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Статті в журналах з теми "572.869 2":
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Caldwell, Aaron R., Megan E. Rosa-Caldwell, Carson Keeter, Evan C. Johnson, François Péronnet, and Matthew S. Ganio. "Effects of a 14-Day Hydration Intervention on Individuals with Habitually Low Fluid Intake." Annals of Nutrition and Metabolism 76, Suppl. 1 (2020): 67–68. http://dx.doi.org/10.1159/000515375.
Анотація:
<b><i>Background:</i></b> Debate continues over whether or not individuals with low total water intake (TWI) are in a chronic fluid deficit (i.e., low total body water) [<xref ref-type="bibr" rid="ref1">1</xref>]. When women with habitually low TWI (1.6 ± 0.5 L/day) increased their fluid intake (3.5 ± 0.1 L/day) for 4 days 24-h urine osmolality decreased, but there was no change in body weight, a proxy for total body water (TBW) [<xref ref-type="bibr" rid="ref2">2</xref>]. In a small (<i>n</i> = 5) study of adult men, there were no observable changes in TBW, as measured by bioelectrical impedance, after increasing TWI for 4 weeks [<xref ref-type="bibr" rid="ref3">3</xref>]. However, body weight increased and salivary osmolality decreased indicating that the study may have been underpowered to detect changes in TBW. Further, no studies to date have measured changes in blood volume (BV) when TWI is increased. <b><i>Objectives:</i></b> Therefore, the purpose of this study was to identify individuals with habitually low fluid intake and determine if increasing TWI, for 14 days, resulted in changes in TBW or BV. <b><i>Methods:</i></b> In order to identify individuals with low TWI, 889 healthy adults were screened. Participants with a self-reported TWI less than 1.8 L/day (men) or 1.2 L/day (women), and a 24-h urine osmolality greater than 800 mOsm were included in the intervention phase of the study. For the intervention phase, 15 participants were assigned to the experimental group and 8 participants were assigned to the control group. The intervention period lasted for 14 days and consisted of 2 visits to our laboratory: one before the intervention (baseline) and 14 days into the intervention (14-day follow-up). At these visits, BV was measured using a CO-rebreathe procedure and deuterium oxide (D<sub>2</sub>O) was administered to measure TBW. Urine samples were collected immediately prior, and 3–8 h after the D<sub>2</sub>O dose to allow for equilibration. Prior to each visit, participants collected 24-h urine to measure 24-h hydration status. After the baseline visit, the experimental group increased their TWI to 3.7 L for males and 2.7 L for females in order to meet the current Institute of Medicine recommendations for TWI. <b><i>Results:</i></b> Twenty-four-hour urine osmolality decreased (−438.7 ± 362.1 mOsm; <i>p</i> < 0.001) and urine volume increased (1,526 ± 869 mL; <i>p</i> < 0.001) in the experimental group from baseline, while there were no differences in osmolality (−74.7 ± 572 mOsm; <i>p</i> = 0.45), or urine volume (−32 ± 1,376 mL; <i>p</i> = 0.89) in the control group. However, there were no changes in BV (Fig. <xref ref-type="fig" rid="f01">1</xref>a) or changes in TBW (Fig. <xref ref-type="fig" rid="f01">1</xref>b) in either group. <b><i>Conclusions:</i></b> Increasing fluid intake in individuals with habitually low TWI increases 24-h urine volume and decreases urine osmolality but does not result in changes in TBW or BV. These findings are in agreement with previous work indicating that TWI interventions lasting 3 days [<xref ref-type="bibr" rid="ref2">2</xref>] to 4 weeks [<xref ref-type="bibr" rid="ref3">3</xref>] do not result in changes in TBW. Current evidence would suggest that the benefits of increasing TWI are not related changes in TBW.
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Pramoda, R., N. Shafitri, B. V. Indahyanti, A. Zulham, S. Koeshendrajana, C. Yuliaty, U. Muawanah, et al. "Utilization of fish resources in the Indonesia’s Exclusive Economic Zone within the Fishery Management Area of 573: Case study in Rote Ndao Regency." IOP Conference Series: Earth and Environmental Science 869, no. 1 (November 1, 2021): 012018. http://dx.doi.org/10.1088/1755-1315/869/1/012018.
Анотація:
Abstract The United Nations Convention on the Law of the Sea (UNCLOS 1982) affirms that the government has sovereign rights, jurisdiction, and obligations in Indonesia’s EEZ. Indonesia has an interest in protecting sovereign rights and increasing state revenues in the waters of the Exclusive Economic Zone (EEZ). That sovereign right is to use fishery resources responsibly for the benefit of the nation and society as a whole. The sole purpose of this qualitative research is to optimize fisheries utilization in the Rote Ndao Regency whose waters include the Fisheries Management Area of 573 (FMA-573) in the EEZ. The analysis had been carried out with a case study approach and then descriptively elaborated. The results showed that: 1) the use of fisheries in FMA-573 was carried out by traditional fishermen (using vessels ≤10 Gross Tonnage/GT) and fishermen using vessels >29 GT; 2) supervision is still needed for the improvement of ships and human resources; 3) there are still violations of territorial waters by traditional Indonesian fishermen. The policy recommendations that must be carried out by the government are: 1) encouraging local fishermen to catch fish in the FMA-573 area by providing stimulus for ships and fishing gear; 2) allocate budget to purchase a new fleet of ships and add supervisors; 3) increase the number of fishery instructors to foster and socialize the boundaries of Indonesia’s EEZ with Australia.
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Duraes, Eliana F., Mohammed Asif, Ashley Modica, Giulia Sikorski, C. Scott Hultman, and Julie Caffrey. "863 Drug Addiction and Opioid Use in the Acute Burn Patient." Journal of Burn Care & Research 41, Supplement_1 (March 2020): S269—S270. http://dx.doi.org/10.1093/jbcr/iraa024.429.
Анотація:
Abstract Introduction In light of the opioid crisis, there is an increased interest in the acute pain management of patients with history of drug addiction. There is no consensus on pain management among different burn centers and the amount of narcotic prescription reportedly doubled over a seven year period according to Tully in 20191. Our aim was to study the association of previous drug addiction history and the treatment of acute burn patients with special interest on the daily morphine equivalent requirements. Methods A prospectively maintained database was queried to study acute burn patients admitted in a reference burn center from 2013 to 2018. Patients with a previous history of drug addiction (group 1) were compared to patients without it (group 2). Drug abuse was defined as patients with history of opioids abuse, heroin, cocaine, cannabis, inhalants, and alcoholism, specifically those with diagnostic codes on file. The expected mortality was calculated using the Premier® database. A p0.05 was considered significant. Results A total of 3046 patients were studied, 502 (16.5%) had previous history of drug abuse on file. Compared to group 2, group 1 had: more males - 343 (68.3%) vs 1456 (57.2%) p0.001; was younger - 45.7914.65 vs 52.0219.57 p0.001; required intubation at a higher rate - 100 (19.9%) vs 329 (12.9%) p0.001; longer intubation period - 2.4310.05 vs 1.377.71 p0.001; had a prolonged admission - 13.8728.82 vs 8.4816.58 p0.001; more surgeries - 1.213.30 vs 0.71.58 p=0.002, and a higher daily morphine milligram equivalent requirement - 148.34320.56 vs 56.0297.81 p0.001. The groups had similar expected mortality rates: 3.03% vs 3.56%p=0.483; which may be partly explained by the fact that the drug use history is not accounted for on the formula. No significant difference was seen on the burned area between the groups. Conclusions Drug addiction was associated with increased need for intubation and length of intubation, prolonged admission, increased surgery rate and a higher daily morphine equivalent usage. Further studies are necessary guide the treatment of the specific needs of these increasingly common burn patients subgroup and also to define the need of including the history of drug use on the expected mortality rate formula. Applicability of Research to Practice This study adds to the literature differences in the treatment of burn patients with history of drug addiction and highlights the need for specific protocols for improved care.
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Zhang, Jian Hui, Jian Wu, Petre Alexandrov, Terry Burke, Kuang Sheng та Jian Hui Zhao. "1836 V, 4.7 mΩ•cm2 High Power 4H-SiC Bipolar Junction Transistor". Materials Science Forum 527-529 (жовтень 2006): 1417–20. http://dx.doi.org/10.4028/www.scientific.net/msf.527-529.1417.
