Статті в журналах з теми "338.174 98"
Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: 338.174 98.
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 статей у журналах для дослідження на тему "338.174 98".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте статті в журналах для різних дисциплін та оформлюйте правильно вашу бібліографію.
1
Perveen, Professor Irin, Professor Madhusudan Saha, Md Quamrul Hasan, and Malay Kumar Sur Chowdhury. "Clinical Profile of Patients with Incidentally Detected Non-alcoholoic Fatty Liver Disease." Journal of Armed Forces Medical College, Bangladesh 14, no. 1 (August 22, 2019): 4–9. http://dx.doi.org/10.3329/jafmc.v14i1.42712.
Анотація:
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the commonest liver problem worldwide with disease spectrum ranging from steatosis to steatohepatitis, advanced fibrosis and cirrhosis.
Objective: To delineate the clinical and biochemical profile of patients with incidentally detected NAFLD.
Materials and Methods: In this observational study subjects without overt liver disease having sonological evidence of fatty liver underwent thorough physical examinations including anthropometric measurements and investigated for blood glucose level, lipid profile and liver function status. Aspartate aminotransferase (AST) /alanine aminotransferase (ALT) ratio and BMI and diabetes (BARD) score were computed to assess hepatic fibrosis status non-invasively.
Results: Out of 407 final participants, 213 were male and 194 were female. Mean age of the patients was 42.05±10.54 (range 21-71 years). Mean body mass index (BMI) of the subjects was 26.92±3.75Kg/m2. Visceral obesity as measured by abdominal circumference and waist-hip-ratio were found increased in 333(81.81%) and 336(82.5%) subjects respectively. Obesity (BMI > 25 mg/m2), diabetes mellitus, hypertension, and metabolic syndrome (MS) were present in 68.8%, 48.2%, 36.4%, and 87.5% patients respectively. Cholesterol, high density lipoprotein, low density lipoprotein and triglyceride were found increased in 47.7% (n=194), 83.05% (n=338), 42.8%(n=174) and 80.59%(n= 328) NAFLD patients respectively. Elevated AST and ALT levels were found in 98 (24.1%) and 233 (57.0%) patients, respectively. AST/ALT ratio >1 and BARD score >2 were found in 27.5% (n=112) and 29.2% (n=119) patients respectively.
Conclusion: In Bangladesh incidentally detected NAFLD patients are predominantly middle aged and obese. MS and hypertriglyceridaemia are highly prevalent among them. Around one fourth of them have evidence of advanced fibrosis non-invasively.
Journal of Armed Forces Medical College Bangladesh Vol.14(1) 2018: 4-9
2
Coltro, Giacomo, Paola Guglielmelli, Giada Rotunno, Carmela Mannarelli, Chiara Maccari, Costanza Salvadori, Fiorenza Irushani Vanderwert, Francesco Mannelli, Cristina Salvati, and Alessandro Vannucchi. "Mutation Landscape and Prognostic Correlates of ASXL1 Variants in Primary and Secondary Myelofibrosis." Blood 138, Supplement 1 (November 5, 2021): 2578. http://dx.doi.org/10.1182/blood-2021-148685.
Анотація:
Abstract Introduction: Myelofibrosis (MF), whether primary (PMF) or secondary (SMF) to polycythemia vera or essential thrombocytemia, is characterized by a complex and partially undeciphered molecular architecture. Besides mutations in driver genes (JAK2, CALR, MPL), somatic mutations in selected myeloid-associated genes have been shown to impact prognosis of MF patients (pts). Among these, ASXL1 mutations (ASXL1MTs) are associated with poor outcomes in myeloid malignancies including PMF, where they are included in the category of "high molecular risk" (HMR) mutations along with EZH2MTs, IDH1/2MTs, and SRSF2MTs (Vannucchi AM, Leukemia 2013). However, a recent study (Luque Paz D, Blood Adv 2021) questioned the value of ASXL1MTs in MF. The current study aimed at further characterizing the prognostic role of ASXL1MTs in MF. Methods: After IRB approval, pts with WHO-defined MF were included in the study. Mutational analysis by targeted NGS was performed as previously described (Guglielmelli P, JCO 2017). All deposited variants were manually curated to assess pathogenicity. In this study, we also used the molecular model proposed by Luque Paz et al. that identifies 4 genetic groups: TP53MT; High-risk (≥1 mutation in EZH2, CBL, U2AF1, SRSF2, IDH1/2); ASXL1MT-only; and "Others". Results: A total of 525 pts were included in the study, including 331 (63%) PMF and 194 (37%) SMF. Median age at diagnosis was 89 (18-90) years, 314 (60%) were male. The median follow-up time was 80 (98% CI, 68-90) months. Overall, 324 (62%) pts were JAK2MT, 126 (24%) CALRMT, 24 (5%) MPLMT, 40 (8%) triple negative (TN), and 11 (2%) double mutated. Among non-driver genes, ASXL1MTs were found in 158 (30%) pts, EZH2MTs in 45 (9%), SRSF2MTs in 37 (7%), NRASMTs in 30 (6%) U2AF1MTs in 27 (5%), TP53MTs and CBLMTs in 25 (5%) each, IDH1/2 MTs in 18 (3%), and KRAS MTs in 15 (3%). Pts in the HMR category were 125 (38%) in PMF and 63 (32%) in SMF. According to the above model, distribution of pts was as follows: TP53MT n=25 (5%), High-risk n=137 (26%), ASXL1MT-only n=64 (12%), and Others n=299 (57%). Pts in the TP53MT and ASXL1MT-only groups were more likely to be diagnosed with SMF compared to pts in the High-risk and Others groups (44% and 48% vs 28% and 38%, respectively). In addition, the High-risk group was enriched in TN pts (16%), while CALRMTs were more common in the ASXL1MT-only and Others compared to the TP53MT and High-risk groups (25% and 27% vs 12% and 18%, respectively). In univariate analysis, the TP53MT and High-risk groups were associated with the worst overall survival (OS), with median values of 38 (14-110) and 55 (45-85) months (P=.0039), respectively (Fig 1A). Albeit remarkably better, the OS of pts in the ASXL1MT-only group was inferior compared to pts in the Others group (median 124 [91-156] vs 193 [142-NR] months; P=.0118) (Fig 1A). We then analyzed separately PMF and SMF cohorts. In the former, the TP53MT and High-risk groups remained associated with the worst OS (median 58 [20-126] vs 55 [36-85] months), although with no significant difference, likely due to the low frequency (4%) of TP53MTs mutations in PMF (Fig 1B). Concurrently, the negative prognostic impact of the ASXL1MT-only group was confirmed in comparison to the Others group (median 103 [78-NR] vs 320 [178-NR] months; P=.0170). In pts with SMF, while the TP53MT group (6%) had by far the worst OS (median 13 [6-NR] months), the OS of the ASXL1MT-only group (median 141 [56-171] months) was comparable to that of the Others group (median 131 [106-NR] months; P=.5188) and not different from the High-risk group (median 58 [45-174] months; P=.3606) (Fig 1C). In a further analysis including only pts in the High-risk group, ASXL1MTs were found in 62% and 63% of patients with PMF and SMF, respectively. In survival analysis, the presence of ASXL1MTs was associated with an increased risk of death only in PMF (median OS 47 [31-73] vs 102 [34-317] months; P=.0240), unlike in SMF (median OS 90 [47-174] vs 25 [16-338] months; P=.3296) (Fig 1D-E). Conclusion: In the current study, we critically re-addressed the prognostic impact of ASXL1MTs by applying a genetic model recently developed by Luque Paz et al. to our cohort of molecularly annotated, WHO-defined MF pts. Overall, our results confirm that ASXL1MTs -even in the absence of other co-occurring high-risk mutations- harbor a negative prognostic impact mainly in PMF. These findings also reinforce the idea that PMF and SMF represent two different biological entities. Figure 1 Figure 1. Disclosures Vannucchi: Incyte: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees; AbbVie: Membership on an entity's Board of Directors or advisory committees.
3
Vasilevich, S. V., E. A. Shaporova, and S. О. Stoyko. "Study of the kinetics of aviation oils thermal conversion under non-isothermal conditions." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 59, no. 4 (December 2, 2023): 318–33. http://dx.doi.org/10.29235/1561-8331-2023-59-4-318-333.
Анотація:
The paper discusses the results of a kinetic study of the thermal decomposition of MS-8P, TN-98, and TN-600 aviation oils under conditions of continuous heating at a constant rate of 5 K/min to a temperature of 1 073 K. An integral method was used to describe the reaction mechanism and determine the macrokinetic parameters. It has been established that, from a phenomenological point of view, the average reaction of aviation oils conversion under the experimental conditions corresponds to the reaction model described by the surface-limited reaction equation (MS-8P), the power law (TN-98) and the model described by the three-dimensional diffusion-limited reaction equation (TN-600). When dividing the averaged reaction into two reactions (the first is completed at a temperature of 550–600 K, the second at a temperature of 638–655 K), it is determined that the first reaction is described by the reaction equation of the 2nd order (MS-8P), the first order (TN-98) and the reaction equation of one-dimensional diffusion (TN-600), and the second the reaction equation of the first order (three types of oil). The activation energy of the first reaction was 99 kJ/mol (MS-8P), 145.6 kJ/mol (TN-98) and 57.4 kJ/mol (TN-600), the value of the pre-exponential factor was – 144 241 567 min–1 (MS-8P), 62 161 395 942 min–1 (TN-98) and 236.16 min–1 (TN600). The activation energy of the second reaction is 160 kJ/mol (MS-8P), 91.6 kJ/mol (TN-98) and 127.1 kJ/mol (TN-600), the pre-exponential factor is 8.81 ‧ 1011 min–1 (MS-8P), 1.26 ‧ 104 min–1 (TN-98) and 2.04 ‧ 108 min–1 (TN-600). It is shown that the use of these values of the activation energy and the pre-exponential factor leads to agreement between the calculated values of the degree of decomposition of the studied oil samples and the experimental ones in the range of values of the degree of decomposition from 0 to 1.
4
Bush, Edward W., Allen D. Owings, Dennis P. Shepard, and James N. McCrimmon. "Mowing Height and Nitrogen Rate Affect Turf Quality and Vegetative Growth of Common Carpetgrass." HortScience 35, no. 4 (July 2000): 760–62. http://dx.doi.org/10.21273/hortsci.35.4.760.
Анотація:
Common carpetgrass (Axonopus affinis Chase), mowed at 3.8 or 7.6 cm and fertilized with at least 98 kg·ha–1 N, maintained acceptable lawngrass quality during the 1993 and 1994 growing seasons. Cumulative vegetative growth (CVG) quality and coverage were increased in mowed plots fertilized with 98, 147, or 196 kg·ha–1 N. Unsightly seedheads were a problem in nonmowed plots 3 weeks after the start of the experiment, but did not appear in the mowed plots. Our results indicate that mowing common carpetgrass at 3.8 or 7.6 cm and fertilizing with 98, 147, or 196 kg·ha–1 N will provide acceptable turfgrass quality.
5
Foeldvari, I., J. Klotsche, O. Kasapcopur, A. Adrovic, K. Torok, M. T. Terreri, A. P. Sakamoto, et al. "POS0079 PATIENTS WITH JUVENILE SYSTEMIC SCLEROSIS HAVE A DISTINCT PATTERN OF ORGAN INVOLVEMENT.RESULTS FROM THE JUVENILE SYSTEMIC SCLEROSIS INCEPTION COHORT. WWW.JUVENILE-SCLERODERMA.COM." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 247.2–247. http://dx.doi.org/10.1136/annrheumdis-2021-eular.799.
Анотація:
Background:Juvenile systemic sclerosis (jSSc) is a rare disease with a prevalence of around 3 in 1,000,000 children. To better capture the clinical manifestations of jSSc the juvenile systemic sclerosis inception cohort (jSScC) has been prospectively enrolling patients with predetermined clinical variables over the past 12 years. One of the goals is to study the demographic, clinical features, and physician and patient reported outcome differences between those with juvenile limited cutaneous (lc) compared to diffuse cutaneous (dc) disease subtypes, to determine if characteristics are similar or different between dc and lc jSSc.Objectives:Evaluation of the baseline clinical characteristics of jSSc patients in the jSScC. Compare clinical phenotype between diffuse (dcjSSc) and limited cutaneous (lcjSSc) subtypes.Methods:Demographic, physical examination, organ system evaluation, autoantibody profile, treatment, and patient and physician reported outcome variables were evaluated from the jSSc Inception cohort and summary statistics applied using chi-square test and Mann Whitney U-test comparing lcjSSc and dcjSSc subtypes.Results:At the time of data extraction, 175 jSSc patients were enrolled in the cohort, 81% were Caucasian and 81% female. Diffuse cutaneous jSSc subtype predominated (73%). Mean disease duration was 3.1 year (±2.7). Mean age at Raynaud´s was 10 years (+3.8) and mean age of first non-Raynaud´s was 10.2 years (±3.8). Significant differences were found between dcjSSc versus lcjSSc, regarding several clinical characteristics. Patients with diffuse cutaneous subtype had significantly higher modified Rodnan skin score (p=0.001), presence of sclerodactyly (p=0.02), presence of Gottron’s papules (p=0.003), presence of telangiectasia (p=0.001), history of digital tip ulceration (p=0.01), and frequency of elevated CK value (p=0.04). Cardiac involvement was significantly higher in limited cutaneous jSSc subtype (p=0.02). Diffuse cutaneous jSSc patients had significantly worse scores for Physician Global Assessment of disease activity (38 vs 25; p=0.002) and disease damage (34 vs 19; p=0.008).Table 1.Comparison of demographic data and significant differences between dcjSSc and lcjSSc at time of inclusionWhole CohortN=175Diffuse SubtypeN=128Limited SubtypeN=47P valueFemale to Male Ratio4.3:1 (142/33)4.1:1 (103/25)4.8:1 (39/8)0.829Cutaneous subtypeDiffuse subtype73% (128)1280Limited subtype27% (47)047Mean Disease duration (years)3.1 (± 2.7)3.3 (± 2.9)2.6 (± 2.2)0.135Mean age of onset of Raynaud´s (years)10.0 (± 3.8)17 non-Raynaud9.8 (± 3.6)10 non-Raynaud10.6 (± 4.3)7 non-Raynaud0.219Mean age of onset of non-Raynaud´s (years)10.2 (± 3.9)10.0 (± 3.7)10.9 (± 4.3)0.173Disease modifying drugs88% (154)89% (114)85% (40)0.446CutaneousMean modified Rodnan skin score14.3 (0-51)17.4 (0-51)6.1 (0-24)0.001Gottron Papules27% (46/171)33% (41/124)11% (5)0.003Sclerodactyly78% (126/162)82% (98/119)65% (28/43)0.020Laboratory valuesElevated CK25% (30/122)30% (26/88)12% (4/34)0.041VascularTelangiectasia36% (56/154)44% (49/111)16% (7/43)0.001History of ulceration53% (91/173)61% (77/127)30% (14/46)0.001CardiacCardiac Involvement6% (10)2% (3)15% (7)0.002Patient Related OutcomesPhysician global disease activity(0-100) min -max35(0-90) n=14138(0-90) n=10825(0-80) n=330.002Physician global disease damage(0-100) min -max31(0-85) n=14034(0-85) n=10819(0-60) n=320.008Conclusion:Results from this large international cohort of jSSc patients demonstrate significant differences between dcjSSc and lcjSSc patients. According to the general organ involvement and physician global scores, the dcjSSc patients had significantly more severe disease. These observations strengthen our previous findings of the unique organ pattern of pediatric patients.Supported by the “Joachim Herz Stiftung”Disclosure of Interests:None declared.
