Standardtherapie (Therapy As Usual, TAU) bei Panikstörung mit/ohne Agoraphobie (PDA). Methoden Schriftliche Befragung von 38 Hausärzten, die in einer Interventionsstudie 189 Patienten mit PDA behandelten. Ergebnisse TAU beinhaltete eine Mischung aus psychosozialen (Besprechung psychosozialer Probleme, 83 %) und pharmakologischen (SSRI, 62 %) Interventionen. Schlussfolgerung TAU erscheint weitgehend leitliniengerecht. Die Generalisierbarkeit der Ergebnisse ist studienbedingt eventuell eingeschränkt.

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Hartley, Bennett W., and Craig A. Sinkinson. "Assessment of the Maya’s Beliefs and Preferences on Bonesetters and Bone Fracture Treatment in the Guatemalan Highlands: A Household Survey." Global Journal of Health Science 13, no. 3 (February 8, 2021): 89. http://dx.doi.org/10.5539/gjhs.v13n3p89.

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BACKGROUND: In the Lake Atitlán region of Guatemala, traditional bonesetters (hueseros) commonly treat bone fractures. The indigenous Kaqchikel population has access to biomedical care, but traditional medicine remains the preferred treatment modality for bone fracture. METHODS: Households in four villages were surveyed to assess experiences with bone fracture treatment. Of 108 households sampled, 83 met inclusion criteria and completed the survey. Responses were analyzed to assess for group demographics, bone fracture prevalence, and treatment history. Independence testing assessed for subgroup differences. RESULTS: Mean age: 40 years old. For fracture treatment, 37% (31/83) consulted with a physician/nurse whereas 75% (62/83) consulted with a bonesetter. 19% (16/83) consulted with both. Cast immobilization was utilized by only 16% (13/83) of participants. The services provided by bonesetters included massage, temazcal (sweat lodge), herbal poultice, prayer, and recommended rest. When comparing participants that used a cast (n=13) and those that used a bonesetter exclusively (n=46), the bonesetter group had lower rates of continued pain and movement limitation, higher satisfaction with treatment, and higher interest in seeking the same treatment in the future, though these findings were not statistically significant. Regarding future care, 66% (55/83) would consider consulting a doctor whereas 83% (69/83) would seek services from a bonesetter. 53% (44/83) would utilize both.  If recommended, 46% (38/83) would consider using a cast. Only 22% (18/83) of participants reported previous musculoskeletal imaging. CONCLUSION: These results suggest a high preference of bonesetters for bone injury treatment, reduced acceptance of biomedical care, and limited acceptance of cast immobilization.

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Seitz, Alexander M. "No Prohibition of Dissemination of Information on Prescription-Only Medicinal Products on a Manufacturer's Website." European Journal of Risk Regulation 2, no. 3 (September 2011): 447–49. http://dx.doi.org/10.1017/s1867299x00001495.

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Article 88 (1) (a) of Directive 2001/83/EC must be interpreted as meaning that it does not prohibit the dissemination on a website, by a pharmaceutical undertaking, of information relating to medicinal products available on medical prescription only, where that information is accessible on the website only to someone who seeks to obtain it and that dissemination consists solely in the faithful reproduction of the packaging of the medicinal product, in accordance with Article 62 of Directive 2001/83, and in the literal and complete reproduction of the package leaflet or the summary of the product's characteristics, which have been approved by the authorities with competence in relation to medicinal products (official headnote).

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20

Puspita, Mita, Slameto Slameto, and Eunice Widyanti Setyaningtyas. "PENINGKATKAN HASIL BELAJAR MATEMATIKA SISWA KELAS 4 SD MELALUI MODEL PEMBELAJARAN PROBLEM BASED LEARNING." Justek : Jurnal Sains dan Teknologi 1, no. 1 (April 30, 2018): 120. http://dx.doi.org/10.31764/justek.v1i1.416.

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Abstrak: Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang bertujuan untuk meningkatkan hasil belajar matematika dengan menggunakan model pembelajaran Problem Based Learning. Pada kondisi awal menunjukkan nilai rata-rata secara klasikal yang diperoleh yaitu 62. Setelah diberikan tindakan dengan model pembelajaran Problem Based Learning siklus 1 menunjukkan nilai rata-rata yang diperoleh 77,37. Pada siklus 2 rata-rata ketuntasan hasil belajar siswa meningkat 83 Hasil ini menunjukkan bahwa adanya peningkatan hasil belajar siswa dengan menggunakan model pembelajaran Problem Based Learning , sehingga dapat disimpulkan bahwa model pembelajaran Problem Based Learning dapat meningkatkan hasil belajar matematika siswa. Abstract: This research is classroom action research to improve the learning results of mathematics by using the model of Problem Based Learning. On initial conditions indicate the average score in classical obtained, that is 62. After the given action by the model Problem Based Learning in the cycle 1 shows average score obtained was 77,37. In cycle 2, the average of the result of student learning increased to reach 83. These results suggest that there was an increase in student learning out comes by using the model Problem Based Learning, so it can be concluded that the model of Problem Based Learning can improve the result of learning mathematics on 4 grades student.

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Morris, Claudia R., Jennifer Gardner, Andrew Wen, Shanda Robertson, Ward Hagar, and Elliott Vichinsky. "Abnormal Pulmonary Function in Adults and Children with Sickle Cell Disease." Blood 106, no. 11 (November 16, 2005): 2319. http://dx.doi.org/10.1182/blood.v106.11.2319.2319.

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Abstract Introduction: Chronic lung disease is a fatal complication in sickle cell disease (SCD) often undiagnosed until late stages. Early detection and treatment of risk factors may improve survival. Since asthma, pulmonary hypertension (PHT), and acute chest syndrome (ACS) are potential risk factors, in 1998, we began screening patients with history of ACS or wheezing with pulmonary function tests (PFT) and echocardiogram (echo). Methods: A chart review was completed on the 362 adults and children evaluating history of asthma, lung function (PFT) and PHT (echo, tricuspid regurgitant jet velocity ≥ 2.5). Results: PFT Findings All Ages Adults Children PHT (All Ages) Study performed 34% (124/362) 41% (95/232) 22% (29/130) Echo: 90% (111/124) Abnormal 85% (106/124) 87% (83/95) 79% (23/29) 51% (54/106) Obstructive (OBS) only 31% (33/106) 31% (26/83) 30% (7/23) 42% (14/33) Restrictive (REST) only 30% (32/106) 28% (23/83) 39%(9/23) 38% (12/32) Both OBS + REST pattern 27% (29/106) 29% (24/83) 22% (5/23) 69% (20/29) “Abnormal,” not specified 11% (12/106) 12% (10/83) 9% (2/23) 67% (8/12) DLCO < 65% predicted 48% (45/94) 53% (42/80) 21% (3/14) 54% (26/48) Diagnosis & Treatment Clinical asthma diagnosis 13% (47/362) 14% (33/232) 11% (14/130) 43% (20/47) Receiving asthma treatment 51% (24/47) 45% (15/33) 64% (9/14) 50% (12/24) Bronchodilator only 23% (11/47) 24% (8/33) 21% (3/14) 45% (5/11) Inhaled steroid 23% (11/47) 18% (6/33) 36% (5/14) 55% (6/11) Singulair 4% (2/47) 3% (1/33) 7% (1/14) 50% (1/2) PFT suggests asthma 50% (62/124) 53% (50/95) 41% (12/29) 53% (33/62) +PFT, + asthma treatment 16% (10/62) 14% (7/50) 25% (3/12) 80% (8/10) One hundred twenty-four patients underwent PFTs, of which 111 (85%) were abnormal. Obstructive and/or restrictive disease with abnormal diffusion capacity were widespread. Of patients with an obstructive pattern, only 16% were receiving any asthma treatment. Forty-seven patients (33 adults and 14 children) were diagnosed with asthma. However, only half were receiving any treatment: 23% bronchodilators, and 23% inhaled steroids. Echo was performed on 90% of patients with PFT data. Half of all patients with abnormal PFTs, and 69% of those with obstructive/restrictive patterns, had PHT. Conclusion: While a more severe population may have been tested, this data suggests abnormal lung function is prevalent in SCD and is associated with PHT. Recent data suggests abnormal NO metabolism may link asthma and PHT in SCD. In conclusion, our data suggests patient morbidity will be decreased by regular screening with PFT and echo followed by early treatment for asthma and PHT.