Анотація:
This paper reports recent progress in the development of high power 4H-SiC BJTs based on an improved device design and fabrication scheme. Near theoretical limit high blocking voltage of VCEO=1,836 V has been achieved for 4H-SiC BJTs based on a drift layer of only 12 μm, doped to 6.7x1015 cm-3. The collector current measured for a single cell BJT with an active area of 0.61 mm2 is up to IC=9.87 A (JC=1618 A/cm2). The collector current is 7.64 A (JC=1252 A/cm2) at VCE=5.9 V in the saturation region, corresponding to an absolute specific on-resistance (RSP_ON) of 4.7 m9·cm2. From VCE=2.4 V to VCE= 5.8 V, the BJT has a differential RSP_ON of only 3.9 m9·cm2. The current gain is about 8.8 at Ic=5.3 A (869 A/cm2). This 4H-SiC BJT shows a V2/RSP_ON of 717 MW/cm2, which is the highest value reported to date for high-voltage and high-current 4H-SiC BJTs. A verylarge area 4H-SiC BJT with an active area of 11.3 mm2 is also demonstrated.
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Ciombor, Kristen Keon, Jennifer Whisenant, Dana Backlund Cardin, Laura Williams Goff, Satya Das, Michael Schulte, Allison Cohen, et al. "CB-839, panitumumab, and irinotecan in RAS wildtype (WT) metastatic colorectal cancer (mCRC): Phase I results." Journal of Clinical Oncology 37, no. 4_suppl (February 1, 2019): 574. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.574.
Анотація:
574 Background: Epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) are approved in RAS WT mCRC; however, patients (pts) will develop resistance to these agents. Alterations in glutamine (Gln) metabolism play a critical role in cancer cell growth. In cancers such as CRC, EGFR and Gln cooperate to provide signals and fuel for mitogen activated protein kinase-dependent cell growth. Our in vitro data show that Gln abrogates EGFR inhibition, and blockade of Gln transport restores sensitivity. We also observed a greater antitumor response in vivo with EGFR mAb plus CB-839, an inhibitor of a rate-limiting enzyme of Gln metabolism, than either agent alone. We designed a phase I/II study (NCT03263429) to evaluate CB-839 + panitumumab + irinotecan in anti-EGFR refractory RAS WT mCRC. Methods: Dose escalation used a Bayesian continual reassessment method targeting a 25% toxicity probability. CB-839 (600 mg or 800 mg twice daily [BID]) were evaluated with panitumumab (6 mg/kg) and irinotecan (180 mg/m2). Irinotecan was included in phase I to establish a future phase II dose of the triplet. Prior EGFR mAb treatment (tx) was not required for phase I. Dose-limiting toxicity (DLT) was any tx-related non-hematologic ≥Gr 3 toxicity (except fatigue, rash, or elevated liver enzymes) or ≥Gr 4 hematologic toxicity during the first 28 days. Results: Nine pts have been enrolled; 2 were not evaluable for DLT and replaced. Zero DLTs were observed at dose level 1 (n = 3) or 2 (n = 4); 2 more pts are needed to confirm the maximum tolerated dose (MTD). Most frequent toxicities were anemia and hypomagnesemia (88%) and elevated alkaline phosphatase, nausea, and rash (75%), most ≤Gr 2. One of 7 evaluable pts (14%) has an ongoing partial response, and 5 pts had stable disease (SD; 71%). Three pts have been on tx > 6 months, and 3 pts with prior EGFR mAb tx achieved SD. Conclusions: Triplet combination was tolerable at full doses of each drug, and preliminary antitumor activity was observed in a majority of pts. Phase II will begin after phase I completion and will evaluate efficacy of CB-839 (800 mg BID) and panitumumab (6 mg/kg). Imaging studies using investigational PET tracers to evaluate Gln metabolism as a function of tumor response are planned. Clinical trial information: NCT03263429.
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Göpfert, Eberhard, and Badisches Landesmuseum Karlsruhe. "Rezension von: Badisches Landesmuseum (Hrsg.), Die Renaissance im deutschen Südwesten ..." Württembergisch Franken 73 (October 11, 2023): 350–51. http://dx.doi.org/10.53458/wfr.v73i.8069.
Анотація:
Die Renaissance im deutschen Südwesten zwischen Reformation und Dreißigjährigem Krieg. Eine Ausstellung des Landes Baden-Württemberg vom 21.6. bis 19.10. 1986. Hrsg.: Badisches Landesmuseum Karlsruhe. Karlsruhe 1986. 975 S., Abb. (2 Bde.)Bibliotheca Palatina. Ausstellung der Universität Heidelberg in Zusammenarbeit mit der Bibliotheca Apostolica Vaticana. Katalog zur Ausstellung vom 8.7. bis 2.11.1986. Heiliggeistkirche Heidelberg. Hrsg von Elmar Mittler. Heidelberg: Edition Braus 1986. Textbd. XVI, 552 S.; Bildbd. 328 S.
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Emmerick, Isabel Cristina Martins, Mônica Rodrigues Campos, Debora Castanheira, Jessica Muzy, Aline Marques, Luisa Arueira Chaves, and Mario Jorge Sobreira da Silva. "Lung Cancer Screening in Brazil Comparing the 2013 and 2021 USPSTF Guidelines." JAMA Network Open 6, no. 12 (December 11, 2023): e2346994. http://dx.doi.org/10.1001/jamanetworkopen.2023.46994.
Анотація:
ImportanceIt is estimated that, from 2023 to 2025, lung cancer (LC) will be the second most frequent cancer in Brazil, but the country does not have an LC screening (LCS) policy.ObjectiveTo compare the number of individuals eligible for screening, 5-year preventable LC deaths, and years of life gained (YLG) if LC death is averted by LCS, considering 3 eligibility strategies by sociodemographic characteristics.Design, Setting, and ParticipantsThis comparative effectiveness research study assessed 3 LCS criteria by applying a modified version of the LC-Death Risk Assessment Tool (LCDRAT) and the LC-Risk Assessment Tool (LCRAT). Data are from the 2019 Brazilian National Household Survey. Participants included ever-smokers aged 50 to 80 years. Data analysis was performed from February to May 2023.ExposuresExposures included ever-smokers aged 50 to 80 years, US Preventive Services Task Force (USPSTF) 2013 guidelines (ever-smokers aged 55 to 80 years with ≥30 pack-years and &lt;15 years since cessation), and USPSTF 2021 guidelines (ever-smokers aged 50 to 80 years with 20 pack-years and &lt;15 years since cessation).Main Outcomes and MeasuresThe primary outcomes were the numbers of individuals eligible for LCS, the 5-year preventable deaths attributable to LC, and the number of YLGs if death due to LC was averted by LCS.ResultsIn Brazil, the eligible population for LCS was 27 280 920 ever-smokers aged 50 to 80 years (13 387 552 female [49.1%]; 13 249 531 [48.6%] aged 50-60 years; 394 994 Asian or Indigenous [1.4%]; 3 111 676 Black [11.4%]; 10 942 640 Pardo [40.1%]; 12 830 904 White [47.0%]; 12 428 536 [45.6%] with an incomplete middle school education; and 12 860 132 [47.1%] living in the Southeast region); 5 144 322 individuals met the USPSTF 2013 criteria for LCS (2 090 636 female [40.6%]; 2 290 219 [44.5%] aged 61-70 years; 66 430 Asian or Indigenous [1.3%]; 491 527 Black [9.6%]; 2 073 836 Pardo [40.3%]; 2 512 529 [48.8%] White; 2 436 221 [47.4%] with an incomplete middle school education; and 2 577 300 [50.1%] living in the Southeast region), and 8 380 279 individuals met the USPSTF 2021 LCS criteria (3 507 760 female [41.9%]; 4 352 740 [51.9%] aged 50-60 years; 119 925 Asian or Indigenous [1.4%]; 839 171 Black [10.0%]; 3 330 497 Pardo [39.7%]; 4 090 687 [48.8%] White; 4 022 784 [48.0%] with an incomplete middle school education; and 4 162 070 [49.7%] living in the Southeast region). The number needed to screen to prevent 1 death was 177 individuals according to the USPSTF 2013 criteria and 242 individuals according to the USPSTF 2021 criteria. The YLG was 23 for all ever-smokers, 19 for the USPSTF 2013 criteria, and 21 for the USPSTF 2021 criteria. Being Black, having less than a high school education, and living in the North and Northeast regions were associated with increased 5-year risk of LC death.Conclusions and RelevanceIn this comparative effectiveness study, USPSTF 2021 criteria were better than USPSTF 2013 in reducing disparities in LC death rates. Nonetheless, the risk of LC death remained unequal, and these results underscore the importance of identifying an appropriate approach for high-risk populations for LCS, considering the local epidemiological context.
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Mthembu, L., J. T. Masuka, K. Duze, and A. Mosam. "The characteristics of dermatology inpatients seen at the quaternary Inkosi Albert Luthuli Central Hospital in Durban, South Africa, over a 5-year period – 2015 - 2020." South African Medical Journal 114, no. 1 (December 31, 2023): 33–38. http://dx.doi.org/10.7196/samj.2024.v114i1.1098.
