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1
Alves, L., E. A. Mendoza, and G. N. Silva Filho. "Microrganismos solubilizadores de fosfatos e o crescimento de pínus e eucalipto." Revista Brasileira de Ciência do Solo 26, no. 4 (December 2002): 939–47. http://dx.doi.org/10.1590/s0100-06832002000400011.
Повний текст джерелаАнотація:
Os microrganismos solubilizadores de fosfatos desempenham importante papel no suprimento de fósforo para as plantas. Isso tem motivado pesquisas em programas de inoculação controlada. O processo de seleção envolve várias etapas. Microrganismos isolados de cultivos de Pinus e Eucalyptus e selecionados em meio de cultura foram avaliados em 28 experimentos realizados em casa de vegetação com substrato ou solo de floresta ou de viveiro, esterilizados, sem ou com adubação fosfatada (fosfato monocálcico, fosfato de Araxá ou de Catalão). Em relação à produção de matéria seca, em um experimento, houve efeito positivo de três isolados (177, 251 e 310A); em outro, verificou-se efeito negativo de dois isolados (177 e 261). No teor de P no tecido foi verificado efeito positivo em sete tratamentos, envolvendo oito isolados (62, 177, 189, 198, 251, 262, 310A e 310B) e dois efeitos negativos (177 e 198). Quanto ao conteúdo de P na planta, foram verificados efeitos positivos em quatro experimentos, envolvendo os isolados 62, 189, 198, 251 e 310A. Os resultados obtidos na nutrição e no crescimento das plantas com a inoculação dos isolados 62, 189, 251 e 310A indicam a existência de potencial para ser utilizado em processos de seleção que visem à produção de inoculantes.
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Cordes, J. G. "Erratum: ‘‘Nonrelativistic calculation of the radiation emitted by a pair of identical particles’’ [Am. J. Phys. 62 (3), 251–254 (1994)]." American Journal of Physics 63, no. 10 (October 1995): 958. http://dx.doi.org/10.1119/1.18099.
Повний текст джерела
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Ciríaco, Jovana G. M., Paula L. Alexandre, Cristiana B. Pereira, Yuan P. Wang, and Milberto Scaff. "Vertigem postural fóbica: aspectos clínicos e evolutivos." Arquivos de Neuro-Psiquiatria 62, no. 3a (September 2004): 669–73. http://dx.doi.org/10.1590/s0004-282x2004000400019.
Повний текст джерелаАнотація:
A vertigem postural fóbica (VPF), o segundo diagnóstico mais freqüente em ambulatório de distúrbios vestibulares, é síndrome somatoforme caracterizada por desequilíbrio subjetivo e ataques breves de vertigem em situações específicas. Em período de 18 meses, a VPF foi observada em 41 pacientes, de 251 atendidos. Vinte e seis apresentavam VPF primária; em 65% havia distúrbios de ansiedade ou depressão, e 15 pacientes tiveram diagnóstico de VPF secundária. O exame neurológico e a avaliação complementar foram normais na maioria dos casos. Observou-se resposta favorável ao tratamento (antidepressivos, benzodiazepínicos, psicoterapia e/ou orientações) em 62% dos pacientes, sem diferença entre os grupos de VPF primária e VPF secundária. Apesar da alta prevalência, a VPF é subdiagnosticada. Entretanto, seu reconhecimento é importante para o tratamento adequado, evitando recorrência e incapacitação.
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Vandresen, Fabio, Sabrina Alencar de Almeida-Batista, Maria Eduarda Bueno Caldeira, Richard de Albuquerque Felizola Romeral, Celso Vataru Nakamura, Ana Lucia Tasca Góes Ruiz, and Cleuza Conceição da Silva. "Antitumor and antileishmanial activities of limonene-thiosemicarbazones bearing heterocycles nucleous." Research, Society and Development 11, no. 5 (March 31, 2022): e11711528152. http://dx.doi.org/10.33448/rsd-v11i5.28152.
Повний текст джерелаАнотація:
In the present study, we provided the synthesis of a series of R-(+)- and S-(-)-limonene-based thiosemicarbazones containing different pentacyclic heterocyclic nucleus moiety focused in the search of novel antitumor and antileishmanial agents. In the antitumor assay, the derivative imidazole of S-(-)-limonene 8 was the most active compound, especially for U-251, UACC-62 and K562 human tumor cell lines with GI50 ranging from 1.0 to <0.25 µg.mL-1. On the other hand, the imidazole-thiosemicarbazone of R-(+)-limonene 4 was the most promising derivative against the promastigote form of L. amazonensis (IC50=5.9µM). Meanwhile, thiosemicarbazones without limonene moiety (9-12) showed the lowest activities in the biological assays performed. The results demonstrated the influence of the lipophilic molecular character and stereochemistry of chiral monoterpene on the evaluated activities.
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Calderón-Soto, Claudia Alejandra, Marco Aurelio Correa-Munera, Diego Andrés Caicedo-Araujo, Javier Aldana-García, and Oscar Mauricio López-Floriano. "Colección viva del Jardín Botánico de la Universidad de la Amazonia Florencia – Caquetá / Living collection of the Universidad de la Amazonia Botanical Garden, Florencia – Caquetá." Brazilian Journal of Animal and Environmental Research 4, no. 4 (December 21, 2021): 6502–16. http://dx.doi.org/10.34188/bjaerv4n4-130.
Повний текст джерелаАнотація:
Se presenta un listado de especies de plantas vasculares presentes en el Jardín Botánico Uniamazonia (JBUDLA), ubicado en el campus Centro en Florencia – Caquetá. Se inventarió y se actualizó el número de especies botánicas empleando el formato único para el registro de colecciones vivas, donde el objetivo principal fue documentar y dar continuidad a la ejecución del plan de manejo de las colecciones vivas del jardín Botánico Uniamazonia. La información obtenida en este inventario se sistematizó de acuerdo a lo requerido por el Instituto de investigación en Recursos Biológicos Alexander von Humboldt en la plantilla “Darwin Core”, para ser subidas al SIB Colombia y el GBIF. Se registraron un total de 1.614 individuos, pertenecientes a 251 especies, 180 géneros y 62 familias, de las cuales las de mayor riqueza fueron Fabaceae con 29 especies, Araceae con 23, Orquidaceae con 18, Arecaceae con 14, Moraceae con 10, Rubiaceae con 8 y Euphorbiaceae con 4 especies.
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Mammen, Joy John, Edwin Sam Asirvatham, Jeyaseelan Lakshmanan, Charishma Jones Sarman, Arvind Pandey, Varsha Ranjan, Bimal Charles, et al. "The clinical demand and supply of blood in India: A National level estimation study." PLOS ONE 17, no. 4 (April 6, 2022): e0265951. http://dx.doi.org/10.1371/journal.pone.0265951.
Повний текст джерелаАнотація:
Background Estimating the clinical demand for blood and components arising in a health facility is crucial to ensure timely availability of blood. This study aims to estimate disease-specific clinical demand, supply and utilization of whole blood and components in India. Methods We conducted a national level cross-sectional study in five randomly selected states from five regions of the country. We included 251 public and private facilities representing primary, secondary and tertiary care facilities. We collected annual disease-specific demand, supply and utilization of blood and components using a structured tool. We estimated the national demand by extrapolating the study data (demand and beds) to the total number of estimated beds in the country. Findings According to the study, the total clinical demand of 251 health facilities with 51,562 beds was 474,627 whole blood units. Based on this, the clinical demand for India was estimated at 14·6 million whole blood units (95 CI: 14·59–14·62), an equivalent of 36·3 donations per 1,000 eligible populations, which will address whole blood and component requirement. The medicine specialty accounted for 6·0 million units (41·2%), followed by surgery 4·1 million (27·9%), obstetrics and gynecology 3·3 million (22·4%) and pediatrics 1·2 million (8·5%) units. The supply was 93% which is equivalent to 33·8 donations against the demand. Conclusion The study indicated a demand and supply gap of 2.5 donations per 1,000 eligible persons which is around one million units. The gap emphasises the need for sustained and concerted efforts from all stakeholders and for increasing the awareness about repeat voluntary non-remunerated blood donation (VNRBD); optimizing the availability of blood components through efficient blood component separation units; promoting modern principles of patient blood management and strengthening capacities of human resources in the blood transfusion system in India.
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Le Lay, Maëline. "La Plume vivante : revue littéraire congolaise, (Kinshasa), n°2 (Regards sur Benjamin Fondane), mars-avril-mai 2017, 62 p. – ISBN 978-2-35270-251-1." Études littéraires africaines, no. 46 (2018): 218. http://dx.doi.org/10.7202/1062301ar.
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Headley, David B., and Robert G. Mower. "Evaluating Tree Canopy Color Using Computerized Microdensitometry." Journal of the American Society for Horticultural Science 115, no. 1 (January 1990): 189–94. http://dx.doi.org/10.21273/jashs.115.1.189.
Повний текст джерелаАнотація:
The color of a tree's canopy can provide much information about the tree's physiological status as well as its aesthetic function. We present a system for the qualitative and quantitative analysis of tree canopy color, based on a previously published algorithm. This algorithm determines (with a known accuracy) the Munsell hue, value, and chroma of a color using densitometric readings obtained through the use of color separation filters. This method was adapted for use with black-and-white video images. Combining the Rib algorithm with the techniques of photography, video imagery, scanning microdensitometry, and batch data computer processing, a semi-automated system was devised for the pixel-by-pixel color evaluation of a 512 × 512-pixel image. Based on a sample of 251 color chips, the following accuracies were obtained: Munsell hue—86%, Munsell value—93%, Munsell chroma—70%, and Munsell color—62%. An example is provided that demonstrates how this system may be used to determine tree canopy color. By employing this technique, an estimation may be made of the colors and their relative quantities that are displayed by a tree's canopy.
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Palmbos, Phillip Lee, Scott A. Tomlins, Neeraj Agarwal, Przemyslaw Twardowski, Alicia K. Morgans, William Kevin Kelly, Vivek Arora, et al. "Cotargeting AR signaling and cell cycle: A randomized phase II study of androgen deprivation therapy with or without palbociclib in RB-positive metastatic hormone sensitive prostate cancer (mHSPC)." Journal of Clinical Oncology 36, no. 6_suppl (February 20, 2018): 251. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.251.
Повний текст джерелаАнотація:
251 Background: Palbociclib, a CDK4/6 inhibitor, blocked proliferation and promoted G1 arrest in an Rb and Cyclin D dependent manner in preclinical models of HSPC. Alterations in this pathway contribute to the development of CRPC. We hypothesized that co-targeting AR (ADT) and cell cycle (palbociclib) would improve outcomes including PSA RR at 28 weeks in mHSPC pts. Methods: mHSPC pts with Rb intact tumors based on IHC of metastatic biopsy were stratified and randomized (1:2) to Arm A: ADT or Arm B: ADT+ palbociclib (125mg 3 weeks on, 1 week off). Primary endpoint is confirmed PSA RR (≤ 4 ng/mL) after 28 weeks of therapy. With 20 patients randomized to ADT and 40 to ADT + palbociclib there is a 64.2% power to detect a 20% difference in proportions with a one-sided type I error of 0.10 using the mid p-value method of the Fisher’s exact test. Secondary endpoints include safety/tolerability, biochemical and clinical PFS, PSA and radiographic RR and exploratory biomarkers (circulating DNA, tumor cells and transcriptome). Results: 72 eligible pts (median age 67, PSA 73ng/mL) with newly diagnosed mHSPC were registered and underwent biopsy (41 soft tissue, 31 bone). 64/72 (90%) had adequate tissue for RB assessment and 62/64 (97%) retained RB expression (IHC). 62 pts were stratified by disease extent and early initiation of ADT, and randomized. 60 pts initiated therapy (Arm A: 20; Arm B: 40). Neutropenia was the most common G3/4 AE (Arm A: 0% Arm B: 33%). 80% of pts (Arm A: 16/20, Arm B: 32/40; p = 0.87) on both arms met primary PSA endpoint (≤4ng/mL at 28 weeks). PSA undetectable rate at 28 weeks was Arm A: 50% (10/20) and Arm B: 43% (17/40; p = 0.5). Measurable disease RR: Arm A: 78% and Arm B: 74%. 12-month biochemical PFS was Arm A 69% (95%CI: 43-85%), Arm B 74% (95%CI: 56-85%). Clinical PFS is not mature and correlative biomarker studies are ongoing. Conclusions: Co-targeting of AR signaling and cell cycle in a tissue biomarker preselected trial is feasible in mHSPC. RB loss was rare in this population. PSA RR at 28 weeks was not impacted by addition of palbociclib to ADT. Important clinical PFS data will be reported when mature. Clinical trial information: NCT02059213.
