Статті в журналах з теми "551.480 11"
Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: 551.480 11.
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 статей у журналах для дослідження на тему "551.480 11".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте статті в журналах для різних дисциплін та оформлюйте правильно вашу бібліографію.
1
Jäger, Ralf, Martin Purpura, Jaci Davis, Nikolas Keratsopoulos, Mandy E. Parra, Ariane H. Secrest, Grant M. Tinsley, and Lem Taylor. "Glycoprotein Matrix Zinc Exhibits Improved Absorption: A Randomized Crossover Trial." Nutrients 16, no. 7 (March 30, 2024): 1012. http://dx.doi.org/10.3390/nu16071012.
Анотація:
Biotransformation of minerals via glycosylation by microorganisms such as yeast and/or probiotics yields nutrients bound to a food matrix, resulting in increased bioavailability. The purpose of this study was to compare the effects of glycoprotein matrix-bound zinc (GPM) on absorption compared to inorganic zinc oxide. Sixteen participants ingested 11 mg of zinc as either GPM™ Soy-Free Zinc (GPM, Ashland, Kearny, NJ, USA) or zinc oxide (USP). Blood samples were taken at 0 (i.e., baseline), 30, 60, 90, 120, 180, 240, 300, 360, 420, and 480 min post-ingestion. GPM zinc concentrations were significantly higher at 120 min (p = 0.02; 12.4 ± 5.1 mcg/dL), 180 min (p = 0.002; 16.8 ± 5.1 mcg/dL), and 240 min (p = 0.007; 14.6 ± 5.1 mcg/dL) in comparison to USP zinc oxide. In addition, GPM zinc significantly increased iAUC by 40% (5840 ± 2684 vs. 4183 ± 1132 mcg/dL * 480 min, p = 0.02), and Cmax values were 10% higher in GPM compared to USP (148 ± 21 mcg/dL vs. 135 ± 17.5 mcg/dL, p = 0.08). Tmax was 12% slower in GPM compared to USP (112.5 ± 38.7 min vs. 127.5 ± 43.1 min); however, differences in Tmax failed to reach statistical significance (p = 0.28). Zinc bound to a glycoprotein matrix significantly increased absorption compared to zinc oxide.
2
Ortiz-Moreno, Martha Lucia, Jaleydi Cárdenas-Poblador, Julián Agredo, and Laura Vanessa Solarte-Murillo. "Modeling the effects of light wavelength on the growth of Nostoc ellipsosporum." Universitas Scientiarum 25, no. 1 (May 6, 2020): 113–48. http://dx.doi.org/10.11144/javeriana.sc25-1.mte.
Анотація:
Mathematical models provide information about population dynamics under different conditions. In the study, four models were evaluated and employed to describe the growth kinetics of Nostoc ellipsosporum with different light wavelengths: Baranyi-Roberts, Modified Gompertz, Modified Logistic, and Richards. N. ellipsosporum was grown in BG-11 liquid medium for 9 days, using 12 hours of photoperiod and the following treatments: white light (400-800 nm), red light (650-800 nm), yellow light (550-580 nm) and blue light (460-480 nm). Each experiment was performed in triplicate. The optical density (OD) was measured on days 1, 3, 5, 7 and 9, using a spectrophotometer at 650 nm. The maximum cell growth was obtained under white light (OD650 : 0.090 ± 0.008), followed by the yellow light (OD650 :0.057 ± 0.004). Conversely, blue light showed a marked inhibitory effect on the growth of N. ellipsosporum (OD650 : 0.009 ± 0.001). The results revealed that the Baranyi-Roberts model had a better fit with the experimental data from N. ellipsosporum growth in all four treatments. The findings from this modeling study could be used in several biotechnological applications that require the productionof N. ellipsosporum and its bioproducts.
3
Kantarjian, Hagop M., Richard A. Larson, Francois Guilhot, Stephen G. O’Brien, and Brian J. Druker. "Declining Rates of Adverse Events (AEs), Rare Occurrence of Serious AEs (SAEs), and No Unexpected Long-Term Side Effects at 5 Years in Patients with Newly Diagnosed Chronic Myeloid Leukemia (CML) in Chronic Phase (CP) Initially Treated with Imatinib (IM) in the International Randomized Study of Interferon vs STI571 (IRIS)." Blood 108, no. 11 (November 1, 2006): 2136. http://dx.doi.org/10.1182/blood.v108.11.2136.2136.
Анотація:
Abstract The IRIS trial compared interferon alfa + cytarabine (IFN+Ara-C) and imatinib (IM) in patients (pts) with newly diagnosed CML-CP. Among 553 pts randomized to receive 400 mg IM, 157 (28%) discontinued for reasons which included AEs or deaths unrelated to CML and treatment (6%) and unsatisfactory therapeutic effect (11%). Only 2.4% discontinued due to drug-related AEs. The average daily dose was 389±71 mg, suggesting that no major dose modifications were required due to toxicity. In pts still on IM, the average doses was 382±50 mg. Average duration of exposure is 50 mos (median 60 mos). Table 1 summarizes the most frequently reported non-hematologic AEs (regardless of relationship to study drug) in pts who started IM therapy and those who were still on IM at 2 and 4 years (n=456 and 409 respectively). Table 1. AEs (≥ 20%) on First-Line Imatinib Therapy AE All grades N= 551 (%) All grades, after 2 yrs N = 456 (%) All grades, after 4 yrs N = 409 (%) Grades 3/4 N= 551 (%) Fluid retention 61.7 20.2 5.6 2.5 – Superficial edema 59.9 18.2 5.1 1.5 – Other fluid retention events 6.9 2.4 0.7 1.3 Nausea 49.5 15.4 3.4 1.3 Muscle cramps 49.2 22.8 7.3 2.2 Musculoskeletal pain 47.0 20.8 6.1 5.4 Diarrhea 45.4 23.0 5.1 3.3 Rash and related terms 40.1 13.8 2.4 2.9 Fatigue 38.8 11.4 2.9 1.8 Headache 37.0 12.1 3.4 0.5 Abdominal pain 36.5 15.4 3.4 4.2 Joint pain 31.4 9.2 2.0 2.5 Nasopharyngitis 30.5 14.3 3.7 0 Hemorrhage 28.9 14.3 5.1 1.8 Myalgia 24.1 4.6 1.5 1.5 Vomiting 22.5 9.2 3.7 2.0 Upper respiratory tract infection 21.2 11.2 2.7 0.2 Cough 20.0 7.7 3.4 0.2 Hematologic toxicities were the most frequently occurring grade 3/4 AEs (Table 2). Table 2. Grade 3/4 laboratory abnormalities on First-line Imatinib Overall N = 551 (%) After 2 years N= 456 (%) After 4 years N= 409 (%) Hematologic – Neutropenia 16.7 7 1.0 – Thrombocytopenia 8.9 1.5 0.2 – Anemia 4.4 1.8 0.5 Biochemical – ↑ SGOT/SGPT 5.3 0.4 0 – ↑Total bilirubin 1.1 0.4 0.2 The most frequent reported AEs as well as grade 3/4 hematological and biochemical toxicities were observed at decreasing frequencies throughout therapy. After 4 years, 8% of pts experienced an SAE, compared with 14%, 12%, 7.5%, and 9% during year one through four of therapy. Overall, only 6% of pts had SAEs considered related to study drug (1.5% pts after 4 years of IM). Congestive heart failure/cardiac dysfunction (incl. pulmonary edemas) were reported for 3% of pts (<1% grade 3/4) and pleural effusion in 1% (<1% grade 3/4). Despite much shorter average exposure (12 mos), similar % of these AEs were noted for IFN+Ara-C. Although it should be considered that pts more likely to experience grade 3/4 events may have discontinued from the study prematurely, the 5-year data with IM in pts with newly diagnosed CML-CP show declining frequencies of AEs and SAEs over time. Occurrence of SAEs and laboratory abnormalities with long-term follow-up was rare. No unexpected long-term side effects were noted. These results confirm the IM tolerability and safety profile for durations exceeding 4 years.
4
Saputra, Ihsan, Nugroho Pratomo Ariyanto, and Mikie Febri. "Pengaruh Temperatur Tempering Terhadap Pembentukan Struktur Mikro Dan Kekerasan Baja Skd 11 Untuk Tool Steel." Jurnal Teknologi dan Riset Terapan (JATRA) 2, no. 1 (June 30, 2020): 10–13. http://dx.doi.org/10.30871/jatra.v2i1.1787.
Анотація:
SKD 11 steel is a tool steel which is often applied in the manufacturing industry, such as cutting, punching, stamping tools, shear blades, dies and others. And in it’s application, of course steel must have a hard structure, strong and touhgness affected due to external forces causing deformation or change in shape. To improve the quality, heat treatment is required on the steel by providing austenizing, quenching and tempering temperature variations 400 °C, 550 °C and 650 °C. Which purpose to determine the hardness and microstructure of the tempering variation results. The first step of cutting material SKD 11 steel, followed by austenizing process up to 1050 °C and then quenching process (fast cooling) with medium water and continue the process of tempering variation 400 °C, 550 °C and 650 °C. After the heat treatment was complete, take hardness test and view the microstructure of the SKD 11 steel. At temperatures tempering 400 °C showed the highest hardness value of 56.5 HRC, followed by tempering temperatures 550 °C at 52.9 HRC and the lowest occurred at temperature tempering 650 °C at 39.1 HRC. Microstructure formed pearlite and martensite. Then the higher temperature tempering then the declining value of steel hardness SKD 11.
5
Peng, Kuan, Dang Quan Zhang, and Huai Yun Zhang. "550°C-Based Py-GC/MS Analysis of Chemical Components of Benzene/Ethanol Extractives from Trunk Bark of Cinnamomum camphora." Key Engineering Materials 480-481 (June 2011): 496–501. http://dx.doi.org/10.4028/www.scientific.net/kem.480-481.496.
Анотація:
Researches about the analysis and identificaion of chemical components of old bark from Cinnamomum camphora trunk were very less. Therefore, 550 °C-based pyrolysis- GC/MS technology was used to identify the top value-added biomedical constituents of old bark-based benzene/ethanol extractives from C. camphora trunk. 107 chemical constituents representing 99.316% were identified from 120 peaks. The main components are as: 1-Nonadecene (6.313% from two peaks), Octacosane (5.749% from two peaks), Octacosanoic acid, methyl ester (4.706%), 9-Tricosene, (Z)- (4.273% from seven peaks), 2-Methoxy-4-vinylphenol (2.385% from three peaks), Pyridine-3-carboxamide, oxime, N-(2-trifluoromethylphenyl)- (2.320% from three peaks), 25-Noroleana-9,12-dien-29-oic acid, 5-methyl-11-oxo-, (18.alpha.)- (2.165%), Cyclotriacontane (2.117%), Nonacosane (1.947%), 2-Pentene, (E)- (1.933%), Octadecane (1.932% from two peaks), Octacosane (1.898%), Hexacosanoic acid, methyl ester (1.861%), 1,2-Benzenedicarboxylic acid, butyl 2-methylpropyl ester (1.849%), Tetracosanoic acid, methyl ester (1.774%), 1-Hexene (1.742), Cyclotetracosane (1.719%), Hexadecane (1.435% from two peaks), etc. The result of functional analysis suggested that the 550 °C pyrolyzate of benzene/ethanol extractives from C. camphora old bark is abundant in biomedical constituents and other bioactive components, which can be used as top value-added materials of high-grade cosmetic, food, spice and chemical solvents.
6
Kozlov, V. K., M. Sh Garifullin, A. Kh Sabitov, and R. A. Giniatullin. "FLUORESCENT PROPERTIES OF PAPER INSULATION OF OIL-FILLED TRANSFORMERS." Proceedings of the higher educational institutions. ENERGY SECTOR PROBLEMS 20, no. 11-12 (February 27, 2019): 144–51. http://dx.doi.org/10.30724/1998-9903-2018-20-11-12-144-151.