Анотація:
Background. In recent years, dermatology has been offered as an outpatient service, with decreasing inpatient dermatology admissions. However, dermatology consultation services have remained active, offering care to patients admitted for non-cutaneous indications by other specialties.Objectives. To describe the clinical spectrum and characteristics of inpatient dermatology diseases managed at a quaternary South African (SA) hospital. Methods. We retrospectively reviewed and analysed electronic records of all dermatology inpatients managed by dermatologists from 2015 to 2020 at Inkosi Albert Luthuli Central Hospital (IALCH) in Durban, South Africa. Demographic and clinical data on the International Classification of Diseases (ICD) 10 dermatology diagnosis and admitting specialty were collected and analysed. Results. A total of 4 867 patients were managed by the IALCH dermatology service during the study period. Females accounted for 2 527 (51.9%), while black African, coloured, Indian/Asian, white and unclassified patients constituted 3 146 (64.6%), 106 (2.2%), 1 129 (23.2%), 431 (8.9%) and 55 (1.1%), respectively. The median (interquartile range) age of the study population was 42.0 (28.0 - 58.0) years. Of 867 patients, 183 (3.8%) were dermatology inpatient admissions, whereas the remainder, 4 684 (96.2%), were seen as consults from other specialties. Most (1 010 (20.7%)) of the dermatology consults were received from plastic and reconstructive surgeons, while bacterial infections, decubitus ulcers and lower limb ulcers were the three most common referred diagnoses overall. Conclusion. A broad range of diagnoses is managed through the dermatology inpatient service, particularly as consultations. These services remain essential in the holistic management of patients.
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Nafiz ÜNALMIŞ, Ahmet. "KİTAP DEĞERLENDİRME-HAMİT EMRAH BERİŞ, SİYASAL DÜZENİN SINIRLARI DEMOKRASİ, DEMOKRATİKLEŞME VE KATILIMCI SİYASET, TEZKİRE YAY., İSTANBUL, 2015, 233 SAYFA, ISBN:978-605-983-502-2." Social Sciences Studies Journal 4, no. 20 (January 1, 2018): 2614–16. http://dx.doi.org/10.26449/sssj.860.
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Gee, Andrew J., Lisa A. Groen, and Mitchell E. Johnson. "Erratum to: ‘‘Determination of fatty acid amides as trimethylsilyl derivatives by gas chromatography with mass spectrometric detection’’ [J. Chromatogr. 849 (1999) 541–552]." Journal of Chromatography A 859, no. 1 (October 1999): 119. http://dx.doi.org/10.1016/s0021-9673(99)00888-2.
Дисертації з теми "572.869 2":
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Ripp, Caroline. "Analysis of the Wnt receptors Ror, Otk and Otk2 during nervous system development in Drosophila melanogaster." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-869A-2.
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Bonin, Irena [Verfasser]. "Structural analysis of quinoline 2-oxidoreductase from Pseudomonas putida 86 : structural and biochemical studies of two Nus family proteins ; NusB and NusA AR1-λN complex / Irena Bonin". 2005. http://d-nb.info/973922184/34.
Книги з теми "572.869 2":
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Развитие внешнеэкономической деятельности в условиях глобализации. Симферополь: Таврия, 2006.
Частини книг з теми "572.869 2":
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Malisch, Rainer, Peter Fürst, Kateřina Šebková, Daria Sapunova, and Jiří Kalina. "Time Trends in Human Milk Derived from WHO- and UNEP-Coordinated Exposure Studies, Chapter 3: Perfluoroalkyl Substances (PFAS)." In Persistent Organic Pollutants in Human Milk, 543–600. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-34087-1_14.
Анотація:
AbstractTemporal trends of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) were assessed using 86 pooled human milk samples from 59 countries from all United Nations Regional Groups collected between 2008 and 2019 as part of the WHO/UNEP-coordinated exposure studies. The primary objective of these temporal studies is to provide monitoring data for the effectiveness evaluation of the Stockholm Convention on Persistent Organic Pollutants (POPs). General temporal trends were estimated using data from all participating countries by grouping into three equal four-year periods (2008–2011, 2012–2015, and 2016–2019) reflecting the performance of three rounds of the studies. A more precise approach is the use of data from 24 countries with repeated participation in the WHO/UNEP-coordinated exposure studies, 22 of them in different periods and two in the same period. However, there were no Western European countries with multiple participation, and only two countries from the Asia-Pacific Region with one country submitting two samples in the same period.The country-specific PFOS data showed decreasing tendencies in 19 of the 22 countries with participation in different periods, quite constant levels in two countries and increasing tendencies in one country (from its first participation in 2010 to the second participation in 2015). For the two countries with repeated participation in the same period, it does not seem appropriate to derive country-specific temporal tendencies. An overall decrease of PFOS concentrations over 10 years of 48% and 52%, respectively, was calculated by the Theil–Sen method (1) using all samples and (2) using samples from countries with repeated participation. PFOA concentrations showed decreasing tendencies in 17 countries of the 22 countries with participation in different periods, quite constant levels in two countries and increasing tendencies in three countries (from their first participation between 2009 and 2011 to the second participation in 2015). An overall decrease over 10 years for PFOA concentrations of 42% and 47%, respectively, was calculated by the Theil–Sen method (1) using all samples and (2) using samples from countries with repeated participation. The estimation of general temporal trends for PFHxS was not possible, as in 84% of the samples PFHxS concentrations were below the limit of quantification (5.7 ng/L).
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Feather, Leonard, and Ira Gitler. "l." In The Biographical Encyclopedia of Jazz, 395–424. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780195074185.003.0012.
Анотація:
Abstract La porta, john d., cl., saxes, comp, arr; b. Philadelphia, PA, 4/1/20; d. Sarasota, FL, 5/12/04. Began on cl. at age 9. Stud. cl. w. Wm. Dietrich, Joseph Gigliotti, Leon Russianoff 1932–57. Pl. in Youth Symph. cond. by Leopold Stokowski ’37–8. Stud. comp. w. Ernst Toch, Alexis Haieff ’45–6; improv. w. Lennie Tristano ’47–8; received B. Mus. ’56, M. Mus. Ed. ’57 fr. Manh. Sch. of Mus. Pl. w. Bob Chester, Richard Himber, Ray McKinley early ’40s; Woody Herman ’44–6; Tristano late ’40s; Charles Mingus ’50–67; Metronome All-Stars ’51–2; own gps ’51–62. Founding member and mus. dir. of Jazz Composers Wkshp. ’52–4. App. w. Gunther Schuller at Brandeis Mus. Fest. ’57; Leonard Bernstein and N.Y. Philharm. perf. Teo Macero’s Fusion ’58–9. Taught at Parkway Mus. Inst., Bklyn. ’48–51. Reed coach for Marshall Brown’s Newport Youth Band ’53–8. Active as clinician ’59–81. Taught at Manh. Sch. of Mus. ’60–2; Berklee Sch. of Mus. fr. ’62. Dir. Greater Bost. HS Stage Band ’64–5. Pl. w. Bost. Sax Qt. w. Charlie Mariano ’60s; Berklee Sax Qt. fr. ’62; Herb Pomeroy Orch fr. ’76; John La Porta–Bob Winter Duo fr. ’81. La Porta was a founding member of the Nat’l Assoc. of Jazz Educs. and the author of eight instructional texts, incl. Tonal Organization of Improv. Techniques (Kendor); Guide to Improv. (Berklee); Guide to Jazz Phrasing and Interpretation (Berklee). His numerous arrs. for hs band are publ. by Berklee, Kendor, and Marshall Brown Music. La Porta taught and lectured at Berklee and in Fla. Polls: Play. ’61; NAJE Award ’86; Berklee Award ’87. Fests: all major ’50s–’60s. Film: Trocadero w. Bob Chester Orch. perf. La Porta comp. ’42. CDs: w. C. Parker (Verve); T. Macero (Stash); C. Mingus (Deb; Sav.; Atl.); W. Herman (Col.); H. Mobley (Sav.); H. Merrill (Em.; Verve).
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Carr-Hill, Roy Alexander. "Inequalities in Access to and Outcomes of Higher Education in Africa." In Advances in Business Strategy and Competitive Advantage, 150–69. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8169-8.ch007.
Анотація:
There have been very few studies of the socio-economic background and outcomes for students in Africa because of the lack of data. This chapter draws on an institute which has information about their parental background and subsequent careers collected from surveys. In terms of access, the combination of parents not having more than primary education, renting and not owning land identified less than 1% of students whilst the percentage of entrants reporting that their parents had a post-secondary qualification is considerably higher (around 57%) than the norm at the time the parents would have been studying (around 7%). These students were upper middle class. In terms of outcomes, both current students and alumni say that the curriculum only partly fits their employment needs, but 85% of alumni would recommend AIMS to other students. In general, employers are satisfied with AIMS interns, but the percentage of AIMS graduates who are unemployed has risen from 2% in 2011 to 29% in 2016. Finally, rather than contributing to Africa, over one-third of graduates since 2012 are in the West.