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McSorley, Stephen Thomas, Bo Khor, Paul G. Horgan, and Donald C. McMillan. "The relationship between systemic inflammation and postoperative outcomes following neoadjuvant chemoradiotherapy for rectal cancer." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): 682. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.682.
Повний текст джерелаАнотація:
682 Background: The magnitude of the systemic inflammatory response before and after surgery for rectal cancer is increasingly understood to have an impact on clinical outcomes. The aim of the present study was to examine the impact of neoadjuvant chemoradiotherapy (nCRT) on pre- and postoperative systemic inflammation and clinical outcomes in patients undergoing surgery for rectal cancer. Methods: Data was recorded prospectively for patients who underwent elective, potentially curative surgery for rectal cancer, from 2008 to 2015 at a single centre, n = 251. Patients had routine pre- and postoperative blood sampling. Results: Of the 251 patients, the majority were male (62%) and over 65 years old (57%) with node negative disease (66%). 85 patients (33%) were allocated to preoperative nCRT based on probable margin threatening disease at preoperative MRI. nCRT was significantly associated with a higher proportion of patients having neutrophil lymphocyte ratio (NLR) > 5 (39% vs. 12%, p < 0.001), and a modified Glasgow Prognostic Score (mGPS) of 2 (14% vs. 6%, p = 0.035) prior to surgery. There was no significant association between nCRT and the magnitude of the postoperative systemic inflammatory response or complications. Of the 85 patients who underwent nCRT, there was a small but significant reduction in CRP following treatment (3.25 mg/L vs. 4.1 mg/L, p = 0.007). Of the 16 patients who were systemically inflamed prior to nCRT, 9 patients achieved mGPS score 0 after treatment (p = 0.004). There was a significant association between having an mGPS score 1 or 2 both before and after nCRT and breaching established thresholds of CRP on postoperative days 2 (190mg/L, 86% vs. 33%, p = 0.002), 3 (170mg/L, 86% vs. 38%, p = 0.015) and 4 (145mg/L, 71% vs. 36%, p = 0.031). Conclusions: Allocation to nCRT was significantly associated with a systemic inflammatory response prior to surgery for rectal cancer. nCRT was significantly associated with attenuation of existing systemic inflammation. Such attenuation of the systemic inflammatory response may in part explain the efficacy of nCRT in patients with rectal cancer.
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Bazdyrev, Evgeniy D., Nadezhda A. Kalichenko, Ol’ga M. Polikutina, Yuliya S. Slepynina, and Ol’ga L. Barbarash. "Results of 1-year follow-up of patients with comorbidity of coronary artery disease and respiratory disease underwent scheduled myocardial revascularization." Russian Pulmonology 29, no. 2 (July 1, 2019): 189–98. http://dx.doi.org/10.18093/0869-0189-2019-29-2-189-198.
Повний текст джерелаАнотація:
The first goal of this study was to analyze a relationship between 1-year outcomes and respiratory comorbidity in patients with coronary artery disease (CAD) underwent scheduled coronary artery bypass grafting (CABG); the second goal of the study was to determine the most significant predictors of fatal outcome in these patients. Methods. The study involved 251 patients underwent CABG. They were stratified according to having comorbid chronic obstructive (n = 62; 24.7%) or non-obstructive lung disease (n = 65; 25.9%) or not having chronic respiratory disease (n = 124; 49.4%). Cardiovascular events during 1 year were registered. Results. An expected decrease in functional classes of CAD and chronic heart failure (CHF) was noted over 1 year. Number of non-fatal significant cardiovascular events didn’t differ in patients with or without chronic obstructive pulmonary disease (COPD). Seven patients (2.78%) died during the year; the cause of death was cardiovascular disease in all cases. Factors predicting poor outcomes included age, occupational exposure to chemicals > 3 years, incomplete myocardial revascularization, FEV1/FVC ratio, and left ventricular ejection fraction < 40%. Conclusion. COPD is a predictor of poor outcome of myocardial revascularization in patients with CAD.
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Zhu, Hui, Xuejing Yang, Jiali Li, Yanjie Ren, Tianyu Zhang, Chunze Zhang, Jintai Zhang, Jing Li, and Yan Pang. "Immune Response, Safety, and Survival and Quality of Life Outcomes for Advanced Colorectal Cancer Patients Treated with Dendritic Cell Vaccine and Cytokine-Induced Killer Cell Therapy." BioMed Research International 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/603871.
Повний текст джерелаАнотація:
Purpose.To determine the immune response after dendritic cell (DC) vaccine and cytokine-induced killer cells (CIK) therapy and assess its associated toxicity, survival benefit, and changes in the quality of life (QOL) of advanced colorectal cancer (CRC) patients.Methods.We recruited 100 patients with unresectable CRC orrelapsed CRC after surgery who received DC vaccine and CIK cells (group immunotherapy, group I), and, as a control, 251 patients who had similar characteristics and underwent similar treatments, except for this immunotherapy (group nonimmunotherapy, group NI). After a follow-up period of 489.2 ± 160.4 days, overall survival (OS) of the two groups was compared using the Kaplan-Meier method.Results.In group I, 62% of patients developed a positive delayed type hypersensitivity response, and most patients showed an improvement in physical strength (75.2%), appetite (74.2%), sleeping (72.1%), and body weight (70.1%). Adverse events were fever (29.5%), insomnia (19.2%), anorexia (9.1%), sore joints (5.4%), and skin rash (1.0%). No toxicity was observed in patients treated with DC vaccine and CIK therapy. OS was significantly longer in group I than in group NI (P= 0.043).Conclusion.DC vaccine and CIK therapy were safe and could induce an immune response against CRC, thereby improving QOL and prolonging OS.
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Mostafa-Hedeab, Gomaa, Alaa Abdelhamed Mohamed, Gamal Thabet, Dina Sabry, Randa Fayez Salam, and Manal Ewaiss Hassen. "Effect of MATE 1, MATE 2 and OCT1 Single Nucleotide Polymorphisms on Metformin Action in Recently Diagnosed Egyptian Type-2 Diabetic Patients." Biomedical and Pharmacology Journal 11, no. 1 (March 25, 2018): 149–57. http://dx.doi.org/10.13005/bpj/1356.
Повний текст джерелаАнотація:
Objective: to study the effect of MATE 1, MATE 2 and OCT1 genetic variants on metformin action in recently diagnosed Egyptian Type-2 diabetic patients. Patients & Methods: One hundred type-2 DM patients and forty healthy control were included in the study. All patients were recently diagnosed receiving no treatment before participation in the study. Three single nucleotide polymorphisms (SNPs) were Genotyped using real time PCR, Sequence Detection System: MATE1 (rs2252281), OCT1 coding variants (rs12208357) (SLC22A1) and MATE2 (rs12943590). Results: there is a significant differences between control and patients regarding MATE2 (p<0.05), OCT1 (P<0.005) distribution; in which GG (54%), CC (62%) is the most prevalent among studied patients respectively. MATE1 SNP; Patients with CC alleles and TT allele had better HBA1C (8.577±.2924), (8.7±.25) compared to CT allele patients (9.584±.3023) (P= .04) (P=.019) respectively. OCT1 SNP; CG allele patients showed better RBS (251±9.565) compared to CC allele (294.42±8.476) (p=0.004). Logistic regression test showed that RBS (p=.00001), ALT (p=.0001) and TLC (p=.025) are independent factors affecting blood glucose. Conclusion: MATE1 and OCT1 SNPs may have a potential role in metformin efficacy.
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Kushner, Erich J., Brian R. Weil, Owen J. MacEneaney, Richard G. Morgan, Michael L. Mestek, Gary P. Van Guilder, Kyle J. Diehl, Brian L. Stauffer, and Christopher A. DeSouza. "Human aging and CD31+T-cell number, migration, apoptotic susceptibility, and telomere length." Journal of Applied Physiology 109, no. 6 (December 2010): 1756–61. http://dx.doi.org/10.1152/japplphysiol.00601.2010.
Повний текст джерелаАнотація:
CD31+T cells, or so-called “angiogenic T cells,” have been shown to demonstrate vasculoprotective and neovasculogenic qualities. The influence of age on CD31+T-cell number and function is unclear. We tested the hypothesis that circulating CD31+T-cell number and migratory capacity are reduced, apoptotic susceptibility is heightened, and telomere length is shortened with advancing age in adult humans. Thirty-six healthy, sedentary men were studied: 12 young (25 ± 1 yr), 12 middle aged (46 ± 1 yr), and 12 older (64 ± 2 yr). CD31+T cells were isolated from peripheral blood samples by magnetic-activated cell sorting. The number of circulating CD31+T cells (fluorescence-activated cell sorting analysis) was lower ( P < 0.01) in older (24% of CD3+cells) compared with middle-aged (38% of CD3+cells) and young (40% of CD3+cells) men. Migration (Boyden chamber) to both VEGF and stromal cell-derived factor-1α was markedly blunted ( P < 0.05) in cells harvested from middle-aged [306.1 ± 45 and 305.6 ± 46 arbitrary units (AU), respectively] and older (231 ± 65 and 235 ± 62 AU, respectively) compared with young (525 ± 60 and 570 ± 62 AU, respectively) men. CD31+T cells from middle-aged and older men demonstrated greater apoptotic susceptibility, as staurosporine-stimulated intracellular caspase-3 activation was ∼40% higher ( P < 0.05) than young. There was a progressive age-related decline in CD31+T-cell telomere length (young: 10,706 ± 220 bp; middle-aged: 10,179 ± 251 bp; and older: 9,324 ± 192 bp). Numerical and functional impairments in this unique T-cell subpopulation may contribute to diminished angiogenic potential and greater cardiovascular risk with advancing age.
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Bacorro, Warren Ramos, Jocelyn C. Que, Teresa Tan Sy Ortin, Thomas W. Feeley, and Cielito C. Reyes-Gibby. "A cross-sectional analysis of symptom burden among adult cancer patients in a Filipino tertiary care cancer center." Journal of Clinical Oncology 33, no. 29_suppl (October 10, 2015): 98. http://dx.doi.org/10.1200/jco.2015.33.29_suppl.98.