Анотація:
The effect of paper thermal destruction on its luminescence spectra and luminescence excitation spectra in the spectral ranges of 400-550 nm and 250-450 nm, respectively, was studied. It is proposed to use the characteristic changes in the intensity and shape of the luminescence spectra as a criterion for the state of paper insulation of power transformers. On the basis of the analysis performed, it was concluded that when luminescence is excited at a wavelength of 360 nm, none of the main components of the paper can contribute to the recorded luminescence spectra. It is assumed that the resulting luminescence spectra are due to the emission of various impurities that enter the paper during its production.
7
Gabey, A. M., W. R. Stanley, M. W. Gallagher та P. H. Kaye. "The fluorescence properties of aerosol larger than 0.8 μm in an urban and a PBA-dominated location". Atmospheric Chemistry and Physics Discussions 11, № 1 (7 січня 2011): 531–66. http://dx.doi.org/10.5194/acpd-11-531-2011.
Анотація:
Abstract. Dual-wavelength Ultraviolet light-induced fluorescence (UV-LIF) measurements were performed on ambient environmental aerosol in Manchester, UK (urban city centre, winter) and Borneo, Malaysia (remote, tropical), which are taken to represent environments with negligible and significant primary biological aerosol (PBA) influences, respectively. Single-particle fluorescence intensity and optical equivalent diameter were measured with a Wide Issue Bioaerosol Sensor, version 3 (WIBS3) in the diameter range 0.8 μm≤DP≤20 μm for 2–3 weeks and filters were analysed using energy dispersive X-ray (EDX) spectroscopy, which revealed mostly non-PBA dominated particle sizes larger than 1 μm in Manchester. The WIBS3 features three fluorescence channels: Fluorescence excited at 280 nm is recorded at 310–400 nm and 400–600 nm and fluorescence excited at 370 nm is detected at 400–600 nm. In Manchester the primary size mode of fluorescent and non-fluorescent material was at 1.2 μm. In Borneo non-fluorescent material peaked at 1.2 μm and fluorescent at 3–4 μm. The fluorescence intensity at 400–600 nm generally increased with DP at both sites, as did the 310–400 nm intensity in Borneo. In Manchester the 310–400 m fluorescence decreased at DP>4 μm, suggesting this channel offers additional discrimination between fluorescent particle types. Finally, the ratio of fluorescence intensity in two pairs of channels was investigated as a function of particle diameter and this varied significantly between the two environments, demonstrating that the fluorescent aerosol in each can in principle be distinguished using a combination of fluorescence and elastic scattering measurements.
8
Prokopenko, A. A., E. V. Bezrukova, G. K. Khursevich, E. P. Solotchina, M. I. Kuzmin, and P. E. Tarasov. "Climate in continental interior Asia during the longest interglacial of the past 500 000 years: the new MIS 11 records from Lake Baikal, SE Siberia." Climate of the Past 6, no. 1 (January 20, 2010): 31–48. http://dx.doi.org/10.5194/cp-6-31-2010.
Анотація:
Abstract. A synthesis of paleoclimate responses from Lake Baikal during the MIS 11 interglacial is presented based on proxy records from two drill sites 245 km apart. BDP-99 is located in vicinity of the delta of the major Baikal tributary, whereas the BDP-96 site represents hemipelagic setting distant from riverine influence. The comparison of thicknesses of interglacial intervals in these contrasting depositional settings confirms the extended ca. 33-kyr duration of the MIS 11 interglacial. The new BDP-99 diatom biostratigraphic record matches that of the BDP-96-2 holostratotype and thus allows establishing establishes robust correlation between the records on the same orbitally-tuned timescale. The first detailed MIS 11 palynological record from the BDP-99 drill core indicates the dominance of boreal conifer (taiga) forest vegetation in the Baikal region throughout the MIS 11 interglacial, since at least 424 ka till ca. 396 ka. The interval ca. 420–405 ka stands out as a "conifer optimum" with abundant Abies sibirica, indicative of climate significantly warmer and less continental than today. The closest Baikal analog to this type of vegetation in the history of the current Holocene interglacial is at ca. 9–7 ka. The warm conifer phase lasted for ca. 15 kyr during MIS 11 interrupted by two millennial-scale cooling episodes at ca. 411–410 and 405–404 ka. Reconstructed annual precipitation of 450–550 mm/yr during the MIS 11 interglacial is by ca. 100 mm higher than during the Holocene; regional climate was less continental with warmer mean temperatures both in summer and in winter. At both drill sites, the two-peak structure of the MIS 11 diatom abundance profiles reflects the orbital signature of precession in the interglacial paleoclimate record of continental Eurasia. MIS 11 interglacial was characterized by the sustained high level of primary production and accumulation of autochthonous organic matter at both study sites. The responses of paleoclimate-sensitive indices in the mineralogy of the MIS 11 sediments in BDP-96-2 are consistent with those during the Holocene. Illitization of secondary clay minerals in the Baikal watershed was an important process, but it appears to have been subdued during the first half of the MIS 11, apparently due to elevated humidity and muted seasonality of regional climate.
9
Wang, H., X. Liu, K. Chance, G. Gonzalez Abad, and C. Chan Miller. "Water vapor retrieval from OMI visible spectra." Atmospheric Measurement Techniques Discussions 7, no. 1 (January 22, 2014): 541–67. http://dx.doi.org/10.5194/amtd-7-541-2014.
Анотація:
Abstract. There are distinct spectral features of water vapor in the wavelength range covered by the Ozone Monitoring Instrument (OMI) visible channel. Although these features are much weaker than those at longer wavelengths, they can be exploited to retrieve useful information about water vapor. They have an advantage in that their small optical depth leads to fairly simple interpretation as measurements of the total water vapor column density. We have used the Smithsonian Astrophysical Observatory (SAO)'s OMI operational retrieval algorithm to derive the Slant Column Density (SCD) of water vapor from OMI measurements using the 430–480 nm spectral region after extensive optimization of retrieval windows and parameters. The Air Mass Factor (AMF) is calculated using look-up tables of scattering weights and monthly mean water vapor profiles from the GEOS-5 assimilation products. We convert from SCD to Vertical Column Density (VCD) using the AMF and generate associated retrieval averaging kernels and shape factors. Our standard water vapor product has a median SCD of ~ 1.3 × 1023 molecule cm−2 and a median relative uncertainty of ~ 11% in the tropics, about a factor of 2 better than that from a similar OMI algorithm but using narrower retrieval window. The corresponding median VCD is ~ 1.2 × 1023 molecule cm−2. We have also explored the sensitivities to various parameters and compared our results with those from the Moderate-resolution Imaging Spectroradiometer (MODIS) and the Aerosol Robotic NETwork (AERONET).
10
Ben salem, N., A. Belghith, Z. Ben zina, M. Dhouib, A. Mallek, A. Mnif, F. Karray, H. Ben Amor, and M. Abdelmoula. "440 Les fractures du plancher de l’orbite de type « blow-out » pur : à propos de 11 cas." Journal Français d'Ophtalmologie 30 (April 2007): 2S278. http://dx.doi.org/10.1016/s0181-5512(07)80253-1.
11
Mahalingam, Savisha, Huda Abdullah, Azimah Omar, Nurul Ain Md Nawi, Sahbudin Shaari, Andanastuti Muchtar, and Izamarlina Asshari. "Effect of Morphology on SnO2/MWCNT-Based DSSC Performance with Various Annealing Temperatures." Advanced Materials Research 1107 (June 2015): 649–54. http://dx.doi.org/10.4028/www.scientific.net/amr.1107.649.
Анотація:
Development of tin/multi-walled carbon nanotube (SnO2/MWCNTs) thin films were prepared by sol-gel method. The synthesis of tin oxide (SnO2) was carried out by dissolving tin (II) chloride (SnCl3) in a solvent of 2-methoxyethanol. Different annealing temperatures of 400 °C, 450 °C, 500 °C, 550 °C and 600 °C were proposed in this study. The changes in the structural properties were analyzed by means of transmission electron microscopy (TEM) and atomic force microscopy (AFM) analysis. AFM results indicated very rough surface area of SnO2/MWCNTs thin films where roughness values increased linearly from 1.8 nm to 11 nm by increasing the annealing temperatures from 400 °C to 600 °C. The SnO2/MWCNTs-based DSSC exhibited good photovoltaic performance with power conversion efficiency (η), photocurrent density (Jsc), open circuit voltage (Voc) and fill factor (FF) of 0.62 %, 5.6 mA cm-2, 0.55 V and 0.65 respectively. The obtained structural and photovoltaic performance analysis was proposed as a suitable benchmark for Sn/MWCNTs based dye-sensitized solar cell (DSSC) application.
12
Lindawati, Lindawati, Marietta Shanti, and Tri Damiati. "Nilai Rerata Jarak Tempuh Uji Jalan 6 Menit Pada Anak Sehat Usia 10-14 Tahun Di Bandung dan Hubungannya dengan Panjang Tungkai." Unram Medical Journal 5, no. 3 (September 28, 2016): 1. http://dx.doi.org/10.29303/jku.v5i3.294.
Анотація:
Pendahuluan: Uji jalan 6 menit (6MWT) merupakan uji latih submaksimal, dengan variabel utama yang diukur adalah jarak tempuh dalam 6 menit. Jarak tempuh 6 MWT akan dipengaruhi oleh kecepatan jalan yang akan meningkat seiring dengan pertumbuhan anak, terutama disebabkan karena peningkatan panjang langkah. Pertambahan panjang tungkai akan memengaruhi pertambahan panjang langkah.
Metode: deskriptif analitik dengan desain cross-sectional.
Hasil: Jarak tempuh 6MWT di lintasan 15 meter pada anak laki-laki usia 10, 11, 12, 13 dan 14 tahun adalah 485,5 (395-585) m, 521 (432-660) m, 524 (431-694,2) m, 560 (449-675) m, dan 540 (439-664,5) m. Jarak tempuh 6MWT pada lintasan 15 meter untuk anak perempuan usia 10, 11, 12, 13, dan 14 tahun adalah 497 (353-742) m, 553 (420-662) m, 559 (428,1-658) m, 551,3 (373-685) m, dan 545,6 (464-600) m. Panjang tungkai berkorelasi bermakna dengan jarak tempuh 6MWT (p<0,001). Berdasarkan uji regresi didapatkan rumus prediksi jarak tempuh 6MWT untuk anak sehat usia 10-14 tahun pada lintasan 15 m yaitu 6,872 x panjang tungkai (cm).
Kesimpulan: Panjang tungkai memiliki korelasi dengan jarak tempuh 6MWT, dan dapat digunakan untuk memprediksi jarak tempuh 6MWT pada anak sehat usia 10-14 tahun di lintasan 15 m.
13
VISMAN, INGRID M., GEERTJE M. BARTELDS, WOUTER OUWERKERK, ANITA C. J. RAVELLI, LINDA M. PEELEN, BEN A. C. DIJKMANS, MAARTEN BOERS, and MIKE T. NURMOHAMED. "Effect of the Application of Trial Inclusion Criteria on the Efficacy of Adalimumab Therapy in a Rheumatoid Arthritis Cohort." Journal of Rheumatology 38, no. 9 (June 15, 2011): 1884–90. http://dx.doi.org/10.3899/jrheum.101283.
Анотація:
Objective.To evaluate the influence of inclusion criteria used in rheumatoid arthritis (RA) trials with adalimumab on clinical outcome and response.Methods.The different inclusion criteria of published trials of adalimumab in RA were separately applied to a large prospective cohort of patients with RA treated with adalimumab (AdRA cohort), thereby mimicking patient selection for a clinical trial. Clinical response and outcome in the resulting 11 projection groups were compared using the 28-joint Disease Activity Score (DAS28) and time-averaged DAS28 as outcome measures of efficacy.Results.Thirteen trials (n = 54–799) with 11 different sets of entry criteria were identified, resulting in 11 projection groups (n = 22–168). The DAS28 at baseline was similar in the original trial and each projection group based on this trial (5.1–6.4, total AdRA cohort 5.1). After 28 weeks, the efficacy varied substantially among the 11 projected groups (change from baseline DAS28: −1.65 to −2.65, time-averaged DAS28 3.67–4.53). Expressed as outcome (DAS28 at 28 weeks), the efficacy was much more similar for almost all projection groups (3.5–4.0) and thus appeared to be mostly independent of disease activity at baseline.Conclusion.We observed that different inclusion criteria for clinical trials can have a marked effect on the expected response, i.e., improvement from baseline. A novel finding is that final disease activity appeared much less dependent on initial disease activity. Our study suggests that for daily practice, one can assume that adalimumab treatment will on average result in a DAS28 between 3.5 and 4.0 after 28 weeks of treatment, regardless of baseline disease activity.
