Дисертації з теми "2RT"
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Arlauskas, Vilius, Mindaugas Bosas, and Laimonas Narbutas. "Ožinis 20t keliamosios galios kranas." Bachelor's thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120702_123644-18211.
Повний текст джерелаАнотація:
Baigiamojo darbo tema yra suprojektuoti 20 t. kieliamosios galios ožinį kraną. Variantų analizė buvo padaryta, važiuoklės pavarai, kravinių kėlimo mechanizmui ir krano tiltui. Technologinė analizė parodė, kokios įrangos reikia, pagaminti du velenus ir pirštą. Ožinio krano ekonominiai rodikliai, krano kaina ir jos galima pardavimo kaina buvo apskaičiuojama.The final paper’s theme is to design the gantry crane which load’s capacity is 20 tones. The variant analysis was done. It revealed that chassis gear, telpher, and beam were the most suitable parts for the gantry crane. The technological analysis showed what kind of equipment was needed in order to product two shafts and the girder. The gantry crane’s economical indicators, the crane’s cost price and its possible sale-price were calculated.
2
Pecháček, Michal. "Parní kotel na dřevní štěpku 25t/h, 5,5MPa, 475°C." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230874.
Повний текст джерелаАнотація:
The work deals with design of steam grate boiler with a output of 25 t/h, parameters of steam output p = 5.5 MPa, t = 475 °C and a temperature of feed water 105 °C. It is a boiler with natural water circulation by evaporation surfaces. Wood biomass is boiler fuel. The proposal consists of stoichiometric calculations, determination of boiler efficiency, thermal calculations and determinion geometric parameters of the boiler and its heat transfer surfaces. The boiler drawing is a part of the work.
3
Barzaj, Yasmin. "Conception d'une architecture hybride pour l'instrumentation et l'étude du comportement des 2RM." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS119.
Повний текст джерелаАнотація:
La thèse propose un système embarqué hybride pour l'acquisition de données. Le système se compose d'un "Smartphone" couplé à un micro-contrôleur de type MBED doté d'une interface bus CAN et d'une carte mémoire SD. Selon les besoins de la recherche,on peut ajouter des capteurs ad-hoc, installés sur le véhicule par exemple, en plus des capteurs présents dans les "smartphones" récents. Le postulat est que l'on peut bénéficier des capteurs présents dans les "Smartphones" pour réduire la complexité et le coût de l'instrumentation tout en obtenant une précision de mesure acceptable, et ainsi permettre un déploiement à large échelle du système d'instrumentation. Un tel instrument de mesure a pour objectif de permettre des applications variées dans le domaine des transports routiers (étude des comportements de conduite, contrôle des flux, ...). Une méthode a été implémentée pour identification des performances des capteurs embarqués dans divers smartphones. Des travaux ont été conduit pour la détection "en ligne" des défaillances de capteurs, et la reconnaissance "hors ligne" de manœuvres réalisées par le conducteur, l'objectif étant, à terme, de reconnaître automatiquement des manœuvres typiques telles que : la prise de virages, la prise de rond-points; les manœuvres d'évitementIn this thesis, we propose a new technic to identify a hybrid system for Data Acquisition,by using ad-hoc sensors on the vehicle, the sensors in the recent smartphones, MBED and CAN-BUS. The assumption is that the Smartphone's sensors will reduce the complexity and the high cost of these instrumentations. The objective is obtaining acceptable measurement accuracy of the collected trajectories and enable for a large-scale deployment of the system's instrumentation, such as a helpful system in the domain of transport. Weshow in this thesis how to build a hybrid system by depending on the properties of the used sensors in both the smartphones and in the vehicles to identify several situation like a failure sensor, accident situation and Rider's behaviour. This system is tested and evaluated on several real time on line - off- line including the used mode and method
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Ló, Rita de Cácia. "Atalia rainha de Judá - Leitura Exegética e Histórica de 2Rs 11,1-3.13-16." Universidade Metodista de São Paulo, 2006. http://tede.metodista.br/jspui/handle/tede/502.
Повний текст джерелаАнотація:
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Previous issue date: 2006-03-27Esta investigación pretende reconstruir um perído de la historia de Israel los seis años del govierno de la Reina Atalia, en Judea (841-836 aC). Teniendo como marco el análisis exegético e histórico del 2Rs11,1-3.13-16. El cenario y el estilo del 2Rs 11 nos permite afirmar que el autor pertencía al círculo de la escribas de la corte o de la institución religiosa. La investigación recurre a la particular ocurrencia de los términos reina madre y gebirah, presentes en el Antiguo Testamento, así como las contribuciones de las tradiciones de los países vecinos con el fin de explicar la ascensión de Atalia al trono de Judea. Atalia ejerció la función de reina madre; dentro de esta función tenía como compentencia la importante missón de cuidar de la realeza y eventualmente ejercer la regencia hasta que la ocupación por derecho y viabilizar su acción. Atalia gobernó durante seis años en Judea; para mantenerse tanto tiempo en el poder contó con las fuerzas aliadas es decir con un grupo que la afianzó en el trono. Atalia es hija de la casa de Omri su madre israelita de fe yavista. La partida de Atalia para Jerusalén es el resultado de un periodo de paz entre los dos reinos hermanos. La durabilidad de su gobierno se debe no a los actos de beligerancia y sí a su ejemplar administración basada principalmente en la actividad comercial favorecida por la posición estratégica de Jerusalén, siendo el puonto geográfico donde convergían impotantes rutas comerciles de la época. Atalia se emcontraba preparada para liderar un país cuya meta era el comercio internacional.
Esta pesquisa busca reconstruir um período da história de Israel os seis anos de governo da Rainha Atalia, em Judá (841-836 aC) tendo como base a análise exegética e histórica de 2Rs11,1-3.13-16. O cenário e o estilo de 2Rs 11 permitem afirmar que o autor pertencia ao círculo dos escribas da corte ou da instituição religiosa. A pesquisa recorre às ocorrências dos termos rainha-mãe e gebirah, presentes no Antigo Testamento, e às contribuições das tradições dos países vizinhos, a fim de explicar a ascensão de Atalia ao trono de Judá. Atalia ocupou a função de rainha-mãe. Com isso competia-lhe a importante função de cuidar da estabilidade da realeza e, eventualmente, exercer a regência até que a ocupação por direito se tornasse viável. Atalia foi soberana por seis anos em Judá. Para manter-se tanto tempo no poder, Atalia contou com forças aliadas, ou seja, um grupo que a garantiu no trono. Atalia é filha da casa de Omri com mãe israelita de fé javista. A vinda de Atalia para Jerusalém é resultado de um período de paz entre os dois reinos irmãos. A durabilidade de seu governo deve-se, não a atos de beligerância, e provavelmente sim à sua exemplar administração, baseada principalmente na atividade comercial, favorecida pela posição estratégica de Jerusalém no cruzamento de importantes rotas comerciais da época. Atalia estava preparada para liderar um país com metas no comércio internacional.
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Kulig, Gabriel, and Gustav Wallin. "R/2R DAC Nonlinearity Compensation." Thesis, Linköpings universitet, Elektroniksystem, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84481.
Повний текст джерелаАнотація:
The resistor ladder (R/2R) digital-to-analogue converter (DAC) architecture is often used in high performance audio solutions due to its low-noise performance. Even high-end R/2R DACs suffer from static nonlinearity distortions. It was suspected that compensating for these nonlinearities would be possible. It was also suspected that this could improve audio quality in audio systems using R/2R DACs for digital-to-analogue (A/D) conversion. Through the use of models of the resistor ladder architecture a way of characterizing and measuring the faults in the R/2R DAC was created. A compensation algorithm was developed in order to compensate for the nonlinearities. The performance of the algorithm was simulated and an implementation of it was evaluated using an audio evaluation instrument. The results presented show that it is possible to increase linearity in R/2R DACs by compensating for static nonlinearity distortions. The increase in linearity can be quite significant and audible for the trained ear.
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Stankevicins, Luiza da Cunha. "MicroRNAs in breast cancer progression and DNA damage response." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9187.
Повний текст джерелаАнотація:
Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorOs tumores de mama são caracterizados pela sua alta heterogeneidade. O câncer de mama é uma doença complexa, que possui o seu desenvolvimento fortemente influenciado por fatores ambientais, combinada a uma progressiva acumulação de mutações genéticas e desregulação epigenética de vias críticas. Alterações nos padrões de expressão gênica podem ser resultado de uma desregulação no controle de eventos epigenéticos, assim como, na regulação pós-transcricional pelo mecanismo de RNA de interferência endógeno via microRNA (miRNA). Estes eventos são capazes de levar à iniciação, à promoção e à manutenção da carcinogênese, como também ter implicações no desenvolvimento da resistência à terapia Os miRNAs formam uma classe de RNAs não codificantes, que durante os últimos anos surgiram como um dos principais reguladores da expressão gênica, através da sua capacidade de regular negativamente a atividade de RNAs mensageiros (RNAms) portadores de uma seqüencia parcialmente complementar. A importância da regulação mediada por miRNAs foi observada pela capacidade destas moléculas em regular uma vasta gama de processos biológicos incluindo a proliferação celular, diferenciação e a apoptose. Para avaliar a expressão de miRNAs durante a progressão tumoral, utilizamos como modelo experimental a série 21T que compreende 5 linhagens celulares originárias da mesma paciente diagnosticada com um tumor primário de mama do tipo ErbB2 e uma posterior metástase pulmonar. Essa série é composta pela linhagem obtida a partir do tecido normal 16N, pelas linhagens correspondentes ao carcinoma primário 21PT e 21NT e pelas linhagens obtidas um ano após o diagnóstico inicial, a partir da efusão pleural no sítio metastatico 21MT1 e 21MT2. O miRNAoma da série 21T revelou uma redução significativa nos níveis de miR-205 e nos níveis da proteina e-caderina e um enriquecimento do fator pró-metastático ZEB-1 nas células 21MT. Considerando a importância dos miRNAs na regulação da apoptose, e que a irradiação em diferentes espectros é comumente usada em procedimentos de diagnóstico como mamografia e na radioterapia, avaliamos a expressão de miRNAs após irradiação de alta e baixa energia e do tratamento doxorrubicina. Para os ensaios foram utilizados as linhagens não tumorais MCF-10A e HB-2 e as linhagens de carcinoma da mama MCF-7 e T-47D. Observou-se que raios-X de baixa energia são capazes de promover quebras na molécula do DNA e apoptose assim como, alterar sensivelmente miRNAs envolvidos nessas vias como o let-7a, miR-34a e miR-29b. No que diz respeito à resposta a danos genotóxicos, uma regulação positiva sobre a expressão de miR-29b, o qual em condições normais é regulado negativamente foi observada uma regulação positiva sobre miR-29b expressão após todos os tratamentos em células tumorais. Nossos resultados indicam que miR-29b é um possível biomarcador de estresse genotóxico e que miR-205 pode participar no potencial metastático das células 21T.