Повний текст джерелаАнотація:
98 Background: Palliative and supportive care has been shown to improve quality of life (QOL) and survival and reduce caregiver burden and costs, but remains poorly integrated into cancer care in the Philippines. Understanding symptom burden profile among patients will guide policy-making in a limited/moderate resource setting. Methods: This cross-sectional study was conducted among adult Filipino cancer patients. Demographic and clinical data were collected from medical records and patient interviews. Symptom severity and interference were assessed using the M.D. Anderson Symptom Inventory. Symptom prevalence and mean severity scores were determined. Pearson correlation analysis was used to examine relationships between symptom severity and interference. Results: Participants (n = 251)were aged 18-80 years; the majority were aged < 60, females, or with good performance status (PS). Breast, head-and-neck and gastrointestinal primaries were most common; 45% had advanced disease. Moderate and severe symptoms were prevalent across stages. Fatigue (65%), pain (62%), sadness (62%), and anxiety/distress (58%) were the most prevalent, most severe and most interfering. In metastatic disease, sadness was most prevalent, and fatigue, most serious; among those with poor PS, disturbed sleep was most prevalent and most serious. Pain was more disabling among females, and fatigue and sadness, among the elderly. Conclusions: This is the first study to describe symptom burden among adult Filipino cancer patients. The clinical impact of symptoms is determined by their concurrence and the patient’s demographic and clinical profile. Symptom burden is highest for fatigue, pain, sadness, and anxiety/distress. Comprehensive symptom evaluation and tailored approach to care is necessary for optimal management. While a clinical practice guideline (CPG) has been adopted for use at our institute, effective CPGs for the screening, assessment and management of fatigue, depression and anxiety/distress have yet to be identified and implemented.
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Brandt, Andressa Graziele, and Márcia de Souza Hobold. "Mudanças e continuidades dos marcos legais do curso de pedagogia no Brasil." Revista Internacional de Educação Superior 5 (January 15, 2019): e019027. http://dx.doi.org/10.20396/riesup.v5i0.8652576.
Повний текст джерелаАнотація:
Objetiva-se na presente pesquisa analisar os quatro marcos legais do curso de Pedagogia no Brasil, no que se refere as mudanças e continuidades acerca dos currículos para a formação de professores. Apresenta-se como questão central de pesquisa: Para atingir a proposta aqui elucidada, propusemo-nos a responder ao seguinte questionamento: Que elementos de continuidade e de mudança estão expressos nos quatro marcos legais do curso de Pedagogia no Brasil? É uma pesquisa de abordagem qualitativa, com desenvolvimento de análise documental da legislação do curso de Pedagogia, por meio da técnica a análise de conteúdo para a obtenção/elaboração das análises propostas. Os autores basilares dessa pesquisa são Bissolli da Silva (2010) e Scheibe (2003). Os resultados parciais mostraram os quatro marcos legais que constituíram os currículos dos cursos de Pedagogia ao longo de sua constituição histórica, são: 1) Decreto-lei nº 1190/1939; 2) Parecer nº 251/62; 3) Parecer nº 252/69; e Resolução CFE nº 2/69; e 4) Parecer CNE/CP nº 5/2005; e Resolução CNE/CP nº 1/2006. Constatou-se que os quatro marcos legais apresentam elementos de mudança e continuidade que influenciaram diretamente a constituição histórica dos currículos de formação de professores no país.
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Xu, Yaying, Changqing Zhu, Changjie Xu, Jun Sun, Donald Grierson, Bo Zhang, and Kunsong Chen. "Integration of Metabolite Profiling and Transcriptome Analysis Reveals Genes Related to Volatile Terpenoid Metabolism in Finger Citron (C. medica var. sarcodactylis)." Molecules 24, no. 14 (July 15, 2019): 2564. http://dx.doi.org/10.3390/molecules24142564.
Повний текст джерелаАнотація:
Finger citron (Citrus medica var. sarcodactylis) is a popular ornamental tree and an important source of essential oils rich in terpenoids, but the mechanisms behind volatile formation are poorly understood. We investigated gene expression changes combined with volatile profiling of ten samples from three developing organs: flower, leaf, and fruit. A total of 62 volatiles were identified with limonene and γ-terpinene being the most abundant ones. Six volatiles were identified using partial least squares discriminant analysis (PLS-DA) that could be used as markers for distinguishing finger citron from other citrus species. RNA-Seq revealed 1,611,966,118 high quality clean reads that were assembled into 32,579 unigenes. From these a total of 58 terpene synthase (TPS) gene family members were identified and the spatial and temporal distribution of their transcripts was measured in developing organs. Transcript levels of transcription factor genes AP2/ERF (251), bHLH (169), bZIP (76), MYB (155), NAC (184), and WRKY (66) during finger citron development were also analyzed. From extracted subnetworks of three modules constructed by weighted gene co-expression network analysis (WGCNA), thirteen TPS genes and fifteen transcription factors were suggested to be related to volatile terpenoid formation. These results provide a framework for future investigations into the identification and regulatory network of terpenoids in finger citron.
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Rathinasabapathi, Pasupathi, Natarajan Purushothaman, and Madasamy Parani. "Genome-wide DNA polymorphisms in Kavuni, a traditional rice cultivar with nutritional and therapeutic properties." Genome 59, no. 5 (May 2016): 363–66. http://dx.doi.org/10.1139/gen-2016-0025.
Повний текст джерелаАнотація:
Although rice genome was sequenced in the year 2002, efforts in resequencing the large number of available accessions, landraces, traditional cultivars, and improved varieties of this important food crop are limited. We have initiated resequencing of the traditional cultivars from India. Kavuni is an important traditional rice cultivar from South India that attracts premium price for its nutritional and therapeutic properties. Whole-genome sequencing of Kavuni using Illumina platform and SNPs analysis using Nipponbare reference genome identified 1 150 711 SNPs of which 377 381 SNPs were located in the genic regions. Non-synonymous SNPs (62 708) were distributed in 19 251 genes, and their number varied between 1 and 115 per gene. Large-effect DNA polymorphisms (7769) were present in 3475 genes. Pathway mapping of these polymorphisms revealed the involvement of genes related to carbohydrate metabolism, translation, protein-folding, and cell death. Analysis of the starch biosynthesis related genes revealed that the granule-bound starch synthase I gene had T/G SNPs at the first intron/exon junction and a two-nucleotide combination, which were reported to favour high amylose content and low glycemic index. The present study provided a valuable genomics resource to study the rice varieties with nutritional and medicinal properties.
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Shtareva, A. V., D. S. Shtarev, I. A. Bahtiyarov, V. I. Klopov, and A. N. Ganus. "Dependence of activity of photocatalysts based on calcium bismuthates on initial concentration of the pollutant." Izvestiâ vysših učebnyh zavedenij. Priborostroenie 62, no. 3 (March 31, 2019): 251–55. http://dx.doi.org/10.17586/0021-3454-2019-62-3-251-255.
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Allsopp, N., and W. D. Stock. "Plant Protection Research Institute." Bothalia 23, no. 1 (October 10, 1993): 91–104. http://dx.doi.org/10.4102/abc.v23i1.794.
Повний текст джерелаАнотація:
A survey of the mycorrhizal status of plants growing in the Cape Floristic Region of South Africa was undertaken to assess the range of mycorrhizal types and their dominance in species characteristic of this region. Records were obtained by examining the root systems of plants growing in three Cape lowland vegetation types, viz. West Coast Strandveld, West Coast Renosterveld and Sand Plain Lowland Fynbos for mycorrhizas, as well as by collating literature records of mycorrhizas on plants growing in the region. The mycorrhizal status of 332 species is listed, of which 251 species are new records. Members of all the important families in this region have been examined. Mycorrhizal status appears to be associated mainly with taxonomic position of the species. Extrapolating from these results, we conclude that 62% of the flora of the Cape Floristic Region form vesicular-arbuscular mycorrhizas, 23% have no mycorrhizas, 8% are ericoid mycorrhizal, 2% form orchid mycorrhizas, whereas the mycorrhizal status of 4% of the flora is unknown. There were no indigenous ectomycor- rhizal species. The proportion of non-mycorrhizal species is high compared to other ecosystems. In particular, the lack of mycorrhizas in several important perennial families in the Cape Floristic Region is unusual. The diversity of nutrient acquiring adaptations, including the range of mycorrhizas and cluster roots in some non-mycorrhizal families, may promote coexistence of plants in this species-rich region.
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Moccia, Alden A., Kimberly Schaff, Ciara Freeman, Paul J. Hoskins, Richard J. Klasa, Kerry J. Savage, Tamara N. Shenkier, Randy D. Gascoyne, Joseph M. Connors, and Laurie H. Sehn. "Long-term outcomes of R-CEOP show curative potential in patients with DLBCL and a contraindication to anthracyclines." Blood Advances 5, no. 5 (March 8, 2021): 1483–89. http://dx.doi.org/10.1182/bloodadvances.2020002982.
Повний текст джерелаАнотація:
Abstract Doxorubicin plays an integral role in the treatment of patients with diffuse large B-cell lymphoma (DLBCL) but can be associated with significant toxicity. Treatment guidelines of British Columbia (BC) Cancer recommend the substitution of etoposide for doxorubicin in standard-dose R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) (R-CEOP) for patients who have a contraindication to anthracyclines; however, it is unknown if this compromises treatment outcome. We identified all patients with newly diagnosed DLBCL who were treated in BC with curative intent with R-CEOP (n = 70) within the study period. Outcome in this population was compared with a 2:1 case-matched control group (n = 140) treated with R-CHOP and matched for age, clinical stage, and International Prognostic Index score. The 10-year time to progression and disease-specific survival were not significantly different for patients treated with R-CEOP compared with patients in the R-CHOP control group (53% vs 62% [P = .089] and 58% vs 67% [P = .251], respectively). The 10-year overall survival was lower in the R-CEOP group (30% vs 49%, P = .002), reflecting the impact of underlying comorbidities and frailty of this population. R-CEOP represents a useful treatment alternative for patients with DLBCL and an absolute contraindication to the use of anthracyclines, with curative potential.
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Gordon, Richard. "Mithraic ideas and reflections - ROBERT TURCAN, RECHERCHES MITHRIAQUES: QUARANTE ANS DE QUESTIONS ET D'INVESTIGATION (Les Belles Lettres, Paris 2016). Pp. 517, 62 ills. ISBN 978-2-251-42063-9. EUR. 65." Journal of Roman Archaeology 30 (2017): 666–69. http://dx.doi.org/10.1017/s1047759400074511.
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Selwyn, Joshua Anish S., Monali B. Kadam, and Snigdha Thakur. "Effect of COVID-19 lockdown on air quality and solid waste generation: a case study in a metropolitan city, Mumbai, India." International Journal Of Community Medicine And Public Health 7, no. 11 (October 26, 2020): 4467. http://dx.doi.org/10.18203/2394-6040.ijcmph20204746.
Повний текст джерелаАнотація:
Background: There is limited information describing the change on quality of air and solid waste generation if there is limited and efficient use of vehicles and the shutdown of industries producing hazardous air pollutants that have been achieved by the lockdown. Study assessed changes in the quality of air and solid waste generation due to Lockdown.Methods: It was an analytical study where the data is received from Maharashtra Pollution Control Board data for Mumbai during the period from December 2019 to July 2020. Analysis of Air pollutants like PM10, SO2, NO2, Air quality index, and solid waste generated are taken into consideration.Results: Findings of air quality data has been analysed from December to July. Where the mean air quality index before the lockdown was 251 which is very unhealthy and during lockdown was 62 which is moderate which is a 75% reduction in the pollutants and the solid waste generation before the lockdown was 6338.63 Metric tons per day which have been reduced to 4121.23 Metric tons per day which is a reduction of 34.98 %.Conclusions: This study provides information about how the environment would heal itself if there is a restriction on the use of vehicles and shutting down factories producing hazardous pollutants. This would provide the evidence for the Pollution Control Board to implement policy to improve air quality and solid waste generation, which would have a positive impact on human health and ecosystem.