6
Hofmann, Jan C., and Dobri D. Kiprov. "Leukapheresis (WBC Depletion) Treatment for Patients with Acute Leukemia and Blast Crisis Can Enable a High Percentage of Patients to Undergo Induction Chemotherapy." Blood 118, no. 21 (November 18, 2011): 4281. http://dx.doi.org/10.1182/blood.v118.21.4281.4281.
Анотація:
Abstract Abstract 4281 Introduction: Several retrospective, cohort studies have demonstrated that leukapheresis (WBC depletion) treatment in patients (pts) with acute leukemia and concurrent hyperleukocytosis and blast crisis decreases short-term mortality rate, but does not increase overall survival. However, pts selected in these studies for leukapheresis treatment are often sicker and have a higher underlying mortality rate (than pts who do not receive such treatment). No randomized controlled trials assessing the efficacy of leukapheresis in this subset of pts with acute leukemia have been performed. Methods and Clinical Presentation: Between January, 2006 and June, 2010, Apheresis Care Group (ACG) treated 1,636 pts performing 13,587 therapeutic apheresis treatments (txs). Of this patient cohort, 126 (7.7%) pts had acute leukemia with clinical and/or laboratory evidence of blast crisis and received leukapheresis treatment. 77 pts had acute myelogenous leukemia (AML) and received 174 leukapheresis txs; 49 pts had acute lymphoblastic leukemia (ALL) and received 158 txs. AML pts presented with median WBC 204 × 109/L (range 66–418 × 109/L) and 87% pts had blast crisis (defined as blast percent >75% or blast count >100 × 109/L). Median age was 54 years (6.5–85 years); 61% pts were male. Of CNS or pulmonary symptoms (sxs) of leukostasis (CNS sxs defined as: headache, lethargy, confusion, or visual abnormalities; pulmonary sxs defined as: shortness of breath, hypoxia, or chest x-ray infiltrates without evidence of pneumonia), 13% pts had no sxs, 52% pts had 1 sx, and 35% pts had 2 sxs. ALL pts presented with median WBC 338 × 109/L (104–736 × 109/L) and 82% pts had blast crisis. Median age was 22 years (4–80 years); 64% pts were male. Of sxs of leukostasis, 25% pts had no sxs, 63% pts had 1 sx, and 12% pts had 2 sxs. Treatment: All pts received a course of leukapheresis (Lp) with the following objectives: 1) decreasing the risk of thrombotic and hemorrhagic complications related to leukostasis, and 2) stabilizing pts for induction chemotherapy. WBC treatment goals were defined as: WBC count (ct) <55 × 109/L for AML pts, and WBC ct <80 × 109/L for ALL pts. AML pts received a median of 2 Lp txs (range 1–5 txs); ALL pts underwent a median of 2 Lp txs (1–7 txs). Results: Outcomes were evaluated by the percentage of pts who: 1) reached the WBC treatment goal and, 2) received induction chemotherapy. “Improved” outcome was defined as pts who reached their WBC treatment goal during leukapheresis therapy; “stabilized” was defined as pts who achieved >50% reduction in WBC ct, but did not reach their WBC goal; and “unchanged” was defined as pts who achieved neither. In the AML cohort, 76% pts improved, 23% pts stabilized, and 1% pts were unchanged. In the ALL cohort, 63% pts improved, 34% pts stabilized, and 3% pts were unchanged. For AML pts, the median final WBC ct was 53 × 109/L (range 17–133 × 109/L) and 92% pts received induction chemotherapy. For ALL pts, the median final WBC ct was 76 × 109/L (range 30–294 × 109/L) and 98% pts received induction chemotherapy. 7 (9%) AML pts and 1 (1%) ALL pt expired within 1–4 days after completing course of leukapheresis. Of the 8 expired pts, 75% had both blast crisis and 2 sxs of leukostasis; 38% had intracranial hemorrhage or CVA; and 88% were hypotensive, receiving mechanical ventilation, and unable to tolerate induction chemotherapy. Conclusion: Carefully selected patients with acute leukemia and evidence of impending thrombosis may benefit significantly from leukapheresis therapy. A limited number of treatments (median of 2 treatments) can enable a high percentage of patients to receive induction chemotherapy and may improve short-term clinical outcomes. Leukapheresis treatments are considered emergency procedures as they are often life saving. Disclosures: Hofmann: Fresenius Medical Care: Consultancy. Kiprov:Fresenius Medical Care: Employment.
7
Muharam, Ricky Santoso, Sudaryatie Sudaryatie, and Danang Prasetyo. "Penguatan Nilai Karakter Pendidikan Antikorupsi Melalui Mata Kuliah Pendidikan Kewarganegaraan." Yustitiabelen 8, no. 1 (June 30, 2022): 59–69. http://dx.doi.org/10.36563/yustitiabelen.v8i1.524.
Анотація:
Penelitian ini termasuk deskriptif kualitatif dengan menganalisis data dari 328 responden dari tiga perguruan tinggi (PT) di Yogyakarta. Dengan menggali data survey dalam survey/survey menggunakan mixed survey. Data dalam survei ini berasal dari data primer dan data sekunder. Hasil survei ini menjelaskan nilai pendidikan antikorupsi. Kepribadian: Dari 328 siswa yang disurvei yang menganggap nilai kejujuran itu penting, mereka sering melakukannya. Jumlah tanggapan 171 (52,1%), nilai tanggung jawab 162 responden (49,4%), nilai kasih sayang 114 (36,7%), nilai sederhana 98 responden (29,9%), nilai disiplin 75 responden (22,9%), nilai ketekunan 72 responden (22%), 68 responden dengan nilai independen (20,7%). ), Nilai wajar 66 responden (20,1%) dan nilai keberanian 64 responden (19,9%). Nilai-nilai kepribadian tersebut dapat dibagi menjadi tiga aspek: inti, etos kerja, dan sikap yang menghasilkan etika anti korupsi dalam profesionalisme berintegritas.
8
Kotsiuba, S. "Breeding of early-maturing inbred maize lines within the collection gene pool of Ukraine." Collected Works of Uman National University of Horticulture 1, no. 98 (June 25, 2021): 280–87. http://dx.doi.org/10.31395/2415-8240-2021-98-1-280-287.
Анотація:
The results of the study of inbred lines of corn on the basis of economically valuable features, such as: growing season, productivity, moisture yield. To distribute our maize material by precocity, a number of studies were conducted, namely: estimating the length of the growing season "shoots-full ripeness", which was determined in days, and a very important indicator-grain moisture at harvest as a percentage, it allowed to distribute two groups: early-maturing – (106–114) and middle-early – 114–123 days. Over the years of testing, the weather conditions varied considerably, which made it possible to evaluate the material under study in detail. In 2020, the growing season in the early-maturing group of lines was within 104.0 days, which is almost five days less in 2019. This trend was also observed for the group of middle-early lines. At the same time, the longer vegetation period was in 2019. Therefore, the aim of our study was to analyze the rate of moisture yield of corn grain of the studied lines of different maturity groups. The conducted researches allowed to trace the dynamics of grain moisture yield of corn lines of different maturity groups, to determine the variability of grain moisture of hybrids in different periods of grain maturation. 2019 was more favorable for growing corn, the plants formed a large vegetative mass, but the grain had a high humidity during the harvest period. This is due to a significant amount of precipitation (46.0 mm) in September 2019. Lines that had high harvest humidity were characterized by a long growing season, such as Um 337 and VIR 44. The group of the most productive included lines Um 337, Um 331, F7 and line MAN 053, which were ahead. The following year, Mind 337 and Mind 331 as a whole confirmed their positions, while F7 and MAN 053 yielded significantly lower yields.
9
Sørbye, Sveinung Wergeland, Bente Marie Falang, and Mona Antonsen. "Performance of a 7-Type HPV mRNA Test in Triage of HPV DNA Primary Screen Positive Women Compared to Liquid-Based Cytology." Journal of Molecular Pathology 4, no. 2 (March 25, 2023): 69–80. http://dx.doi.org/10.3390/jmp4020008.
Анотація:
Background: A plethora of data supports HPV-based screening to be the preferred strategy for cervical cancer prevention. The shift to a more sensitive first-line test brings the need of effective triage up for discussion. Currently, most algorithms apply cytology as a triage of HPV-DNA positive women. This study compared the performance of a 7-type HPV-mRNA test to cytology. Methods: From 1 January 2019 until 31 December 2021, cervical samples from 58,029 women were examined at the University Hospital of North Norway. A total of 30.5% (17,684/58,029) fulfilled the criteria for HPV-DNA primary screening. All positive samples were triaged by cytology and followed-up according to national guidelines through 2022. Additionally, a 7-type HPV-mRNA test was applied. The study endpoint was a histologically confirmed high-grade lesion (CIN2+). Results: A total of 5.6% (990/17,684) had positive HPV-DNA test, 97.2% (962/990) with valid HPV-mRNA results. A total of 55.5% (534/962) had abnormal cytology (ASC-US+), and 35.1% (338/962) had a positive HPV-mRNA test. A total of 13.9% (134/962) had CIN2+. The sensitivity (CIN2+) of cytology versus the HPV-mRNA test was 76.1% (102/134) versus 73.1% (98/134), p = 0.67. The specificity was 47.8% (396/828) versus 71.0% (588/624), p < 0.001. PPV was 19.1% (102/534) and 29.0% (98/338), p < 0.001, respectively. The number of colposcopies per CIN2+ detected by cytology and HPV-mRNA test was 5.2 and 3.1. Conclusion: The 7-type HPV mRNA test was significantly more specific than cervical cytology in a triage of HPV-DNA positive women. Using this biomarker as the threshold for colposcopy may better balance the benefits and harms of screening.
10
Uikey, Shivani, Stuti Sharma, Pawan K. Amrate, and M. K. Shrivastava. "Identification of Rich Oil-Protein and Disease Resistance Genotypes in Soybean [Glycine max (L.) Merrill]." International Journal of Bio-resource and Stress Management 13, no. 5 (May 31, 2022): 497–506. http://dx.doi.org/10.23910/1.2022.2478.
Анотація:
A study was undertaken on oil-protein content and their relation with yield and evaluation of resistance for aerial blight and frog eye leaf spot diseases in soybean during kharif (July−December, 2019) at J.N.K.V.V., Jabalpur, Madhya Pradesh, India. The experiment was laid out using augmented block design with 154 genotypes of soybean including four check varieties namely JS 20-34, JS 20-98, JS 335 and NRC 86. Per cent disease severity was measured at peak of disease during seed formation stage (R5-R6). Yield and 100 seed weight were recorded at time of harvesting. Oil and protein content from harvested yield was estimated by using standard methods of association of official analytical chemists (AOAC). The results revealed that oil content varied from 16.8−20.2% and protein content from 36.1−41.2% in all 154 genotypes. Per plant average seed yield (3.9-15.1 g) and hundred seed weight (6.7−14.7 g) were also varied from genotypes to genotypes. The correlation between oil and protein was highly negative (r=-0.620**, p=0.01). This investigation identified ten genotypes with high oil (>20%) and fourteen genotypes with high protein (>40%) content. Among which JS 20-104, Cat 473B and RKS 24 were higher in protein, and Cat 48, Cat 330 and JS 20−69 were higher in oil content. In disease evaluation, eleven genotypes namely Cat 473B, Cat 60, Cat 642, JS 20−76, JSM 122, JSM 126A, JSM 126B, JSM 203, JSM 287, RKS 66 and SQL 89 exhibited dual resistance for aerial blight as well as frog eye leaf spot were screened out. The result showed that variation in oil-protein content and disease resistance depends on the genotype.
11
Palladini, Giovanni, Tiziana Bosoni, Paolo Milani, Laura Pirolini, Andrea Foli, Filomena Li Bergolis, Francesca Lavatelli, et al. "Use of the Novel Monoclonal Assay for the Measurement of Circulating Free Light Chain in the Diagnosis, Prognostication of Survival and Assessment of Response to Therapy in AL Amyloidosis." Blood 120, no. 21 (November 16, 2012): 3913. http://dx.doi.org/10.1182/blood.v120.21.3913.3913.
