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1
Brown, J. Martin, David J. Carlson, and David J. Brenner. "The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?" International Journal of Radiation Oncology*Biology*Physics 88, no. 2 (February 2014): 254–62. http://dx.doi.org/10.1016/j.ijrobp.2013.07.022.
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Ollevier, Thierry, Jean-Emmanuel Bouchard, Valerie Desyroy, and Christian Tessier. "(RS,RS)-5-[Hydroxy(4-methylphenyl)methyl]furan-2(5H)-one." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (October 12, 2007): o4298. http://dx.doi.org/10.1107/s1600536807048817.
Анотація:
The crystal structure of the racemic title compound, C12H12O3, allowed the determination of the relative configuration at the two stereogenic centers. For the R,R isomer, the O—C—C—O and C—C—C—C torsion angles around the bond between the two methine C atoms are 62.38 (15) and −175.49 (13)°, respectively. The furan and tolyl groups are almost perpendicular, with a dihedral angle of 79.39 (5)°. Strong and linear intermolecular O—H...O hydrogen bonding (H...O = 2.04 Å and O—H...O = 177°) is observed between the hydroxyl group and the C=O oxygen.
3
Miller, Dave P., Valentina I. Petkov, and Steven Shak. "The performance of the 21-gene assay standard cutpoints of 18 and 31 in HR+, HER2- invasive breast cancer (BC), while waiting for TAILORx mid-range recurrence score results." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 537. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.537.
Анотація:
537 Background: The Recurrence Score (RS) was shown in NSABP B-20 to predict chemotherapy (CT) benefit for RS ≥31 and no CT benefit for RS <18. The TAILORx results for RS <11 (NEJM 2015) reported excellent outcomes with no opportunity for CT to add additional benefit. As we await TAILORx results for RS 11-25, we characterized BC specific mortality (BCSM) for RS groups (cutoffs of 11, 18, 25, and 31) in the population-based SEER study of pts treated based on RS. Methods: RS results were provided to SEER registries per their methods (npj Breast Cancer 2016). Pts diagnosed (Jan 2004 - Dec 2012) with N0 HR+ HER2- negative BC, and no prior malignancy were eligible. BCSM estimates by CT use were computed using standard cutpoints of 18 and 31 and TAILORx cutpoints of 11 and 25. Results: Among 49,681 with a RS, 9,486 (19%) had RS <11, 17,988 (36%) had RS 11-17, 14,541 (29%) had RS 18-25, 3,805 (8%) had RS 26-30, and 3,861 (8%) had RS ≥31. Reported CT use and 5-y BCSM increased with increasing RS. For pts with both RS <11 and RS 11-17, CT use was uncommon and 5-y BCSM was low regardless of CT use. For pts with RS 18-25, CT use was more common and the 5-y BCSM was about 1% regardless of CT use. For pts with RS of 26-30 or ≥31, CT was common, and lower 5-y BCSM was observed with CT reported yes than with CT reported no or unknown. Conclusions: Pts in real-world clinical practice with RS <11, consistent with TAILORx, and pts with RS 11-17 have low 5-y BCSM with limited CT use, supporting hormonal therapy alone for pts with RS <18. The high end of the TAILORx mid-range (18-25) also showed good 5-y BCSM both with and without CT, highlighting the importance of the randomized results of TAILORx. [Table: see text]
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Komrokji, Rami S., John Barnard, David P. Steensma, Amy E. DeZern, Gail J. Roboz, Najla Alali, Jaime Fensterl, Guillermo Garcia-Manero, and Mikkael A. Sekeres. "Ring Sideroblasts and SF3B1 Mutations in Myelodysplastic Syndromes (MDS): Are They Two Faces of the Same Coin? a Study on Behalf of the MDS Clinical Research Consortium (MDS CRC)." Blood 128, no. 22 (December 2, 2016): 4321. http://dx.doi.org/10.1182/blood.v128.22.4321.4321.
Анотація:
Abstract Introduction Recurrent somatic mutations in SF3B1, a gene encoding a spliceosome component, have been identified in patients (pts) with myelodysplastic syndromes (MDS). SF3B1 mutations (MT) are more commonly detected in pts with ring sideroblast (RS) morphology and are associated with favorable outcome. The proposed 2016 World Health Organization (WHO) MDS classification categorizes pts with >5% RS and SF3B1 MT as MDS with RS, in contrast to prior WHO classifications which required ≥15% RS regardless of genotype. In this study, we explored the prognostic value of RS and SF3B1 MT and assessed the validity of the new proposal. Methods We identified 471 pts with MDS and known SF3B1 mutational status from MDS CRC institutions. RS were assessed as present or absent (RS +/-) based on bone marrow aspirate reports (n=157); in cases where quantitative data on RS% were available (n=41), pts were grouped in the 5-15% RS group or > 15% RS group. Survival was calculated from time of diagnosis. Cox regression analysis was used to estimate hazard ratios for overall survival (OS) and AML free survival (AFS), which was defined as time to death or AML transformation, respectively. Chi-squared and Wilcoxon tests were used to test for differences in categorical and continuous distributions, respectively. Results: Among 471 pts with known SF3B1 mutational status, 76 (16%) had MT. Pts with MT had lower-risk International Prognostic Scoring System (IPSS) scores compared to SF3B1 wild-type (WT; 79% vs 57%, p < .001). Among pts with MT, 50% had RS + compared to 19% RS + in the WT group (p < .001). MT were independently associated with better OS (HR 0.48, p= .001) and longer AFS (HR 0.5, p <.005) after adjusting for age and IPSS. We compared outcomes of four groups: WT/RS-, MT/RS-, WT/RS+, and MT/ RS +. Adjusting for age and IPSS, pts with MT/RS + had the best outcome, with hazard ratios for AFS of 4.2 for WT/RS- vs. MT/RS+ (p =.018), 4.1 for MT/RS- vs. MT/RS+ (p =.045), and 5.1 for WT/RS+ vs. MT/RS+ (p= .01). We compared 7 pts with 5-15% RS to 22 pts with >15% RS. Among patients with RS 5-15%, 4/7 pts (57%) were classified as MDS with excess blasts compared to 24% for those RS >15% (p=.09). Pts with 5-15% RS were more likely to be thrombocytopenic (5/7, 71%) compared to >15% RS (29%, p=.04). One patient (14%) with 5-15% RS had MT compared to 12 (55%) pts with > 15% RS, p= .06. In Cox regression analysis using the RS 5-15% group as the reference, the hazard ratio for RS > 15% for AFS was 0.26 (p = .034) and the hazard ratio for MT for AFS was 0.08 (p= .002). Conclusions SF3B1 somatic mutations in MDS are commonly associated with RS, better OS and longer AML-free survival. Patients with RS and MT had a significantly better outcome than those with either isolated RS or MT, or neither. These data support incorporation of SF3B1 mutation status into the WHO classification regardless of RS percent, though with differentiation for those with RS and MT. Disclosures Komrokji: Novartis: Consultancy, Speakers Bureau; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Consultancy; Boehringer-Ingelheim: Research Funding. Roboz:Cellectis: Research Funding; Agios, Amgen, Amphivena, Astex, AstraZeneca, Boehringer Ingelheim, Celator, Celgene, Genoptix, Janssen, Juno, MEI Pharma, MedImmune, Novartis, Onconova, Pfizer, Roche/Genentech, Sunesis, Teva: Consultancy.
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Wang, Jui-Ling, Yu-Siang Chen, Kuo-Chin Huang, Chin-Hsing Yeh, Miles Chih-Ming Chen, Lawrence Shih-Hsin Wu, and Yi-Han Chiu. "Resistant Starch-Encapsulated Probiotics Attenuate Colorectal Cancer Cachexia and 5-Fluorouracil-Induced Microbial Dysbiosis." Biomedicines 12, no. 7 (June 28, 2024): 1450. http://dx.doi.org/10.3390/biomedicines12071450.
Анотація:
5-Fluorouracil (5-FU) is commonly used as the primary chemotherapy for colorectal cancer (CRC). However, it can lead to unwanted chemoresistance. Resistant starch (RS), which functions similarly to fermentable dietary fiber, has the potential to reduce the risk of CRC. The effects of RS on improving CRC-associated cachectic symptoms and 5-FU chemotherapy-induced microbial dysbiosis remain unknown. Female BALB/cByJNarl mice were randomly divided into four groups: one tumor group (with CT26 colonic carcinoma but no treatment) and three CT26 colonic carcinoma-bearing groups that were administered 20 mg/kg 5-FU (T+5-FU group), a probiotic cocktail (4 × 108 CFUs) plus chemotherapy (T+5-FU+Pro), or resistant-starch-encapsulated probiotics plus chemotherapy (T+5-FU+RS-Pro). T+5-FU and T+5-FU+RS-Pro administration significantly suppressed tumor growth and activated apoptotic cell death in CT26-bearing mice. 5-FU-induced increases in inflammatory cytokines and NF-κB signaling were mitigated by the Pro or RS-Pro supplementation. A gut microbial composition comparison indicated that the abundance of intestinal bacteria in the T and T+5-FU groups decreased significantly, while the groups receiving Pro or RS-Pro maintained a greater abundance and healthy gut microbiota composition, suggesting that RS can reduce the microbial dysbiosis that occurs during 5-FU chemotherapy. The use of RS-Pro before chemotherapy should be considered for the regulation of chemotherapy-associated cachectic symptoms, inflammation, and chemotherapy-induced microbial dysbiosis.
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Vallero, Daniel A., and Paul J. Lioy. "The 5 Rs: Reliable Postdisaster Exposure Assessment." Leadership and Management in Engineering 12, no. 4 (October 2012): 247–53. http://dx.doi.org/10.1061/(asce)lm.1943-5630.0000200.
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Park, Seok-Rae, Younghwan Han, Su Jeong Lee, and Ki-Il Lee. "Efficacy of Low-Level Laser Therapy in a Rabbit Model of Rhinosinusitis." International Journal of Molecular Sciences 24, no. 1 (January 1, 2023): 760. http://dx.doi.org/10.3390/ijms24010760.
Анотація:
Little is known about alternative treatment options for rhinosinusitis (RS). We aimed to evaluate the efficacy of low-level laser therapy (LLLT) for RS in experimentally induced rabbit models of RS. A total of 18 rabbits were divided into four groups: a negative control group (n = 3), an RS group without treatment (n = 5, positive control group), an RS group with natural recovery (n = 5, natural recovery group), and an RS group with laser irradiation (n = 5, laser-treated group). Computed tomography and histopathological staining were performed for each group. mRNA and protein expression levels of local cytokines (IFN-γ, IL-17, and IL-5) were also measured. Tissue inflammation revealed a significant improvement in the laser-treated group compared with the RS and natural recovery groups (p < 0.01). In addition, sinus opacification in the CT scans and cytokine expression was reduced in the laser-treated group, though without statistical significance. LLLT could be an effective option for the management of RS concerning radiological, histological, and molecular parameters.
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Prabhakar, Pramod, Ram Pal Singh, Ramesh Pandey, Neeraj, and Anand Kumar Singh. "Evaluation of the repeatability of male calves' birth weights in different grades of Jersey x Red Sindhi crosses." EMERGENT LIFE SCIENCES RESEARCH 09, no. 02 (2023): 215–20. http://dx.doi.org/10.31783/elsr.2023.92215220.
Анотація:
To assess the consistency of birth weight among male calves born to half-J x half-RS, quarter-J x ¾ RS, three-eighths Jersey x five-eighths RS, and one-eighth J x seven-eight RS cows. The SHUATS in Prayagraj, Uttar Pradesh, India obtained the data from a pedigree cum history sheet. Male calves born to 77 cows during the first (L1), second (L2), and third (L3) lactations, as well as 127 observations of Jersey x Red Sindhi cows of varying quality, were all measured and recorded in kilos. Increased reproducibility across many cross-breed dairy cow performance tiers indicates superiority. This research shows that choosing cows with higher estimations based on the birth weight. of their male calves can increase the output of herds. The mean of birth weight of male calves L1, L2, and L3 were 18.11, 20.15, 22.07 kg. of ½ J × ½ RS, 20.50, 19.88, 20.77 Kg f ¼ J × ¾ RS crosses, 20.06, 20.88, 22.24 kg. of 3/8 J × 5/8 RS, 19.08, 18.76, 22.83 kg of 1/8 J ×7/8 R.S proportionately. The ranges of birth weight of male calves from the Ist (L1), IInd (L2) and third (L3) lactations were 15.80 - 20.10, 15.80 - 26.6, 19.6 - 25.8 kg. of ½ J × ½ RS, 15.42 - 24.94, 14.51 - 25.70, 13.6 - 28.12 Kg. of ¼ J × ¾ R.S, 14.96 - 26.40, 16.32 - 24.30, 15.42 - 27.50 kg. of 3/8 J × 5/8 RS crosses, 15.87 - 24.23, 12.70 - 24.51, 18.14 - 25.80 kg. of 1/8 J ×7/8 RS respectively. The mean of birth weight of male calves was 20.13 kg. of ½ J × ½ RS, 17.68 Kg. of ¼ J × ¾ RS, 21.07 kg. of 3/8 J × 5/8 RS, 19.92 kg. of 1/8 J ×7/8 RS respectively. The highest birth weight of male calves were 25.8 Kg. and the lowest 15.80 Kg of ½ J × ½ R.S, 28.12 kg. highest and lowest 13.60 kg. of ¼ J × ¾ RS, 27.50 kg at highest and lowest 14.96 kg of 3/8 J × 5/8 RS, 25.8 kg at highest and lowest 12.70 kg. of 1/8 J ×7/8 RS, respectively. The repeatability of birth weight of male calves for 0.60 ± 0.20 of ½ J × ½ RS, 0.46 ± 0.19 of ¼ J × ¾ RS, 0.78 ± 0.15 of 3/8 J × 5/8 RS, 0.57 ± 0.15 of 1/8 J ×7/8 RS. The more repeatability for various grades of crossbred dairy cattle shows better performance.
