Статті в журналах: "51-78"

1

Rede, Lata Arun. "Business Cycles and Rate of Profit in Indian Manufacturing Industries: 1950-51 to 1977-78." Artha Vijnana: Journal of The Gokhale Institute of Politics and Economics 30, no. 3 (September 1, 1988): 287. http://dx.doi.org/10.21648/arthavij/1988/v30/i3/116375.

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2

Newman, Josh. "Review of Poverty and the Poor Law in Ireland, 1850-1914, by Virginia Crossman." Review of Irish Studies in Europe 4, no. 1 (June 14, 2021): 194–96. http://dx.doi.org/10.32803/rise.v4i1.2691.

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3

Loffroy, R., D. Krausé, B. Guiu, D. Ben Salem, A. Chavent, L. Vadanici, N. Mejean, E. Steinmetz, F. Ricolfi, and J. P. Cercueil. "NR-WS-51 Ischemie chronique, vieillissement cerebral et stenting carotidien. Suivi au long cours : 78 patients." Journal de Radiologie 89, no. 10 (October 2008): 1579–80. http://dx.doi.org/10.1016/s0221-0363(08)76910-5.

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4

Bijlsma, P. B., J. A. Groot та JAJM Taminiau. "78 SOLVENTDRAG-RELATEDDECREASE IN 51 Cr-EDTA/14C-MANNITOL FLUX RATIOʼS IN RAT ILEUM IN VITRO". Journal of Pediatric Gastroenterology and Nutrition 19, № 3 (жовтень 1994): 348. http://dx.doi.org/10.1097/00005176-199410000-00090.

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5

Langienė, Vita, and Violeta Drejerienė. "NEIŠNEŠIOTŲ NAUJAGIMIŲ, GIMUSIŲ VILNIAUS MIESTO KLINIKINĖJE LIGONINĖJE, MAITINIMAS. ŽINDYMO SĖKMĘ NULĖMĘ VEIKSNIAI." Visuomenės sveikata 28, no. 5 (November 29, 2018): 27–31. http://dx.doi.org/10.5200/sm-hs.2018.055.

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Tyrimo tikslas. Išanalizuoti 1 metų duomenis apie Vilniaus miesto klinikinėje ligoninėje (VMKL) gimusių vėlyvų neišnešiotų naujagimių maitinimą, įvertinti gestacinio amžiaus įtaka natūralaus maitinimo dažniui. Metodika. Atlikta retrospektyvinė 2015 m. - 2016 m. VMKL gimusių neišnešiotų naujagimių raidos istorijų analizė. Šių gimusių kūdikių tolesnio maitinimo analizei atlikti ir įvertinti buvo sudaryta ir naudota retrospektyvi motinų apklausos anketa. Rezultatai. Iš 100 tyrime dalyvavusių vėlyvų neišnešiotų naujagimių iš stacionaro išimtinai žindomi išvyko 78 (78 proc.). Vėlyvi neišnešioti naujagimiai statistiškai rečiau išvyko natūraliai maitinami neišnešioti naujagimiai (p&lt;0,05). Didžioji dalis vėlyvų neišnešiotų naujagimių (n=92, 92 proc.) toliau sėkmingai žindyti iki 3 mėn., 88 (88 proc.) iki 6 mėn., 51 (51 proc.) iki 12 mėn., 24 (24 proc.) iki ≥18 mėn. Išnešiotų ir vėlyvų neišnešiotų kūdikių iki 6 -18 mėnesių amžiaus natūralaus maitinimo ir sėkmingo žindymo rezultatai praktiškai vienodi. Išvados. Vėlyvi neišnešioti naujagimiai po gimimo rečiau natūraliai maitinami nei išnešioti naujagimiai (p&lt;0,05). Tačiau ženklaus skirtumo tarp tolimesnio šių naujagimių sėkmingo žindymo dažnio nenustatėme.

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6

Cerna, Marco. "Caracterización botánica del volcán Quilotoa." La Granja 4, no. 1 (August 1, 2006): 79. http://dx.doi.org/10.17163/lgr.n4.2005.16.

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Este trabajo se realizó en la provincia de Cotopaxi, en el volcán Quilotoa, en cuyo interior se encuentra una laguna, en las coordenadas 78°, 54', 06" W y 00°, 51', 21 "S, a 3980 msnm la parte más alta y a 3 540 msnm el nivel del agua. Esta zona corresponde a un páramo herbáceo.

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7

Hanna, Lezley-Anne, Alana Murphy, Maurice Hall, and Rebecca Craig. "Future Pharmacists’ Opinions on the Facilitation of Self-Care with Over-the-Counter Products and Whether This Should Remain a Core Role." Pharmacy 9, no. 3 (July 31, 2021): 132. http://dx.doi.org/10.3390/pharmacy9030132.

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Background: The aim was to investigate pharmacy students’ views on the role of the pharmacist in facilitating self-care with over-the-counter (OTC) medicines, particularly in light of new roles, and establish personal practice. Methods: Final year pharmacy students at Queen’s University Belfast were invited to participate. Data were collected via a pre-piloted questionnaire, distributed at a compulsory class (only non-identifiable data were requested). Descriptive statistics were performed, and non-parametric tests were employed for inferential statistical analysis (responses by gender). Results: The response rate was 87.6% (78/89); 34.6% (27/78) males and 65.4% (51/78) females. Over a third [34.6% (27/78)] reported using OTC medicines about once a month. All appreciated the importance of an evidence-based approach to optimize patient care. Most [(96.2% (75/78)] deemed OTC consultations should remain a fundamental responsibility of pharmacists and 69.2% (54/78) thought OTC consultations have the potential to be as complex as independent pharmacist prescribing. Females felt more confident recommending OTC emergency contraception than males (p = 0.002 for levonorgestrel and p = 0.011 for ulipristal acetate). Many [61.5% (48/78)] considered more medicines should not be deregulated from prescription-only status. Conclusions: Data from this single institution suggests that enabling self-medication is an important part of practice but there were confidence issues around deregulations.

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8

Cortus, E. L., H. W. Gonyou, S. P. Lemay, and E. M. Barber. "Measuring and simulating the urination frequency of grower-finisher pigs." Canadian Journal of Animal Science 85, no. 4 (December 1, 2005): 537–39. http://dx.doi.org/10.4141/a05-045.

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Male and female pigs were observed three times during their finishing phase to determine their urination frequency over the course of a day (0.62 ± 0.11 U pig-1 h-1). A single dromedary model is used to describe the daily variation in urination frequency for male and female pigs between 51 and 78 kg. Key words: Urination, grower-finisher pigs, animal activity

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9

Castro, Cleudson, Vanize Macêdo, and Aluízio Prata. "Comportamento da parasitemia pelo Trypanosoma cruzi em chagásicos crônicos durante 13 anos." Revista da Sociedade Brasileira de Medicina Tropical 32, no. 2 (April 1999): 157–65. http://dx.doi.org/10.1590/s0037-86821999000200007.

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Foi estudada a parasitemia de 202 chagásicos crônicos por um período médio de 13 anos, através de repetidos xenodiagnósticos convencionais. Os pacientes tinham média de idade de 41,4 anos, residiam em área endêmica, sendo 124 do sexo feminino e 78 do sexo masculino. Foi observado que o nível de parasitemia aumentou em 14 indivíduos, diminuiu em 42 e permaneceu inalterado em 146. Porém, no geral, a parasitemia declinou. Os percentuais de chagásicos xenopositivos que foram 37,6%, 48,5%, 51% no primeiro, segundo e terceiro xenodiagnósticos, respectivamente, em 1976/78, passaram a ser 30,2% em 1988/91 (p = 0,00003). Os percentuais de pools positivos que foram 15,2%, 20,9%, 20,8% no primeiro, segundo e terceiro xenodiagnósticos, respectivamente, em 1976/78, passaram a ser 10,4% em 1988/91, (p = 0.00000001). Houve 62 pacientes que tiveram todos os xenodiagnósticos negativos e 23 que apresentaram todos os exames positivos. Os percentuais de chagásicos com alta, média e baixa parasitemias que, em 1976/78, foram, respectivamente, 9,4%; 20,8% e 69,8% passaram a ser, em 1988/91, respectivamente, 4,4%, 12,9% e 82,7%.

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10

Sinaini, La, and Mulyati Azi. "Retracted: Analysis of production affecting factors milkfish (Chanos chanos) in Muna Regency." Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil 2, no. 2 (November 24, 2018): 49. http://dx.doi.org/10.29239/j.akuatikisle.2.2.49-51.