Анотація:
Abstract Abstract 3913 The possibility of measuring the circulating free light chains (FLC) improved our ability to detect the amyloidogenic clone, allowed refined risk stratification in combination with cardiac biomarkers, and provided a formidable tool for assessing response to treatment in AL amyloidosis. Recently, a novel method for FLC quantitation based on monoclonal antibodies has been developed. We evaluated its performance in the diagnosis, prognostication of survival, and response assessment in 353 consecutive newly diagnosed patients with AL amyloidosis enrolled between 2007 and 2011. Serum and urine immunofixation electrophoresis (IFE) was performed with a Hydragel 2IF/BJ(HR) kit on a Hydrasis apparatus (Sebia). Serum FLC concentration was measured in duplicate on frozen sera by a polyclonal (Binding Site) and a monoclonal (Siemens) immunoassay on a Behring BNII nephelometer. Reference ranges are k-FLC 3.3–19.4 mg/L, l-FLC 5.7–26.3 mg/L, k/l ratio 0.26–1.65 for the Binding Site (BS) assay, and k-FLC 6.7–22.4 mg/L, l-FLC 8.3–27.0 mg/L, k/l ratio 0.31–1.56 for the Siemens (S) assay. Response was evaluated 3 months after treatment initiation. The deposited amyloidogenic light chain identified by immuno electron microscopy was k in 69 patients (19%) and l in 284 (81%). Fifteen patients (4%) were excluded from the calculation of the diagnostic sensitivity because a biclonal gammapathy was detected by IFE. The two FLC assays had similar diagnostic sensitivity (Table 1). We calculated the concordance correlation coefficient to evaluate the agreement between the two assays, which was better for k (0.92, 95%CI 0.87–0.91) than for l (0.78, 95%CI 0.73–0.82) FLC. A total of 161 patients (46%) died. Median survival was 31 months. We evaluated the prognostic relevance of the difference between involved (amyloidogenic) and uninvolved FLC concentration (dFLC). Median values of dFLC measured with the two methods were 180 mg/L by BS and 165 mg/L by S. Patients with dFLC greater than the median value had a worse outcome (2 year survival 43% vs. 65%, P=0.001, by BS; 42% vs. 66%, P=0.001, by S). These thresholds were incorporated into a staging system modeled on the revised Mayo Clinic system (Figure 1). The S assay provided better discrimination between stages III and IV. We evaluated the use of the S assay in the response criteria of the International Society of Amyloidosis (ISA). A serum sample collected 3 months after treatment initiation was available in 226 patients. Among them, baseline dFLC was ≥50 mg/L (evaluable for response) in 171 subjects with the BS, in 170 with the S assay, and in 146 patients by both methods. Table 2 reports the response categorization according to the two methods. The greatest discrepancy was observed in the partial response group, although also the very good partial response group presented notable deviations. The novel monoclonal FLC assay has a diagnostic sensitivity comparable to that of the standard polyclonal assay and can be used for prognostic stratification. However, response assessment presents significant discrepancies between the two methods, indicating that further studies are needed to assess the performance of the S assay in the evaluation of response. Table 1. Diagnostic sensitivity of IFE and FLC k/l ratio by Binding Site (BS) and Siemens (S) in 338 patients with systemic AL amyloidosis Patients with k clones (N=67) Patients with l clones (N=271) Overall population (N=338) N positive % (95% CI) N positive % (95% CI) N positive % (95% CI) Serum IFE 55 82 (71–90) 259 96 (93–98) 314 93 (90–95) Urine IFE 54 81 (69–89) 239 88 (84–92) 293 87 (83–90) Serum and urine IFE 56 84 (72–91) 262 97 (94–98) 318 94 (91–96) FLC k/l ratio BS 65 97 (90–100) 214 80 (74–83) 279 82 (78–86) FLC k/l ratio S 60 89 (80–96) 225 83 (78–87) 285 84 (80–88) Serum and urine IFE + FLC k/l ratio BS 67 100 (96–100) 264 97 (95–99) 331 98 (96–99) Serum and Urine IFE + FLC k/l ratio S 64 95 (87–99) 268 99 (97–100) 332 98 (96–99) Table 2. Concordance between dFLC response with the two assays Number responding by the Siemens assay Response by the Binding Site assay CR VGPR PR NR CR (22 patients) 21 1 0 0 VGPR (29 patients) 1 16 5 7 PR (37 patients) 0 3 18 16 NR (58 patients) 0 3 3 52 Complete response (CR), negative serum and urine immunofixation and normal FLC k/l ratio; very good partial response (VGPR), dFLC concentration after chemotherapy <40 mg/L; partial response (PR), dFLC decrease >50%; no response (NR), all other patients. Disclosures: No relevant conflicts of interest to declare.
12
Atsuta, Yoshiko, Ritsuro Suzuki, Tokiko Nagamura-Inoue, Shuichi Taniguchi, Satoshi Takahashi, Shunro Kai, Hisashi Sakamaki, et al. "Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia." Blood 113, no. 8 (February 19, 2009): 1631–38. http://dx.doi.org/10.1182/blood-2008-03-147041.
Анотація:
Abstract We made a disease-specific comparison of unrelated cord blood (CB) recipients and human leukocyte antigen allele–matched unrelated bone marrow (BM) recipients among 484 patients with acute myeloid leukemia (AML; 173 CB and 311 BM) and 336 patients with acute lymphoblastic leukemia (ALL; 114 CB and 222 BM) who received myeloablative transplantations. In multivariate analyses, among AML cases, lower overall survival (hazard ratio [HR] = 1.5; 95% confidence interval [CI], 1.0-2.0, P = .028) and leukemia-free survival (HR = 1.5; 95% CI, 1.1-2.0, P = .012) were observed in CB recipients. The relapse rate did not differ between the 2 groups of AML (HR = 1.2; 95% CI, 0.8-1.9, P = .38); however, the treatment-related mortality rate showed higher trend in CB recipients (HR = 1.5; 95% CI, 1.0-2.3, P = .085). In ALL, there was no significant difference between the groups for relapse (HR = 1.4, 95% CI, 0.8-2.4, P = .19) and treatment-related mortality (HR = 1.0; 95% CI, 0.6-1.7, P = .98), which contributed to similar overall survival (HR = 1.1; 95% CI, 0.7-1.6, P = .78) and leukemia-free survival (HR = 1.2; 95% CI, 0.9-1.8, P = .28). Matched or mismatched single-unit CB is a favorable alternative stem cell source for patients without a human leukocyte antigen–matched related or unrelated donor. For patients with AML, decreasing mortality, especially in the early phase of transplantation, is required to improve the outcome for CB recipients.
13
Kyriakis, S. C., V. Vassilopoulos, I. Demade, W. Kissels, Z. Polizopoulou, and C. K. Milner. "The effect of virginiamycin on sow and litter performance." Animal Science 55, no. 3 (December 1992): 431–36. http://dx.doi.org/10.1017/s0003356100021139.
Анотація:
AbstractThe present paper discusses the results of a trial study, which was carried out to demonstrate the potential beneficial effects of virginiamycin (VM) on sow and litter performance. VM was added to the sow food at the levels of 0, 20 and 40 mg/kg, for a period of two breeding cycles, covering pregnancy and lactation. VM supplementation of the sow food improved sow performance by: (i) decreasing sow weight loss from farrowing to weaning (first period: 8·78 v. 3·54 v. 2·88 kg, P < 0·05; second period: 8·98 v. 3·93 v. 2·32 kg, P < 0·05), (ii) decreasing the duration of the reproductive cycle (first period: 154·5 v. 152·2 v. 151·2 days, P < 0·05; second period: 153·8 v. 151·5 v. 250·6 days, P < 0·05) and (in) increasing milk fat content (second period: 63·7 v. 81·3 v. 83·3 g/kg, P<0·05). Litter performance was also improved in terms of: (i) litter size at weaning (first period: 8·16 v. 8·88 v. 9·18, P < 0·05; second period: 8·98 v. 9·30 v. 9·76, P < 0·05), (ii) body weight at weaning (first period: 5·78 v. 6·29 v. 6·56 kg, P < 0·05; second period: 5·88 v. 6·38 v. 6·60 kg, P < 0·05), (Hi) average daily gain (first period: 172 v. 189 v. 197 g, P < 0·05; second period: 178 v. 292 v. 198 g, P < 0·05) and (iv) food conversion ratio (first period: 0·356 v. 0·331 v. 0·324, P < 0·05; second period: 0·363 v. 0·334 v. 0·325, P < 0·05). These beneficial effects of VM were more pronounced at the higher of the two inclusion levels.
14
Guerra, Borja, Alfredo Santana, Teresa Fuentes, Safira Delgado-Guerra, Alfredo Cabrera-Socorro, Cecilia Dorado, and Jose A. L. Calbet. "Leptin receptors in human skeletal muscle." Journal of Applied Physiology 102, no. 5 (May 2007): 1786–92. http://dx.doi.org/10.1152/japplphysiol.01313.2006.
Анотація:
Human skeletal muscle expresses leptin receptor mRNA; however, it remains unknown whether leptin receptors (OB-R) are also expressed at the protein level. Fourteen healthy men (age = 33.1 ± 2.0 yr, height = 175.9 ± 1.7 cm, body mass = 81.2 ± 3.8 kg, body fat = 22.5 ± 1.9%; means ± SE) participated in this investigation. The expression of OB-R protein was determined in skeletal muscle, subcutaneous adipose tissue, and hypothalamus using a polyclonal rabbit anti-human leptin receptor. Three bands with a molecular mass close to 170, 128, and 98 kDa were identified by Western blot with the anti-OB-R antibody. All three bands were identified in skeletal muscle: the 98-kDa and 170-kDa bands were detected in hypothalamus, and the 98-kDa and 128-kDa bands were detected in thigh subcutaneous adipose tissue. The 128-kDa isoform was not detected in four subjects, whereas in the rest its occurrence was fully explained by the presence of intermuscular adipose tissue, as demonstrated using an anti-perilipin A antibody. No relationship was observed between the basal concentration of leptin in serum and the 170-kDa band density. In conclusion, a long isoform of the leptin receptor with a molecular mass close to 170 kDa is expressed at the protein level in human skeletal muscle. The amount of 170-kDa protein appears to be independent of the basal concentration of leptin in serum.
15
Wagner, Manfred. "Hämoptysen: Wann ist die Bronchoskopie besonders wertvoll?" Kompass Pneumologie 7, no. 3 (2019): 146–48. http://dx.doi.org/10.1159/000499953.
Анотація:
Background: Bronchoscopy plays a key role to diagnose the etiology, to localize the site, and to identify the sources of the bleeding in patients with hemoptysis, but the ideal timing of an endoscopic examination is still unclear. Methods: We performed a secondary analysis of an observational and multicenter study, aimed at evaluating the epidemiology of hemoptysis in Italy and the diagnostic yield of the most frequently prescribed examinations. The aim of the study was to evaluate whether an early bronchoscopy (i.e., performed during active bleeding/≤48 h after hemoptysis stopped) helps localize bleeding (i.e., site, lobe, lung) and increase diagnostic yield in comparison with a delayed examination. Results: Four hundred eighty-six consecutive adult patients (69.2% males; median [IQR] age: 67 [53-76] years) with hemoptysis requiring an etiological diagnosis and undergoing bronchoscopy were recruited. Bleeding focus could be located more frequently in case of moderate-severe bleedings than in cases of mild hemoptysis (site: 70/154, 45.4%, VS. 73/330, 22.1%; p-value < 0.0001; lobe: 95/155, 61.3%, VS. 95/331, 28.7%; p-value < 0.0001; lung: 101/155, 65.1%, VS. 111/331, 33.5%; p-value < 0.0001). Early bronchoscopy showed a higher detection rate of bleeding source in comparison with delayed examination (site: 76/214, 35.5%, VS. 67/272, 24.6%; p-value = 0.01; lobe: 98/214, 45.8%, VS. 92/272, 33.8%; p-value = 0.007; lung: 110/214, 51.4%, VS. 102/272, 37.5%; p-value = 0.002). Early bronchoscopy did not provide any advantages in terms of increased diagnostic yield, in the total cohort (113/214, 52.8%, VS. 123/272, 45.2%; p-value = 0.10) and in the severity subtypes (mild: 56/128, 43.8%, VS. 88/203, 43.4%; p-value = 0.94; moderate-severe: 57/86, 66.2%, VS. 35/69, 50.7%; p-value = 0.051). Conclusions: Early bronchoscopy helps detect bleeding sources, particularly in cases of moderate-severe hemoptysis, without increasing diagnostic accuracy. Trial registration: ClinicalTrials.gov (identifier: NCT02045394).
16
Tyulyandina, Alexandra, Tatiana Kekeeva, Vera Karaseva, Vera Gorbunova, Larisa Kolomiets, Maxim Filipenko, Irina Demidova, et al. "Comprehensive analysis of germline and somatic BRCA1/2 mutations in ovarian cancer population: Interim results of OVATAR prospective study." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e23109-e23109. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23109.
