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Статті в журналах з теми "547.055 22":
1
Hulin, Cyrille, Thierry Facon, Chaim Shustik, Andrew Belch, Maria Teresa Petrucci, Ulrich Dührsen, Jin Lu, et al. "Effect of Age on Efficacy and Safety Outcomes in Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM) Receiving Lenalidomide and Low-Dose Dexamethasone (Rd): The First Trial." Blood 124, no. 21 (December 6, 2014): 81. http://dx.doi.org/10.1182/blood.v124.21.81.81.
Анотація:
Abstract Background: In the pivotal FIRST trial, a randomized, international, multicenter phase 3 study, continuous Rd compared with melphalan-prednisone-thalidomide (MPT) improved progression-free survival (PFS) which was the primary endpoint (HR = 0.72; P < 0.01). The interim overall survival (OS) analysis showed a 22% reduction in risk of death with continuous Rd vs. MPT (HR = 0.78; P = 0.02) (Facon, Blood 2013). This analysis evaluates outcomes based on age, which was a stratification parameter, and compared pts aged ≤ 75 yrs and > 75 yrs. Methods: Pts with NDMM were randomized to continuous Rd until progressive disease (PD) (N = 535); 18 cycles (72 weeks [wks]) of Rd (Rd18; N = 541); or 12 cycles (72 wks) of MPT (N = 547). Starting doses were reduced in pts aged > 75 yrs: dexamethasone (20 vs. 40 mg), melphalan (0.20 vs. 0.25 mg/kg), and thalidomide (100 vs 200 mg). The primary endpoint was PFS (continuous Rd vs. MPT) and the secondary endpoint were OS, overall response rate, time to response, duration of response, time to Tx failure, time to 2nd AMT, health-related quality of life, safety. Results: The proportion of pts aged > 75 yrs was > 34% across treatment (Tx) arms. In pts ≤ 75 yrs, 37% had ISS stage III vs. 51% in > 75 yrs. ECOG score ≥ 1 was observed in 74% and 69% of pts aged > 75 and ≤ 75 yrs, respectively. Severe renal impairment (CrCl < 30 mL/min) was observed in 14% of pts > 75 vs. 7% in ≤ 75 yrs. PFS and OS outcomes favored continuous Rd over MPT in both age groups. With a median follow-up of 37 months (mos), PFS was 27.4 mos in continuous Rd pts vs. 21.8 mos in MPT pts aged ≤ 75 yrs (HR = 0.68; P < 0.001); a trend for improved PFS was also seen for pts aged > 75 yrs (HR = 0.81; P = 0.11) (Table 1). PFS for continuous Rd vs. Rd18 pts was also increased in both age groups (HR = 0.68; P < 0.001 and HR = 0.75; P = 0.03, respectively). Response rates were consistently higher with continuous Rd vs. MPT in pts aged ≤ 75 yrs (77% vs. 66%; P < 0.001) and > 75 yrs (71% vs. 55%; P < 0.001). Duration of response with continuous Rd was longer vs. MPT in pts aged ≤ 75 yrs (40 vs. 22 mos) and pts > 75 yrs (31 vs. 24 mos). The interim analysis of OS showed an improved trend for continuous Rd vs. MPT in pts aged ≤ 75 yrs (HR = 0.77; P = 0.06) and > 75 yrs (HR = 0.80; P= 0.16). Grade 3–4 adverse events (AEs) in ≥ 10% of pts were similar across age subgroups (Table 2). Tx discontinuation due to AEs was comparable across the Tx groups and independent of age. Conclusions:Regardless of age (≤ 75 vs. > 75 yrs), continuous Rd was effective, increased PFS and interim OS, and was generally well tolerated vs. MPT in NDMM pts. Duration of response was improved with continuous Rd vs. MPT and Rd18, irrespective of age, and with a more profound benefit observed in younger pts. Continuous Rd represents a new clinical option and standard of care for these pts in the first-line setting. Abstract 81. Table 1 PFS, OS and Response Aged ≤ 75 yrs Aged > 75 yrs All pts ITT population Continuous Rd (n = 349) Rd18 (n = 348) MPT (n = 359) Continuous Rd (n = 186) Rd18 (n = 193) MPT (n = 188) Continuous Rd (n = 535) Rd18 (n = 541) MPT (n = 547) Median PFS, mos 27.4 21.3 21.8 21.2 19.4 19.2 25.5 20.7 21.2 PFS HR (95% CI); P-value Continuous Rd vs. Rd18 0.68 (0.55–0.83); P < 0.01 0.75 (0.58–0.98); P = 0.03 0.70 (0.60–0.82); P < 0.01 Continuous Rd vs. MPT 0.68 (0.56–0.83); P < 0.01 0.81 (0.62–1.05); P = 0.11 0.72 (0.61–0.85); P < 0.01 4-yr OS, % 66 61 58 47 47 39 59 56 51 OS HR (95% CI); P-value Continuous Rd vs. Rd18 0.88 (0.67–1.16); P = 0.36 0.94 (0.69–1.29); P = 0.70 0.90 (0.73–1.10); P = 0.31 Continuous Rd vs. MPT 0.77 (0.59–1.01); P = 0.06 0.80 (0.59–1.09); P = 0.16 0.78 (0.64–0.96); P = 0.02 Response rate (≥ PR), % 77 77 66 71 66 55 75 73 62 Duration of response (≥ PR), mos 40 23 22 31 20 24 35 22 22 CI, confidence interval; ITT, intent to treat; PR, partial response. Table 2 Grade 3–4 AEs Observed in ≥ 10% of Pts Aged ≤ 75 yrs Aged > 75 yrs Safety population, % Continuous Rd (n = 347) Rd18 (n = 348) MPT (n = 357) Continuous Rd (n = 185) Rd18 (n = 192) MPT (n = 184) Neutropenia 28 25 47 28 29 40 Thrombocytopenia 8 9 13 9 7 7 Anemia 18 12 20 19 23 17 Leukopenia 5 6 11 4 5 8 Infections 29 21 16 29 23 20 DVT and/or PE 10 6 8 7 8 4 Peripheral sensory neuropathy 1 1 10 1 0 8 Tx discontinuation due to AEs 28 18 28 32 25 30 DVT, deep-vein thrombosis; PE, pulmonary embolism. Disclosures Hulin: Celgene: Honoraria. Off Label Use: Lenalidomide used in newly diagnosed multiple myeloma patients. Facon:Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Belch:Janssen, Celgene, Onyx: Honoraria. Petrucci:Celgene, Janssen-Cilag, Sanofi, Bristol-Myers Squibb: Honoraria. Dührsen:Celgene: Honoraria, Research Funding. Song:Celgene: Consultancy, Honoraria, Research Funding. Houck:Celgene: Employment. Chen:Celgene: Employment. Ervin-Haynes:Celgene: Employment.