Breast tumors are characterized by their high heterogeneity. It is a complex disease, which has its development strongly influenced by environmental factors, combined with a progressive accumulation of genetic mutations and epigenetic dysregulation of critical pathways. Changes in gene expression patterns may be a result of a deregulation in epigenetic events as well as in post-transcriptional regulation driven by RNA interference endogenously represented by microRNA (miRNA) these mechanisms are capable to promote the initiation, maintenance and progression of carcinogenesis; they are also implicated on the development of therapy resistance. miRNAs form a class of non-coding RNAs which have emerged in recent years as one of the major regulators of gene expression through its capacity to silence messenger RNAs (mRNAs) containing a partially complementary sequence. The importance of regulation mediated by miRNAs was observed on their ability to regulate a wide range of biological processes including cell proliferation, differentiation and apoptosis.To gain insights into the mechanisms involved in breast cancer initiation and progression conducted a miRNA global expression on 21T series that are an in vitro model of breast cancer progression comprising cell lines derived from the same patient which include a normal epithelia (16N), primary in situ ductal carcinoma (21PT and 21NT) and cells derived from pleural effusion of lung metastasis (21MT-1 and 21MT-2). Considering the importance of miRNAs in the regulation of apoptosis, and that irradiation in different spectra is commonly used in diagnostic procedures as mammography and on radiotherapy, we evaluate the miRNA expression after cell low and high energy irradiation and doxorubicin treatment to determine whether miRNAs are useful biomarkers to detect cell response after DNA damage. The experiments were done on the non-tumoral cell lines MCF-10A and HB-2 and on the breast carcinoma derived cell lines MCF-7 and T-47D. We observed that of low energy X-rays is able to promote DNA strand breaks and apoptosis and to slightly change the expression of miRNAs involved on this pathway such as let-7a, miR-34a and miR-29b. Regarding DNA stress response pathways an upregulation on miR-29b expression, that in normal conditions is downregulated in tumor cell lines could be observed after all treatments. The microRNAome of 21T series revealed a significant downregulation of miR-205, an enrichment of the prometastatic factor ZEB-1, potential target for miR-205 and the consequent reduction of ecadherin levels in 21MT cells checked by western blot. Our results indicate that miR-29b is biomarkers of genotoxic stress and that miR-205can participate on the metastatic potential of 21T cells.
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Stark, Erik. "Kontraktsrättsliga regler och offentliga uppdrag - Närmare om att analogt tillämpa 36§ 2st. konsumenttjänstlagen på lantmäteriförrättningar." Thesis, Umeå universitet, Juridiska institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-132690.
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Němec, Radim. "Roštový kotel s přirozenou cirkulací na spalování slámy z pšenice,žita a ječmene,20t/h." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230887.
Повний текст джерелаАнотація:
The aim of this thesis is to propose a grate steam boiler for combustion of straw from wheat, rye and barley output of 20 t / h The calculation is performed by stoichiometric calculation of elemental analysis to calculate the dimensions of a boiler heating surfaces. Default superheated steam can be used mainly for electricity generation.
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Zhao, Haiyan. "Catalytic Hydrogenation and Hydrodesulfurization of Model Compounds." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/26526.
Повний текст джерелаАнотація:
This dissertation describes two related studies on hydrogenation and hydrodesulfurization of heterocyclic S-containing compounds.
Alkyl substituted thiophenes are promising candidates for hydrogen carriers as the dehydrogenation reactions are known to occur under mild conditions. Four types of catalysts including supported noble metals, bimetallic noble metals, transition metal phosphides and transition metal sulfides have been investigated for 2-methylthiophene (2MT) hydrogenation and ring opening. The major products were tetrahydro-2-methylthiophene (TH2MT), pentenes and pentane, with very little C5-thiols observed. The selectivity towards the desired product TH2MT follows the order: noble metals > bimetallics > phosphides > sulfides. The best hydrogenation catalyst was 2% Pt/Al2O3 which exhibited relatively high reactivity and selectivity towards TH2MT at moderate temperatures. Temperature-programmed desorption (TPD) of hydrogen indicated that the H2 desorption amount was inversely related to the rate of TH2MT formation. Temperature programmed reaction (TPR) experiments revealed that pentanethiol became the major product, especially with HDS catalysts like CoMoS/Al2O3 and WP/SiO2, which indicates that poisoned or modified conventional HDS catalysts would be good candidates for further 2MT hydrogenation studies.
The role of tetrahedral Ni(1) sites and square pyramidal Ni(2) sites in Ni2P hydrotreating catalysts was studied by substitution of Ni with Fe. The Fe component was deemed as a good probe because Ni2P and Fe2P adopt the same hexagonal crystal structure, yet Fe2P is completely inactive for hydrodesulfurization (HDS). For this purpose a series of NiFeP/SiO2 catalysts were prepared with different Ni:Fe molar ratios (1:0, 3:1, 1:1, 1:3, and 0:1) and investigated in the HDS of 4,6-dimethyldibenzothiophene at 300 and 340 oC. The uniformity of the NiFe series was demonstrated by x-ray diffraction analysis and by Fourier transform infrared (FTIR) spectroscopy of adsorbed CO. The position of substitution of Fe was determined by extended X-ray absorption fine structure (EXAFS) analysis. It was found that at 300 oC the HDS activity of the catalysts decreased with increasing Fe content and that this could be explained by the substitution of Fe at the more active Ni(2) sites. As temperature was raised to 340 oC, the activity of the Fe-containing samples increased, although not to the level of Ni2P, and this could be understood from a reconstruction of the NiFe phase to expose more Ni(2) sites. This was likely driven by the formation of surface Ni-S bonds, which could be observed by EXAFS in spent samples.Ph. D.
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Stout, Jesse. "Firearm Risk Regression Analysis for Law Enforcement Officer Firearm Usage Utilizing Factors in the M-Pulse and MMPI-2RF." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6951.
Повний текст джерелаАнотація:
The purpose of this quantitative study was to determine to what extent the 4 M-PULSE scale scores (interpersonal difficulties, unprofessional conduct, discharge of weapon, and inappropriate use of weapon) account for variance in the MMPI-2RF (aggression and antisocial) subscales scores. Archival data was provided by a private business that conducts these screenings for multiple law enforcement organizations (local and state). Law enforcement candidates (N = 127) were evaluated by a private business during the prehiring psychological screening process using the M-PULSE and MMPI-2RF to assess their risk factors for employment as law enforcement officers. Using Social Learning theory as the basis, the scores from the 2 measures were provided for regression analysis to determine what effect the M-PULSE factors had on the MMPI-2RF factors. This research did not find any significant effect on either MMPI-2RF factor by the 4 M-PULSE factors. This study adds to the growing body of knowledge of law enforcement psychological screening processes and how different measures provide critical information on personality, aggression, and risk factors that should be considered for individuals seeking employment in a law enforcement position. This study has implications for positive social change by increasing understanding of how current psychological screening processes determine suitability of candidates and help to ensure that individuals who would put the public and law enforcement organizations at higher risk should be screened out prior to completion of any law enforcement training.
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Cveček, Kristian. "Phasenerhaltende, rein optische 2R-Regeneration phasenkodierter Datensignale /." Erlangen : Scientific Press, 2009. http://d-nb.info/100033239X/34.
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Padda, Harwinder. "Noise modelling for 2R optical regenerator systems." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523653.
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DeDeo, Michelle Rose. "Graphs over the ring of integers modulo 2r /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9907598.
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Verrill, Robert William. "Positive energy representations of LσSU(2r) and orbifold fusion". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620268.
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Kaufmann, Thomas. "Synthese von (2R,2'R)-Di-O-isopropyliden-oscillol /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Barnes, Stéphanie. "[(IMes)2Pt(H)(Cl)]-Borabenzene Adducts : Synthesis and Reactivity of Complexes containing a Pt-Cl-B Interaction with Borabenzene." Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27843/27843.pdf.
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Ahmad, Khan Mumtaz. "A note on a polynomial set generated by G(2xt-t2) for the choice G(u)= oF1(--; a; u)." Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/97085.
Повний текст джерелаАнотація:
The present paper is a study of a class of polynomial set defined by means of a generating function of the form G(2xt- t²) for the choice G(u) = 0 F1(--;α;u). The paper contains some interesting results in the form of recurrence relations, generating functions, finite series of product of polynomials, hypergeometric form, relationship with Shively 's pseudo Laguerre and other polynomials, integral representation, fractional integral and Laplace transform of the polynomial.
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Hammerschmied, Clemens Maria. "CMOS A/D converters using MOSFET-only R-2R ladders /." Zürich, 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13921.
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Ishikawa, Yuki. "Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/IL-2Rγ-/- mice". Kyoto University, 2015. http://hdl.handle.net/2433/195963.
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Cheng, Zhenzhuang. "Total synthesis of (all-E,2R,6R)-2-(4-hydroxy-3-methyl-2-butenyl)-[epsilon,psi]-carotene;[(all-E,2R,6R)-7',8',11',12'-dehydrononaprenoxanthin] /." Bern : [s.n.], 1995. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Dinh, Kristie Nhi. "Interleukin-2 Receptor Alpha Nuclear Localization Impacts Vascular Smooth Muscle Cell Function and Phenotype." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1630243625985423.
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Sahraoui, Yasmina. "Étude structurale et fonctionnelle du récepteur de l'interleukine 2 (IL-2R) et implication du système IL2/IL-2R dans la prolifération cellulaire des leucémies aïgues lymphoblastiques T humaines." Paris 11, 1992. http://www.theses.fr/1992PA11T004.
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Al, Bayati Yashar. "Synthèse formelle de la L-Bioptérine à partir de l'acide tartrique." Rouen, 1989. http://www.theses.fr/1989ROUES048.