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Guiraud, Vincent, Thierry Gallarda, David Calvet, Guillaume Turc, Catherine Oppenheim, Frédéric Rouillon, and Jean-Louis Mas. "Depression predictors within six months of ischemic stroke: The DEPRESS Study." International Journal of Stroke 11, no. 5 (February 12, 2016): 519–25. http://dx.doi.org/10.1177/1747493016632257.
Повний текст джерелаАнотація:
Background Depression negatively affects rehabilitation and quality of life after stroke. Identifying in the acute phase patients at high risk for post-stroke depression would facilitate early detection of depressive symptoms. Methods The DEPRESS (Depression Predictors after Ischemic Stroke) study was a prospective cohort study designed to identify baseline predictors of depression occurring within six months after ischemic stroke and high-risk patients for post-stroke depression. All patients without aphasia were screened for depression by a neurologist using the Patient Health Questionnaire, and the diagnosis was confirmed by a psychiatrist with the Mini International Neuropsychiatric Interview. In severely aphasic patients, depression was diagnosed using the Aphasic Depression Rating Scale and the Visual Analog Mood Scale. Results Depression was present in 61 of 251 (24%) patients enrolled in the DEPRESS study. Female gender, prior history of depression, major physical disability, prior history of stroke, stressful life event exposure in the month preceding stroke onset, and pathologic crying were significant predictors of depression within six months after ischemic stroke. Depression was more frequent in patients with left caudate and/or lenticular nucleus lesion (OR = 2.4, 95% confidence interval, 0.97–5.91), but the difference was not significant. The presence of ≥2 predictors identified the largest proportion of depressed patients (62%) in the smallest proportion of the cohort (36%). Conclusion Female gender, prior history of depression, major physical disability, prior history of stroke, recent stressful life event exposure before stroke, and pathologic crying were significant predictors of post-stroke depression occurring within six months after stroke onset.
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Palmisciano, Paolo, Ali S. Haider, Mohammadmahdi Sabahi, Chibueze D. Nwagwu, Othman Bin Alamer, Gianluca Scalia, Giuseppe E. Umana, et al. "Primary Skull Base Chondrosarcomas: A Systematic Review." Cancers 13, no. 23 (November 26, 2021): 5960. http://dx.doi.org/10.3390/cancers13235960.
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Background: Primary skull base chondrosarcomas (SBCs) can severely affect patients’ quality of life. Surgical-resection and radiotherapy are feasible but may cause debilitating complications. We systematically reviewed the literature on primary SBCs. Methods: PubMed, EMBASE, Scopus, Web-of-Science, and Cochrane were searched following the PRISMA guidelines to include studies of patients with primary SBCs. Clinical characteristics, management strategies, and treatment outcomes were analyzed. Results: We included 33 studies comprising 1307 patients. Primary SBCs mostly involved the middle-fossa (72.7%), infiltrating the cavernous-sinus in 42.4% of patients. Cranial-neuropathies were reported in 810 patients (62%). Surgical-resection (93.3%) was preferred over biopsy (6.6%). The most frequent open surgical approaches were frontotemporal-orbitozygomatic (17.6%) and pterional (11.9%), and 111 patients (21.3%) underwent endoscopic-endonasal resection. Post-surgical cerebrospinal-fluid leaks occurred in 36 patients (6.5%). Radiotherapy was delivered in 1018 patients (77.9%): photon-based (41.4%), proton-based (64.2%), and carbon-based (13.1%). Severe post-radiotherapy complications, mostly hypopituitarism (15.4%) and hearing loss (7.1%) were experienced by 251 patients (30.7%). Post-treatment symptom-improvement (46.7%) and reduced/stable tumor volumes (85.4%) showed no differences based on radiotherapy-protocols (p = 0.165; p = 0.062). Median follow-up was 67-months (range, 0.1–376). SBCs recurrences were reported in 211 cases (16.1%). The 5-year and 10-year progression-free survival rates were 84.3% and 67.4%, and overall survival rates were 94% and 84%. Conclusion: Surgical-resection and radiotherapy are effective treatments in primary SBCs, with acceptable complication rates and favorable local tumor control.
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Urbonavičienė, Dalia, Česlovas Bobinas, Ramunė Bobinaitė, Lina Raudonė, Sonata Trumbeckaitė, Jonas Viškelis, and Pranas Viškelis. "Composition and Antioxidant Activity, Supercritical Carbon Dioxide Extraction Extracts, and Residue after Extraction of Biologically Active Compounds from Freeze-Dried Tomato Matrix." Processes 9, no. 3 (March 5, 2021): 467. http://dx.doi.org/10.3390/pr9030467.
Повний текст джерелаАнотація:
Supercritical carbon dioxide extraction (SCE-CO2) is an attractive, green technology that is used for the recovery of biologically active compounds from plant material. The antioxidant potential of lipophilic fractions (extract obtained with SCE-CO2) and hydrophilic fractions (extracts obtained from the residue after extraction) obtained from a matrix of freeze-dried tomatoes (cvs. “Admiro” F1, “Jurgiai”, “Vilina”, “Pirmutis”, and “Skariai”) was assessed via different antioxidant activity methods. The total amount of polyphenols, carotenoids, and carotenoid isomers before and after SCE-CO2 extraction was also determined. To investigate the effect of the SCE-CO2 extract on the viability of cancer cells, rat glioblastoma C6 cells were chosen. The SCE-CO2 yielded an average of 800 mg of lipophilic fraction per 100 g of freeze-dried tomatoes. The ABTS•+ scavenging activity of the extract was 251 ± 3.4 µmol TE/g. After SCE-CO2 extraction, the DPPH•-RSA of the freeze-dried tomato matrix was 7 to 12% higher. There was a strong positive correlation (R = 0.84) between the total polyphenolics content and the DPPH•-RSA of the tomato samples. The SCE-CO2 increased the radical scavenging activity of the extraction residue, indicating that a considerable fraction of the hydrophilic compounds with particular antioxidant capacity remain unextracted from the tomato matrix. Our results reveal the cytotoxic effect of lycopene extract rich in cis-isomers (62% cis-isomers of the total lycopene content) on rat glioblastoma C6 cells. The viability of the glioblastoma C6 cells significantly decreased (−42%) at a total lycopene concentration of 2.4 µM after 24 h of incubation.
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Lachant, Daniel, Allison Light, Kevin Hannon, Farrukh Abbas, Michael Lachant, and R. James White. "Comparison of chest- and wrist-based actigraphy in pulmonary arterial hypertension." European Heart Journal - Digital Health 3, no. 1 (November 2, 2021): 90–97. http://dx.doi.org/10.1093/ehjdh/ztab095.
Повний текст джерелаАнотація:
Abstract Aims Activity trackers for clinical trials and remote monitoring are appealing as they provide objective data outside of the clinic setting. Algorithms determine physical activity intensity and count steps. Multiple studies show physical inactivity in pulmonary arterial hypertension (PAH). There are no studies comparing different activity trackers worn on different parts of the body in PAH. We had patients with PAH simultaneously wear two different accelerometers, compared measures between the two devices, and correlated the measures with standard clinical metrics in PAH. Methods and results This was a single-centre, prospective observational study. Daily physical activity and daily total steps were measured using Actigraph GT9X Link and MC10 Biostamp nPoint for 5–10 days. Actigraph was worn on the non-dominant hand and the MC10 Biostamp nPoint was worn on the chest and leg with disposable adhesives. Twenty-two participants wore both accelerometers >12 h/day for an average 7.8 days. The average activity time measured by Actigraph was significantly higher than that measured by MC10 (251 ± 25 min vs. 113 ± 18 min, P = 0.0001). Actigraph’s algorithm reported more time in light activity than moderate (190 ± 62 min vs. 60 ± 56 min, P = 0.0001). REVEAL 2.0 scores correlated highly with activity time measured using either device. Invasively measured haemodynamics within 7 days did not correlate with activity time or daily steps. Conclusion Different activity trackers yield discordant results in PAH patients. Further studies are needed in determining the best device, optimal wear time, and different thresholds for activities in chronic diseases.
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SUNER KEKLIK, Sinem, and Ayse NUMANOLU AKBAS. "Effects of Covid-19 pandemic in Turkey: Physical activity, smartphone usage, musculoskeletal system." Journal of Experimental and Clinical Medicine 38, no. 4 (August 30, 2021): 550–56. http://dx.doi.org/10.52142/omujecm.38.4.28.
Повний текст джерелаАнотація:
This study aims to evaluate relationship between physical activity level, smartphone usage, back and neck health during Covid-19 pandemic. Participants between ages of 18-65 were included in study. Smartphone usage was evaluated with Smartphone Addiction Scale-Short Version, physical activity levels with short form of International Physical Activity Questionnaire. Oswestry Disability Index and Neck Bournemouth Questionnaire was used to evaluate back and neck problems. A total of 251 people (179 women, 72 men, age: 28.11±9.49 years, min-max: 18-62 years) participated in study. 134 participants (53.38%) had low physical activity levels; 35 individuals (13.94%) had sufficient physical activity levels while 82 participants (32.66%) were not physically active. A weak positive correlation was found between neck pain and total score of smartphone addiction scale, daily smartphone usage time, daily smartphone check frequency, and first check time after waking up (r=0.199, r=0.149, r=0.132, respectively). A weak negative correlation was found between neck pain and first check time after waking up (r=-0.145). As a result of study, it was observed that physical activity levels were insufficient in majority of individuals who participated in survey. The relationships we expected between physical activity level, smartphone usage characteristics, low back and neck health could not be demonstrated, only weak relationships were found between some features of smartphone use and neck health. We believe that finding solutions to increase physical activity levels of individuals during pandemic period will have both protective effects on health and will prevent problems by affecting musculoskeletal system positively.
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Raut, Bharat, Abhinav Vaidya, Jessen Gurung, Subhash Acharya, Pravesh Basnet, H. S. Sodhi, Dambar Bahadur Karki, and Sunil Chandra Jha. "Gender Difference in the Coronary Risk Factors Amongst the Patients with Acute Coronary Events in Nepal." Nepalese Heart Journal 2, no. 2 (December 18, 2019): 7–12. http://dx.doi.org/10.3126/njh.v2i2.26032.
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Background: Acute Coronary Event (ACE) is the commonest cause of admission in Coronary Care Unit (CCU) in Nepal. With growing epidemic of coronary artery disease in Asian countries, there is an urgent need to assess the locally prevalent coronary risk factors. There seems to be a significant difference in the risk factors amongst male and female population.
Methods: A prospective analysis was done in 404 consecutive patients admitted with an acute coronary event in CCU in the Norvic Escorts Health Care And Research Centre, Kathmandu from January 1999 to July 2002. The data was analyzed and various risk factors were stratified.
Results: Out of 404 patients of ACE, 251 (62%) patients were males and 153 (38%) patients were females. The commonest risk factors amongst male patients were smoking in 160 (64%), hypertension in 148 (59%) and dyslipidemia in 133(53%), followed by diabetes in 80 (32%) and a positive family history in 65 (26%) patients. As against this, female patients had commonest risk factors as hypertension in 71 (47%), diabetes in 71 (47%) and smoking in 64 (42%), followed by a positive family history in 47 (31%), and dyslipidemia in 23 (15%) patients.
Conclusions: Smoking is the most common risk factor followed by Hypertension and Dyslipidemia in male patients with ACE, but most female patients with ACE have Hypertension as the most common coronary risk factor followed by diabetes mellitus. This may be partly due to the difference of socio-economic status of two genders in Nepal. An aggressive preventive approach is mandatory to decrease the expensive burden of coronary artery disease in this poor Himalayan country.
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Vardy, J. L., C. Booth, G. R. Pond, H. Zhang, J. Galica, H. Dhillon, S. J. Clarke, and I. F. Tannock. "Cytokine levels in patients (pts) with colorectal cancer and breast cancer and their relationship to fatigue and cognitive function." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 9070. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.9070.