2
Sergeev, V. A., K. Liou, P. T. Newell, S. I. Ohtani, M. R. Hairston, and F. Rich. "Auroral streamers: characteristics of associated precipitation,convection and field-aligned currents." Annales Geophysicae 22, no. 2 (January 1, 2004): 537–48. http://dx.doi.org/10.5194/angeo-22-537-2004.
Анотація:
Abstract. During the long-duration steady convection activity on 11 December 1998, the development of a few dozen auroral streamers was monitored by Polar UVI instrument in the dark northern nightside ionosphere. On many occasions the DMSP spacecraft crossed the streamer-conjugate regions over the sunlit southern auroral oval, permitting the investigation of the characteristics of ion and electron precipitation, ionospheric convection and field-aligned currents associated with the streamers. We confirm the conjugacy of streamer-associated precipitation, as well as their association with ionospheric plasma streams having a substantial equatorward convection component. The observations display two basic types of streamer-associated precipitation. In its polewardmost half, the streamer-associated (field-aligned) accelerated electron precipitation coincides with the strong (≥2–7μA/m2) upward field-aligned currents on the westward flank of the convection stream, sometimes accompanied by enhanced proton precipitation in the adjacent region. In the equatorward portion of the streamer, the enhanced precipitation includes both electrons and protons, often without indication of field-aligned acceleration. Most of these characteristics are consistent with the model describing the generation of the streamer by the narrow plasma bubbles (bursty bulk flows) which are contained on dipolarized field lines in the plasma sheet, although the mapping is strongly distorted which makes it difficult to quantitatively interprete the ionospheric image. The convective streams in the ionosphere, when well-resolved, had the maximal convection speeds ∼0.5–1km/s, total field-aligned currents of a few tenths of MA, thicknesses of a few hundreds km and a potential drop of a few kV across the stream. However, this might represent only a small part of the associated flux transport in the equatorial plasma sheet.Key words. Ionosphere (electric fiels and currents). Magnetospheric physics (aurroal phenomena; energetic particles, precipitating)
3
Pereira, Stephen P., Theresa B. Cassell, Jeffrey L. Engelman, Gordon E. Sladen, Gerard M. Murphy, and R. Hermon Dowling. "Plasma Arachidonic Acid-Rich Phospholipids in Crohn's Disease: Response to Treatment." Clinical Science 91, no. 4 (October 1, 1996): 509–12. http://dx.doi.org/10.1042/cs0910509.
Анотація:
1. Increased concentrations of plasma polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease. However, it is not known whether there are corresponding changes in circulating phospholipids - the major source of fatty acids in the plasma. 2. Fasting plasma samples were obtained from 17 control subjects and 13 patients with active Crohn's disease [Simple Index of Crohn's Disease Activity (SICDA) >6] before, and 2 and 8 weeks after, treatment with either a peptide diet or oral prednisolone. 3. Before treatment, the Crohn's disease patients had mildly active disease (SICDA 9.9 ± 0.8, erythrocyte sedimentation rate 26.4 ± 6.5 mm/h, serum C-reactive protein 2.8 ± 0.4 mg/l). The proportions of the polyunsaturated phosphatidylcholine species, 16:0–20:4 (10.0 ± 0.7%) and 16:0–22:6 (7.1 ± 0.8%), were both significantly higher than those in healthy controls (7.6 ± 0.5%, P < 0.01 and 5.3 ± 0.5%, P < 0.05 respectively). 4. After 2 weeks treatment, the SICDA in the Crohn's disease patients decreased to 3.2 ± 0.6 (P < 0.0001 compared with the pretreatment value), and there were corresponding falls in the erythrocyte sedimentation rate (to 12.6 ± 2.7 mm/h, P < 0.05) and C-reactive protein concentration (to 1.7 ± 0.3 mg/l, P < 0.05)—these improvements being maintained at 8 weeks. There was also a fall to normal values in 16:0–20:4 (to 7.7 ± 0.6%, P < 0.01 compared with the pretreatment value) and in 16:0–22:6 (to 5.7 ± 0.5%, P not significant), by week 8. 5. The proportions of polyunsaturated phosphatidylcholine molecular species were increased in the plasma of patients with active Crohn's disease, but fell to normal levels during disease remission. These observations are consistent with the theory that, in active Crohn's disease, the mucosal phospholipids containing polyunsaturated fatty acids are increased, contribute to eicosanoid synthesis and ‘spill’ into the plasma.