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"A Divorce Bill, Possibly Given by a (Jewish) Woman, Shelamzion, to Her Husband, Eleazar." In Women’s Religions in the Greco-Roman World, edited by Ross Shepard Kraemer, 156. Oxford University PressNew York, NY, 2004. http://dx.doi.org/10.1093/oso/9780195170658.003.0065.
Анотація:
Abstract work: One of many papyri found in the Judean desert pertaining to Jewish life around the second century c.e., this particular document has provoked extensive controversy. While some scholars, including Yardeni, consider it the receipt for a divorce document (Hebrew, get), others take it to be a get issued by a woman to her former husband (Milik, Ilan). translation, text, and bibliography: Tal Ilan, “Notes and Observations on a Newly Published Divorce Bill from the Judaean Desert,” HTR 89, no. 2 (1996): 195–202. additional translation, text, and bibliography: Ada Yardeni, Nahfi al Sfie’elim Documents (Jerusalem: Israel Exploration Society and Ben Gurion University in the Negev Press, 1995). additional bibliography: David Instone Brewer, “Jewish Women Divorcing Their Husbands in Early Judaism: The Background to Papyrus Sfie’elim 13,” HTR 92, no. 3 (1999): 349–57; J. T. Milik, “Le travail d’édition des manuscrits du désert de Juda,” Volume du congres Strasbourg 1956, Supplements to Vetus Testamentum 4 (Leiden: E. J. Brill, 1956), 17–26; Michael Satlow, Jewish Marriage in Antiquity (Princeton: Princeton University Press, 2001); A. Schremer, “Divorce in Papyrus Sfie’elim Once Again: A Reply to Tal Ilan,” HTR 91, no. 2 (1998): 193–204 (with response from Ilan).
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Taber, Douglass F. "Heteroaromatic Construction: The Wipf Synthesis of Cycloclavine." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0068.
Анотація:
Wesley J. Moran of the University of Huddersfield cyclized (Tetrahedron Lett. 2011, 52, 2605) a propargylated ketone 1 with Au to give the furan 2. Shengming Ma of the Shanghai Institute of Organic Chemistry found (Synlett 2011, 931) that tri(2-furyl)phosphine catalyzed the rearrangement of cyclopropene diesters, prepared by the addition of diazomalonate to alkynes, to the corresponding alkoxy furan 4. Xihe Bi and Qian Zhang of Northeast Normal University established (Chem. Commun. 2011, 47, 809) that a simple Fe catalyst effected the condensation of 5 with 6 to give the pyrrole 7. Gianfranco Favi of the Università degli Studi di Urbino showed (J. Org. Chem. 2011, 76, 2860) that the three-component coupling of 8 with an amine 9 and a ketone 10 proceeded without catalyst to deliver the pyrrole 11. Timothy J. Donohoe of the University of Oxford homologated (Org. Lett. 2011, 13, 1036) 12 by cross-metathesis with methyl vinyl ketone, to give, after oxidation and condensation with NH4OAc, the substituted pyridine 13. Dale L. Boger of Scripps/La Jolla condensed ( Org. Lett. 2011, 13, 2492) the unsubstitued 1,2,3-triazine 15 with an enamine 14 to give 16. Shunsuke Chiba of Nanyang Technological University prepared (J. Am. Chem. Soc. 2011, 133, 6411) the pyridine 19 by oxidizing the cyclopropanol 17 in the presence of the alkenyl azide 18. Limin Wang of the East China University of Science and Technology prepared (Tetrahedron Lett. 2011, 52, 509) the 2-aminopyridine 23 by the four-component coupling of the aldehyde 20 and the ketone 22 with NH4OAc and malononitrile 21. Taking advantage of the Knochel protocol for aryl Grignard formation, Christopher J. Moody of the University of Nottingham combined (Chem. Commun. 2011, 47, 788) the adduct from 24 with the ketone 25 to give the indole 26. Carsten Bolm of RWTH Aachen extended (Org. Lett. 2011, 13, 2012) the Fe catalysis reported by Zheng to the azide 27 to give 28. Sang-gi Lee of Ewha Womans University found (Org. Lett. 2011, 13, 1350) that the Blaise adduct from the addition of 29 to the nitrile could be cyclized to the indole 30.
6
Scott, Andrew, Morten Hviid, Bruce Lyons, and Christopher Bright. "Relationship With The Ec Merger Control Regime." In Merger Control in the united kingdom, 65–86. Oxford University PressOxford, 2006. http://dx.doi.org/10.1093/oso/9780199276882.003.0005.
Анотація:
Abstract The EC regime provides for the review of ‘concentrations’. A concentration is deemed to arise on a ‘change of control on a lasting basis’, with ‘control’ being understood as ‘the possibility of exercising decisive influence on an undertaking’: Council Regulation (EC) No 139/2004 on the control of concentrations between undertakings (2004) OJ L24/1 (hereinafter ‘ECMR’ or ‘Merger Regulation’), Article 3. See also, Commission Notice on the concept of concentration under Council Regulation (EEC) No 4064/89 on the control of concentrations between under- takings [1998] OJ C66/2. By virtue of Article 57 of the European Economic Area Agreement, the Commission also exercises jurisdiction over concentrations with a Community dimension across the EFTA territory (includes the EC and Iceland, Liechtenstein and Norway, but bars Switzerland for these purposes). The EFTA Surveillance Authority has jurisdiction over concentrations that do not come within the Commission ‘s jurisdiction, but which meet the turnover thresholds in the EFTA territory.
7
Feldman-Winter, Lori, Kinga Szucs, Aubri Milano, Elizabeth Gottschlich, Blake Sisk, and Richard J. Schanler. "National Trends in Pediatricians’ Practices and Attitudes About Breastfeeding: 1995 to 2014." In Breastfeeding: Support, Challenges, and Benefits, 39–47. American Academy of Pediatrics, 2018. http://dx.doi.org/10.1542/9781610022873-national_trends.
Анотація:
BACKGROUND AND OBJECTIVES The American Academy of Pediatrics (AAP) has affirmed breastfeeding as the preferred method of infant feeding; however, there has been little systematic examination of how pediatricians’ recommendations, affiliated hospitals’ policies, counseling practices, and attitudes toward breastfeeding have shifted over the past 2 decades. These trends were examined from 1995 to 2014. METHODS Data are from the Periodic Survey (PS) of Fellows, a nationally representative survey of AAP members. PS #30 (1995; response rate = 72%; N = 832), PS #57 (2004; response rate = 55%; N = 675), and PS #89 (2014; response rate = 51%; N = 620) collected demographics, patient and practice characteristics, and detailed responses on pediatricians’ recommendations, affiliated hospitals’ policies, counseling practices, and attitudes toward breastfeeding. By using bivariate statistics and logistic regression models, the analysis investigated changes over time with predicted values (PVs). RESULTS From 1995 to 2014, more pediatricians reported their affiliated hospitals applied for “baby-friendly” designation (PV = 12% in 1995, PV = 56% in 2014; P < .05), and more reported that they recommend exclusive breastfeeding (65% to 76% [P < .05]). However, fewer respondents indicated that mothers can be successful breastfeeding (PV = 70% in 1995, PV = 57% in 2014; P < .05) and that the benefits outweigh the difficulties (PV = 70% in 1995, PV = 50% in 2014; P < .05). Younger pediatricians were less confident than older pediatricians in managing breastfeeding problems (P < .01). CONCLUSIONS Pediatricians’ recommendations and practices became more closely aligned with AAP policy from 1995 to 2014; however, their attitudes about the likelihood of breastfeeding success have worsened. These 2 divergent trends indicate that even as breastfeeding rates continue to rise, continued efforts to enhance pediatricians’ training and attitudes about breastfeeding are necessary.
8
Santos, M., and E. Guilherme. "COMUNIDADE DE AVES E A INTERAÇÃO AVE-PLANTA EM UM ENCLAVE DE CAMPINARANA NO SUDOESTE DA AMAZÔNIA." In Conservação e Biodiversidade Amazônica: potencialidade e incertezas - Volume 2, 28–47. Editora Científica Digital, 2022. http://dx.doi.org/10.37885/220809675.