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Following a rigorous, carefully concerns and considered review of the article published in Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil to article entitled “Analysis of production affecting factors milkfish (Chanos chanos) in Muna Regency” Vol 2, No 2, pp. 49-51, November 2018, DOI: https://doi.org/10.29239/j.akuatikisle.2.2.49-51. The article contained redundant material, the editor investigated and found that the paper double published in Buletin Penelitian Sosial Ekonomi Pertanian Fakultas Pertanian Universitas Haluoleo, Vol. 21, No. 2, pp. 75-78, November 2019. DOI: http://dx.doi.org/10.33772/bpsosek.v21i2.7751The document and its content has been removed from Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil and reasonable effort should be made to remove all references to this article

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11

Kotlo, Kumar, Arivarasu N. Anbazhagan, Shubha Priyamvada, Dulari Jayawardena, Anoop Kumar, Yang Chen, Yinglin Xia, et al. "The olfactory G protein-coupled receptor (Olfr-78/OR51E2) modulates the intestinal response to colitis." American Journal of Physiology-Cell Physiology 318, no. 3 (March 1, 2020): C502—C513. http://dx.doi.org/10.1152/ajpcell.00454.2019.

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Olfactory receptor-78 (Olfr-78) is a recently identified G protein-coupled receptor activated by short-chain fatty acids acetate and propionate. A suggested role for this receptor exists in the prostate where it may influence chronic inflammatory response leading to intraepithelial neoplasia. Olfr-78 has also been shown to be expressed in mouse colon. Short-chain fatty acids and their receptors are well known to modulate inflammation in the gut. Considering this possibility, we first explored if colitis regulated Olfr-78 expression in the gut, where we observed a significant reduction in the expression of Olfr-78 transcript in mouse models of dextran sodium sulfate (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. To more directly test this, mice deficient in Olfr-78 were administered with DSS in water for 7 days and were found to have increased expression of IL-1β and inflammatory signs in colon compared with control mice. Next, we explored the expression of its human counterpart olfactory receptor family 51, subfamily E, member 2 (OR51E2) in human intestinal samples and observed that it was in fact also expressed in human colon samples. RNA sequence analysis revealed significant changes in the genes involved in infection, immunity, inflammation, and colorectal cancer between wild-type and Olfr-78 knockout mice. Collectively, our findings show that Olfr-78 is highly expressed in colon and downregulated in DSS- and TNBS-induced colitis, and DSS-treated Olfr-78 null mice had increased colonic expression of cytokine RNA levels, suggesting a potential role for this receptor in intestinal inflammation. Future investigations are needed to understand how Olfr-78/OR51E2 in both mouse and human intestine modulates gastrointestinal pathophysiology.

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12

Issa, H. "Brucellosis in children in south Jordan." Eastern Mediterranean Health Journal 5, no. 5 (October 15, 1990): 895–902. http://dx.doi.org/10.26719/1999.5.5.895.

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Retrospectively we evaluated the records of 68 children with brucellosis. We found 58.2% had consumed unpasteurized milk and dairy products. Nonspecific manifestations included: arthralgia [78%], fever [75%]and sweating [60%]. Localized manifestations included limping [75%]and arthritis [54%]. Leukopenia was found in 51% of children and anaemia in 24%. Brucella species was cultured for blood of 16 [23.5%]patients. Combination therapy containing streptomycin was more effective than gentamicin combinations

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13

Mitra, I., J. R. Nichani, B. Yap, and J. J. Homer. "Effect of central compartment neck dissection on hypocalcaemia incidence after total thyroidectomy for carcinoma." Journal of Laryngology & Otology 125, no. 5 (November 25, 2010): 497–501. http://dx.doi.org/10.1017/s0022215110002471.

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AbstractIntroduction:Central compartment neck dissection is increasingly performed as part of surgical management of differentiated thyroid carcinoma. However, elective central neck dissection remains controversial due to complications and lack of evidence of survival benefit.Objective:To investigate and compare rates of transient and permanent hypocalcaemia following total thyroidectomy alone, compared with total thyroidectomy with central neck dissection, for differentiated thyroid carcinoma.Methods:Retrospective study of 127 consecutive patients referred with differentiated thyroid carcinoma, 2004–2006; 78 patients had undergone total thyroidectomy (group one) and 49 total thyroidectomy with central compartment node dissection (group two). Surgery was performed in various hospitals by both otolaryngologists and endocrine surgeons.Results:In groups one and two, the incidence of transient hypocalcaemia was 18 per cent (14/78) and 51 per cent (25/49) (p < 0.001), and the incidence of permanent hypocalcaemia 1 per cent (one of 77) and 12 per cent (six of 49) (p < 0.01), respectively. Most patients undergoing central neck dissection had evidence of pathological level six lymphadenopathy (29/49).Conclusion:Total thyroidectomy combined with central neck dissection for the treatment of differentiated thyroid carcinoma is more likely to result in transient (51 per cent) and permanent (12 per cent) hypocalcaemia. Elective neck dissection should be performed selectively, with a high expectation of post-operative hypocalcaemia.

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14

Miano, Maurizio, Andrea Todiere, Ilaria Caviglia, Elena Palmisani, Johanna Svahn, Concetta Micalizzi, Paola Terranova, Tiziana Lanza, Carlo Dufour, and Francesca Fioredda. "Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-Related Disorders. Different Bio-Clinical Profile and Similar Response to Treatment: A Single Centre Experience." Blood 126, no. 23 (December 3, 2015): 4618. http://dx.doi.org/10.1182/blood.v126.23.4618.4618.

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Abstract ALPS is an inherited disorder characterized by lymphoproliferation and autoimmunity that mainly involves blood cells. In the last few years, new disorders other than ALPS have been found to cause lymphoproliferative syndromes, and many patients with similar clinical features but not fitting ALPS diagnostic criteria have been described. In this study we evaluate clinical features and response to the treatment of patients with ALPS and ALPS-related Syndromes (ARS) followed in a single Center. ALPS was defined according to the revised diagnostic criteria (first international Workshop, 2009). ARS was defined as the presence of cytopenia and/or lymphoproliferation and at least one absolute or primary additional criterion for ALPS. Medical records of patients followed in our Center between 2001 and 2014 for these conditions were evaluated. Sixty-five patients (35 males), with median age at diagnosis of 10 years (range 0-39) with ALPS (32) (definitive: 21, probable: 11), or ARS (33) entered this study. A positive history of lymphoproliferation was present in 8/32 (25%) and in 3/33 (9%) of ALPS and ARS subjects, respectively. Lymphoproliferation was present in 51/65 (78%) patients and consisted of isolated lymphoadenopathy (10/51, 19%), isolated splenomegaly (26/51, 51%), or both conditions (15/51, 29%). It was present in 32/32 (100%) and in 19/33 (57%) of patients with ALPS or ARS, respectively. In particular, lymphoadenopathy was present in 17/32 (53%) and in 8/33 (24%) of ALPS and ARS patients, respectively (p 0.04). Splenomegaly was found in 27/32 (84%) and in 14/33 (43%) of ALPS and ARS subjects respectively (p < 0.01) Cytopenia was present in 51/65 (78%) of patients and involved one (28/51, 55%) or more cell lineage in (23/51, 45%). Trilinear cytopenia was present in 7 ALPS patients and in no subjects with ARS (p<0.01). Isolated thrombocytopenia was the most frequent occurring in 4/32 (12%) and in 12/33 (36%) ALPS and ARS, respectively (p 0.03). No statistical difference was found on the incidence of other type of cytopenia between the 2 groups. The median percentage of Double Negative T-cells/total lymphocytes was 2.6 (range 1.5-14.8) and 1.8 (range 0.6-9.2) in ALPS and ARS patients, respectively (p<0.01). Autoantibodies were present in 17/32 (53%) and in 20/33 (58%) ALPS and ARS patients, respectively, being ANA the most frequently found marker (9/17 ALPS, 8/19 ARS). Autoimmune symptoms other than cytopenia were present in 13/32 (41%) and in 5/33 (15%) patients with ALPS and ARS, respectively (p<0.02). The most common symptom was arthritis that was present in 8 patients (4 ALPS, 4 ARS). The other issues consisted of tyroiditis, hepatitis, nephrosis syndrome, eczema, cholangitis, celiac disease, colitis, and psoriasis. Fifty-one/65 (78%) patients required treatment and 10/51 (20%) responded to steroids/Immunoglobulin given as first line therapy. The remaining 41 (80%) patients required further lines of treatment. Thirty-four/41 (83%) received MMF for a median of 314 days with a partial/complete response in 17/25 (68%) evaluable patients, and in particular, in 11/14 (79%) and 6/11 (54%) of ALPS and ARS patients, respectively. Mild side-effects (vomit, gastrointestinal issues, fever, headache) were reported in 5 (15%) patients. Sirolimus was given for a median of 395 days to 18/41 (44%) patients, including 11 patients who had previously failed MMF treatment, and led to a partial/complete response in 12/16 (75%) patients and, in particular, in 5/7 (71%) and 7/9 (78%) of ALPS and ARS patients, respectively. Vomit was reported as side effect in one (6%) patient. Median duration of follow-up was 3.3 years (range 0-12.6) This study confirms the existence of a group of patients who do not fulfil ALPS diagnostic criteria and display a more attenuated bio-clinical phenotype. The presence of lymphoproliferation and elevated DNT is the main feature differentiating ALPS from ARS patients. Trilinear cytopenia is a typical feature of ALPS patients and isolated thrombocytopenia is more frequent in ARS patients. The presence of autoimmune symptoms other than cytopenia is more frequent in ALPS patients. MMF and Sirolimus, which are reported as safe and effective in ALPS patients, may represent a valid option for the treatment of ALPS-related disorders as well. Further studies are needed to identify the immunological defects underlying ARS patients which may help for a better classification of these disorders. Disclosures Dufour: Pfizer: Consultancy.