4
Gouw, Samantha C., H. Marijke van den Berg, Johannes Oldenburg, Jan Astermark, Philip G. de Groot, Maurizio Margaglione, Arthur R. Thompson, et al. "F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis." Blood 119, no. 12 (March 22, 2012): 2922–34. http://dx.doi.org/10.1182/blood-2011-09-379453.
Анотація:
Abstract This systematic review was designed to provide more precise effect estimates of inhibitor development for the various types of F8 gene mutations in patients with severe hemophilia A. The primary outcome was inhibitor development and the secondary outcome was high-titer-inhibitor development. A systematic literature search was performed to include cohort studies published in peer-reviewed journals with data on inhibitor incidences in the various F8 gene mutation types and a mutation detection rate of at least 80%. Pooled odds ratios (ORs) of inhibitor development for different types of F8 gene mutations were calculated with intron 22 inversion as the reference. Data were included from 30 studies on 5383 patients, including 1029 inhibitor patients. The inhibitor risk in large deletions and nonsense mutations was higher than in intron 22 inversions (pooled OR = 3.6, 95% confidence interval [95% CI], 2.3-5.7 and OR = 1.4, 95% CI, 1.1-1.8, respectively), the risk in intron 1 inversions and splice-site mutations was equal (pooled OR = 0.9; 95% CI, 0.6-1.5 and OR = 1.0; 95% CI, 0.6-1.5), and the risk in small deletions/insertions and missense mutations was lower (pooled OR = 0.5; 95% CI, 0.4-0.6 and OR = 0.3; 95% CI, 0.2-0.4, respectively). The relative risks for developing high titer inhibitors were similar.
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Brown, Hannah, Nicholas Spies, Mark Zaydman, and Christopher Farnsworth. "Hemoglobin A1c control is an independent predictor of circulating troponin concentrations using machine learning." American Journal of Clinical Pathology 160, Supplement_1 (November 1, 2023): S141—S142. http://dx.doi.org/10.1093/ajcp/aqad150.305.
Анотація:
Abstract Diabetes mellitus (DM) is associated with multiple comorbidities that may precipitate cardiac damage and elevated cardiac troponin (cTn) concentrations including renal failure, hyperlipidemia (HLD), hypertension (HTN), coronary artery disease (CAD), and congestive heart failure (CHF). Diabetics >70 years old have a higher likelihood of adverse outcomes including major cardiovascular events and cardiac mortality. However, the risk to younger diabetic patients and the precipitating factor(s) that facilitate cardiac injury in those with DM are unknown. The objective of this study was to investigate factors predictive of cTn concentrations in young, relatively healthy diabetic patients. We collected 1,533 remnant plasma samples from outpatients between 06/22-09/22 with physician ordered hemoglobin A1c testing. cTn was measured using the Abbott ARCHITECT High Sensitivity Troponin-I assay (limit of detection = 1.7 ng/L, imprecision = 4.76% at 50 ng/L). Demographic information (sex, race, BMI) and pertinent medical history (diabetes, HTN, HLD, CAD, CHF) were collected from the electronic medical record, along with estimated glomerular filtration rate (eGFR) and hemoglobin A1c. Exclusion criteria included: patients with missing laboratory data, those undergoing cancer treatment, or a history of myocardial infarction/cardiomyopathy/ cardiac surgery. Troponin results were classified as normal- or high-risk using a cut-off of 10 ng/L for females and 12 ng/L for males, thresholds previously shown to correlate with incidence of cardiovascular disease risk within 15 years. Univariate statistics were calculated using bootstrap resampling. An XGBoost model was trained to predict high-risk troponinemia, and summary statistics were calculated on a held-out test set. Of the 1,135 patients that met inclusion criteria, 621 (54.7%) were female. The median age was 60 years (IQR: 49-69 years) and the median A1c was 6.2% (IQR: 5.8-7.0%). A total of 746 patients (65.7%) had a prior diabetes diagnosis, with 156 patients (13.7%) having prediabetes, 42 patients (3.7%) having Type 1, and 548 patients (48.3%) having Type 2. Median troponin concentration for patients with an A1c <5.7% was 1.6 ng/L (IQR: 0.8-3.4), 5.7-6.4% was 2.2 ng/L (IQR:1.3-4.8), and ≥6.5% was 2.9 ng/L (IQR: 1.6-6.7). Univariate analysis demonstrated significant differences in troponinemia by age (CI of difference: 4.4-8.9 years), A1c (0.2-0.7%), and eGFR (28-38mL/min/1.73m2). The machine learning model demonstrated strong predictive capacity (sensitivity: 0.74, specificity: 0.86, PPV: 0.5, NPV: 0.92, area under ROC curve: 0.91). The features with the greatest impact on area under the ROC curve when removed were eGFR, Age, A1c, and CHF, suggesting a combination of clinical and laboratory variables can be used to predict circulating troponin concentrations in outpatients. Results of both univariate and multivariate analyses suggest that A1c control is an independent contributor to cTn concentrations. Ultimately, this study provides evidence that glucose control may be associated with cardiac damage and future cardiovascular events, warranting longitudinal outcome studies.