Повний текст джерелаАнотація:
9070 Background: Cytokines have been associated with fatigue and cognitive dysfunction. Here we evaluated plasma cytokine levels in pts with colorectal cancer (CRC) and breast cancer (BC) who were free of evident disease, and in healthy volunteers. Methods: Serum levels of 10 cytokines were measured using a LiquiChip assay on 251 subjects. CRC pts (n=136, ages 23–75) were evaluated at baseline (mean 8 weeks post-surgery [n=107] or before surgery [n=29]), with repeat measures at 6 months (56 post chemotherapy [CT], 14 without CT) and 12 months (32 post CT, 7 without CT). BC pts (n=51, ages 29–60) were within 5 years of diagnosis (33 after adjuvant CT). Healthy volunteers (n=64) had ages 20–62. Cancer pts completed questionnaires for fatigue & QOL (FACT-F), anxiety/depression (GHQ), and perceived cognitive function (FACT-COG); they had neuropsychological assessment. Results: Cytokines were elevated in all cancer groups compared to healthy controls (p-values <0.001; selected data in table ). Values were highest after surgery but remained significantly higher than healthy controls at 6–60 months after diagnosis, with a trend to being higher in cancer patients who had not received CT. There was a trend to elevated cytokines being associated with greater fatigue and cognitive impairment in both CRC and BC, but no association with QOL or anxiety & depression. Conclusions: Cytokine levels were elevated in all cancer groups compared to healthy volunteers and remained elevated up to 5 years post diagnosis; they may be associated with cognitive dysfunction and fatigue. [Table: see text] No significant financial relationships to disclose.
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Victoria, Stere, Tarcea Monica, and Ruta Florina. "Assesing the Knowledge, Attitudes and Eating Habits of Dietary Fibers in Tîrgu-Mureş Population." Acta Medica Marisiensis 61, no. 2 (June 1, 2015): 128–31. http://dx.doi.org/10.1515/amma-2015-0037.
Повний текст джерелаАнотація:
Abstract Background: The aim of the study was to assess the knowledge, attitudes and eating habits upon consumption of dietary fibers in a group of people from Tirgu-Mures area. Material and Method: We used a transversal descriptive study conducted on a group of 251 subjects from the urban area (76.4%), as well as from the rural area (23.6%), aged between 18 and 62 years, obtained using an online questionnaire consisting of 40 questions related to knowledge and attitude towards dietary fibers and estimated consumption of fiber from whole foods. Results: In the study group, we observed that 21.28% consumed whole cereals once per week and 18% did not consume cereals at all; regarding fruit consumption 17.44% consumed 6-8 pieces/week, and 3.4% consumed over 18 pieces/week. Frequency of fast food –meals consuming: 67.68% did not consume fast-food meals, 25.25% ate fast food once/week, and 1.1% consumed fast food between 8-10 times/week. Concerning the statement that fibers can prevent and/or treat colon cancer and obesity, 40% fully accepted the statement, 40% agreed, 14.29% were indifferent and 4.7% were against. From the total group of subjects, approximately 37.6% knew the meaning and classification of dietary fiber, 26.8% knew the recommended amount of fiber to be consumed daily, and 5.9% did not check the fiber content of foods ever. Conclusions: The inclusion of cereals and whole foods in diet is recommended in all nutrition guidelines worldwide, because of their association with a high health status, and prevention of chronic diseases. Consumers need to understand the benefits of whole foods, also to recognize and read the information about it on food labels.
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Meinilä, Jelena, Anita Valkama, Saila B. Koivusalo, Beata Stach-Lempinen, Kristiina Rönö, Jaana Lindström, Hannu Kautiainen, Johan G. Eriksson, and Maijaliisa Erkkola. "Is improvement in the Healthy Food Intake Index (HFII) related to a lower risk for gestational diabetes?" British Journal of Nutrition 117, no. 8 (April 28, 2017): 1103–9. http://dx.doi.org/10.1017/s0007114517001015.
Повний текст джерелаАнотація:
AbstractThe aim was to analyse whether changes in the Healthy Food Intake Index (HFII) during pregnancy are related to gestational diabetes (GDM) risk. The 251 pregnant women participating had a pre-pregnancy BMI≥30 kg/m2 and/or a history of GDM. A 75 g oral glucose tolerance test (OGTT) was performed during the first and second trimesters of pregnancy for assessment of GDM. A normal OGTT result at first trimester was an inclusion criterion for the study. FFQ collected at first and second trimesters served for calculating the HFII. A higher HFII score reflects higher adherence to the Nordic Nutrition Recommendations (NNR) (score range 0–17). Statistical methods included Student’s t test, Mann–Whitney U test, Fisher’s exact test and linear and logistic regression analyses. The mean HFII at first trimester was 10·1 (95 % CI 9·7, 10·4) points, and the mean change from the first to the second trimester was 0·35 (95 % CI 0·09, 0·62) points. The range of the HFII changes varied from –7 to 7. The odds for GDM decreased with higher HFII change (adjusted OR 0·83 per one unit increase in HFII; 95 % CI 0·69, 0·99; P=0·043). In the analysis of the association between HFII-sub-indices and GDM, odds for GDM decreased with higher HFII-Fat change (fat percentage of milk and cheese, type of spread and cooking fats) but it was not significant in a fully adjusted model (P=0·058). Dietary changes towards the NNR during pregnancy seem to be related to a lower risk for GDM.
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Moraes, Pedro Ivo M., Claudia Rodrigues Alves, Marco Tulio Souza, Suzi Emiko Kawakami, Iran Goncalves Jr, Adriano Henrique Pereira Barbosa, Antonio Celio Moreno, Adriano Mendes Caixeta, and Antonio Carlos Carvalho. "Cardiogenic shock after ST elevation myocardial infarction and IABP-SHOCK II risk score validation in a cohort treated with pharmacoinvasive strategy." Open Heart 6, no. 2 (July 2019): e001069. http://dx.doi.org/10.1136/openhrt-2019-001069.
Повний текст джерелаАнотація:
ObjectiveTo validate the Intra-aortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) score in patients with cardiogenic shock after ST elevation myocardial infarction (STEMI) treated with pharmacoinvasive strategy (PhIS) and to analyse the influence of ischaemia time on different risk strata.MethodsWe analysed 2143 patients with STEMI who underwent reperfusion with tenecteplase in primary health services between May 2010 and April 2017 and were transferred to a tertiary hospital for cardiac catheterisation and continuity of care. Those who evolved to cardiogenic shock were scored as low (0–2), moderate (3–4) or high (5–9) risk of death in 30 days and pairwise-log-rank test was used to compare strata. Time intervals between symptoms onset and lytic (pain-to-needle) and fibrinolytic-catheterisation were also compared.ResultsCardiogenic shock occurred in 212 (9.9%) individuals. The 30-day mortality using the IABP-SHOCK II score was 26.6% for low-risk (n=94), 53.2% for moderate-risk (n=62) and 76% for high-risk (n=25) analysed patients (p<0.001). Validation of the score showed good discrimination for death, area under the curve of 0.73 (CI: 0.66 to 0.81; p<0.001). The median intervals of pain-to-needle and fibrinolytic-catheterisation showed no association with the group stratification (220 vs 251 vs 200 min; p=0.22 and 390 vs 435 vs 315 min; p=0.18, respectively).ConclusionsIn patients with cardiogenic shock after STEMI treated with PhIS, risk stratification using IABP-SHOCK II score was adequate. There was no influence of pain-to-needle and fibrinolytic-catheterisation times on the ability to the score model stratification.
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Cardinale, Daniela, Alessandro Colombo, Rosalba Torrisi, Maria T. Sandri, Maurizio Civelli, Michela Salvatici, Giuseppina Lamantia, et al. "Trastuzumab-Induced Cardiotoxicity: Clinical and Prognostic Implications of Troponin I Evaluation." Journal of Clinical Oncology 28, no. 25 (September 1, 2010): 3910–16. http://dx.doi.org/10.1200/jco.2009.27.3615.
Повний текст джерелаАнотація:
Purpose Treatment of breast cancer with trastuzumab is complicated by cardiotoxicity in up to 34% of the patients. In most patients, trastuzumab-induced cardiotoxicity (TIC) is reversible: left ventricular ejection fraction (LVEF) improves after trastuzumab withdrawal and with, or sometimes without, initiation of heart failure (HF) therapy. The reversibility of TIC, however, is not foreseeable, and identification of patients at risk and of those who will not recover from cardiac dysfunction is crucial. The usefulness of troponin I (TNI) in the identification of patients at risk for TIC and in the prediction of LVEF recovery has never been investigated. Patients and Methods In total, 251 women were enrolled. TNI was measured before and after each trastuzumab cycle. LVEF was evaluated at baseline, every 3 months during trastuzumab therapy, and every 6 months afterward. In case of TIC, trastuzumab was discontinued, and HF treatment with enalapril and carvedilol was initiated. TIC was defined as LVEF decrease of > 10 units and below 50%. Recovery from TIC was defined as LVEF increase above 50%. Results TIC occurred in 42 patients (17%) and was more frequent in patients with TNI elevation (TNI+; 62% v 5%; P < .001). Twenty-five patients (60%) recovered from TIC. LVEF recovery occurred less frequently in TNI+ patients (35% v 100%; P < .001). At multivariate analysis, TNI+ was the only independent predictor of TIC (hazard ratio [HR], 22.9; 95% CI, 11.6 to 45.5; P < .001) and of lack of LVEF recovery (HR, 2.88; 95% CI,1.78 to 4.65; P < .001). Conclusion TNI+ identifies trastuzumab-treated patients who are at risk for cardiotoxicity and are unlikely to recover from cardiac dysfunction despite HF therapy.
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Kurstjens, Steef, Jeroen H. F. de Baaij, Hacene Bouras, René J. M. Bindels, Cees J. J. Tack, and Joost G. J. Hoenderop. "Determinants of hypomagnesemia in patients with type 2 diabetes mellitus." European Journal of Endocrinology 176, no. 1 (January 2017): 11–19. http://dx.doi.org/10.1530/eje-16-0517.
Повний текст джерелаАнотація:
Background Hypomagnesemia (plasma magnesium (Mg2+) concentration <0.7 mmol/L) has been described in patients with type 2 diabetes. Polypharmacy is inevitable when treating a complex disease such as type 2 diabetes and could explain disturbances in the plasma Mg2+ concentration. In this study, we aimed to establish the extent of hypomagnesemia in a cohort of type 2 diabetes patients and to identify the determinants of plasma Mg2+ levels. Methods Patient data and samples of 395 type 2 diabetes patients were investigated. Plasma Mg2+ concentrations were measured using a spectrophotometric assay. Using Pearson correlation analyses, variables were correlated to plasma Mg2+ levels. After excluding confounding variables, all parameters correlating (P < 0.1) with plasma Mg2+ were included in a stepwise backward regression model. Results The mean plasma Mg2+ concentration in this cohort was 0.74 ± 0.10 mmol/L. In total, 121 patients (30.6%) suffered from hypomagnesemia. Both plasma triglyceride (r = −0.273, P < 0.001) and actual glucose levels (r = −0.231, P < 0.001) negatively correlated with the plasma Mg2+ concentration. Patients using metformin (n = 251, 62%), proton pump inhibitors (n = 179, 45%) or β-adrenergic receptor agonists (n = 31, 8%) displayed reduced plasma Mg2+ levels. Insulin use (n = 299, 76%) positively correlated with plasma Mg2+ levels. The model predicted (R2) 20% of all variance in the plasma Mg2+ concentration. Conclusions Hypomagnesemia is highly prevalent in type 2 diabetes patients. Plasma triglycerides and glucose levels are major determinants of the plasma Mg2+ concentration, whereas only a minor part (<10%) of hypomagnesemia can be explained by drug intake, excluding polypharmacy as a major cause for hypomagnesemia in type 2 diabetes.