Анотація:
e23109 Background: The most promising method for the detection of BRCA 1/2 mutations is next-generation sequencing (NGS). There is no enough data about prevalence of large deletions of BRCA mutations and somatic alterations in ovarian cancer (OC). NGS technology is important approach for somatic mutations search in tissue samples. Methods: 498 pts with serous and endometrioid OC were enrolled in OVATAR study (NCT02122588). NGS testing of BRCA1/2 in blood and tumor tissue, multiplex ligation-dependent probe amplification (MLPA) for large deletions in blood were employed. Results: Interim analysis included pair tumor and blood samples from 336 pts (median age 54 (22 - 84) years; family history in 79 (23.5%). The total rate of BRCA1/2 mutations was 29.2% (98/336) pts including 80.6% (79/98) germline mutations and 19.4% (19/98) somatic mutations. Hotspot mutations were detected in 42/98 (42.8%) pts, among them 5382insC mutation was observed in 29.6% (29/98). Blood MLPA was performed in 142 (42.2%) pts; germline large deletions were found in 2 (1.4%) cases. Differences in NGS results for tumor and blood are listed in the table. Conclusions: Application of NGS revealed rare mutations in 57.2% among all detected mutations in OC pts; moreover, NGS in tumor tissue provided a significant increase in BRCA mutations of 19% due to somatic alterations. Large deletions in BRCA1/2 are rare event in OC in our study. [Table: see text]
17
Erdol, Sahin, and Halil Saglam. "Use of complementary and alternative medicine in patients with inherited metabolic disease." Journal of Pediatric Endocrinology and Metabolism 31, no. 10 (October 25, 2018): 1091–98. http://dx.doi.org/10.1515/jpem-2018-0165.
Анотація:
Abstract Background There are no studies on the use of complementary and alternative medicine (CAM) therapies in subjects with inherited metabolic disease (IMD) in the current literature. This study aimed to determine the type, frequency of and reasons for the use, and factors associated with the use of CAM therapies. Methods Subjects included in this study consisted of 335 children (95.7%) and 15 (4.3%) adults with a median age of 5.66±6.16 (0.08–48) years with inherited metabolic disease. A single physician conducted face-to-face interviews with the mother and/or father for pediatric subjects and with the subjects themselves for adults of a normal intelligence. Data were obtained from responses to the questions in the standard survey form. Results Our study included 350 patients in total, of whom 164 (46.9%) were female and 186 (53.1%) male. We found that 144 of the patients (41.1%) had used at least one CAM therapy method. The highest rate of use among the CAM therapy methods was of the mind-body approach therapies (n=98, 28%). This was followed by biologically-based (n=75, 21.4%) and manipulative and body-based (n=5, 1.4%) therapies, respectively. The most commonly used herbal product was herbal tea (n=21, 6%), and the most commonly used dietary supplementation was a royal jelly and pollen mixture (n=9, 2.6%). Significant differences in the subjects’ age, their follow-up duration, their mother’s and father’s ages, and CAM therapy use were identified from sociodemographic data. Conclusions In our study, the use of CAM therapies was determined at a high rate. This is important when dealing with clinical problems and for clinicians who follow-up with IMD subjects and suspect they may be using CAM therapy.
18
Löhr Junior, Alfredo, Paulo Breno Noronha Liberalesso, Gisele Claudino Reck Luzzi, Antonio Carlos de Faria, Maria Julia Camiña Bugallo, and Mara Lucia Schmit Ferreira Santos. "Etiologia e a morbi-letalidade do coma agudo em crianças." Arquivos de Neuro-Psiquiatria 61, no. 3A (September 2003): 621–24. http://dx.doi.org/10.1590/s0004-282x2003000400018.
Анотація:
OBJETIVO: Analisou-se a etiologia e a morbi-mortalidade de 104 crianças em coma agudo, ou seja, com uma pontuação menor ou igual a 8 da escala de Glasgow, internadas na Unidade de Terapia Intensiva do Hospital Infantil Pequeno Príncipe(UTI-HIPP) no período entre março/98 e janeiro/2001. RESULTADOS: A idade variou de 2 meses a 13 anos, com média de 30,3 ± 27,4 meses e mediana de 20 meses, sendo 57 (54,8%) do sexo masculino. O tempo de permanência hospitalar variou de 1 a 114 dias, e 3 casos permaneceram em estado vegetativo persistente. Com relação à etiologia: 31 (29,8%) dos casos foram devidos a meningoencefalite, 24 (23,1%) estado de mal epiléptico, 19 (18,3%) causa tóxico-metabólica, 16 (15,4%) hipertensão intracraniana, 7 (6,7%) choque/anóxia, 4 (3,8%) etiologia indeterminada, 3 (2,9%) miscelânea. Com relação à evolução das crianças, 23 (22,1%) foram a óbito, 32 (30,8%) evoluíram sem seqüelas, 39 (37,5%) tiveram alta com seqüelas neurológicas e10 (9,6%) não informado. CONCLUSÃO: De acordo com a análise do presente estudo conclui-se que cerca de um terço dos pacientes em coma agudo falece, um terço apresenta seqüelas neurológicas na alta hospitalar e um terço evoluim sem seqüelas.
19
Hossain, Md Anowar, and Hairul Azman Roslan. "Molecular Phylogeny and Predicted 3D Structure of Plantbeta-D-N-Acetylhexosaminidase." Scientific World Journal 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/186029.
Анотація:
beta-D-N-Acetylhexosaminidase, a family 20 glycosyl hydrolase, catalyzes the removal ofβ-1,4-linkedN-acetylhexosamine residues from oligosaccharides and their conjugates. We constructed phylogenetic tree ofβ-hexosaminidases to analyze the evolutionary history and predicted functions of plant hexosaminidases. Phylogenetic analysis reveals the complex history of evolution of plantβ-hexosaminidase that can be described by gene duplication events. The 3D structure of tomatoβ-hexosaminidase (β-Hex-Sl) was predicted by homology modeling using 1now as a template. Structural conformity studies of the best fit model showed that more than 98% of the residues lie inside the favoured and allowed regions where only 0.9% lie in the unfavourable region. Predicted 3D structure contains 531 amino acids residues with glycosyl hydrolase20b domain-I and glycosyl hydrolase20 superfamily domain-II including the (β/α)8barrel in the central part. Theαandβcontents of the modeled structure were found to be 33.3% and 12.2%, respectively. Eleven amino acids were found to be involved in ligand-binding site; Asp(330) and Glu(331) could play important roles in enzyme-catalyzed reactions. The predicted model provides a structural framework that can act as a guide to develop a hypothesis forβ-Hex-Sl mutagenesis experiments for exploring the functions of this class of enzymes in plant kingdom.
20
Singh, Anurag, Shalini Rawat, Rashmi Kushwaha, Mili Jain, Shailendra Prasad Verma, Nishant Verma, and Uma Shankar Singh. "Bone Marrow Metastasis in Nonhematological Malignancies: A Study from Tertiary Care Center." Annals of African Medicine 23, no. 1 (2024): 91–99. http://dx.doi.org/10.4103/aam.aam_55_23.
Анотація:
Introduction: Metastatic cancer presents a treatment challenge to clinicians, particularly for patients with bone marrow infiltration. For tumor staging, therapy selection, and prognosis risk stratification, the status of the bone marrow should be known for the presence or absence of metastasis. The study aimed to evaluate the hematological findings and comprehensive analysis of bone marrow in cases of nonhematological malignancies with bone marrow metastasis. Materials and Methods: This retrospective study comprised a record retrieval of the departmental archives for the past 6 years. A total of 331 patients with nonhematological malignancies were found, of whom 31.42% (104/331) showed bone marrow metastasis. An integrated clinical approach with bone marrow examination findings and immunohistochemistry whenever necessary was used to achieve a definitive diagnosis of bone marrow metastasis. Results: Among the study population, 31.42% (104/331) of patients had nonhematological malignancies that metastasized to the bone marrow. Most of the patients with bone marrow metastasis had anemia, which was found in 77.88% (81/104) of the cases. Leukoerythroblastic reaction was noted in 31.73% (33/104) of the cases, and thrombocytopenia was found in 25% (26/104) of the cases. The most common malignancy with bone marrow metastasis in adults was prostatic adenocarcinoma (28.1%) (9/32) and in pediatric cases, neuroblastoma (53.9%) (52/98). Conclusions: It is essential to diagnose nonhematological malignancies that have metastasized to the bone marrow since this necessitates tumor staging, therapy selection, and prognosis risk stratification. To conclude, not a single hematological parameter is predictive of bone marrow metastasis; however, unexplained anemia, a leukoerythroblastic blood picture, and thrombocytopenia in peripheral blood should raise suspicion for bone marrow metastasis in cases of nonhematological malignancies.
21
Gorbachenko, О. F., F. I. Gorbachenko, V. D. Gorbachenko, Т. V. Usatenko, N. S. Luchkin, N. А. Zhitnik, and Е. G. Burlayeva. "Three-line hybrid of sunflower Nika." Oil Crops 3, no. 183 (November 30, 2020): 157–60. http://dx.doi.org/10.25230/2412-608x-2020-3-183-157-160.
Анотація:
A three-line sunflower hybrid Nika was developed by hybridization of a simple sterile hybrid Donskoy 59 and a line-restorer of pollen fertility ED 155 at the Don experimental station. It is characterized by high productivity, over the years of testing, it exceeded the control on seed yield by 0.25 t per ha, on oil collection per hectare by 0.16 t per ha. According to the length of the vegetative period (98–104 days), it can be attributed to the middle-early group. Plant height is up to 170–180 cm. The leaves are large, the bubbling is very weak, and serration is large. Heads of medium size when maturing turned down with a straight stem. Achenes are broadly ovate, black with grey stripes along the edges and between the edges. The main distinguishing feature of the hybrid is its high productivity and resistance to the new aggressive races of broomrape (E, F, G) and downy mildew (race 330). The hybrid Nika has been included into the State register of protected breeding achievements of the Russian Federation since 2019 and allowed to be cultivated in the Central Black Soil (5), Northern Caucasus (6), Middle Volga (7), Low Volga (8), Ural (9), and Western Siberian (10) regions of Russia.
22
Koca, Esra, Christine Koch, Gabriele Husmann, and Jörg Bojunga. "Time from first symptoms to diagnosis in GEP-NET patients: Results from a large German tertiary referral center." Journal of Clinical Oncology 38, no. 4_suppl (February 1, 2020): 610. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.610.
Анотація:
610 Background: Patients with neuroendocrine tumors (NET) often go through a long phase between onset of symptoms and initial diagnosis. Methods: Retrospective analysis of 486 patients with GEP-NET (488 tumors) at tertiary referral center from 1984-2019; inclusion criteria: Patients > 18 years, diagnosis of GEP-NET; descriptive analysis using SPSS; Cox regression, Log rank test. Results: Demographics: Male 54% / 52.9% (all/GEP-NET), median age at first diagnosis 63y/58y (all /GEP-NET). Localizations: small intestine 145/488 (29.7%), pancreas 143/488 (29.3%), CUP 53/488 (10.9%), colon 49/488 (10%), stomach 45/488 (9.2%), rectum 27/488 (5.5%), other digestive organs 11/488 (2.3%), esophagus 5/488 (1%), other 10/488 (2%). Ki67 in 330/488 (67.6%) evaluable patients: < 3%: 155/330; 46.9%; ≥ 3%: 111/330; 33.6%; > 20%: 64/330;19.3%. 128/488 (26.2%) of patients had NET specific symptoms (abdominal pain 77/128; 60.2%, diarrhea 51/128; 39.8%, flush 19/128; 14.8%, carcinoid syndrome 8/128; 6.3% tachycardia 6/128; 4.7%). 122/488 (25%) patients showed other tumor-specific symptoms (weight loss 48/122; 39.3%, stool irregularity 21/122; 17.2%, hypoglycemia 10/122; 8.2%, painless jaundice 8/122; 6.6%). 154/ 488 (32%) of NET were incidental findings (imaging 39.6%, endoscopy 23.4%, surgery for other causes 18.8%, appendectomy 15.6%). 221/279 (initial diagnosis/any time; 79.2%) patients had distant metastases at initial diagnosis (187/221 liver metastases). Time from tumor manifestation to initial diagnosis: pNET 360 ± 116 days, siNET 309 ± 87 days, gastric NET 66 ± 47 days, colonic NET 98 ± 67 days. Time from onset of symptoms to diagnosis in symptomatic patients was significantly longer than in asymptomatic patients (388 ± 86 days vs. 174 ± 58 days, p = 0.001). No significant difference in patients with or without distant metastases (223 ± 78 days vs. 259 ± 57 days, p = 0.355). Conclusions: A large proportion of NET are incidental findings and only about half of all patients are symptomatic at the time of diagnosis. Diagnosis for symptomatic patients takes significantly longer than for asymptomatic, which might be due to mainly unspecific symptoms. Presence of metastases has no influence on time to diagnosis.
23
Zagar, Robert John, William M. Grove, Kenneth G. Busch, John Russell Hughes, and Jack Arbit. "Looking Forward in Records of Young Adults who were Convicted of Homicide or Assault as Youth: Risks for Reoffending." Psychological Reports 104, no. 1 (February 2009): 129–54. http://dx.doi.org/10.2466/pr0.104.1.129-154.
Анотація:
To assess risks of violent offending in young adults, 425 Delinquent Assaulters ( M age = 14.1 yr., SD= 1.7; 77 girls, 348 boys) were matched with 425 Nonviolent Delinquents. Analysis of data from court, school, and medical records used Shao's bootstrapped logistic regressions. Predictors of Assaulter status were poorer executive function ( OR = 0.97) and prior court contacts for violent offenses ( OR = 3.5e+ 23; AUC=.97; 95% CI = .82−.99). Looking in records backward 4 years ( M = 4.1, SD = 2.6) and forward 10 years to mean age 24.5 yr. ( SD = 2.1), adults were classified as Homicidal (8%, n = 69); Delinquent Assaulters Later Adult Assaulters (10%, n = 86); Delinquent Assaulters Later Noncriminals (32%, n = 270); Nonviolent Delinquents Later Nonviolent Criminals (10%, n = 87); and Nonviolent Delinquents Later Noncriminals (40%, n = 338). The Homicidal group ( n = 69) was compared to matched Control and Nonviolent Delinquent groups ( n = 69) using logistic regression. Predictors of Homicidal versus Control were poorer executive function and alcohol or substance abuse ( AUC=.97; 95%CI =.93−.99). Predictors of Homicidal versus Nonviolent Delinquents were unemployment, poorer executive function, and prior court contacts ( AUC=.98; 95%CI=.95−.99).