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Liu, Xiang Chun, Feng Gao, Ming Zhao, and Chang Sheng Tian. "Low-Temperature Sintering and Dielectric Properties of (Zn1-xMgx)TiO3." Materials Science Forum 546-549 (May 2007): 2215–18. http://dx.doi.org/10.4028/www.scientific.net/msf.546-549.2215.
Анотація:
The dielectric ceramics comprised of (Zn1-xMgx)TiO3 (x=0.1~0.5, abbreviated to ZMT) were developed by conventional mixed-oxide method combined with a semi-chemical processing. V2O5 was used as sintering aids to lower the sintering temperature of ceramics. The results showed that the hexagonal phase stability region extended from 900 to 1150°C as the amount of magnesium increased. The densification temperature of ZMT ceramics could be reduced from 1200 to 875°C by V2O5 additions and using semi-chemical processing, the relative density of ZMT ceramics with 1.00wt% V2O5 addition reach 95% at 875°C. The dielectric properties of ZMT were measured at different frequencies and the results showed that there existed a decreasing tendency of the loss tangents (tg δ) with increasing measuring frequency. It is concluded that εr=22 and tg δ= 5.7×10-4 can be obtained for ZMT ceramics at sintering temperature 875°C.
7
Soyal, M., M. Kaya, and N. M. Çelik. "Examining the impact of musculus palmaris longus on serve speed and on certain motoric properties in tennis players." Pedagogics, psychology, medical-biological problems of physical training and sports 23, no. 4 (August 28, 2019): 202–8. http://dx.doi.org/10.15561/18189172.2019.0407.
Анотація:
Purpose: The aim of this study is to examine the impacts of existence or absence of musculus palmaris longus (MPL) on serve speed and certain motoric properties in the tennis players. Material: In the study, 25 male volunteers participated, who are playing tennis at university level and in whom the existence of musculus palmaris longus was checked. The ages of volunteers, who participate in tennis activities under licenses, vary between 18 and 25 and they have no disability or illness in the upper extremity. The experimental group (n=7) is comprised of individuals, who do not have musculus palmaris longus, while the control group (n=18) is comprised of individuals having musculus palmaris longus. Results: The age averages of the groups participating in the study was 21, 89±2, 246 years old for the group with musculus palmaris longus, while it was 22, 00±2, 517 years old for the participants without the musculus palmaris longus; as per their average height, it was 174, 94±5, 713 cm for the group with the musculus palmaris longus, while it was 174, 71±3, 546 cm for the participants without the musculus palmaris longus; the body weight average was 70, 83±5, 79 kg for the participants with musculus palmaris longus, while it was 72, 14±4, 059 kg for the participants without the musculus palmaris longus; sports-age average was 13, 00±1, 645 years for the ones with musculus palmaris longus, while it was 12, 29±1, 380 years for the participants without musculus palmaris longus. It was determined that there was statistically significant difference for the serve speed (p<0, 001) and the hand flexion strength (p<0, 05) parameters of the participants; however, there was statistically no significant difference (p>0, 05) in other parameters. Conclusions: As the conclusion, existence of musculus palmaris longus in tennis players positively influences the hand wrist flexion strength, however, it negatively influences the serve speed.
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DESAI, MONIL A., KAMLESH A. SONI, RAMAKRISHNA NANNAPANENI, M. WES SCHILLING, and JUAN L. SILVA. "Reduction of Listeria monocytogenes Biofilms on Stainless Steel and Polystyrene Surfaces by Essential Oils†." Journal of Food Protection 75, no. 7 (July 1, 2012): 1332–37. http://dx.doi.org/10.4315/0362-028x.jfp-11-517.
Анотація:
Plant-derived essential oils were tested for their ability to eliminate biofilms of Listeria monocytogenes on polystyrene and stainless steel surfaces. Various concentrations of essential oils were tested with different contact times on biofilms of various ages. Preliminarily screening of nine essential oils and related phenolic compounds in a disk diffusion assay revealed that thyme oil, oregano oil, and carvacrol had the highest antimicrobial activity. Further screening of these three compounds against 21 L. monocytogenes strains representing all 13 serotypes indicated some strain-specific variations in antimicrobial activity. For 1-day-old biofilms of mixed L. monocytogenes strains produced at 22°C on polystyrene microtiter plates, only 0.1% concentrations of thyme oil, oregano oil, and carvacrol were needed to eliminate 7 log CFU per well. On the stainless steel coupons, a 0.5% concentration of these compounds was adequate to completely eliminate 4-day-old biofilms at 7 log CFU per coupon. Our findings indicate that these compounds are potential candidates for elimination of L. monocytogenes biofilms on stainless steel and polystyrene surfaces.