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Wade, D. T., P. M. Makela, H. House, C. Bateman, and P. Robson. "Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis." Multiple Sclerosis Journal 12, no. 5 (September 2006): 639–45. http://dx.doi.org/10.1177/1352458505070618.
Повний текст джерелаАнотація:
The object of this study was to monitor the safety and efficacy of long-term use of an oromucosal cannabis-based medicine (CBM) in patients with multiple sclerosis (MS). A total of 137 MS patients with symptoms not controlled satisfactorily using standard drugs entered this open-label trial following a 10-week, placebo-controlled study. Patients were assessed every eight weeks using visual analogue scales and diary scores of main symptoms, and were followed for an average of 434 days (range: 21- 814). A total of 58 patients (42.3%) withdrew due to lack of efficacy (24); adverse events (17); withdrew consent (6); lost to follow-up (3); and other (8). Patients reported 292 unwanted effects, of which 251 (86%) were mild to moderate, including oral pain (28), dizziness (20), diarrhoea (17), nausea (15) and oromucosal disorder (12). Three patients had five ‘serious adverse events’ between them - two seizures, one fall, one aspiration pneumonia, one gastroenteritis. Four patients had first-ever seizures. The improvements recorded and dosage taken in the acute study remained stable. Planned, sudden interruption of CBM for two weeks in 25 patients (of 62 approached) did not cause a consistent withdrawal syndrome, although 11 (46%) patients reported at least one of - tiredness, interrupted sleep, hot and cold flushes, mood alteration, reduced appetite, emotional lability, intoxication or vivid dreams. Twenty-two (88%) patients re-started CBM treatment. We conclude that long-term use of an oromucosal CBM (Sativex) maintains its effect in those patients who perceive initial benefit. The precise nature and rate of risks with long-term use, especially epilepsy, will require larger and longer-term studies.
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Indseth, Thor, Mari Grøsland, Trude Arnesen, Katrine Skyrud, Hilde Kløvstad, Veneti Lamprini, Kjetil Telle, and Marte Kjøllesdal. "COVID-19 among immigrants in Norway, notified infections, related hospitalizations and associated mortality: A register-based study." Scandinavian Journal of Public Health 49, no. 1 (January 7, 2021): 48–56. http://dx.doi.org/10.1177/1403494820984026.
Повний текст джерелаАнотація:
Aim: Research concerning COVID-19 among immigrants is limited. We present epidemiological data for all notified cases of COVID-19 among the 17 largest immigrant groups in Norway, and related hospitalizations and mortality. Methods: We used data on all notified COVID-19 cases in Norway up to 18 October 2020, and associated hospitalizations and mortality, from the emergency preparedness register (including Norwegian Surveillance System for Communicable Diseases) set up by The Norwegian Institute of Public Health to handle the pandemic. We report numbers and rates per 100,000 people for notified COVID-19 cases, and related hospitalizations and mortality in the 17 largest immigrant groups in Norway, crude and with age adjustment. Results: The notification, hospitalization and mortality rates per 100,000 were 251, 21 and five, respectively, for non-immigrants; 567, 62 and four among immigrants; 408, 27 and two, respectively, for immigrants from Europe, North-America and Oceania; and 773, 106 and six, respectively for immigrants from Africa, Asia and South America. The notification rate was highest among immigrants from Somalia (2057), Pakistan (1868) and Iraq (1616). Differences between immigrants and non-immigrants increased when adjusting for age, especially for mortality. Immigrants had a high number of hospitalizations relative to notified cases compared to non-immigrants. Although the overall COVID-19 notification rate was higher in Oslo than outside of Oslo, the notification rate among immigrants compared to non-immigrants was not higher in Oslo than outside. Conclusions: We observed a higher COVID-19 notification rate in immigrants compared to non-immigrants and much higher hospitalization rate, with major differences between different immigrant groups. Somali-, Pakistani- and Iraqi-born immigrants had especially high rates.
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Kim, D., M. Lee, B. Kim, K. Lee, and Y. Hong. "Use of complementary and alternative medicine in Korean cancer patients: Results of a survey from the Korean Cancer Study Group (KCSG)." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 17061. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.17061.
Повний текст джерелаАнотація:
17061 Background: The aim of this study was to explore the use of complementary and alternative medicine (CAM) in cancer patients of Korea. This study was performed to identify the prevalence, types, subjective effects, and side effects of CAM use, reasons for CAM use, and patients' expectations of doctors regarding their CAM use among Korean cancer patients. Methods: From August to December, 2006, face to face structured interviews were conducted and the data were analyzed in the KCSG. Results: A total 251 patients were recruited. 84% of patients had used at least one type of CAM since the time of initial diagnosis. The most prevalent types of CAM used by these patients included special diet (60%), ginseong (54%), medicinal mushrooms (50%). Energy therapies, acupuncture and spiritual therapy were used uncommonly. The main reported reason for the use of CAM was to feel hopeful. Patients expected that CAM could cure cancer (64%) and improve immune system (52%). 62 % of patients did not inform their physicians about their CAM use. Patients attributed the reason of nondisclosure that physicians never asked about CAM (43%) and physicians would disapprove the CAM use (23%). 6% of CAM users experienced side effects. Demographic variables were not predictive for the use of CAM. 60% of patients wanted to get more information about CAM with their doctors. Conclusions: More than two-thirds of cancer patients used various kinds of CAM. Physicians treating cancer patients should aware of the frequency of CAM use and should share their opinion about CAM use with cancer patients. In order to help patients make informed decisions, physician should pay more attention to CAM for making appropriate utilization of CAM. No significant financial relationships to disclose.
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Rosker, Christian, Birgit Lohberger, Doris Hofer, Bibiane Steinecker, Stefan Quasthoff, and Wolfgang Schreibmayer. "The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel." American Journal of Physiology-Cell Physiology 293, no. 2 (August 2007): C783—C789. http://dx.doi.org/10.1152/ajpcell.00070.2007.
Повний текст джерелаАнотація:
The blocking efficacy of 4,9-anhydro-TTX (4,9-ah-TTX) and TTX on several isoforms of voltage-dependent sodium channels, expressed in Xenopus laevis oocytes, was tested (Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, and Nav1.8). Generally, TTX was 40–231 times more effective, when compared with 4,9-ah-TTX, on a given isoform. An exception was Nav1.6, where 4,9-ah-TTX in nanomole per liter concentrations sufficed to result in substantial block, indicating that 4,9-ah-TTX acts specifically at this peculiar isoform. The IC50 values for TTX/4,9-ah-TTX were as follows (in nmol/l): 7.8 ± 1.3/1,260 ± 121 (Nav1.2), 2.8 ± 2.3/341 ± 36 (Nav1.3), 4.5 ± 1.0/988 ± 62 (Nav1.4), 1,970 ± 565/78,500 ± 11,600 (Nav1.5), 3.8 ± 1.5/7.8 ± 2.3 (Nav1.6), 5.5 ± 1.4/1,270 ± 251 (Nav1.7), and 1,330 ± 459/>30,000 (Nav1.8). Analysis of approximal half-maximal doses of both compounds revealed minor effects on voltage-dependent activation only, whereas steady-state inactivation was shifted to more negative potentials by both TTX and 4,9-ah-TTX in the case of the Nav1.6 subunit, but not in the case of other TTX-sensitive ones. TTX shifted steady-state inactivation also to more negative potentials in case of the TTX-insensitive Nav1.5 subunit, where it also exerted profound effects on the time course of recovery from inactivation. Isoform-specific interaction of toxins with ion channels is frequently observed in the case of proteinaceous toxins. Although the sensitivity of Nav1.1 to 4,9-ah-TTX is not known, here we report evidence on a highly isoform-specific TTX analog that may well turn out to be an invaluable tool in research for the identification of Nav1.6-mediated function, but also for therapeutic intervention.
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Ackermann, Ole, Piotr Wojciechowski, Maria Dzierzega, Kay Grosser, Ansgar Schmitz-Franken, Henrik Rudolf, and Kolja Eckert. "Sokrat II – An International, Prospective, Multicenter, Phase IV Diagnostic Trial to Evaluate the Efficacy of the Wrist SAFE Algorithm in Fracture Sonography of Distal Forearm Fractures in Children." Ultraschall in der Medizin - European Journal of Ultrasound 40, no. 03 (February 5, 2019): 349–58. http://dx.doi.org/10.1055/a-0825-6284.
Повний текст джерелаАнотація:
Abstract Background Distal forearm fractures are the most common fractures in childhood and can be diagnosed with ultrasound. The aim of this study was to demonstrate the eligibility of Wrist SAFE for clinical use and the avoidance of X-ray application in children. Methods We enrolled patients from 0 – 12 years with suspected distal forearm fractures. They were treated according to the Wrist SAFE algorithm, a detailed pathway for ultrasound fracture diagnosis, treatment decisions and control options. Additionally, 9 clinical predictors were tested. Depending on sonographic and clinical findings, patients were treated with functional movement, immobilization or surgery. Follow-up was conducted after 5 days and 3 months. Results 16 physicians (6 specialists, 10 assistants) at 5 study sites examined 498 (234 boys, 251 girls, 13 not specified) patients with ultrasound, age 8.4 (0 – 12) years. 321 (64 %) patients were diagnosed with a fracture, 5 (0.8 %) with suspected fracture; X-rays were conducted in 58 cases (12 %), 9 (1.8 %) of them on day 1 and 49 (9.8 %) on day 5; sonographic diagnosis was confirmed in 57 of 58 (98 %) cases; in one case, the sonographic diagnosis of “contusion” was revised to “radius fracture”. 381 patients (77 %) underwent final follow-up after an average of 96 (62 – 180) days. All patients were symptom-free at that time. Palpatory bone pain over the radius/ulna and swelling were identified as clinical predictors. 81 % of X-rays were avoided. Conclusion Wrist SAFE enables the safe diagnosis and therapy of distal forearm fractures in children. Findings can be reviewed safely, also enabling physicians in training to use the method. 81 % of X-rays can be avoided, a figure that corresponds to 2.8 million X-rays in the G10 member states. After performing 100 examinations, physician have acquired the necessary sonography skills.
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Dong, W. K., T. Shiwaku, Y. Kawakami, and E. H. Chudler. "Static and dynamic responses of periodontal ligament mechanoreceptors and intradental mechanoreceptors." Journal of Neurophysiology 69, no. 5 (May 1, 1993): 1567–82. http://dx.doi.org/10.1152/jn.1993.69.5.1567.