Повний текст джерелаАнотація:
La L-Bioptérine est un composé important qui intervient comme cofacteur d'enzymes dans de nombreuses réactions biologiques. Elle est généralement obtenue par condensation d'un sucre rare: le désoxy-5 L-arabinose avec la triamino-2,4,5 hydroxy-6 pyrimidine. Une nouvelle synthèse formelle de la L-Bioptérine est proposée à partir de l'acide tartrique. L'étape clef consiste en la préparation du diacétoxy-2r,3r ceto-4 pentanoate de méthyle ou de l'acide diacétoxy-2r,3r ceto-4 pentanoïque. Les composés sont obtenus par condensation d'organométalliques sur l'anhydride, le chlorure d'acide ou le thioester correspondant. La réduction en diacétoxy-2r,3s hydroxy-4 pentanoate de méthyle est réalisée sélectivement par NaBH4 ou mieux par Zn(BH4). Après lactomisation, la structure est déterminée par RMN 1H haut champ. L'accès au triacétyl-2,3,4 désoxy-5 arabinose est réalisé par application des méthodes décrites
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Giusti, Enrico. "Studio di fattibilità di motore bicilindrico in monocilindrico 2T per applicazioni aeronautiche." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7853/.
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Castillo, Liz Gabriela Gauto. "Rápida resposta para produção (2RP) : uma proposta de integração entre ferramentas da qualidade voltadas ao mapeamento das falhas em produtos no pós-venda." reponame:Repositório Institucional da UFPR, 2017. http://hdl.handle.net/1884/47489.
Повний текст джерелаАнотація:
Orientador : Prof. Dr. Fabiano Oscar DrozdaDissertação (mestrado) - Universidade Federal do Paraná, Setor de Tecnologia, Programa de Pós-Graduação em Engenharia de Produção. Defesa: Curitiba, 22/02/2017
Inclui referências : f. 113-118
Resumo: A presente dissertação visa contribuir para a área de diagnóstico de falhas em produtos de fabricação em massa após terem sido vendidos ao consumidor final. Para alcançar este objetivo, foi proposta a metodologia 2RP (Rapid Response For Production), a qual integra as seguintes ferramentas: Diagrama de Pareto, Diagrama de Afinidades, Diagrama FAST e Diagrama Matriz, sendo esta última auxiliada pela lógica difusa, a fim de superar as limitações ao pontuar as variáveis correlacionadas. Para validar a metodologia, foi feita uma aplicação em um caso prático, utilizando a base de dados da empresa Alpha, extraídas da plataforma virtual Reclame Aqui. Na primeira etapa, a metodologia serviu para identificar o produto e suas principais reclamações por meio do uso das ferramentas Diagramas de Pareto e Diagrama de Afinidade. Na segunda etapa, o produto foi caracterizado e classificado em suas funções básicas e secundárias, mediante o Diagrama FAST. Já na terceira etapa, utilizou-se o Diagrama Matriz para relacionar os principais problemas com os componentes que afetam o desempenho do produto para, assim, identificar os componentes que causaram a falha. Finalmente, o resultado obtido após a aplicação da metodologia 2RP permite que as empresas possam tomar ações para corrigir problemas de produção a fim de evitar reincidências de falhas e, consequentemente, de reclamações. Palavras-chave: Diagnóstico de Falhas, Metodologia híbrida, Técnicas de Qualidade, Lógica Difusa. Áreas de conhecimento: Engenharia de Produção; Engenharia da Qualidade
Abstract: The following master thesis aims to contribute to the area of diagnosis of failures in mass-produced products after being sold to the final consumer. To reach this objective, the Rapid Response For Production (2RP) methodology was proposed, which integrates the following tools: Pareto Diagram, Affinity Diagram, FAST Diagram and Matrix Diagram, this last tool being aided by diffuse logic to overcome the limitations when punctuating the correlated variables. Methodology validation was applied in a practical case, using the Alpha company database, extracted from the virtual platform Reclame Aqui. In the first step, the methodology served to identify the product and its main complaints through the use of the Pareto Diagrams and Affinity Diagram tools. In the second step, the product was characterized and classified in its essential and secondary functions, through the FAST Diagram. In the third step, the Matrix Diagram was used to relate the main problems with the components that affect the performance of the product to identify which ones caused the failure. Finally, the result obtained after applying the 2RP methodology allows companies to take actions to correct production problems to avoid recurrence of failures and, consequently, complaints. Keywords: Fault Diagnosis, Hybrid Methodology, Quality Techniques, Fuzzy Logic. Areas of expertise: Production Engineering; Quality Engineerin
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Liu, Ping Yi. "Réponse optique de InSb dans des conditions extrêmes de champ magnétique (B = 20T) et de température (T [égal ou inférieur à] 700 K)." Grenoble 1, 1991. http://www.theses.fr/1991GRE10165.
Повний текст джерелаАнотація:
Une etude originale de la structure de bande de insb intrinseque et de sa variation avec la temperature est effectuee en utilisant les techniques des hautes temperatures (300-700 k), du champ magnetique intense (0-20 t) et de l'optique dans l'infra-rouge et l'infra-rouge lointain. En suivant l'evolution de la reponse optique et magneto-optique avec la temperature, nous avons retrouve, dans le meme echantillon, pratiquement tous les principaux phenomenes etudies dans le passe mais uniquement aux temperatures inferieures a 300 k. Le changement de la structure de bande se manifeste dans la reponse optique et magneto-optique a travers le gap d'energie et la masse effective des electrons: ils sont fonction de la temperature et decroissent tous deux lorsque la temperature augmente
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Crouzet, Pierre-Elie. "Etude des propriétés d'un détecteur infrarouge H2RG pour l'optimisation d'un spectrographe embarqué sur le satellite SNAP/JDEM." Aix-Marseille 2, 2009. http://theses.univ-amu.fr.lama.univ-amu.fr/2009AIX22079.pdf.
Повний текст джерелаАнотація:
Le travail effectué pendant cette thèse s'inscrit dans le cadre de la mission SNAP (SuperNovae Acceleration Probe). Celle-ci propose de déterminer la nature de l'énergie Noire par la combinaison de mesures d'un échantillon de supernovae lointaines de type Ia avec des mesures de cisaillement gravitationnel. Le satellite embarquera deux instruments : un imageur grand champ et un spectrographe d'une précision photométrique et spectroscopique jamais atteinte. L'objectif de cette thèse est d'étudier les propriétés des détecteurs infrarouges hybrides H2RG (produit par Teledyne) du spectrographe pour optimiser ses performances. Pour cela, le détecteur H2RG numéro 40 a été caractérisé puis utilisé dans un prototype de spectrographe. Le mode de traitement des données a également été optimisé pour diminuer le bruit de lecture et détecter l'impact du rayonnement cosmique. Ces aspects seront développés dans cette thèse ainsi que leurs impacts sur les perormances du spectrographeThe SNAP (SuperNovae Acceleration Probe) mission is designed to measure very precisely the cosmological parameters and to determine the nature of the Dark energy. The mission is based on the measurement of some thousands supernovae of type Ia up a redshift of z=1. 7 and on weak gravitational lensing measurements of more than one thousand square degrees of the sky. The SNAP experiment consists in a 2-meter telescope with a one square-degree imager and an integral field spectrograph. We present in this thesis study on hybrid detector H2RG (produce by Teledyne) to improve performances of the SNAP spectrograph. The H2RG 40 detector was characterized and used in the spectrograph demonstrator. The way of sampling has been optimized to decrease the readnoise and detect cosmic ray and the impact on the spectrograph performances have been evaluated
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DURGARAJU, LAKSHMI CHAITANYA. "MODELING AND SIMULATION OF HIERARCHICALLY DECOMPOSED R-2R LADDER DAC USING VHDL-AMS." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1119885359.
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VOIRON, JEROME. "Developpement d'une methode d'imagerie spirale sur un aimant 2t. Application a l'imagerie spectroscopique." Université Louis Pasteur (Strasbourg) (1971-2008), 2000. http://www.theses.fr/2000STR13032.
Повний текст джерелаАнотація:
Les methodes d'imagerie rapide font actuellement l'objet de developpements importants dans la mesure ou elles sont devenues indispensables pour de nombreuses applications cliniques. Parmi les methodes d'imagerie rapide existantes, la methode d'imagerie spirale qui utilise des gradients oscillant pendant l'acquisition, n'a jusqu'a present que peu ete utilisee en imagerie clinique. Cette methode possede neanmoins un certain nombre de proprietes physiques interessantes qui la rendent avantageuse, comparee a l'imagerie echo planar traditionnellement utilisee en imagerie rapide, principalement pour les applications sensibles aux mouvements. L'obstacle majeur a une utilisation en routine est lie a la complexite de la structure de la methode d'imagerie spirale ainsi qu'aux difficultes techniques posees par l'application de gradients oscillant pendant l'acquisition. Cette these est une these de developpement methodologique qui a pour but la mise en uvre d'une methode d'imagerie spirale compatible avec les differents systemes d'acquisition bruker et facilement adaptable sur un ensemble de systemes de gradients bruker. Pour cela, nous avons tout d'abord realise une synthese bibliographique qui nous a permis d'adopter une strategie robuste, d'echantillonnage et de reconstruction des images spirales. Nous avons ensuite developpe un logiciel integrant l'ensemble des etapes d'acquisition et de reconstruction des images spirales, logiciel associe a la methode d'imagerie spirale implantee sous le logiciel d'exploitation paravision de bruker. Nous presentons egalement les resultats preliminaires obtenus lors de la phase de validation du logiciel sur objets tests et in vivo. Pour finir, nous avons applique le principe de l'imagerie spirale a l'imagerie spectroscopique, ce qui nous a permis de mettre en evidence les potentialites de notre logiciel et de notre methode d'imagerie spirale.
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Pham, Thu Ha. "Mécanisme d'action antidépresseur rapide de la kétamine et de son principal métabolite (2R,6R)-hydroxynorkétamine : rôle de la balance excitation-inhibition chez la souris." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS086/document.