14
McGrath, R. T., and A. G. Kellman. "Technology and plasma-materials interaction processes of tokamak disruptions." Nuclear Fusion 32, no. 11 (November 1992): 2054–55. http://dx.doi.org/10.1088/0029-5515/32/11/420.
15
Islam, Dr Mohammad Zahirul, Dr AKM Moinuddin, Dr Md Abul Hashem, Dr Sabuj Baran Dhar, Dr Mohammad Alauddin, and Dr Rahat Sultan Bhuiyan. "Incidence and Related Factors of Different Types of Skin Diseases among Children." Scholars Journal of Applied Medical Sciences 10, no. 12 (December 10, 2022): 2348–53. http://dx.doi.org/10.36347/sjams.2022.v10i12.045.
Анотація:
Background: The global burden of non-fatal diseases is greatly increased by skin problems. Children bear a disproportionately large portion of the burden of skin problems, which are also responsible for numerous visits to primary healthcare institutions. Objective: The goal of this study was to estimate the incidence of skin conditions in children and describe how they relate to different factors. Methods: This study was a prospective cross-sectional study conducted among 1722 patients at outpatient department (OPD) of Paediatrics in Abdul Malek Ukil Medical College Hospital, Noakhali, Bangladesh; from 1 April to 31 July 2022. Where 1040 Participants less than or equal to 15 years old and of both sexes who visited the hospital's Paediatrics department for Skin & Venereal diseases were included in this study. Result: A total of 1040 participants were recruited in this study, out of which 550 (52.9%) were boys and 490 (47.1%) were girls. 170 (16.3%) were aged between 0-5 years and followed by 410 (39.4%) were 6-10 years, 460 (44.2%) were 11-15 years. 620 (59.6%) were rural and 420 (40.4%) were urban. The majority of mothers, 484 (46.5%), were educated up to primary level. Most of the fathers, 502 (48.3%), studied up to secondary level. The majority of the participants, 263 (46.1%), had fungal infectious diseases whereas 178 (37.9%) of children had eczema, a non-infectious disease. Conclusion: The study comes to the conclusion that most prevalent type of skin illness identified in this study was fungal infection, followed by eczema and urticaria. Age, education level of parents, poor personal hygiene, history of prior skin disease, sharing of clothing and towels with other family members and socioeconomic position were the related factors that linked to skin disease in children.
16
Dursun, E., S. Le Goff, DN Ruse, and JP Attal. "Effect of Chlorhexidine Application on the Long-term Shear Bond Strength to Dentin of a Resin-modified Glass Ionomer." Operative Dentistry 38, no. 3 (April 1, 2013): 275–81. http://dx.doi.org/10.2341/11-501-l.
Анотація:
SUMMARY Purpose The aim of this study was to investigate the effect of chlorhexidine digluconate (CHX) application on the shear bond strength (SBS) of a resin-modified glass ionomer cement (RMGIC) to polyalkenoic acid–preconditioned dentin after 24 hours, six months, and 12 months of water storage at 37°C. Materials and Methods Cylindrical molds, placed on flat, polyalkenoic acid (Cavity Conditioner® [GC]) preconditioned dentin surfaces of 90 human teeth embedded in resin, were filled with Fuji II LC® (GC), a RMGIC, with (n=45) or without (n=45) the prior application of a 0.05% CHX solution. Within each group, SBS was determined after 24 hours (n=15), six months (n=15), and 12 months (n=15) of storage in water at 37°C. The results were analyzed with two-way analysis of variance followed by Tukey multiple means comparisons (p<0.05). The type of bond failure (adhesive/cohesive/mixed) was noted and the results were analyzed with chi-square test (p<0.05). Results After 24 hours, the SBS of RMGIC was not significantly different with (9.0 ± 2.8 MPa) or without (8.3±0.6 MPa) the application of CHX. After six months, however, SBS increased significantly in the group without CHX (12.7±3.4 MPa) but remained unchanged in the CHX group (9.4±4.0 MPa). Similar results without CHX (12.6±3.8 MPa) and with CHX (9.5±3.2 MPa) were obtained after 12 months. No significant differences in the type of debonding were found between the various groups tested. Conclusion The application of 0.05% CHX after dentin preconditioning did not seem to have affected the 24-hour SBS of RMGIC. However, the six- and 12-month SBS was significantly lower for CHX-treated samples, possibly as a result of CHX interference with both the bonding mechanism and the maturation reaction of RMGIC.
17
Singh, Balwant, Bhupinder Pal Singh, and Annette L. Cowie. "Characterisation and evaluation of biochars for their application as a soil amendment." Soil Research 48, no. 7 (2010): 516. http://dx.doi.org/10.1071/sr10058.
Анотація:
Biochar properties can be significantly influenced by feedstock source and pyrolysis conditions; this warrants detailed characterisation of biochars for their application to improve soil fertility and sequester carbon. We characterised 11 biochars, made from 5 feedstocks [Eucalyptus saligna wood (at 400°C and 550°C both with and without steam activation); E. saligna leaves (at 400°C and 550°C with activation); papermill sludge (at 550°C with activation); poultry litter and cow manure (each at 400°C without activation and at 550°C with activation)] using standard or modified soil chemical procedures. Biochar pH values varied from near neutral to highly alkaline. In general, wood biochars had higher total C, lower ash content, lower total N, P, K, S, Ca, Mg, Al, Na, and Cu contents, and lower potential cation exchange capacity (CEC) and exchangeable cations than the manure-based biochars, and the leaf biochars were generally in-between. Papermill sludge biochar had the highest total and exchangeable Ca, CaCO3 equivalence, total Cu, and potential CEC, and the lowest total and exchangeable K. Water-soluble salts were higher in the manure-based biochars, followed by leaf, papermill sludge, and wood biochars. Total As, Cd, Pb, and polycyclic aromatic hydrocarbons in the biochars were either very low or below detection limits. In general, increase in pyrolysis temperature increased the ash content, pH, and surface basicity and decreased surface acidity. The activation treatment had a little effect on most of the biochar properties. X-ray diffraction analysis showed the presence of whewellite in E. saligna biochars produced at 400°C, and the whewellite was converted to calcite in biochars formed at 550°C. Papermill sludge biochar contained the largest amount of calcite. Water-soluble salts and calcite interfered with surface charge measurements and should be removed before the surface charge measurements of biochar. The biochars used in the study ranged from C-rich to nutrient-rich to lime-rich soil amendment, and these properties could be optimised through feedstock formulation and pyrolysis temperature for tailored soil application.
18
Macarulla, Teresa, Maialen Barrero, Jorge Adeva, Oscar Alfredo Castillo Trujillo, Andrés J. Muñoz Martín, Paloma Peinado Martin, Helena Verdaguer, et al. "Epidemiological biliary tract cancer characterization: A patient cohort from the Spanish RETUD registry." Journal of Clinical Oncology 40, no. 4_suppl (February 1, 2022): 480. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.480.
Анотація:
480 Background: Biliary tract cancer (BTC) is a heterogeneous group of tumours, including cholangiocarcinoma (intrahepatic and extrahepatic) and gallbladder carcinoma (GC). With this work, we aim to perform an epidemiological characterization of patients with BTC, their management and survival outcomes from a nationwide registry in Spain. Methods: We performed an epidemiologic analysis of a cohort of patients from the Spanish RETUD registry diagnosed with BTC between 1 January 2017 and 31 December 2020. Data collected included sociodemographic and clinical outcomes, molecular analysis, oncological treatments, and survival. Patients with all the aforementioned data available on the cut-off date of 7 July 2021 were considered in the analysis. It included descriptive statistics of patient characteristics, tumour molecular markers and treatments. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Results: A total of 778 evaluable patients were included in 19 sites, with a median (interquartile range, IQR) age of 72.2 (64.5-78.5) years, 54.8% men. At primary diagnosis, the tumour was mostly intrahepatic (57.2%); followed by extrahepatic (27.4%) and GC (13.8%) and histologically diagnosed (83.7%). Most of the patients has advanced disease at diagnosis (72.0%). At database cut-off, the disease was metastatic in 525 (67.5%) patients, and the main metastatic sites were the liver n = 333 (63.4%), lymph distant nodes n = 187 (35.6%) and peritoneum n = 175 (33.3%). Any biomarker analysis was done in 245 (31.5%) patients whose main findings were: IDH1 mutations (n = 33, 17.7%), FGFR2 fusions (n = 15, 8.4%), BRAFV600E mutation (n = 10, 5.7%), MSI (n = 14, 6.8%) and HER2 amplification (n = 5, 3.0%). Previous surgeries were reported in 261 (33.5%) patients, and systemic oncologic therapies in 586 (75.3%): neoadjuvant n = 11 (1.9%), adjuvant n = 135 (23.0%), first line n = 549 (93.7%), second line n = 237 (40.4%), and third line and beyond n = 113 (19.3%). The main first-line treatment was cisplatin/gemcitabine (CISGEM; n = 331, 64.4%), followed by gemcitabine monotherapy (n = 100, 19.5%) and gemcitabine plus oxaliplatin (GEMOX; n = 48, 9.3%). The median (95% CI) PFS from first line in patients exposed to CISGEM was 5.1 (4.6-5.8) months. The median OS in metastatic population (95% CI) was 8.3 (7.2-9.1) months. Conclusions: This analysis provides insights into the characterization of BTC, its therapeutic management and clinical outcomes in Spanish sample patients. Obtained data are consistent with the published literature; nevertheless, we must consider them in the context of a currently evolving scenario. Although molecular analysis has gained relevance, it is still poorly performed in daily practice in Spain.
19
Rumiantsev, Pavel O., Marina S. Sheremeta, Alexey V. Kiyaev, Luydmila A. Kurmyshova, and Olga A. Chikulaeva. "Efficacy and safety of radioiodine treatment of Graves’ disease in children and adolescents." Clinical and experimental thyroidology 13, no. 1 (July 7, 2017): 6–11. http://dx.doi.org/10.14341/ket201716-11.
Анотація:
There are three methods in treatment of Graves’ disease in children and adolescents – antithyroid drugs, surgery and radioiodine therapy (RIT). However, treatment protocol of children and adolescents doesn’t exist. In the present case series study we have evaluated the effectiveness and safety of RIT in children and adolescents. We have observed totally 25 patients in age 11–17 years old (mean 14.8 years) with Graves’ disease. Ten patients were treated with RIT in Endocrinology Research Centre (Moscow) in 2016 year with activities 550–920 MBq. Follow-up period varied 6–11 months in this subgroup. The second subgroup (15 patients) was treated in radiology department in Nijniy Tagil rural hospital (Ural region) in the period 2005–2012 years. Follow-up period varied 3.5–11.5 years (mean 8.5 years). RIT was executed in all patients without any complications, direct or long-term. In two patients having endocrine ophtalmopathy in non-active phase it was no any signs of worsening in result of RIT. In 17 (68%) of 25 patients the hypothyroidism occurred through 6 months. In one case – euthyroidism. In remain 7 observations the hyperthyroidism recurred. Patient subgroups didn’t differ in mean age, gender ratio, thyroid size and autoantibodies to TSH receptor levels, but were differed in treatment 131I activities (subset from ERC – 550–920 MBq; subset from Nijniy Tagil – 168–400 MBq). However the treatment efficacy did not differ significantly (p = 0.99): 68% and 73%, accordingly. In conclusion, RIT of Graves’ disease in a safe and effective method of treatment for hyperthyroidism in children and adolescents. It’s necessary to prolong study in numerous patients cohort, longer-lasting follow-up period as well as to improve RIT efficiency.