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15

Malagola, Michele, Raffaella Greco, Stella Santarone, Anna Paola Iori, Luisa Quatrocchi, Walter Barberi, Bruzzese Antonella, et al. "CMV MANAGEMENT WITH SPECIFIC IMMUNOGLOBULINS: A MULTICENTRIC RETROSPECTIVE ANALYSIS ON 92 ALLOTRANSPLANTED PATIENTS." Mediterranean Journal of Hematology and Infectious Diseases 11, no. 1 (August 29, 2019): e2019048. http://dx.doi.org/10.4084/mjhid.2019.048.

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CMV represents one of the most serious life-threatening complications of allogeneic stem cell transplantaion (allo-SCT). Pre-emptive treatment is highly effective, but toxicity and repetitive reactivation of CMV represent a major challenge in the clinical practice. The use of anti-CMV specific immunoglobulins (Megalotect) is controversial. We retrospectively collected data on 92 patients submitted to allo-SCT for hematological malignancies, in whom Megalotect was used either for prophylaxis (n=14) or with pre-emptive therapy (n=78). All the patients were considered at high-risk of developing CMV reactivation and CMV disease. The treatment was well tolerated, with no reported infusion reactions, nor other adverse events. None of the 14 cases treated with Megalotect as prophylaxis developed CMV reactivation. 51/78 (65%) patients who received Megalotect during pre-emptive treatment achieved complete clearance of CMV viremia, and 14/51 patients (29%) developed a breakthroug CMV infection. 7/78 patients (9%) developed CMV disease. The projected 1-year OS, 1-year TRM and 1-year RR is 74%, 15% and 19%, respectively. No differences were observed in terms of OS, TRM and RR by comparing patients who achieved a complete response after treatment versus those who did not.. These retrospective data suggest that Megalotect is safe and well tolerated. When used as prophylaxis, no CMV reactivation was recorded. We have no conclusive data regarding its efficacy in reducing the cumulative dose of anti-CMV specific drugs in the pre-emptive setting. Further prospective trials are warrented to identify the best setting of patients who can benefit from Megalotect alone or in addition to anti-CMV specific drugs.

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16

Cappilli, Simone, Giulia Giovanardi, Alessandro Di Stefani, Caterina Longo, Francesca Perino, Andrea Chiricozzi, and Ketty Peris. "Real-Time Confocal Imaging for Hidradenitis Suppurativa: Description of Morphological Aspects and Focus on the Role of Follicular Ostia." Dermatology 237, no. 5 (2021): 705–11. http://dx.doi.org/10.1159/000513918.

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Background: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease involving the follicular unit. Growing evidence suggests a crucial role of hyperkeratosis, infundibular plugging and perifolliculitis in its pathogenesis. Objectives: To characterize the microscopic morphology of open comedos using in vivo reflectance confocal microscopy (RCM) and define alterations occurring in HS normal-appearing perilesional skin compared to healthy skin of a control group, discussing therefore microscopic differences. Materials and Methods: Twenty patients (11 males, 9 females; aged 19–51 years) affected by HS were recruited. RCM was performed on open comedos of axillary/inguinal regions and on normal-appearing skin areas distant at least 1.5 cm from HS lesions. Ten healthy individuals (6 males, 4 females) were included as control group. Results: RCM aspects of 78 open comedos were explored, observing circular/ovoidal structures disclosing a hyperrefractive amorphous material (72/78, 92.3%) within the infundibular cavity surrounded with a bright (51/78, 65.4%) and regular (52/78, 66.2%) border. Follicular ostia of HS perilesional skin (n = 541) compared to follicular ostia of a control group (n = 321) were characterized by a larger infundibular diameter (183.4 vs. 85.8 µm) and diverged in terms of material collected inside infundibula (44.5 vs. 21%) and keratinization of the border (47.6 vs. 25.5%). Conclusion: In vivo characterization of open comedos and the recognition of microscopic subclinical alterations of HS normal-appearing skin, compared to healthy skin, could add further insights into the definition of biological events leading to HS manifestations, including the dysregulated process of keratinization.

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17

Sun, Wan-jun, Jia-jia Zhang, Na An, Men Shen, Zhong-xia Huang, and Xin Li. "Clinical analysis of 40 multiple myeloma patients with extramedullary plasmacytoma of the head." Journal of International Medical Research 44, no. 6 (November 11, 2016): 1462–73. http://dx.doi.org/10.1177/0300060516664820.

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Objectives To investigate the clinical characteristics, survival and prognosis of patients with multiple myeloma (MM) and head extramedullary plasmacytoma (EMP). Methods Forty MM patients were enrolled in the study (18 men, 22 women; median age, 55 years). Results Median overall survival (OS) and progression-free survival (PFS) were 24 (5–78) months and 17 (2–36) months, respectively. The 2-, 3- and 5-year OS rates were 51%, 20% and 7%, respectively. The 2-year PFS was 15%. Median OS and PFS in patients administered velcade were 26 (18–50) and 22.5 (5–78) months, compared with 20 (10–30) and 13.5 (2–36) months in patients without velcade, respectively. Median OS was 23.5 (5–50) months in patients with EMP at MM diagnosis ( n = 25) and 36 (22–78) months in patients with head EMP diagnosed during the disease course ( n = 15). Sixteen MM patients had EMP invasion of the head only and 24 had invasion at multiple sites. Median OS was 25 (22–78) months in patients with EMP of the head only and 22 (5–78) months in patients with EMP invasion at multiple sites. Conclusion MM patients with head EMP show a more aggressive disease course and shorter OS and PFS. The prognosis of these patients is poor, especially in patients with head EMP at MM diagnosis, though combined chemotherapy and radiotherapy may prolong survival.

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Hahn, Theresa, Philip L. McCarthy, Anna Hassebroek, John P. Klein, J. Douglas Rizzo, Susan Parsons, Steven Joffe, and Navneet S. Majhail. "Significant Improvement In Day 100 and 1-Year Overall Survival In Patients Who Underwent Myeloablative Allogeneic Hematopoietic Cell Transplant In the US or Canada Between 1994 and 2005." Blood 116, no. 21 (November 19, 2010): 3509. http://dx.doi.org/10.1182/blood.v116.21.3509.3509.

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Abstract Abstract 3509 Allogeneic hematopoietic cell transplantation (alloHCT) has become standard therapy for hematologic disorders and malignancies. We assessed whether overall survival (OS) at 100 days, which represents early transplant-related mortality (TRM), and at one year, which represents disease-related mortality and later TRM, had changed over time. The study population was derived from patients undergoing 38,060 first alloHCTs between 1994–2005 in US and Canadian centers and reported to the CIBMTR. Donor lymphocyte infusions were excluded. Statistical significance was measured using Ptrend over 6 time cohorts to test whether the OS estimates were stable (slope = 0), increasing (slope>0) or decreasing (slope<0) over time. The Day 100 and 1 year OS estimates are shown in the Table. Disease and disease status subgroups were defined a priori, and the OS estimates are not adjusted for any covariates such as age, Karnofsky status, etc. Marked improvements in 100-day survival were seen for all disease and disease status groups examined. Day 100 mortality rates in HLA-matched sibling alloHCT recipients during the most recent period (2004-5) were as low as 2% for CML treated in CP1, 6–8% for AML in CR1 and ALL in CR2, and a modest 12% for MDS. Even in alloHCT recipients with unrelated donors treated in 2004-5, the Day 100 mortality rates ranged from 9–22%, a significant decrease from historical mortality rates of 29–37%. Significant improvements in 1-year OS were noted for all groups undergoing unrelated-donor alloHCT; however, among those undergoing HLA-matched sibling alloHCT, significant improvements in 1-year OS were only seen in patients with CML in CP1 or MDS. OS has improved for many patients undergoing myeloablative alloHCT, which likely reflects improvement in supportive care and better patient/donor selection. Day 100 OS has significantly improved in all patients who received a myeloablative HLA-matched related or unrelated donor alloHCT. Significant improvement in 1-year OS was also experienced by most patients. Table: Overall survival (95% CI) estimates over time HLA-Matched Sibling Myeloablative Allogeneic HCT 1994-5 1996-7 1998-9 2000-1 2002-3 2004-5 Ptrend AML in CR1 N 370 370 383 376 384 440 <0.001 @100 days 85 (81–88) 87 (84–90) 90 (86–93) 88 (84–91) 92 (89–94) 94 (91–96) 0.1662 @1 year 69 (65–74) 70 (66–75) 72 (67–76) 67 (62–72) 74 (69–78) 75 (71–80) ALL in CR2+ N 179 186 149 159 156 163 0.0018 @100 days 77 (70–83) 82 (76–87) 88 (82–93) 85 (79–90) 85 (79–90) 92 (87–96) 0.2937 @1 year 62 (55–69) 63 (56–70) 69 (61–77) 59 (51–67) 64 (56–71) 70 (62–77) CML in CP1 N 483 540 492 317 155 125 <0.001 @100 days 84 (81–87) 88 (85–90) 89 (87–92) 91 (87–94) 99 (96–100) 98 (94–100) <0.001 @1 year 71 (66–75) 72 (68–76) 80 (76–83) 82 (77–86) 89 (83–93) 92 (86–96) MDS N 225 290 273 235 239 227 <0.001 @100 days 71 (65–77) 75 (70–80) 76 (71–81) 82 (77–87) 85 (80–89) 88 (84–92) 0.0488 @1 year 54 (48–61) 51 (45–57) 57 (51–63) 58 (51–65) 61 (55–68) 64 (58–71) Unrelated Donor Myeloablative Allogeneic HCT 1994-5 1996-7 1998-9 2000-1 2002-3 2004-5 Ptrend AML in CR1 N 52 75 88 135 182 336 <0.001 @100 days 63 (50–76) 64 (53–74) 69 (59–78) 75 (68–82) 82 (76–87) 86 (82–90) 0.0427 @1 year 48 (35–62) 35 (25–47) 48 (37–59) 51 (42–60) 54 (46–61) 56 (50–62) ALL in CR2+ N 129 151 132 116 164 197 <0.001 @100 days 66 (58–74) 70 (62–77) 71 (62–78) 75 (67–82) 78 (71–84) 91 (87–95) <0.001 @1 year 43 (34–51) 45 (37–53) 49 (40–58) 40 (31–50) 54 (46–62) 67 (60–74) CML in CP1 N 211 250 292 152 87 118 0.0006 @100 days 71 (65–77) 70 (64–75) 74 (69–79) 75 (68–81) 80 (71–88) 87 (81–93) 0.0057 @1 year 51 (44–57) 54 (48–61) 59 (53–64) 60 (52–68) 65 (54–75) 71 (62–80) MDS N 104 138 135 140 161 234 <0.001 @100 days 64 (54–73) 62 (54–70) 59 (51–67) 67 (59–75) 74 (67–81) 78 (72–83) <0.001 @1 year 41 (31–50) 44 (35–52) 35 (27–43) 45 (37–54) 52 (44–60) 57 (50–63) Disclosures: No relevant conflicts of interest to declare.