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Rossi, Davide, Daniela Capello, Michaela Cerri, Clara Deambrogi, Stefania Cresta, Silvia Rasi, Valeria Spina, et al. "Molecular, Phenotypic and Clinical Predictors of Richter Syndrome (RS) in Chronic Lymphocytic Leukemia (CLL)." Blood 110, no. 11 (November 16, 2007): 3086. http://dx.doi.org/10.1182/blood.v110.11.3086.3086.
Анотація:
Abstract RS occurs in 5–15% CLL, depending on follow-up length and re-biopsy policy. The value of biological and clinical risk factors in predicting RS is unknown and represents the aim of this study. The analysis was based on a consecutive series of 185 CLL. Diagnosis of RS was based on lymph node or extranodal tissue biopsy. RS was diagnosed in 17 cases all represented by diffuse large B-cell lymphoma (DLBCL). Cumulative incidence of RS at 5 and 10 years was 13.6% (95%CI: 7.0–20.1%) and 16.2% (95%CI: 8.0–24.4%), respectively. Transformation plateaued at 82 months of follow-up. Median time to transformation was 23.0 months (95%CI: 15.9–30.1 months) from CLL diagnosis. IGHV studies documented clonal relationship between CLL and DLBCL in 15/17 (88.2%) cases. At the time of CLL diagnosis, molecular variables predicting RS were: IGHV4–39 usage (5-year risk IGHV4-39: 56.2% vs IGHVnon-VH4-39: 11.2%; p<0.001), IGHV homology ≥98% (5-year risk IGHV homology ≥98%: 28.3% vs IGHV homology <98%: 7.0%; p=0.006), absence of del13q14 (5-year risk non-del13q14: 23.1% vs del13q14: 3.8%; p=0.006), and presence of +12 (5-year risk +12: 19.5% vs non +12 10.0%; p=0.027). CLL with p53 inactivation by p53 mutation and/or del17p13 had a trend toward an increased risk of transformation (5-year risk del17p13/p53 mutation: 24.6% vs non-del17p13/p53 mutation: 12.1%; p=0.061). Cluster analysis revealed that 6/17 (35.2%) CLL evolving to RS carried stereotyped CDR3s. Utilization of stereotyped IGHV4-39 or stereotyped IGHV1-2/1-3 predicted transformation (5-year risk stereotyped CDR3: 63.0%; p<0.001). Del11q22-q23, normal FISH katyotype, BCL2 C938A polymorphism, and telomere length did not predict RS. Among phenotypic markers at CLL diagnosis, expression of both CD38 (5-year risk CD38+: 25.4% vs CD38−: 4.7%; p<0.001) and ZAP70 (5-year risk ZAP70+ 27.9% vs ZAP70− 6.7%; p=0.002) predicted RS. At the time of CLL diagnosis, clinical variables predicting RS included: lymph node size ≥3 cm (5-year risk lymph node ≥3 cm: 49.1% vs lymph node <3 cm: 6.1%; p<0.001), involvement of 3 nodal areas (5-year risk 3 nodal areas: 31.8% vs nodal areas <2: 8.3%; p<0.001), Binet B stage (5-year risk Binet B: 40.8% vs Binet C 20% vs Binet A: 7.1%; p=0.003), and LDH ≥1.2 × ULN (5-year risk LDH >1.2 × ULN: 37.5% vs LDH <1.2 × ULN: 8.6%; p=0.001). Age, sex, Rai stage, splenomegaly, Hb, platelet count, percentage of BM lymphocytes, B2M, ALP, albumin and lymphocyte doubling time did not predict RS. Landmark analysis at 12, 24, 36, 48 and 60 months documented: a significantly increased risk of subsequent RS in progressive CLL vs stable CLL starting from 24 months; and no RS in stable CLL after 48 months of follow up. Multivariate analysis identified CD38 expression (HR 4.22, 95%CI 1.26–14.05; p= 0.019) and IGHV4-39 usage (HR 4.29, 95%CI 1.28–14.29; p=0.018) as biological predictors of RS, and lymph node ≥3 cm as clinical predictor of RS (HR 8.73, 95%CI 2.45–31.05; p=0.001). Our data suggest that RS is predicted by: predominant nodal disease at diagnosis; CD38 expression; and usage of specific IGHV genes, namely IGHV4-39. These results suggest the need for a close monitoring and a careful biopsy policy in patients with molecular, phenotypic and clinical predictors of RS identified at the time of CLL diagnosis.
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Wolmark, Norman, Eleftherios P. Mamounas, Frederick L. Baehner, Steven M. Butler, Gong Tang, Farid Jamshidian, Amy P. Sing, Steven Shak, and Soonmyung Paik. "Prognostic Impact of the Combination of Recurrence Score and Quantitative Estrogen Receptor Expression (ESR1) on Predicting Late Distant Recurrence Risk in Estrogen Receptor–Positive Breast Cancer After 5 Years of Tamoxifen: Results From NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-28 and B-14." Journal of Clinical Oncology 34, no. 20 (July 10, 2016): 2350–58. http://dx.doi.org/10.1200/jco.2015.62.6630.
Анотація:
Purpose We determined the utility of the 21-Gene Recurrence Score (RS) in predicting late (> 5 years) distant recurrence (LDR) in stage I and II breast cancer within high and low-ESR1–expressing groups. Patients and Methods RS was assessed in chemotherapy/tamoxifen-treated, estrogen receptor (ER) –positive, node-positive National Surgical Adjuvant Breast and Bowel Project B-28 patients and tamoxifen-treated, ER-positive, node-negative B-14 patients. The association of the RS with risk of distant recurrence (DR) 0 to 5 years and those at risk > 5 years was assessed. An ESR1 expression cut point was optimized in B-28 and tested in B-14. Results Median follow-up was 11.2 years for B-28 and 13.9 years for B-14. Of 1,065 B-28 patients, 36% had low (< 18), 34% intermediate (18 to 30), and 30% high (≥ 31) RS. Of 668 B-14 patients, 51% had low, 22% intermediate, and 27% high RS. Median ESR1 expression by reverse transcriptase polymerase chain reaction was: B-28, 9.7 normalized expression cycle threshold units (CT) and B-14, 10.7 CT. In B-28, RS was associated with DR 0 to 5 years (log-rank P < .001) and > 5 to 10 years (log-rank P = .02) regardless of ESR1 expression. An ESR1 expression cut point of 9.1 CT was identified in B-28. It was validated in B-14 patients for whom the RS was associated with DR in years 5 to 15: 6.8% (95% CI, 4.4% to 10.6%) versus 11.2% (95% CI, 6.2% to 19.9%) versus 16.4% (95% CI, 10.2% to 25.7%) for RS < 18, RS 18 to 30, and RS ≥ 31, respectively (log-rank P = .01). Conclusion For LDR, RS is strongly prognostic in patients with higher quantitative ESR1. Risk of LDR is relatively low for patients with low RS. These results suggest the value of extended tamoxifen therapy merits evaluation in patients with intermediate and high RS with higher ESR1 expression at initial diagnosis.
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Rossi, Davide, Valeria Spina, Michaela Cerri, Clara Deambrogi, Lorenzo De Paoli, Luca Laurenti, Rossana Maffei, et al. "Usage of IGHV4-39 with Stereotypic B Cell Receptor Is An Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome." Blood 112, no. 11 (November 16, 2008): 778. http://dx.doi.org/10.1182/blood.v112.11.778.778.
Анотація:
Abstract Richter’s syndrome (RS) represents the transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma, mainly occurring as diffuse large B-cell lymphoma (DLBCL). The biology of CLL transformation to RS is poorly understood and knowledge on risk factors of RS development is scant. We tested whether IGHV gene usage and stereotypic B cell receptor (BCR) at CLL diagnosis have an impact on RS transformation. The first step of the study consisted of a case-control analysis comparing IGHV gene usage and prevalence of stereotypic HCDR3 in RS (n=69; all DLBCL) versus a control group (n=715) of CLL that had not transformed to RS. The second step consisted of an actuarial assessment of the impact of IGHV gene usage and stereotypic HCDR3 at CLL diagnosis, on the risk of subsequent transformation to RS in a cohort of 754 CLL, of which 39 had transformed to RS. Comparison of IGHV usage in unmutated RS versus unmutated control CLL documented that IGHV4-39 was the sole gene preferentially utilized (6/48, 12.5% vs 5/277, 1.8%, respectively, p=.002) by RS. Prevalence of stereotypic HCDR3 was significantly higher in RS compared to non-transformed CLL when considering all cases (RS: 50.7% vs non-transformed CLL: 22.2%; p<.000001), unmutated cases only (RS: 58.3% vs non-transformed CLL: 35.7%; p=.003), and mutated cases only (RS: 33.3% vs non-transformed CLL: 13.7%; p=.022). Compared to non-transformed CLL, RS preferentially utilized BCR belonging to a subset characterized by rearrangement of unmutated IGHV4-39/IGHD6-13/IGHJ5 genes (2/159, 1.2% vs 5/35, 14.3%, respectively; p=.002). All cases with stereotypic IGHV4-39 carried +12 as the sole FISH abnormality. After a median follow-up of 41.1 months, 39/754 CLL had transformed to RS. Univariate analysis documented: shorter time to transformation in CLL utilizing IGHV4-39 (5-year risk: 35.4%) compared to CLL utilizing other IGHV genes (5-year risk: 5.6%) (p<.000001); higher risk of RS in CLL utilizing stereotypic HCDR3 (5-year risk: 14.2%) compared to CLL without stereotypic HCDR3 (5-year risk: 3.9%) (p<.00001). CLL with stereotypic HCDR3 and IGHV homology 98% showed a significantly higher risk of transformation (5-year risk: 18.4%) compared to CLL with IGHV homology 98% but without stereotypic HCDR3 (5-year risk: 6.8%) (p=.006). Also, stereotypic HCDR3 identified a CLL subgroup that, despite presenting with IGHV homology <98%, showed an increased risk of RS (p=.040). This observation indicates that stereotypic HCDR3 is not a surrogate of IGHV homology for RS prediction. We then tested the independent predictive value for RS transformation of IGHV4-39 usage and of stereotypic HCDR3. Multivariate analysis selected IGHV4-39 usage (HR: 4.25; p=.002) and stereotypic HCDR3 at CLL diagnosis (HR: 3.08; p=.002) as independent predictors of RS transformation. The observation that all RS utilizing IGHV4-39 carried stereotypic HCDR3 prompted investigation of the interaction between IGHV4-39 usage and stereotypic HCDR3 in the model. Multivariate analysis selected the interaction between IGHV4-39 usage and stereotypic HCDR3 at CLL diagnosis as the strongest independent predictor of RS transformation (HR: 5.13; p=.001). The relevance of the interaction between IGHV4-39 and stereotypic HCDR3 was confirmed by bivariate log rank analysis. Accordingly, CLL utilizing both IGHV4-39 and stereotypic HCDR3 were identified as the disease category with highest risk of transformation (5-year risk: 68.7%). Transformation to RS and progression to symptomatic disease according to NCI Working Group guidelines are distinct events in CLL. Accordingly, neither IGHV4-39 usage nor stereotypic HCDR3 affected the risk of CLL progression occurring without transformation to RS. IGHV4-39 usage and stereotypic HCDR3 may be appropriate biological markers for RS prediction since: these markers predict RS in a fashion that is independent of other clinical and biological features; given the widespread use of IGHV sequencing for CLL prognostication, information on IGHV4-39 and stereotypic HCDR3 may be obtained at CLL diagnosis without additional testing; and importantly all CLL with concomitant IGHV4-39 usage and stereotypic HCDR3 ultimately transform to RS. A close monitoring and a careful biopsy policy may be of help for early recognition of RS transformation in patients carrying IGHV4-39 usage and stereotypic HCDR3.
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Gong, Lin, Jia-Wen Zhang, Ru-Tie Yin, Ping Wang, Hui Liu, Ying Zheng, Jiang-Yan Lou, and Zhi-Lan Peng. "Safety and Efficacy of Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Radical Surgery Alone in Locally Advanced Cervical Cancer Patients." International Journal of Gynecologic Cancer 26, no. 4 (May 2016): 722–28. http://dx.doi.org/10.1097/igc.0000000000000658.