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Hahn, Theresa, Philip L. McCarthy, Anna Hassebroek, John P. Klein, J. Douglas Rizzo, Susan Parsons, Steven Joffe, and Navneet S. Majhail. "Significant Improvement In Day 100 and 1-Year Overall Survival In Patients Who Underwent Myeloablative Allogeneic Hematopoietic Cell Transplant In the US or Canada Between 1994 and 2005." Blood 116, no. 21 (November 19, 2010): 3509. http://dx.doi.org/10.1182/blood.v116.21.3509.3509.

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Abstract Abstract 3509 Allogeneic hematopoietic cell transplantation (alloHCT) has become standard therapy for hematologic disorders and malignancies. We assessed whether overall survival (OS) at 100 days, which represents early transplant-related mortality (TRM), and at one year, which represents disease-related mortality and later TRM, had changed over time. The study population was derived from patients undergoing 38,060 first alloHCTs between 1994–2005 in US and Canadian centers and reported to the CIBMTR. Donor lymphocyte infusions were excluded. Statistical significance was measured using Ptrend over 6 time cohorts to test whether the OS estimates were stable (slope = 0), increasing (slope>0) or decreasing (slope<0) over time. The Day 100 and 1 year OS estimates are shown in the Table. Disease and disease status subgroups were defined a priori, and the OS estimates are not adjusted for any covariates such as age, Karnofsky status, etc. Marked improvements in 100-day survival were seen for all disease and disease status groups examined. Day 100 mortality rates in HLA-matched sibling alloHCT recipients during the most recent period (2004-5) were as low as 2% for CML treated in CP1, 6–8% for AML in CR1 and ALL in CR2, and a modest 12% for MDS. Even in alloHCT recipients with unrelated donors treated in 2004-5, the Day 100 mortality rates ranged from 9–22%, a significant decrease from historical mortality rates of 29–37%. Significant improvements in 1-year OS were noted for all groups undergoing unrelated-donor alloHCT; however, among those undergoing HLA-matched sibling alloHCT, significant improvements in 1-year OS were only seen in patients with CML in CP1 or MDS. OS has improved for many patients undergoing myeloablative alloHCT, which likely reflects improvement in supportive care and better patient/donor selection. Day 100 OS has significantly improved in all patients who received a myeloablative HLA-matched related or unrelated donor alloHCT. Significant improvement in 1-year OS was also experienced by most patients. Table: Overall survival (95% CI) estimates over time HLA-Matched Sibling Myeloablative Allogeneic HCT 1994-5 1996-7 1998-9 2000-1 2002-3 2004-5 Ptrend AML in CR1 N 370 370 383 376 384 440 <0.001 @100 days 85 (81–88) 87 (84–90) 90 (86–93) 88 (84–91) 92 (89–94) 94 (91–96) 0.1662 @1 year 69 (65–74) 70 (66–75) 72 (67–76) 67 (62–72) 74 (69–78) 75 (71–80) ALL in CR2+ N 179 186 149 159 156 163 0.0018 @100 days 77 (70–83) 82 (76–87) 88 (82–93) 85 (79–90) 85 (79–90) 92 (87–96) 0.2937 @1 year 62 (55–69) 63 (56–70) 69 (61–77) 59 (51–67) 64 (56–71) 70 (62–77) CML in CP1 N 483 540 492 317 155 125 <0.001 @100 days 84 (81–87) 88 (85–90) 89 (87–92) 91 (87–94) 99 (96–100) 98 (94–100) <0.001 @1 year 71 (66–75) 72 (68–76) 80 (76–83) 82 (77–86) 89 (83–93) 92 (86–96) MDS N 225 290 273 235 239 227 <0.001 @100 days 71 (65–77) 75 (70–80) 76 (71–81) 82 (77–87) 85 (80–89) 88 (84–92) 0.0488 @1 year 54 (48–61) 51 (45–57) 57 (51–63) 58 (51–65) 61 (55–68) 64 (58–71) Unrelated Donor Myeloablative Allogeneic HCT 1994-5 1996-7 1998-9 2000-1 2002-3 2004-5 Ptrend AML in CR1 N 52 75 88 135 182 336 <0.001 @100 days 63 (50–76) 64 (53–74) 69 (59–78) 75 (68–82) 82 (76–87) 86 (82–90) 0.0427 @1 year 48 (35–62) 35 (25–47) 48 (37–59) 51 (42–60) 54 (46–61) 56 (50–62) ALL in CR2+ N 129 151 132 116 164 197 <0.001 @100 days 66 (58–74) 70 (62–77) 71 (62–78) 75 (67–82) 78 (71–84) 91 (87–95) <0.001 @1 year 43 (34–51) 45 (37–53) 49 (40–58) 40 (31–50) 54 (46–62) 67 (60–74) CML in CP1 N 211 250 292 152 87 118 0.0006 @100 days 71 (65–77) 70 (64–75) 74 (69–79) 75 (68–81) 80 (71–88) 87 (81–93) 0.0057 @1 year 51 (44–57) 54 (48–61) 59 (53–64) 60 (52–68) 65 (54–75) 71 (62–80) MDS N 104 138 135 140 161 234 <0.001 @100 days 64 (54–73) 62 (54–70) 59 (51–67) 67 (59–75) 74 (67–81) 78 (72–83) <0.001 @1 year 41 (31–50) 44 (35–52) 35 (27–43) 45 (37–54) 52 (44–60) 57 (50–63) Disclosures: No relevant conflicts of interest to declare.