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Gundle, Kenneth R., Etasha M. Bhatt, Stephanie E. Punt, Viviana Bompadre, and Ernest U. Conrad. "Injection of Unicameral Bone Cysts with Bone Marrow Aspirate and Demineralized Bone Matrix Avoids Open Curettage and Bone Grafting in a Retrospective Cohort." Open Orthopaedics Journal 11, no. 1 (May 31, 2017): 486–92. http://dx.doi.org/10.2174/1874325001711010486.

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Background:Many treatment options exist for unicameral bone cysts (UBC), without clear evidence of superiority. Meta-analyses have been limited by small numbers of patients in specific anatomic and treatment subgroups. The purpose of this study was to report the outcomes of injecting bone marrow aspirate and demineralized bone matrix (BMA/DBM) for the treatment of proximal humerus UBC.Methods:Fifty-one patients with proximal humerus lesions treated by BMA/DBM injection were retrospectively reviewed from a single academic medical center.Results:The mean number of injections performed per patient was 2.14 (range 1-5). Eleven patients underwent only one injection (22%), an additional 19 patients completed treatment after two injections (37%), four patients healed after three injections (8%), and one patient healed after four injections (2%). The cumulative success rate of serial BMA/DBM injections was 22% (11/51), 58% (30/51), 67% (34/51), and 69% (35/51). Eleven patients (22%) ultimately underwent open curettage and bone grafting, and five patients (10%) were treated with injection of calcium phosphate bone substitute.Conclusion:A BMA/DBM injection strategy avoided an open procedure in 78% of patients with a proximal humerus UBC. The majority of patients underwent at least 2 injection treatments.Level of Evidence:Level IV retrospective cohort study.

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Annibali, Ombretta, Francesca Chiodi, Chiara Sarlo, Natalia Cenfra, Simona Tomassini, Sergio Mecarocci, Giuseppe Cimino, and Giuseppe Avvisati. "R-COMP Regimen in B Cell Non Hodgkin Lymphoma Patients with Cardiovascular Comorbidities." Blood 126, no. 23 (December 3, 2015): 5096. http://dx.doi.org/10.1182/blood.v126.23.5096.5096.

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Abstract Backgroung: Anthracyclines-based regimens remain the gold standard for the treatment of Lymphomas, although the associated cardiac toxicity may limit their use, especially in frail and elderly patients. Patients and Methods: From October 2008 to January 2015 we treated 51 newly diagnosed patients B cell with poor-risk non Hodgkin lymphoma and cardiovascular comorbidities using the R-COMP regimen (rituximab, cyclophosphamide, non-pegylated liposome-encapsulated doxorubicin, vincristine and prednisone). Median age was 72 years (range:46-82 yrs ; 62% ≥ 70 years). As for histology, 26/51 (50%) were Diffuse Large B-cell Lymphoma; 10/51 (20%) Follicular Lymphoma; 8/51 (16%)mantle cell lymphoma; 5/51 (10%) Nodal Marginal Zone Lymphoma; 2/51 (4%) other B-cell indolent Lymphoma. IPI and FLIPI prognostic scores were Intermediate to High in the majority (39/51 = 76%) of the patients. Stage III and IV according to Ann-Arbor staging system was present in 40/51 patients (78%). The median age adjusted Charlsons comorbidity index was 6 (range: 3 to 11). Cardiovascular risk factors were considered: hypertension (39/51pts = 76%), a history or recent acute myocardial infarction (9/51 pts = 17%) and Atrial fibrillation (4/51 = 8%). According to National Institute of Aging/National Cancer Institute (NIA/NCI index), a large portion of patients (39%) presented high-impact conditions mainly consisting of ischemic and arrhythmic diseases, under active treatment. Treatment was well tolerated and toxicities were limited grade III/IV cytopenia. RESULTS: Complete remission was achieved in 37/51 (72%) and partial response in 8/51 (15%). The remaining 12% of patients had a progressive disease . As of July 2015, after a median follow up period of 25 months (range 3-79), the OS, RD, EFS, TTF were not reached ( Figure 1, panel A,B,C respectively). In particular, at 5 years from the treatment starting, OS and RD are both 70% and EFS is 54% .Cardiac toxicity was observed in one patients who died for pulmonary edema, while two patients developed arrhythmias. Conclusions: This study confirm the efficacy and tolerability of R-COMP regimen in elderly patients with cardiovascular comorbidities. Figure 1. Figure 1. Disclosures No relevant conflicts of interest to declare.

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21

Masuda, Claudio Akio, and Mónica Montero-Lomelí. "An NH₂-terminal deleted plasma membrane H⁺-ATPase is a dominant negative mutant and is sequestered in endoplasmic reticulum derived structures." Biochemistry and Cell Biology 78, no. 1 (2000): 51–58. http://dx.doi.org/10.1139/bcb-78-1-51.

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Bolland, M. D. A., and R. F. Brennan. "Comparing the phosphorus requirements of wheat, lupin, and canola." Australian Journal of Agricultural Research 59, no. 11 (2008): 983. http://dx.doi.org/10.1071/ar07430.

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Spring wheat (Triticum aestivum L.), lupin (Lupinus angustifolius L.), and canola (Brassica napus L.) are the major crop species grown in rotation on the predominantly sandy soils of south-western Australia. Comparisons among the species for yield responses to applied phosphorus (P), effects of applied P on growth rates of shoots, P response efficiency for shoot and grain production, and the pattern for accumulation of P into shoots during growth and into grain at maturity are rare, or are not known, and were quantified in the glasshouse study reported here. Size and P content (P concentration multiplied by yield) of sown seed were in the order canola < wheat < lupin. Therefore, yield responses to applied P were first observed at ~10 days after sowing (DAS) for canola, ~17 DAS for wheat, and ~60 DAS for lupin. Lupin shoots showed no yield response to applied P at the first harvest at 51 DAS. Otherwise all species showed large yield, P concentration, and P content responses to applied P for all harvests at 51, 78, 87, 101, 121, and 172 DAS. To produce 90% of the maximum grain yield, the relevant data for cropping, lupin required ~67% less P than wheat, canola required ~40% less P than wheat, and canola required ~75% more P than lupin. Growth rates, and P response efficiency, were generally largest for canola, followed by wheat, then lupin. For shoots, P accumulation was in the order lupin > wheat > canola at 51 DAS, canola > wheat > lupin at 78 and 87 DAS, canola > wheat = lupin at 101 DAS, and all 3 species were about similar at 121 DAS. For accumulation of P into shoots plus grain at maturity (172 DAS) the order was canola > lupin > wheat, and for grain only was canola > wheat = lupin.