24
Li, Ze, Jie-Ying Jing, Zhi-Qiang Qie, and Wen-Ying Li. "Influence of Reduction Temperature on the Structure and Naphthalene Hydrogenation Saturation Performance of Ni2P/Al2O3 Catalysts." Crystals 12, no. 3 (February 24, 2022): 318. http://dx.doi.org/10.3390/cryst12030318.
Анотація:
Jet fuel rich in hydroaromatics and cycloalkanes could be derived from direct coal liquefaction oil via the hydrogenation saturation process. Developing an efficient catalyst to transform naphthalene hydrocarbons to hydroaromatics and cycloalkanes with high selectivity plays a significant role in realizing the above hydrogenation saturation process. In this work, Ni2P/Al2O3 catalysts were prepared at different reduction temperatures via the thermal decomposition of hypophosphite. We investigated the influence of reduction temperature and the results showed that reduction temperature had an important impact on the properties of Ni2P/Al2O3 catalysts. When the reduction temperature was 400 °C, the Ni2P particle size of the Ni2P/Al2O3 catalyst was 3.8 nm and its specific surface area was 170 m2/g. Furthermore, the Ni2P/Al2O3 catalyst reduced at 400 °C obtained 98% naphthalene conversion and 98% decalin selectivity. The superior catalytic activity was attributed to the smaller Ni2P particle size, higher specific surface area and suitable acidity, which enhanced the adsorption of naphthalene on Ni2P/Al2O3 catalyst.
25
Adler, Limor, Moran Israel, Ilan Yehoshua, Joseph Azuri, Robert Hoffman, Arnon Shahar, Miri Mizrahi Reuveni, and Zachi Grossman. "Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study." BMJ Open 13, no. 2 (February 2023): e064155. http://dx.doi.org/10.1136/bmjopen-2022-064155.
Анотація:
ObjectivesTo estimate the prevalence of long COVID symptoms in children with and without a history of SARS-CoV-2 infection and to evaluate factors associated with long COVID.DesignA nationwide cross-sectional study.SettingPrimary care.Participants3240 parents of children aged 5–18 with and without SARS-CoV-2 infection completed an online questionnaire (11.9% response rate); 1148 and 2092 with/without a history of infection, respectively.Primary and secondary outcome measuresPrimary outcome was the prevalence of long COVID symptoms in children with/without a history of infection. Secondary outcomes were the factors associated with the presence of long COVID symptoms and with failure to return to baseline health status in children with a history of infection including gender, age, time from illness, symptomatic illness and vaccine status.ResultsMost long COVID symptoms were more prevalent in children with a history of SARS-CoV-2 infection: headaches (211 (18.4%) vs 114 (5.4%), p<0.001), weakness (173 (15.1%) vs 70 (3.3%), p<0.001), fatigue (141 (12.3%) vs 133 (6.4%), p<0.001) and abdominal pain (109 (9.5%) vs 79 (3.8%), p<0.001). Most long COVID symptoms in children with a history of SARS-CoV-2 infection were more prevalent in the older age group (12–18) compared with the younger age group (5–11). Some symptoms were more prevalent in children without a history of SARS-CoV-2 infection, including attention problems with school malfunctioning (225 (10.8%) vs 98 (8.5%), p=0.05), stress (190 (9.1%) vs 65 (5.7%), p<0.001), social problems (164 (7.8%) vs 32 (2.8%)) and weight changes (143 (6.8%) vs 43 (3.7%), p<0.001).ConclusionThis study suggests that the prevalence of long COVID symptoms in children with a history of SARS-CoV-2 infection might be higher and more prevalent in adolescents than in young children. Some of the symptoms, mainly somatic symptoms, were more prevalent in children without a history of SARS-CoV-2 infection, highlighting the impact of the pandemic itself rather than the infection.
26
Nießen, Anna, Fabiola A. Bechtiger, Ulf Hinz, Magdalena Lewosinska, Franck Billmann, Thilo Hackert, Markus W. Büchler, and Simon Schimmack. "Enucleation Is a Feasible Procedure for Well-Differentiated pNEN—A Matched Pair Analysis." Cancers 14, no. 10 (May 23, 2022): 2570. http://dx.doi.org/10.3390/cancers14102570.
Анотація:
The extent of surgical resection in the treatment of pancreatic neuroendocrine neoplasms (pNEN) is still controversial. This study aimed to evaluate the outcomes of enucleation for well-differentiated non-functional (nf) pNEN. Patients undergoing enucleation (2001–2020) were analyzed. Clinicopathological parameters, perioperative outcomes and survival were assessed. The analysis was performed as a nested case-control study and matched-pair analysis with formal resection. Sixty-one patients undergoing enucleation were identified. Compared to patients undergoing formal resection, enucleation was associated with a significantly shorter median length of operative time (128 (IQR 95–170) versus 263 (172–337) minutes, p < 0.0001) and a significantly lower rate of postoperative diabetes (2% versus 21%, p = 0.0020). There was no significant difference in postoperative pancreatic fistula rate (18% versus 16% type B/C, p = 1.0), Clavien−Dindo ≥ III complications (20% versus 26%, p = 0.5189), readmission rate (12% versus 15%, p = 0.6022) or length of hospital stay (8 (7–11) versus 10 (8–17) days, p = 0.0652). There was no 30-day mortality after enucleation compared to 1.6% (n = 1) after formal resection. 10-year overall survival (OS) and disease-free survival (DFS) was similar between the two groups (OS: 89% versus 77%, p = 0.2756; DFS: 98% versus 91%, p = 0.0873). Enucleation presents a safe surgical approach for well-differentiated nf-pNEN with good long-term outcomes for selected patients.
27
Beuaars, Paul R., Remmelt Van Duk, Jos A. M. Geertsen та Hans Nootenboom. "Determination of Long-Life Radiocesiums Cs-134 and Cs-137 in Food by γ-Ray Spectrometry: Summary of Collaborative Study". Journal of AOAC INTERNATIONAL 80, № 3 (1 травня 1997): 545–48. http://dx.doi.org/10.1093/jaoac/80.3.545.
Анотація:
Abstract A collaborative study was conducted to validate a γ- ray spectrometric method for determining cesium- 134 and cesium-137 in foods. The Cs-134 and Cs- 137 contents are measured with a low-resolution, shielded Tl-activated Nal scintillation detector connected to a multichannel γ-ray spectrometer. Thirteen laboratories participated in the study. Participants received 8 samples of heather honey, milk, and mixed dried herbs, including 4 blind duplicates. The accuracy of mean measurements of both isotopes was in the range of 98 to 103%, compared with reference measurements made in one laboratory using a high-resolution GeLi detector. Repeatability relative standard deviation (RSDΓ) values varied from 4.3 to 11.7% for 2 Cs-134 levels ranging from 121 to 337 Bq/kg and from 2.0 to 7.3% for 4 Cs-137 levels ranging from 210 to 1130 Bq/kg. Reproducibility relative standard deviation (RSDr) values ranged from 10.7 to 14.9% for Cs-134 and from 4.1 to 7.4% for Cs-137. No outliers were identified, and the method worked well in the absence of “fresh” fission products. However, the method was less appropriate for radiocesium determinations for activity concentration <100 Bq/kg at a counting time of 900 s or when Cs-137/Cs-134 activity ratio was larger than 10. The γ-ray method for determining Cs-134 and Cs-137 in foods has been adopted first action by AOAC INTERNATIONAL.
28
Winkler, Ira, Tatjana Heisinger, Marlene Hammerl, Eva Huber, Martina Urbanek, Ursula Kiechl-Kohlendorfer, Elke Griesmaier, and Anna Posod. "MicroRNA Expression Profiles as Diagnostic and Prognostic Biomarkers of Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy." Neonatology 119, no. 2 (2022): 204–13. http://dx.doi.org/10.1159/000521356.
Анотація:
<b><i>Introduction:</i></b> Perinatal asphyxia is a leading cause of neonatal death. Up to one-third of asphyxiated neonates suffer from hypoxic-ischaemic encephalopathy (HIE) with substantial long-term morbidity. Currently available diagnostic and prognostic tools bear limitations, and additional reliable biomarkers are needed for all stages of clinical management. A novel tool in neuroscientific research is micro-ribonucleic acid (miRNA) profiling. The aim of the present study was to determine miRNA expression profiles of healthy and asphyxiated neonates with and without HIE and to assess their potential as diagnostic and prognostic biomarkers. <b><i>Methods:</i></b> We prospectively enrolled 49 neonates with a gestational age of ≥36 weeks, 15 of which fulfilled the diagnostic criteria of perinatal asphyxia and 34 served as healthy controls. Dried blood spots were collected from umbilical cord blood (UCB) and from venous blood upon admission to neonatal intensive care unit (NICU) and at 48 h of life. Samples were analysed by means of FirePlex™ technology (Abcam, Cambridge, MA, USA). <b><i>Results:</i></b> In the UCB, miRNA expression levels of hsa-mir-124-3p, hsa-mir-1285-5p, and hsa-mir-331-5p were significantly lower in asphyxiated neonates compared to healthy controls. Asphyxiated neonates requiring therapeutic hypothermia had significantly increased expression of hsa-miR-30e-5p and significantly decreased expression of hsa-miR-142-3p, hsa-miR-338-3p, hsa-miR-34b-3p, hsa-miR-497-5p, and hsa-miR-98-5p at the time of admission to the NICU. At 48 h, infants suffering from moderate/severe HIE with a poor long-term neurodevelopmental outcome showed a significant increase in hsa-mir-145-5p. <b><i>Discussion/Conclusion:</i></b> MiRNA profiling shows promise as a biomarker for perinatal asphyxia, hypothermia-requiring HIE, and poor neurodevelopmental outcome. Confirmatory studies are called for.
29
Malivanova, T. F., T. A. Astrelina, I. V. Kobzeva, V. A. Nikitina, Y. B. Suchkova, A. I. Golovkova, A. S. Ostashkin, et al. "Features of the Systemic Response to Adjuvant Radiation Therapy in Carriers of Polymorphism -308(G/A)TNF in Breast Cancer Patients." MEDICAL RADIOLOGY AND RADIATION SAFETY 68, no. 6 (December 2023): 92–98. http://dx.doi.org/10.33266/1024-6177-2023-68-6-92-98.
Анотація:
Background: Adjuvant radiation therapy (ART), an integral part of locoregional breast cance (BC) therapy, acting not only locally, but also systemically and leads to a shift in homeostasis, which is reflected in routine general clinical tests. Tumor necrosis factor (TNF) is a proinflammatory cytokine, the production of which can be influenced by the single-nucleotide substitution -308(G/A)TNF. The minor allele -308A can be included in the stable inherited haplotype AH8.1 of the HLA gene complex. At the same time, the carriage of the -308A without the AH8.1 haplotype is associated with a poor prognosis in patients with BC. The aim of the study was to evaluate the features of the systemic response to the course of ART in carriers of TNF-associated genotypes with BC. Material and methods: The sample is represented by 147 BC patients who underwent a course of ART (2 Gy in 25 fractions). Clinical and morphological characteristics and data of general clinical blood analysis were obtained from medical histories. Venous blood samples for the study were obtained at the beginning and at the end of the ART course. Alleles -308(G/A)TNF and marker alleles of haplotype AH8.1 (HLA-A×01, HLA-B×08 and HLA-DRB1×03) were determined by allele-specific PCR. sTNF concentrations were determined by the ELISA in 102 blood plasma samples. Results: TNF-associated comparison groups were identified based on genotyping: (1) 114 carriers -308GG of the TNF gene, regardless of the AH8.1 haplotype (77,6 %); (2) 23 carrier -308A(AH8.1pos) had at least one AH8.1 marker allele (15.6 %); (3) 10 carriers -308A(AH8.1neg) did not have any AH8.1 marker allele (6.8 %). In the -308A(AH8.1neg) group the average concentration of sTNF both at the beginning and at the end of ART was significantly higher and, unlike other comparison groups, did not significantly decrease at the end of the ART course. A significant decrease in absolute values was revealed during ART in a number of cases for leukocytes, platelets and lymphocytes, however within the reference values. In the group -308A(AH8.1neg) correlation analysis revealed a high strength of positive connections between sTNF and leukocytes (r=0.71; p=0.027), platelets (r=0.67; p=0.04), neutrophils (r=0.70; p=0.027) only at the end of ART, whereas at the beginning ART these correlations were weak (r≤0.3) and statistically unreliable. For other genetic groups, the revealed correlations were not strong enough. Conclusion: The revealed features of the systemic response to ART for carriers of a prognostically unfavorable genotype -308A(AH8.1neg) – a high concentration of sTNF and a positive correlation with the content of leukocytes (probably due to neutrophils) and platelets – can be considered as targets of individualized therapy.
30
Beuaars, Paul R., Remmelt van Duk, Jos A. M. Geertsen та Hans Nootenboom. "Determination of Long-Life Radiocesiums Cs-134 and Cs-137 in Food by γ-Ray Spectrometry: Interlaboratory Study". Journal of AOAC INTERNATIONAL 78, № 5 (1 вересня 1995): 1244–51. http://dx.doi.org/10.1093/jaoac/78.5.1244.