20
Qinglin, Guo, Hiromi Takabayashi, Toshio Nakamura, Chen Gangquan, Ken Okada, Su Bomin, Fan Yuquan, and Hiroshi Nishimoto. "Radiocarbon Chronology for Early Caves of the Mogao Grottoes at Dunhuang, China." Radiocarbon 52, no. 2 (2010): 500–510. http://dx.doi.org/10.1017/s0033822200045537.
Анотація:
The Mogao Grottoes site at Dunhuang is one of the largest stone cave temples in China. The site features 735 caves with Buddhist mural paintings. To investigate the chronology of early caves of the Mogao Grottoes, radiocarbon dates were measured by accelerator mass spectrometry (AMS) on plant remains collected from 4 caves: 268, 272, 275, and 285. Caves 268, 272, and 275 are regarded (by archaeological analysis) to be the earliest existing caves in the Mogao Grottoes. The fourth cave, 285, features inscriptions on the north wall mentioning the oldest dates of the Chinese Mogao era. Plant materials, taken from the plaster layer of mural paintings and core materials from statues, were collected as samples (n = 11) for AMS 14C dating at Nagoya University. Two samples from cave 275 gave calibrated 14C ages of cal AD 380–430 (1 σ). The other samples resulted in a time interval of cal AD 400–550. The calibrated 14C ages obtained for the samples taken from painted murals and the statues in cave 285 are consistent with the date given by the inscription remaining on the cave's north wall.
21
Hirooka, S., K. Hattori, M. Nishihashi, and T. Takeda. "Neural network based tomographic approach to detect earthquake-related ionospheric anomalies." Natural Hazards and Earth System Sciences 11, no. 8 (August 26, 2011): 2341–53. http://dx.doi.org/10.5194/nhess-11-2341-2011.
Анотація:
Abstract. A tomographic approach is used to investigate the fine structure of electron density in the ionosphere. In the present paper, the Residual Minimization Training Neural Network (RMTNN) method is selected as the ionospheric tomography with which to investigate the detailed structure that may be associated with earthquakes. The 2007 Southern Sumatra earthquake (M = 8.5) was selected because significant decreases in the Total Electron Content (TEC) have been confirmed by GPS and global ionosphere map (GIM) analyses. The results of the RMTNN approach are consistent with those of TEC approaches. With respect to the analyzed earthquake, we observed significant decreases at heights of 250–400 km, especially at 330 km. However, the height that yields the maximum electron density does not change. In the obtained structures, the regions of decrease are located on the southwest and southeast sides of the Integrated Electron Content (IEC) (altitudes in the range of 400–550 km) and on the southern side of the IEC (altitudes in the range of 250–400 km). The global tendency is that the decreased region expands to the east with increasing altitude and concentrates in the Southern hemisphere over the epicenter. These results indicate that the RMTNN method is applicable to the estimation of ionospheric electron density.
22
Ren, Nai Lin, and Chi Yang. "Determination of Enoxacin in Tablet by Flow Injection Chemiluminescence." Advanced Materials Research 554-556 (July 2012): 1880–83. http://dx.doi.org/10.4028/www.scientific.net/amr.554-556.1880.
Анотація:
A new flow injection chemiluminescence (CL) method for the determination of Enoxacin（ENX）was described. The method was based on the weak CL reaction of Ce(Ⅳ)-SO32- sensitized by Pr3+- ENX. The relative CL intensity was linear with the concentration of ENX in the range of 3×10-8 g•mL-1~5.0×10-7 g•mL-1. The detection limit is 1.0×10-8 g•mL-1 .The rSuperscript textelative standard deviation (RSD) for the determination of 4.0×10-7 g•mL-1 ENX is 3.5% (n=11). The method has been successfully applied to the analysis of ENX in tablet
23
Hansen, Marianne, Brittmarie Sandström, Mikael Jensen, and Sven S. Sørensen. "Casein Phosphopeptides Improve Zinc and Calcium Absorption from Rice‐Based but not from Whole‐Grain Infant Cereal." Journal of Pediatric Gastroenterology and Nutrition 24, no. 1 (January 1997): 56–62. http://dx.doi.org/10.1002/j.1536-4801.1997.tb01452.x.
Анотація:
Background:Casein phosphopeptides (CPP) are phosphorus‐rich peptide fragments of casein, assumed to contribute to the high bioavailability of calcium from milk.Methods:The effect of casein phosphopeptides on calcium and zinc absorption from infant foods was investigated. Twenty‐two men and women were given single test meals extrinsically labeled with Ca and Zn. Absorption was calculated from measurements on whole‐body retention of the radioisotopes. Each subject was given either rice‐based cereal (n = 11) or whole‐grain cereal (n = 11) on three occasions together with 250 ml water and added 0, 1, and 2 g CPP in random order. One serving of rice‐based cereal contained 481 mg Ca and 1.29 mg Zn: whole‐grain cereal contained 541 mg Ca and 1.77 mg Zn. One and 2 g of CPP contributed with additional 69 and 138 mg Ca, respectively.Results:From rice‐based cereal, fractional calcium absorption was not affected by CPP addition (mean ± SD): 16.0 ± 4.0% (no CPP), 17.6 ± 4.5% (1 g CPP), and 15.8 ± 4.3% (2 g CPP), while the total quantity of calcium absorbed was significantly improved: 7 ± 19 mg, 97 ± 25 mg, and 98 ± 26 mg, respectively (p = 0.0004). Fractional zinc absorption as well as total quantity of zinc absorbed were increased with addition of CPP: 19.4 ± 9.0% (0.25 ± 0.12 mg), 25.2 ± 7.5% (0.33 ± 0.10 mg) and 23.9 ± 5.4% (0.31 ± 0.07 mg) at the three CPP levels (p = 0.04). From whole‐grain cereal, CPP had no effect on the percentage or actual quantity of calcium absorbed: 17.0 ± 3.2% (92 ± 18 mg), 17.2 ± 4.5% (105 ± 27 mg), and 15.0 ± 4.6% (102 ± 31 mg), respectively. Zinc absorption was also not influenced by CPP: 16.0 ± 5.1% (0.28 ± 0.09 mg), 15.3 ± 3.1% (0.27 ± 0.06 mg) and 18.1 ± 4.4% (0.32 ± 0.08 mg), respectively.Conclusions:CPP addition improved calcium and zinc absorption from rice‐based cereal, while no effect was seen from whole‐grain cereal.
24
Bianchi, Roberto, Francesco Alessandro Mistretta, Gennaro Musi, Stefano Luzzago, Michele Morelli, Vito Lorusso, Michele Catellani, et al. "Robot-Assisted Intracorporeal Orthotopic Ileal Neobladder: Description of the “Shell” Technique." Journal of Clinical Medicine 10, no. 16 (August 16, 2021): 3601. http://dx.doi.org/10.3390/jcm10163601.
Анотація:
Background: Robot-assisted radical cystectomy (RARC) with intracorporeal neobladder (ICNB) remains a very complicated, technically demanding and time-consuming surgical procedure. In the current study we describe our robot-assisted intracorporeal “Shell” neobladder reconstruction. Methods: From January 2017 to December 2019, we performed 30 intracorporeal ileal neobladder “Shell” reconstructions. We prospectively collected demographics and clinical and pathological data and retrospectively analysed perioperative, functional and oncological outcomes. Results: No conversion to open surgery or intraoperative blood transfusion was necessary. The median whole operative time was 493 min (IQR 433–530 min), ranging from 514 min (IQR 502–554 min) recorded during the first ten procedures to 470 min (IQR 442–503 min) of the last ten. The median estimated blood loss was 400 mL (IQR 350–700 mL). The median length of stay was 11 days (IQR 10–17). Both early and late complication rates were 46.7%. The high-grade early complication rate accounted for 20%, while the high-grade late complication rate was 30%. The daytime continence rate registered was 73.3%, while night-time continence rate was 60%. Conclusions: Our results demonstrated “Shell” neobladder reconstruction as a technically feasible procedure, with good functional outcomes in tertiary referral centre. Longer follow-up and larger populations are needed to validate these preliminary results.
25
Čepić, Zoran, Višnja Mihajlović, Slavko Đurić, Milan Milotić, Milena Stošić, Borivoj Stepanov, and Milana Ilić Mićunović. "Experimental Analysis of Temperature Influence on Waste Tire Pyrolysis." Energies 14, no. 17 (August 30, 2021): 5403. http://dx.doi.org/10.3390/en14175403.
Анотація:
Pyrolysis is an optimal thermochemical process for obtaining valuable products (char, oil, and gas) from waste tires. The preliminary research was done on the three groups of samples acquired by cutting the same waste tire of a passenger vehicle into cylindrical granules with a base diameter of 3, 7, and 11 mm. Each batch weighed 10 g. The heating rate was 14 °C/min, and the final pyrolysis temperature was 750 °C, with 90 s residence time. After the pyrolysis product yields were determined for all of the three sample groups, further research was performed only on 3 mm granules, with the same heating rate, but with altered final pyrolytic temperatures (400, 450, 500, 550, 600, 650, 700, and 750 °C). The results of this study show that thermochemical decomposition of the waste tire sample takes place in the temperature range of 200–500 °C, with three distinct phases of degradation. The highest yield of the pyrolytic oil was achieved at a temperature of 500 °C, but further heating of volatile matters reduced the oil yield, and simultaneously increased the yield of gas, due to the existence of secondary cracking reactions. The analysis of pyrolytic oil and char showed that these products can be used as fuel.
26
Eby, D., and J. Woods. "LO38: Hypoglycemia is a rare peri-seizure finding in pre-hospital patients." CJEM 19, S1 (May 2017): S40—S41. http://dx.doi.org/10.1017/cem.2017.100.
Анотація:
Introduction: Conventional wisdom states that hypoglycemia is a frequent peri-seizure phenomenon and must be tested for. Conventional wisdom also lists hypoglycemia as a cause of seizures. Recent literature disputes this. Paramedic medical directives continue to direct paramedics to determine the blood sugar level on all seizure patients. The purpose of this study was to determine the frequency of hypoglycemia in patients identified as having “seizure” as the primary or final problem code in Ambulance Call Reports (ACRs) from a large regional paramedic base hospital program. Methods: We conducted a retrospective analysis of iMedic platform, electronic ACRs, for a 2 year period (Jan 01, 2014 to Dec 31, 2015), from 8 Paramedic Services serving a rural and urban population of 1.4 million. 5854 calls, had “seizure” listed as a primary or final problem code. A 10% sample was generated using a random number table. ACRs were manually searched, data abstracted onto spread sheets, and the results analyzed using descriptive statistics (Wizard ver 1.8.16 for Mac). Results: 582 calls were analyzed. 430 (73.9%) were adults and 152 (26.1%) were paediatric (age <18). A blood sugar was determined in 501/582 (86.1%) of all calls; adults 388/430 (90.2%), peadiatric 113/152 (74.3%). The Glasgow Coma Score, when measured, was 15 in 280/575 (48.7%) cases. Seizures were witnessed by paramedics in 47/582 (8.1%) calls; adults 33/430 (7.7%), paediatric 14/152 (9.2%). In calls were paramedics witnessed a seizure a blood sugar was determined 36/47 (76.6%) of the time; adults 25/33 (75.8%), paediatric 11/14 (78.6%). Hypoglycemia (BS<4.0 mmol/L in an adult and 3.0 mmol/L in child<age 2 ) was found in 1 case when BS was checked-overall 1/501 (0.2%); adults 1/388 (0.3%), paedatric 0/113 (0.0%). Case 1-age 70 yr, GCS 12, BS 3.8 mmol/L. Conclusion: Hypoglycemia was rarely found in patients who had a pre-hospital seizure. It did not require treatment. When it was found, hypoglycemia was unlikely to be the cause of the seizure. The results are similar to the findings from other recent, retrospective, reviews. The routine determination of blood sugars in all patients who have had a seizure prior to paramedic arrival should be reconsidered.