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Hopes, Lisa M., and Alan Williams. "Depression, Self-Defeating, and Self-Destructive Behaviors as Predictors of Suicide Ideation in Males and Females." Psychological Reports 84, no. 1 (February 1999): 63–66. http://dx.doi.org/10.2466/pr0.1999.84.1.63.

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Previous studies have implicated depression, self-defeating behaviors, and self-destructive behaviors in suicide ideation. The present research directly compared these three concepts as predictors of both males' (n = 51) and females' ( n = 78) suicide ideation. Analysis confirmed sex differences, with depression and self-defeating behaviors predicting females' suicide ideation, and self-destructive behaviors predicting males' suicide ideation. These results suggest that suicide may be related to these subtle yet relevant factors which may not be easily detected by mental health workers.

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24

MacGowan, A. P., K. E. Bowker, M. Wootton, H. A. Holt, and D. S. Reeves. "In Vitro Activities of Y-688, a New 7-Substituted Fluoroquinolone, against Anaerobic Bacteria." Antimicrobial Agents and Chemotherapy 42, no. 2 (February 1, 1998): 419–24. http://dx.doi.org/10.1128/aac.42.2.419.

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ABSTRACT The in vitro activities of Y-688, a new 7-substituted fluoroquinolone derivative, against 317 nonduplicate anaerobic isolates were determined. Eighty-five percent of the Bacteroides fragilis group (n = 89) were inhibited by ≤2 mg of Y-688 per liter, while 78, 100, 89, and 98% of gram-negative bacilli (n = 135), gram-positive cocci (n = 59), and non-spore-forming (n = 58) and spore-forming (n = 51) gram-positive bacilli, respectively, were inhibited by ≤1 mg of Y-688 per liter.

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Xia, Qiran, Chao Liu, Yan Xu, Shude Mao, and Shuang Gao. "The Velocity Distribution in the Solar Neighborhood from LAMOST Pilot Survey." Proceedings of the International Astronomical Union 9, S298 (May 2013): 447. http://dx.doi.org/10.1017/s1743921313007126.

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AbstractWe use 63,774 F/G dwarf stars from the LAMOST pilot survey to explore the velocity distribution in the solar neighborhood. The intrinsic UV distribution is reconstructed with a 20-Gaussian model using extreme deconvolution. We find at least two arcs, one extending from (−106, −3) to (94, −27) km/s and the other from (29, −9) to (78, −51) km/s. The arcs are qualitatively consistent with numerical simulations of the resonance induced by the Galactic bar and can be used to constrain its dynamical properties.

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Fan, Fei, Da-Peng Xu, Zheng-Xiang Xiong, Hai-Jia Li, Hai-Bei Xin, Huan Zhao, and Jin-Wei Zhang. "Clinical significance of intrapancreatic choledochal cyst excision in surgical management of type I choledochal cyst." Journal of International Medical Research 46, no. 3 (January 11, 2018): 1221–29. http://dx.doi.org/10.1177/0300060517728598.

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Objective To investigate the effectiveness of intrapancreatic choledochal cyst excision in treating type I choledochal cyst, and increase understanding of the need for thorough surgical management of the disease. Methods Primary and secondary (including multiple) surgical cases, treated between 2005 and 2015, were retrospectively analysed, and follow-up data of post-treatment effectiveness to date were reviewed. Differences in curative effects were compared between whole and partial excision of the choledochal cyst. Results Out of 350 cases, patients with whole excision of the choledochal cyst ( n = 272) experienced no associated symptoms in the long-term (3/272 [1.1%] experienced stomach ache or fever). Patients with partial resection of the choledochal cyst ( n = 78) developed associated symptoms, including new cyst, calculus of the bile duct (51/78 [65.4%]), and carcinogenesis (11/78 [14.1%]) in the residual intrapancreatic biliary duct. Post-treatment clinical manifestations were significantly different between patients with partial resection versus whole excision of the choledochal cyst ( P<0.05). Conclusion Surgical re-excision should be considered in patients with a residual intrapancreatic portion of the choledochal cyst due to prior incomplete surgery, regardless of clinical symptoms.

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Yilmazsoy, Yunus, and Umut Ozyer. "Long-term results of endovascular treatment for arteriovenous dialysis access thrombosis in 143 patients: A single center experience." Journal of Vascular Access 20, no. 5 (August 3, 2019): 545–52. http://dx.doi.org/10.1177/1129729819865808.

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Objective: This study aimed to determine the long-term patency duration and rate of thrombosis of autologous arteriovenous fistulas and synthetic grafts treated with endovascular methods in a large patient population. Methods: A total of 144 arteriovenous accesses (37 radiocephalic, 51 brachiobasilic, 41 brachiocephalic, and 15 femorofemoral) from 143 patients were included in the study. A total of 304 endovascular thrombolytic treatment procedures were performed for 94 (65%) arteriovenous fistula and 50 (35%) arteriovenous graft accesses. Results: The procedural technical success rate was 98.7%. The mean follow-up duration was 32.5 (range, 3–132) months. The primary patency rates for arteriovenous fistulas and arteriovenous grafts were 78% and 78% at 6 months, 66% and 63% at 1 year, and 45% and 0% at 36 months, respectively. The assisted primary patency rates for arteriovenous fistulas and arteriovenous grafts were 82% and 84% at 6 months, 71% and 69% at 1 year, 51% and 29% at 36 months, and 30% and 1% at 60 months, respectively. The secondary patency rates for arteriovenous fistulas and arteriovenous grafts were 94% and 93% at 6 months, 85% and 85% at 1 year, 58% and 59% at 36 months, and 47% and 48% at 60 months, respectively. Conclusion: Although the primary patency durations for arteriovenous fistulas were better after endovascular thrombolytic treatment than those for arteriovenous grafts, the long-term outcomes of assisted primary and secondary patency durations after repeated procedures were similar for both types of arteriovenous accesses.

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Ança Evaristo, Tainá, Alexsander Ferraz, Tatiana De Ávila Antunes, Natália Soares Martins, Felipe Geraldo Pappen, Alice Mueller, Júlia Somavilla Lignon, and Diego Moscarelli Pinto. "PRESENÇA DE HELMINTOS POTENCIALMENTE ZOONÓTICOS EM AMOSTRAS FECAIS AMBIENTAIS EM PRAÇAS DE JAGUARÃO (RS), BRASIL." Science And Animal Health 7, no. 3 (September 17, 2020): 209–20. http://dx.doi.org/10.15210/sah.v7i3.13789.

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O objetivo deste trabalho foi analisar a presença de parasitos com potencial zoonótico, em amostras de fezes, coletadas de duas praças do município de Jaguarão (RS). As coletas foram realizadas mensalmente, de agosto de 2016 a agosto de 2017. Em cada coleta, foram recolhidas três amostras de fezes de cada uma das praças, totalizando 78 amostras. As fezes foram processadas pelo método de Willis-Mollay. Do total de amostras (78), 55 apresentaram-se positivas para pelo menos um gênero de parasito, representando 70,51% do total. O parasito observado em maior frequência foi o Ancylostoma spp., presente em 51 amostras (65,38%). Os meses que apresentaram maior frequência de contaminação foram fevereiro e julho de 2017, com 100% das amostras positivas. Conforme os resultados obtidos, conclui-se que existe contaminação por Ancylostoma spp., Trichuris spp. e Toxocara spp. em praças da cidade de Jaguarão, Rio Grande do Sul.

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Nasution, Myrna Pratiwi. "KARAKTERISTIK PETANI KELAPA SAWIT DI KABUPATEN LABUHAN BATU UTARA." Agriprimatech 3, no. 2 (April 26, 2020): 46–52. http://dx.doi.org/10.34012/agriprimatech.v3i2.922.

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Penelitian ini bertujuan untuk mengidentifikasi karakteristik petani kelapa sawit yang terdapat di Kabupaten Labuhan Batu Utara. Penelitian ini dianalisis dengan bantuan 200 responden. Metode yang digunakan dalam penelitian ini adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa sebanyak 32 persen petani berada pada rentang usia 51-55 tahun, 36 persen memiliki pendidikan pada jenjang Sekolah Dasar (SD), 46 persen petani memiliki luas lahan sebesar 1-5 Ha, 33 persen petani telah berusahatani selama 0-5 tahun, 78 persen memiliki tanggungan sebanyak 1-5 orang dan seluruh petani memiliki lahan sendiri untuk berusahatani.

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30

Piers, Edward, Grace L. Jung, and Edward H. Ruediger. "Synthesis of functionalized bicyclo[3.2.1]octa-2,6-dienes by thermal rearrangement of substituted 6-exo-(1-alkenyl)bicyclo[3.1.0]hex-2-ene systems." Canadian Journal of Chemistry 65, no. 3 (March 1, 1987): 670–82. http://dx.doi.org/10.1139/v87-115.