Анотація:
ObjectivesThis study aimed to evaluate the safety and efficacy of neoadjuvant chemotherapy (NACT) followed by radical surgery (RS) among patients with locally advanced cervical cancer (LACC).MethodsEight hundred patients with LACC received either NACT followed by RS (NACT–RS) or RS alone. The primary outcome measures assessed the efficacy and adverse effects of NACT. Secondary outcome measures compared the preoperative clinical stage to the postoperative pathologic stage in NACT–RS and RS patients, assessed intraoperative and postoperative complications, including the adverse effects of postoperative radiotherapy and radiochemotherapy, and estimated the 5-year progression-free survival and 5-year overall survival.ResultsThe clinical response to NACT was 89.54%. Patients in the NACT–RS group had lower preoperative hemoglobin levels (115.20 vs 122.04 g/L, P < 0.001), a longer operative time (mean, 233.66 vs 224.37 minutes, P = 0.008), more intraoperative bleeding (750.34 vs 684.41 mL, P = 0.011), a shorter duration of catheter use (mean, 29.84 vs 32.14 days, P = 0.036), and a lower incidence of postoperative complications (7.30% vs 13.62%, P = 0.002) and postoperative radiotherapeutic and radiochemotherapeutic adverse effects (3.16% vs 4.63%, P < 0.001) compared to patients in the RS group. The 5-year progression-free survival and 5-year overall survival were 80.30% and 81.10% in the NACT–RS group and 81.00% and 78.50% in the RS group (P > 0.05). Pathological poor differentiation, nonsquamous cell carcinoma, parametrial invasion, positive pelvic lymph node, and lymphovascular invasion (P < 0.05) were independent risk factors for recurrence.ConclusionsNeoadjuvant chemotherapy may reduce RS-associated complications and postoperative radiotherapeutic and radiochemotherapeutic adverse effects in Chinese patients with LACC.
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Baehner, Frederick L., Steven Shak, Dave P. Miller, and Valentina I. Petkov. "SEER study of breast cancer specific mortality (BCSM) in patients with lobular tumors treated based on recurrence score results." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 11568. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.11568.
Анотація:
11568 Background: Linking the 21-gene assay RS result to the SEER Registries demonstrated very low 5-y BCSM with low RS and high 5-y BCSM with high RS across subgroups, such as nodal status, age, tumor size and grade (npj Breast Cancer 2016). Given the large sample size and interest in outcomes as a function of tumor characteristics, we characterized the relationship between RS results and BCSM in patients reported by SEER with lobular morphology. Methods: Patients with RS and lobular morphology based on the registry ICD-O-3 code 8520 were eligible if node negative (N0) or node positive up to 3 positive nodes (N+mic,1-3), HR+, HER2- negative, no prior malignancy, and diagnosed between Jan 2004 and Dec 2012. No information in SEER is available regarding lobulars, ie., trabecular, alveolar, solid and pleomorphic. 5-y BCSM was estimated using actuarial methods. Results: There were 6,075 eligible patients reported with lobular morphology (11% of cases). Median age was 59 years; 88%/12% were N0/N+; 31%/62%/7% grade 1/2/3; 61%/39% ≤2 cm/>2 cm. Median follow-up was 44 months. A minority (8%) had RS >25. Chemotherapy (CT) use and BCSM increased with increasing RS. In multivariable analysis in N0 disease, continuous RS result and tumor size predicted BCSM (p=0.003 and p=0.04, respectively), whereas age and tumor grade were non-significant. In multivariable analysis in N+ disease, continuous RS result alone predicted BCSM (p=0.002). Conclusions: In these analyses the prognosis of patients with lobular breast cancer treated based on RS results depends on both nodal status and the RS result. The 5-y BCSM for lobular breast cancer is excellent with RS of 25 or less, and increases for RS >25. [Table: see text]
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Patnaik, Mrinal M., Curtis A. Hanson, Nanna H. Sulai, Janice M. Hodnefield, Ryan A. Knudson, Rhett P. Ketterling, Terra L. Lasho, and Ayalew Tefferi. "Prognostic irrelevance of ring sideroblast percentage in World Health Organization–defined myelodysplastic syndromes without excess blasts." Blood 119, no. 24 (June 14, 2012): 5674–77. http://dx.doi.org/10.1182/blood-2012-03-415356.
Анотація:
Abstract The presence of ≥ 15% bone marrow (BM) ring sideroblasts (RS) and < 5% blasts is required for a diagnosis of refractory anemia with ring sideroblasts. We examined the phenotypic and prognostic relevance of this “15%” RS threshold in 200 patients with myelodysplastic syndromes (MDS) without excess blasts and with ≥ 1% RS. The impact of RS% was assessed both as a continuous and categorical variable: < 5% (n = 56), 5%-14% (n = 32), 15%-50% (n = 79), and > 50% (n = 33). RS% correlated (P < .05) directly with age, platelet count, transfusion dependency, BM cellularity, and mutant SF3B1 and inversely with hemoglobin level, multilineage dysplasia, and high-risk karyotype; but did not correlate with IDH mutations. At a median follow-up of 33 months, 156 (73%) deaths and 24 (12%) leukemic transformations were documented. Neither univariate nor multivariable analysis showed significant effect for RS% on overall or leukemia-free survival, suggesting the limited prognostic value of quantifying BM RS in MDS.
15
Lu, Ning, Xing-Ren Liu, Zhang-Liu Du, Yi-Ding Wang, and Qing-Zhong Zhang. "Effect of biochar on soil respiration in the maize growing season after 5 years of consecutive application." Soil Research 52, no. 5 (2014): 505. http://dx.doi.org/10.1071/sr13239.
Анотація:
The effect of biochar on soil respiration (Rs) over one maize-growing season was studied after 5 years of consecutive application in an intensive cropland in the North China Plain. The experiment was carried out in randomly arranged plots with four treatments being evaluated. Three replications were conducted per treatment: a control plot without biochar addition (CK), biochar incorporated at 4.5 t ha–1 year–1 (BC4.5), biochar incorporated at 9.0 t ha–1 year–1 (BC9.0), and incorporated wheat straw (SR). The Rs was determined throughout the growing season of maize in 2012. Soil temperature and moisture were measured simultaneously at 5 cm depth. The results showed that the seasonal and diurnal variations of Rs in the four different treatments were approximately equal, and there was a positive correlation between Rs and soil temperature. The Rs values of treatments BC4.5 and BC9.0 were significantly lower than of SR but not CK. Significant correlations between Rs and soil temperature and soil moisture were observed. Soil temperature had a stronger effect on Rs than did soil moisture, and Rs was more sensitive to soil temperature in the biochar treatments than in the SR and CK treatments. The application of biochar and straw increased the soil active organic carbon content, but an obvious relationship between Rs and the soil active organic carbon content was not found.
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Wang, Jinlong, Xuemin He, Wen Ma, Zhoukang Li, Yudong Chen, and Guanghui Lv. "Spatial Scale Effects of Soil Respiration in Arid Desert Tugai Forest: Responses to Plant Functional Traits and Soil Abiotic Factors." Forests 13, no. 7 (June 25, 2022): 1001. http://dx.doi.org/10.3390/f13071001.
Анотація:
Understanding the spatial variation law of soil respiration (Rs) and its influencing factors is very important when simulating and predicting the terrestrial carbon cycle process. However, there are still limitations in understanding how different sampling scales affect the spatial heterogeneity of Rs and whether the spatial scale effect will change with habitat types. Our objectives were to explore the effects of different sampling scales on the spatial variability of Rs and the relative importance of soil abiotic characteristics and plant traits in influencing the spatial variability of Rs. The Rs, soil properties, and plant traits were measured through field investigation and indoor analysis in the Tugai forest desert plant community in the Ebinur Lake Basin in northwest China. The Rs showed significant water gradient changes, with a coefficient of variation of 35.4%–58%. Plot types had significant effects on Rs, while the change of sampling scale did not lead to significant differences in Rs. At the plot scale, Rs spatial variation at the 5 m × 5 m sampling scale mainly depended on plant traits (leaf length, leaf thickness, leaf dry matter content, and leaf phosphorus content, p < 0.05), while Rs spatial variation at the 10 m × 10 m scale mainly depended on soil properties (soil total phosphorus, ammonium nitrogen, soil water content, and pH, p < 0.05). At the local scale, soil nutrients (soil available phosphorus and ammonium nitrogen) and plant traits (maximum plant height, leaf length, and phosphorus content) at the 5 m × 5 m scale jointly explained 49% of the spatial change of Rs. In contrast, soil microclimate (soil water content), soil nutrients (soil pH, available phosphorus, and nitrate nitrogen), and plant traits (leaf thickness) jointly explained 51% of the spatial variation of Rs at the 10 m × 10 m scale. These results demonstrate the potential to predict the spatial variability of Rs based on the combination of easily measured aboveground functional traits and soil properties, which provides new ideas and perspectives for further understanding the mechanism of Rs change in Tugai forests.
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Natalia Krisnawati, Gita, Sucipto Sucipto, and Rina Firliana. "EVALUASI PENERAPAN SIM-RS MENGGUNAKAN COBIT 5 PADA RSUD LAWANG." Antivirus : Jurnal Ilmiah Teknik Informatika 13, no. 2 (November 30, 2019): 80–89. http://dx.doi.org/10.35457/antivirus.v13i2.858.
Анотація:
Information technology (IT) has become a crucial part for companies or institutions with enterprise scale. The problem in this research is the service of patients in RSUD Lawang has not been entirely done using the SIM-RS application directly. This study focuses on the implementation of the SIM-RS in Lawang District Hospital in providing health services to the community. This research standard uses COBIT 5 standard with APO 07 domain which discusses the preparation of HR in Lawang District Hospital, BAI 07 discusses readiness in obtaining new information systems (SIM-RS), and DSS 01 discusses procedural development and treatment of all forms operations, infrastructure, and facilities related to the information system used. The conclusions of this study are: (1) The level reached by the APO 07 domain is at level 1. This is due to the application of the SIM-RS in the Lawang District Hospital, which has a base practice but in the design of activities that have not been adequately monitored and evaluated and the work products that have not been applied, controlled, and maintained as appropriate. (2) The level achieved by the BAI 07 domain is at level 2. This is due to the application of the SIM-RS in Lawang District Hospital, which has a planned base of practice, is well monitored and evaluated. Its implementation is following agency needs. But related to the implementation process is still not following established standards. (3) The level achieved by the DSS 01 domain is at level 1. This is due to the application of the SIM-RS in Lawang District Hospital having a base practice. Still, in the design of activities, it has not been adequately monitored and evaluated, and the work products they have not been implemented, controlled, and maintained as should be.
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Swoboda, David M., Jung-Hoon Lee, Onyee Chan, Rami S. Komrokji, Najla Al Ali, Eric Padron, Alan F. List, Mohammad O. Hussaini, Jinming Song, and David A. Sallman. "Marrow Ring Sideroblasts Are Highly Predictive for TP53 Mutation in MDS with Excess Blasts." Blood 134, Supplement_1 (November 13, 2019): 4244. http://dx.doi.org/10.1182/blood-2019-124772.