Повний текст джерелаАнотація:
Selon l'OMS, les troubles dépressifs majeurs (TDM) seront la 2ème cause d'incapacité dans le monde en 2020 et deviendront la 1ère en 2030. Les antidépresseurs classiques ont des effets thérapeutiques retardés et de nombreux patients sont résistants. La kétamine, antagoniste du récepteur N-methyl-D-aspartate (R-NMDA) du L-glutamate, possède un effet antidépresseur rapide chez les patients résistants à un traitement classique. Le mécanisme de cette activité étonnante n'est pas bien compris. En couplant la microdialyse intracérébrale à un test comportemental prédictif d'une activité antidépressive dans un modèle de souris BALB/cJ de phénotype anxieux, nous montrons que cette activité de la kétamine dépend de la balance excitation-inhibition entre les systèmes glutamate/R-NMDA et R-AMPA, GABA/R-GABAA, sérotonine du circuit cortex préfrontal/noyau du raphé. Nos résultats suggèrent également que ce serait la combinaison [kétamine-(2R,6R)-hydroxynorkétamine, son principal métabolite cérébral] qui porterait l'effet antidépresseur. Mes travaux de thèse contribuent à une meilleure compréhension de l'effet rapide antidépresseur de la kétamineAccording to the WHO, major depressive disorder (MDD) will be the second leading cause of disability in the world in 2020 and will become the first in 2030. Conventional antidepressant drugs have delayed therapeutic effects and many patients are resistant. Ketamine, an N-methyl-D-aspartate (NMDA-R) receptor antagonist of L-glutamate, exerts a rapid antidepressant effect in patients who are resistant to standard therapy. The mechanism of this amazing activity is not well understood. By coupling intracerebral microdialysis to a predictive behavioral test of antidepressant activity in a BALB/cJ mouse model with an anxious phenotype, we show that this ketamine activity is dependent on the excitation-inhibition balance between glutamate/NMDA-R and AMPA-R, GABA/GABAA-R, serotonin systems in the prefrontal cortex/raphe nucleus circuit. Our results also suggest that it would be the combination [ketamine-(2R,6R)-hydroxynorketamine, its main brain metabolite] that would carry the antidepressant effect. My thesis work pave the way for the development of new fast-acting antidepressant drugs
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Prudent, Cécile. "Etude des psychoses dissociées : Approche clinique et projective comparées." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0069/document.
Повний текст джерелаАнотація:
La recherche que nous avons développée dans notre thèse a eu pour objectif l’étude des psychoses dissociées à travers une approche clinique et projective comparées. C’est à travers une révision de la littérature des psychoses, que nous avons, dans un premier temps, mis en évidence les diverses positions au sein de la nosographie psychiatrique dans un contexte historique, puis actuel. Nous avons croisé cette perspective à une approche issue de l’application du modèle métapsychologique, dont les jalons ont été posés par Freud (1911, 1920, 1924, 1940). En outre, nous avons mis en évidence une opposition entre Freud et Bleuler à travers leurs échanges épistolaires parus en 2016, et cela à propos de la question de l’autisme. La recherche que nous avons conduite est composée de plusieurs études. La première étude vise la comparaison statistique des indicateurs au test de Rorschach (Nina Rausch de Traubenberg, 1990) entre la population tout-venant ([n=310], (de) Tychey et al., 2012) et entre la population psychiatrique psychotique (n=81). Tous les diagnostics ont été réalisés en double aveugle au test de Rorschach et selon une double approche nosographique dans la clinique (psychanalytique et psychiatrique). La seconde étude est une analyse qualitative contrastée, constitué de 5 cas cliniques, consacrée à une investigation approfondie des psychés de cas cliniques exemplaires représentatifs des trois sous-groupes de référence de la population de l'étude. La troisième étude est longitudinale sur un cas clinique à 24 mois d’intervalles en test/re-test nous permettant de valider la fiabilité du diagnostic de paranoïa, dont nous assistons pourtant à l’évanouissement nosographique.Pour conclure, nous avons dégagé et validé l’indicateur de la représentation de soi intitulé : le degré de représentation de soi entière unitaire, qui permet notamment de discriminer les structures et les organisations entre elles. La psychose dissociée, reconnue pour représenter la faillite du narcissisme primaire est apparue comme une population adéquate au développement de ces travaux sur l’évaluation du narcissismeIt is thought a depth psychosis literature review, that we have, in a first time, highlighted various positions within the psychiatric nosography, in an historic and then, in a current context. We cross a perspective called objective to an approach more subjective, however very rewarding: the metapsychological model, whose milestones were thrown by Freud (1911, 1920, 1924, 1940). In addition, we highlighted an opposition between Freud and Bleuler thought their epistolary exchanges published in 2016 in French. This about, question of autism that Freud (1911) designated as well as a retreat of the libido on the Ego; contrarily to Bleuler (1911). To us, that epistemological and theoretical cleavages, have influenced the current nosography (DSM-5, A.P.A., 2013). The empirical research developed in this thesis, aimed at the study of dissociated psychosis through a clinical and projective compared approaches. Indeed, this research is composed by many studies: the first was aimed at the statistical comparisons of Rorschach’s indicators (Nina Rausch de Traubenberg, 1990) between non-clinical population ([n= 310], (de) Tychey et al., 2012) and clinical population, psychiatrist, and more specifically: psychosis dissociated ([in]patient [n= 81]). Within the first study, in a second time, we proceeded to the statistical comparisons between the three subgroups of the sample, constitute of: 25 subjects diagnosed with paranoia, 30 subjects diagnosed with schizophrenia and 26 diagnosed with paranoid schizophrenia. All diagnostics were realized in double bind et and according to a double approach (psychoanalytic and psychiatrist). The second study is a qualitative analysis contrasted, devoted to the deeply psychic investigation of exemplary clinical cases, representatively of three subgroups from the population’s study (paranoia; schizophrenia paranoid; pure schizophrenia). The sample is itself constituted of limits’ subgroups suffering from psychotic decompensations and hospitalized on a long court. In the qualitative study of clinical contrasted cases, we presented firstly, a subject from a pure paranoia structure: Catherine, an autopunitive feminine paranoia case.Secondly, we presented the analysis of a clinical picture from schizophrenic structure: Joseph, from which megalomaniac Ego and invasive delirium will surely arrested the lector; and finally, we analysed a pure schizophrenia case: Doug, which psychic desert particularly challenges us in conter-transferential’s dynamic. Then, to illustrated closer that we understand by sliding of an a-structure to a dissociated psychosis (and not to a melancholic proceed, as well as that is permitted by Bergeret [1974]), we analysed the cases of Jordan and Ali. Ali was initially inscribed in an a-structure (Bergeret, 1974), from which he decompensed secondarily in a paranoiac organisation; Jordan on other hands, decompensed secondarily in a pure schizophrenia
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Stankevicins, Luiza. "MicroRNAs in Breast Cancer Progression and DNA Damage Response." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T041.
Повний текст джерелаАнотація:
Le cancer du sein est marqué par une grande hétérogénéité. C´est une maladie complexe, fortement influencée par l´environnement pourtant, elle dépend aussi d´une accumulation de mutations génétiques associées à la dérégulation épigénétique des voies clés. Les altérations présentes dans le profil d´expression génique observées dans la tumeur, peuvent être le résultat de mécanismes de régulation des gènes à différent niveaux, comme des modifications post-transcriptionnelles menées par le mécanisme d´ARN d´interférence sous forme de microARN (miARN). Ce mécanisme peut conduire au début et développement du cancer aussi bien qu’à la résistance aux thérapies. Les miARN font partie d’une classe d´ARN non-codants qui ont émergé ces dernières années comme l'un des principaux régulateurs de l'expression des gènes par sa capacité à réguler négativement l'activité des ARN messagers (ARNm). L´importance de cette régulation a été observée par la présence de ce type de contrôle dans plusieurs processus biologiques, parmi eux, des voies liées à la prolifération, différentiation et apoptose. Afin de mieux comprendre les mécanismes d’initiation et progression tumorale dans le cancer du sein, nous avons fait une analyse globale de l´expression des miARN, par la technique de microarray, dans la série de lignées cellulaires 21T. Cette série est un modèle in vitro de la progression tumorale, comprenant la lignée 16N, obtenue à partir de l’épithélium normal infecté par des virus HPV-16, les lignées 21PT et 21NT, qui correspondent au carcinome in situ et les lignées 21MT1 et 21MT2 obtenues à partir d´une effusion pleurale métastatique à l’endroit de la métastase. Etant donné que les miARN jouent un rôle dans la régulation de l´apoptose et d´autres mécanismes de réponse aux dommages fait à l´ADN et que l´irradiation dans des formes différentes est couramment utilisée comme outil diagnostique, par exemple dans des mammographies, nous avons évalué l´expression de miARN après avoir soumis les cellules à des irradiations de haute et basse énergie, et au traitement avec de la doxorubicine. Les tests ont été faits sur les lignées non tumorales (MCF-10A et HB-2) et sur les lignées tumorales (MCF-7 et T-47D). On a pu observer que le rayon X de basse énergie est capable de causer des cassures double brin à l´ADN et de conduire les cellules à l´apoptose. Une légère altération dans les profils d´expression des miARN impliqués dans cette voie, comme let-7a, miR-34a et miR-29b, a aussi été remarquée. En ce qui concerne la réponse aux dommages fait à l´ADN, une upregulation dans l´expression de miR-29b, qui sous des conditions physiologiques normales est régulée négativement, a été observée après les traitements. Le microARNome de la série 21 montre une importante sous-expression de miR-205, un enrichissement du facteur pro-métastatique ZEB-1 et une réduction conséquente dans les niveaux d’e-cadherine, observée par western blot, seulement dans les lignées métastatiques (21MT). L´ensemble des résultats, suggèrent que miR-29b peut être un bio-marqueur potentiel du stress génotoxique et que miR-205 peut participer du processus de transition épithélium-mésenchyme et, en outre, quand il est sous-exprimé, peut augmenter le potentiel métastatique des cellules de la série 21TBreast tumors are characterized by their high heterogeneity. Breast cancer is a complex disease, which has its development strongly influenced by environmental factors, combined with a progressive accumulation of genetic mutations and epigenetic dysregulation of critical pathways. Changes in gene expression patterns may be a result of a deregulation in epigenetic events as well as in post-transcriptional regulation driven by RNA interference endogenously represented by microRNA (miRNA). These mechanisms are capable to promote the initiation, maintenance and progression of carcinogenesis and are also implicated on the development of therapy resistance. miRNAs form a class of non-coding RNAs, which have emerged in recent years as one of the major regulators of gene expression through its capacity to silence messenger RNAs (mRNAs) containing a partially complementary sequence. The importance of regulation mediated by miRNAs was observed on their ability to regulate a wide range of biological processes, including cell proliferation, differentiation and apoptosis.To gain insights into the mechanisms involved in breast cancer initiation and progression we conducted a miRNA global expression on 21T series that are an in vitro model of breast cancer progression, comprising cell lines derived from the same patient, which include a normal epithelia (16N), primary in situ ductal carcinoma (21PT and 21NT) and cells derived from pleural effusion of lung metastasis (21MT-1 and 21MT-2). Considering the importance of miRNAs in the regulation of apoptosis, and that irradiation in different spectra is commonly used in diagnostic procedures, as mammography and on radiotherapy, we evaluated the miRNA expression after cell low and high energy irradiation and doxorubicin treatment to determine whether miRNAs are useful biomarkers to detect cell response after DNA damage. The experiments were done on the non-tumoral cell lines MCF-10A and HB-2 and on the breast carcinoma derived cell lines MCF-7 and T-47D. We observed that low energy X-rays is able to promote DNA strand breaks and apoptosis and to slightly change the expression of miRNAs involved on this pathway, such as let-7a, miR-34a and miR-29b. Regarding DNA stress response pathways, an upregulation on miR-29b expression, that in normal conditions is downregulated in tumor cell lines could be observed after all treatments. The microRNAome of 21T series revealed a significant downregulation of miR-205, an enrichment of the pro-metastatic factor ZEB-1, potential target for miR-205 and the consequent reduction of e-cadherin levels in 21MT cells checked by western blot. Our results indicate that miR-29b is a possible biomarker of genotoxic stress and that miR-205 can participate on the metastatic potential of 21T cells
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Prachar, Christian [Verfasser]. "Untersuchungen zu Analytik und diagnostischem Nutzen von Interleukin-1 beta (IL-1β) und dem löslichen Interleukin-2-Rezeptor alpha (sIL-2Rα) beim Hund / Christian Prachar". Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1046735438/34.