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23

Burnett, Stephanie, Paul Thomas, and Marc van Iersel. "Postgermination Drenches with PEG-8000 Reduce Growth of Salvia and Marigolds." HortScience 40, no. 3 (June 2005): 675–79. http://dx.doi.org/10.21273/hortsci.40.3.675.

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We previously found that incorporation of PEG-8000 into the growing medium delayed germination and resulted in shorter seedlings. However, in that study, we were unable to determine whether the reduced height was merely the effect of delayed germination or of reduced elongation after germination. To answer this question, we studied whether postgermination drenches with PEG-8000 can reduce seedling height. Annual salvia (Salvia splendens F. Sellow. ex Roem. & Shult. `Bonfire') and French marigold (Tagetes patula L. `Boy Orange') seedlings were treated with drenches of PEG-8000: 0, 15, 20, 30, 42, 50, 62, 72, or 83 g·L–1. At least 20% of seedlings treated with 62 to 83 g·L–1 of PEG-8000 were dead 14 d after treatment. Salvia and marigolds treated with the remaining PEG-8000 concentrations were up to 34% and 14% shorter than untreated seedlings, respectively. Leaf water (Ψw) and turgor potential (Ψp) also decreased for salvia which were grown with greater concentrations of PEG-8000, one probable cause of the observed reduction in elongation. Since the PEG-8000 in this study was applied after germination, it is clear that PEG-8000 does not reduce elongation merely by delaying germination, but also by reducing the elongation rate. Thus, postgermination drenches with PEG-8000 can be used to produce shorter seedlings.

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24

Siregar, Iskandar, Riki Ramdhani, Evayusvita Rustam, and Dede Sudrajat. "The Effect of Invigoration Using Polyethylene Glycol And Ultra Fine Bubble on Improving of Sengon Seeds (Falcataria Moluccana Miq.) Quality After Two Years Storage." Jurnal Wasian 8, no. 2 (December 30, 2021): 133–43. http://dx.doi.org/10.20886/jwas.v8i2.5997.

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Utilization of seeds storage results in decreased plant productivity. The increase can be used by treating seeds before planting through the technique of invigoration. This purpose of the study is to assess the effectiveness of invigoration methods using polyethylene glycol (PEG 6000) and ultrafine bubbles (UFB) to improve viability and vigor of sengon seeds (Falcataria moluccana). Seed agieng using 96 % ethanol was carried out to obtain the diversity of seedlot viability as the materials for testing the effectiveness of invigoration treatments. A complete random design was used to test the effectiveness of 5 invigoration treatments, i.e., seed without invigoration treatment, soaking in PEG 6000 -0.8 Mpa, soaking in PEG 6000 -1.2 Mpa, soaking in UFB water injected by environmental air, and soaking in UFB water injected by oxygen 99 %, with soaking time is 24 hours for each treatment. Seed agieng resulted three classes of seed viability, i.e. 62 % (initial seed), 83 % (seed agieng for 30 minutes) and 57 % (seed agieng for 60 minutes). In the condition of seed germination before treatment (DBA) 57 % and DBA 62%, invigoration treatments were significantly affected on seed germination capacity, but not significantly different in DBA 83 %. The soaking treatment of UFB injected by oxigen 99 % was able to improve the germination parameters (germination capacity, germination rate, and vigor index) on the sengon seeds with DBA 57 %. For seeds with DBA 62 %, the soaking treatment in UFB injected by environmental air was provided the best germination capacity, T50, and vigor index. The treatment of UFB injected by oxygen 99 % was more effective to improve the seed with very low viability and vigor (DBA 57 %). In general, improving of seed viability and vigor is more effective by using UFB than PEG 6000.

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25

Khattak, Mohammad Fawad. "Challenges in implementing the 2015 BASHH guidelines for the appropriate use of post-exposure prophylaxis for HIV following sexual exposure." F1000Research 5 (June 9, 2016): 1313. http://dx.doi.org/10.12688/f1000research.8952.1.

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The use of post exposure prophylaxis for human immunodeficiency virus (HIV) following sexual exposure (PEPSE) was retrospectively audited in an inner city genitourinary clinic against the 2015 national guidelines by the British Association for Sexual Health and HIV (BASHH). One-hundred out of a total of 101 patients (99%) had a baseline HIV test done. 82.1% (n=83) of patients were given PEPSE prescriptions fitting within recommended indications lower than the 90% target set by BASHH. 84.2% (n=85) of patients had PEPSE administered within 72 hours lower than the 90%. 61.4% (n=62) of patients were known to have completed four weeks of PEPSE lower than the 75% target. 61.4% (n=62) of patients were screened for sexually transmitted infections (STIs) lower than the 90% target. 59.4% (n=60%) of patients had post-PEPSE HIV bloods slightly lower than the 60% target.

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26

Waheed, Usman, Yetmgeta Eyayou Abdella, Noor e. Saba, Muhammad Arshad, Akhlaaq Wazeer, Ahmad Farooq, Javaid Usman, Abida Arshad, and Hasan Abbas Zaheer. "Evaluation of screening effectiveness of hepatitis B surface antigen and anti-HCV rapid test kits in Pakistan." Journal of Laboratory Physicians 11, no. 04 (October 2019): 369–72. http://dx.doi.org/10.4103/jlp.jlp_172_19.

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Abstract OBJECTIVE: The current study was conducted to evaluate the performance and screening effectiveness of commercially available rapid screening kits in comparison with chemiluminescence immunoassay (CLIA) and polymerase chain reaction (PCR). MATERIALS AND METHODS: This single-center, cross-sectional study was conducted at the Department of Pathology and Blood Transfusion Services, Shaheed Zulfiqar Ali Bhutto Medical University, PIMS, Islamabad, from January to April 2019. A total of 10 commercially available immunochromatographic test (ICT) devices and one CLIA kit (LIAISON XL) were tested for their sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy using 100 positive and 100 negative samples each for HBV and HCV, respectively. RESULTS: The sensitivities and specificities of ICT kits for hepatitis B surface antigen were 65% and 70% (Hightop), 67% and 85% (RightSign), 62% and 73% (Wondfo), 70% and 80% (Accu-Chek), 68% and 77% (Fastep), 73% and 85% (Abon), 77% and 83% (ImmuMed), 80% and 90% (Insta-Answer), 67% and 81% (BioCheck), and 72% and 83% CTK Biotech, respectively. Similarly, the sensitivities and specificities of different ICT kits for HCV were 69% and 80% (Hightop), 76% and 83% (RightSign), 69% and 81% (Wondfo), 78% and 79% (Accu-Check), 68% and 68% (Fastep), 63% and 73% (Abon), 71% and 70% (ImmuMed), 79% and 68% (Insta-Answer), 62% and 66% (BioChek), and 69% and 78% CTK Biotech, respectively. The sensitivity and specificity of Diasorin Liaison Murex assay for both HBV and HCV were found to be 100% when compared with PCR. The PPV, NPV and Accuracy were determined accordingly.CONCLUSION: Rapid testing ICT devices for both HBV and HCV available in Pakistan were found to have a variable degree of sensitivity and specificity when compared with CLIA and PCR. Comparatively expensive but quality methods are more reliable as compared to rapid devices.