27
Smires, F. Z., A. Assaidi, M. A. Loriot, C. Moreau, R. Habbal, and S. Nadifi. "P101 Effect of different genetic variants (2C9*2, 2C9*3 of cytochrome P-450 CYP2C9 and −1639G>A of the VKORC1 gene) on acenocoumarol requirement in Moroccan patients." European Journal of Cardiovascular Nursing 10 (April 2011): S38. http://dx.doi.org/10.1016/s1474-5151(11)60135-7.
28
Růžek, L., K. Voříšek, J. Vráblíková, S. Strnadová, and P. Vráblík. "Chemical and biological characteristics of reclaimed soils in the Most ŕegion (Czecg Reooublic)." Plant, Soil and Environment 49, No. 8 (December 10, 2011): 346–51. http://dx.doi.org/10.17221/4135-pse.
Анотація:
Soil organic carbon content [Corg], pHH2O, pHKCl and microbiological characteristics (microbial biomass carbon [CMB], extracellular microbial carbon [CEX], respiration, ammonification, and nitrification) were studied in 11 reclaimed soils, where the technical reclamation was carried out by Most Coal Mining Company in the year 2000 or 2001. These soils were immediately sown with legumes and grasses. Corg content in soil was rather wide ranging between 0.15–4.82%. The lowest value was determined in loess applied in the year 2001 at the locality No. 6 Mine Most, and the highest one at the locality No. 5 Mine Most amended with pulp wastes and sewage sludge (400 t and 200 t per hectare, respectively). pHKCl was in the range: 5.1–7.4. Six indicators of microbial status and metabolic activity of living micro-organisms, were used for the evaluation of the reclamation technology, i.e. (1) μg CMB/g dry soil, (2) μg CEX/mg CMB, (3) ratio CMB/Corg in per cent (4), potential respiration with glucose, (5) potential ammonification with peptone, (6) potential nitrification with (NH4)2SO4. The best results were found in the locality No. 5 Mine Most (reclaimed in 2000) amended with pulp wastes and sewage sludge (400 t and 200 t per hectare, respectively). The lowest values characterised the locality No. 1 Mine Slatenice (reclaimed in 2000) with a high content of coal powder and the lowest pHKCl (5.1). The use of mycorrhizal inoculum SYMBIVIT resulted in a high biological activity in the locality No. 11 Mine ___ that was the best among soils reclaimed in 2001.
29
Tishkina, K. A. "“Comrade! What Have You Done for Western Front?”: Participation of Inhabitants of Siberia in Collecting Donations for Benefit of Workers’ and Peasants’ Red Army (1920)." Nauchnyi dialog, no. 11 (December 1, 2021): 482–501. http://dx.doi.org/10.24224/2227-1295-2021-11-482-501.
30
Moretz, Tim L., Jeff B. Riley, Elaine K. Jeter, Robin G. Sutton, David G. Bishop, John M. Kratz, and Fred A. Crawford. "The Course of D-dimers as Fibrinolytic Products Generated During Cardiopulmonary Bypass." Journal of ExtraCorporeal Technology 22 (1990): 53–56. http://dx.doi.org/10.1051/ject/199022s053.
Анотація:
D-dimers are the expressed degradation products of the lysis of fibrin. Fibrin monomers may normally occur during routine cardiopulmonary bypass (CPB); therefore, fibrinolysis could play a protective role. Serum D-dimer levels were observed at six events associated with routine CPB. An expected patient D-dimer level while heparinized would be <0.5 ug/ml showing that fibrin is not being formed. The majority of elevated D-dimer levels came at the termination of CPB when only one of twenty patients investigated showed a minimal DD level of <0.5. The other patients ranged from 0.5 to >8.0 ug/ml at termination of CPB. Event ACT DD Level Baseline 123+/-15 1.0+/-1.1 Post Sternotomy 1.6+/-1.9 5 min on CPB 497+/-95 1.6+/-2.3 Terminate CPB 432+/-84 5.1+/-2.8 Post Protamine 116+/-11 5.1+/-2.8 1 Hr. Post Op 4.9+/-3.0 ACT = mean activated clotting time +/- 1SD The last three event D-dimer levels were significantly greater than the D-dimer from the first three events (p<0.01) demonstrating that fibrinolysis may be a normal occurrence during CPB. The weak correlation in the rise in D-dimers during CPB versus the minimal CPB ACT data (n=20, r=.114) although not statistically significant, suggests that ACTs should be maintained above 480 seconds throughout CPB to minimize fibrin formation and therefore minimize fibrinolysis.
31
Park, Sung Hyun, Dong Seok Seo, and Jong Kook Lee. "Electrical Properties of Silver Paste Prepared from Nanoparticles and Lead-Free Frit." Journal of Nanoscience and Nanotechnology 7, no. 11 (November 1, 2007): 3917–19. http://dx.doi.org/10.1166/jnn.2007.059.
Анотація:
Recently, PbO containing glass systems in commercial silver paste have been used due to their low glass transition temperature, good thermal and electrical properties. However, PbO is a hazardous material to both health and the environment. In this study, Pb-free silver paste was prepared by mixing commercial silver powder and silver nanoparticles. The commercial powder has an average particle size of 1.6 μm. The silver nanoparticles with particles size of 20–50 nm were synthesized by a chemical reduction method using surfactant. Pb-free frit was added into the mixed silver powder as the amounts of 3, 6 and 9 wt%. Using the obtained paste, thick films were fabricated by a screen printing on alumina substrate and the films were fired at temperature from 400 to 550 °C. The films had thickness of 6–11 μm and sheet resistivity of about 4–11 μΩ cm.
32
Kawecki, A., D. R. Adkins, C. C. Cunningham, E. Vokes, D. M. Yagovane, G. Dombal, P. Koralewski, Y. Hotko, and V. Vladimirov. "A phase II study of ARQ 501 in patients with advanced squamous cell carcinoma of the head and neck." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 16509. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.16509.
Анотація:
16509 Background: ARQ 501 is a DNA damage checkpoint pathway activator whose effect is to induce selective cell death in cancer cells, independent of the tumor cell's p53 status. Current evidence implicates a rapid and sustained increase of the pro-apoptotic protein E2F-1 by ARQ 501 as the mechanism of action. Cancer cells are selectively affected due to their pre-existing DNA damage. In initial clinical trials, there was evidence of activity in some patients with head and neck cancer and pre-clinical investigations also supported this application. Therefore, a phase 2 trial is warranted in this patient population. Methods: A phase 2 study in patients with locally advanced, recurrent or metastatic squamous cell carcinoma of the head and neck who had received up to 3 prior systemic therapies was initiated to assess overall response rate, progression free survival at six months, and to further characterize safety. Cycles consist of four weekly administrations of ARQ 501 at a dose of 450 mg/m2. Dose escalation is allowed if a patient successfully completed a full cycle of therapy and had no related grade 2 adverse events. Results: 59 patients have been enrolled to date and 47 have received at least one infusion of ARQ 501. Data is available for 34 patients (27M / 7F, median age, 57 years). Of the 47 patients treated, 11 patients did not reach a post baseline assessment (2 deaths, 8 PD prior to week 8 and 1 withdrew consent). Although at the current date, most patients have not reached their first tumor evaluation, 5 have been assessed for response per RECIST at eight weeks and one patient is demonstrating stable disease. The drug has been well tolerated with the most common adverse event being anemia (11% ) with corresponding edema, fatigue (both 5%), dyspnea (4%), and hyperbilirubinemia (2%). Conclusions: ARQ 501 is well tolerated in patients with advanced, recurrent or persistent squamous cell carcinoma of the head and neck. Enrollment is ongoing and further results will be presented. No significant financial relationships to disclose.
33
Freire, Dolores E., Jeniffer D. Olaya, and Michael Hawkes. "1405. Clinical and laboratory features of fatal dengue fever in children: a case-control study." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S710—S711. http://dx.doi.org/10.1093/ofid/ofaa439.1587.
Анотація:
Abstract Background Dengue fever (DF) is a mosquito-borne illness that causes significant morbidity and mortality in tropical climates. This study compared the clinical features of fatal DF cases to severe non-fatal, and non-severe controls in Ecuador. Methods Retrospective case-control study of children (1 month to 15 years) hospitalized with serologically-confirmed DF in Guayaquil, Ecuador from 2013 to 2017. Cases of severe, fatal (SF) DF were compared to two control groups: (1) severe DF survivors (SS); and (2) patients with dengue with warning signs (DWS), matched 3:1 to cases for age, sex, and admission date. Observational trial profile Results 1051 patients were admitted with suspected DF and 552 were IgM-positive. Patients were classified as SF (n=11), SS (n=30), or DWS (n=511) (Figure1). Among SF cases, median age was 9.6 years (IQR 5.5-11), 7 (64%) were male, and median time to death was 1.5 days (IQR 0.8-4.0). (Table 1) SF cases had a median of 3 (Range 0-5) encounters with healthcare providers prior to presentation, compared to 2 (Range 0-5, p=0.02) for SS and 2 (Range 0-3, p=0.02) for DWS. Physical findings more common in SF cases than controls included: higher weight, tachycardia, tachypnea, delayed capillary refill, and hepatomegaly (p< 0.05 for all comparisons). Neurological manifestations were more prevalent in the SF group: 9/11 (82%) patients compared to 15/30 (50%, p=0.09) in SS and 7/33 (21%, p< 0.01) in DWS. Total leukocyte count (7.8x103/µL versus 4.5x103/µL, p=0.03) and absolute neutrophil count (5.1x103/µL versus 2.1x103/µL, p=0.03) were higher in SF cases than DWS controls. Fewer SF patients received intravenous dextrose than SS controls (27% versus 70%, p=0.03) (Table 2). Admission characteristics of children with dengue fever Management and outcome Conclusion Delayed recognition by healthcare workers, higher weight, vital sign abnormalities, hepatomegaly, neurological symptoms, leukocytosis, neutrophilia, and lack of dextrose in intravenous solutions were associated with mortality in children with DF. These findings have implications for optimizing the diagnosis and management of severe pediatric dengue infection. Disclosures All Authors: No reported disclosures
34
Di Lauro, L., S. I. Fattoruso, L. Giacinti, P. Vici, D. Sergi, and M. Lopez. "Second-line chemotherapy with FOLFIRI in patients with metastatic gastric cancer (MGC) not previously treated with fluoropyrimidines." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 4549. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4549.
Анотація:
4549 Background: No established second-line chemotherapy exists for patients (pts) with MGC failing to respond or progressing after first-line chemotherapy. This study was designed to determine the efficacy and safety of FOLFIRI combination used as second-line therapy in pts with MGC not previously treated with regimens containing fluoropyrimidines. Methods: Pts with measurable distant metastases, previously treated with a combination of epirubicin, docetaxel and cisplatin or oxaliplatin as first-line therapy, received irinotecan 180 mg/mq (150 mg/mq in pts >70 ys old) as a 1-h infusion day 1; leucovorin 100 mg/mq/day followed by bolus fluorouracil (FU) 400 mg/mq and a 22-h infusion of FU 600 mg/mq day 1–2, every 2 weeks for a maximum of 12 cycles or until disease progression, unacceptable toxicity or patients refusal. Endpoints were response rate (RR), time to progression (TTP), overall survival (OS) and safety. Results: 38 pts were enrolled: M/F 23/15; median age 66 ys (34–75); median ECOG PS 1 (0–2); number of metastatic sites 1/2/≥3: 9/18/11 pts, respectively. A total of 223 cycles was performed (median 6, range 2–12). One CR and 8 PR were observed for an overall RR of 24% (95% CI, 11–39 %). Disease remained stable in 11 pts. Median TTP was 4.0 months (95% CI, 2.9–5.1) and median OS was 6.2 months (95% CI, 4.7–7.7). Grade 3/4 neutropenia, thrombocytopenia and anemia occurred in 29%, 3% and 8% of pts, respectively. Febrile neutropenia was seen in 2 pts (5%). Other grade 3 toxicities included diarrhea in 5 pts (13%), mucositis in 2 pts (5%) and vomiting in 2 pts (5%). There were no treatment related deaths. Conclusions: FOLFIRI is an active and well tolerated second-line regimen for MGC pts not previously treated with fluoropyrimidines. No significant financial relationships to disclose.