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Singulani, Junya de Lacorte. "O papel da aldosterona no desenvolvimento das lesões tubulointersticiais em ratos hipertensos 2R-1C." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-03092013-150852/.
Повний текст джерелаАнотація:
A aldosterona participa da progressão das doenças renais em modelos experimentais e ensaios clínicos. Considerando que o modelo de hipertensão renovascular 2 rins-1 clipe (2R-1C) é caracterizado pela atividade elevada do sistema renina-angiotensina-aldosterona, o objetivo desse trabalho foi avaliar o papel da aldosterona na lesão renal presente nesse modelo através do bloqueio do receptor mineralocorticóide (RM) com espironolactona. Ratos Wistar foram submetidos ao procedimento cirúrgico para colocação de um clipe de prata na artéria renal esquerda e após 2 semanas do desenvolvimento da hipertensão renovascular 2R-1C, foram divididos em 3 grupos sendo que para o primeiro grupo nenhuma droga foi administrada (n=8), para o segundo grupo foi administrado por via oral 20 mg/Kg/dia de espironolactona (n=10) e para o terceiro, 7 mg/Kg/dia de amilorida (n=12). O peso e a pressão sistólica foram monitorados semanalmente. Coletas de urina (durante 24 h) e sangue foram realizadas em 3 períodos distintos: antes do procedimento cirúrgico; na 2° semana após a cirurgia (antes do início do tratamento) e na 6° semana após a cirurgia (após o término do tratamento). As amostras foram utilizadas para análise de creatinina, osmolalidade, sódio, potássio e albuminúria. Ao final do experimento, os rins foram perfundidos e pesados. Análise histológica para avaliar a extensão das alterações tubulointersticiais foi realizada. Além disso, marcadores de inflamação (ED-1 e p-JNK), de produção de matriz extracelular (fibronectina), de miofibroblastos (-actina de músculo liso) e de transdiferenciação tubular (vimentina) na região tubulointersticial cortical e de lesão nos podócitos (desmina) foram avaliados. O tratamento com espironolactona foi capaz de atenuar o aumento na excreção de albumina, o aumento na concentração plasmática de creatinina e a redução na depuração de creatinina. No rim clipado dos ratos 2R-1C, as lesões tubulointersticias e podocitárias, demonstradas pelos marcadores estudados, foram discretas e a terapia com espironolactona ou amilorida não foi capaz de minimizá-las. Por outro lado, no rim não clipado, a administração de espironolactona atenuou o aumento de matriz extracelular e a lesão nos podócitos. Os efeitos benéficos da espironolactona ocorreram independentes da redução na pressão sanguínea e podem ser em parte, dependentes do bloqueio do canal epitelial de sódio (ENaC). Tais efeitos trazem perspectiva para espironolactona como uma ferramenta terapêutica a ser explorada em pacientes com estenose de artéria renal.Aldosterone is involved in the progression of renal disease in experimental models and clinical trials. Considering that the model of renovascular hypertension 2 kidney-1 clip (2K-1C) is characterized by a high activity of the renin-angiotensin-aldosterone system, the objective of this study was to assess the role of aldosterone in renal injury in this model by blocking the mineralocorticoid receptor (MR) with spironolactone. Male Wistar rats were submitted to surgery to place a silver clip on the left renal artery and after two weeks of the development of 2K-1C renovascular hypertension they were divided into three groups. The first group was administered no drug (n=8), in the second group spironolactone 20 mg/kg/day was given orally (n=10) and the third group received amiloride 7 mg/kg/day (n=12). Body weight and systolic blood pressure were monitored weekly. Samples of urine (collected for 24 h) and blood were performed in 3 distinct periods: before surgery; 2 weeks after surgery (before treatment) and 6 weeks after surgery (after treatment). The samples were used to analyze creatinine, osmolality, sodium, potassium and albuminuria. At the end of the experiment, the kidneys were perfused and weighed. Histological analysis to assess the extent of tubulointerstitial changes was performed. Additionally, markers of inflammation (ED-1 and p-JNK), production of extracellular matrix (fibronectin), myofibroblasts (-smooth muscle actin) and tubular transdifferentiation (vimentin) in the area of tubulointerstitial cortical and injury in podocytes (desmin) were evaluated. Treatment with spironolactone was able to attenuate the increase in albumin excretion, the increase in plasma concentration of creatinine and the reduction in creatinine clearance. In the clipped kidney, tubulointerstitial and podocytes injuries, demonstrated by markers studied, were discrete and therapy with spironolactone or amiloride was not able to minimize them. However, in the non-clipped kidney, administration of spironolactone attenuated the increase of extracellular matrix and podocyte injury. The beneficial effects of spironolactone occurred independent of the reduction blood pressure and can be partly dependent of epithelial sodium channel (ENaC) blockade. These effects bring perspective to espironolactone as a therapeutic tool to be explored in patients with renal artery stenosis.
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Onkaraiah, Santhosh. "Modélisation et conception de circuits à base de mémoires non-volatiles résistives innovantes." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4759.
Повний текст джерелаАнотація:
Les limites rencontrées par les dernières générations de mémoires Flash et DRAM (Dynamic Random Access Memory) nécessitent la recherche de nouvelles variables physiques (autres que la charge et la tension), de nouveaux dispositifs ainsi que de nouvelles architectures de circuits. Plusieurs dispositifs à résistance variable sont très prometteurs. Parmi eux, les OxRRAMs (Oxide Resistive Random Access Memory) et les CBRAMs (Conductive Bridge Random Access Memory) sont de sérieux candidats pour la prochaine génération de mémoire dense. Ce travail se concentre donc sur le rôle des mémoires résistives (OxRRAM et CBRAM) dans les mémoires embarquées et plus particulièrement dans les FPGAs. Pour cela, nous avons développé un modèle compact, outil indispensable à la conception de circuits intégrés. Ensuite, nous avons conçus de nouveaux circuits non volatiles tels que des flips-flops (NVFF), des tables de correspondance (NVLUT), des commutateurs 2x2 ainsi que des SRAMs (NVSRAM). Ces structures ont finalement été simulées dans le cas d’un FPGA, afin de vérifier l’impact de celles-ci sur la surface, le délai ainsi que la puissance. Nous avons comparé les résultats pour un FPGA à base de NVLUTs utilisant une structure 1T-2R composée de CBRAMs par rapport à un FPGA plus classique utilisant des SRAMs. Nous réduisons ainsi la taille de 5%, la consommation de 18% et améliorons la vitesse de fonctionnement de 24%. La thèse aborde la modélisation compacte, la conception des circuits, et l’évaluation de systèmes incluant des mémoires résistivesThe grave challenges to future of traditional memories (flash and DRAM) at 1X nm regime has resulted in increased quest for new physical state variables (other than charge or voltage), new devices and architectures offering memory and logic functions beyond traditional transistors. Many thin film devices with resistance change phenomena have been extensively reported as ’promising candidates’. Among them, Ox- ide Resistive Memory (OxRRAM) and Conductive Bridge Resistive Memory (CBRAM) are leading contenders for the next generation high density memories. In this work, we focus on the role of Resistive Memories in embedded memories and their impact on FPGAs in particular. We begin with the discussion on the compact modeling of resistive memory devices for design enabling, we have designed novel circuits of non- volatile flip-flop (NVFF), non-volatile look-up table (NVLUT), non-volatile 2x2 switch and non-volatile SRAM (NVSRAM) using Resistive Memories. We simulated the impact of these design structures on the FPGA system assessing the performance parameters of area, delay and power. By using the novel 1T-2R memory element concept of CBRAMs in FPGAs to implement Look-up Tables (NVLUT), we would scale down the area impact by 5%, enhance speed by 24% and reduce the power by 18% compared to SRAM based FPGAs. The thesis addresses aspects of compact modeling, circuit design and system evaluation using resistive memories
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Avenell, Linda Claire. "The South Blackwater Reservoir analogue project." Thesis, Queensland University of Technology, 1998. https://eprints.qut.edu.au/107124/1/z%20T%28S%29%20284%20The%20South%20Blackwater%20Reservoir%20analogue%20project.pdf.
Повний текст джерелаАнотація:
The late Permian Rangal Coal Measures of the Bowen Basin, east central Queensland, have been the subject of a detailed investigation into floodbasin facies architecture in coalbearing environments. An extensive geophysical database, comprising well logs for over 230 boreholes and supplemented by core samples and excellent highwall exposures, has been used to determine the distribution of facies within interseam successions of the Kenmare Underground Mine, South Blackwater Coal Mine.