Анотація:
Background: Myelodysplastic syndrome with ring sideroblasts (MDS-RS) is defined by the World Health Organization (WHO) as ring sideroblasts (RS) ≥15% or ≥5% with associated SF3B1 mutation and no excess blasts (EB). In MDS-RS, SF3B1 mutation defines a homogenous group with isolated erythroid dysplasia and favorable prognosis (Malcovati et al. Blood 2015). Given the separate WHO classification, patients with MDS-EB frequently are not tested for RS. SF3B1-wild type (wt) MDS with RS also has not been well characterized. Therefore, herein we characterized MDS with RS, focusing on SF3B1-wt and implications of molecular subsets. Patients and Methods: Between 2013 and 2018, 157 MDS and MDS/MPN patients with RS ≥5% and next generation sequencing performed within 6 months of diagnosis at Moffitt Cancer Center were identified with clinical variables obtained at date of diagnosis. Quantification of RS was performed in all cases by hematopathology. Baseline characteristics were compared by Fisher's exact test (categorical variables) and Mann-Whitney test (continuous variables). Survival estimates were calculated using the Kaplan-Meier method from date of diagnosis and groups were compared using log-rank test. Multivariate survival analysis performed by means of Cox proportional hazards regression. Pearson correlation coefficient was used in correlative analyses. Results: A total of 75 SF3B1-mutant (mt) and 82 SF3B1-wt cases with MDS (141) or MDS/MPN (13) and RS were identified. Median age was 71 years (38-89) with male and Caucasian predominance (62% and 94%, respectively). In the SF3B1-wt cohort, there were 77 MDS and 5 MDS/MPN patients. The MDS patients consisted of 2 MDS-SLD, 15 MDS-MLD, 3 MDS-RS-SLD, 17 MDS-RS-MLD, 24 MDS-EB1 and 16 MDS-EB2. The majority of SF3B1-wt patients (58%) were high or very high risk based on the Revised International Prognostic Scoring system (IPSS-R). Median RS% was significantly lower in SF3B1-wt compared to SF3B1-mt (18% (5-50) vs 35% (5-83) p <0.0001). TP53 was the most common mutation (54%) in the SF3B1-wt cohort (n=44; Figure 1). Additional mutations observed in >10% of the SF3B1-wt cohort were DNMT3A 18% (n=15), TET2 16% (n=13) and U2AF1 16% (n=13). Non-SF3B1 spliceosome mutations represented 27% (n=22) of the SF3B1-wt cohort. TP53-mt and non-SF3B1 spliceosome-mt were observed at significantly higher prevalence in SF3B1 wt vs mt patients (p<0.0001 and p=0.003). In univariate analysis, IPSS-R, TP53 and DNMT3A were associated with worse overall survival in SF3B1-wt patients (OS). In multivariate analysis including age, IPSS-R and BMT, only TP53 was an independent covariate for inferior survival (HR 6.3; 95% CI 2.4-16.6 p<0.0001). Given the high frequency of mutations, we then focused on TP53-mt RS patients. In the total cohort of patients with RS≥5%, 77% of MDS-EB1 and 68% of MDS-EB-2 were TP53-mt. In SF3B1 wt patients with RS≥5% and excess blasts, TP53 mutation was identified in 79% (n=19) and 81% (n=13) of MDS-EB-1 and MDS-EB-2 patients, respectively (p<0.0001 TP53-mt MDS-EB vs other). 3 patients were co-mutant for TP53 and SF3B1. Increased RS as defined as >15% vs 5-15% resulted in improved OS in the TP53-mt cohort (median OS 13.5 vs 8.6 months; HR 0.36 95% CI 0.14-0.93 p=0.034). In multivariate analysis including age, IPSS-R and BMT, the survival advantage was maintained (HR 0.35 95% CI 0.14-0.93 p=0.034). Increased RS did not significantly improve OS in any other somatic mutation. Response to hypomethylating agents was similar between TP53-mt RS >15% vs 5-15% (Complete remission (CR) 21% vs 17% p=1.0 and overall response rate (ORR) 52% vs 42% p=.72). No TP53-mt RS patients responded to lenalidomide (0/4). The proportion of patients receiving allogeneic stem cell transplant was similar between TP53-mt RS >15% vs 5-15% (14% vs 22% p=0.69). There was no difference in distribution of TP53-mt between 5-15% RS cohort vs >15% (55% n=26 vs 51% n=18 p=0.82). Finally, TP53 VAF did not correlate with RS percentage (p=.393) Conclusions: In our study, MDS-RS-EB was highly concordant with the presence of TP53 mutation occurring in 80% of SF3B1-wt patients. In TP53 mutant patients, increased ring sideroblast % was an independent covariate associated with a significant survival advantage. As therapy targeting TP53 emerges, the ability to rapidly predict TP53 mutation status based on presence of ring sideroblasts should be a priority. Figure Disclosures Komrokji: Agios: Consultancy; celgene: Consultancy; pfizer: Consultancy; DSI: Consultancy; JAZZ: Consultancy; Incyte: Consultancy; Novartis: Speakers Bureau; JAZZ: Speakers Bureau. List:Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding. Sallman:Abbvie: Speakers Bureau; Novartis: Speakers Bureau; Jazz: Research Funding; Incyte: Speakers Bureau; Celyad: Membership on an entity's Board of Directors or advisory committees; Celgene: Research Funding, Speakers Bureau.
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Chvál, Martin, and Petr Urbánek. "Klima učitelského sboru: úprava dotazníku OCDQ-RS pro podmínky českých škol." Pedagogická orientace 24, no. 5 (December 15, 2014): 778–803. http://dx.doi.org/10.5817/pedor2014-5-778.
Анотація:
Cílem metodologické studie je představení psychometrických vlastností dotazníku KUS, a to i v porovnání s vlastnostmi originální verze OCDQ-RS a jeho slovenskou adaptací. V úvodní teoretické části je představen dotazník organizačního klimatu škol OCDQ-RS, jeho vznik a slovenská standardizace. Po upřesnění cíle studie následuje představení vzniku a výsledné verze dotazníku KUS, který je úpravou OCDQ-RS. Protože jsou některé výsledky porovnávány se známými psychometrickými vlastnostmi OCDQ-RS z USA, ze slovenské adaptace i nestandardizované české verze, jsou dále charakterizovány odpovídající datové soubory. Následují výsledky psychometrických analýz, diskuse zdůvodňující opuštění souhrnného indexu otevřenosti klimatu v dotazníku KUS oproti OCDQ-RS a orientační normy a odhadované chyby měření jednotlivých indexů KUSu. Po shrnujících závěrech jsou pojmenována i hlavní omezení studie. Výzkumný vzorek tvořilo 1823 učitelů ze 77 převážně základních škol. Návratnost dotazníků za školu byla minimálně 70 %. Data byla analyzována položkovou analýzou podle klasické teorie testů, exploratorní faktorovou analýzou, doplňkově i konfirmatorní faktorovou analýzou. Vnitřní konsistence indexů byla zjišťována pomocí Cronbachova alfa, ANOVA a standardní chyby měření indexů KUSu. Některé analýzy jsou s jednotkou učitel i škola. U dotazníku KUS byly zachovány čtyři indexy: podpora sboru vedením školy, angažovanost učitelů, frustrace učitelů, přátelské vztahy ve sboru. Pátý index direktivity ředitele byl nahrazen konotativně neutrálním pevnost vedení školy. Všechny indexy vykazují dostatečné hodnoty Cronbachova alfa v rozpětí od 0,84 do 0,96. Počet položek byl oproti OCDQ-RS navýšen z 34 na 40.
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Zeng, Huawei, Bryan Safratowich, Zhenhua Liu, and Michael Bukowski. "Intake of Resistant Starch Reduces Colonic Inflammation in the Colon of Obese, C57BL/6 Mice Fed a High Fat Diet." Current Developments in Nutrition 6, Supplement_1 (June 2022): 1094. http://dx.doi.org/10.1093/cdn/nzac070.053.
Анотація:
Abstract Objectives Intake of fiber has beneficial effects for gut health which may be due to short chain fatty acid (e.g., butyrate) production during colonic fermentation. In contrast, obesity and obesogenic diets are linked to increased colonic inflammation. We tested the hypothesis that increasing fiber intake reduces colonic inflammation in C57BL/6 mice fed an obesogenic diet. Methods Four-week-old male C57BL/6 mice were assigned to 5 dietary groups (n = 22/group) for 24 weeks: (1) AIN93G as a control diet (AIN); (2) a high fat diet (HFD, 45% energy fat); (3) HFD + 5% resistant starch from corn (RS); (4) HFD + 10%RS; or (5) HFD + 20%RS. We used biochemical, gas chromatography with flame-ionization detection, and histological approaches to determine the effect of RS on the inflammatory status in the colon of C57BL/6 mice fed HFD. Results All animals receiving HFD exhibited increases in body mass and body fat composition compared to the AIN group irrespective of RS dosage. However, the HFD + RS groups exhibited an increase in fecal butyrate content in a RS dose-dependent manner over the HFD group with 2.1- and 3.3-fold increase in the HFD + 10%RS and HFD + 20%RS groups, respectively. Consistent with butyrate's beneficial effects, there were concomitant > 0.5-fold decreases in inflammatory cell infiltration and b-catenin protein staining in the colon of animals receiving 20% RS supplementation relative to the HFD group. Conclusions These data indicate that even under obesogenic conditions in a mouse model, RS consumption reduces colonic inflammation. Funding Sources This work was supported by U.S. Department of Agriculture, Agricultural Research Service, research project 3062-51,000-056-00D.
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Mullinax, John, Danielle Carr, Nora Vera, Weihong Sun, M. Catherine Lee, Susan Hoover, William J. Fulp, Geza Acs, and Christine Laronga. "Distant recurrence risk with prospective use of the 21-gene assay at a single institution." Journal of Clinical Oncology 33, no. 28_suppl (October 1, 2015): 131. http://dx.doi.org/10.1200/jco.2015.33.28_suppl.131.
Анотація:
131 Background: Distant recurrence (DR) is the cause of most breast cancer deaths. The 21-gene assay (ODX) Recurrence Score (RS) result predicts both 5 and 10-yr DR risk and can guide adjuvant chemotherapy (CT) recommendations to mitigate this risk. This study analyzed the use of the RS result to guide adjuvant treatment decisions in a large single-institution, prospective cohort of patients (pts). Methods: This is an IRB-approved review of a prospective database of pts receiving ODX on an initial primary breast cancer. Data collected included demographics, primary operation, margin status, receptor status, RS, adjuvant treatment, recurrence, and survival. Pts were stratified as low risk (RS < 18), intermediate risk, or high risk (RS > 30). The primary analysis computed Kaplan-Meier estimates for rate of DR at 5 yrs when pts were stratified by RS. Results: From 2003 to 2009, a RS result was obtained on 606 pts. Median follow up was 2.9 yrs (0.1-9.7) and median age was 58 yrs (27-84). Median RS result was 16 (0-63); 344(57%) pts were low, 212(35%) intermediate, 50(8%) high. Endocrine therapy was given to 92.4%, 94.3%, and 87.5% low, intermediate, and high risk pts, respectively. Adjuvant CT was given to 8.6%, 47.6%, and 70.8% low, intermediate, and high risk pts, respectively. There were 8 DR events with 1.8% 5-yr estimated risk of DR. The 5-yr estimated risk of DR was 0.7% for low risk (344) pts, 3.4% for intermediate risk (211) pts, and 2.6% for high risk (50) pts. Among node negative [N(-)] pts (502), the 5-yr estimated risk of DR was 0.8% for low risk (287) pts, 3.7% for intermediate risk (174) pts, and 3.3% for high risk (41) pts. Among node positive [(N+)] pts (54) there was only 1 DR, which was in a high risk pt. Of pts with unknown nodal status (50), there were no DRs. Conclusions: The RS result is predictive of DR at 5 yrs as shown in historical datasets (Table). The use of ODX to guide adjuvant treatment recommendations in our contemporary, prospective cohort resulted in a much lower 5-year DR rate and thus supports its use to guide adjuvant treatment decisions. [Table: see text]
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Goudez, Raphaël, Mickael Weber, Vincent Biourge, and Patrick Nguyen. "Influence of different levels and sources of resistant starch on faecal quality of dogs of various body sizes." British Journal of Nutrition 106, S1 (October 12, 2011): S211—S215. http://dx.doi.org/10.1017/s0007114511003345.
Анотація:
In dry-extruded canine diets, starch ileal digestibility varies with the starch source, amount and processing parameters. Starch that escapes duodeno-ileal digestion can affect faecal quality by stimulating colonic bacterial fermentation. The aim of the present study was to assess the effect of various resistant starch (RS) sources and levels on the faecal score of dogs of different breeds and sizes. A total of twenty-one healthy adult female dogs (body weight ranging 5·0–30·6 kg) were used. The maintenance diet for the dogs was supplemented with increasing amounts of RS from two sources: high-amylose starch from maize (to 2·5, 4·3 and 7·4 % RS) and raw potato starch (to 7·4 and 11·4 % RS). Each level of RS was tested over a 7 d period followed by a 7 d washout period. Faecal scores were evaluated by one person using a scale ranging from 1 (for hard and dry faeces) to 5 (for liquid stools). Faeces were considered ‘optimal’ at scores of 2·5–3·0, ‘acceptable’ at scores of 3·0–3·75 and ‘unacceptable’ at scores >3·75. Small dogs showed very little sensitivity to RS based on the faecal score, while large dogs were quite responsive to RS supplementation. These results suggest that small dogs are poor models for assessing the effect of starch sources on ileal digestibility. They also indicate that a low RS content (strongly affected by source and processing) is an important factor for ensuring an optimal faecal score in large breed dogs.
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Cevenini, R., M. Donati, S. Bertini, A. Moroni, and V. Sambri. "Capture-ELISA for serum IgM antibody to respiratory syncytial virus." Journal of Hygiene 97, no. 3 (December 1986): 511–17. http://dx.doi.org/10.1017/s0022172400063713.
Анотація:
SUMMARYA four-component solid-phase capture enzyme immunoassay was set up to test for serum IgM antibody to respiratory syncytial (RS) virus and was compared with immunofluorescence assay (IFA).A total of 128 young children with acute respiratory infections were studied. Thirty-six were shown to be RS virus-positive by the detection of RS virus in nasopharyngeal secretions and 92 were RS virus-negative. A serum specimen was collected after admission to the hospital (days 0–4) and a further specimen was obtained during days 10–14. Out of 36 RS virus-positive patients, 28 (77·7%) were found to be positive for IgM by both capture-ELISA and IFA. Out of 92 RS virus-negative patients 5 (5·4%) were IgM-positive. Four false-positive results were obtained by IFA due to the presence of rheumatoid factor.The capture-ELISA was shown to be a reliable technique in detecting specific IgM antibody to RS virus.