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Thermolysis of each of the enol silyl ethers 31–35 affords, cleanly and efficiently, the bicyclo[3.2.1]octadienes 36–40, respectively. Similarly, thermal rearrangement of the enol silyl ether 50 provides the diene 51. Hydrolysis of 36, 37, and 39, and decarbomethoxylation of the resultant keto esters 41, 42, and 44, gives the ketones 46–48, respectively. The ketone 46 is also obtained by acid hydrolysis of 51. Conversion of 6-methyl-1-hepten-4-yn-3-ol (56) into the enol ether 63 is described. Thermolysis of 63 gives 64, which, upon acid hydrolysis, affords 65. Thermolysis of the enones 68 and 69 produces the bicyclic dienones 70 and 71, respectively. On the other hand, thermolysis of 73 and 74, derived from the enone 69, provides the C-8 exo substituted bicyclo[3.2.1]octa-2,6-dienes 75 and 76, which are transformed smoothly, by acid hydrolysis, into the ketones 77 and 78, respectively.

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Mastboim, Niv Samuel, Tanya Gottlieb, Isaac Srugo, Alain Gervaix, Meital Paz, Roy Navon, Olga Boico, et al. "2624. Viral Pneumonia in Children: Facing the Challenge Using the Host Response." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S914. http://dx.doi.org/10.1093/ofid/ofz360.2302.

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Abstract Background Diagnosing viral pneumonia in children is challenging. Chest radiographic imaging and clinical findings cannot reliably distinguish viral from bacterial pneumonia. Furthermore, pathogen-based diagnosis is limited by inaccessible site of infection and high asymptomatic detection rates. The objectives of this analysis were twofold: first, to establish pneumonia etiology by applying a rigorous expert panel process, and second, to evaluate whether a novel host-immune signature that integrates viral induced proteins TRAIL and IP-10 together with bacterial CRP, can accurately differentiate viral from bacterial pneumonia. Methods This analysis included 1025 febrile children enrolled in two multi-center clinical studies that evaluated the host-immune signature performance: ‘Curiosity’ study (Oved et al., PLoS One 2015) and ‘Pathfinder’ study (Srugo et al., Pediatrics 2017). Pneumonia etiology – viral or bacterial – was determined by a panel of 3 independent experts, after reviewing patients’ clinical, laboratory, microbiological, and radiological data. Only cases with majority panel assignment were included. The host-signature generated one of the three results: viral, equivocal or bacterial, based on predetermined cut-offs. Results A total of 709 children were eligible for analysis and had an expert panel etiology determination. Of them, 114 were diagnosed with pneumonia: 51 assigned viral and 63 assigned bacterial (Figure 1). The signature separated viral from bacterial pneumonia with a sensitivity of 94% (95% CI: 85%–99%) and specificity of 95% (85%–99%) with 14% equivocal test results. Out of the 51 children diagnosed with viral pneumonia by the expert panel, 40 (78%) were given antibiotics, and 43 (83%) underwent chest x-ray evaluation. The signature correctly classified 42 of these 51 viral children, indicating its potential to reduce antibiotic overuse rates by 4.4-fold (from 78% to 18%; P < 0.001) and chest x-ray examination by 4.8-fold (from 83% to 18%; P < 0.001). Conclusion The TRAIL/IP-10/CRP signature exhibits high accuracy for diagnosing viral pneumonia in children. The signature’s potential to safely decrease unnecessary antibiotics and chest radiographic imaging should be examined in future utility studies. Disclosures All authors: No reported disclosures.

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32

Grenz, R., F. D. Maul, R. Standke, H. Klepzig, G. Kober, and G. Hör. "Ergebnisse der kombinierten Myokardszintigraphie und Radionuklidventrikulographie vor und nach transluminaler Koronarang ioplastik kritischer Koronararterienstenosen." Nuklearmedizin 25, no. 03 (1986): 106–13. http://dx.doi.org/10.1055/s-0038-1624326.

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This study compares exercise radionuclide ventriculography (RNVG) and exercise myocardial scintigraphy with 201TI (MSC) both computed trisectorially. 137 patients before and after transluminal angioplasty (TCA) were investigated. While specificity equivalent was set at 90% for both methods (10% percentile of the controls [n = 29]) overall sensitivity for RNVG was 79% (n = 86) and for MSC 78% (n = 98). Sensitivity of RNVG for lesions of the posterior wall was lower than for the anterior wall: LAD stenoses 83% (n = 46), RCA stenoses 71 % (n = 17), and LCX stenoses 63% (n = 8). Sensitivity of MSC presents only a slight difference between anterior and posterior wall lesions: LAD stenoses 78% (n = 51), RCA stenoses 73% (n = 22), RCX stenoses 100% (n = 8). Reproducibility of pathological findings before and after non-successful TCA and the determination of the stenosed vessel was slightly better with MSC than with RNVG. Functional improvement after a successful TCA is predictable by MSC, whereas RNVG documents the functional improvement.

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CASTRO-COSTA, CARLOS M. DE, REINALDO B. ORIÁ, OTONI C. DO VALE, JOSÉ ARNALDO M. DE ARRUDA, WAGNER G. HORTA, JOSÉ ARTUR C. D'ALMEIDA, TEREZINHA J. T. SANTOS, RODRIGO S. N. RAMOS, and MARCUS A. C. GIFONI. "Motor neuron diseases in the University Hospital of Fortaleza (Northeastern Brazil): a clinico-demographic analysis of 87 cases." Arquivos de Neuro-Psiquiatria 58, no. 4 (December 2000): 986–89. http://dx.doi.org/10.1590/s0004-282x2000000600002.

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In this retrospective (1980-1998) study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil), a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs). Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS) diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA), 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP), 2 as progressive muscular atrophy (PMA) and 1 as monomelic amyotrophy (MA), and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17), 30 to 39 years (n= 18), 40 to 69 years (n= 39) and 70 to 78 years (n= 4). From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.

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Liguory, Olivier, Felicia David, Claudine Sarfati, Francis Derouin, and Jean-Michel Molina. "Determination of Types of Enterocytozoon bieneusiStrains Isolated from Patients with Intestinal Microsporidiosis." Journal of Clinical Microbiology 36, no. 7 (1998): 1882–85. http://dx.doi.org/10.1128/jcm.36.7.1882-1885.1998.

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To determine the types of Enterocytozoon bieneusistrains associated with intestinal microsporidiosis, we developed a rapid and efficient approach for typing parasites obtained from stool specimens by PCR-restriction fragment length polymorphism (PCR-RFLP). Typing was based on DNA polymorphism of the ribosomal DNA internal transcribed spacer (ITS) region of E. bieneusi. RFLPs generated with two restriction enzymes (NlaIII andFnu4HI) in PCR-amplified ITS products were used to classify strains into different lineages. This approach was successfully used to differentiate 78 strains that had been obtained from the stools of 65 patients with intestinal microsporidiosis. Among the 78 strains, we found four genetically unrelated lineages, showing the genetic diversity of E. bieneusi. Type I strains of E. bieneusi were found in a majority of the samples, accounting for 51 (78%) of the 65 microsporidiosis cases. In contrast, type II, III, and IV strains were found in only 8 (12%), 3 (5%), and 3 (5%) cases, respectively. All strains of E. bieneusi we have tested so far fall into one of four different lineages, and this study shows that human intestinal microsporidiosis is most often associated with type I strains. PCR-RFLP analysis of the ITS region of E. bieneusishould be useful for epidemiological studies.

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35

Kurtz, D. M., L. K. Tschetter, J. B. Allred, S. M. Geyer, P. J. Kurtin, W. D. Putnam, K. M. Rowland та ін. "SUBCUTANEOUS INTERLEUKIN-4 FOR RELAPSED NON-HODGKINʼS LYMPHOMA: A PHASE II TRIAL IN THE NORTH CENTRAL CANCER TREATMENT GROUP, NCCTG 91-78-51." Journal of Investigative Medicine 55, № 2 (березень 2007): S362. http://dx.doi.org/10.1097/00042871-200703010-00088.

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36

Martin, Jeffrey J. "Training and Performance Self-Efficacy, Affect, and Performance in Wheelchair Road Racers." Sport Psychologist 16, no. 4 (December 2002): 384–95. http://dx.doi.org/10.1123/tsp.16.4.384.

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In the current study, social cognitive theory was examined with athletes with disabilities. More specifically, hierarchical and self-regulatory performance self-efficacy, self-regulatory training self-efficacy, outcome confidence, and affect were examined with wheelchair road racers (N = 51). In accordance with social cognitive theory, moderate to strong significant relationships among 3 types of self-efficacy and outcome confidence were found (rs = .41 - .78). All forms of self-efficacy and positive affect (rs = .39 - .56) were also related providing additional support to social cognitive theory and the important relationships among training and performance related efficacy and affect in sport.

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37

Craven, LA. "A taxonomic revision of Heliotropium (Boraginaceae) in Australia." Australian Systematic Botany 9, no. 4 (1996): 521. http://dx.doi.org/10.1071/sb9960521.