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27

Vance, Hubert R., Norman Hankins, and Wesley Brown. "Predictive Validity of the MC Carthy Screening Test Based on Wide Range Achievement Test." Psychological Reports 59, no. 3 (December 1986): 1060–62. http://dx.doi.org/10.2466/pr0.1986.59.3.1060.

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The correlations between the McCarthy Screening Test and the Wide Range Achievement Test were assssed for 87 Caucasian first grade children from a semirural school district: 44 boys and 43 girls whose mean age was 62 mo. at screening and 83 mo. at achievement testing. Pearson product-moment correlations were moderate (.53 to .34) between McCarthy Numerical Memory and achievement and negligible (.03 to .16) between the McCarthy Leg Coordination and the achievement. Findings are discussed in relation to Meeker's technique of interpretation.

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28

Yumaroh, Iis, Erik Aditia Ismaya, and Eko Widianto. "Penerapan Model Think Pair Share Pada Tema Pahlawanku untuk Meningkatkan Hasil Belajar Siswa Kelas IV Sekolah Dasar." DIDAKTIKA: Jurnal Pendidikan Sekolah Dasar 3, no. 2 (December 12, 2020): 79–88. http://dx.doi.org/10.21831/didaktika.v3i2.33377.

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This research aims to determine increasing student learning outcomes in grade IV SD 5 Karangbener Kudus on theme 5 with Think Pair Share learning models assisted mosaic puzzle media. This class action research was carried out in grades IV SD 5 Karangbener with research subjects 24 students, which lasted for two cycles with each cycle consisting of two meetings. Each cycle consists of four stages, namely, planning, implementing, observing, and reflecting. The results showed an increase in learning activity and achievement. The value of student learning outcomes in the knowledge domain in pre-cycle scores 66 on social studies and 67 on Indonesian content with a percentage of 30% and 25%, cycle I score 73 with a percentage of 62% and increases in cycles II with a score of 81 with a percentage of 83%. For the pre-cycle speaking skill, students got a score of 338 with a percentage of 62%. In cycle I, students achieving a score of 401 with a percentage of 67%. Lastly, an increase in cycle II with a score of 466 with a percentage of 78%.Keywords: The Result of Learning, Themes My Hero, Model of Think Pair Share====================================================================================================Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar siswa kelas IV SD 5 Karangbener Kudus pada tema 5 dengan diterapkannya model pembelajaran Think Pair Share berbantuan media puzzle paku. Penelitian tindakan kelas ini dilaksanakan di kelas IV SD 5 Karangbener dengan subjek penelitian 24 siswa, yang berlangsung selama dua siklus, setiap siklusnya terdiri dari dua pertemuan. Setiap siklusnya terdiri dari empat tahapan yaitu perencanaan, pelaksanaan, pengamatan, dan refleksi. Teknik pengumpulan data meliputi teknik wawancara, observasi, tes, dan dokumentasi. Hasil penelitian menunjukan adanya peningkatan dalam pembelajaran. Nilai hasil belajar siswa ranah pengetahuan pada prasiklus memperoleh skor 66 pada muatan IPS dan 67 pada muatan Bahasa Indonesia dengan persentase 30% dan 25%, siklus I memperoleh skor 73 dengan persentase 62% dan meningkat pada siklus II dengan skor 81 dengan persentase 83%. Nilai keterampialan berbicara siswa prasiklus memperoleh skor 338 dengan persentase 62% pada siklus I mencapai skor 401 dengan persentase 67% dan meningkat pada siklus II dengan skor 466 dengan persentase 78%. Kata kunci: Hasil Belajar, Tema Pahlawanku, Model Think Pair Share

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29

Poletaev, G. M., and et al. "Effect of carbon and oxygen impurity atoms on the migration rate of triple junctions of tilt boundaries in FCC metals." Izvestiya vysshikh uchebnykh zavedenii. Fizika, no. 10 (October 1, 2019): 83–87. http://dx.doi.org/10.17223/00213411/62/10/83.

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30

McKittrick, LS, JB McKittrick, and TS Risley. "Transmetatarsal amputation for infection or gangrene in patients with diabetes mellitus. 1949." Journal of the American Podiatric Medical Association 83, no. 2 (February 1, 1993): 62–78. http://dx.doi.org/10.7547/87507315-83-2-62.

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31

Dillon, S. "Victorian Interior." Modern Language Quarterly 62, no. 2 (June 1, 2001): 83–116. http://dx.doi.org/10.1215/00267929-62-2-83.

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32

Currò, Sarah, Carmen L. Manuelian, Massimo De Marchi, Pasquale De Palo, Salvatore Claps, Aristide Maggiolino, Giuseppe Campanile, et al. "Autochthonous dairy goat breeds showed better milk quality than Saanen under the same environmental conditions." Archives Animal Breeding 62, no. 1 (February 28, 2019): 83–89. http://dx.doi.org/10.5194/aab-62-83-2019.

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Abstract. Studies on goat milk have mainly focused on cosmopolitan breeds and very limited information is available on local breeds, which is important for biodiversity preservation and local cheese production. The aim of this study was to evaluate the breed effect on milk yield, composition and somatic cell score (SCS) of five local Italian goat breeds (Garganica, Girgentana, Jonica, Maltese and Mediterranean Red) compared with a cosmopolitan specialized dairy breed (Saanen). A total of 60 goats (10 per breed) from an experimental farm were enrolled in the study. Milk yield, composition and SCS were recorded and analyzed every 2 weeks during the entire lactation. Data were analyzed using a mixed model with repeated measures. Saanen yielded between 0.27 and 0.62 kg day−1 more milk than the local breeds. Among local breeds, Maltese and Jonica were the most productive, with an average of 1.28 and 1.25 kg day−1, respectively, while Mediterranean Red, Garganica and Girgentana produced ≤1 kg day−1. Saanen had the highest SCS (6.81) and the lowest fat content (3.26 %). In relation to protein, Garganica showed the greatest content (3.71 %), and Saanen had a similar content to other local breeds (3.42 %) except for Maltese, which was lower (3.11 %). Saanen and Garganica had the lowest lactose percentage (4.28 % and 4.26 %, respectively). All breeds followed a similar pattern across lactation: SCS and fat and protein content peaked at the end of the lactation, whereas lactose percentage was highest at the beginning of the lactation. Differences between Saanen and the local breeds for milk yield, composition and SCS were consistent across lactation. In conclusion, local breeds produced less milk but with lower SCS and greater fat and lactose content than the Saanen cosmopolitan breed, suggesting a better milk quality.