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Плохіх, Віктор Володимирович. "Зв’язок копінг-поведінки з переживаннями плину часу у студентів". Insight: the psychological dimensions of society, № 9 (5 травня 2023): 72–93. http://dx.doi.org/10.32999/ksu2663-970x/2023-9-5.
Анотація:
Сучасний студент усупереч суттєвому підвищеннюнавчального навантаження та загальному ускладненню життєдіяльності повинен бути здатним додолання стресових ситуацій і своєчасного виконання завдань. Метою дослідження є емпіричневизначення підґрунтя та особливостей для характерних зв’язків виборів варіантів копінг-поведінкиз переживаннями плину часу у студентів. Методи.Досліджуваними були 139 студентів університету.В емпіричному дослідженні використовувалисятакі стандартизовані тестові методики: “Копінг-поведінка в стресових ситуаціях”; шкала “Компетентність у часі” з тесту самоактуалізації особистості;“Шкала переживання часу”; Фрайбургський особистісний опитувальник (форма В). Для статистичної обробки даних застосовано кластернийаналіз, кореляційний аналіз за Спірменом, U-критерій Манна-Уїтні. Результати. Компетентністьу часі в групі пов’язана з переживаннями плинучасу як швидкого (rs=-.188; p=.027), обмеженого(rs=-.265; p=.002), і на рівні тенденції – як цільного(rs=.143; p=.093) і різноманітного (rs=.157; p=.064).З використанням кластерного аналізу в групі було виділено підгрупу 1 (n=64) і підгрупу 2 (n=75).Встановлено переваги підгрупи 1 над підгрупою2 за показниками компетентності у часі (U=172.00;p<.001) та врівноваженості (U=708.00; p<.001).У підгрупі 1 досліджувані порівняно більше орієнтовані на копінги уникнення (U=1811.00; p=.013)та відволікання (U=1861.00; p=.022), а в підгрупі 2 –на емоційне реагування в стресі (U=1120.00;p<.001). Було встановлено, що в досліджуваних підгрупи 2 порівняно сильніші переживання часу якобмеженого (U=1762.00; p=.006) і як роздробленого(U=1983.50; p=.073). У групі копінг, орієнтованийна вирішення завдання, корелює з переживаннямиплину часу як швидкого (rs=.183; p=.031), наповненого (rs=.361; p<.001), приємного (rs=.182; p=.032),різноманітного (rs=.175; p=.040), організованого(rs=.296; p<.001); копінг, орієнтований на емоції,корелює з переживаннями плину часу як швидкого (rs=.208; p=.014), стрибкоподібного (rs=.256;p=.002), роздробленого (rs=.222; p=.009), обмеженого (rs=.182; p=.032). Висновки. Повноціннепозитивне переживання досліджуваними моментутеперішнього (як цільного, безмежного, повільноплинного) пов’язане з наданням переваги свідомокерованим, прийнятним у стресовій ситуації варіантам копінг-поведінки. Емоційно зорієнтованакопінг-поведінка студентів прямо корелює з проблемними особливостями особистості та з переживаннями фрагментації, розпаду плину часу. Застосування студентами копінгу, орієнтованого навирішення завдань у стресових ситуаціях, обмежується недостатньою цілісністю особистого досвіду,що формується, пов’язане з переживаннями плинучасу як наповненого, приємного, різноманітного,організованого, але й швидкоплинного.
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Nair, Sandeep V., Thazhath Mavali Ramachandran, Prajob Prasad Geevarghese, N. Sunil Kumar, and Shine J. Pakalomattom. "Rigid Sigmoidoscopic Examination, an Investigation Down but Not Out: A 5-Year Single-Center Experience on 9418 Patients." Journal of Digestive Endoscopy 10, no. 01 (January 2019): 044–48. http://dx.doi.org/10.4103/jde.jde_55_18.
Анотація:
ABSTRACT Background: Rigid sigmoidoscopy (RS) in the present era of flexible sigmoidoscopies is falling out of favor although it continues to be used in some centers as an outpatient (OP) department procedure. Aims: This study aims to determine the utility of RS for diagnosis of rectosigmoidal pathologies in the OP setting with emphasis on neoplastic lesions. Methods: We retrospectively studied the RS records and histopathology reports (HPRs) of 5 years (July 2013–June 2018) done in the Department of Gastroenterology at Medical College Calicut. Results: During the study period, 9418 RS examinations were done, and a total of 6921 abnormalities were picked up, giving a diagnostic yield of 73.5%. Most common indication was bleeding per rectum (PR) (51%), followed by constipation (29%). The most common lesion found was hemorrhoids 39.8% followed by proctitis 13.7%, neoplasms 9.7%, and others 10.3% while 26.5% studies were normal. HPRs showed 7.7% to be malignant, 5.8% were adenoma, 12.2% were inflammatory bowel disease ulcerative colitis (IBD UC), 2.2% were solitary rectal ulcer syndrome, 1.2% nonspecific colitis, 1.7% nonneoplastic polyps, 2.7% were normal, and 1.4% were inconclusive. Of the 4812 patients with complaints of bleeding PR, 4739 (98.5%) had a diagnosis after RS, of which hemorrhoids (72.7%) was the most common cause followed by proctitis (14.2%), neoplasm (9%), and others (4.1%). The sensitivity, specificity, positive predictive value, and negative predictive value of RS in detecting neoplasia was 98.2%, 96.8%, 66.1%, and 99.9%, respectively, when HPR was gold standard. RS was found to be effective for assessing activity in IBD UC. Conclusion: RS is a simple, cheap, and effective tool for diagnosing various rectosigmoid pathologies. RS can be used as an effective screening test for rectosigmoid pathologies, especially neoplasia and IBD UC.
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Gupta, J. K., Krishna Avatar Meena, and M. L. Meena. "Comparative Economics of Different Management Tactics by Novel Insecticides against Pest Complex on Capsicum (Capsicum annuum L.) under Protected Conditions." Environment and Ecology 42, no. 2A (May 2024): 732–37. http://dx.doi.org/10.60151/envec/tglm7980.
Анотація:
Field experiment was conducted under shade net house at Hi-Tech Horticulture Farm, Rajasthan Agricultural Research Institute, Durgapura (Sri Karan Narendra Agriculture University, Jobner), Jaipur, Rajasthan to work out the economics and cost benefit ratio of different management strategies by three spraying of eleven bio-rationale and newer pesticides against Yellow Mite, Polyphagotarsonemus latus (Banks), thrips, Scirtothrips dorsalis Hood, aphids (Aphis gossypii Glover, Myzus persicae Sulzer), Whitefly, Bemisia tabaci (Gennadius) and Beat army worm, Spodoptera exigua (Hubner) during summer 2014 and 2015 on capsicum (Capsicum annuum L.). The result on the basis of pooled data indicated that maximum net profit of Rs 77185/ha was obtained in the treatment of fipronil 0.005% with the yield of 51.46 q/ha followed by emamectin benzoate 0.002% (Rs 67422/ha) with the yield of 49.77 q/ha. The minimum net profit of Rs 23840/ha was recorded in the treatment of NSKE 5% followed by azadirachtin 0.0003% (Rs 29876). The net profit ranging from Rs 53613/ha to Rs 60263/ha was computed in the treatment of acephate (Rs 53613/ha), spiromesifen (Rs 59971/ha), spinosad (Rs 58262/ha) and indoxacarb (Rs 60263/ha), whereas, Rs 39125/ha to 41476/ha was found in propargite and novaluron. The maximum incremental cost benefit ratio (1:20.23) was found in fipronil (0.005%) followed by 1:17.99 in the treatment of acephate (0.075%). The minimum ICBR (1:4.64) was recorded in the treatments of novaluron followed by spinosad (1:5.96). Study revealed that three spray of fipronil 5 SC @ 1 ml/l or emamectin benzoate 5 SG @ 0.4 g/l can be suggested to the farmers for the management of pest complex on capsicum under shade net house conditions during summer for off season production.
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Konca, Yusuf, Mahmut Kaliber, Hasan Huseyin Uzkulekci, Behzat Cimen, and Hasan Yalcin. "The Effect of Rosehip (Rosa canina L.) Supplementation to Diet on the Performance, Egg and Meat Quality, Antioxidant Activity in Laying Quail." Sains Malaysiana 50, no. 12 (December 31, 2021): 3617–29. http://dx.doi.org/10.17576/jsm-2021-5012-13.
Анотація:
This study was conducted to determine the effects of rosehip (RS, Rosa canina L.) supplementation on the performance, carcass traits, meat quality, serum antioxidant activity, egg yolk pigmentation and fatty acid composition of laying quail. A total of 120 10-week-old laying quail were divided into 5 treatment groups with 8 replicates. The treatments were as follows: the first group was fed control diet (C, no rosehip addition), other groups (2, 3, 4 and 5) were fed with diets containing 2.5, 5, 10 and 15% RS, respectively. The body weight (BW), feed consumption (FC) and egg yield were not affected by the treatments. However, egg weight and egg mass increased with 5 and 10% RS supplementation (P<0.01). The breast meat’s dry matter, crude protein, ash, fat, drip loss, thawing loss, cooking loss, postmortem pH1 values and the colour were not statistically influenced by RS supplementation. Rosehip supplementation caused a decrease in the L* values of egg yolk colour, however, the redness (a*) and yellowness (b*) values of the egg yolk was higher than that of the C group (P<0.01). Rosehip supplementation did not change the fatty acid composition of egg yolk. Rosehip addition at 2.5 and 5% ratio to diets decreased serum malondialdehyde (MDA), and increased serum superoxide dismutase (SOD) levels (P<0.01); while addition of 10 and 15% RS caused an increase in serum MDA and decrease in serum SOD levels compared to C group (P<0.01). In conclusion, rosehip as a feed ingredient in quail diets can be used to increase egg weight, egg mass and egg yolk pigmentation and low (2.5 and 5%) RS supplementation may decrease serum oxidant activity but not high concentrations (10 and 15%) of RS.
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Younes, Hassan, Christian Demigné, and Christian Rémésy. "Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rat." British Journal of Nutrition 75, no. 2 (February 1996): 301–14. http://dx.doi.org/10.1017/bjn19960132.
Анотація:
AbstractThe effect of fermentation on colonic absorption of Ca and Mg was investigated in 8-week-old rats adapted to diets containing either digestible wheat starch (DS diets) or including resistant starch, i.e. 350 g raw potato starch/kg (RS diets). The dietary Ca level of the DS and RS diets was 2·5 or 7·5 g/kg. RS diets resulted in enlargements of the caecum together with hypertrophy of the caecal wall. Acidification of the caecal contents by mictobial fermentation of RS was influenced by the dietary Ca level. Very acidic pH conditions and relatively low concentrations of short-chain fatty acids, in the presence of lactic acid fermentation, were observed with the 2·5 g Ca/kg level. Rats fed on RS diets had a bhigher pencentage of soluble Ca (and inorganic phosphate) in the caecum, particularly of rats adapted to the high Ca level. As a result of the hypertrophy of the caecal wall and of an elevated concentration of soluble Cas, the caecal absorption of Ca was 5-6 fold higher in the RS groups than in the DS groups. The difference between dietary intakle and faecal excretion (DI-FE) of Ca was higher in rats fed on RS diets than in those fed on DS diets, when the dietary Ca level was 2·5 g/kg. With the higher Ca intake the elevated rate of Ca absorption from the caecum in RS-fed rats was not paralleled by an enhanced DI-EE difference: this suggests a shift of the Ca absorption towards the large intestine. Feeding Rs diets also enhanced Mg caecal absorption, resulting in the substatntially higher DI-FE difference for Mg, especially with the 2·5 g Ca/kg diets, because a high Ca intake tends to inhibit Mg absorption. The present findings support the view that the large intestine may represent a major site of Ca (and Mg) absorption when acidic fermentations take place. This process could improve the digestive Ca balance when the dietary Ca supply is low; when the Ca supply is affluent, it rather shits Ca absorption towards a more distal site fo the digestive tract.
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Dewilda, Yommi, and Firsti Listya Darfyolanda. "Pengaruh Komposisi Bahan Baku Kompos (Sampah Organik Pasar, Ampas Tahu, dan Rumen Sapi) terhadap Kualitas dan Kuantitas Kompos." Jurnal Dampak 14, no. 1 (January 10, 2017): 52. http://dx.doi.org/10.25077/dampak.14.1.52-61.2017.