Анотація:
O presente estudo teve como objetivo investigar a dispersão de sementes por aves frugívoras em um ecossistema de campinarana no sudoeste da Amazônia. Realizamos o estudo em um enclave de campinarana localizado no oeste do estado do Acre, em uma das trilhas permanentes ao Programa de Pesquisa em Biodiversidade (PPBio/Acre), com três fitofisionomias predominantes: campinarana arbórea (CA); campinarana arbustiva (CAR) e campinarana florestada (CF). Utilizamos 10 redes de neblina para a captura das aves no período de abril a setembro de 2019. Capturamos 396 indivíduos de 49 espécies de aves, distribuídas em 14 Famílias e três Ordens. Na CA foram capturados 131 indivíduos (33,1%), na CAR 175 (44,1%) e na CF 90 (22,7%). Dos 396 indivíduos capturados, 172 (60,3%) forneceram material fecal e, em 89 (52%) havia sementes. Coletamos 921 sementes a partir do material fecal das aves, classificadas em 54 táxons botânicos, destes, cinco foram identificadas a nível de espécie e 49 a nível de gênero, pertencentes a 19 famílias botânicas. As espécies Xenopipo atronitens (CA e CAR) e Ceratopipra rubrocapilla (CF) apresentaram o maior índice de importância na dispersão de sementes entre todas as aves capturadas. A análise de similaridade indicou que cada fitofisionomia possui uma comunidade de aves diferentes entre si ao longo do transecto amostrado. A dispersão de sementes foi predominantemente realizada por espécies de aves da família Pipridae e a dissimilaridade entre a comunidade de aves de sub-bosque dentro do enclave pode ser atribuída a variação estrutural e florística de cada fitofisionomia.
9
Li, Jie Jack, Chris Limberakis, and Derek A. Pflum. "Functional Group Manipulations." In Modern Organic Synthesis in the Laboratory. Oxford University Press, 2008. http://dx.doi.org/10.1093/oso/9780195187984.003.0008.
Анотація:
CBr4–Ph3P is very straightforward and widely used. Workup and purification can be messy at times because of the by-product, Ph3PO. To a mixture of the alcohol (0.800 g, 3.36 mmol) and carbon tetrabromide (1.337 g, 4.03 mmol) in CH2Cl2 at 0 ºC was added a solution of PPh3 (1.319 g, 5.03 mmol) in CH2Cl2 (3 mL). The reaction mixture was stirred at room temperature for 1 h, concentrated under reduced pressure, and purified by column chromatography to afford the bromide (0.941 g, 93% yield). Reference: Hu, T.-S.; Yu, Q.; Wu, Y.-L.; Wu, Y. J. Org. Chem. 2001, 66, 853–861. A two-step sequence consisting of mesylate formation followed by treatment with LiBr can also be used. This procedure involves two steps, but workup and purification are very straightforward. The bromide can be carried out to the next step without further purification in many cases. To a solution of 5-hydroxymethyl-1-methylcyclopentene (3.8 g, 34 mmol) in CH2 Cl2 (50 mL) at 0 ºC was added triethylamine (5.2 mL, 37 mmol) followed by methanesulfonyl chloride (2.9 mL, 37 mmol). The mixture was stirred at 0 ºC for 5 h and then water was added. The organic layer was separated and the aqueous layer was extracted with ether. The combined organic extracts were dried over MgSO4 and the solvent was removed under reduced pressure to give 6.4 g (98%) of (2-methylcyclopent-2- enyl)methyl methanesulfonate, which was used in the next step without further purification. A solution containing the mesylate (6.4 g, 34 mmol) in acetone (70 mL) was treated with lithium bromide (8.89 g, 102 mmol). The mixture was heated at reflux for 6 h, cooled to room temperature, diluted with water, extracted with ether, and the combined ethereal extracts were dried over MgSO4. Removal of the solvent under reduced pressure gave 4.6 g (78%) of 5-bromomethyl-1-methylcyclopentene, which was used in the next step without further purification.
10
Ali, Anwar, Quratul Ain, Ayesha Saeed, Waseem Khalid, Munir Ahmed, and Ahmed Bostani. "Bio-Molecular Characteristics of Whey Proteins with Relation to Inflammation." In Whey Proteins - Uses and Biological Roles [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99220.
Анотація:
Whey proteins in bovine milk are a mixture of globular proteins manufactured from whey which is a byproduct of cheese industry. Whey protein is categorized to contain plethora of healthy components due to wide range of pH, promising nutritional profile with cost effective and diverse functionality. Reportedly there are three categories of whey protein, whey protein concentrate (WPC) (29–89%); whey protein isolate (WPI) 90% and whey protein hydrolysate (WPH) on the basis of proteins present in them. Whey proteins is composed of β-lactoglobulin (45–57%), immunoglobulins (10–15%) α-lactalbumin (15–25%), glicomacropeptide (10–15%), lactoperoxidase (<1%) and lactoferrin nearly (1%). Whey protein plays an important role and is validated to confer anti-inflammatory and immunostimulatory roles related to all metabolic syndromes. According to molecular point of view whey proteins decrease inflammatory cytokines (IL-1α, IL-1β, IL-10 and TNF- α); inhibits ACE and NF-κB expression; promotes Fas signaling and caspase-3 expression; elevates GLP-1, PYY, CCK, G1P and leptin; chelate and binds Fe+3, Mn+3 and Zn+2. In this chapter we will discuss significant biological role of whey proteins related to inflammatory health issues.
Тези доповідей конференцій з теми "572.869 2":
1
Jones, D., L. Darwin, K. Wilson, S. Kisting, JM Spiegel, P. Adu, and A. Yassi. "861 Successfully implementing information systems to improve occupational health and safety performance – 2: case studies." In 32nd Triennial Congress of the International Commission on Occupational Health (ICOH), Dublin, Ireland, 29th April to 4th May 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/oemed-2018-icohabstracts.522.
2
Yardley, D., M. Seiler, I. Ray-Coquard, B. Melichar, L. Hart, V. Dieras, M. Barve, et al. "Ridaforolimus (AP23573; MK-8669) in Combination with Trastuzumab for Patients with HER2-Positive Trastuzumab-Refractory Metastatic Breast Cancer: A Multicenter Phase 2 Clinical Trial." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-3091.
3
Cohn, Marvin J., Michael T. Cronin, Fatma G. Faham, David A. Bosko, and Erick Liebl. "Optimization of NDE Reexamination Locations and Intervals for Grade 91 Piping System Girth Welds." In ASME 2015 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/pvp2015-45630.
Анотація:
It has become apparent with the development of creep strength enhanced ferritic steels, the mandatory ASME B31.1 Chapter VII and the non-mandatory ASME B31.1 Appendix V guidelines require a more rigorous method to manage the Grade 91 piping integrity at Genesee Unit 3. Given the relatively young age of Genesee Unit 3, three questions have been asked: 1) when do the examinations start, 2) what locations should be examined first, and 3) how often should the same location be reexamined? To ensure that the best value is obtained from the reexamination budget, a five-step process can be effectively used to define and categorize the scope of each set of reexaminations in the girth weld integrity management program. The five processes are performing the following analyses: 1) an evaluation of the historical information, 2) piping system hot and cold walkdowns, 3) as-designed and as-found piping stress analyses, 4) creep life consumption evaluations, including elastic and inelastic axial and radial stress redistributions, and 5) creep crack growth curve analyses. Reexaminations of the few critical lead-the-fleet weldments are performed with lower examination costs and higher confidence. Evaluations of the Genesee Unit 3 main steam (MS) piping system revealed that the applicable weldment stress is probably the most significant parameter in determining the Grade 91 girth weld critical reexamination locations and intervals. ASME B31.1 piping stress analyses of the MS piping system have sustained load stress variations of more than 100% among the girth welds. The lower bound American Petroleum Institute (API) 579 creep rupture equation for Grade 91 operating at 1,060°F (571°C) indicates that the creep life is a function of stress to the power of 8.9; consequently, a 15% stress increase results in about 2/3 reduction of creep rupture life. Creep crack growth analyses of several of the MS piping system weldments revealed that the creep crack growth time to grow from 1/8 inch to through-wall is a function of stress to the power of 8.8; consequently, a 15% stress increase results in about 2/3 reduction of time for a 1/8-inch crack to grow through-wall. This evaluation reveals that a few critical lead-the-fleet locations should be reexamined most frequently and justification can be provided for much longer reexamination intervals of the remaining girth welds with much lower applied stresses.
4
Filipović, S., and N. Radulović. "ESSENTIAL OIL ANALYSIS OF THE „MICROMERIA JULIANA“ (L.) BENTH., FROM LUŠTICA, MONTENEGRO." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.332f.
Анотація:
Micromeria (Bentham, 1829.) is a polymorph genus of Lamiaceae with about 130 species grouped in three sections: Cymularia, Eumicromeria and Pseudomelissa, the most diverse in Mediterranean regions, but widespread across Europe, Asia, Africa, and North America [1]. Up to now, eight Micromeria species have been recorded inhabiting the territory of Montenegro including a dwarf shrub, Micromeria juliana (L.) Benth. Knowing the existence of the variability in quantity and qualitative makeup, interpopulational, and the interspecies variability of the up to now reported essential oils from this plant prompted us to make the detailed analysis of the M. juliana specimens originating from rocky, sunny carbonate rock bases in Zabrđe, Montenegro, since the plant material from this area was not examined before. Detailed GC-MS analysis of the obtained essential oil resulted in 70 identified components among which α-pinene (12.2%), (E)-nerolidol (8.9%), viridiflorol (6.8%), limonene (6.1%), and borneol (5.2%) prevailed, differing significantly in content from the previously reported populations (Morača canyon, Cijevna canyon, Mt. Orjen and Mt. Krivošije) [2]. The objective of this study is to gain insight into the essential oil structure, determine the possible mutual similarity and the variability in their chemical compositions, and to enclose possible diversity in the secondary metabolite profile dependent on the site of collection.