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33

Dianat-Moghadam, Hassan, Maryam Heidarifard, Rana Jahanban-Esfahlan, Yunes Panahi, Hamed Hamishehkar, Farhad Pouremamali, Reza Rahbarghazi, and Mohammad Nouri. "Corrigendum to “Cancer stem cells-emanated therapy resistance: Implications for liposomal drug delivery systems”. [Journal of Controlled Release 288 (2018) 62–83]." Journal of Controlled Release 305 (July 2019): 220. http://dx.doi.org/10.1016/j.jconrel.2019.05.004.

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34

Alqatawneh, M. А., E. V. Zhuk, and P. I. Bespalchuk. "DEFORMATION AND CONTRACTURE OF KNEE JOINT." Medical Journal, no. 3(77) (2021): 12–18. http://dx.doi.org/10.51922/1818-426x.2021.3.12.

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The article provides a comparative analysis of the functional results of total knee arthroplasty and its postoperative deformity and contracture in 124 patients (22 men and 102 women) suffering from gonarthrosis, aged 51 to 83 years (average 69.8 years), operated on with using a standard technique (n = 62) or using a computer navigation system (n = 62), observed for 12 months, from the moment of surgery. The use of the navigation system made it possible in a number of cases to achieve more accurate resection of the femur and tibia (6.5 % of cases of deviations from the anatomical axis versus 19.4 % in the control group), as well as to determine the degree of deformity and severity of contracture to achieve the most optimal range of motion after endopresthetics (3.2 % versus 8.1 %), however, there was no evidence of a significant superiority of functional results within the indicated follow-up period.

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Mitchem, Wayne E., David W. Monks, and Robert J. Mills. "Response of Transplanted Watermelon (Citrullus lanatus) to Ethalfluralin Applied PPI, PRE, and POST." Weed Technology 11, no. 1 (March 1997): 88–91. http://dx.doi.org/10.1017/s0890037x00041397.

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Field experiments conducted in 1992 and 1993 evaluated transplanted watermelon tolerance to ethalfluralin applied PPI, PRE (before transplanting), and POST (immediately after transplanting) at 1.2 or 2.4 kg ai/ha. Other treatments for comparison included the registered herbicides ethalfluralin POST-directed spray (PDS), ethalfluralin PDS followed by (fb) naptalam POST, bensulide plus naptalam PPI, and a nontreated check. All treatments controlled common lambsquarters and goosegrass 83 to 100% 2 and 6 weeks after treatment (WAT). Watermelon was injured 30 to 77% in 1992 and 14 to 83% in 1993 by ethalfluralin PPI or PRE at 1.2 or 2.4 kg/ha. Ethalfluralin POST was not injurious to watermelon. In 1992, watermelon treated with ethalfluralin POST at 1.2 and 2.4 kg/ha yielded 52 to 62% more fruit than watermelon from the nontreated check. In 1993, yield of transplanted watermelon treated with ethalfluralin POST was similar to that in the nontreated check.

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36

Gronenborn, A. M., R. Sandulache, S. Gärtner, and G. M. Clore. "Mutations in the cyclic AMP binding site of the cyclic AMP receptor protein of Escherichia coli." Biochemical Journal 253, no. 3 (August 1, 1988): 801–7. http://dx.doi.org/10.1042/bj2530801.

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Mutants in the cyclic AMP binding site of the cyclic AMP receptor protein (CRP) of Escherichia coli have been constructed by oligonucleotide-directed mutagenesis. They have been phenotypically characterized and their ability to enhance the expression of catabolite-repressible operons has been tested. In addition, the binding of cyclic nucleotides to the mutants has been investigated. It is shown that the six mutants made fall into one of three classes: (i) those that bind cyclic AMP better than the wild type protein (Ser-62→Ala) and result in greater transcription enhancement; (ii) those that bind cyclic AMP similarly to wild type (Ser-83→Ala, Ser-83→Lys, Thr-127→Ala, Ser-129→Ala); and (iii) those that do not bind cyclic AMP at all (Arg-82→Leu). Implications of these findings with respect to present models of the cyclic nucleotide binding pocket of CRP are discussed.

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37

Mandia, Jeremy, Freddy Escorcia, Holly Ning, Kilian Elizabeth Salerno, Deborah E. Citrin, and Lindsay S. Rowe. "Bowel and bladder reproducibility in image-guided SBRT prostate: Results of a patterns of practice survey." Journal of Clinical Oncology 37, no. 7_suppl (March 1, 2019): 76. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.76.

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76 Background: Use of prostate stereotactic body radiotherapy (SBRT) as treatment for localized prostate cancer (PCa) is increasing. Given the high dose (>5Gy) per fraction (Fx) being delivered, SBRT requires careful preparation and delivery to ensure accuracy and precision. Guidelines and data on best practice for bowel and bladder preparation are lacking. Therefore, we surveyed practicing radiation oncologists (RO) to document practice patterns for prostate SBRT. Methods: From June to October 2018 we completed a nationwide survey of 1395 American Society for Therapeutic Radiology and Oncology (ASTRO) members who self-identified as managing PCa. A SurveyMonkey link was sent via email, and analysis included practicing RO who treat PCa with SBRT. Results: 204 responses were received with 32% (64/204) using SBRT. 80% (51/64) provided the fractionation used: 33% (17/51) use 35Gy to 36.25Gy, and 17.6% (9/51) use >40Gy in 5 Fx, and 1 used >9Gy Fx. 94% use implantable devices for localization (83% fiducial markers, 17% radiofrequency transponders). 65% (42/64) use a hydrogel spacer. 75% (48/64) use daily cone beam CT (CBCT) for image guidance. The majority use a 5 mm PTV, with 3 mm posteriorly. For bladder and bowel preparation 97% (62/64) provided preferences. For bladder, 90.3% (56/62) required a comfortably full bladder for both simulation and treatment. For simulation, 92% (57/62) have a bowel protocol (BP) to optimize rectal reproducibility. 51.6% (31/62) have patients empty their bowels prior, and 51.6% (31/62) prescribe a BP. Diet alteration was recommended by 77% (48/62). 86% (53/62) used a BP during SBRT treatment. Of those using a BP, 67% (43/64) continued it throughout SBRT with 30% (19/64) continuing BP unless symptoms change management. Only 3% (2/64) stop BP after simulation. Conclusions: The variability of data in the literature on effective BP for treatment reproducibility for PCa is reflected in the varied patterns of practice seen in our survey. Consensus on bladder preparation is seen for a majority of practitioners. A variety of BP regimens are employed.

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38

Chizzola, Remigius. "Composition of the Essential Oil of Wild Grown Caraway in Meadows of the Vienna Region (Austria)." Natural Product Communications 9, no. 4 (April 2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900440.

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The essential oil compositions of the different plant parts of wild growing caraway (Carum carvi, Apiaceae) were analyzed by GC/MS and GC/FID. The plants came from two meadows in the Vienna region, Austria. The oils from young fruits had a high proportion of limonene (61-83%), and those from inflorescences limonene (39-62%) and germacrene D (23-41%). The carvone contents of fruits, inflorescences and leaves varied greatly. Leaves and stems, low in volatiles, were dominated by germacrene D and germacrene A. Therefore, wild caraway appears as a valuable aromatic herb in meadows.