Повний текст джерелаАнотація:
1. The response properties of 39 periodontal ligament mechanoreceptors (PDLMs) and 12 intradental mechanoreceptors (IMs) related to the intact mandibular canine tooth were isolated by extracellular recording methods from the ipsilateral trigeminal semilunar ganglion. 2. The stimulus threshold and response magnitude of individual PDLMs depended on the direction of steady force applied to the intact canine tooth. Canine PDLMs as a population, however, did not have a preferred stimulus direction. IMs were activated only by a rapid mechanical transient applied to the intact tooth in any direction. The stimulus threshold and response magnitude of each IM were approximately equipotent in all stimulus directions. 3. Application of quantifiable ramp-and-hold stimulation showed that PDLMs can encode the intensity of steady forces as well as the rate of force ramps. Increasing the ramp rates decreased the total ramp discharge but increased the peak discharge frequency. IMs encoded only the rate of force ramps that were applied by percussion. Higher ramp rates increased both the total discharges and peak discharge frequency of IMs. 4. The dynamic response properties of PDLMs and IMs were clearly differentiated by sinusoidal vibratory stimulation. The maximum frequencies for entrainment of IM discharge at the stimulus cycle length (251 +/- 103 Hz, mean +/- SD) and at any periodicity including multiples of the stimulus cycle length (295 +/- 100 Hz) were significantly higher than the maximum frequencies for PDLM discharge entrainment at the stimulus cycle length (103 +/- 53 Hz) and at any periodicity (133 +/- 62 Hz). 5. The functional similarities of PDLMs and IMs, respectively, to slowly adapting type II mechanoreceptors and Pacinian corpuscle receptors in the skin are discussed. Our present findings, which complement earlier anatomic and behavioral evidence, strongly suggest that IMs subserve nonnociceptive and nonpain functions. Both PDLMs and IMs may provide a continuum of dynamic afferent inputs necessary for tactile sensibility of teeth.
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Fonseca, Rafael, Emily A. Blood, Martin M. Oken, Robert A. Kyle, Gordon W. Dewald, Richard J. Bailey, Scott A. Van Wier, et al. "Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients." Blood 99, no. 10 (May 15, 2002): 3735–41. http://dx.doi.org/10.1182/blood.v99.10.3735.
Повний текст джерелаАнотація:
The t(11;14)(q13;q32) results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma, where it is also associated with a lymphoplasmacytic morphology. We performed an interphase fluorescent in situ hybridization (FISH) study to determine the clinical and biologic significance of the abnormality when testing a large cohort of myeloma patients. Bone marrow slides from multiple myeloma patients entered into the Eastern Cooperative Oncology Group phase III clinical trial E9486 and associated laboratory correlative study E9487 were analyzed using interphase FISH combined with immune-fluorescent (cytoplasmic immunoglobulin–FISH) detection of clonal plasma cells. We used FISH probes that hybridize to the 14q32 and 11q13 chromosomal loci. The t(11;14)(q13;q32) was correlated with known biologic and prognostic factors. Of 336 evaluable patients, 53 (16%) had abnormal FISH patterns compatible with the t(11;14)(q13;q32). These patients appeared to be more likely to have a serum monoclonal protein of less than 10 g/L (1 g/dL) (28% vs 15%, P = .029) and a lower plasma cell labeling index (P = .09). More strikingly, patients were less likely to be hyperdiploid by DNA content analysis (n = 251, 14% vs 62%, P < .001). Patients with the t(11;14)(q13;q32) appeared to have better survival and response to treatment, although this did not reach statistical significance. Multiple myeloma with the t(11;14)(q13;q32) is a unique subset of patients, not only characterized by cyclin D1 up-regulation and a lymphoplasmacytic morphology, but is also more frequently associated with small serum monoclonal proteins and is much less likely to be hyperdiploid. These patients do not have a worsened prognosis as previously thought.
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Nicholson, Jill, and Paul J. Kelly. "Prospectively collected baseline erectile function (EF) in 1,173 consecutive newly diagnosed prostate cancer patients referred for radiotherapy." Journal of Clinical Oncology 35, no. 6_suppl (February 20, 2017): 89. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.89.
Повний текст джерелаАнотація:
89 Background: Preservation of EF is a goal of care for many men with newly diagnosed prostate cancer. In order to accurately counsel patients regarding their likely treatment outcome, an assessment of baseline EF, and screening for known risk factors, should form part of the assessment of all prostate cancer patients. Methods: We performed a retrospective review of prospectively-collected data regarding baseline EF in men with prostate cancer referred for a radiotherapy opinion. 1173 consecutive patients referred over a 5.5 year period from 2011-16 were included. All patients were offered the opportunity to complete the International Index of Erectile Function (IIEF-5) questionnaire in privacy. Information on known risk factors such as age, vascular comorbidity, smoking and alcohol history, and cardiovascular risk factors was recorded. Results: Of the 1173 patients, 233 were excluded due to metastatic disease at referral. Of the remaining 940 with localised disease, 812 (86%) completed the questionnaire. 561 (69%) successfully filled the questionnaire yielding a score. A further 251 (31%) commented on the questionnaire without completing the score (see table). Median age was 66years (IQR 62-71). 574(61%) had known risk factors for erectile dysfunction such as hypertension or diabetes. 173 (18.5%) had a history of peripheral, cardiovascular, or cerebrovascular disease. Smoking and alcohol history was available for 645 patients, 353(60%) had a smoking history, and 450(70%) had a history of alcohol use. Conclusions: In this population, there is a high prevalence of baseline erectile dysfunction (IIEF-5 ≤16), 242/561 (43%). Additionally, significant numbers of patients were sexually inactive or unconcerned regarding ED. Known risk factors for erectile dysfunction were common in this population, many of which are modifiable. [Table: see text]
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Zadvornov, A. A., and E. V. Grigoriev. "Diagnostic and predictive value of aEEG in newborns in critical state under sedation." Messenger of ANESTHESIOLOGY AND RESUSCITATION 16, no. 6 (January 27, 2020): 23–29. http://dx.doi.org/10.21292/2078-5658-2019-16-6-23-29.
Повний текст джерелаАнотація:
The objective: to study the diagnostic and prognostic value of amplitude-integrated electroencephalography (aEEG) in sedated neonates in critical state, through testing the level of S100B protein. Subjects and methods: 44 patients were enrolled in the study. The study group included patients with pathological patterns of 24-hour aEEG, in the control group, all patients had normal patterns. The level of serum S100B protein was compared in the groups on the 1st and 7th day of life as well as the early neurological outcome which was used to assess the prognostic significance of aEEG. In addition, the cut-off point of S100B in predicting an adverse outcome was estimated.Results. There were no significant difference in the level of S100B of the 1st day of life between the groups, however, there was a correlation between the severity of depression of electrocortical activity and the level of S100B protein (tau = -0.36, p < 0.001). On the 7th day of life, the level of S100B protein was significantly (p = 0.047) higher in the study group (337 (251; 819) ng/l) compared to the control group (259 (136; 354) ng/l). Elevation of S100B protein by the 7th day of life was not associated with pathological aEEG patterns or the outcome. aEEG sensitivity (Se) was 87%, specificity (Sp) ‒ 62%. The cut-off point for S100B of the first day of life was 493 ng/l with Se of 52% and Sp of 91%.Conclusion. There is a correlation between the severity of depression of electrocortical activity recorded by aEEG and S100B level on the 1st and 7th days of life,which confirms the diagnostic value of aEEG in newborns in critical state despite the use of sedation. The elevated level of S100B in the first week of life has neither diagnostic nor prognostic significance. aEEG has the highest predictive sensitivity, and S100B above 493 ng/l has the highest predictive specificity.
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Lee, Rachel M., Adriana C. Gamboa, Michael K. Turgeon, Adam Yopp, Emily L. Ryon, Joshua P. Kronenfeld, Neha Goel, et al. "The Evolving Landscape of Hepatocellular Carcinoma." American Surgeon 86, no. 7 (July 2020): 865–72. http://dx.doi.org/10.1177/0003134820939934.
Повний текст джерелаАнотація:
Background Hepatitis C virus (HCV) has historically been the most common cause of cirrhosis and hepatocellular carcinoma (HCC) in the United States. With improved HCV treatment, cirrhosis secondary to other etiologies is increasing. Given this changing epidemiology, our aim was to determine the impact of cirrhosis etiology on overall survival (OS) in patients with HCC. Methods All patients with cirrhosis and primary HCC from the US Safety Net Collaborative (2012-2014) database were included. Patients were grouped into “safety net” and “academic” based on where they received their care. The primary outcome was the OS. Results 1479 patients were included. The average age was 60 years and 78% (n = 1156) were male. 56% (n = 649) received care at academic and 44% (n = 649) at safety net hospitals. The median model for end-stage liver disease (MELD) was 10 (IQR 8-16). Median OS was 23 months. Etiology of cirrhosis was viral hepatitis 56% (n = 612), alcohol abuse 14% (n = 152), alcohol and hepatitis 23% (n = 251), and other 7% (n = 85). Patients with alcohol-related cirrhosis (alcohol alone or with hepatitis) were younger (59 vs 62 years), more likely to be male (86% vs 75%), treated at a safety net facility (45% vs 35%), uninsured (17% vs 13%), and had a higher MELD (median 12 vs 10) (all P < .003). They were less likely to have been screened for HCC within 1 year of diagnosis (20% vs 29%) and to receive treatment (69% vs 81%), and more likely to present with stage IV disease (21% vs 15%) (all P < .001). Patients with alcohol-related cirrhosis had decreased OS (5-year OS 24% vs 40%, P < .001), which persisted in a subset analysis of both academic and safety net populations. Conclusion Although not significant on MVA, alcohol-related cirrhosis is associated with all factors that correlate with decreased survival from HCC. Efforts must focus on this vulnerable patient population to optimize screening, treatment, and outcomes.
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Shen, Lin, Jun Guo, Qingyuan Zhang, Hongming Pan, Ying Yuan, Yuxian Bai, Tianshu Liu, et al. "Tislelizumab in Chinese patients with advanced solid tumors: an open-label, non-comparative, phase 1/2 study." Journal for ImmunoTherapy of Cancer 8, no. 1 (June 2020): e000437. http://dx.doi.org/10.1136/jitc-2019-000437.
Повний текст джерелаАнотація:
BackgroundTislelizumab is an investigational, humanized, IgG4 monoclonal antibody with high affinity and binding specificity for programmed cell death-1 (PD-1) that was engineered to minimize binding to FcγR on macrophages in order to abrogate antibody-dependent phagocytosis, a mechanism of T-cell clearance and potential resistance to anti-PD-1 therapy.MethodsThe purpose of this phase 1/2, open-label, non-comparative study was to examine the safety, tolerability, and antitumor activity of tislelizumab in adult (≥18 years) Chinese patients with histologically or cytologically confirmed advanced solid tumors with measurable disease. The phase 1 portion of the study consisted of a dose-verification study and a pharmacokinetic (PK) substudy; phase 2 was an indication-expansion study including 11 solid tumor cohorts. Patients previously treated with therapies targeting PD-1 or its ligand, programmed cell death ligand-1 were excluded. During dose-verification, dose-limiting toxicities (DLTs) were monitored; safety and tolerability were examined and the previously determined recommended phase 2 dose (RP2D) was verified. The primary endpoint of phase 2 was investigator-assessed objective response rate per Response Evaluation Criteria in Solid Tumors V.1.1.ResultsAs of December 1, 2018, 300 patients were treated with tislelizumab 200 mg intravenously once every 3 weeks (Q3W). Median duration of follow-up was 8.1 months (range 0.2–21.9). No DLTs were reported during the phase 1 dose-verification study and the RP2D was confirmed to be 200 mg intravenously Q3W. Most treatment-related adverse events (62%) were grade 1 or 2, with the most common being anemia (n=70; 23%) and increased aspartate aminotransferase (n=67; 22%). Of the 251 efficacy evaluable patients, 45 (18%) achieved a confirmed clinical response, including one patient from the PK substudy who achieved a complete response. Median duration of response was not reached for all except the nasopharyngeal carcinoma cohort (8.3 months). Antitumor responses were observed in multiple tumor types.ConclusionsTislelizumab was generally well tolerated among Chinese patients. Antitumor activity was observed in patients with multiple solid tumors.Trial registration numberCTR20160872.