Анотація:
Abstract A gamma-ray spectrometric method for the determination of cesium-134 and cesium-137 in food was studied collaboratively in 13 laboratories, using 8 samples (including 4 blind duplicates) consisting of heather honey, milk, and mixed dried herbs. Low resolution, shielded Tl-activated Nal scintillation detectors were used to measure Cs-137 in the photon energy range 516 to 714 keV and Cs-134 in the range 716 to 880 keV. Results were generally acceptable and no outliers were identified for any sample results. The method worked well in the absence of “fresh” fission products. The method was less appropriate for radiocesium determinations where the activity concentration was <100 Bq/kg at a counting time of 900 s or where the Cs-137/Cs-134 activity-ratio was larger than 10. The accuracy of mean measurements of both isotopes (relative to reference measurements made in one laboratory using a high resolution GeLi detector) was in the range of 98 to 103%. For all samples analyzed, the repeatability relative standard deviation (RSDr) values varied from 4.3 to 11.7% for 2 Cs-134 levels ranging from 121 to 337 Bq/kg and from 2.0 to 7.3% for 4 Cs-137 levels ranging from 210 to 1130 Bq/kg, whereas the reproducibility relative standard deviation (RSDR) values for these levels ranged from 10.7 to 14.9% for Cs-134 and from 4.1 to 7.4% for Cs-137.
31
Shakya, Abhishesh, Sunil Chandra Jha, Ratna Mani Gajurel, Chandra Mani Poudel, Ravi Sahi, Hemant Shrestha, Surya Devkota, and Sanjeev Thapa. "Clinical characteristics, risk factors and angiographic profile of acute coronary syndrome patients in a tertiary care center of Nepal." Nepalese Heart Journal 16, no. 1 (April 30, 2019): 27–32. http://dx.doi.org/10.3126/njh.v16i1.23895.
Анотація:
Background and Aims: Acute coronary syndrome (ACS) refers to a group of clinical symptoms consistent with new onset or worsening ischemic symptoms. ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI) and unstable angina (UA) are the three types of ACS. The objectives were to study the risk factors prevalence, angiographic distribution and severity of coronary artery stenosis in ACS among patients admitted in Cardiology Department of Manmohan Cardiothoracic Vascular and Transplant Center (MCVTC).
Methods: This is a restrospective study of 419 ACS patients admitted and treated in MCVTC from November 2017 to October 2018. Patients were divided into STEMI, NSTEMI and UA then analyzed for various risk factors, angiographic patterns and severity of coronary artery disease.
Results: Mean age of presentation was 59.3Å}12.8 years. Majority were male 317(75.7%). Most patients had STEMI 252 (60.1%) followed by NSTEMI 98 (23.4%) and UA 69 (16.5 %). Risk factors: smoking was present in 241 (57.5%), hypertension in 212 (50.6%), diabetes in 144 (34.4%), dyslipidemia in 58 (13.8%). Single-vessel disease was present in 34.6 % patients, double- vessel disease was present in 27.44 % patients and triple vessel disease was present in 26.3 % patients, left main disease in 1.4 % patients. Normal coronaries were present in 6.4% patients and minor coronary artery disease in 3.8 % patients.
Conclusions: STEMI was the most common presentation. Three quarters of ACS were male patients. Smoking was most prevalent risk factor. Single vessel involvement was the most common CAG finding in all spectrum of ACS. Diabetic patients had more multivessel disease.
32
Permatasari, Resi, Latifa Aini Susumaningrum, Fahruddin Kurdi, and Achmad Ali Basri. "Progressive Muscle Relaxation Therapy in Hypertensive Elderly with Acute Pain." Jurnal Kesehatan Komunitas Indonesia 3, no. 3 (December 11, 2023): 326–39. http://dx.doi.org/10.58545/jkki.v3i3.79.
Анотація:
Hypertension is a major health problem that occurs in the elderly. The prevalence of hypertension increases with ageing. Pain is a problem that can be caused by several conditions, such as hypertension. Progressive muscle relaxation therapy can be used to lower blood pressure. This research aims to determine the application of progressive muscle relaxation therapy in the elderly who experience hypertension with acute pain nursing problems. This research uses a case report method that describes the case of Mrs A, who has acute pain nursing problems at Dahlia room, UPT PSTW Jember. Nursing care is provided comprehensively for three days with a duration of 15 minutes for each meeting. The results were obtained after being given nursing care with progressive muscle relaxation therapy interventions. Namely, there was a decrease in pain levels and complaints of pain with results on the first day pre-intervention blood pressure 150/100 mmHg post-intervention 140/90 mmHg, and pre-intervention pain complaints scale 5 NRS post-intervention 5 NRS. On the fifth day, the results of pre-intervention blood pressure were 140/90 mmHg, post-intervention 130/90 mmHg, and pre-intervention pain complaints 3 NRS, post-intervention 3 NRS. The average blood pressure for five days was pre-intervention 144/98 mmHg, post-intervention 134/90 mmHg, and pre-intervention pain complaints 4.2 NRS post-intervention 3.8 NRS. Progressive muscle relaxation therapy, which is carried out three times with a duration of 15 minutes, can have an effect on reducing blood pressure and reducing acute pain problems.
33
Matveeva, L. V., T. Ya Anikeeva, Yu V. Mochalova, and O. B. Stepanova. "The image of Russia in the consciousness of Russian youth: peculiarities of the value-semantic code of cultural representations." Psikhologicheskii zhurnal 42, no. 6 (December 2021): 99–110. http://dx.doi.org/10.31857/s020595920017076-9.
Анотація:
The study involved 98 representatives of Moscow youth; 116 of Perm youth and 104 of Tyumen youth. A total 318 respondents, 44% young men and 56% young girls, aged 18 to 25. The 49 bipolar psychosemantic scale of the study describes the image of the country in terms of its strength and authority in the international arena, activity in transformations and various aspects of assessment. Respondents evaluated the images of “Russia-country”, “Future Russia”, “USA”, “China”. The categorical structures of young people's social representations about the country's image, identified in all three regions, have three substantively comparable factors: 1) “Welfare, progressiveness of the country”, 2) “Level of social distance”, 3) “Civilizational attribution”. The value-semantic component in the structure of young people's ideas fixes the cultural codes of Russian civilization: “beauty”, “generosity”, “mercy”, “kindness”, “spirituality”, “morality”.
34
Driedger, Darcy R., and Peter Sporns. "Glycoalkaloid Concentration in Alberta Potatoes Determined by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry." Journal of AOAC INTERNATIONAL 82, no. 4 (July 1, 1999): 908–14. http://dx.doi.org/10.1093/jaoac/82.4.908.
Анотація:
Abstract Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry was used to determine concentrations of individual potato glycoalkaloids in tubers. Samples were extracted with methanol–water and deposited on 2,4,6-trihydroxyacetophenone crystals. Positive ions were analyzed with a MALDI time-of-flight mass spectrometer equipped with a 337 nm laser. Analyte ion intensities relative to an internal standard were used to determine chaconine and solanine concentrations. Calibration curves were prepared by standard additions to potato tuber material. The relative standard deviations (RSDs) of triplicate measurements ranged from 1 to 16%, with an average of 9%. The day-to-day RSD for replicate determinations was 11 %. Recoveries of analyst-prepared spikes (50 μg/g) averaged 104% for chaconine (RSD, 8%) and 98% for solanine (RSD, 4%). The method limit of detection was estimated to be 2 μg/g.
35
Mamani-Huanca, Amelia Cristina, Wilder Bustamante-Hoces, Manuel Alejandro Concha-Huarcaya, and Consuelo Gladys Rojas-Arce. "The Development of ICTS and Their Effect on the Academic Learning of Higher Education Students at a Public University." International Journal of Religion 5, no. 11 (June 25, 2024): 1756–62. http://dx.doi.org/10.61707/xzv8vf52.
Анотація:
The main objective of the scientific research article was to determine the development of ICTs and their effect on the academic learning of higher education students at a public university; for this purpose, a cross-sectional explanatory causal correlational study methodology was used, which was composed of a population of 335 students and as a sample 124 students were selected under a non-probabilistic sampling for convenience, through the use of ordinal logistic regression the results could be obtained which evidenced a sig.< 0.05 so it could be established under a Nagelkerke value of 0.980, The development of ICTs significantly affects 98% of the academic learning of higher education students, thus mentioning that the correct use and employment of information and communication technologies promote and enhance the academic learning that students perceive with a view to their pedagogical growth.
36
Tang, Binqing, Yingen Wu, Hong Fang, Yuqin Wu, and Kehua Shi. "Small RNA Sequencing Reveals Exosomal miRNAs Involved in the Treatment of Asthma by Scorpio and Centipede." BioMed Research International 2020 (January 16, 2020): 1–12. http://dx.doi.org/10.1155/2020/1061407.
Анотація:
Asthma is a common respiratory disease with inflammation in the lungs. Exosomes and microRNAs (miRNAs) play crucial role in inflammation, whereas the role of exosomal miRNA in asthma remains unknown. Here, we aimed to identify the key exosomal miRNAs and their underlying mechanisms involved in scorpio and centipede (SC) treatment in asthma. Eighteen mice were randomly divided into three groups: control group, asthma group, and SC treatment group. Effect of SC was assessed by hematoxylin-eosin staining and real-time PCR. Exosomes from asthma and SC treatment groups were analyzed by small RNA-seq. Results revealed SC significantly alleviated the pathogenesis of asthma and suppressed the release of inflammatory cytokines. A total of 328 exosomal miRNAs were differentially expressed between the exosomes from asthma and SC-treated mice, including 118 up- and 210 downregulated in SC-treated mice. The altered exosomal miRNAs were primarily involved in the function of transcription, apoptotic process, and cell adhesion; and pathway of calcium, Wnt, and MAPK signaling. Real-time PCR verified exosomal miR-147 was downregulated, while miR-98-5p and miR-10a-5p were upregulated in SC-treated mice compared to asthma mice. Moreover, the target genes of miR-147-3p, miR-98-5p, and miR-10a-5p were mainly enriched in Wnt and MAPK inflammatory signaling. miR-10a-5p promoted the proliferation of mouse lung epithelial cells and downregulated the expression of Nfat5 and Map2k6. These data suggest SC-induced exosomal miRNAs might mediate the inflammatory signaling and might be involved in the SC treatment in asthma. The exosomal miRNAs might be promising candidates for the treatment of asthma.
37
Yasin, SPd, M.Kes, Ade. "GAMBARAN ANGKA KEMATIAN BAYI DAN BALITA DI WILAYAH KABUPATEN TASIKMALAYA TAHUN 2014." JURNAL KESEHATAN BIDKESMAS RESPATI 2, no. 6 (August 13, 2015): 63–68. http://dx.doi.org/10.48186/bidkes.v2i6.57.
Анотація:
Diwilayah Kabupaten Tasikmalaya Angka Kematian Bayi pada tahun 2013 adalah 147 kasus per tahun. Dari 147 kasus, 98 kematian bayi dalam kandungan dan 49 pada proses melahirkan. Tujuan dari penelitian ini adalah mengetahui gambaran angka kematian bayi dan balita di wilayah Kabupaten Tasikmalaya tahun 2014.
Jenis penelitian yang digunakan adalah kuantitatif dengan metode deskriptif. Populasi dalam penelitian ini adalah bayi dan balita yang meninggal di wilayah Kabupaten Tasikmalaya Tahun 2014 yaitu 318 orang. Tehnik pengambilan sampel adalah dengan cara total sampling dimana semua populasi dijadikan sampel. Variabel dalam penelitian ini adalah jumlah angka kematian bayi dan balita, usia dan jenis kelamin. Analisis data dalam penelitian ini adalah analisis univariat. Analisis ini menghasilkan distribusi frekuensi untuk menggambarkan tiap-tiap variabel yang akan diteliti.
Hasil penelitian adalah Angka kematian bayi dan balita paling tinggi di Kabupaten Tasikmalaya tahun 2014 yaitu Kecamatan Cigalontang sebanyak 63 (19.81%), Mayoritas kematian berdasarkan usia mayoritas adalah kematian bayi yaitu 298 kasus atau 93.71%. serta Angka kematian bayi dan balita berdasarkan jenis kelamin mayoritas laki laki yaitu 205 (64.46%).
Diharapkan petugas kesehatan lebih meningkatkan pelayanan kesehatan ibu dan anak dengan menekankan pada upaya preventif melalui kegiatan penyuluhan, konseling serta penatalaksanaan pasien secara komprehensif.
38
Hoit, Brian D., Nancy Ball, and Richard A. Walsh. "Invasive hemodynamics and force-frequency relationships in open- versus closed-chest mice." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 5 (November 1, 1997): H2528—H2533. http://dx.doi.org/10.1152/ajpheart.1997.273.5.h2528.
Анотація:
We compared hemodynamics, ventricular function, and force-frequency relationships in six open-chest and six closed-chest anesthetized mice (FVB/N strain). Left ventricular (LV) pressure was measured with a 1.8- or 1.4-Fr Millar catheter placed via the right carotid artery and the LV apex in the closed- and open-chest state, respectively. Pacing was performed with electrodes placed either directly on atrial appendages (open chest) or with a 1-Fr bipolar catheter via the jugular vein (closed chest). Closed-chest animals had greater spontaneous heart rate (267 ± 106 vs. 147 ± 27 beats/min), LV systolic (81 ± 14 vs. 48 ± 9 mmHg) and diastolic pressures (11.2 ± 4.8 vs. 5.6 ± 2.4 mmHg), and maximal rise (+dP/d t max: 6,208 ± 2,519 vs. 3,682 ± 671 mmHg/s) and fall in pressure development (−dP/d t max: −6,094 ± 2,386 vs. −3,001 ± 399 mmHg/s). LV systolic pressure (98 ± 18 vs. 52 ± 11 mmHg), +dP/d t max (9,240 ± 2,459 vs. 5,777 ± 2,473 mmHg/s), and −dP/d t max(−8,375 ± 2,551 vs. −3,753 ± 1,170 mmHg/s) were significantly higher when animals were matched at a heart rate of 420 beats/min in closed-chest vs. open-chest animals. Biphasic force-frequency relationships were seen in all animals, but the critical heart rate was greater in the closed- than open-chest animals (432 ± 42 vs. 318 ± 42 beats/min). We conclude that 1) there are significant differences between invasive indexes of systolic and diastolic function between the closed- and open-chest preparations, 2) there is a biphasic force-frequency relationship in the anesthetized mouse, and 3) dP/d t max can be used to assess the cardiovascular phenotype.