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39

Azania, A. A. P. M., C. A. M. Azania, R. Gravena, M. C. M. D. Pavani, and R. A. Pitelli. "Interferência da palha de cana-de-açúcar (Saccharum spp.) na emergência de espécies de plantas daninhas da família convolvulaceae." Planta Daninha 20, no. 2 (August 2002): 207–12. http://dx.doi.org/10.1590/s0100-83582002000200006.

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Este trabalho foi conduzido na Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal-UNESP, com o objetivo de estudar o efeito de diferentes quantidades de palha de cana-de-açúcar deixadas na superfície do solo sobre a emergência de algumas espécies de plantas daninhas pertencentes à família Convolvulaceae. Os tratamentos foram distribuídos no esquema de parcelas subsubdivididas, com a quantidade de palha nas parcelas de 0, 5, 10, 15 e 20 t ha-1, as variedades SP 79 2233 e RB 83 5486 nas subparcelas e as espécies de plantas daninhas nas subsubparcelas. Aos 45 dias após semeadura (DAS), a presença de 15 t ha-1 de palha reduziu em 46 e 62% o número de plantas de I. quamoclit e M. cissoides, respectivamente. Entretanto, a presença de 20 t ha-1 reduziu em 82, 65, 62, 70, 60 e 88% o número de plantas de I. quamoclit, I. purpurea, I. grandifolia, I. hederifolia, I. nil e M. cissoides, respectivamente, quando comparadas à ausência de palha.

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40

Palmer, S. R., and Anne H. B. Biffin. "The changing incidence of human hydatid disease in England and Wales." Epidemiology and Infection 99, no. 3 (December 1987): 693–700. http://dx.doi.org/10.1017/s0950268800066553.

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SUMMARYThe incidence of hospital-diagnosed human hydatid disease acquired in the UK was estimated from a survey based on Hospital Activity Analysis data for the period 1974–83. The average annual incidence in Wales was 0·4 per 100000 population compared with 0·02 per 100000 in England. Within Wales, Powys, and particularly Brecknock, had the highest incidence (7 per 100000 per year). Compared with the period 1953–62, the average annual incidence for Wales fell by half (from 0·8 to 0·4 per 100000 per year), but in Powys the incidence did not decline, and in Brecknock and Montgomery there was a marginal increase. In comparison with 1953–62, the age-specific incidence in Wales and Powys decreased in each age group with the notable exception of children < 15 years of age. This finding emphasizes that transmission of Echinococcus granulosus to humans is still occurring at hyper-endemic levels in parts of England and Wales and that control efforts should be intensified.

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Mery, Alexandre, Boualem Sendid, Nadine François, Marjorie Cornu, Julien Poissy, Yann Guerardel, and Daniel Poulain. "Application of Mass Spectrometry Technology to Early Diagnosis of Invasive Fungal Infections." Journal of Clinical Microbiology 54, no. 11 (September 7, 2016): 2786–97. http://dx.doi.org/10.1128/jcm.01655-16.

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We recently developed a mass spectrometry (MS) procedure based on the detection of a serum disaccharide (MS-DS) in patients with invasive candidiasis (IC). Here, we compare the performance of MS-DS for the diagnosis of IC, invasive aspergillosis (IA), and mucormycosis (MM) with those of commercially available antigen detection tests. This retrospective study included 48 patients (23 IC patients [74 serum samples], 15 IA patients [40 serum samples], and 10 MM patients [15 serum samples]) and 49 appropriate controls (102 serum samples). MS-DS, mannan (Mnn), galactomannan (GM), and (1,3)-β-d-glucan (BDG) were detected by matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) MS, Platelia, and Fungitell assays, respectively. For IC, the sensitivity and specificity of the MS-DS index, BDG detection, and Mnn detection were 62% and 84%, 82% and 60%, and 33% and 94% per serum sample and 83% and 69%, 96% and 31%, and 39% and 86% per patient, respectively. For IA, the corresponding values in comparison to BDG and GM detection were 83% and 81%, 62% and 95%, and 62% and 100% per serum sample and 93% and 76%, 87% and 90%, and 93% and 100% per patient, respectively. Nine of the 10 MM patients had a positive MS-DS result. MS-DS gave an early diagnosis in IC (73% positivity before blood culture), IA (positive before GM detection in six patients), and MM (positivity mainly preceded the date of diagnosis) patients. For IC, persisting MS-DS was associated with a poor prognosis. The different biomarkers were rarely detected simultaneously, suggesting different kinetics of release and clearance. For IA, MS-DS provided better complementation to GM monitoring than BDG monitoring. MS-DS detects panfungal molecules circulating during invasive fungal infections. The performance of MS-DS compared favorably with those of biological tests currently recommended for monitoring at-risk patients. Further validation of this test in multicenter studies is required.

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Cavalcante, Pedro Henrique Noronha, Gabriel Henrique Soares Cavalcante, Ricardo Roberto de Souza Fonseca, Tabata Resque Beckmann Carvalho, Silvio Augusto Fernandes De Menezes, Paula Mendes Acatauassú Carneiro, Marcelo Newton Carneiro, Michel Wagner de Souza Matos, Gyselle Ribeiro De Carvalho Oliveira, and Tatiany Oliveira De Alencar Menezes. "Avaliação das condições de saúde bucal de pessoas com fissuras labiopalatinas em Belém, norte do Brasil." Revista Eletrônica Acervo Saúde 13, no. 4 (April 24, 2021): e7064. http://dx.doi.org/10.25248/reas.e7064.2021.

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Objetivo: Avaliar as condições de saúde bucal de pessoas com fissura labiopalatinas (PFLP) atendidos em um centro especializado em Belém-PA. Métodos: Pesquisa de caráter transversal com análises descritiva, quantitativa e qualitativa na Associação de Apoio ao Fissurado Labiopalatal Sorrisos Largos (AAFLSL), pelo exame clínico da cavidade oral e registros de prontuários de 29 associados PFLP, de todas as idades e ambos os sexos, cadastrados na (AAFLSL). Levou-se em consideração: Presença de cárie, prevalência dos tipos de fissuras, presença de hábitos deletérios, período de internação e reparação cirúrgica das fissuras. Os dados foram calculados por frequência absoluta e relativa no Microsoft excel®. Resultados: Das PFLP avaliadas; houve prevalência do sexo masculino. 62% estão livres de cárie. A fissura transforame unilateral completa demonstrou maior incidência. Cerca de 62% possuem algum hábito deletério. 83% passaram por período de internação nos 2 últimos anos. Quanto as cirurgias reparadoras, cerca de 82% já passaram pela queiloplastia e 62% passaram pela palatoplastia Conclusão: Os dados obtidos mostram condições satisfatórias de saúde bucal das pessoas analisadas, entretanto a presença de hábitos parafuncionais é um fator de risco à saúde. Por fim, conhecer o perfil do paciente fissurado é essencial para que sejam estabelecidos protocolos de tratamentos.