35
Priyanka Chandel, Margaret Messiah Singh, Atanu Kumar Pati, and Arti Parganiha. "Exposure to radio-frequency electromagnetic radiation shortens sleep duration and lengthens sleep latency and sleep inertia in humans living in proximity to the base transceiver stations." South Asian Journal of Experimental Biology 11, no. 4 (August 9, 2021): 466–81. http://dx.doi.org/10.38150/sajeb.11(4).p466-481.
Анотація:
Radio-frequency electromagnetic radiations (RF-EMRs) are ubiquitous at present. Therefore, it is essential to assess the impact of RF-EMRs on human health. In this study, we examined the non-thermal effects of RF-EMR expo-sure on behavioral sleep patterns in humans. A total of 1072 randomly se-lected individuals living in the proximity of base transceiver stations (BTS) participated in the study. The sample consisted of 122 subjects from zone A (Inter-tower region), 310 from zone B (0-150 m), 316 from zone C (150-300 m), 197 from zone D (300-500 m), and 127 from the control zone (without BTS installations). We classified the zones as a function of distance from the BTS. We measured electric-field strength at each participant’s house using Narda Broadband Field Meter-550 equipped with EF0-391 probe. We used Munich-Chronotype Questionnaire to determine each subject’s behavioral sleep patterns. ANOVA results revealed the highest E-field strength in zone-A than the other zones and control. Results from ANCOVA, Kruskal-Wallis, and Mann-Whitney U tests showed that the participants from zone A had shorter sleep duration, and longer sleep latency and inertia than those living in other zones. Further, a significant effect of co-factors ‘gender’ and ‘year of resi-dence’ was validated on mid-sleep (work and free days). Compared to wom-en and > 5-year residents, men and 1-5-year residents had delayed mid-sleep. We concluded that RF-EMR might alter the behavioral sleep patterns of subjects living in the vicinity of BTS. However, further confirmatory and extensive studies are necessary, involving a large sample living near many more BTS installations.
36
Lohmander, L. S., M. Gerhardsson de Verdier, J. Rollof, P. M. Nilsson, and G. Engström. "Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study." Annals of the Rheumatic Diseases 68, no. 4 (May 8, 2008): 490–96. http://dx.doi.org/10.1136/ard.2008.089748.
Анотація:
Objective:To determine in a prospective population-based cohort study relationships between different measures of body mass and the incidence of severe knee and hip osteoarthritis defined as arthroplasty of knee or hip due to osteoarthritis.Materials and methods:Body mass index (BMI), waist circumference, waist–hip ratio (WHR), weight and percentage of body fat (BF%) were measured at baseline in 11 026 men and 16 934 women from the general population. The incidence of osteoarthritis over 11 years was monitored by linkage with the Swedish hospital discharge register.Results:471 individuals had knee osteoarthritis and 551 had hip osteoarthritis. After adjustment for age, sex, smoking and physical activity, the relative risks (RR) of knee osteoarthritis (fourth vs first quartile) were 8.1 (95% CI 5.3 to 12.4) for BMI, 6.7 (4.5 to 9.9) for waist circumference, 6.5 (4.6 to 9.43) for weight, 3.6 (2.6 to 5.0) for BF% and 2.2 (1.7 to 3.0) for WHR. Corresponding RR for hip osteoarthritis were 2.6 (2.0 to 3.4) for BMI, 3.0 (2.3 to 4.0) for weight, 2.5 (1.9 to 3.3) for waist, 1.3 (0.99 to 1.6) for WHR and 1.5 (1.2 to 2.0) for BF%.Conclusion:All measures of overweight were associated with the incidence of knee osteoarthritis, with the strongest relative risk gradient observed for BMI. The incidence of hip osteoarthritis showed smaller but significant differences between normal weight and obesity. Our results support a major link between overweight and biomechanics in increasing the risk of knee and hip osteoarthritis in men and women.
37
Peres, Maria, Manuela F. Almeida, Élia J. Pinto, Carla Carmona, Sara Rocha, Arlindo Guimas, Rosa Ribeiro, et al. "Implementing a Transition Program from Paediatric to Adult Services in Phenylketonuria: Results after Two Years of Follow-Up with an Adult Team." Nutrients 13, no. 3 (February 28, 2021): 799. http://dx.doi.org/10.3390/nu13030799.
Анотація:
We aimed to report the implementation of a phenylketonuria (PKU) transition program and study the effects of follow-up with an adult team on metabolic control, adherence, and loss of follow-up. Fifty-five PKU patients were analysed in the study periods (SP): 2 years before (SP1) and after the beginning of adult care (SP2). Retrospective data on metabolic control and number of clinic appointments were collected for each SP, and protein intakes were analysed. In SP2, three patients (6%) were lost to follow-up. There was a small but statistically significant increase in median number of annual blood spots from SP1 to SP2: 11 (7–15) vs. 14 (7–20); p = 0.002. Mean ± SD of median blood Phe remained stable (525 ± 248 µmol/L vs. 552 ± 225 µmol/L; p = 0.100); median % of blood Phe < 480 µmol/L decreased (51 (4–96)% vs. 37 (5–85)%; p = 0.041) and median number of clinic appointments increased from SP1 to SP2: (5 (4–6) vs. 11 (8–13); p < 0.001). No significant differences were found regarding any parameter of protein intake. Our results suggest that the implementation of an adult service was successful as impact on metabolic control was limited and attendance remained high. Continuous dietetic care likely contributed to these results by keeping patients in follow-up and committed to treatment.
38
Archana, B., P. Kotesh, Ramya Sree, Pole Nikhitha, Kursenga Santosh kumar, Shaik Afroz, and SK Jiyarul. "Antidiabetic Activity of Ethanolic Extract of Seed Kernel of Sapindus emarginatus in Rats." Journal of Drug Delivery and Therapeutics 12, no. 3-S (June 15, 2022): 15–25. http://dx.doi.org/10.22270/jddt.v12i3-s.5351.
Анотація:
Hyperglycemia is indeed a dyslipidemia across a Globe. An International Diabetes Federation (IDF) has Predicted a certain 366 million more people have diabetes in 2011 and it has been raised up to 552 million by 2050. It approximated a certain 40 million people of hyperglycemia through India in 2007 and yet this may predicted to grow almost to 70 million affected by 2025. LD50 study of the ethanolic extract of S. emarginatus seed kernel (EESESK) has been done throughout Albino rats up to a daily dosage constrain of 2000 mg/kg orally (according to OECD guidelines No.425 of CPCSEA) 1/5th, 1/10th dosage as from maximum dose examined for LD50 study results were again for experimental test research to examine a impact of S. emarginatus for a anti diabetes action. Insulin inefficiency was found in two selected model for my study. Alloxan hydrate at such a mg dosage of 150 mg/kg i.p after 48 hrs, the EESESK seed kernel it at a dosage of 200 mg/kg but also 400 mg/kg p.o have been administered. Dexamethasone 10 mg/kg, i.p, once daily. And at the inter of 30 mins EESESK 200 mg/kg and 400 mg/kg p.o had been conducted in rats for a period of 11 and 21 days respectively. At the end of the experimental, serum biomarkers such as glycogen, high cholesterol, triglycerides, LDL, HDL, and VLDL were analyzed by using semi-auto analyzer. In both models EESESK at a dose of 400 mg/kg exhibited substantial impact. Alloxan hydrate increased serum biochemical markers like glucose, high cholesterol, triglyceides, LDL, VLDL levels but decreased HDL levels. Dexamethasone caused an increase in serum glucose, High cholesterol and reduces High density lipopretein-cholesterol levels. The present study indicates that S.emarginatus seed kernel useful for the management of diabetes mellitus. S.emarginatus pollen seed found important reducing of glycogen TC, TG, LDL, VLDL levels and increased level of High Density Lipoprotein through diabetic concept mice. A enhanced high density lipoprotein is also Cardioprotective activity. Therefore S.emarginatus seed kernel must have future role to forestall forming of atherosclerosis but also cardiovascular disease.
Keywords: Antidiabetic activity, Ethanolic extract, Seed kernel and Rats
39
DevivaraPrasad, M., P. Subramaniyan, B. A. Praveen Kumar, and P. Janakiraman. "Prehypertension and Hypertension among School Teachers: An Epidemiological Study from South India." Medical Journal of Dr. D.Y. Patil Vidyapeeth 17, no. 2 (March 2024): 349–54. http://dx.doi.org/10.4103/mjdrdypu.mjdrdypu_379_23.
Анотація:
ABSTRACT Context: Teaching is regarded as one of the most stressful occupations, making them more vulnerable to cardiovascular diseases, especially hypertension. Aims and Objectives: We explored this study to estimate the prevalence of pre-hypertension and hypertension and its risk factors among school teachers. Settings and Design: This cross-sectional study was conducted for one year among 400 school teachers working in primary and secondary schools in southern Andhra Pradesh. Materials and Methods: Cluster sampling technique was used for sampling, where each school was considered as a cluster. A validated proforma with a questionnaire developed based on the WHO STEPS manual was used to collect data on socio-demographic details, blood pressure recordings, anthropometric measurements, and other related factors. Statistical Analysis: Odds ratio, the Chi-square test, and regression analysis was used to test the significance, where p < 0.05 was considered significant. Results: Among 400 subjects, 52.3% had normal blood pressure, 32.0% had pre-hypertension, and 15.7% had hypertension, with a total of pre-hypertension/ hypertension 47.7%. Prevalence of pre-hypertension/hypertension was significantly higher among the males (47.6%) [UOR: 2.4 (1.6-3.6)], the age group of 40 years and above (39.8%) [UOR: 4.6 (2.8-7.6)], and married subjects (90.1%) [UOR: 3.2 (1.8-5.6)]. Those who perceived moderate/severe stress at work (32.5%) [UOR: 3.9 (2.3-6.6)], teaching work of 11 years and above (59.7%) [UOR: 4.0 (2.7-6.2)], inadequate intake of fruits/vegetables (81.7%) [UOR: 1.6 (1.0-2.6)], adding extra salt to food (56.0%) [UOR: 2.0 (1.4-2.9)], and those who were overweight/obese (67.5%) [UOR: 3.4 (2.2-5.1)] had a higher prevalence. Conclusions: The prevalence of pre-hypertension and hypertension was considerably high among school teachers, and several factors were significantly associated with hypertension. Coordinated efforts in early diagnosis, control, and prevention of hypertension among teachers are the need of the hour.
40
Malik, K. J., K. Wakelin, S. Dean, D. H. Cove, and P. J. Wood. "Cushing's Syndrome and Hypothalamic-Pituitary Adrenal Axis Suppression Induced by Medroxyprogesterone Acetate." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 33, no. 3 (May 1996): 187–89. http://dx.doi.org/10.1177/000456329603300302.
Анотація:
The referral of a patient with features of Cushing's syndrome but with suppressed plasma cortisol and adrenocorticotrophic hormone concentrations prompted us to study the effect of medroxyprogesterone acetate (MPA) therapy on the adrenal axis. 11 women (aged 54–82 years) who were receiving 200–400 mg/day MPA were studied. Of these, four had subnormal plasma cortisol responses to a short synacthen test, and two more had borderline responses (30 min post-synacthen plasma cortisol results of 411 and 511 nmol/L). We conclude that suppression of the adrenal axis occurs relatively frequently in patients on MPA and that such patients should be checked for evidence of suppression before MPA therapy is withdrawn.
41
Dutta, Koushik, Ravi Bhushan та B. L. K. Somayajulu. "ΔR Correction Values for the Northern Indian Ocean". Radiocarbon 43, № 2A (2001): 483–88. http://dx.doi.org/10.1017/s0033822200038376.
Анотація:
Apparent marine radiocarbon ages are reported for the northern Indian Ocean region for the pre-nuclear period, based on measurements made in seven mollusk shells collected between 1930 and 1954. The conventional 14C ages of these shells range from 693 ± 44 to 434 ± 51 BP in the Arabian Sea and 511 ± 34 to 408 ± 51 BP in the Bay of Bengal. These ages correspond to mean ΔR correction values of 163 ± 30 yr for the northern Arabian Sea, 11 ± 35 yr for the eastern Bay of Bengal (Andaman Sea) and 32 ± 20 yr for the southern Bay of Bengal. Contrasting reservoir ages for these two basins are most likely due to differences in their thermocline ventilation rates.