5
McLeod, B., R. Sassetti, E. Cole, and P. Scott. "LONG TERM, FREQUENT PLASMA EXCHANGE DONATION OF CRYOPRECIPITATE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644024.
Анотація:
In plasma exchange donation (PED), several liters of fresh plasma are removed fran a donor with a pheresis instrument as a source of cryoprecipitate, and replaced with autologous cryoprecipitate-supernatant from the previous donation. Repetitive PED can produce large quantities of factor VIII from individual donors over time, with a favorable impact on donor exposure for factor VIII recipients. To clarify the implications for donor safety, we report our experience with several donors who have undergone multiple PEDs. Detailed observations are presented for one donor who has undergone PED 101 times between 5/83 and 1/87, and has provided all the factor VIII needed by his son (now age 14) with severe hemophilia A during this period. Exchange volume was gradually increased while donation frequency was gradually decreased. There were 23 exchanges of 2 L, 52 of 2.5 L, and 26 of 3 L for a total of 254 L plasma exchanged. Desmopressin (20 meg tV) was given before 45 more recent donations to augment factor VIII yield. A total of 343,274 IU factor VIII have been collected; the mean (±SD) yield from a 3 L, desmopressin- stimulated PED is 5598 ± 899 IU. The donor has remained in good health; he has noted no adverse effects fran any PED, and none have been found in laboratory monitoring. Prior to the 100th donation the following were within normal limits: CBC,platelet count, urinalysis, SMA-18, protein electrophoresis, IgG, IgA, IgM, hemolytic complement, C3, C4, fibronectin, prothrombin time, partial thromboplastin time, thranbin time, factor VIII:C (140%), factor VIII:Ag (134%), von Willebrand factor (86%) and fibrinogen (215 mg/dL). In another family, the father has donated 40 times since 1981 and the paternal grandmother has donated 31 times since 1984 with no untoward effects detected in clinical or laboratory monitoring. They have supported two moderately affected patients now ages 7 and 9. Extensive experience with these donors suggests that repeated PED is safe, and that a highly motivated donor can sometimes provide single donor support, even for a severe hemophiliac.
6
Bitencourt, Tamires Cristine, Caio Henrique Veloso da Costa, Ana Lucia de Carvalho Mello, Saulo Ramos Ribeiro, and Renan Barros Domingues. "Correlation between neurological deficit at admission and functionality at discharge of patients from a clinical hospital stroke program." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.593.
Анотація:
Introduction: Stoke is one of the main causes of disability in Brazil, with an average hospital stay (HS) of 11 days and prolonged HS can generate functional impairment to patients. Objectives: To correlate neurological deficit at admission with functionality and days of HS. Methods: Patients were selected from the clinical program of post-stroke care, from March to December 2022 with HS time greater than or equal to 4 days. They were divided into 2 groups: Group 1, between 4 and 11 days of HS and group 2, greater than 11 days of HS. The Functional Independence Measure (FIM) and the National Institute of Health Stroke Scale (NIHSS) were applied at admission and discharge. Data analysis was performed with Microsoft Excel© 2016 with descriptive statistics, Pearson’s Correlation Test was also performed, considering P < 0.05 for the variables studied. Results: 86 subjects were included. 41 were excluded due to lack of informations in medical records, and 45 patients were analyzed. Group 1: Included 32 patients, 24 with ischemic stroke (IS), 2 hemorrhagic stroke (ICH) and 6 transient ischemic attack (TIA), 56.2% were female and 69 ± 15.2 years and 5.9 ± 15.9 days HS with 5.2 ± 4.8 points in the FIM/days of hospitalization and NIHSS admission of 2.9 ± 4.2. Group 2: 13 patients, 11 with IS, 2 ICH, 61.5% male, with 67±15.2 years, NIHSS admission of 7.3 ± 4.2, there was a gain of 1.14 ± 4.7 points in the FIM/days of hospitalization and 21.3 ± 15.7 days HS. There was a negative correlation between Days of Hospitalization and FIM/days of hospitalization (r = -0.3), Days of Hospitalization and FIM at Discharge (r = -0.57) and NIHSS admission and FIM of discharge (r = -0.6). Conclusion: We observed a correlation between neurological deficit at admission, functional outcome at discharge and time of HS related to systematized assistance to a clinical stroke program.
7
Валиахметов, Э. Э., Д. М. Афордоаньи та Ш. З. Валидов. "Сочетание генетических и фенотипических методов для эффективной дифференциации изолятов растений". У III молодежная всероссийская научная конференция с международным участием «PLANTAE & FUNGI». Botanical Garden-Institute FEB RAS, 2023. http://dx.doi.org/10.17581/paf2023.04.
Анотація:
Эффективные биопрепараты для защиты и стимуляции растений являются важной составляющей повышения продуктивности растениеводства и безопасности получаемой продукции. Исследование качественного и количественного состава микробиома сельскохозяйственных культур позволит создать более эффективные биопрепараты на основе устойчивых консорциумов. Анализ состава микробиома, как и поиск новых перспективных штаммов, главным образом сводится к решению трех задач: выделение микроорганизмов, их идентификации и выявлению полезных свойств. Зачастую, одна проба может содержать несколько изолятов одного и того же вида, а наиболее представленные штаммы присутствуют в количестве большем, чем остальные микроорганизмы. Нами был применен комбинированный подход к дифференциации бактериальных изолятов, включающий в себя ПЦР-фингерпринтинг (BOX-PCR) и последующим анализом с помощью программы GelJ [1] в сочетании с фенотипическим анализом ферментативных активностей изолятов (амилазной, целлюлазной, липазной, протеазной и хитиназной), Интересующие уникальные штаммы затем идентифицируются методом секвенирования гена 16S рРНК, что также позволяет выявить условно патогенные штаммы и исключить их из дальнейшей работы. Наибольшую эффективность данный подход демонстрирует при анализе микробиома надземной части растений, которая имеет относительно низкое видовое разнообразие [2]. Рассмотрим его применение на примере определения бактериального консорциума филлопланы озимой пшеницы на стадиях трубкования и восковой спелости. При анализе изоляты со стадии трубкования были сгруппированы в 3 крупных кластера, включающих в себя 57, 18 и 10 штаммов; один малый кластер, включающий 2 штамма, были также обнаружены 2 уникальных штамма. Изоляты стадии восковой спелости формировали 4 кластера включающих 50, 4, 4 и 2 штамма соответственно, а также один уникальный штамм. Проведение ПЦР-фингерпринтинга и кластерного анализа в сочетании с данными ферментативных активностей позволило значительно сократить количество изучаемых изолятов без потери их разнообразия. Такой подход позволил исключить секвенирование 83,9% клонов (73 из 83) для стадии трубкования и 86,9% клонов (53 из 61) для стадии восковой спелости, поскольку данные изоляты были клонами одних и тех же штаммов. Тем самым, удалось значительно сократить объем работы и затраты на исследование, не теряя полноты получаемых данных.
8
Ременюк, И. В. "ДИАГНОСТИЧЕСКАЯ ЗНАЧИМОСТЬ ЭЛЕКТРОНЕЙРОМИОГРАФИИ (ЭНМГ) ДЛЯ ВЕРИФИКАЦИИ И ДИНАМИКИ ПРОГРЕССИРОВАНИЯ СУБКЛИНИЧЕСКОЙ ДИАБЕТИЧЕСКОЙ ПОЛИНЕЙРОПАТИИ (ДПН)". У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-89.
Анотація:
ЦЕЛЬ: обосновать необходимость проведения ЭНМГ по сенсорным нервным волокнам для ранней
диагностики и оценки прогрессирования ДПН в доклинической стадии.