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The taxonomy of the Australian representatives of Heliotropium (Boraginaceae) is revised in the first comprehensive treatment of the genus of the genus for Australian since the publication in 1868 of Bentha's 'Flora Australiensis' account. Eighty-one species are recognised for the area, of which 78 are regarded as indigenous (75 endemic) with the remaining three species believed to be of recent introduction. Of the 51 new names proposed, 50 are the result of the description of new species. The remaining new name is required due to a change in status. Biological aspects briefly mentioned include breeding system and myrmecochoty.

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38

Storring, P. L., S. A. Khan, Y. G. Mistry, and E. Diczfalusy. "Plasma clearance in the rat of the LH bioactivity of two human LH standards of differing molecular composition." Journal of Endocrinology 119, no. 2 (November 1988): 327–34. http://dx.doi.org/10.1677/joe.0.1190327.

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ABSTRACT The LH biological potency of the International Reference Preparation (IRP) of Human Pituitary LH for Immunoassay (IRP 68/40) relative to that of the 2nd IRP of Human Pituitary FSH and LH for Bioassay (IRP 78/549) is markedly greater when estimated by in-vitro interstitial cell testosterone production (TICT) bioassay than by in-vivo bioassay, and by the 4-h ovarian ascorbate depletion (OAAD) assay than by the 4-day seminal vesicle weight gain assay. Other preparations of human LH which, like IRP 68/40, were highly purified, showed a similar spectrum of bioactivity in these assay systems and also contained a higher proportion of more basic LH isoforms than are found in crude pituitary extracts such as IRP 78/549. In an attempt to explain these differences, a comparison was made of the plasma survival in rats of the LH bioactivity (by TICT assay) of these two preparations. Contrary to expectation, their relative plasma clearance rates over a 4-h period did not account for their differing bioactivities. The plasma half-life of the LH bioactivity (with 95% confidence limits) was estimated to be 42·4 (35·3–49·5) min for IRP 68/40 and 41·3 (31·5–51·0) min for IRP 78/549. Furthermore the time-course of action in vivo of IRP 78/549 did not appear to be more prolonged than that of IRP 68/40. Thus their plasma testosterone responses during the course of these 4-h plasma clearance studies were similar, and estimates of the LH potency of IRP 68/40 relative to that of IRP 78/549 were no greater by 2-h than by 4-h OAAD assay. The more basic isoforms of LH present in IRP 68/40 and in other purified human LH preparations may therefore differ from those in crude pituitary extracts, such as IRP 78/549, in their intrinsic activity to stimulate the different target cells in these assay systems rather than in their bioavailability in vivo. J. Endocr. (1988) 119, 327–334

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39

Sari, Sely Novita, Rizqi Prastowo, Rahmad Junaidi, and Amir Machmud. "Rapid Visual Screening of Building for Potential Ground Movement in Kalirejo, Kulonprogo, Yogyakarta." Jurnal Ilmiah Pendidikan Fisika Al-Biruni 9, no. 1 (April 30, 2020): 51–59. http://dx.doi.org/10.24042/jipfalbiruni.v9i1.5190.

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Landslides are the biggest threat in the Kalirejo area. The dynamics of land movements in the mountains often cause cracks and potentially collapse. Landslides due to land fractures caused building damage. This study aimed to analyze the condition of a simple building on the influence of land fracture. The method used was conducting a field survey of existing buildings in the Kalirejo area. The data of the surveys were the percentage of building damage and building categorization. From the results of the analysis, the percentages of buildings in the safe category were 78 buildings or 54.17%, the buildings of the unsafe category were 51 buildings or 35.42%, and buildings with the unsafe category were 15 buildings out of 144 surveyed building with the percentage of 10.42%. Based on the results of the analysis using the Rapid Visual Screening (RVS) method, 15 buildings with unsafe conditions need to be relocated because they do not use the minimum structure required for simple buildings while the 51 buildings with unsafe conditions, repairs must be made to the structure according to the minimum requirements of simple buildings

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40

King, J., and G. Haddock. "Neonatal Head Injuries Revisited." Scottish Medical Journal 54, no. 2 (May 2009): 34–36. http://dx.doi.org/10.1258/rsmsmj.54.2.34.

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Background Between 1999 and 2005, 51 neonates were admitted to the regional Neonatal Surgical Unit (NSU), Glasgow with a diagnosis of head injury. The aim of this retrospective study was to compare this cohort with those from an earlier review of similar cases. Methods and Results Cases were reviewed using a structured data collection proforma. Information obtained was then compared with the results of an identical review carried out in the same Unit between 1990 and 1996. In the present series, the majority of the injuries were caused by a fall (n=39 [78%]) and resulted in scalp haematomata (n=31 [62%]) and associated skull fractures (n=30 [60%]). Only one patient required significant intervention. Conclusion Comparing the two study periods, there has been a marked increase in the number of cases admitted with a diagnosis of head injury (n=51 v n=25). There has also been an increase in the number of intracranial haemorrhages reported, associated with an increase in the number of CT scans performed. Non-accidental injury remains uncommon in this patient group. Outcome was excellent for all patients.

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41

Piers, Edward, та Richard D. Tillyer. "Pd(0)-catalyzed addition of Me3SnSnMe3 to α,β-alkynic aldehydes and ketones. Synthesis of (Z)-β-trimethylstannyl α,β-alkenic aldehydes and ketones. Preparation and synthetic uses of substituted (Z)-4-trimethylstannyl-1,3-butadienes". Canadian Journal of Chemistry 74, № 11 (1 листопада 1996): 2048–63. http://dx.doi.org/10.1139/v96-234.

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Treatment (dry tetrahydrofuran, reflux) of the α,β-alkynic aldehydes 26–28 and ketones 29–36 with Me3SnSnMe3 in the presence of a catalytic amount of (Ph3P)4Pd provides fair to excellent yields of the corresponding (Z)-β-trimethylstannyl α,β-alkenic aldehydes 41–43 and ketones 44–51. The carbonyl compounds 41–51, upon reaction with methylenetriphenylphosphorane under suitable conditions, are smoothly converted into the (Z)-4-trimethylstannyl-1,3-butadienes 61–71, respectively. Treatment of the aldehyde 41 with the anion of trimethyl phosphonoacetate and the aldehyde 42 with the anion of the phosphonoacetate 73 produces excellent yields of the 5-trimethylstannyl-2,4-heptadienoates 72 and 74, respectively. The synthetic potential of (Z)-4-trimethylstannyl-1,3-butadienes is illustrated by the conversion of 62 into the functionalized, stereodefined conjugated dienes 76 and 78 and by transformation of 87 into the structurally novel diene 84. Diels–Alder reactions of 84 with tetracyanoethylene and dimethyl acetylenedicarboxylate provide the spiro[3.5]nonane derivatives 88 and 89, respectively. Key words: Diels–Alder cycloaddition, organocopper(I), transmetallation, alkylidenecyclobutane, (E)-4-lithio-1,3-butadienes, spiro[3.5]nonane.

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42

Edgington, Steve, Alan G. Buddie, Lukasz Tymo, David J. Hunt, Khuong B. Nguyen, Andrés I. France, Loreto M. Merino, and Dave Moore. "Steinernema australe n. sp. (Panagrolaimomorpha: Steinernematidae), a new entomopathogenic nematode from Isla Magdalena, Chile." Nematology 11, no. 5 (2009): 699–717. http://dx.doi.org/10.1163/156854108x399326.

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Abstract A new species of entomopathogenic nematode, Steinernema australe n. sp., was isolated from a soil sample taken close to the beach on Isla Magdalena, an island in the Pacific Ocean, 2 km from mainland Chile. Morphologically the new species belongs to the glaseri-group and is characterised by morphometrics of the infective juvenile which has a very long body of 1316 (1162-1484) μm, excretory pore located far posterior to the anterior extremity (110 (95-125) μm), exceptionally long tail of 103 (92-114) μm, H% = 51 (42-61), E% = 107 (94-122) and a ratio = 35 (31-38). The first generation male has 72 (55-78) μm long spicules, a 45 (36-51) μm long gubernaculum and SW% = 172 (118-196). The first generation female can be recognised by well developed double epiptygmata, the lack of a prominent postanal swelling, a mucron on the tail tip and (in 60% of individuals) one to two subsidiary mucrons. Sequences of the ITS and D2D3 regions of the ribosomal DNA confirm that S. australe n. sp. is a valid species.

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43

Inten, Yutta, Lelani Reniarti, and Alex Chairulfatah. "Hubungan Kadar Procalcitonindengan Demam Neutropenia pada Leukemia Limfoblastik Akut Anak." Sari Pediatri 17, no. 4 (October 26, 2016): 267. http://dx.doi.org/10.14238/sp17.4.2015.267-72.