Анотація:
This research combines market waste (SP), Soybeanwaste and the cow's rumen (RS) as raw material for composting. Composter consists of eight variations, variations 1 (60% SP; 40% AT; 0% RS), variation of 2 (60% SP; 20% AT; 20% RS), variation 3 (50% SP; 30% AT; 20 % RS), variations in 4 (40% SP; 40% AT; 20% RS), variations in 5 (70% SP; 10% AT; 20% S), variations in 6 (60% SP; 30% AT; 10% RS ), variations in 7 (50% SP; 40% AT; 10% RS), variations of 8 (60% SP; 20% AT; 20% RS; EM4). This study aimed to analyze the effect of variations composition of the compost raw materials in order to obtain a variation of the most optimum for composting. The methods used are composting semiaerob. The observation of the maturity of the compost to the parameters of temperature, pH and color meets the standards of SNI 19-7030-2004 with composting 16-33 days old. The results of the analysis of all variations of the water content of the compost quality, C-organic, nitrogen, C / N ratio, phosfor, and potassium, has met the standard of SNI 19-7030-2004. Of the total raw material compost as much as 3 liters, obtained quantity of solid compost and liquid compost from 0.45 to 0.87 liters of 0.45 to 1.2 liters. Based on the scoring result of the maturity, quality, and quantity of compost, obtained the best variation is a variation 5.Keywords : Soybean waste,kompos quality and quantity, cow's rumen, market wasteAbstrak-Penelitian ini mengkombinasikan sampah pasar (SP), ampas tahu (AT) dan rumen sapi (RS) sebagai bahan baku pengomposan. Tujuan penelitian untuk menganalisis pengaruh variasi komposisi bahan baku kompos sehingga diperoleh variasi yang optimum untuk proses pengomposan. Komposter terdiri dari 8 variasi yaitu variasi 1(60% SP; 40% AT; 0% RS), variasi 2 (60% SP; 20% AT; 20% RS), variasi 3 (50% SP; 30% AT; 20% RS), variasi 4 (40% SP; 40% AT; 20% RS), variasi 5 (70% SP; 10% AT; 20% S), variasi 6 (60% SP; 30% AT; 10% RS), variasi 7(50% SP; 40% AT; 10% RS), variasi 8 (60% SP; 20% AT; 20% RS; EM4). Metoda yang digunakan adalah pengomposan semiaerob. Hasil pengamatan terhadap kematangan kompos untuk parameter temperatur, pH, warna telah memenuhi standar SNI 19-7030-2004 dengan lama pengomposan 16-33 hari. Hasil analisis semua variasi kualitas kompos yaitu kadar air, C-organik, nitrogen, rasio C/N, phosfor, dan kalium, telah memenuhi standar SNI 19-7030-2004. Dari total bahan baku kompos sebanyak 3 liter, didapatkan kuantitas hasil kompos padat 0,45-0,87 liter dan kompos cair 0,45-1,2 liter. Berdasarkan hasil skoring terhadap kematangan, kualitas, dan kuantitas kompos, didapatkan variasi terbaik adalah variasi 5 (70% SP; 10% AT; 20% RS).Kata Kunci : Ampas tahu, kualitas kompos, kuantitas kompos, rumen sapi, sampah pasar
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Rees, Joanna, Simone Radavelli Bagatini, Johnny Lo, Jonathan M. Hodgson, Claus T. Christophersen, Robin M. Daly, Dianna J. Magliano, et al. "Association between Fruit and Vegetable Intakes and Mental Health in the Australian Diabetes Obesity and Lifestyle Cohort." Nutrients 13, no. 5 (April 24, 2021): 1447. http://dx.doi.org/10.3390/nu13051447.
Анотація:
Increasing prevalence of mental health disorders within the Australian population is a serious public health issue. Adequate intake of fruits and vegetables (FV), dietary fibre (DF) and resistant starch (RS) is associated with better mental and physical health. Few longitudinal studies exist exploring the temporal relationship. Using a validated food frequency questionnaire, we examined baseline FV intakes of 5845 Australian adults from the AusDiab study and estimated food group-derived DF and RS using data from the literature. Perceived mental health was assessed at baseline and 5 year follow up using SF-36 mental component summary scores (MCS). We conducted baseline cross-sectional analysis and prospective analysis of baseline dietary intake with perceived mental health at 5 years. Higher baseline FV and FV-derived DF and RS intakes were associated with better 5 year MCS (p < 0.001). A higher FV intake (754 g/d vs. 251 g/d, Q4 vs. Q1) at baseline had 41% lower odds (OR = 0.59: 95% CI 0.46–0.75) of MCS below population average (<47) at 5 year follow up. Findings were similar for FV-derived DF and RS. An inverse association was observed with discretionary food-derived DF and RS. This demonstrates the association between higher intakes of FV and FV-derived DF and RS with better 5 year mental health outcomes. Further RCTs are necessary to understand mechanisms that underlie this association including elucidation of causal effects.
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Pratiwi, Wiwit Sri Werdi, Anil Kumar Anal, and Surya Rosa Putra. "Production by Lintnerization-Autoclaving and Physicochemical Characterization of Resistant Starch III from Sago Palm (Metroxylon sagu rottb)." Indonesian Journal of Chemistry 15, no. 3 (November 12, 2015): 295–304. http://dx.doi.org/10.22146/ijc.21199.
Анотація:
Indonesia is one of the biggest central distributions of sago starch. There are some characteristics of sago starch which make it difficult to use in variation of foods. In this study, resistant starch type III (RS3) was produced from sago starch by using lintnerization-autoclaving (LA). Physicochemical characterizations of RS3 were compared by native sago starch (NA), hydrolyzed starch by distilled water (DW) and lintnerized starch (L). Amylose content decreased after hydrolyzed by DW and L, but increasing by using LA. Protein and fat contents decreased after hydrolysis, but crude fiber content increasing, the highest value was obtained lintnerized-autoclaved starch. Lintnerized-autoclaved starch has more compact and rigid structure. The RVA viscosity, swelling power and water holding capacity values reduced after all treatments. Oil in water emulsions were also analyzed by mixture of RS3 and emulsifier (casein or SPI). Viscosities of emulsions from RS casein were lower than those of RS-SPI. Emulsion capacity and emulsion stability values were better gotten using RS-SPI than RS-casein. The highest of emulsion capacity was obtained 11.33%. For storage period, the lowest peroxide and anisidine values of mixture RS-emulsifier were resulted from 5% emulsifier + 5% RS + 5% fish oil.
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Goto, Shiro, Koji Nishida, and Yasuhiro Shimoda. "Topics on symbolic Rees algebras for space monomial curves." Nagoya Mathematical Journal 124 (December 1991): 99–132. http://dx.doi.org/10.1017/s0027763000003792.
Анотація:
Let A be a regular local ring of dim A = 3 and p a prime ideal in A of dim A/p = 1. We put Rs(p) = (here t denotes an indeterminate over A) and call it the symbolic Rees algebra of p. With this notation the authors [5, 6] investigated the condition under which the A-algebra Rs(p) is Cohen-Macaulay and gave a criterion for Rs(p) to be a Gorenstein ring in terms of the elements f and g in Huneke’s condition [11, Theorem 3.1] of Rs(p) being Noetherian. They furthermore explored the prime ideals p = p(n1, n2, n3) in the formal power series ring A = k[X, Y, Z] over a field k defining space monomial curves and Z = with GCD(n1, n2, nz) = 1 and proved that Rs(p) are Gorenstein rings for certain prime ideals p = p(n1 n2, n3). In the present research, similarly as in [5, 6], we are interested in the ring-theoretic properties of Rs(p) mainly for p = p(n1 n2) nz) and the results of [5, 6] will play key roles in this paper.
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Peng, Shuyi, Yihao Guo, Xiaoyong Zhang, Juan Tao, Jie Liu, Wenying Zhu, Leqing Chen, and Fan Yang. "High-Resolution DWI with Simultaneous Multi-Slice Readout-Segmented Echo Planar Imaging for the Evaluation of Malignant and Benign Breast Lesions." Diagnostics 11, no. 12 (December 4, 2021): 2273. http://dx.doi.org/10.3390/diagnostics11122273.
Анотація:
To investigate the feasibility and effectiveness of high-resolution readout-segmented echo planar imaging (rs-EPI), diffusion-weighted imaging (DWI) is used simultaneously with multi-slice (SMS) imaging (SMS rs-EPI) for the differentiation of breast malignant and benign lesions in comparison to conventional rs-EPI on a 3T MR scanner. A total of 102 patients with 113 breast lesions underwent bilateral breast MRI using a prototype SMS rs-EPI sequence and a conventional rs-EPI sequence. Subjective image quality was assessed using a 5-point Likert scale (1 = poor, 5 = excellent). Signal-to-noise ratio (SNR), lesion contrast-to-noise ratio (CNR) and apparent diffusion coefficients (ADC) value of the lesion were measured for comparison. Receiver operating characteristic curve analysis was performed to evaluate the diagnosis performance of ADC, and the corresponding area under curve (AUC) was calculated. The image quality scores in anatomic distortion, lesion conspicuity, sharpness of anatomical details and overall image quality of SMS rs-EPI were significantly higher than those of conventional rs-EPI. CNR was enhanced in the high-resolution SMS rs-EPI acquisition (6.48 ± 1.71 vs. 4.23 ± 1.49; p < 0.001). The mean ADC value was comparable in SMS rs-EPI and conventional rs-EPI (benign 1.45 × 10−3 vs. 1.43 × 10−3 mm2/s, p = 0.702; malignant 0.91 × 10−3 vs. 0.89 × 10−3 mm2/s, p = 0.076). The AUC was 0.957 in SMS rs-EPI and 0.983 in conventional rs-EPI. SMS rs-EPI technique allows for higher spatial resolution and slight reduction of scan time in comparison to conventional rs-EPI, which has potential for better differentiation between malignant and benign lesions of the breast.
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Gupta, A. K., and S. S. Rao. "EFFICACY OF NEEM-BASED FORMULATIONS AGAINST BUD FLY DASYNEURA LINI BARNES ON INSEED LINUM USITATISSIMUM L." Journal of Biopesticides 6, no. 1 (June 1, 2013): 37–40. http://dx.doi.org/10.57182/jbiopestic.6.1.37-40.
Анотація:
ABSTRACT An experiment was conducted during 2007-2008 and 2009-2010 to evaluate the efficacy of neem- based formulation against linseed bud fly, Dasyneura lini Barnes for three consecutive rabi seasons. Bud fly incidence was found low in Neem Seed Kernel Extract (NSKE) @ 5% than by Neem Seed Extract (NSE) @ 5%. Mean grain yield was high in NSKE@ 5% treated crop with (1287.20 kg/ha) than NSE@ 5% (1271.74 kg/ha). The higher seed yield in treated plots might have been obtained due to reduced incidence of the pest. Maximum net profit was gained from the plot treated with NSKE @ 5% (Rs. 9150.33) followed by NSE @ % 5 (Rs. 8763.75) and Nimbolin @ 0.5% (Rs. 6690.25). Similarly, Incremental Cost Benefit Ratio (ICBR) earned highest with NSKE @ 5% (16.34) closely followed by NSE@ 5% (15.65) and Nimbolin @ 0.5% (13.94).
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Patnaik, Mrinal M., Curtis A. Hanson, Nanna Sulai, Janice M. Hodnefield, Ryan A. Knudson, Rhett P. Ketterling, Terra L. Lasho, and Ayalew Tefferi. "Prognostic Irrelevance of Ring Sideroblast Percentage in World Health Organization Defined Myelodysplastic Syndromes without Excess Blasts,." Blood 118, no. 21 (November 18, 2011): 3803. http://dx.doi.org/10.1182/blood.v118.21.3803.3803.