39
Clark, Brenda G., Bryan V. Acton, Gwen Y. Alton, Ari R. Joffe, Irina A. Dinu, and Charlene M. T. Robertson. "Screening for language delay after life-saving therapies in term-born infants." Cardiology in the Young 26, no. 7 (December 28, 2015): 1343–51. http://dx.doi.org/10.1017/s1047951115002577.
Анотація:
AbstractBackgroundStrong recommendations have been made for the periodic developmental surveillance, screening, and evaluation of children with CHD. This supports similar calls for all at-risk children in order to provide timely, structured early developmental intervention that may improve outcomes. The aim of this study was to determine the accuracy of screening for language delay after life-saving therapies using the parent-completed vocabulary screen of the language Development Survey, by comparing screening with the individually administered language scores of the Bayley Scales of Infant and Toddler Development, Third edition.MethodIn total, 310 (92.5%) of 335 eligible term-born children, born between 2004 and 2011, receiving complex cardiac surgery, heart or liver transplantation, or extracorporeal membrane oxygenation in infancy, were assessed at 21.5 (2.8) months of age (lost, 25 (7.5%)), through developmental/rehabilitation centres at six sites as part of the Western Canadian Complex Pediatric Therapies Follow-up Group.ResultsVocabulary screening delay was defined as scores ⩽15th percentile. Language delay defined as scores >1 SD below the mean was calculated for language composite score, receptive and expressive communication scores of the Bayley-III. Delayed scores for the 310 children were as follows: vocabulary, 144 (46.5%); language composite, 125 (40.3%); receptive communication, 98 (31.6%); and expressive communication, 124 (40%). Sensitivity, specificity, positive predictive values, and negative predictive values of screened vocabulary delay for tested language composite delay were 79.2, 75.7, 68.8, and 84.3%, respectively.ConclusionHigh rates of language delay after life-saving therapies are concerning. Although the screening test appears to over-identify language delay relative to the tested Bayley-III, it may be a useful screening tool for early language development leading to earlier referral for intervention.
40
Shi, X., J. T. Potts, P. B. Raven, and B. H. Foresman. "Aortic-cardiac reflex during dynamic exercise." Journal of Applied Physiology 78, no. 4 (April 1, 1995): 1569–74. http://dx.doi.org/10.1152/jappl.1995.78.4.1569.
Анотація:
We investigated the aortic-cardiac reflex during low-intensity cycling in 10 healthy volunteers. Baroreflex function was assessed by the ratio of change in heart rate to mean arterial pressure (delta HR/delta MAP) during phenylephrine (PE) infusion. The ratio obtained during PE combined with low-level lower body negative pressure (LBNP) and calculated neck pressure (NP) was assessed as the gain of the aortic-cardiac reflex. Exercise (approximately 25% maximal O2 uptake or 25 +/- 2 W) significantly increased HR from 64 +/- 2 to 98 +/- 2 beats/min, MAP from 90 +/- 3 to 98 +/- 3 mmHg, cardiac output from 6.6 +/- 0.5 to 12.0 +/- 1.4 l/min, and O2 uptake from 3.8 +/- 0.2 to 10.4 +/- 0.6 ml.min-1.kg-1. However, delta MAP (+11.8 +/- 0.4 vs. + 11.3 +/- 0.8 mmHg), delta HR (-12.7 +/- 2 vs. -12.9 +/- 2 beats/min), and delta HR/delta MAP (1.10 +/- 0.19 vs. 1.15 +/- 0.15 beats.min-1.mmHg-1) were not statistically different between rest and exercise during PE. Although PE significantly increased central venous pressure in both supine rest (from 6.7 +/- 0.7 to 10.4 +/- 0.7 mmHg) and exercise (5.8 +/- 0.8 to 8.6 +/- 0.9 mmHg) conditions, when LBNP (-15 +/- 2 vs. -16 +/- 1 Torr for rest vs. exercise) was applied, both rest and exercise central venous pressures were returned to the preinfusion baseline values, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
41
Tanaka, Yoshiharu, and Nobuhiko Miwa. "Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches Together with Modulation of Skin Oiliness and Moisture." Hydrogen 3, no. 2 (April 1, 2022): 161–78. http://dx.doi.org/10.3390/hydrogen3020011.
Анотація:
Hydrogen-rich warm water (HW) has not been verified yet for skin anti-aging effects. Daily 10 min HW (dissolved hydrogen: 338–682 μg/mL, 41 °C) bathing and skin poultice with HW-impregnated towels for 11–98 days were demonstrated to improve wrinkle degrees (29 skin-loci) from 3.14 ± 0.52 to 1.52 ± 0.74 (p < 0.001) and blotch degrees (23 loci) from 3.48 ± 0.67 to 1.74 ± 0.92 (p < 0.001) in five healthy subjects (49–66 years old), by densito-/planimetrically evaluating with an Image-J software, and ranking into six hierarchies (0, 1–5). Meanwhile, skin oiliness was evaluated to increase for the oil-poor skins, but inversely decrease for excessively oily skins, suggesting the HW’s function as skin-oiliness modulation, with an appreciably negative correlation in prior oiliness contents versus change after HW application (r = −0.345, 23 loci). Skin moisture increased upon HW application, with a negative correlation (r = −0.090, 23 loci) in prior moisture contents versus post-HW-application moisture-changing rates, meaning that HW application compensated moisture for water-deficient skins (27.5–40% moisture), but not for wet skins (>41% moisture). Thus, the HW bath together with HW poultice exerted beneficial effects on skin appearances such as wrinkles, blotches and moisture/oiliness, some of which might ensue from enhanced antioxidant ability in blood, as was previously demonstrated for the HW bath.
42
Lemay, Jacinthe, Fatemah M. Alsaleh, Lulwa Al-Buresli, Mohammed Al-Mutairi, Eman A. Abahussain, and Tania Bayoud. "Reporting of Adverse Drug Reactions in Primary Care Settings in Kuwait: A Comparative Study of Physicians and Pharmacists." Medical Principles and Practice 27, no. 1 (2018): 30–38. http://dx.doi.org/10.1159/000487236.
Анотація:
Objective: To investigate and compare knowledge, attitudes, and practices regarding pharmacovigilance (PV) and the reporting of adverse drug reactions (ADR) among physicians and pharmacists in primary care settings. Subjects and Methods: A cross-sectional study was conducted, in which a validated self-administered questionnaire was distributed to 386 physicians and 197 pharmacists in 38 primary care clinics in Kuwait. Categorical variables were described using numbers and percentages. The Pearson χ2 test, Fisher exact test, and Mann-Whitney U test were used as appropriate. p < 0.05 was considered statistically significant. Results: Of the 583 questionnaires distributed, 485 were completed (by 318 physicians and 167 pharmacists), giving an overall response rate of 83.2%. A total of 52.8% (n = 256) and 70.5% (n = 341) of the study participants were knowledgeable about the definitions of PV and ADR, respectively, with pharmacists demonstrating significantly better knowledge of PV (n = 105/167 vs. 151/318, i.e., 62.9 vs. 47.5%; p < 0.001) and purpose (n = 123/167 vs. 177/318, i.e., 74.1 vs. 55.7%; p < 0.001). However, the majority (n = 434/485; 89.4%) were not aware of an ADR reporting system in Kuwait. Almost every participant (n = 474/485; 97.7%) thought it was necessary to report ADR. However, significantly fewer physicians than pharmacists (n = 248/318 vs. 147/167, i.e., 78.0 vs. 88.0%; p < 0.01) believed that ADR reporting was a professional obligation. Only 27.8% (n = 133/485) had reported ADR, with pharmacists having reported significantly fewer than physicians (n = 35/167 vs. 98/318, i.e., 21.7 vs. 30.8%; p = 0.036). Conclusions: This study indicated that the attitude was positive but there was suboptimal knowledge and poor practice among primary care physicians and pharmacists with regard to ADR reporting. Targeted training about ADR reporting while ensuring a robust regulatory framework would encourage ADR reporting practices in the primary health care setting in Kuwait.
43
Cheng, M. H., W. Y. Huang, and A. I. Lipsey. "Simultaneous liquid-chromatographic determination of prednisone and prednisolone in plasma." Clinical Chemistry 34, no. 9 (September 1, 1988): 1897–99. http://dx.doi.org/10.1093/clinchem/34.9.1897.
Анотація:
Abstract This high-performance liquid-chromatographic (HPLC) method for simultaneous determination of prednisone and its metabolite, prednisolone, in plasma is a modification of the method of Frey et al. (Clin Chem 1979;25:1944-7). Heparinized plasma (1.0 mL) with 0.1 mL of internal standard solution (11-deoxy-17-hydroxycorticosterone, 2 mg/L) is extracted with 7.0 mL of dichloromethane, then washed sequentially with 0.1 mol/L HCl, 0.1 mol/L NaOH, and deionized water, 2.0 mL each. The extract is evaporated and the residue reconstituted with 75 microL of mobile phase, methanol/H2O (40/60 by vol). Thirty microliters of this is injected onto a reversed-phase C6 column, which is eluted at 1.4 mL/min. Analytical recoveries of prednisone and prednisolone were 94-98% and 102-106%, respectively. Day-to-day precision (CV) was 3.8% for prednisone, 6.1% for prednisolone. We encountered no interference from the 21 other steroids and 25 drugs tested. This method is simple, accurate, and precise.
44
Hoorfar, J., A. Wedderkopp, and P. Lind. "Detection of antibodies to Salmonella lipopolysaccharide in muscle fluid from cattle." American Journal of Veterinary Research 58, no. 4 (April 1, 1997): 334–36. http://dx.doi.org/10.2460/ajvr.1997.58.04.334.
Анотація:
Abstract Objective To compare muscle fluid with serum samples for detection of antibodies to Salmonella lipopolysaccharide. Sample Population Muscle fluid and serum samples from 2 cattle populations: 1 from the island of Bornholm with no history of salmonellosis (n = 39), and the other from the S dublin-enzootic areas of Jutland (n = 144). Procedure Salmonella dublin (O:1,9,12), S typhimu-rium (O:1,4,5,12), and Salmonella O:9-blocking ELISA were used for testing the samples. Results In the S dublin ELISA, all serum and muscle fluid samples from cattle on the island of Bornholm had OD450 values well below the cutoff value (0.5). For samples obtained from cattle in the enzootic areas of Jutland, high correlation was found between serum and muscle fluid samples (rs = 0.89, P < 0.001). In addition, 19% (28/144) of the cattle had ELISA-positive muscle fluid and serum samples; 2% (3/144) had positive results for muscle fluid only, whereas 1 animal had positive results for serum only (κ = 0.91, P < 0.0001; sensitivity and specificity of 97%). The same samples had similar significant correlation in the S typhimurium ELISA (rs = 0.88, P < 0.001, κ = 0.7, P < 0.001; sensitivity of 73% and specificity of 98%) and the O:9-blocking ELISA (rs = 0.49, P < 0.001). Conclusion and Clinical Relevance Muscle fluid samples taken at slaughter can be used as a practical alternative to serum samples for surveillance of Salmonella infections in cattle. (Am J Vet Res I997;58;334-337)
45
Burger, Elise B., Shaktie A. Lalé, Steven E. R. Hovius, Christianne A. van Nieuwenhoven, and Sicco A. Bus. "Foot Function in Patients With Surgically Treated Preaxial Polydactyly of the Foot Compared With Age- and Sex-Matched Healthy Controls." Foot & Ankle International 40, no. 4 (December 20, 2018): 414–21. http://dx.doi.org/10.1177/1071100718816733.
Анотація:
Background: Treatment of preaxial foot polydactyly, a duplication of the first ray, consists of excision of an extra ray, aiming to improve shoe fitting and aesthetic appearance, while maintaining foot function. Currently, the effect of excision on foot function and foot-related patient experiences is unclear. Methods: A cross-sectional comparison between 37 children treated for preaxial foot polydactyly and 37 age- and sex-matched healthy controls was performed. Dynamic foot function was assessed using plantar pressure measurements and static foot characteristics by physical examination. Patient-reported outcomes for foot function and footwear were evaluated, using the Oxford Ankle Foot Questionnaire for Children (score, 0-100). Results: Compared with controls, patients had significantly lower median peak pressures at the hallux (148 kPa [IQR, 98-245] vs 272 kPa [IQR, 205-381], P < .001) and significantly higher peak pressures at the second metatarsal (217 kPa [IQR, 147-338] vs 166 kPa [IQR, 141-235], P = .002) and third to fifth metatarsals (214 kPa [IQR, 147-290] vs 161 kPa [IQR, 135-235], P < .001). Additionally, patients had a more medially deviated hallux, both while seated (15 degrees (IQR, 11-20) vs 12 degrees [IQR, 10-15], P = .001) and standing (20 degrees [IQR, 15-26] vs 18 degrees [IQR, 15-20], P = .001). No significant correlation between peak pressure distribution and hallux deviation was found. Patients reported minimal problems with foot function (87.5 [IQR, 64.6-100]), but distinct problems with footwear use (50.0 [IQR, 25.0-100]). Conclusion: Patients with surgically treated preaxial foot polydactyly had a substantially altered plantar pressure distribution with more lateral foot progression than healthy controls. Although an increased hallux deviation was not related to altered foot function, it seemed to be the reason for the patient-perceived problems with footwear. Level of Evidence: Level III, comparative series.