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Latar belakang. Kejadian infeksi bakteri pada leukemia limfoblastik akut (LLA) lebih tinggi pada demam neutropenia (DN).Procalcitonin(PCT) memiliki sensitivitas dan spesifisitas yang lebih baik dibanding dengan C-reactive protein(CRP). Hal ini masih menjadi perdebatan, pada penelitian sebelumnya dinyatakan bahwa CRP lebih baik dibanding dengan PCT. Tujuan. Menentukan hubungan PCT dengan DN pada LLA anak dengan mengikutsertakan CRP. Metode. Penelitian potong lintang pada 78 subjek usia 0-13 tahun dengan DN dan demam tanpa neutropenia (DTN) yang memenuhi kriteria inklusi dilakukan pemeriksaan PCT serum. Pemilihan subjek secara consecutive sampling. Variabel dengan nilai p<0,25 pada analisis bivariat dilanjutkan analisis multivariat dengan rasio Odds (RO) dan interval kepercayaan (IK) 95%. Hasil.Di antara 78 pasien LLA didapatkan 27 DN dan 51 DTN. Hubungan kadar PCT dan CRP serum dengan DN berturut-turut RO 3,618 (IK95%: 1,227–10,665) dan RO 3,676 (IK95%: 1,22–11,028). Procalcitonin dan CRP memperlihatkan diskriminasi yang baik dengan AUC 0,752 (IK 95%: 0,639–0,866) serta kalibrasi yang kuat (p=0,692).Kesimpulan. Procalcitoninserum berhubungan dengan DN pada LLA anak yang meningkat hubungannya dengan mengikutsertakan CRP

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44

Govindarajan, R., and S. Parthasarathy. "Glycodelin: A possible new biological marker in colorectal cancer." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 20081. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20081.

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20081 Background: Glycodelin is a 28 kDa glycoprotein expressed in normal human reproductive tract. It is over expressed in various gynecological malignancies and vascular endothelium. Since angiogenesis has been associated with and antiangiogenic therapy is effective in colorectal cancer, it is possible that glycodelin could be a mediator in the pathogenesis and be a potential target in the treatment of this disorder. To assess whether the serum glycodelin was expressed in metastatic colorectal cancer, analysis of serum samples obtained from patients participating in a clinical trial were analyzed. Methods: Serum glycodelin levels from 19 controls (5 males, 9 premenopausal females and 5 postmenopausal females) and 24 patients with metastatic colorectal cancer (15 males and 9 females) enrolled into a phase II treatment protocol were measured. All patients had progressed on prior chemotherapy. Samples were obtained prior to the initiation of any further therapy. Glycodelin levels were measured by an Elisa based immuno assay using polyclonal antibodies raised against a peptide derived from the sequence of human glycodelin. Results: The median age of the patient populatin was 62.5 yrs. (range 29–78); of the males was 65 yrs. (range 57–78); of females was 58 yrs. (range 29–66). The median serum glycodelin level of whole control group was 41 nG/50μL (range 26–61); of 5 males 27 nG/50 μL (range 13–41); of 9 premenopausal females was 64 nG/50 μL (range 46–86); and of 5 postmenopausal women was 38 nG/ 50 μL (range 27–49). The median serum glycodelin level of patients with metastatic colorectal cancer was 128 nG/ 50 μL (range 51–523); of men was 128 nG/50 μL (range 51–523) and of women was 120 nG/50 μL(range 51–377). Serial glycodelin levels dropped by more than 50% in patients who had a clinical response or those who had stable disease. Conclusions: Serum glycodelin level was elevated in patients with metastatic colorectal cancer compared to controls. Whether glycodelin plays a role in the pathogenesis of colorectal cancer; can be a useful index to measure response and be useful as a potential target in the management of patients with colorectal cancers needs further evaluation. No significant financial relationships to disclose.

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Zamora Araya, José Andrey. "Análisis de confiabilidad de la Prueba de Diagnóstico Matemática en la Universidad Nacional de Costa Rica." Actualidades en Psicología 29, no. 119 (November 13, 2015): 153. http://dx.doi.org/10.15517/ap.v29i119.18693.

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El objetivo del presente estudio es evidenciar cómo la implementación de la teoría de respuesta a los ítems, en particular el modelo de Rasch, ha logrado mejorar los índices de confiabilidad de la prueba de diagnóstico matemático en la Universidad Nacional de Costa Rica, pasando de un alfa de .51 en el 2010 a uno de .78 en el 2012. El análisis psicométrico permitió brindar recomendación acerca de la construcción de la prueba que redundaron en mejores indicadores y elaboración de ítems para medir los diferentes niveles de habilidad que es el propósito fundamental de una prueba diagnóstica.

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46

Krivonis, T. G. "Гендерні аспекти сприйняття психосоціальної підтримки у пацієнтів на різних етапах перебігу онкологічного захворювання". Експериментальна і клінічна медицина 84, № 3 (20 серпня 2020): 41–45. http://dx.doi.org/10.35339/ekm.2019.84.03.06.

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На основі інформованої згоди було обстежено 286 онкологічних пацієнтів, з них: 174 жінки та 114 чоловіків. Хворих досліджували на різних етапах лікувального процесу, а саме: при першому зіткненні з захворюванням – 78 осіб жіночої та 51 особа чоловічої статі, та при поверненні хвороби чи її рецидиві – 96 осіб жіночої та 63 чоловічої статі. У жінок та чоловіків з онкологічним захворюванням прогресування хвороби спричиняло зниження показників, які характеризують психосоціальну підтримку та було викликано як суб’єктивними (особливості сприйняття), так і об’єктивними факторами (зростання потреб хворих і вимог до допомоги). Показники психосоціальної підтримки у жінок були кращими, ніж у чоловіків. Рівень психосоціальної підтримки суттєво відрізнявся залежно від рівня сімейної адаптації родини

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47

Luis, José A. S., Thiago M. De Aquino, Bruno F. Lira, Petrônio F. A. Filho, Marcus T. Scotti, Luciana Scotti, Ricardo O. De Moura, and Francisco J. B. Mendonça Junior. "Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives." Acta Pharmaceutica 64, no. 2 (June 1, 2014): 233–45. http://dx.doi.org/10.2478/acph-2014-0016.

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Abstract Seven new compounds have been synthetized in satisfactory yields (51-78 %) through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and 1,3,4-thiadiazolium- 5-thiolate (10a,b) with chloroacetic acid or methyl iodide: 1,3,4-thiadiazolium-5-methylthio- (11) and 5-thioacetate (12). The structure of the title compounds was elucidated by elemental analysis, IR, 1H and 13C NMR spectroscopy. The newly synthesized compounds 5a, 6a, 11 and 12 were evaluated for their ex vivo spasmolytic potential on four isolated smooth muscles (rat aorta and uterus, guinea pig ileum and trachea) and compared with scopolamine. Some of the compounds exhibited potent spasmolytic activity equal to or stronger than scopolamine

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48

Saghafi, Hamed, Roberto Palazzetti, Hossein Heidary, Tommaso Maria Brugo, Andrea Zucchelli, and Giangiacomo Minak. "Toughening Behavior of Carbon/Epoxy Laminates Interleaved by PSF/PVDF Composite Nanofibers." Applied Sciences 10, no. 16 (August 13, 2020): 5618. http://dx.doi.org/10.3390/app10165618.

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This paper presents an investigation on fracture behavior of carbon/epoxy composite laminates interleaved with electrospun nanofibers. Three different mats were manufactured and interleaved, using only polyvinylidene fluoride (PVDF), only polysulfone (PSF), and their combination. Mode-I and Mode-II fracture mechanics tests were conducted on virgin and nanomodified samples, and the results showed that PVDF and PSF nanofibers enhance the Mode-I critical energy release rate (GIC) by 66% and 51%, respectively, while using a combination of the two registered a 78% increment. The same phenomenon occurred under Mode-II loading. SEM micrographs were taken, to investigate the toughening mechanisms provided by the nanofibers.

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49

NG, HEOK HEE, and HEOK HUI TAN. "A new, uniquely patterned spiny eel (Teleostei: Mastacembelidae) from southern Borneo, Kalimantan Tengah, Indonesia." Zootaxa 4819, no. 1 (July 22, 2020): 170–78. http://dx.doi.org/10.11646/zootaxa.4819.1.9.

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A new species of Macrognathus of the M. aculeatus species group is described from the Kahayan River drainage in southern Borneo, Kalimantan Tengah, Indonesia. Macrognathus kris, new species, is distinguished from all Asian congeners in having the following unique combination of characters: rim of anterior nostril with two fimbriae and two fimbrules; 43–45 rostral tooth plates; 24–25 dorsal spines; 46–55 dorsal-fin rays; 51–59 anal-fin rays; 20–23 principal caudal-fin rays; 76–78 total vertebrae; body depth at anus 11.8–15.9% SL; color pattern consisting of light brown stripe on dorsum and 11–14 irregular pentagonal dark brown blotches on sides of body.

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50

Kurtz, D. M., L. K. Tschetter, J. B. Allred, S. M. Geyer, P. J. Kurtin, W. D. Putnam, K. M. Rowland, et al. "81 SUBCUTANEOUS INTERLEUKIN-4 FOR RELAPSED NON-HODGKIN'S LYMPHOMA: A PHASE II TRIAL IN THE NORTH CENTRAL CANCER TREATMENT GROUP, NCCTG 91-78-51." Journal of Investigative Medicine 55, no. 2 (March 1, 2007): S362.1—S362. http://dx.doi.org/10.1136/jim-55-02-81.

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