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Fachetti-Machado, Giselle, Rosane Figueiredo-Alves, and Marise Moreira. "Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 40, no. 07 (July 2018): 410–16. http://dx.doi.org/10.1055/s-0038-1666995.

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Objective To estimate the cytological and colposcopic performances for the diagnosis of cervical neoplasias. Methods Cross-sectional retrospective study with data from patients' charts. The participants underwent colposcopy, guided biopsies, and excision when needed. The cytological and colposcopic categorization followed the Bethesda System and the international colposcopic terminologies. The cytology and colposcopy performances were evaluated by sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV) analyses with 95% confidence interval (95% CI). Results From 1,571 participants, a total of 1,154 (73.4%) were diagnosed with cervical squamous intraepithelial neoplasia grade 2 or worse (CIN 2+), 114 (7.2%) with adenocarcinoma in situ or worse (AIS+), 615 (39.2%) presented atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion or worse (ASC-H+) cytology, and 934 (59.4%) presented major or suspicious for invasion colposcopic abnormalities. The SE, SP, PPV, and NPV of ASC-H+ for diagnoses of CIN 2+ and AIS+ were, respectively: 44% (95% CI: 41–47) and 72% (95% CI: 67–76), 79% (95% CI: 77–81) and 79% (95% CI: 75–83), 88% (95% CI: 87–90) and 55% (95% CI: 50–60), and 28% (95% CI: 26–31) and 88% (95% CI: 85–91). The SE, SP, PPV, and NPV of major or suspicious for invasion colposcopic abnormalities for diagnoses of CIN 2+ and AIS+ were, respectively: 62% (95% CI: 60–65) and 86% (95% CI: 83–89), 59% (95% CI: 57–62) and 59% (95% CI: 55–64), 85% (95% CI: 83–87) and 44% (95% CI: 40–49), and 29% (95% CI: 27–32) and 92% (95% CI: 89–94). Conclusion The SE analyses results of ASC-H+ and major or suspicious for invasion colposcopic abnormalities were higher for diagnoses of glandular neoplasias. These results confirm the role of cytology in identifying women at risk who will have their final diagnoses settled by colposcopy and histology.

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RIVAS, I., I. LATORRE, A. SANVISENS, J. DOMÍNGUEZ, J. TOR, C. PRAT, C. REY-JOLY та R. MUGA. "Prospective evaluation of latent tuberculosis with interferon-γ release assays in drug and alcohol abusers". Epidemiology and Infection 137, № 9 (26 лютого 2009): 1342–47. http://dx.doi.org/10.1017/s0950268809002131.

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SUMMARYIn vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39·8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon-γ assays were positive in 34% of patients with an agreement of 83% (κ=0·63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon-γ assays was 85% (κ=0·62) and 83% (κ=0·57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease.

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El-Mahallawy, Hadir Ahmed, Rana El-Gendi, Doaa Mohammad Ghaith, Iman Kamal Behiry та Soheir Fathy Helal. "Galactomannan and 1, 3-β-D-Glucan Assay in Bronchoalveolar Lavage Fluid for the Diagnosis of Invasive Pulmonary Aspergillosis in Malignant and Non-malignant Patients". Open Access Macedonian Journal of Medical Sciences 9, A (2 червня 2021): 362–66. http://dx.doi.org/10.3889/oamjms.2021.5994.

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BACKGROUND: Serum 1, 3-β-D-glucan (BDG) assay was recommended for diagnosing fungal infections. AIM: We aimed to assess 1, 3-β-D-glucan in bronchoalveolar lavage (BAL) fluid in invasive pulmonary aspergillosis (IPA). METHODS: Out of 104 patients clinically suspected fungal, 45 were probable, 18 possible, and 41 unlikely according to EORTC/MSG 2008 criteria. Measuring BAL BDG and galactomannan were done. RESULTS: The sensitivity, specificity, and positive and negative predictive values (PPV and NPV) for BDG were 44%, 71%, 62%, and 54%; for galactomannan 84%, 83%, 84%, and 83%; and 93%, 66%, 75%, and 90%, respectively, when combining both tests. A significant different performance of GM; p = 0.0008 was detected in patients with malignant disorders when compared to non-malignant; but not for BDG; p = 0.121. CONCLUSION: We can conclude that BAL-BDG is helpful if positive in a clinically suspected IFI case, but if negative cannot rule out fungal infection. Thus, combining results of BAL-GM and BAL-BDG are recommended.

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Albenzio, Marzia, and Mariangela Caroprese. "Differential leucocyte count for ewe milk with low and high somatic cell count." Journal of Dairy Research 78, no. 1 (December 7, 2010): 43–48. http://dx.doi.org/10.1017/s0022029910000798.

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This study was undertaken to compare flow cytometry (FC) and direct microscopic leucocyte count (MDLC) for the differentiation of macrophages, lymphocytes and polymorphonuclear leucocyte (PMN) and to evaluate leucocyte distribution in ewe milk with low and high somatic cell count (SCC). Milk samples were grouped for somatic cell count in low SCC (LSCC) when the content was lower than 5·00×105/ml and high SCC (HSCC) when the content was higher than 1·00×106/ml. No differences were found between the two methods tested suggesting that FC could be used as a routine test for rapid discrimination of leucocytes. Percentages of lymphocytes in ewe milk were higher in LSCC (50%) than in HSCC (39%) and count ranged from 273·91±56·62×103cells/ml (LSCC) to 308·90±46·15×103cells/ml (HSCC). PMN number was lower in LSCC than in HSCC (248·83±46·87×103cells/ml v. 444·38±58·62×103cells/ml); accordingly the percentage was lower in LSCC (40%) than in HSCC (57%). No differences were found for macrophages which were 36·36±5·51×103cells/ml and 39·32±6·83×103cells/ml in LSCC and HSCC, respectively. Lymphocytes in ewe milk did not vary with increased number of somatic cells and were the predominant cell type in LSCC. PMN represented the main population detected in HSCC and the correlation with SCC evidenced that this leucocyte class could be useful in differentiating ewe milk cell count, being strictly responsible for the SCC increase.

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Bennett, Charles L., Thanh Ha Luu, Anaadriana Zakarija, Hau C. Kwaan, Nicholas Bandarenko, Dilip K. Pandey, John F. Cursio, et al. "Clinical and Outcomes Findings for Thrombotic Thrombocytopenic Purpura among 467 Persons with Severely Versus Not Severely Deficient ADAMTS-13 Levels." Blood 110, no. 11 (November 16, 2007): 2088. http://dx.doi.org/10.1182/blood.v110.11.2088.2088.