46
Köse, Şükran, Tuba Dal, Rıza Aytaç Çetinkaya, Oğuz Arı, Ercan Yenilmez, Esra Nurlu Temel, Emel Sesli Çetin, et al. "Molecular epidemiological investigation of carbapenem resistant Klebsiella pneumoniae isolated from intensive care unit patients of six geographical regions of Turkey." Journal of Infection in Developing Countries 17, no. 10 (October 31, 2023): 1446–51. http://dx.doi.org/10.3855/jidc.17651.
Анотація:
Introduction: Klebsiella pneumonia causes serious infections in hospitalized patients. In recent years, carbapenem-resistant infections increased in the world. The molecular epidemiological investigation of carbapenem-resistant K. pneumoniae isolates was aimed in this study. Methodology: Fifty carbapenem-resistant K. pneumoniae isolates from six geographical regions of Turkey between September 2019-2020 were included in the study. The disk diffusion method was used for the antibiotic susceptibility testing. The microdilution confirmed colistin susceptibility. Genetic diversity was investigated by MLST (Multi-Locus Sequence Typing). Results: The resistance rates were as follows: 49 (98%) for meropenem, 47 (94%) imipenem, 50 (100%) ertapenem, 30 (60%) colistin and amoxicillin-clavulanate, 49 (98%) ceftriaxone, 48 (96%) cefepime, 50 (100%) piperacillin-tazobactam, 47 (94%) ciprofloxacin, 40 (80%) amikacin, 37 (74%) gentamicin. An isolate resistant to colistin by disk diffusion was found as susceptible to microdilution. ST 2096 was the most common (n:16) sequence type by MLST. ST 101 (n:7), ST14 (n:6), ST 147 and ST 15 (n:4), ST391 (n:3), ST 377 and ST16 (n:2), ST22, ST 307, ST 985, ST 336, ST 345, and ST 3681 (n:1) were classified in other isolates. In İstanbul and Ankara ST2096 was common. Among Turkey isolates, the most common clonal complexes (CC) were CC14 (n:26) and CC11 (n = 7). Conclusions: In Turkey, a polyclonal population of CC14 throughout the country and inter-hospital spread were indicated. The use of molecular typing tools will highlight understanding the transmission dynamics.
47
Yang, Zhongfan. "Research on Dispatching Coordination Control Method of Distribution Network with Photovoltaic Power Generation." Journal of Physics: Conference Series 2592, no. 1 (September 1, 2023): 012096. http://dx.doi.org/10.1088/1742-6596/2592/1/012096.
Анотація:
Abstract The coordination control of photovoltaic power distribution networks faces challenges such as inaccurate load power prediction and long coordination times. To address these issues, this paper proposes a scheduling coordination control method for photovoltaic power distribution networks. The method involves analyzing the structure of the photovoltaic power generation system, obtaining the operation state of the network using disturbance observation methods, building a dispatching coordination control model, designing constraints for dispatching coordination control, building a power balance function, and solving the total demand power of the load. An algorithm flow is designed to optimize the coordination control of photovoltaic distribution networks. Experimental results demonstrate that the accuracy of photovoltaic unit power prediction using this method reaches 98%, with power grid dispatching and coordination control times always less than 3.8 seconds. This approach effectively improves the effectiveness of distribution network dispatching and coordination control.
48
Kim, Jin Seok, Ho Jin Shin, June-Won Cheong, Jong Wook Lee, Kyoo Hyung Lee, Deok-Hwan Yang, Won-Sik Lee, et al. "Statistical Correlations Between Quantifiable Disease Variables and Prognosis in Hematological Malignancy Patients Treated with Itraconazole as An Empirical Antifungal Therapy: A Prospective Multicenter Observational Study in Korea." Blood 112, no. 11 (November 16, 2008): 4028. http://dx.doi.org/10.1182/blood.v112.11.4028.4028.
Анотація:
Abstract We identified the clinical characteristics including disease status for expecting success outcome of empirical antifungal therapy for invasive fungal infection (IFI) using itraconazole in immunocompromised patients with hematological malignancies. The prospective multicenter observational study was performed at 26 medical centers for 9 months. Three hundred seventy six patients with hematological malignancies (median age 48) had been enrolled and analyzed. The patients with possible and probable categories for IFI according to the EORTC/MSG criteria were included. We excluded the patients with proven IFI. IV itraconazole was administered as routine schedule. Oral itraconazole solution was used after the IV itraconazole. Underlying disease consisted of 61% of AML and 15% of ALL. Overall success rate of empirical antifungal therapy with itraconazole was 196/376 (51%). Acute leukemia in non-CR status and advanced stage of MDS patients showed a lower trend of success rate. Combined co-morbidities, underlying lung disease, poor ECOG performance status (≥2), abnormal chest X-ray at the time of initiation of empirical antifungal therapy, no early initiation of empirical antifungal therapy (the duration of baseline neutropenic fever ≥3 days) and antifungal prophylaxis other than itraconazole were associated with decreased overall success rate. Multivariate analysis revealed that poor ECOG performance status (≥2) (P=0.01, HR = 1.90, 95% CI 1.17–3.06) and abnormal chest X-ray (P=0.02, HR = 2.00, 95% CI 1.12–3.58) were significantly associated with poor outcome of empirical antifungal therapy with itraconazole. Overall success rate of empirical antifungal therapy was not affected by antifungal prophylaxis. Defervescence in setting of neutropenia was 70% (264/276). Higher rate of defervescence was observed in the patients with early stage of MDS (92% vs. 40%, P = 0.02). Median time to defervescence after empirical itraconazole therapy was 3 days. Short mean time to defervescence was observed in the patients with acute leukemia in CR status (P = 0.002) or early stage of lymphoid malignancies (P = 0.03). Baseline fungal infections were diagnosed in 13 patients (3%). Of the patients with baseline fungal infections, 7 patients (54%) had a successful outcome. All 7 patients with successful outcome had baseline fungal infection with candidemia. The rate of breakthrough fungal infection was 4% (16/376). Breakthrough aspergillus infection was documented in the half of theses patients (8/16). The rate of breakthrough fungal infection also was not different according to the different disease status. Premature discontinuation of itraconazole therapy because of toxicity or lack of efficacy occurred in 35% (131/376). The proportion of patients who survived for at least 7 days after completion of itraconazole therapy was 90% (338/376). IV itraconazole followed by oral itraconazole solution is an effective regimen for empirical antifungal therapy in the haematological malignancy patients with persistent neutropenic fever. Poor performance status and abnormal chest X-ray were predictive factors for failure of empirical antifungal therapy with itraconazole in the patients with hematological malignancies. Table 1. Outcomes (overall success rate) according to the clinical characteristics Yes No P Co-morbidities 37/90 (41%) 156/286 (55%) 0.03 Diabetes mellitus 6/20 (30%) 187/356 (53%) 0.07 Lung disease 3/14 (21%) 190/362 (53%) 0.03 ECOG performance status -≥2 (vs. 0 or 1) 45/123 (37%) 148/253 (59%) < 0.001 Galactomannan test – positive 3/9 (33%) 33/74 (45%) 0.73 Abnormal chest X-ray 23/70 (33%) 156/278 (56%) 0.001 Abnormal chest CT 14/51 (28%) 5/8 (63%) 0.10 Duration of baseline neutropenia ≥7 days (vs. <7 days) 101/206 (49%) 92/170 (54%) 0.35 >10 days (vs. ≤10 days) 60/122 (49%) 133/254 (52%) 0.58 Duration of baseline neutropenic fever ≥3 days (vs. <3 days) 89/193 (46%) 104/183 (57%) 0.04 ≥5 days (vs. <5 days) 55/124 (44%) 138/252 (55%) 0.06 Antifungal prophylaxis 95/183 (52%) 98/193 (51%) 0.84 Other drugs (vs. itraconazole) 51/114 (45%) 44/69 (64%) 0.02
49
Rodriguez, Lisette Patricia, Vida Farhangi, Julaine Braham, Robert A. Smith, and Wilhelmine Wiese-Rometsch. "In-Hospital Glycemic Dysregulation Associated With Worse Outcomes in COVID-19." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A346. http://dx.doi.org/10.1210/jendso/bvab048.705.
Анотація:
Abstract Introduction: Evidence establishes that COVID-19 patients with DM2 are at increased risk for severe disease and worse outcomes. Peer reviewed data is sparse comparing glycemic control and clinical outcomes among COVID-19 patients with vs. without DM2, and thus we sought to address this gap. Methods: We selected patients at least 18 years old who expired or were discharged between March 16, 2020 through September 15, 2020. Principal analysis compared glycemic patterns among patients with DM2 vs. non-DM2. Median, coefficient of variation (CV), maximum and minimum glucose parameters were computed to characterize longitudinal glycemic patterns. Logistic regression modeling identified significant (p<.05) associations between composite outcome vs. glycemic parameters and putative risks for progression to severe COVID-19. Receiver operating characteristic (ROC) curve identified cut points for glycemic parameters. Cox regression models were employed to control for significant confounders. Continuous data summarized as median was compared using Kruskal-Wallis test. Discrete data were compared with Pearson’s chi-square test. Two-tailed p<.05 was significant. Results: Among 494 patients, 157 (32%) had DM2 with no intergroup differences in age (68 [56–79]), sex (52% male, 48% female), or race (68% Caucasian, 19% Other, 13% African American). Insulin was administered to DM2 (93%) and non-DM2 (54%) patients (p<.0001). Comorbidities were more prevalent in DM2, including cardiovascular (68% vs. 54%, p=.003), renal (72% vs. 52%, p<.0001) and obesity (51% vs. 38%, p<.0001). Markers including D-dimer (0.98 [0.61–1.95] mg/L), lactate dehydrogenase (308 [230–392] U/L), ferritin (436 [174–856] ng/mL), and triglycerides (172 [109–239] mg/dL), were not different in DM2 vs. non-DM2 (p>.05). CRP was greater in patients with (8.6 [3.6–14.6]) vs. without (6.1 [2.0–12.6]) DM2 (p=.005). Baseline glucose in DM2 (163 [121–253] mg/dL) vs. non-DM2 (107 [96–124] mg/dL) was significantly greater, with former an independent predictor of composite outcome (p=.0005). Cox modeling of other glucose parameters in DM2 vs. non-DM2 demonstrated various impact regarding risk for composite outcome including median (155 [128–209], p=.46) vs. (103 [94–118], p=.09); coefficient of variation (28 [19–38], p=.08) vs. (15 [9–20], p=.002); maximum (252 [187–362], p=.0005) vs. (129 [110–156], p=.002); and minimum (99 [79–128], p=.95) vs. (89 [81–98], p=.02). The unified baseline glucose cut point for composite outcome risk controlled for significant covariates was 138 gm/dL (p<.0001), which included respectively 20% and 10% of patients with and without DM2. Conclusion: Glycemic dysregulation in COVID-19 patients is independently associated with ICU admission and/or hospital mortality. Presence of DM2 amplifies glycemic dysregulation, but risk stratification appears warranted in all COVID-19 patients.
50
Jairath, V., G. Zou, Z. Wang, S. Adsul, J. F. Colombel, G. R. D’Haens, M. Freire, et al. "P588 Interim results from the randomised VERDICT trial to determine the optimal treatment target in patients with ulcerative colitis." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i716—i717. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0718.
Анотація:
Abstract Background The optimal treatment target for ulcerative colitis (UC) is uncertain. The VERDICT trial in moderate to severe UC aims to determine if a treatment target of corticosteroid (CS)-free symptomatic + endoscopic + histologic remission is superior to CS-free symptomatic remission alone. Trial progress and the study cohort to date are described herein. Methods Our aim is to enrol 660 patients with moderately to severely active UC (Mayo rectal bleeding subscore [RBS] ≥1; Mayo endoscopic score [MES] ≥2). Patients are randomised to 3 treatment targets (2:3:5 ratio): CS-free symptomatic remission (Mayo RBS = 0) (Group 1); CS-free endoscopic remission (MES ≤1) + symptomatic remission (Group 2); or CS-free histologic remission (Geboes score <2B.0) + endoscopic + symptomatic remission (Group 3). Therapy is administered according to a treatment algorithm that is dependent upon each patient’s UC treatment at screening. Early introduction of vedolizumab (VDZ) and dose escalation up to 300 mg every 4 weeks until the target is met are central to each algorithm. Up to 3 opportunities to achieve the assigned target were prespecified in the algorithms (weeks 16, 32, or 48). Patients and central readers for endoscopy/histopathology are blinded to group allocation, and investigators are unblinded. Results As of 2 November 2022, 331 patients were enrolled at 55 sites across 10 North American and European countries. Mean (SD) baseline characteristics (Table) include a UC duration of 8.6 (8.3) years, Mayo Clinic score of 8.7 (1.7), C-reactive protein level of 13.3 (15.6) mg/dL, and a faecal calprotectin level of 1462.3 (1481.3) mg/kg. At baseline, 52% (172/331) and 11% (37/331) of patients were receiving concomitant CS and immunosuppressives, respectively, and 14% (47/331) had current/prior exposure to tumour necrosis factor antagonists. Most patients (85%) were receiving nonbiologic therapy. Of all randomised patients, 43/69 (Group 1), 65/98 (Group 2), and 115/164 patients (Group 3) have reached week 16; and 28 (65%), 25 (39%), and 42 (37%) met their target, respectively. After a median of 35 weeks (IQR 18-53), a total of 30 (Group 1), 32 (Group 2), and 50 patients (Group 3) have met their target and will be followed to relapse or study termination. The serious adverse event rate (8%; 36/483) was similar across groups. Conclusion VERDICT has randomised ~50% of its target enrolment. Enrolled patients represent a typical moderate to severe UC population and are primarily bionaive and receiving early VDZ initiation. Early results suggest the feasibility of achieving each treatment target, specifically histologic remission, and are consistent with expected values. No new VDZ safety signals were identified. Completion of enrolment is anticipated in late 2023.