МАТЕРИАЛЫ И МЕТОДЫ: в исследование было включено 57 пациентов с сахарным диабетом (СД)
с бессимптомной ДПН, из них с СД 1 типа (n=36),средний возраст – 33,1 ± 10,3 лет, средняя длительность
заболевания – 6,7 ± 2,3 лет, средний уровень гликированного гемоглобина (НВА1С) – 8,9 ± 2,01 %, с СД
2 типа (n=21), средний возраст – 51,7 ± 7,3 лет, средняя длительность заболевания - 3,9 ± 1,1 лет, средний
уровень НВА1С – 8,7 ± 2,2 %. Выраженность ДПН оценивали по степени проявления симптомов и клини-
ческого неврологического обследования с помощью шкалы Нейропатического Симптоматического Счёта
(НСС), где учитывались жалобы на покалывание, жжение, онемение, ноющую боль, судороги, гиперестезию,
отсутствие жалобы расценивалось, как «0» баллов, наличие – 1 балл, усиление в ночное время – 2 бал-
ла, максимальная сумма баллов по данной шкале -18; шкалы Модифицированного Нейропатического
Дисфункционального Счёта (НДСм), предложенной центром «Диабетическая стопа» г. Москва, по которой
исследуется чувствительность на уровне тыльной поверхности большого пальца. Тактильную чувствитель-
ность исследовали 10гр монофиламентом Thio – Feel, производства Германия, порог болевой чувстви-
тельности при помощи ручки Neuropen, температурную чувствительность прибором Thip – term, порог
вибрационной чувствительности градуированным камертоном Rydel – Seiffer 128 Гц. ЭНМГ по сенсорным
нервным волокнам проводилась на аппарате ,,Нейрон – Спектр – СМ,, производства Россия с исследо-
ванием амплитуды М – ответа, скорости распространения возбуждения (СРВ) по n. Peroneus superficialis,
n.Suralis, n.Saphenus.
РЕЗУЛЬТАТЫ: у всех пациентов с СД 1 и 2 типов уровень НВА1С был сопоставим. Стаж СД у пациентов
со 2 типом был меньше, так как, согласно клиническим рекомендациям, обследование для диагностики
ДПН, проводится от дебюта заболевания. У всех пациентов по шкалам НСС и НДСм, сумма баллов составила
«0». Для верификации субклинической ДПН проведена ЭНМГ по сенсорным нервным волокнам. У 22% па-
циентов с 1 типом СД зарегистрировано снижение амплитуды по одному нерву (n.Saphenus), у 22% отсут-
ствие изменений по ЭНМГ, у 50% выявлены изменения более, чем по двум нервам, в основном снижение
амплитуды М-ответа; у 20% с подтверждённой ДПН, в динамике отмечался регресс показателей ЭНМГ.
У 14% с диабетом 2 типа зарегистрировано снижение амплитуды по одному нерву (n.Saphenus), у 29% от-
сутствие изменений по ЭНМГ, у 57% выявлены изменения более, чем по двум нервам со снижением, как
амплитуды М-ответа, так и СРВ.
ВЫВОДЫ: ЭНМГ по сенсорным нервным волокнам позволяет подтвердить, либо исключить наличие
у пациентов с субклинической ДПН, а также при сохраняющихся с увеличением стажа заболевания без
изменения показателей по шкалам НСС и НДСм, оценить динамику прогрессирования неврологических
изменений по данным амплитуды М-ответа и СРВ.
9
Félix, Jaqueline, João Refundini, Maria Carthery Goulart, Katerina Lukasova, and Raquel Fornari. "DEVELOPMENT OF A TOOL TO EVALUATE FACE-NAME LEARNING IN PORTUGUESE SPEAKERS." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda096.
Анотація:
Background: Learning and retrieving proper names is one of the most common complaints among older adults. However, this aspect is not commonly assessed in this population. Objective: To develop an anterograde episodic memory assessment tool that measures the ability to learn, retain and retrieve face-name associations and test its application. Methods: The face-name association (FNAT) has 2 versions (A and B) and involves learning, free recall and recognition of 12 pairs. FNAT was applied to 86 community dwelling older adults, aged 69(±6), schooling 13(±3). (64 did version A, 57 B and 35 AB). Second test (AB) occurred 2-3 months after the first. Results: In both versions, recognition scores were higher than learning and free recall respectively (version A 47±24%, 34±25%, 76±20%; version B 51±26%, 41±26%, 74±24%). In the subgroup that performed both versions, no significant differences were found between the three subtests. Conclusion: FNAT was applied successfully in our sample. Test and retest effects were not observed and the two versions demonstrated an equivalent level of difficulty. Further studies are needed to explore cutoff scores according to aging and education.
10
Демяненко, А. Н. "ОСОБЕННОСТИ FLASH-МОНИТОРИНГА ГЛИКЕМИИ У ДЕТЕЙ ШКОЛЬНОГО ВОЗРАСТА С САХАРНЫМ ДИАБЕТОМ 1 ТИПА С ИЗБЫТОЧНОЙ МАССОЙ ТЕЛА И ПРОСТЫМ ОЖИРЕНИЕМ". У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-286.
Анотація:
бетом 1 типа (СД1) с избыточной массой тела и ожирением.
МАТЕРИАЛЫ И МЕТОДЫ: проведен анализ показателей Flash-мониторинга гликемии у детей 7-17 лет
с сахарным диабетом 1 типа по данным отчетов LibreView. Анализ показателей углеводного обмена оценивали у пациентов с временем активности датчика FreeStyle Libre > 70%. Пациенты были распределены
на 2 группы: 1-я – дети с СД1 с ожирением и избытком массы тела (n=31), 2-я – дети с СД1 и нормальной
массой тела (n=69). Статистическая обработка результатов проводилась с помощью программы Statistic
7,0 (StatSoft, 2009), Excel 10.0.
РЕЗУЛЬТАТЫ: пациенты обеих групп были сопоставимы были сопоставимы (р>0,05) по возрасту
(11,5 лет [10,0-13,0] и 12,0 лет [10,0-15,0]), полу, длительности сахарного диабета (4,0 года [2,0-6,3] и 5,0 лет
[3,5-7,0] соответственно) и уровню гликированного гемоглобина (HbA1c) на момент обследования (8,9%
[8,1-9,9] и 8,5% [7,3-9,0]). Все пациенты находились на многократных инъекциях инсулина и использовали
Flash-мониторинг гликемии в течение 6-9 месяцев.
При сравнении показателей Flash-мониторинга было установлено, что в целевом диапазоне находились 4 (13%) пациента 1-й группы и 18 (26%) пациентов 2-й группы (р>0,05). Показатели гликемии выше
целевых значений чаще регистрировались у пациентов 1-й группы – 27 (87%) в сравнении с пациентами
2-й группы (40 (58%), р=0,005).
Показатели гликемии ниже целевого диапазона с одинаковой частотой регистрировались у пациентов
обоих групп (14 (45%) и 26 (38%) соответственно, р>0,05). Между тем, у пациентов с ожирением и избытком
массы тела отмечалась тенденция к более частым гипогликемиям (12 [5-15]) в сравнении с пациентами
2-й группы (9 [4-13], р=0,062), однако длительность гипогликемии была при этом была ниже (67 мин [64-105]
и 83 мин [57-122] соответственно, р=0,047).
Нормальная вариабельность гликемии чаще регистрировалась у пациентов 1-й группы (5 (16%)) в сравнении с пациентами 2-й группы (25 (36%), р=0,058).
Целевых показателей HbA1c (DCCT) < 7,0% у пациентов 1-й группы не отмечалось, тогда как целевой
HbA1c был достигнут у 18 (26%) пациентов 2-й группы (р=0,041).
ВЫВОДЫ: при оценке показателей углеводного обмена у детей с сахарным диабетом 1 типа с избыточной массой тела и ожирением чаще выявляется высокая вариабельность и показатели гликемии выше
целевых значений, отмечается тенденция к болеем частым гипогликемиям при меньшей их длительности.
Пациенты с сахарным диабетом 1 типа с избытком массы тела и ожирением реже достигают целых значений
гликированного гемоглобина.
Звіти організацій з теми "572.869 2":
1
Chou, Roger, Azrah Y. Ahmed, Benjamin J. Morasco, Christina Bougatsos, Tracy Dana, Rongwei Fu, and Terran Gilbreath. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2023 Update. Agency for Healthcare Research and Quality, August 2023. http://dx.doi.org/10.23970/ahrqepccer250update2023.