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Abstract Background: Thrombotic thrombocytopenic purpura (TTP) is a rare disorder that presents with microangiopathic hemolytic anemia and thrombocytopenia, fevers, renal insufficiency and neurologic features. We reviewed clinical, laboratory, and outcome data for TTP cases with severely deficient versus non-severely deficient ADAMTS13 activity levels. Methods: Mean and median data were from the Surveillance, Epidemiology and Risk Factors for TTP (SERF-TTP) study group for idiopathic TTP cases, the Canadian Apheresis Group (CAG), and five published series (Zheng 2004, Raife 2004, Vesely 2003 (Oklahoma TTP-HUS Registry), Matsumoto 2004 (Japan Referral Center), Bennett 2007). Results: Compared to TTP cases with near-normal ADAMTS13 activity levels (n= 282), TTP cases with severe ADAMTS13-deficiency (n=185) were more likely to have severe thrombocytopenia, normal renal function and neutralizing ADAMTS13 antibodies. Severe ADAMTS13 deficient TTP cases have better overall survival after therapeutic plasma exchange (TPE) but are more likely to relapse. TTP patients with severe ADAMTS13 deficiency were primarily categorized as idiopathic or ticlopidine-associated, while TTP patients with non-severely deficient ADAMTS13 activity levels were frequently categorized as idiopathic, secondary to drugs (clopidogrel, quinine), stem cell transplantation, or cancer. Conclusions: Severe ADAMTS13 deficiency is most commonly idiopathic, has better survival following TPE, and a 35–40% spontaneous relapse rate. By contrast, non-ADAMTS13 deficient TTP cases are usually associated with an underlying disorder or external insults. Amongst this cohort, four series have 47–62% survival rates and three series, which contain mostly idiopathic cases, have 83–90% survival rates following TPE. From this, we propose that TTP may occur by three possible mechanism; ADAMTS13-deficient (antibody-mediated), an immunologic mediated pathway independent of ADAMTS13 (i.e. quinine) that is responsive to TPE, and endothelial injury related TTP that is unresponsive to TPE. Platelet count mean (x10^9/L) Creatinine mean (mg/dl) ADAMTS13 neutralizing antibodies (%) Survival % Relapse % * <15% ADAMTS13 activity cutoff Severe ADAMTS13 Deficiency (<10–15%) SERF-TTP (n=30) 19 1.3 83 97 41 Zheng (n=16) 19 1.6 44 81 38 Bennett (n=26) 15 85 Oklahoma (n=18) 12 1.8 94 81 38 Raife (n=50) * 13 1.2 92 35 Japan (n=34) 35 91 Canada (n=11) 16 2.4 82 Not Severely Deficient ADAMTS13 Activity (> 15%) SERF-TTP (n=22) 57 3.9 35 90 0 Raife (n=57) * 44 2.7 83 9 Canada (n=17) 57 4.1 88 Zheng (n=13) 40 3.0 0 54 Bennett (n=13) 62 Japan (n=66) 9 62 Oklahoma (n=94 ) 23 47 3

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Wilczynski, Ophélie, Anthony Boisbouvier, Lise Radoszycki, François-Emery Cotté, Anne-Françoise Gaudin, and Hervé Lemasson. "Integrating Quality of Life in the Care Pathway of Cancer Patients Undergoing Immunotherapy Treatment: Descriptive, Cross-sectional Survey of an Online Patient Community's Experiences and Expectations." Journal of Medical Internet Research 24, no. 1 (January 11, 2022): e25792. http://dx.doi.org/10.2196/25792.

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Background New cancer treatments, such as immune checkpoint inhibitors (ICIs), can improve survival and health-related quality of life (HRQoL) in patients with cancer. Although long-term monitoring of HRQoL has been shown to improve survival, integration of HRQoL into everyday practice remains poorly documented. Objective This study describes experiences and expectations of patients treated with ICIs regarding a discussion of HRQoL with health care professionals (HCPs) in cancer management. Methods This cross-sectional study was conducted in an online patient community (Carenity) in France. Patients treated with ICIs for cancer, included between September 2018 and January 2019, completed a questionnaire to assess the involvement of HCP in a discussion of HRQoL and when and what was discussed. Results Of 82 patients included (mean age: 56.9 years, 95% CI 54.2-59.6; 46 [56%] male; 34 [41%] with lung cancer), 62 (76%) reported discussing HRQoL at least once with HCPs, mainly general practitioners (54/82, 66%), oncologists (53/82, 65%), and hospital nurses (50/82, 61%). Around half (45/82, 55%) of the patients were satisfied with these discussions. Discussions with the oncologist were at the patient’s initiative (34/53, 64%). Discussions occurred primarily during follow-up visits (40/62, 65%), when adverse events occurred (30/62, 48%), and at treatment initiation (27/62, 32%). The most discussed dimensions were symptoms (48/62, 77%) and physical well-being (43/62, 69%). With respect to expectations, 54/82 (66%) patients considered oncologists as the most important HCPs for discussing HRQoL. These discussions were desirable throughout the care pathway, particularly at diagnosis (63/82, 77%) and when treatment was initiated (75/82, 92%) or changed (68/82, 83%). All HRQoL dimensions were considered important to discuss. Conclusions With only around half of the patients satisfied with HRQoL discussions, impactful HRQoL integration in clinical practice is critical. According to patients, this integration should involve mainly oncologists and general practitioners, should happen at every step of the care pathway, and should be extended to dimensions that are currently rarely addressed.

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Grundtvig, N. F. S. "Clara." Grundtvig-Studier 37, no. 1 (January 1, 1985): 9–10. http://dx.doi.org/10.7146/grs.v37i1.15939.

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ClaraBy N. F. S. GrundtvigGrundtvig published this poem in his periodical The Dane on November 8th 1848. It is reprinted here as it appeared in the original edition. Clara is a description of his meeting with a woman in a foreign country, whom he met once only but who according to another poem, The Little Ladies, inspired much of his later poetry. Her importance for Grundtvig has been described in detail by Kaj Thaning in his thesis, Man First - (1963, see esp. pp. 220-31) An earlier treatment is by J. P. Bang in Grundtvig and England (1932 pp. 62-83).

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Nwanzu, Chiyem Lucky, and Sunday Samson Babalola. "Predictive Relationship between Sustainable Organisational Practices and Organisational Effectiveness: The Mediating role of Organisational Identification and Organisation-Based Self-Esteem." Sustainability 11, no. 12 (June 22, 2019): 3440. http://dx.doi.org/10.3390/su11123440.

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This study ascertains the predictive relationship that sustainable organisational practices have with organisational effectiveness and the mediating role of organisational identification and organisation-based self-esteem in this relationship. One-hundred and forty-five participants (62 males and 83 females) were sampled from 31 privately-owned organisations in Delta State, Nigeria. Regression analysis revealed that sustainable organisational practices positively and significantly predict organisational effectiveness, β = 0.42, p < 0.001, and that organisational identification and organisation-based self-esteem mediate the relationship. It was recommended that privately-owned organisations intensively implement sustainable organisational practices for organisational effectiveness, organisational identification and organisation-based self-esteem.

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