42
Pakki, Syahrir, and Mappaganggang Mappaganggang. "Resistance Response of Maize Germplasm to Downy Mildew [Peronosclerospora philipinensis]." Buletin Plasma Nutfah 24, no. 1 (October 17, 2018): 43. http://dx.doi.org/10.21082/blpn.v24n1.2018.p43-52.
Анотація:
<p>Two experiments to study responses of resistance of maize germplasm to downy mildew (Peronosclerospora philipinensis) have been conducted. Both experiments were arranged in randomized block design with two replication. The treatments in each experiment (2014 and 2016) were 70 maize accessions. The accessions were planted in planting distant of 75 cm × 20 cm, in 5 m rows, resulting in 20 plants per row. In every 10 rows, two check varieties were planted, i.e. one susceptible and one resistant variety. Ten days prior to planting, the soil was fertilized with mixed fertilizers consisted of urea, ZA, SP36, and KCl at a dose of 100, 100, 100, and 100 kg/ha, respectively. Fertilization II and III was given at 30 days after planting, and 45 days after planting with a dose of 100 kg urea/ha. As a source of inoculum downy mildew, around the repeated plot was planted with varieties Anoman variety (susceptible variety) that was inoculated with a suspension of downy mildew pathogen. Observation was conducted at 25, 35, and 55 days after planting, with the standard score of resistant to downy mildew, followed: 0–10% = resistant, 11–25% = moderately resistant, 26–50% = moderately susceptible, >50% = susceptible. The result of the experiments showed that there were 5 accessions resistant to downy mildew (P. philipinensis), i.e. CML 440×MR4-9-30-3, 664, 60, 572, and 554 with the intensity of downy mildew infection ranged from 5 to 10%. Twelve other accessions were classified as moderately resistant, i.e. CML 440×MR4-9-98-2, 440×MR4-9-98-4 CML, CML 440×MR4-9-124-1, 66, 71, 319, 108, 73, 48, 105, 554, and 682 with intensity of infection ranged from 13 to 25%. At the same experiments, the average intensity of downy mildew infection on susceptible check varieties reached 100 percent.</p>
43
Moretz, Tim L., Jeff B. Riley, Elaine K. Jeter, Robin G. Sutton, David G. Bishop, John M. Kratz, and Fred A. Crawford. "The Course of D-Dimers as Fibrinolytic Products Generated During Cardiopulmonary Bypass." Journal of ExtraCorporeal Technology 22, no. 3 (September 1990): 131–35. http://dx.doi.org/10.1051/ject/1990223131.
Анотація:
D-Dimers are the expressed degradation products of the lysis of fibrin. Fibrin monomers may normally occur during routine cardiopulmonary bypass (CPB); therefore, fibrinolysis could play a protective role. Serum D-dimer levels were observed at six events associated with routine CPB. An expected patient D-dimer level while heparinized would be <0.5 mcg/ml showing that fibrin is not being formed. The majority of elevated D-dimer levels came at the termination of CPB when only one of twenty patients investigated showed a minimal D-dimer level of <0.5. The other patients ranged from 0.5 to >8.0 ug/ml at termination of CPB. Table A Event samples with respective ACT and D-Dimer Event ACT DD Level Baseline 123 ± 15 1.0 ± 1.1 Post Sternotomy 1.6 ± 1.9 5 min. on CPB 497 ± 84 1.6 ± 2.3 Terminate CPB 432 ± 84 5.1 ± 2.8 Post Protamine 116 ± 11 5.1 ± 2.8 1 Hr. Post Op 4.9 ± 3.0 ACT = mean activated clotting time ± 1SD The last three event D-dimer levels were significantly greater than the D-dimer from the first three events (p<0.01) demonstrating that fibrinolysis may be a normal occurrence during CPB. The weak correlation in the rise in D-dimers during CPB versus the minimal CPB ACT data (n=20, r=.114) although not statistically significant, suggests that ACTs should be maintained above 480 seconds throughout CPB to minimize fibrin formation and therefore minimize fibrinolysis.
44
Lin, Kuo-Chih, Huei-Lan Chang, and Ruey-Yi Chang. "Accumulation of a 3′-Terminal Genome Fragment in Japanese Encephalitis Virus-Infected Mammalian and Mosquito Cells." Journal of Virology 78, no. 10 (May 15, 2004): 5133–38. http://dx.doi.org/10.1128/jvi.78.10.5133-5138.2004.
Анотація:
ABSTRACT Japanese encephalitis virus (JEV) contains a single positive-strand RNA genome nearly 11 kb in length and is not formally thought to generate subgenomic RNA molecules during replication. Here, we report the abundant accumulation of a 3′-terminal 521- to 523-nucleotide (nt) genome fragment, representing a major portion of the 585-nt 3′ untranslated region, in both mammalian (BHK-21) and mosquito (C6/36) cells infected with any of nine strains of JEV. In BHK-21 cells, the viral genome was detected as early as 24 h postinfection, the small RNA was detected as early as 28 h postinfection, and the small RNA was 0.25 to 1.5 times as abundant as the genome on a molar basis between 28 and 48 h postinfection. In C6/36 cells, the genome and small RNA were present 5 days postinfection and the small RNA was 1.25 to 5.14 times as abundant as the genome. The 3′-terminal 523-nt small RNA contains a 5′-proximal stable hairpin (nt 6 to 56) that may play a role in its formation and the conserved flavivirus 3′-cyclization motif (nt 413 to 420) and the 3′-terminal long stable hairpin structure (nt 440 to 523) that have postulated roles in genome replication. Abundant accumulation of the small RNA during viral replication in both mammalian and mosquito cells suggests that it may play a biological role, perhaps as a regulator of RNA synthesis.
45
Avila, A., A. Rodrigo, and F. Rodà. "Nitrogen circulation in a Mediterranean holm oak forest, La Castanya, Montseny, northeastern Spain." Hydrology and Earth System Sciences 6, no. 3 (June 30, 2002): 551–58. http://dx.doi.org/10.5194/hess-6-551-2002.
Анотація:
Abstract. The importance of storm frequency as well as the groundwater and hyporheic inputs on nitrate (NO3-N) and ammonium (NH4-N) levels in stream water were studied in a small perennial Mediterranean catchment, Riera Major, in northeast Spain. NO3-N concentrations ranged from 0.15 to 1.9 mg l-1. Discharge explained 47% of the annual NO3-N concentration variance, but this percentage increased to 97% when single floods were analysed. The rate of change in nitrate concentration with respect to flow, ΔNO3-N/ΔQ, ranged widely from 0 to 20 μg NO3-N s l-2. The ΔNO3-N/ΔQ values fitted to a non linear model with respect to the storm flow magnitude (ΔQ) (r2=0.48, d.f.=22, P<0.01). High values of ΔNO3-N/ΔQ occurred at intermediate ΔQ values, whereas low ΔNO3-N/ΔQ values occurred during severe storms (ΔQ > 400 l s-1). N3-N concentrations exhibit anticlockwise hysteresis patterns with changing flow and the patterns observed for autumnal and winter storms indicated that groundwater was the main N3-N source for stream and hyporheic water. At baseflow, NO3-N concentration in groundwater was higher (t=4.75, d.f.=29, P>0.001) and co-varied with concentrations in the stream (r=0.91, d.f.=28, P<0.001). In contrast, NO3-N concentration in hyporheic water was identical to that in stream water. The role of the hyporheic zone as source or sink for ammonium was studied hyporheic was studied comparing its concentrations in stream and hyporheic zone before and after a major storm occurred in October 1994 that removed particulate organic matter stored in sediments. Results showed high ammonium concentrations (75±28 s.d. μg NH4-N l-1) before the storm flow in the hyporheic zone. After the storm, the ammonium concentration in the hyporheic dropped by 80% (13.6±8 μg N4-N l-1) and approached to the level found in stream water (11±8 μg NH4-N l-1) indicating that indisturbed hyporheic sediments act as a source for ammonium. After the storm, the ammonium concentrations in the stream, hyporheic and groundwater zones were very similar suggesting that stream ammonium concentrations are sustained mainly by input from groundwater. The present study provides evidence that storm flow magnitude is an important source of variability of nitrate concentration and fluxes in Mediterranean streams subjected to an irregular precipitation regime with prolonged dry periods. Keywords: nitrate, discharge regime, hyporheic zone, groundwater, Mediterranean, stream, Riera Major
46
Zhu, Xinhua, Yong Zhou, Yuzi Zhang, and Shangli Cai. "Genomic somatic alterations of human epidermal growth factor-2 (HER2) gene: A pan-cancer analysis." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 3112. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3112.
Анотація:
3112 Background: Human epidermal growth receptor 2 (HER2) is a well-known oncogenic drive gene with multiple targeted therapeutic options. In this study, we aim to assess the landscape of HER2 alterations in solid tumors and evaluate the feasibility of circulating tumor DNA (ctDNA) tested by next-generation sequence (NGS) as a tool to detect HER2 alterations. Methods: Alterations of HER2 by NGS (Illumina NextSeq 500) were queried in 3D Medicines database. The mean depth of tissue and circulating tumor DNA (ctDNA) test was 500X and 5000X, respectively. 11,013 patients tested using tumor tissue and 6,970 patients tested using ctDNA were included in this analysis. Results: Of 11,013 patients tested using tumor tissue, any HER2 and known or likely deleterious HER2 mutations were identified in 739 (6.7%) and 531 (4.8%) patients, respectively. Of 531 patients who carried known or likely deleterious HER2 mutations, 263 (49.5%) had HER2 amplification and 259 (48.8%) had single nucleotide variations (SNVs). Across all tumor types, breast cancer was found to have the highest frequency of HER2 amplification (14.9%, 48/323), followed by gastric cancer (6.6%, 31/470) and biliary tract cancer (5.8%, 33/571). Moreover, 11% (8/73) of duodenal cancer, 4.5% (7/154) of urothelial cancer, 3.8% (18/470) of gastric cancer, 3.1% (142/4555) of lung cancer, 2.9% (17/571) of biliary tract cancer, 2.8% (44/1562) of colorectal cancer and 2.7% (9/323) of breast cancer carried known or likely deleterious HER2 SNVs. Of 6970 patients tested using ctDNA, any HER2 and known or likely deleterious HER2 mutations were identified in 592 (8.5%) and 277 (4.0%) patients, respectively. In the ctDNA cohort, 15.7% (36/230) of breast cancer and 3.1% (5/161) of biliary tract cancer carried HER2 amplification. However, 11.6% (20/173) of gastric cancer had HER2 amplification tested by ctDNA which was higher than that tested using tissue. Furthermore, 5.6% (13/230) of breast cancer, 4.5% (2/44) of urothelial cancer, 3.4% (6/173), 2.5% of biliary tract cancer and 2.0% (94/4586) lung cancer harbored known or likely deleterious HER2 SNVs in ctDNA cohort. Conclusions: HER2 alterations existed across tumor types and the landscape of genomic alterations in HER2 gene varied according to different type of tumor. In addition, ctDNA can be used as a potential tool to detect HER2 alterations.
47
Ndife, B., B. Hoskin, and N. Booth. "POS0104 ESSDAI AND ITS ASSOCIATION WITH PATIENT OUTCOMES IN SJÖGREN’S SYNDROME: A REAL-WORLD SURVEY IN THE US." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 263.1–263. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3807.