9
Harrison, S. M., and D. M. Bers. "Influence of temperature on the calcium sensitivity of the myofilaments of skinned ventricular muscle from the rabbit." Journal of General Physiology 93, no. 3 (March 1, 1989): 411–28. http://dx.doi.org/10.1085/jgp.93.3.411.
Анотація:
The steady-state myofilament Ca sensitivity was determined in skinned cardiac trabeculae from the rabbit right ventricle (diameter, 0.13-0.34 mm) at 36, 29, 22, 15, 8, and 1 degree C. Muscles were stimulated to 0.5 Hz and stretched to a length at which maximum twitch tension was generated. The preparation was then skinned with 1% vol/vol Triton X-100 in a relaxing medium (10 mM EGTA, pCa 9.0). Each preparation was exposed to a series of Ca-containing solutions (pCa 6.3-4.0) at two of the six temperatures studied (temperature was regulated to +/- 0.1 degree C). The pCa values (mean +/- SD, n = 6) corresponding to half maximal tension at 36, 29, 22, 15, 8, and 1 degree C were 5.47 +/- 0.07, 5.49 +/- 0.07, 5.34 +/- 0.05, 5.26 +/- 0.09, 4.93 +/- 0.06, and 4.73 +/- 0.04, respectively. Mean (+/- SD) maximum tension (Cmax) developed by the preparation as a percentage of that at 22 degrees C was 118 +/- 10, 108 +/- 5, 74 +/- 6, 57 +/- 7, and 29 +/- 5% at 36, 29, 15, 8, and 1 degree C, respectively. As cooling led to a shift of Ca sensitivity towards higher [Ca2+] and a reduction of Cmax, the Ca sensitivity curves over this range of temperatures do not cross over as has been described for canine Purkinje fibers (Fabiato 1985). Since tension is decreased by cooling at all levels of [Ca2+] it is unlikely that changes in myofilament Ca sensitivity play a role in the large hypothermic inotropy seen in rabbit ventricular muscle. The increase in sensitivity of the myofilaments to Ca on warming from 1 to 29 degrees C might be related to the increase in force seen on rewarming from a rapid cooling contracture in intact rabbit ventricular muscle.
10
Dorn, G. W., J. Robbins, N. Ball, and R. A. Walsh. "Myosin heavy chain regulation and myocyte contractile depression after LV hypertrophy in aortic-banded mice." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 1 (July 1, 1994): H400—H405. http://dx.doi.org/10.1152/ajpheart.1994.267.1.h400.
Анотація:
Using an adult mouse aortic-banded model of pressure-overload hypertrophy and isolated cardiomyocyte mechanics studies, we examined the hypothesis that contractile depression is due to altered cardiac contractile proteins rather than changes in left ventricular (LV) geometry, loading, or the extracellular matrix. FVB mice were banded at the transverse aortic arch or sham operated and studied after 7 days. In nine animals the gradient across the aortic band averaged 47 +/- 4 mmHg. Compared with sham-operated controls, banded animals had increased LV weight-to-body weight ratio (2.8 +/- 0.1 and 3.5 +/- 0.1, respectively; P = 0.035). Left ventricles from additional age-matched groups of mice that underwent identical surgical procedures were examined for altered transcriptional control of myosin heavy chains (MHCs). beta-MHC protein content increased (15 +/- 2%) vs. shams (3.8 +/- 2%; P = 0.004). Dot blots of LV RNA showed a corresponding increase in beta-MHC transcripts in banded animals (15.8 +/- 2%) vs. controls (5.7 +/- 2%; P = 0.012). Contractile performance was assessed using enzymatically disaggregated isolated LV myocytes paced at 0.5 Hz. There was no difference in percentage myocyte shortening between banded (8.6 +/- 0.5%) and control (9.1 +/- 0.5%) animals. However, maximal velocity of contraction was depressed after aortic banding (129 +/- 11 vs. 233 +/- 28 microns/s; P = 0.007), as was velocity of relaxation (105 +/- 11 vs. 188 +/- 22 microns/s; P = 0.007). These results suggest that depressed myocyte contractility after induction of pressure-overload hypertrophy in aortic-banded mice may be, in part, a consequence of transcriptional upregulation of the beta-MHC.
Книги з теми "547.055 22":
1
SPY×FAMILY 02. Buenos Aires, Argentina: Ivrea, 2022.
Частини книг з теми "547.055 22":
1
Escate Vázquez, Juan, Esther Jesús Vilca Perales, Ericka Janet Villamares Hernández, Uldarico Canchari Vásquez, Carmen Navarro de Bernaola, and Juan Teodoro Bernaola Ramos. "Capítulo 8: Planes de incentivos y el desempeño laboral de los obreros agroexportadores de ICA en Perú." In Gestión del conocimiento. Perspectiva multidisciplinaria (libro 60), 165–92. Fondo Editorial de la Universidad Nacional Experimental Sur del Lago, Jesús María Semprum (UNESUR), 2023. http://dx.doi.org/10.59899/ges-cono-60-c8.