Анотація:
Abstract Abstract 3803 Background: Ring sideroblasts (RS) represent abnormal mitochondrial iron deposits that are commonly present in myelodysplastic syndromes (MDS). The presence of ≥15% RS, by definition (World Health Organization-WHO) is necessary for a diagnosis of a MDS-RS; with refractory anemia with ring sideroblasts (RARS) being a specific morphologic category. RS can also be seen with other morphologic categories such as; refractory cytopenias with multilineage dysplasia (RCMD), MDS-unclassifiable (MDS-U) and refractory anemia with excess blasts (RAEB-1/2). Amongst these categories, RARS is generally believed to have the best survival rate with the lowest risk of leukemic transformation and this has been attributed to the absence of associated dysplasia in more than one lineage. However, it has not been systematically shown whether or not the exact percentage of RS provides additional prognostic information in the context of an accurate morphologic categorization and risk stratification by karyotype or the revised IPSS (IPSS-R). Methods: 200 patients with primary MDS without excess blasts and ≥1% RS were seen at the Mayo Clinic from 1997 through 2007. All patients underwent bone marrow (BM) examination and cytogenetic evaluation at diagnosis and the pathology slides, including iron stains, were centrally re-reviewed to accurately quantify bone marrow (BM) RS percentage and to confirm WHO morphologic categories. Molecular profiling included analysis for IDH1, IDH2, JAK2 and MPL mutations. For the purposes of this study patients were divided into 4 categories based on the RS percentage; <5%, 5–14%, 15–50% and >50%. In addition, each patient was assigned IPSS and IPSS-R prognostic scores at diagnosis and risk stratified by karyotype according to the IPSS-R cytogenetic risk categories. Cox proportional regression method was used for multivariable analysis. Results: Of the overall 200 study patients, 140 (70%) were male and median age was 71 years (range, 17–90 years). At presentation, 34 (17%) patients were red cell transfusion-dependent. There were 56 (28%) patients with <5% RS (RCMD-52, MDS-U-14), 32 (16%) with 5–14% RS (RCMD-29, MDS-U-3), 79 (39%) with 15–50% RS (RARS-43, RCMD-29, MDS-U-2) and 33 (16%) with >50% RS (RARS-13, RCMD-17, MDS-U-3). Three patients (2%) were IDH1 mutant (RARS-1, RCMD-2), 17 (8%) IDH2 mutant (RARS-1, RCMD-14, MDS-U-2), 5 JAK2 V617F (3%) mutant (RARS-2, RCMD-3) and one patient with RCMD had the MPL W515L mutation. At a median follow-up of 33 months, 156 (73%) deaths and 24 (12%) leukemic transformations were documented. Median survivals were 63 months for MDS with >50% RS, 43 months for MDS with 15–50% RS, 35 months for MDS with 5–14% RS, and 14 months for MDS with <5% RS (p=0.005). In univariate analysis, additional risk factors included decreased hemoglobin, decreased platelet count, increased circulating blasts, WHO morphologic categories, red cell transfusion need, IPSS, IPSS-R and cytogenetic risk categories per IPSS-R. On a multivariable analysis only the IPSS-R prognostic score (p<0.0001) and the WHO morphologic categories (p=0.02 for RARS) retained significance. Univariate analysis disclosed significantly inferior leukemia-free survival (LFS) in patients with RCMD, thrombocytopenia, increased circulating blasts, and poor IPSS and IPSS-R prognostic scores. On multivariable analysis once again only the IPSS-R prognostic scores (p=0.02) and WHO morphologic categories (p=0.02) retained their significance. In other words, RS percentage, independent of WHO classification, as a continuous or categorical variable (i.e.: <5%, 5–14%, 15–50% & >50%) did not affect either overall survival or LFS. Conclusions: In MDS without excess blasts, once an accurate WHO morphologic categorization is made based on the presence or absence of multi-lineage dysplasia, there is no additional prognostic value for quantifying bone marrow ring sideroblasts. WHO classification and IPSS-R prognostic scores remain the most important factors in assessing patients with MDS. Disclosures: No relevant conflicts of interest to declare.
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Vita, Roberto, Salvatore Benvenga, Bruno Giammusso, and Sandro La Vignera. "Determinants of Early Response to Low-Intensity Extracorporeal Shockwaves for the Treatment of Vasculogenic Erectile Dysfunction: An Open-Label, Prospective Study." Journal of Clinical Medicine 8, no. 7 (July 11, 2019): 1017. http://dx.doi.org/10.3390/jcm8071017.
Анотація:
The aim of this study was to expand existing literature on the effects of cardiovascular risk factors on the outcome of low-intensity extracorporeal shockwaves therapy (LIESWT), and to evaluate the role of hormone concentrations. Twenty patients with long-standing, PDE5i-resistant, vasculogenic erectile dysfunction (VED) were treated with six weekly sessions of LIESWT (9000 pulses). After a three-week break, four poor responders underwent another six weekly sessions. Rigidity score (RS) questionnaire was administered at baseline (T0), last session (T1), and three months after LIESWT (T2), while the Improvement component of the Clinical Global Impression of Change (CGIC-I) and the International Index of Erectile Function-5 (IIEF-5) questionnaires were administered at T1 and T2, and at T0 and T2, respectively. At T0 serum luteinizing hormone (LH), testosterone, sex hormone binding globulin (SHBG), calculated free testosterone, and prolactin levels were also recorded. At T1 and T2, 12/20 (60%) and 11/20 (55%) patients reached a RS ≥ 3; 16/20 (80%) and 13/20 (65%) improved their erections variably. Testosterone levels correlated positively with CGIC-I at T1. Patients < 65 years and those nonhypercholesterolemic had higher RS at T1 and T2. Age correlated negatively with RS at T1 and T2. At T0, diabetic patients had lower IIEF-5 scores, but those with RS ≥ 3 at T1 had higher IIEF-5 compared to those with RS < 3. Also, diabetes duration correlated inversely with IIEF-5 at T0. At T2, IIEF-5 improved significantly by an average of 2.8-points. We confirm safety and effectiveness of LIESWT for the treatment of VED. Age ≥ 65 years, diabetes, and hypercholesterolemia influence early and negatively the outcome of LIESWT.
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Geradts, Joseph, Aisha Kousar, Jan Wong, Nasreen Vohra, Mahvish Muzaffar, and Anas Mohamed. "Abstract P4-06-09: Prediction of oncotype DX recurrence score by patho-biologic variables and three surrogate models." Cancer Research 82, no. 4_Supplement (February 15, 2022): P4–06–09—P4–06–09. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-06-09.
Анотація:
Abstract Background: The Oncotype DX Recurrence Score (RS) predicts recurrence and chemotherapy benefit in early stage estrogen receptor positive breast cancer patients. Cost and unavailability are two major disadvantages of the assay. Multiple models have been developed to predict the RS using different pathobiologic parameters. The goal of our study was to predict RS based on histopathologic and biomarker features, and to determine concordance and correlation with RS of three surrogate models that are independent of Ki67 index: Breast Cancer Prognostic Score (BCPS), Magee0, and Magee2. Methods: Early stage, ER-positive breast cancer cases with available RS were reviewed (n = 442). ER, PR and HER2 subscores were abstracted from the Oncotype DX reports. RS categories were stratified by pathologic and biomarker variables. Histopathologic and biomarker data were abstracted from pathology reports, and the surrogate RS was calculated by each model. Correlation and concordance between models and actual RS were calculated. Analyses were performed using both conventional (18, 30) and TAILORx (11, 25) thresholds. Results: Less than 5% of breast cancers with pure or mixed lobular features, low grade tumors, carcinomas with high PR content, or Luminal A tumors had a RS >25 (Table 1). Recurrence scores in node-positive tumors were not significantly higher compared to node-negative cases. Both actual and calculated RS were higher in Luminal B versus Luminal A breast cancers. Subscore analysis revealed 99.5% concordance for ER status, 90% concordance for PR status, and 96% concordance for HER2 status (Table 2). BCPS, Magee0, and Magee2 algorithms demonstrated correlation coefficients with RS of 0.63, 0.61, and 0.62, respectively. BCPS showed the best agreement with RS using conventional cutoffs (73%), whereas the two Magee algorithms showed better concordance with the TAILORx thresholds. Two-step discordances were uncommon, especially with the TAILORx cutoffs and Magee2. When a RS of 25 was used to separate high risk from non-high risk cases, concordance rates of 86-88% were achieved for all three models. Using different tumor blocks for Oncotype and biomarker testing did not adversely affect correlation or concordance with RS. Discussion: High RS was observed only in a small percentage of pure or mixed lobular carcinomas, low grade or Luminal A tumors, and tumors with high PR expression, suggesting that these breast cancers may not require Oncotype testing. All three surrogate models demonstrated comparable correlation and high concordance with the RS when a cutoff of 25 was used, suggesting their utility in cases where the actual RS in unavailable. Our data also indicate that models using different hormone receptor quantitation methods (Allred versus H-score) have similar performance characteristics. Possible sources of discordance between actual and computed RS include methodological differences, variable tumor cellularity, intratumoral heterogeneity, and inflammatory infiltrates. Table 1.Stratification of RS Risk Categories by Pathologic and Biomarker VariablesConventional Risk CategoryLow RiskIntermediate RiskHigh RiskTAILORx Risk CategoryLow RiskIntermediate RiskHigh RiskOncotype DX Recurrence Score<1111-1718-2526-30>30n (%)n (%)n (%)n (%)n (%)Histologic Type (n)Invasive ductal carcinoma (340)94 (28)121 (36)73 (21)20 (6)32 (9)Invasive lobular carcinoma (47)10 (21)27 (57)8 (17)1 (2)1 (2)Mixed ductal/lobular carcinoma (22)3 (14)15 (68)4 (18)0 (0)0 (0)Invasive mucinous carcinoma (10)4 (40)4 (40)0 (0)1 (10)1 (10)Molecular Subtype (n)Luminal A (317)112 (35)143 (45)46 (15)11 (3)5 (1)Luminal B (125)9 (7)33 (26)41 (33)10 (8)32 (26)Combined Tumor Grade (n)Low (143)45 (31)59 (41)32 (22)4 (3)3 (2)Intermediate (239)69 (29)101 (42)41 (17)13 (5)15 (6)High (60)5 (8)17 (28)13 (22)5 (8)20 (33)ER (n)High (Allred Score 7-8) (408)120 (29)164 (40)74 (18)21 (5)29 (7)High (Modified H Score ≥ 200) (320)101 (32)133 (42)54 (17)15 (5)17 (5)Low (Allred Score 3-6) (34)1 (3)12 (35)12 (35)1 (3)8 (24)Low (Modified H Score < 200) (122)18 (15)45 (37)33 (27)7 (6)19 (16)PR (n)High (Allred Score 7-8) (306)106 (35)146 (48)41 (13)9 (3)4 (2)High (Modified H Score ≥ 200) (248)96 (39)111 (45)31 (13)8 (3)2 (1)Low (Allred Score 3-6) (97)12 (12)27 (28)32 (33)7 (7)19 (20)Low (Modified H Score 1-199) (155)23 (15)61 (39)41 (26)9 (6)21 (14)Negative (Allred Score 0-2) (39)1 (3)5 (13)14 (36)5 (13)14 (36)Negative (Modified H Score <1) (39)1 (3)5 (13)14 (36)5 (13)14 (36)HER2 (n)Negative (428)120 (28)170 (40)84 (20)20 (5)34 (8)Positive/Equivocal (14)0 (0)6 (34)3 (21)2 (14)3 (21) Table 2.Concordance Between Clinical ER, PR, and HER2 Status and Oncotype DX SubscoreOncotype DX SubscoresClinical LabNegativeBorderlinePositiveERNegative0N/A0Positive2N/A379PRNegative29N/A4Positive34N/A314HER2Negative36540Equivocal800Positive220 Citation Format: Joseph Geradts, Aisha Kousar, Jan Wong, Nasreen Vohra, Mahvish Muzaffar, Anas Mohamed. Prediction of oncotype DX recurrence score by patho-biologic variables and three surrogate models [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-06-09.
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Hidalgo Lopez, Juliana, Rashmi Kanagal-Shamanna, Bryce Macek, Adrian Carballo-Zarate, Rafael Rojas Sáurez, Steven Reyes, Chong Zhao, and Carlos E. Bueso-Ramos. "Splicing Factor Pathway Is Rarely Mutated in Myeloid Blast Phase of PV with Dysmyelopoiesis and Ring Sideroblast." Blood 132, Supplement 1 (November 29, 2018): 4309. http://dx.doi.org/10.1182/blood-2018-99-116589.
Анотація:
Abstract Introduction: BP of PV presents with dyserythropoiesis, including ring sideroblasts, and bilineage dysplasia in most cases. Clonal evolution or acquisition of new cytogenetic clone(s) plays a critical role in progression to BP of PV. SF3B1 mutation is associated with 75% of MDS with ring sideroblasts (RS). We hypothesized that an increase in ring sideroblast counts is an early event in the BP evolution. We postulate that genomic lesions other than in splicing factors genes are implicated in RS development in PV during BP evolution. Methods: We identified all cases in the last 14 years (2004 - 2018) with a diagnosis of PV in the MDACC files. We collected demographic, clinical, morphological, cytogenetic, and NGS information from 61 patients who developed BP progression from PV. We did an assessment and scoring of all bone marrow (BM) samples available at BP evolution. Results: A total of 61/477 (13%) patients with diagnosis of BP of PV were identified. Median age at BP diagnosis was 67 yrs. (32-82). This included 34 (56%) men and 27 (44%) women. At BP presentation, median BM blast percentage was 28%; 51 (84%) patients had BM dysplasia; 35 patients (69%) with dyserythropoiesis, 22 (43%) cases showed bilineage dysplasia. At BP, 43 pts had complex CG, 9 were were normal karyotype, 3 had double and 5 had single abnormalities. Prussian blue stain for Iron evaluation was available in 54 patients (89%); 24 patients (44%) had 0% RS; 19 patients (35%) had 1-14% RS; and 11 pts (20%) had >15% RS. Mutation analysis for splicing factor was performed on 13 patients. Of these, 2 patients with >15% RS had SRSF2 mutation and 1 patient with 6% RS had SF3B1 mutation. The other patients were wild type for SF3B1, SRSF2, U2AF1 (5 patients: >15% RS, 2 patients: 1-14% RS and 3 patients: 0% RS). Twenty-four (39%) patients had BM available before the BP diagnosis; median time between first BM at MDACC and BP BM diagnosis was 35 months (range, 1-135). At Baseline BM assessment, median BM blast was 3%; 13 (54%) patients had BM dysplasia. Prussian blue stain for Iron evaluation was available in 13 pts (55%): 10 pts (77%) had 0% RS and 3 pts (23%) had 1, 3, and 60% RS, respectively. To evaluate the level of RS during disease evolution we identified 10/26 pts who had at least 1 BM sample available between the first BM and the BP. 5/10 pts were in spent phase with increased blast, multilineage dysplasia and complex CG (RS: 6%, 25%, 0%, 1% and 50%) median time between samples 5 months. 4/10 pts had 1-4% blast, isolated dyserythropoiesis and normal diploid CG (RS: 12%, 5%, 2% and 0%). The median time between samples was 56 months. The last pt. had 0% blast, no dysplasia, del(20q) on CG and no RS. Pt. developed BP of PV 41 months after this follow up sample. Ten pts with PV chronic phase and were used as control group, median follow up of 14,5 yr. None of the patients had RS at baseline or at last follow up BM. Median time between samples 6 yrs. RS increase during PV evolution were statistically significant more frequent in pts who develop BP than in pts who remain in chronic phase of PV (7/10 vs. 0/10. P=0.003) Conclusion: Splicing factor gene mutation is infrequent in BP of PV despite the presence of dyserythropoiesis and frequent RS in 55% of patients. When present , RS may identify disease evolution and correlate with the disease phase of PV before BP. Dyserythropoiesis and the acquisition of RS is an early event BP of PV that precede other markers of disease progression like CG. Disclosures No relevant conflicts of interest to declare.