Анотація:
Background:The EULAR Sjögren’s syndrome disease activity index (ESSDAI) is considered the gold standard for measuring Sjögren’s syndrome disease activity in clinical trials, but there is limited evidence of its application in the real-world.Objectives:To describe the distribution of ESSDAI scores in the real-world and it’s association with patient outcomes.Methods:Data were drawn from the Adelphi Primary Sjögren’s syndrome (pSS) Disease Specific Programme™, a real-world point-in-time survey of rheumatologists and their consulting pSS patients in the United States. Proxy ESSDAI scores were calculated for each patient by assigning a score to the rheumatologists’ perception of “not present”, “mild”, “moderate” or “severe” for each of the twelve domains of the ESSDAI. ESSDAI scores were then grouped according to the definitions of mild (ESSDAI 0-4), moderate (ESSDAI 5-13) and severe (ESSDAI ≥14). Rheumatologists provided data about patient demographics and clinical characteristics. Patients self-completed patient reported outcome (PRO) tools including the EuroQol 5-dimension 5-level utility score (EQ-5D), Work Productivity and Activity Impairment questionnaire (WPAI) and The Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT-F). Differences in clinical characteristics and patient-reported outcomes were examined according to ESSDAI severity score. Spearman’s Rho association was used to assess the correlation of ESSDAI severity with PROs.Results:Rheumatologists (n=84) provided data for 511 pSS patients, mean age 53.3 years, 88.5% female, 79.8% white/Caucasian and mean time since diagnoses 4.6 years. Of the 511 patients, 44.2% were considered to be mild, 30.9% moderate and 24.9% severe in terms of their calculated ESSDAI score. Demographic characteristics of the three ESSDAI groups were similar, Table 1. Patients with severe ESSDAI scores have been diagnosed with pSS for longer than those with mild or moderate ESSDAI scores.Increasing ESSDAI severity was associated with worse EQ-5D utility scores (rho=-0.346, p<0.0001), worse FACIT-F scores (rho=-0.277, p<0.0001) and worse overall work impairment (rho=0.462, p<0.0001).Table 1.Demographic characteristics of pSS patients in the US, by ESSDAI severityTotal(n=511)Mild ESSDAI(n=226)Moderate ESSDAI(n=158)Severe ESSDAI(n=127)Patient age, mean (SD) years53.3 (14.2)52.6 (15.0)53.6 (14.0)54.2 (12.9)% (n) female88.5 (452)89.4 (226)88.6 (158)86.6 (127)Ethnicity, % (n)White/Caucasian79.8 (408)86.3 (195)74.7 (118)74.8 (95)African-American9.2 (47)6.2 (14)10.1 (16)13.4 (17)Hispanic/Latino6.1 (31)5.3 (12)8.2 (13)4.7 (6)Other4.9 (25)2.2 (5)7.0 (11)7.1 (9)Time since diagnosis, mean (SD) years [n]4.6 (5.4) [379]4.0 (4.9) [162]4.9 (5.6) [118]5.1 (5.8) [99]Insurance type, % (n)Commercial (including employer provided)59.9 (306)62.4 (141)56.3 (89)59.8 (76)Medicare20.5 (105)18.1 (41)23.4 (37)21.3 (27)Health insurance exchange plan9.6 (49)10.2 (23)10.1 (16)7.9 (10)Other9.6 (49)8.8 (20)9.5 (15)11.0 (14)None- (2)- (1)- (1)- (0)Employment status, % (n)Working full or part time58.9 (301)61.9 (140)53.2 (84)60.6 (77)Long-term sick/unemployed/retired24.5 (125)20.8 (47)27.2 (43)27.6 (35)Homemaker12.7 (65)10.2 (23)17.1 (27)11.8 (15)Other/unknown3.9 (20)7.1 (16)2.5 (4)- (0)Smoking status, % (n) current smoker6.8 (35)3.5 (8)5.7 (9)14.2 (18)Conclusion:A worsening severity on the ESSDAI scale is associated with worse outcomes for patients in the real-world. Treating systemic disease beyond symptomatic treatments is important to improve patient outcomes.Disclosure of Interests:Briana Ndife Shareholder of: Novartis Pharmaceuticals Corp, Employee of: Novartis Pharmaceuticals Corp, Ben Hoskin: None declared, Nicola Booth: None declared
48
Hartner, L. P., L. Rosen, M. Hensley, D. Mendelson, A. P. Staddon, W. Chow, O. Kovalyov, et al. "Phase 2 dose multi-center, open-label study of ARQ 501, a checkpoint activator, in adult patients with persistent, recurrent or metastatic leiomyosarcoma (LMS)." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 20521. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.20521.
Анотація:
20521 Background: ARQ 501 selectively induces apoptosis in cancer cells by inducing a rapid and sustained increase of the pro- apoptotic protein E2F-1. ARQ 501 has been studied in three phase 1 studies, demonstrating acceptable toxicity and encouraging signs of efficacy. A 54 y/o female with metastatic LMS who failed 7 previous therapies achieved a prolonged PR on ARQ 501 monotherapy. This was consistent with preclinical data, where induction of E2F-1 and corresponding efficacy in human leiomyosarcoma xenografts was observed. Methods: A phase 2 study in adult LMS patients (>3 prior systemic therapies) was initiated to assess ORR, TTP and further characterize the safety of ARQ 501. ORR included CR, PR and SD=4 mo. Four week cycles (ARQ 501 450mg/m2) were repeated until progression, unacceptable toxicity, or another discontinuation criterion. Results: 49 patients were enrolled and 45 received ARQ 501. Data is available for 43 patients (4M/39F, median age, 54). Of the 43, 10 did not reach a protocol defined tumor assessment (4 deaths, 5 PD and 1 lost to follow-up prior to week 8), 19 have been assessed for response per RECIST at eight weeks (7 SD of 8–28+ weeks, 1 PR, 11 PD) and 14 active patients yet to reach first tumor assessment. The most common AEs were: anemia (68%, 21%=G3), hyperbilirubinemia (35%, 6%=G3), fatigue (35%, 0%=G3), nausea (30%, 0%=G3), constipation (24%), hemolysis (21%, 6%=G3), dyspnea (21%), and vomiting (21%). One treatment related death was reported in a 47 y/o Asian male with severe hemolysis following a single infusion of ARQ 501 at 450 mg/m2. The pt was hospitalized, but severe hemolysis led to acute renal failure and the patient expired after 4 days. Conclusions: ARQ 501 was administered to 45 patients with advanced, recurrent or persistent leiomyosarcoma. Several patients have achieved some clinical benefit (1 PR, 3 prolonged SD), further analysis of efficacy data is warranted prior to additional clinical investigation. No significant financial relationships to disclose.
49
Cherniuk, Hanna, Ihor Kasiianyk, Boris Matviychuk, and Olha Matuz. "ASSESSMENT OF HUMIDIFICATION OF THE TERRITORY OF VINNITSA REGION BY THE RATIO OF PRECIPITATION AND EVAPORABILITY." SCIENTIFIC ISSUES OF TERNOPIL VOLODYMYR HNATIUK NATIONAL PEDAGOGICAL UNIVERSITY. SERIES: GEOGRAPHY 52, no. 1 (May 30, 2022): 38–43. http://dx.doi.org/10.25128/2519-4577.22.1.5.
Анотація:
The article contains information on the results of the analysis of the distribution of atmospheric precipitation and humidification in the Vinnytsia region. Vinnytsia region is located in the forest-steppe zone, but belongs to an area with unstable humidification with a high probability of dry years. Both in wet and dry years, the amount of precipitation increases from east to west towards the Carpathians.
To show the patterns of precipitation distribution, published sources and reference books on climate with normative indicators for precipitation for 45 points of the Vinnitsa region were analyzed. The humidification coefficient was calculated in relation to annual precipitation to evaporability.
Analysis of the geographical distribution of precipitation and humidification showed their dependence on relief, orohydrography and exposure of slopes. At altitudes less than 100 m (in the Dniester river valley), the amount of precipitation is 480-490 mm per year and the humidification coefficient is 0.60-0.62, and on windward slopes they increase to 517-520 mm and 0.62-0.64, respectively. On vistas of 100-150 m, the amount of precipitation increases to 504-520 mm and humidification to 0.63-0.65. For heights of 150-200 m, the average precipitation for the year is 500-510 mm and the humidification coefficient is 0.64. Most observation points are located at absolute altitudes from 200 to 300 m. At altitudes of 200-250 m, the amount of precipitation and humidification increases to 490-520-540-560 mm per year and 0.62-0.67-0.70-0.76. At altitudes of 250-275 m, precipitation amounts to 485-505-530-550 mm per year and humidification coefficients 0.63-0.66-0.73-0.75. The largest values of average annual precipitation and humidification coefficients are observed at altitudes of 275-300 and more than 300 m (510-540-550-560-570 mm and 0.65-0.72-0.76-0.77).
The northern territory of the region is located in the zone of optimal humidification of typical forest-steppes. Most of the territory is located in the zone of insufficient humidification (less than 0.7-0.65). A coefficient of insufficient humidification typical of the steppe zone (0.65-0.60) is determined for 16 points in areas south of the latitude of the cities of Gaisin and. Mooded Kurilovtsy. In a warm season, there are 3-5 periods without rains lasting 10-11 days. In 25% of cases, the duration of idle periods increases to 11-20 days, in 5% - to 21-30 days and 1-3% cases to 30-50 days or more.
Thus, the largest amount of precipitation (525-560 mm on average per year) falls in the north and northeast within the Dnieper Upland. In the South Bug Valley, annual rainfall decreases from northwest to southeast to 520-490 mm. On the Podolsk Upland and Vinnytsia Transnistria, the amount of precipitation varies from 500-550 mm per year on watersheds to 490-480 mm in river valleys. In most of the territory south of the latitude of Vinnitsa, humidification is insufficient, and south of the latitude of Gaisin, the humidification coefficient is the same as in the steppe zone (0.64-0.60).
Keywords: Vinnytsia region, climate, humidification coefficient, precipitation, distribution.
50
Dravecký, Miroslav, Boris Maderič, Ján Kicko, Štefan Danko, Dušan Karaska, Jozef Mihók, and Zuzana Guziová. "Reproductive success, selected nest characteristics and the effectiveness of establishing protection zones of the lesser spotted eagle (Aquila pomarina) population in Slovakia." Slovak Raptor Journal 9, no. 1 (June 30, 2015): 127–45. http://dx.doi.org/10.1515/srj-2015-0010.
Анотація:
Abstract In 2011–201 4 monitoring of the lesser spotted eagle (Aquila pomarina) breeding population was conducted in eight special protection areas in Slovakia. From a total of 272 successful breeding attempts by 1 49 breeding pairs during 4 breeding seasons 277 young birds were fledged. The average reproductive success ratio was thus 0.51 juv./pair present, 0.69 juv./breeding pair and 1 .37 juv./1 00 km2. In the surveyed period a total of 1 51 protection zones were established around the nests in 11 9 breeding territories, which provided protection for 1 7% of the breeding population of the lesser spotted eagle in Slovakia. By testing the effectiveness of protection zones it was determined that in nests with an established protection zone the probability of successful raising of young is higher in comparison with nests without such a zone. The probability that breeding will be successful in the nests of breeding pairs without a protection zone was 48.1% (95% confidence intervals (CIs): 37.4–59.0%), and in nests with a protection zone 64.8% (95% CIs: 59.8–69.6%). Among the five most frequent nest tree species used by A. pomarina in Slovakia for breeding are Picea abies 61 × (28.4%), Pinus sylvestris 45× (20.9%), Quercus sp. 36× (1 6.7%), Fagus sylvatica 25× (11 .6%) and Abies alba 1 8× (8.4%). Among the rarer nest tree species used are Larix decidua 1 2× (5.6%) and Alnus glutinosa 3× (1 .4%), while a further 11 species of nest trees did not achieve even 1%. The highest number of nest trees (n = 21 5), i.e. 34 nests (1 5.8%), was found in the altitude range of 401–450 m a.s.l. and 29 nests (1 3.5%) at 351–400 m a.s.l. Other altitude zones were all below the 1 0% mark. A total of 54% of nests found (11 6 nests) are located in the altitude zone of 301–600 m a.s.l., and 71 nests (33%) in the zone 600–900 m a.s.l. The lowest situated nest was at an altitude of 1 50 m and the highest at 950 m; the average was 595.01 m a.s.l. The highest number of nests (n = 209) were located on trees in a range 1 5.1–20.0 m above the ground (n = 92, 44%), while the lowest nest found was at a height of 5 m and the highest at 30 m above the ground.