Анотація:
El objetivo principal de la investigación general fue demostrar que los Planes de Incentivos se relacionan en el Desempeño Laboral de los obreros de la planta procesadora Peak Quality S.A., Ica, 2020. La metodología aplicada en dicho estudio fue una investigación tipo básica de corte transversal; nivel correlacional, que permitió detallar y encontrar la relación causa – efecto; diseño no experimental, investigación ex post – facto, que relacionó las variables; la población estuvo comprendido por 148 trabajadores y la muestra se constituye de 107 colaboradores al 95% de confiabilidad y 5% de margen de error; la técnica que se utilizó fue encuesta y análisis documental con su respetivo instrumento cuestionario y revisión de documentos para obtener información en forma escrita, a través de 22 preguntas para ambas variables. El resultado del sig asintótica = ,000 < ,05; el coeficiente de correlación de Pearson donde su valor r= .526 una correlación positiva moderada entre las dos variables y con valor sig =,000 < ,050, que se confirma con el coeficiente de contingencia que verifica la intensidad de la relación entre las variables cuyo valor fue de ,541 y p value= ,000< ,05. Por lo que se concluye los planes de incentivos se relacionan positivamente con el desempeño laboral de los obreros de la planta procesadora Peak Quality S.A., Ica.
2
Conceição, Andrezza Fernanda Oliveira, Rodrigo Rodrigues de Souza, and Luiz Carlos Victorino Souza Junior. "A realização profissional e a exaustão emocional de mulheres no retorno ao trabalho após a licença maternidade." In CIÊNCIAS DA SAÚDE E SUAS DESCOBERTAS CIENTÍFICAS. Seven Editora, 2023. http://dx.doi.org/10.56238/ciesaudesv1-053.
Анотація:
Este estudo teve o objetivo de avaliar a percepção de mulheres sobre a exaustão emocional e a realização profissional vivenciadas antes e depois da licença maternidade. A amostra da pesquisa foi composta por 209 mães. A idade variou de 22 à 54 anos, com média de 34,43 anos (DP=5,12). Foram utilizados como instrumentos de pesquisa duas subescalas de um instrumento de diagnóstico de Burnout, sendo uma de exaustão emocional (alpha de cronbach 0,94) e outra de realização profissional (alpha de cronbach 0,88). Um questionário de levantamento de dados sociodemográficos também foi aplicado à amostra. A coleta de dados ocorreu via Google Forms, que foi divulgado em grupos de mães em redes sociais. Para realização das análises de percepção do antes e depois foi utilizado o teste de t para amostras dependentes. Os resultados mostraram que existe uma diferença significativa entre as médias de exaustão emocional antes (2,63) e depois (3,49) e para realização profissional antes (3,82) e depois (3,40). As análises de variâncias das variáveis sociodemográficas (idade, escolaridade, profissão, tempo de profissão, jornada de trabalho, tempo de retorno ao trabalho após a licença a maternidade e período de licença a maternidade), não apresentaram diferenças significativas. Análises de correlações também foram rodadas. As correlações significativas podem ser consideradas, sobretudo, desprezíveis, pois não superaram o valor de 0,17. Conclui-se que, na amostra estudada, a retorno às atividades profissionais, juntamente com o papel de mãe, reduz a percepção de realização profissional e aumenta a exaustão emocional das mães.
Тези доповідей конференцій з теми "547.055 22":
1
Cabioglu, N., A. Bozdogan, D. Eren-Boler, H. Kara, H. Karayagiz, and C. Uras. "Abstract P6-05-22: Young-onset breast cancer exhibits a more aggressive tumor biology." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p6-05-22.
2
JASINSKI,, MARCIN, KRZYSZTOF SZCZUROWSKI, ADAM WISNIEWSKI, PRZEMYSLAW BADU BADUROWICZ, MAREK WOLINSKI, and TADEUSZ BARTKOWIAK. "FLAMMABILITY ANALYSIS OF GAS CYLINDERS UNDER FIRING IN DIFFERENT ENVIRONMENTAL CONDITIONS." In 32ND INTERNATIONAL SYMPOSIUM ON BALLISTICS. Destech Publications, Inc., 2022. http://dx.doi.org/10.12783/ballistics22/36063.
Анотація:
This paper presents the results of testing such materials with bullets: 7.62×54R LPS FMJ, 7.62×39 BZ, 7.62×54R B-32 API and 7.62x51T. For the study, 11 kg propanebutane gas cylinder was used with different gas content: 0.5 - 5 kg at ambient temperature 22°C. One to five shots were taken at each cylinder, and the heat flux and overpressure wave were estimated under various assumed storage and transport conditions. The impact of the bullets was recorded with a high-speed camera and thermal camera. This paper presents the temperature ranges, burning area spread areas and histograms due to the impact of various bullets on flammable gas cylinders. The excitation conditions for flammable gas cylinders to burn were determined.
3
Berg, PE, S. Ghimbovschi, WE Grizzle, and TH Nguyen. "Abstract P2-05-22: Preferential Activation of BP1 and c-Myc in Breast Cancer of African American Women Compared with Caucasian American Women." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p2-05-22.