Maps of sedimentary facies, sand percent and interval thickness are presented for each of three sub-intervals within the Pollux (C) to Castor (B) interseam and a fourth interval between the Castor (B) and Aries (A) seams. These maps depict a small sub-basinal depression, 4 km x 2.75 km, and record accumulations of overbank and crevasse splay
sediments derived from a large channel network located outside the margins of the study area. The Lower Sub-Interval of the Pollux to Castor interseam records the early stages of elastic sedimentation, with numerous crevasse splay complexes and associated crevasse splay channels encroaching on distal floodbasin environments and shallow floodbasin lakes in the central part of the study area.
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Paludo, Ana Carolina. "Esporte e ansiedade pré-competitiva: uma análise dos parâmetros psicofisiológicos e sua relação com o desempenho esportivo em atletas profissionais de futsal." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/39/39133/tde-25112016-153047/.
Повний текст джерелаАнотація:
O estado de ansiedade pré-competitiva e seu possível relacionamento com o desempenho esportivo tem se tornado foco de investigação por diversos pesquisadores, principalmente na área da psicologia do esporte. Entretanto, na modalidade futsal, essa relação ainda encontra-se pouco explorada. Assim o objetivo geral do estudo foi verificar a relação entre ansiedade pré-competitiva e o desempenho esportivo em atletas profissionais de futsal durante os playoffs de um campeonato esportivo. Adicionalmente, buscou-se analisar a possível influência entre a condição de jogo (dentro e fora de casa) e fase do campeonato (quartas de final, semifinal e final) sob as respostas de ansiedade e desempenho, além de aplicar a Teoria da Catástrofe para testar a interação entre ansiedade, excitação fisiológica e desempenho. Para tanto o estudo analisou 16 atletas do sexo masculino de futsal, da categoria sub-20, pertencentes a um clube de elite, do estado de São Paulo, Brasil. O estudo foi conduzido durante os playoffs de um campeonato de alta importância para a equipe, sendo as coletadas realizadas nos jogos em casa e fora de casa, nas fases de quartas de final, semifinal e final. Em cada jogo, a coleta ocorreu entre 15 a 30min antes do aquecimento da equipe, sendo avaliados o estado de ansiedade pelo CSAI-2R e a excitação fisiológica pela VFC. O desempenho esportivo foi analisado subjetivamente pelo técnico (questionário em escala Likert). Os tratamentos estatísticos utilizados foram: ANOVA 2x3 para análise da influência da condição e fase do campeonato; a correlação de Pearson para analisar a correlação entre as variáveis analisadas e a regressão linear múltipla que compôs os cálculos da Teoria da Catástrofe. Para todas as análises, foram considerados um alfa de 5%. Como principais resultados destaca-se a relação positiva e significativa da excitação fisiológica e do desempenho entre as diferentes fases da competição. Correlações significativas foram estabelecidas entre as variáveis analisadas, entretanto a maioria delas classificadas como \"moderada\". Através da Teoria da Catástrofe foi possível observar uma positiva interação entre ansiedade, excitação fisiológica e desempenho esportivo. Através dos resultados encontrados, podemos concluir que: o estado de ansiedade pré-competitiva e o desempenho esportivo apresentam uma relação negativa em atletas de futsal. Esta relação pode ser observada com a aplicação da Teoria da Catástrofe, no qual sob altos níveis de ansiedade cognitiva, o desempenho do atleta de futsal tende a diminuir, apenas quando estado de excitação fisiológica estiver elevado. Podemos ainda concluir que a fase da competição pode influenciar significativamente no comportamento dos atletas, através de um aumento no nível de excitação fisiológica conjuntamente com um melhor desempenho com o passar das fasesThe pre-competitive state anxiety and it´s possible relationship with the sport performance has become a focus of investigation for many researchers, especially in sport psychology. However in the sport futsal, this relationship is still inconclusive. Thus, the aim of this study was to investigate the relationship between pre-competitive anxiety and performance of professional athletes of futsal during the playoffs of a championship. Furthermore, in this study the possible influence of the phase and game condition on the anxiety and performance responses was analyzed, additionally, the Catastrophe Theory was used to see the interaction amongst cognitive anxiety, arousal and performance responses. To develop this study, 16 male professional futsal athletes were analyzed, belonging to an elite club of São Paulo, Brazil. The study was conducted throughout the playoffs of an important championship on high level for the team. The samples were collected in home and away venue in phases of quarterfinals, semifinals and finals. The data were collected about 15 to 30 minutes before the warm-up in each game, in which the anxiety by CSAI-2R and the physiological arousal by HRV were evaluated. Performance was analyzed subjectively (Likert Scale questionnaire) and objectively (match analysis). The used statistics treatments were: the ANOVA 2x3 for analyzing the influence of phase and game condition; the Pearson\'s correlation for testing the correlation among the variables (state anxiety, physiological arousal and performance) and for the Catastrophe Theory followed specific statistical tests. For all analyzes the alpha was set on 5%. Among the main results we identified a significant influence of the phase of competition for the pre-competitive physiological arousal and the subjective performance. Significant correlations were found among the variables, however, the majority of them was classified as \"moderate\". The Catastrophe Theory presented a positive application on the interaction among anxiety, physiological arousal by HRV indices and performance. Concerning the findings, we can conclude that the pre-competitive state of anxiety and the performance showed a negative relationship in futsal athletes. This relationship can be observed in the Catastrophe Theory, when under high levels of cognitive anxiety, decrease their performance as a function of the increase of physiological arousal. Beyond that, we can conclude that the phase of the game can influence the athlete\'s behavior. When the phase of championship increases, the athletes show a higher level of physical arousal, plus the great subjective performance
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Harris, Joseph C. "An oncogenic role for gastrin and the CCK-2R in Barrett's oesophagus and oesophageal adenocarcinoma." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420337.
Повний текст джерела
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Öhlén, Peter. "Transmisison limitations of 2R reshaping repeaters and applications of high-speed wavelength conversion in optical networking." Doctoral thesis, KTH, Electronic Systems Design, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2992.
Повний текст джерела
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Krut, Sébastien. "Contribution à l'étude des robots parallèles légers, 3T-1R et 3T-2R, à forts débattements angulaires." Montpellier 2, 2003. http://www.theses.fr/2003MON20122.
Повний текст джерела
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Chaouch, Hacène Mahieddine. "Advanced Modulation Formats and All-Optical Processing Solutions for Future Fiber-Optic Communication Systems." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202987.
Повний текст джерелаАнотація:
In this dissertation we present the research findings around two important hot topics of modern and future fiber-optic communication systems: 100 Gbit/s transmission and alloptical processing of received phase-modulated signals. The findings are discussed in the same chronological order they were obtained. Each topic is summarized in two chapters that correspond to one selected journal and one conference publications. The first and second chapters are dedicated to the simulation and numerical analysis of 100 Gbit/s systems. In chapter one, we present a thorough investigation of the best 100 Gbit/s serial modulation format. Seven different modulation formats are considered and are compared in terms of tolerance to dispersion and maximum reach for a 10⁻⁹ bit error rate target. In chapter two, the behavior of chapter one’s best candidate is analyzed in a realistic environment. The influence of the existing lower data rate neighboring channels is discussed in particular. The results of these two chapters were obtained in collaboration with engineers from the Deutsche Telekom Technology Center in Darmstadt, Germany. They served as a theoretical basis for a field trial carried out by this same company. Chapter three and four focus on the use of semiconductor optical amplifiers for all-optical processing applications. Impaired phased-modulated signals are under particular interest in this study. The novelty in this work resides in the counter-propagating configuration that the semiconductor optical amplifier is operated in. In chapter three we give a detailed description of the experimental results. The complete setup is explained and the improvement in Q-factor and bit error rate for the received signal is proven. Furthermore, two novel concepts (Photonic Balancing and Saturated Asymmetric Filtering) that explain the observed improvements are developed and discussed for the first time to the best of our knowledge. Finally, chapter four aims at optimizing numerically the experimental setup for the saturated asymmetric filtering technique. The required detuned filter after the saturated semiconductor optical amplifier is optimized in terms of both off set and bandwidth.
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Junior, Gilson Costa dos Santos. "Estudo da cromatina nos sítios de fixação à matriz nuclear no domínio do gene TP53 e das modificações epigenéticas e no modelo de progressão tumoral mamária 21T." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7841.
Повний текст джерелаАнотація:
Conselho Nacional de Desenvolvimento Científico e TecnológicoDentre os diversos tipos de câncer agressivos, o câncer de mama é o mais comum em mulheres. Mutações hereditárias e adquiridas, assim como alterações epigenéticas atuam em sinergia na carcinogênese mamária e na progressão tumoral. A proteína P53 é uma supressora de tumor e possui uma atuação fundamental na integridade genômica. Apesar do vasto conhecimento sobre o controle da P53 a nível de proteína, ainda pouco se sabe sobre o controle transcricional do gene TP53. A série 21T, uma série de 4 linhagens celulares originadas da mama da mesma paciente, representando diferentes estágios de progressão tumoral mamária, é um eficiente modelo para investigação das alterações epigenéticas e suas influências na expressão gênica ao longo da progressão do câncer de mama. Nós analisamos a organização do domínio do gene TP53 através da técnica de arranjo de DNA, em diversas linhagens celulares de câncer de mama e linhagens controle, e realizamos uma tentativa de caracterizar estes elementos de DNA nas linhagens controle não-tumorais HB2 e MCF10A e nas tumorais MCF-7, MDA-MB-231, T47D, através dos marcadores epigenéticos de eucromatina, H4Ac, e heterocromatina, H3K9me3. Ainda analisamos a ligação de proteínas à região associada à matriz nuclear (MAR), denominada MAR 2, e a possível ligação da proteína ligante à matriz nuclear (MARBP), PARP-1, através de ensaios de gel shift (EMSA). Detectamos que na linhagem controle epitelial mamária, HB2, o gene TP53 está posicionado num domínio de DNA relativamente pequeno, aproximadamente 50 kb, delimitado por dois sítios de fixação à matriz nuclear. Interessantemente, esta estrutura de domínio se apresentou radicalmente diferente nas linhagens de câncer de mama estudadas, MCF7, T47D, MDA-MB-231 e BT474, nos quais o tamanho do domínio estudado estava aumentado e a transcrição do TP53 diminuída. Os enriquecimentos com os marcadores epigenéticos de cromatina H4Ac e H3K9me3 estão diferentemente distribuídos nas MARs nas linhagens celulares. Surpreendentemente, a MAR 2 apresentou uma ligação altamente específica, o que poderia representar a atuação de fatores transcricionais envolvidos na organização da cromatina. Através de programas de bioinformática, detectamos putativos sítios para interessantes fatores de transcrição, tais como o c/EBP-beta e c-myb, que poderiam atuar em cis regulando a expressão do gene TP53 e outros flanqueadores. Nós propusemos um modelo para a organização da cromatina na região de domínio do gene TP53 com os genes flanqueadores. Através da série 21T, detectamos uma hipometilação global genômica, nas células cancerosas 21NT e 21MT1. Uma importante diminuição da expressão global do marcador H4Ac nas células metastáticas 21MT1, foi detectada em relação às outras linhagens. Os níveis de RNAm das principais enzimas relacionadas as modificações epigenéticas são consistentes com as observadas hipometilação genômica e hipoacetilação. Através de microscopia confocal, verificamos que o marcador H4Ac está localizado, na maior parte na periferia e o marcador H3K9me3, pericêntrico nos núcleos tumorais. Por fim, verificamos que o promotor P1 do gene TP53 apresenta um estado de cromatina aberta, e a expressão do gene TP53 é similar em todas as células da série 21T.