Анотація:
Objectives. To update the evidence on benefits and harms of cannabinoids and other plant-based compounds to treat sub-acute and chronic pain in adults and adolescents using a living systematic review approach. Data sources. Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Library, and SCOPUS® databases; and reference lists of included studies were searched to April 23, 2023. Review methods. An updated protocol with expanded inclusion criteria (addition of sub-acute [4 to 12 weeks’ duration] pain and adolescents) was posted on the PROSPERO registry. We grouped studies based on their THC to CBD ratio and by product type, i.e. whole-plant (extracted or purified), or synthetic. We conducted random effects meta-analyses and categorized magnitude of benefit (large, moderate, small, or no effect [less than small]). Results. Two new RCTs (n=115 and 15) and two new observational studies (N=2,071) were added for this annual update; no study addressed subacute pain or adolescents. One new RCT compared high and low THC to CBD ratio products versus placebo; the other new RCT evaluated was very small and had methodological limitations. Since the inception of this living review, from 5,228 total abstracts identified, 23 RCTs (N=2,035) and 10 observational studies (N=15,840) assessing different cannabinoids were included; no study evaluated kratom. Studies were primarily short term, and 58 percent enrolled patients with neuropathic pain. Comparators were primarily placebo or usual care. Strength of evidence was low, unless indicated otherwise. Compared with placebo, plant-extracted, comparable ratio THC to CBD oral spray was associated with a small decrease in pain severity (7 RCTs, N=632, 0 to 10 scale, mean difference [MD] −0.54, 95% confidence interval [CI] −0.95 to −0.19, I2=39%; SOE: moderate) and overall function (6 RCTs, N=616, 0 to 10 scale, MD −0.42, 95% CI −0.73 to −0.16, I2=32%; SOE: moderate) versus placebo. There was no effect on study withdrawals due to adverse events. There was a large increased risk of dizziness and sedation, and a moderate increased risk of nausea (dizziness: 6 RCTs, N=866, 31.0% vs. 8.0%, relative risk [RR] 3.57, 95% CI 2.42 to 5.60, I2=0%; sedation: 6 RCTs, N=866, 8.0% vs. 1.2%, RR 5.04, 95% CI 2.10 to 11.89, I2=0%; and nausea: 6 RCTs, N=866, 13% vs. 7.5%, RR 1.79, 95% CI 1.19 to 2.77, I2=0%). Synthetic high-THC to CBD ratio products were associated with a small improvement in pain severity, a moderate increase in sedation, and a large increase in risk of nausea following the addition of one new RCT (pain: 7 RCTs, N=448, 0 to 10 scale, MD −0.95, 95% CI −1.81 to −0.25, I2=60%; sedation: 4 RCTs, N=386, 19% vs. 12%, RR 1.60, 95% CI 1.01 to 2.95, I2=8%; nausea: 3 RCTs, N=353, 11.1% vs. 5.2%, RR 2.22, 95% CI 0.90 to 5.05; I²=0%). There was also moderate SOE for a large increased risk of dizziness (3 RCTs, N=353, 29% vs. 11%, RR 2.52, 95% CI 1.20 to 4.82, I2=41%). Extracted whole-plant high-THC to CBD ratio products (oral) were associated with a large increased risk of study withdrawal due to adverse events (1 RCT, viii 13.9% vs. 5.7%, RR 3.12, 95% CI 1.54 to 6.33) and dizziness (1 RCT, 62.2% vs. 7.5%, RR 8.34, 95% CI 4.53 to 15.34); outcomes assessing benefit were not reported or insufficient. Evidence (including observational studies) on whole-plant cannabis, topical or oral CBD, low-THC to CBD products (2 new RCTs), other cannabinoids, comparisons with active non-cannabis treatments or between cannabis-related products, and impact on use of opioids also remained insufficient. Evidence was not available on important harms such as psychosis, cannabis use disorder, and cognitive effects. Conclusions. Low to moderate strength evidence suggests small improvements in pain (mostly neuropathic), and moderate to large increases in common adverse events (dizziness, sedation, nausea) with high and comparable THC to CBD ratio extracted cannabinoids and synthetic products versus placebo during short-term treatment (1 to 6 months) in adults with chronic pain. Evidence for low-THC to CBD ratio products, whole-plant cannabis, and other comparisons, outcomes, and plant-based compounds was unavailable or insufficient to draw conclusions.
2
Newman-Toker, David E., Susan M. Peterson, Shervin Badihian, Ahmed Hassoon, Najlla Nassery, Donna Parizadeh, Lisa M. Wilson, et al. Diagnostic Errors in the Emergency Department: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), December 2022. http://dx.doi.org/10.23970/ahrqepccer258.
Анотація:
Objectives. Diagnostic errors are a known patient safety concern across all clinical settings, including the emergency department (ED). We conducted a systematic review to determine the most frequent diseases and clinical presentations associated with diagnostic errors (and resulting harms) in the ED, measure error and harm frequency, as well as assess causal factors. Methods. We searched PubMed®, Cumulative Index to Nursing and Allied Health Literature (CINAHL®), and Embase® from January 2000 through September 2021. We included research studies and targeted grey literature reporting diagnostic errors or misdiagnosis-related harms in EDs in the United States or other developed countries with ED care deemed comparable by a technical expert panel. We applied standard definitions for diagnostic errors, misdiagnosis-related harms (adverse events), and serious harms (permanent disability or death). Preventability was determined by original study authors or differences in harms across groups. Two reviewers independently screened search results for eligibility; serially extracted data regarding common diseases, error/harm rates, and causes/risk factors; and independently assessed risk of bias of included studies. We synthesized results for each question and extrapolated U.S. estimates. We present 95 percent confidence intervals (CIs) or plausible range (PR) bounds, as appropriate. Results. We identified 19,127 citations and included 279 studies. The top 15 clinical conditions associated with serious misdiagnosis-related harms (accounting for 68% [95% CI 66 to 71] of serious harms) were (1) stroke, (2) myocardial infarction, (3) aortic aneurysm and dissection, (4) spinal cord compression and injury, (5) venous thromboembolism, (6/7 – tie) meningitis and encephalitis, (6/7 – tie) sepsis, (8) lung cancer, (9) traumatic brain injury and traumatic intracranial hemorrhage, (10) arterial thromboembolism, (11) spinal and intracranial abscess, (12) cardiac arrhythmia, (13) pneumonia, (14) gastrointestinal perforation and rupture, and (15) intestinal obstruction. Average disease-specific error rates ranged from 1.5 percent (myocardial infarction) to 56 percent (spinal abscess), with additional variation by clinical presentation (e.g., missed stroke average 17%, but 4% for weakness and 40% for dizziness/vertigo). There was also wide, superimposed variation by hospital (e.g., missed myocardial infarction 0% to 29% across hospitals within a single study). An estimated 5.7 percent (95% CI 4.4 to 7.1) of all ED visits had at least one diagnostic error. Estimated preventable adverse event rates were as follows: any harm severity (2.0%, 95% CI 1.0 to 3.6), any serious harms (0.3%, PR 0.1 to 0.7), and deaths (0.2%, PR 0.1 to 0.4). While most disease-specific error rates derived from mainly U.S.-based studies, overall error and harm rates were derived from three prospective studies conducted outside the United States (in Canada, Spain, and Switzerland, with combined n=1,758). If overall rates are generalizable to all U.S. ED visits (130 million, 95% CI 116 to 144), this would translate to 7.4 million (PR 5.1 to 10.2) ED diagnostic errors annually; 2.6 million (PR 1.1 to 5.2) diagnostic adverse events with preventable harms; and 371,000 (PR 142,000 to 909,000) serious misdiagnosis-related harms, including more than 100,000 permanent, high-severity disabilities and 250,000 deaths. Although errors were often multifactorial, 89 percent (95% CI 88 to 90) of diagnostic error malpractice claims involved failures of clinical decision-making or judgment, regardless of the underlying disease present. Key process failures were errors in diagnostic assessment, test ordering, and test interpretation. Most often these were attributed to inadequate knowledge, skills, or reasoning, particularly in “atypical” or otherwise subtle case presentations. Limitations included use of malpractice claims and incident reports for distribution of diseases leading to serious harms, reliance on a small number of non-U.S. studies for overall (disease-agnostic) diagnostic error and harm rates, and methodologic variability across studies in measuring disease-specific rates, determining preventability, and assessing causal factors. Conclusions. Although estimated ED error rates are low (and comparable to those found in other clinical settings), the number of patients potentially impacted is large. Not all diagnostic errors or harms are preventable, but wide variability in diagnostic error rates across diseases, symptoms, and hospitals suggests improvement is possible. With 130 million U.S. ED visits, estimated rates for diagnostic error (5.7%), misdiagnosis-related harms (2.0%), and serious misdiagnosis-related harms (0.3%) could translate to more than 7 million errors, 2.5 million harms, and 350,000 patients suffering potentially preventable permanent disability or death. Over two-thirds of serious harms are attributable to just 15 diseases and linked to cognitive errors, particularly in cases with “atypical” manifestations. Scalable solutions to enhance bedside diagnostic processes are needed, and these should target the most commonly misdiagnosed clinical presentations of key diseases causing serious harms. New studies should confirm overall rates are representative of current U.S.-based ED practice and focus on identified evidence gaps (errors among common diseases with lower-severity harms, pediatric ED errors and harms, dynamic systems factors such as overcrowding, and false positives). Policy changes to consider based on this review include: (1) standardizing measurement and research results reporting to maximize comparability of measures of diagnostic error and misdiagnosis-related harms; (2) creating a National Diagnostic Performance Dashboard to track performance; and (3) using multiple policy levers (e.g., research funding, public accountability, payment reforms) to facilitate the rapid development and deployment of solutions to address this critically important patient safety concern.