4
Chen, Qianglong, Feng-Lin Li, Guohai Xu, Ming Yan, Ji Zhang, and Yin Zhang. "DictBERT: Dictionary Description Knowledge Enhanced Language Model Pre-training via Contrastive Learning." In Thirty-First International Joint Conference on Artificial Intelligence {IJCAI-22}. California: International Joint Conferences on Artificial Intelligence Organization, 2022. http://dx.doi.org/10.24963/ijcai.2022/567.
Анотація:
Although pre-trained language models (PLMs) have achieved state-of-the-art performance on various natural language processing (NLP) tasks, they are shown to be lacking in knowledge when dealing with knowledge driven tasks. Despite the many efforts made for injecting knowledge into PLMs, this problem remains open. To address the challenge, we propose DictBERT, a novel approach that enhances PLMs with dictionary knowledge which is easier to acquire than knowledge graph (KG). During pre-training, we present two novel pre-training tasks to inject dictionary knowledge into PLMs via contrastive learning: dictionary entry prediction and entry description discrimination. In fine-tuning, we use the pre-trained DictBERT as a plugin knowledge base (KB) to retrieve implicit knowledge for identified entries in an input sequence, and infuse the retrieved knowledge into the input to enhance its representation via a novel extra-hop attention mechanism. We evaluate our approach on a variety of knowledge driven and language understanding tasks, including NER, relation extraction, CommonsenseQA, OpenBookQA and GLUE. Experimental results demonstrate that our model can significantly improve typical PLMs: it gains a substantial improvement of 0.5%, 2.9%, 9.0%, 7.1% and 3.3% on BERT-large respectively, and is also effective on RoBERTa-large.
5
Ngan, E., JJ Northey, J. Ursini-Siegel, and PM Siegel. "Abstract P1-05-22: Breast cancer cells that undergo an Epithelial-to-Mesenchymal transition co-opt LPP, a regulator of mesenchymal cell migration and invasion." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p1-05-22.
6
Suzart, Gabriel Souza, Ingrid Sanchez, Daniel Guimarães, Pedro Augusto Assis Lopes, and Pedro Antonio Pereira de Jesus. "Association between Human Development Index and Delay on Arrival to Stroke Unit." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.668.
Анотація:
Background: Stroke outcomes depend somehow on the time taken from the symptoms onset until arrival to the specialized service. However, as it lacks literature exploring the impact of socio-demographics factors on this time, we investigated the association between Human Development Index and delay on arrival to specialized service. Design and setting: Cross-sectional study from a prospective cohort (PMID=33719516) at Hospital Geral Roberto Santos. Methods: From a total of 454 stroke patients, 156 were included in this study because they had registered address, time of admission and of symptoms onset. Patients had HDI defined by their address and were grouped into HDI categories. Results: In our sample, 57 (36,5%) individuals had medium HDI, 70 (44,9%) high HDI and 29 (18,6%) very high HDI. Very high HDI patients’ delay (2:01; 1:22-2:57) was lower than high HDI (3:05; 2:05-5:26) and medium HDI (2:25;1:45-4:04) patients. There was statistical significance comparing these groups (X²=11,41;p<0,05), but a post-hoc test revealed statistical difference just between the very high HDI and high HDI groups (p<0.05). Conclusions: We expected to find a direct relation between delay on arrival to the stroke service and HDI categories. However, this was not observed. *Authors contributed equally.
7
Blanton, John C., and Daniel P. Smith. "Gas Turbine Combustion of a Minimally Cleaned, Coal-Derived Low-BTU Gas." In ASME 1985 International Gas Turbine Conference and Exhibit. American Society of Mechanical Engineers, 1985. http://dx.doi.org/10.1115/85-gt-160.
Анотація:
As part of the joint GE/DoE Water-Cooled Components Test Program,1 a series of tests were performed involving the combustion of a minimally cleaned low-Btu coal gas in a pressurized gas turbine simulator. The fuel gas was produced in a 1-ton/hr advanced fixed-bed gasifier using Illinois #6 coal, and filtered of particulate in a full-pressure, full-temperature cyclone separator. The resulting product had a gross heating value of approximately 5000 kJ/kg at a temperature of 540 °C and a pressure of 22 bar. Numerous contaminants also remained in the fuel gas, including approximately 100 ppmw particulate matter (coal dust of 3 μm average size), 2000–4000 ppmv ammonia, 2000–2500 ppmv H2S, and 0.5–1.0% vaporized tars, oils, phenols, and other condensible hydrocarbons. The fuel gas was burned with air at 6–7 bar pressure and 400 °C temperature in a gas turbine combustion system at overall fuel-air ratios up to 0.25 (overall equivalence ratio 0.36). Gaseous emissions were sampled in the exhaust stream and measurements made for O2, CO2, CO, unburned hydrocarbons, NOx, and SOx. The CO and unburned hydrocarbon emissions were both below 20 ppmv at full firing conditions, indicating acceptable combustion efficiency. The NOx levels measured were up to 500 ppmv, and were due to the of conversion of fuel-bound nitrogen (ammonia principally). The SOx emissions directly followed the oxidation of fuel-bound sulfur (H2S principally). At part-load conditions, emissions of CO and unburned hydrocarbons were observed to increase, as expected. Stable operation was maintained down to a combustion system temperature rise of approximately 350 °C.