Breast cancer is the most common aggressive cancer type in women. Inherited and acquired mutations as well as epigenetic alterations act together in breast carcinogenesis and tumor progression. P53 is a tumor suppressor protein critical for genome integrity. Although its control at the protein level is well known, the transcriptional regulation of the TP53 gene is still unclear. The 21T series, a series of 4 breast cell lines originating from the same patient and representative of the breast tumor progression stages, is a suitable model to investigate epigenetic alterations and their influences upon gene expression during breast tumor progression. We have analyzed the organization of the TP53 gene domain using DNA arrays in several breast cancer and control cell lines and we made an attempt to characterize these DNA elements in breast non-cancerous cell lines HB2 and MCF-10, and cancerous MCF-7, MDA-MB-231 and T47D, through the determination of epigenetic markers of euchromatin, H4Ac, and heterochromatin, H3K9me3. We further analyzed the matrix attachment region (MAR), named MAR 2, protein binding, and possible MAR 2 binding of the important MAR binding protein (MARBP), PARP-1, by Electrophoretic mobility Shift Assay (EMSA). We have found that in the control breast epithelial cell line, HB2, the TP53 gene is positioned within a relatively small DNA domain, encompassing 50 kb, delimited by two nuclear matrix attachment sites. Interestingly, this domain structure was found to be radically different in the studied breast cancer cell lines, MCF7, T47D, MDA-MB-231 and BT474, in which the domain size was increased and TP53 transcription was decreased. H4Ac and H3K9me3, chromatin epigenetic markers enrichment are differentially distributed through MARs in cell lines. Surprinsingly, MAR 2 presented a defined band-shift, which could represent trans-acting factor(s), involved in chromatin organization. By bioinformatics software, we found interesting transcription factors putative binding sites, such as for c/EBP-beta and c-myb, which could be cis-acting elements regulating TP53 and neighboring genes expression. We propose a model for the chromatin organization of the TP53 gene domain with neighboring genes. Through 21T cell line series, we detected a global genomic hypomethylation profile in the cancerous 21NT and 21MT1. An important global decrease of the active chromatin mark H4Ac in the metastatic 21MT1 relative to other cell lines was detected. mRNA levels of key enzymes linked to epigenetic modifications are consistent with the observed genomic hypomethylation and hypoacetylation. By confocal immunofluorescent assay we observed that H4Ac is mostly located at periphery, and the repressive mark H3K9Me3 located pericentric, in tumorigenic cells nuclei. TP53 P1 promoter in 21T series was found to be in an open state and TP53 transcription level was found to be similar in all 21T cell lines.
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Audran, Gérard. "Réactivité d'allysilanes isocycliques avec des électrophiles acétyléniques actives : synthèse énantiospécifique de la (+)-(2R,6R)-trans-γ-irone". Aix-Marseille 3, 1995. http://www.theses.fr/1995AIX30046.
Повний текст джерелаАнотація:
Ce travail est consacre a l'etude de la reactivite d'allylsilanes isocycliques avec des derives acetyleniques actives. La synthese enantiospecifique reussie de la (+)-(2r,6r)-trans-γ-irone en est l'aboutissement. Dans une premiere partie, nous rappelons brievement les differentes voies de synthese des allylsilanes et nous presentons le schema synthetique utilise pour preparer nos modeles. Dans une deuxieme partie, nous etudions la reactivite d'allylsilanes cyclopenteniques et cyclohexeniques avec la butynone. Cette etude nous a permis de conclure sur trois points principaux. -la chimioselectivite est completement differente pour une structure cyclopentanique ou cyclohexanique. Pour les cycles a 5 carbones, le produit majoritaire provient d'une cycloaddition 2+2 ; il est accompagne des produits de sakurai et de h-ene reaction. Dans le deuxieme cas, le compose de cycloaddition 2+2 est tres minoritaire ; la reaction s'ecoule dans le sens de la formation principale ou unique du produit de h-ene reaction. -l'encombrement sur le silicium n'est pas une condition obligatoirement necessaire a la suppression de la reaction de sakurai. -la regioselectivite de la h-ene reaction depend essentiellement de la structure du cycle. Pour la structure cyclopentanique, le produit est obtenu par arrachement de l'hydrogene en du groupe silyle (double liaison exocyclique). Inversement, pour la structure cyclohexanique, c'est l'hydrogene endocyclique qui est arrache preferentiellement (double liaison endocyclique). La formation de substrats provenant d'une cycloaddition 2+2 nous a conduit a etudier en addenda la reactivite des allylsilanes acycliques connus pour etre des entites de cycloaddition 3+2. Nous avons envisage la reaction du trimethylallylsilane et du triisopropylallylsilane avec des electrophiles acetyleniques actives (butynone et propiolate de methyle) en presence de differents acides de lewis. Nous avons toujours obtenu les produits de cycloaddition 2+2. Ces resultats nous permettent d'affirmer que la nature de l'acide de lewis employe ainsi que la structure du substrat silicie ont une influence preponderante sur le devenir de la reaction meme en serie acyclique. Dans une troisieme partie la reactivite particuliere des allylsilanes cycliques a 6 chainons a permis une nouvelle approche synthetique des (+-)-γ-ionone et (+-)-trans-γ-irone. L'utilisation de cette strategie en utilisant comme synthon chiral la (+)-(2r,5r)-trans-dihydrocarvone nous a permis de proposer une synthese enantiospecifique de la (+)-(2r,6r)-trans-γ-irone
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Zhukovskii, Rodion. "Vers un modèle numérique fiable du fonctionnement d'une torche de projection plasma à courant continu." Thesis, Limoges, 2020. http://www.theses.fr/2020LIMO0021.
Повний текст джерелаАнотація:
La projection plasma est une technologie de dépôt qui utilise un jet de plasma pour accélérer, chauffer, fondre et déposer des particules de poudre sur un substrat et ainsi, élaborer un revêtement. La reproductibilité du procédé dépend en grande part des fluctuations d’enthalpie et de vitesse du jet de plasma et de l’usure des électrodes. Les torches à plasma à anode cascadée permettent une longueur d’arc stabilisée et ainsi d’atteindre le premier objectif. Cependant, leur géométrie ne garantit pas l'absence d'érosion des électrodes. L’étude des processus électromagnétiques et thermiques à l'intérieur de la torche peut aider à contrôler les propriétés du jet de plasma et à réduire l’érosion des électrodes, et en particulier de l’anode. Ce travail porte sur la simulation d’une à plasma commerciale (la torche SinplexPro™ d’Oerlikon Metco) fonctionnant à l’argon sous pression atmosphérique. Il a été mené en deux étapes. La première a consisté à développer un modèle à l’équilibre thermodynamique local (ETL) du comportement dynamique de l’arc dans la torche. La tension d’arc et les pertes thermiques de la torche prédites par ce modèle sont est en bon accord avec celles mesurées pour un faible débit de gaz et un courant électrique élevé. Pour de telles conditions de fonctionnement, le modèle prédit un pied d’arc constricté à l’anode. Le modèle ETL a ensuite été utilisé pour tester deux méthodes pour faire tourner le pied d'arc sur la paroi de l'anode: une injection du gaz en vortex et un champ magnétique externe axial. L'injection du gaz avec un angle de 45° tourbillonnaire s'est avérée plus efficace qu’avec l’angle de 25° actuellement utilisé sur ce type de torche. La seconde étape de ce travail a consisté à développer un modèle à deux températures. Ce modèle considère deux formulations pour l’enthalpie des électrons et celle des espèces lourdes, qui différent par l'attribution de l'énergie d'ionisation à l’une ou l’autre des particules. Le modèle 2T avec les deux formulations prédit un pied d’arc diffus à l’anode et des tensions d’arc en bon accord avec les valeurs expérimentales pour une large plage de courant et de débit de gaz. Le mode diffus du pied d’arc anodique semble confirmé par l’observation d’anodes usées ayant fonctionné dans les mêmes conditions. La formulation de l’équation de l’énergie avec l’énergie d’ionisation assignée aux électrons a un coût de calcul acceptable et présente des résultats plus raisonnables en termes de température des électrons et des espèces lourdes. Cette formulation sera utilisée tive pour le développement ultérieur du modèle et son extension à des gaz diatomiquesDC plasma spraying is a coating technology that utilizes the energy of a plasma flow to accelerate, heat up, melt and deposit the coating powder on a substrate. For a high reproducibility in coating production, the plasma flow should have low fluctuations of enthalpy and velocity, and the erosion of electrodes should be limited. Plasma torches with a cascaded anode yield a more stabilized arc length and could achieve the first goal. However, a stabilized arc does not guarantee a low erosion rate of electrodes and in particular anode. An insight into the electromagnetic and thermal processes inside the plasma torch could help to control the properties of the plasma flow issuing from the torch and extend the lifetime of the torch parts. This work dealt with the simulation of the commercial plasma torch SinplexPro™ manufactured by Oerlikon Metco operated in argon under atmospheric pressure. It involved two steps. The first consisted in developing a LTE model with the inclusion of the electrodes in the computational domain. The arc voltage and cooling loss predicted by this model were in good agreement with the experimental values for a low gas flow rate and high electric current. For such operation conditions, the model predicted a constricted anode arc attachment. Then, two methods were tested to rotate the constricted anode arc attachment: gas swirling injection and axial external magnetic field. The swirling gas injection was found to be more efficient for a gas injection angle of 45° than for an angle of 25°, which is the angle used in the actual plasma torch. The second step of this study was about the development of a two-temperature model. The latter considered two formulations for the enthalpy of electrons and heavy species differing in the attribution of the ionization energy to electrons or heavy species. The 2T model with both formulations projected a diffuse anode arc attachment and arc voltage that agreed with the experimental values for a wider range of arc current and gas flow rate. The mode of anode arc attachment was confirmed by the observation of tested anodes. The formulation of the energy equation with the ionization energy assigned to the electrons had an acceptable computational cost and yielded reasonable results in terms of electron and heavy species temperature. It will be used to develop further the model and apply it to diatomic gases
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Gay, Mathilde. "Etude théorique et expérimentale de l'impact de la régénération 2R dans un système de transmission optique haut débit." Phd thesis, INSA de Rennes, 2006. http://tel.archives-ouvertes.fr/tel-00086500.