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ÁLVAREZ-ORTEGA, SERGIO, JOAQUÍN ABOLAFIA, GRACIA LIÉBANAS, and REYES PEÑA-SANTIAGO. "Studies on the genus Aporcelaimellus Heyns, 1965 (Nematoda, Dorylaimida, Aporcelaimidae). Four new species with complex uterus from Southeastern Iberian Peninsula." Zootaxa 3551, no. 1 (November 16, 2012): 1. http://dx.doi.org/10.11646/zootaxa.3551.1.1.
Повний текст джерелаАнотація:
Four new species with complex uterus of the genus Aporcelaimellus, collected mainly in natural areas in the IberianPeninsula, are identified and described here. Aporcelaimellus alpujarrensis sp. n. is characterized by having body1.72–1.91 mm long, lip region offset by constriction and 14–15μm broad, odontostyle 14–16μm long with apertureoccupying 67–70% its length, neck about 455μm long, pharyngeal expansion about 224μm long, uterus tripartite and145–206μm long, V = 53–55, tail convex conoid (27–34μm, c = 55–71, c’ = 0.9–1.1), spicules 56–60μm long, and 7–9irregularly spaced ventromedian supplements with hiatus. Aporcelaimellus castaneanus sp. n. is characterized by havingbody 2.18–2.83 mm long, lip region offset by constriction and 20–23μm broad, odontostyle 22–24μm long with apertureoccupying 62–67% its length, neck 581–662μm long, pharyngeal expansion 300–355μm long, uterus tripartite and164–348μm long, V = 52–58, tail conical with rounded terminus (44–52μm, c = 48–60, c’ = 0.8–1.1), spicules 94–103μm long, and 14–15 irregularly spaced ventromedian supplements which lack hiatus. Aporcelaimellus communis sp. n. ischaracterized by having body 2.56–4.22 mm long, lip region offset by constriction and 19–25μm broad, odontostyle19–26μm long with aperture occupying 64–74% its length, neck 595–750μm long, pharyngeal expansion 321–427μmlong, uterus bipartite and 190–450μm long, V = 51–60, tail short and convex conoid (29–50μm, c = 63–109, c’ = 0.5–1.0),spicules 89–118μm long, and 16–25 irregularly spaced ventromedian supplements with hiatus. Aporcelaimellus tenuis sp.n. is characterized by having body 1.89–2.70 mm long and comparatively slender (a = 35–49), lip region offset byconstriction and 15–18μm broad, odontostyle 15–21μm long with aperture occupying 60–70% of its length, neck488–645μm long, pharyngeal expansion 251–366μm long, uterus bipartite and 135–213μm long, V = 55–58, tail convexconoid with rounded terminus (25–40μm, c = 64–92, c’ = 0.8–1.1), spicules 52–66μm long, and 11–12 irregularly spaced SEM pictures, are given for the four species.ventromedian supplements with hiatus. Measurements and illustrations, including line drawings, LM pictures and and/or
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Agbeno, Evans Kofi, Joseph Osarfo, Gloria Brempomaa Owusu, Douglas Opoku Aninng, Betty Anane-Fenin, Judith Agyemang Amponsah, Joycelyn A. Ashong, et al. "Knowledge of hypertensive disorders of pregnancy among pregnant women attending antenatal clinic at a tertiary hospital in Ghana." SAGE Open Medicine 10 (January 2022): 205031212210884. http://dx.doi.org/10.1177/20503121221088432.
Повний текст джерелаАнотація:
Objectives: Hypertensive disorders of pregnancy contribute significantly to maternal and neonatal morbidity and mortality globally. Health-seeking behaviour is influenced by adequate knowledge of the condition. However, current data on pregnant women’s knowledge of the condition and health-seeking behaviour are relatively scant in Ghana and has not been previously studied in the Central Region where hypertensive disorders of pregnancy was the leading cause of maternal mortality from 2016 to 2018. The study sought to generate data to fill this knowledge gap. Methods: A cross-sectional study was conducted among 404 pregnant women attending antenatal clinic at the Cape Coast Teaching Hospital from 1 April to 30 September 2020. Data on sociodemographic characteristics, including age, level of education and parity, and knowledge of hypertensive disorders of pregnancy, including its risk factors, clinical presentations and complications, were collected using structured questionnaires. The outcome variable, knowledge of hypertensive disorders of pregnancy, was a composite variable categorized as adequate and inadequate knowledge. Descriptive statistics were generated and association between independent and outcome variables were explored using chi-square and Fisher’s exact tests and logistic regression methods. Results: Sixty-two participants (15.4%) showed adequate knowledge of hypertensive disorders of pregnancy. About 62% (251/404) of respondents had heard about hypertensive disorders of pregnancy. Of those who had heard of hypertensive disorders of pregnancy, 29.4% (72/245) correctly indicated the condition was underlined by hypertension in pregnancy ⩾ 20 weeks gestation. Women with tertiary education were six times more likely to have adequate hypertensive disorders of pregnancy knowledge than those with basic education. Women with parity 1–4 were 52% less likely to have adequate knowledge compared to nulliparous women. Conclusion: The remarkably low proportion of pregnant women with adequate knowledge of hypertensive disorders of pregnancy in the study is worrisome because of its potential adverse implication for the health of mothers and their babies. Re-packaging the antenatal health education programme and its delivery is needed for greater impact as far as hypertensive disorders of pregnancy morbidity/mortality is concerned.
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Choi, Minsu, Teak Jun Shin, Byung Hoon Kim, Chun Il Kim, Kyung Seop Lee, Seock Hwan Choi, Hyun Tae Kim, et al. "Trends of First-Line Targeted Therapy in Korean Patients With Metastatic Clear Cell Renal Cell Carcinoma: Sunitinib Versus Pazopanib, a Multicenter Study." Korean Journal of Urological Oncology 20, no. 2 (May 31, 2022): 115–22. http://dx.doi.org/10.22465/kjuo.2022.20.2.115.
Повний текст джерелаАнотація:
Purpose: There have been few reports on comparison between sunitinib and pazopanib as first-line targeted therapy in Korean metastatic clear cell renal cell carcinoma (ccRCC). We sought to analyze the treatment trends of metastatic ccRCC by comparing the effects and adverse events of sunitinib and pazopanib.Materials and Methods: Data of 357 metastatic RCC patients who received the sunitinib or pazopanib as the first-line targeted therapy from the Daegyeong Oncology Study Group database was obtained and analyzed. Among these patients, patients who only clear cell type was confirmed after needle biopsy or nephrectomy were included, and patients who underwent target therapy for less than 3 months were excluded.Results: Of 251 patients who met the inclusion criteria, sunitinib and pazopanib group were identified in 156 (62%) and 95 patients (38%), respectively. Pazopanib group was older (66 years vs. 61 years, p=0.001) and more symptomatic (65% vs. 52%, p=0.037) and had more patients with Karnofsky performance status <80 (20% vs. 11%, p=0.048) and fewer number of organ metastases (p=0.004) compared to sunitinib group. There was no significant difference in disease control rate (88.5% vs. 87.3%, p=0.744), the median progression-free survival (19 months vs. 15 months, p=0.444) and overall survival (25 months vs. 19 months, p=0.721) between sunitinib and pazopanib. The most common grade 3/4 adverse events with sunitinib and pazopanib were anemia (5%) and hand-foot syndrome (3%), respectively. There was no significant difference between sunitinib and pazopanib in number of patients who experienced grade 3/4 adverse events (15% vs. 11%, p=0.275). However, there were more patients who discontinued treatment due to only adverse events in sunitinib group compared to pazopanib group (12% vs. 3%, p=0.020).Conclusions: In Korean metastatic ccRCC, pazopanib tended to be used in patients with poorer health status compared to sunitinib. Sunitinib and pazopanib had no significant difference in treatment effect and survival, but pazopanib had more tolerable adverse events.
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Kham, Shirley Kow Yin, Toon Chai Foo, Ariffin Hany, Yiong Huak Chan, Hai Peng Lin, Thuan Chong Quah, and Allen Eng Juh Yeoh. "Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Decreases Risk of Childhood Acute Lymphoblastic Leukemia (ALL): A Study of the Chinese and Malay Population." Blood 106, no. 11 (November 16, 2005): 1459. http://dx.doi.org/10.1182/blood.v106.11.1459.1459.
Повний текст джерелаАнотація:
Abstract MTHFR plays a key role in folate metabolism by shuttling one-carbon units between nucleotide synthesis and methylation reactions. Two frequent polymorphisms in the human MTHFR gene (C677T and A1298C) confer moderate functional impairment of MTHFR activity for homozygous mutant individuals. These polymorphisms have been inconclusively shown to confer some form of protection against development of cancer. We postulate that MTHFR polymorphisms influence risk of developing childhood ALL by comparing the frequency of these polymorphisms in normal controls and children with ALL in their specific races. As the frequencies of these polymorphisms are unknown in Chinese and Malays populations, we performed a population study among Chinese and Malay populations, and children with ALL. A total of 310 childhood ALL were enrolled between 1992–2005 (NUH-ALL 92, HK-ALL 98, MASPORE-ALL 2003). The cases comprise of 202 Chinese ALL (B-lineage=180, T-lineage=15, infant=7) and 108 Malay ALL (B-lineage=98, T-lineage=3, infant=7). A total of 231 cases (Ch=144, Mal=87) were screened for TEL-AML1 and MLL rearrangements using RT-PCR. Umblical cord bloods (anonymous) were used as controls. Genotyping was carried out using PCR/RFLP. The frequencies of MTHFR polymorphisms were distinctly different among the Chinese and Malay populations. 54.2% of the Chinese population was either heterozygous (45%) or homozygous (9.2%) for MTHFR C677T while only 25.5% of the Malay population were either heterozygous (23.9%) or homozygous (1.6%). The frequency of MTHFR C677T polymorphism among the ALL patients were significantly different from the normal population (Chinese p=0.01, Malay p= 0.068). Specifically, the frequencies of heterozygous and homozygous for C677T among ALL patients were lower compared to the normal population: Chinese ALL 33.7% and 8.9%; Malays ALL 15.7% and 1%. The protection against childhood ALL seems to be conferred to reducing the risk of developing TEL-AML1 subtype (Table 2). This may explain the reason why the frequency of TEL-AML1 subtype is lower among the Chinese compared to the Malays (24/144 [16.7%] Chinese vs 22/87 [25.3%] Malays). No significant association of MTHFR A1298C with risk of childhood ALL. Our findings suggested that MTHFR C677T significantly reduces the risk of developing childhood leukaemia especially those with onset in utero. Table 1: Frequency of the MTHFR C677T genotypes in childhood ALL and controls (A) Chinese Genotype Controls (n=262) ALL (n=202) OR(95%CI) p CC 119(45.4%) 116(57.4%) 1.0(referent) - CT or TT 143(54.2%) 86(42.6%) 1.6(1.1–2.3) 0.01 (B) Malays Controls(n=251) ALL(n=108) CC 187(74.5%) 90(83.3%) 1.0(referent) - CT or TT 64(25.5%) 18(16.7%) - 0.068 Table 2: Distribution of MTHFR C677T genotypes in the 3 subgroups. (A) Chinese Controls TEL-AML1 or MLL TEL-AML1 or MLL Hyperdiploidy Non-hyperderploidy Genotype (n=262) Present(n=32; MLL=8/32) Absent(n=112) (n=22) (n=50) CC 119(45.4%) 19(59.3%) 62(55.4%) 16(72.7%) 26(52%) CT or TT 143(54.2%) 13(40.6%) p=0.045 50(44.7%) p=0.129 6(27.3%) p<0.0001 24(48%) p=0.24 (B) Malays Genotype Controls(n=251) Present(n=26; MLL=4/26) Absent(n=61) CC 187(74.5%) 24(92.3%) 48(78.7%) No Data No Data CT or TT 64(25.5%) 2(7.7%) p=0.001 13(21.3%) p=0.27