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S, MOHAMAD IBRAHIM, and GOPALASAMY N. "EFFECT OF AGE OF SEEDLINGS ON GROWTH AND YIELD OF TRANSPLANTED MAIZE." Madras Agricultural Journal 76, April (1989): 181–83. http://dx.doi.org/10.29321/maj.10.a02043.
Анотація:
A field experiment was conducted at the Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore to standardise the age of seedlings and to evaluate the yield potentials of transplanted crop with direct seeded ones in maize during kharil 86 and rabi 86-87. Five and ten day old seedlings raised from conventional soil nursery were compared with direct seeding. The grain yield increase with 5-day old seadlings was by 8 q/ha (14.7 per cent) and 6 q/ha (11.5 per cent) during kharif and rabi respec- tively over the direct seeded crops. There was deep decline in grain yield when 10-day old seedlings were transplanted. The highest net return of Rs. 6610 and Rs. 5503 was realised with 5-day old seedlings against Rs. 5339 and Rs. 4566 under direct seedling respectively during kharif and rabi seasons. The return per rupee invested was Rs. 2.67 and 2.39 with 5-day old seedlings as compared to 2.36 and 2.16 with direct seeding respectively for both the seasons. The method of raising nursery is also furnished.
40
Herini, E. S., I. Mangunatmadja, Purboyo S, Hardiono D. Pusponegoro, and Sunartini Sunartini. "Electroencephalogram and clinical manifestations of Rett syndrome in children." Paediatrica Indonesiana 43, no. 4 (September 24, 2016): 121. http://dx.doi.org/10.14238/pi43.4.2003.121-5.
Анотація:
Background Rett Syndrome (RS) is a severe neurodevelopmentaldisorder. Epileptic seizures occur in 80-90%; grandmal, psychomo-tor (complex partial), and focal motor seizures have been reported.The electroencephalogram(EEG) is almost always abnormal.Objective This study aimed to investigate the EEG and clinicalmanifestations of children with RSResults We investigated EEG on 5 patients with RS aged 30–66month. One patient was in clinical stage II and 4 patients in clini-cal stage III. Four patients had history of seizures, however onlytwo patients suffered from epilepsy. The EEG demonstrated slow-ing background activity in occipital region in two patients. In addi-tion, epileptic form activities were observed in 4 of 5 patients.Conclusion We concluded that epileptic spike discharge with orwithout clinical seizures were found in almost all of our RS pa-tients. These paroxysmal discharges suggested the process andthe sequences of cortical involvement. Compelling clinical, neuro-physiological evidences were very important to decide the stageof Rett disorder
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Malik, Sajid, and Peter B. Wyatt. "Preparation of (RS)-5-Amino-3-carboxypentanoic Acid (1)." Synthetic Communications 23, no. 8 (April 1993): 1047–51. http://dx.doi.org/10.1080/00397919308018580.
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Yang, Xue-Mei. "(RS)-1-[5-(2-Chloropropyl)indolin-1-yl]ethanone." Acta Crystallographica Section E Structure Reports Online 67, no. 1 (December 8, 2010): o51. http://dx.doi.org/10.1107/s1600536810050476.
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Clark, R. D., A. Jahangir, L. A. Flippin, J. A. Langston, E. Leung, D. W. Bonhaus, E. H. F. Wong, L. G. Johnson, and R. M. Eglen. "Rs-100235: A high affinity 5-HT4 receptor antagonist." Bioorganic & Medicinal Chemistry Letters 5, no. 18 (September 1995): 2119–22. http://dx.doi.org/10.1016/0960-894x(95)00358-z.
44
Knirsch, Stefan, Ulrich Weiss, Stefan Zülch, and Michael Kilger. "Electric Supercharging in the Audi RS 5 TDI Concept." MTZ worldwide 76, no. 1 (November 29, 2014): 14–19. http://dx.doi.org/10.1007/s38313-014-1001-3.
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Knirsch, Stefan, Ulrich Weiss, Stefan Zülch, and Michael Kilger. "Die elektrische Aufladung im Audi RS 5 TDI Concept." MTZ - Motortechnische Zeitschrift 76, no. 1 (December 12, 2014): 36–41. http://dx.doi.org/10.1007/s35146-014-2001-1.
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Rooke, G. Alec, Jong-Ho Choi, and Michael J. Bishop. "The Effect of Isoflurane, Halothane, Sevoflurane, and Thiopental/Nitrous Oxide on Respiratory System Resistance after Tracheal Intubation." Anesthesiology 86, no. 6 (June 1, 1997): 1294–99. http://dx.doi.org/10.1097/00000542-199706000-00010.
Анотація:
Background After tracheal intubation, lung resistance and therefore respiratory system resistance (R[rs]) routinely increase, sometimes to the point of clinical bronchospasm. Volatile anesthetics generally have been considered to be effective bronchodilators, although there are few human data comparing the efficacy of available agents. This study compared the bronchodilating efficacy of four anesthetic maintenance regimens: 1.1 minimum alveolar concentration (MAC) end-tidal sevoflurane, isoflurane or halothane, and thiopental/nitrous oxide. Methods Sixty-six patients underwent tracheal intubation after administration of 2 microg/kg fentanyl, 5 mg/kg thiopental, and 1 mg/kg succinylcholine. Vecuronium or pancuronium (0.1 mg/kg) was then given to ensure paralysis during the rest of the study. Postintubation R(rs) was measured using the isovolume technique. Maintenance anesthesia was then randomized to thiopental 0.25 mg x kg(-1) x min(-1) plus 50% nitrous oxide, or 1.1 MAC end-tidal isoflurane, halothane, or sevoflurane. The R(rs) was measured after 5 and 10 min of maintenance anesthesia. Data were expressed as means +/- SD. Results Maintenance with thiopental/nitrous oxide failed to decrease R(rs), whereas all three volatile anesthetics significantly decreased R(rs) at 5 min with little further improvement at 10 min. Sevoflurane decreased R(rs) more than either halothane or isoflurane (P < 0.05; 58 +/- 14% of the postintubation R(rs) vs. 69 +/- 20% and 75 +/- 13%, respectively). Conclusions After tracheal intubation in persons without asthma, sevoflurane decreased R(rs) as much or more than isoflurane or halothane did during a 10-min exposure at 1.1 MAC.
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Hipp, Udo. "Erfolg mit automatisierter 5-Achs-Bearbeitung." VDI-Z 164, no. 06 (2022): 48–50. http://dx.doi.org/10.37544/0042-1766-2022-06-48.
Анотація:
Damit ein innovativer Zulieferbetrieb schnell auf ständig wechselnde Kundenwünsche eingehen kann, war eine Aufrüstung in der Produktion vonnöten. Für ausreichende Flexibilität und Kapazität sorgt seit Kurzem ein neues 5-Achs-Bearbeitungszentrum von Hermle, automatisiert mit einem „RS 2“-Robotersystem.
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Mortuza, Shamim, Benjamin Chin-Yee, Tyler E. James, Ian H. Chin-Yee, Benjamin D. Hedley, Jenny M. Ho, Lalit Saini, et al. "Myelodysplastic Neoplasms (MDS) with Ring Sideroblasts or SF3B1 Mutations: The Improved Clinical Utility of World Health Organization and International Consensus Classification 2022 Definitions, a Single-Centre Retrospective Chart Review." Current Oncology 31, no. 4 (March 29, 2024): 1762–73. http://dx.doi.org/10.3390/curroncol31040134.
Анотація:
Myelodysplastic neoplasms (MDS) with ring sideroblasts (RS) are diagnosed via bone marrow aspiration in the presence of either (i) ≥15% RS or (ii) 5–14% RS and an SF3B1 mutation. In the MEDALIST trial and in an interim analysis of the COMMANDS trial, lower-risk MDS-RS patients had decreased transfusion dependency with luspatercept treatment. A total of 6817 patients with suspected hematologic malignancies underwent molecular testing using a next-generation-sequencing-based genetic assay and 395 MDS patients, seen at our centre from 1 January 2018 to 31 May 2023, were reviewed. Of these, we identified 39 evaluable patients as having lower-risk MDS with SF3B1 mutations: there were 20 (51.3%) males and 19 (48.7%) females, with a median age of 77 years (range of 57 to 92). Nineteen (48.7%) patients had an isolated SF3B1 mutation with a mean variant allele frequency of 35.2% +/− 8.1%, ranging from 7.4% to 46.0%. There were 29 (74.4%) patients with ≥15% RS, 6 (15.4%) with 5 to 14% RS, one (2.6%) with 1% RS, and 3 (7.7%) with no RS. Our study suggests that a quarter of patients would be missed based on the morphologic criterion of only using RS greater than 15% and supports the revised 2022 definitions of the World Health Organization (WHO) and International Consensus Classification (ICC), which shift toward molecularly defined subtypes of MDS and appropriate testing.
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Millichap, J. Gordon. "Acyl-CoA Dehydrogenase Deficiency and RS." Pediatric Neurology Briefs 8, no. 5 (May 1, 1994): 37. http://dx.doi.org/10.15844/pedneurbriefs-8-5-7.
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García-Estevez, Laura, Ana C. Contreras, Isabel Calvo, Maria Fernandez Abad, Juan J. de la Cruz, Sofia Perea, Ana Suárez, Fernando López-Ríos, and Manuel Hidalgo. "Can Oncotype DX recurrence score (RS) be used in luminal A and luminal B breast cancer patients (pts) to predict the likely benefit of chemotherapy? A retrospective study in the Spanish population." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e11006-e11006. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e11006.
Анотація:
e11006 Background: The 2011 St Gallen guidelines recommend the use of Ki67 as a surrogate marker for luminal A and Luminal B breast cancer subtypes. Pts with luminal B subtypes should be considered for adjuvant chemotherapy. The guidelines also recognize the Oncotype DX RS as a predictor of chemotherapy benefit. The aim of this study is to assess the distribution of the RS in luminal A and luminal B breast cancer subtypes as defined by Ki67. Methods: Data from 91 pts with invasive breast cancer for which Oncotype DX results and pathology data were available. Pathological assessment was evaluated by the same pathologist. Estrogen (ER) and progesterone (PR) receptor was assessed by immunostaining (cut-off 10% nuclear staining). Ki67 was assessed by IHC [high (≥14%) and low (< 14%)]. Grading was performed by using Nottingham grading system. Results: Median age: 50 years (range: 35-78); premenopausal status: 49 pts (53.8%). Median tumor size: 1.5 cm (0, 3-6); Median of Ki 67 index: 15. 5 (range: 3-63); Median ER: 93 (35-100) and PR: 85(0-100). Sixty nine pts (75.8%) had negative-lymph nodes. RS was low in 56 (61. 5%) cases, intermediate in 24 (26. 4%), and high in 11 (12. 1%). The median RS was 16 (range 3-55). Forty six (51%) tumors were classified as luminal B (according to high Ki 67) and 38 (41.7%) as Luminal A. In the Luminal B group RS was low in 28 (61%) pts, intermediate in 10 (22%) and high in 8 (17%) while in the Luminal A group 23 (61%) had low RS; 13 (34%) intermediate and 2 (5%) high RS. RS changed the first treatment recommendation in 23 (50%) cases of Luminal B subtype vs. 10 (26%) cases in Luminal A subtype (p=0.013). Conclusions: Although based in a small case series, the results show that a substantial number (61%) pts with Luminal B breast cancer subtype had a low RS, therefore preserving them from adjuvant chemotherapy treatment. In addition, 5% of patients with Luminal A breast cancer had a high RS and thereby likely to benefit from chemotherapy. The wide range of RS in both Luminal B and Luminal A breast cancer subtypes confirm the important role of Oncotype DX in treatment decision- making.