8
Huober, J., P. Weder, E. Boven, C. Oehlschlegel, G. Mac Grogan, B. Thuerlimann, Q. Li, et al. "Abstract OT1-1-05: Pernetta: A randomized phase II trial of pertuzumab + trastuzumab with or without chemotherapy, both followed by T-DM1 at progression, in patients with HER2-positive metastatic breast cancer - SAKK 22/10 / UNICANCER UC-0140/1207." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-ot1-1-05.
9
Ковалева, Е. В., А. Р. Елфимова, А. К. Еремкина, О. К. Викулова, Г. А. Мельниченко, И. И. Дедов та Н. Г. Мокрышева. "КЛИНИЧЕСКИЕ ОСОБЕННОСТИ ТЕЧЕНИЯ ХРОНИЧЕСКОГО ГИПОПАРАТИРЕОЗА ПО ДАННЫМ ВСЕРОССИЙСКОГО РЕГИСТРА". У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-25.
Анотація:
ЦЕЛЬ: изучить особенности клинического течения хронического гипопаратиреоза в российской по-
пуляции.
МАТЕРИАЛЫ И МЕТОДЫ: исследование проведено на основе данных Всероссийского регистра паци-
ентов с хроническим послеоперационным (п/о) и нехирургическим (н/х) гипопаратиреозом, основанного
в 2020 году под эгидой ГНЦ ФГБУ «НМИЦ эндокринологии» Минздрава России (http://gipopt.clin-reg.ru/).
Электронная информационно-аналитическая платформа регистра позволяет в режиме онлайн вводить
информацию по пациентам с данной патологией в различных регионах Российской Федерации (РФ), а также
обладает динамической системой аналитики. Выгрузка базы данных проведена 18.01.2023 г.
РЕЗУЛЬТАТЫ: общее число включенных в исследование пациентов составило 1039 человек (мужчин/
женщин – 131/907, жив/умер – 1036/3) из 68 регионов РФ. Хронический п/о гипопаратиреоз наблюдался
в 87,4% случаев (909/1039), н/х – в 12,6% (130/1039). П/о гипопаратиреоз в 43% случаев (391/909) развил-
ся после хирургического лечения рака щитовидной железы, узлового и диффузного токсического зоба
в 24% (218/909) и 14% (131/909), соответственно, после паратиреоидэктомии в 5% (43/909), в том числе
селективной – в 35% (15/43). В структуре н/х гипопаратиреоза преобладал идиопатический вариант – 65%
(60/92); реже – аутоиммунный (24%, 22/92) и другие наследственные формы (11%, 10/92). Медиана возраста
на момент постановки диагноза н/х гипопаратиреоза была ожидаемо меньше, чем в группе п/о гипопара-
тиреоза – 13 [5; 20] против 47 [36; 57] лет (р<0,0001, U-тест, поправка Бонферрони Р0=0,0036).
Выявлена статистическая тенденция к более низким уровням кальциемии (медиана ионизированного
кальция 0,98 ммоль/л [0,85; 1,08] против 1,04 [0,94; 1,12], р=0,018, U-тест, поправка Бонферрони Р0=0,0036)
и магниемии (0,75 ммоль/л [0,70; 0,80] против 0,71 [0,65; 0,76], р=0,005), более высокому уровню фосфора
крови (1,58 ммоль/л [1,21; 2,09] против 1,48 [1,31; 1,67]) у пациентов с н/х гипопаратиреозом по сравнению
с п/о формой. По уровню суточной кальциурии группы не различались (р>0,05), однако пациенты с п/о ги-
попаратиреозом имели значимо более низкие показатели рСКФ – 75,0 мл/мин/1,73 м2 [60,3; 91,1] против
91,3 [68,7; 112,2] (р<0,0001, U-тест, поправка Бонферрони Р0=0,0036).
В терапии гипопаратиреоза чаще всего, в 75% случаев, использовалась стандартная комбинация в виде
сочетания активных форм витамина D и препаратов кальция. Дозы лекарственных препаратов (альфа-
кальцидола, кальцитриола, карбоната кальция) в группах с п/о и н/х гипопаратиреозом не различались:
1,50 мкг/сут [1,00; 2,00] против 1,25 [1,00; 2,25], 1,0 мкг/сут [0,5; 1,5] против 1,00 [0,50; 1,75] и 1500 мг/сут
[1000; 2000] против 1200 [1000; 2000] соответственно (р>0,05).
ВЫВОДЫ: самой частой причиной гипопаратиреоза в РФ является повреждение или удаление око-
лощитовидных желез в ходе хирургического лечения по поводу различных заболеваний щитовидной
железы, что согласуется с результатами мировых данных. Пациенты с н/х гипопаратиреозом имеют более
раннюю манифестацию заболевания и тенденцию к более выраженным нарушениям минерального об-
мена по сравнению с лицами с п/о патологией. Большинство пациентов получают стандартную терапию
с умеренными суточными дозами препаратов, что соответствует позициям федеральных клинический
рекомендаций по гипопаратиреозу.
Источник финансирования: государственное задание «Всероссийский реестр пациентов
с хроническим гипопаратиреозом как основа оптимизации и внедрения персонализированного под-
хода для улучшения качества оказания медицинской помощи населению Российской Федерации»,
НИОКТРАААА-А20-120011790168-2.