Повний текст джерелаАнотація:
Ce mémoire est consacré à l'étude de l'impact de la régénération 2R dans un système de transmission optique. La régénération optique 2R devrait permettre d'améliorer les performances et limiter le coût des liaisons longue distance et métropolitaines. Des dispositifs simples et peu coûteux pourraient en effet remplacer certains transpondeurs des liaisons optiques. Seules les techniques compatibles avec le réseau multiplexé en longueur d'onde (WDM) seront susceptibles de voir le jour. Ces travaux se sont par conséquent plus particulièrement tournés vers un dispositif 2R à base d'un absorbant saturable en microcavité verticale, dispositif qui présente les qualités requises pour l'application visée. Ces travaux ont donné lieu à des considérations tant d'un point de vue compréhension des phénomènes que d'un point de vue performances. Ils ont été réalisés dans le cadre du projet RNRT (Réseau National de Recherche en Télécommunications) ASTERIX (Absorbant Saturable pour la régénération TERabits multIpleXée en longueurs d'onde).Après une présentation des généralités sur les systèmes de transmission optique et des principales dégradations subies par le signal, nous abordons la régénération optique. Nous mettons ensuite en évidence la difficulté de démontrer l'efficacité d'un régénérateur. Nous montrons notamment que pour démontrer son efficacité, un régénérateur optique doit être caractérisé dans une liaison.
L'étude numérique et expérimentale d'une liaison comportant une cascade de régénérateurs optiques 3R, nous permet ensuite, dans le cas où l'accumulation de bruit d'amplitude limite la transmission, de connaître l'évolution des densités de probabilité depuissance des symboles et donc du taux d'erreur binaire (TEB).
Le cas d'une régénération 2R est ensuite abordé. Un dispositif original constitué d'un absorbant saturable suivi d'un amplificateur optique à semiconducteur (SOA) est caractérisé avant d'être cascadé dans une ligne de transmission à 10 Gbit/s. L'efficacitédu dispositif est démontrée puisqu'un facteur d'amélioration de la distance de propagation supérieur à 9,5 est obtenu pour un TEB de 10-8 permettant une propagation sur 20 000 km. L'accordabilité du dispositif est également démontrée sur une bande spectrale de 13 nm, ce qui est prometteur pour une transmission WDM.
Ce dispositif 2R nous permet finalement d'aborder de manière plus générale, l'effet d'une cascade de régénérateurs 2R dans une liaison. Une étude numérique clarifie le phénomène d'accumulation de gigue temporelle en présence de régénérateurs 2R. Une boucle à recirculation à pas de régénération variable permet d'étudier expérimentalemen l'impact du pas entre régénérateurs. Il existe un pas de régénération optimal correspondant au meilleur compromis entre accumulation de gigue temporelle et de bruit d'amplitude. L'étude met également en évidence l'intérêt d'espacer largement les régénérateurs (distance doublée pour 6 régénérateurs cascadés à un TEB de 10-8 dans le cas considéré). Enfin la limitation de la transmission par la gigue temporelle est mise en évidence expérimentalement.
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Ventura, Luciana Lima. "A confirmação da Conjectura de Artin para pares de formas aditivas de graus 2T.3 e 3T.2." reponame:Repositório Institucional da UnB, 2013. http://repositorio.unb.br/handle/10482/14101.
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Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Exatas, Departamento de Matemática, 2013.Submitted by Albânia Cézar de Melo (albania@bce.unb.br) on 2013-09-09T14:24:13Z No. of bitstreams: 1 2013_LucianaLimaVentura.pdf: 572550 bytes, checksum: 0ce7cf628a3d83b89a7518122378820d (MD5)
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Uma versão da Conjectura de Artin afirma que para um sistema homogêneo com duas equações diagonais de grau k, cujos coeficientes são inteiros, ter solução p-ádica não trivial é suficiente que o número de variáveis seja maior que 2 k2. Nesse trabalho, vamos mostrar que a conjectura é verdadeira quando o grau é 2T . 3 ou 3T . 2, para T≥ 2. ______________________________________________________________________________ ABSTRACT
One version of Artin's Conjecture states that for a homogeneous system with two diagonal equations of degree k, whose coe cients are integers, exists a nontrivial p-adic solution provided the number of variables is greater than 2 k2. In this paper, we show that the conjecture is true when the degree is 2T . 3 or 3T . 2, for T≥ 2.
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Cheng, Laurence Eng-Chee. "The contribution of IL-2R signals to the generation and maintenance of CD8⁺ T cell responses to antigen /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/8355.
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Gutiérrez, Moreno Susana Mónica. "Estudio de la bioadsorción de cadmio y plomo con biomasa de serratia marcescens m8a-2t, a nivel de laboratorio." Doctoral thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/4126.
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Las fuentes más comunes de contaminación ambiental son las refinerías de petróleo, plantas de generación de energía eléctrica, los procesos metalúrgicos y las plantas de tratamiento de efluentes cuyos desechos ingresan indirectamente a las aguas de los ríos, lagunas, océanos y suelos. Frente a este problema la biotecnología está tratando de presentar alternativas de bajo costo y fáciles de implementar, como la biodegradación de hidrocarburos, la remoción de metales pesados empleando desechos agroindustriales, organismos vivos de orígen animal, vegetal, microbiano, fúngico o algal, etc.
Con la finalidad de seleccionar una cepa que pueda servir como biosorbente microbiano, se reactivaron 122 cepas aisladas en ambiente minero, a las que se les probó la resistencia a metales pesados, velocidad de crecimiento y capacidad de producción de biomasa. En base a estos parámetros se seleccionó la cepa de Serratia marcescens M8A-2T para optimizar los parámetros físico químicos de remoción de cadmio y plomo, la naturaleza física y genética de la resistencia así como la confirmación de la identificación de la cepa empleando el gen del RNAr 16S.
Se obtuvieron 27 cepas resistentes a metales pesados; 2 cepas resistieron hasta 80000 ppm de zinc, 20 cepas a 16 000 ppm de níquel, 1 cepa a 36 000 ppm de cromo, 23 cepas a 800 ppm de cadmio y 80 cepas a 32 000 ppm de plomo. S. marcescens no presentó plásmidos en la electroforesis en gel de agarosa y en la microscopía electrónica de transmisión se pudo observar que el metal se adhería
a la superficie bacteriana, por lo tanto el proceso de remoción es de bioadsorción.
La biomasa logró remover 99,97 % de cadmio a pH 3 y 96 % de plomo a pH 7, despues de 60 minutos de enfrentamiento con 100 ppm de cada uno de los metales. La remoción fue independiente de la concentración inicial de metal y operó muy bien con biomasa de granulometría menor a 50 μm y 1 mg/ml de concentración.
Para conocer la máxima capacidad de retención (Qmax) se usaron las isotermas de Langmuir resultando que la cepa en estudio tiene un Qmax de 417 mg de cadmio / g y de 357 mg de plomo / g , en 15 minutos, y se ajustó en 98,3 % al modelo de Langmuir.
Estos resultados, indican que la cepa es apta para ser empleada en procesos de bioadsorción de cadmio y plomo y que el proceso está optimizado para su escalamiento a nivel piloto.Tesis
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Kennedy, Michael James. "Natural and enhanced wood durability from pine heartwood phenolics." Thesis, Queensland University of Technology, 1996. https://eprints.qut.edu.au/107122/1/z%20T%28S%29%20108%20Natural%20and%20enhanced%20wood%20durability%20fro%20pine%20heartwood%20phenolics.pdf.
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Wood is a naturally occurring, complex, structured, polymeric material comprised of a structural matrix in which are embedded a vast variety of extractible compounds. The organic carbon-rich matrix is susceptible to biodeterioration by a wide range of bacterial, fungal, insect and other organisms, despite protective effects of the extractives. Wood preservatives developed over the past 50 years have provided efficient ways of preventing biodeterioration, but many of them are under threat from
an increasingly chemophobic populace. Naturally bioactive wood extractives offer promise of control of many wood destroying organisms, and may be more acceptable
than these more powerful synthetic biocides. Phenolic compounds, relatively abundant extractives from the heartwood of Pinus spp., plantation-grown worldwide,
were evaluated for bioactivity.
Heartwood from Pinus spp. containing elevated phenolic concentrations was more resistant to subterranean termites than that from species characterized by low phenolics. While the stilbene phenolics were poorly related to resistance, the flavonoid phenolics appeared to be more closely associated with resistance. However, unspecified additional heartwood compounds contributed strongly to termite resistance. Both Pinus el/iottii and Pinus caribaea, previously classed with Pinus radiata as susceptible to termite attack, were naturally resistant to two significant Australian termite species. Acceptance of this resistance has enabled previous limitations on unpenetrated heartwood in these spp. to be removed from Australian requirements for preservative treatment against termites, with consequent economic benefit to the preservative treatment industry and consumers.
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Rein, Christian. "Enantioselektive Totalsynthese von (2R,4%27R,8%27R)-alpha-Tocopherol -Neues zur stereoselektiven Synthese der C12-C23-Substruktur von ( - )-Borrelidin /." München : Dr. Hut Verlag, 2008. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017094254&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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