Статті в журналах з теми "2015 h-825"

Abstract Background We conducted a phase II study to investigate the feasibility and safety of preoperative radiochemo-therapy experimental fractionation, using intensity-modulated radiation therapy with simultaneous integrated boost (IMRT SIB) to shorten the overall treatment time without dose escalation in intermediate/locally advanced rectal cancer with the aim to improving treatment outcome. Patients and methods A total of 51 patients with operable stage II–III rectal carcinoma were included between January 2014 and January 2015. Fifty patients completed preoperative IMRT treatment with an elective dose of 41.8 Gy and simultaneously delivered 46.2 Gy to T2/T3 and 48.4 Gy to T4 tumour in 22 fractions, with concomitant capecitabine (825 mg/m2/12 h, including at weekends). Median follow-up was 70 months (range 11–80 m). Results Forty-seven patients completed treatment per protocol. Acute toxicity occurred in 2 (4%) patients. R0 resection was achieved in all but 1 and pathologic complete response (pCR) in 12 (25.5%) patients who had 5-year overall survival (OS), disease-free survival (DFS) and local control (LC) of 91.7%, 100% and 100%, respectively. The intention-to-treat analysis showed that the type of surgery significantly moderated OS and DFS, while total downstaging and pN were predictive for DFS only. For treatment per protocol 5-year OS, DFS and LC were 80.9% (95% confidence interval [CI] 69.7–92.1), 77.1% (95% CI 65.1–89.1) and 95.2% (95% CI 88.7–100), respectively. The proportion of patients with severe late (CTCAE G ≥ 3) gastrointestinal, urinary and sexual toxicity was 15%, 2% and 8% respectively, with one reported secondary carcinoma. Conclusions Preoperative IMRT-SIB without dose escalation was well tolerated, with a low acute toxicity profile, we achieved a high rate of pCR and showed encouraging 5-year OS, DFS and LC.

We explored the sustainable business practices of selected Philippine corporations that promote the quest for peace. We used three key indicators of sustainable business practices, namely, fostering economic development, espousing corporate citizenship, and respecting the rule of law, as our variables to measure our sustainable business practices construct. On the other hand, we adopted sustainable development and sound business environmental our variables to measure the quest for peace construct. We assumed that sustainable business practices and quest for peace are interlinked and mutually reinforcing. We anchored our study on the Theories of Positive Peace, Sustainable Development, and Humanistic Management. We used the qualitative exploratory research design and the holistic multiple case study research strategy. We used the qualitative exploratory research design and the holistic multiple case study research strategy. We selected through the non-probability purposive sampling technique, the 20 Publicly - Listed Companies in the Philippines. We then, utilized the monomethod as the data collection technique for selecting the Sustainability Reports published in 2018 and uploaded in the websites of the respective corporations. With this deductive approach, we specifically adopted the pattern matching analytical procedure in the process of our content analysis of information from the Sustainability Reports. Results on fostering economic development revealed numerous jobs created, training and development, as well as trade and business development programs and activities executed. Analysis on espousing corporate citizenship disclosed many programs and activities related to encourage the use of voice from the firm, community engagement, and governance implemented. Findings on respecting the rule of law showed also various programs and activities that cover compliance with Philippine laws, international laws, and environmental standards. Findings also indicated that the nexus of sustainable business practices and the quest for peace aims to build companies of enduring greatness by doing good and working toward a sustainable future. In conducting responsible business, they were able to help in attaining positive peace in our coun try, which, in return, is essential for sustainable development, as manifested by their significant contribution in achieving sustainable development/growth, working closely with regulators to achieve shared goals; and protecting the environment and preserving natural resources. We recommend that there should be a coordinated effort of all the stakeholders to ensure that there is an integrated and holistic approach in the sustainability of the business sector to promote positive peace.We also propose to undertake further research on employing quantitative approach by using business, financial, and socio-economic indicators to address the limitations of this study. ReferencesBoulding, E. (2000). Cultures of peace: The hidden side of history. Syracuse University Press. Brauch, H. G., Oswald Spring, U., Grin, J., Scheffran, J. (Ed.). (2016). Handbook on sustainability transition and sustainable peace. Springer.Cortright, D. (2009). Peace: A history of movements and ideas. Cambridge University Press.Creswell, J. (2014). Research design: Qualitative, quantitative, and mixed methods approaches (4th ed.). Sage Publications.Edralin, D. & Pastrana, R. (2019). Sustainability initiatives and practices of selected top universities in Asia, Europe, and USA. 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In 2013 the Editor of Journal of Vibration and Control and SAGE became aware of a peer review ring involving assumed and fabricated identities that appeared to centre around Peter Chen at National Pingtung University of Education, Taiwan (NPUE). SAGE and the Editor then began a complex investigation into the case during the rest of 2013 and 2014. Following an unsatisfactory response from Peter Chen, NPUE was notified. NPUE were serious in addressing the Journal and SAGE’s concerns. NPUE confirmed that the institution was investigating Peter Chen. SAGE subsequently uncovered a citation ring involving the above mentioned author and others. We regret that individual authors have compromised the academic record by perverting the peer review process and apologise to readers. On uncovering problems with peer review and citation SAGE immediately put steps in place to avoid similar vulnerability of the Journal to exploitation in the future. More information may be found at www.sagepub.co.uk/JVC_Statement_2014 . The Journal and SAGE understand from NPUE that Peter Chen has resigned his post at NPUE. The following articles are retracted because after thorough investigation evidence points towards them having at least one author or being reviewed by at least one reviewer who has been implicated in the peer review ring and/or citation ring. All authors have had an opportunity to respond to the allegations and proposed actions. OnlineFirst articles (these articles will not be published in an issue) Chen CY, Chen T-H, Chen Y-H, Yu S-E and Chung P-Y (2013) Information technology system modeling an integrated C-TAM-TPB model to the validation of ocean tidal analyses Journal of Vibration and Control Epub ahead of print 7 May 2013. doi: 10.1177/1077546312472924 Chang R-F, Chen CY, Su F-P and Lin H-C (2013) A two-step approach for broadband digital signal processing technique Journal of Vibration and Control Epub ahead of print 26 April 2013. doi: 10.1177/1077546312472925 Chen TH, Chang CJ, Yu SE, Chung PY and Liu C-K (2013) Nonlinear information analysis and system management technique: the influence of design experience and control complexity Journal of Vibration and Control Epub ahead of print 12 April 2013. doi: 10.1177/1077546312473321 Chen CY, Shih BY, Chen YH, Yu SE and Liu YC (2013) The exploration of a 3T flow model using vibrating NXT: II. Model validation Journal of Vibration and Control Epub ahead of print 10 April 2013. doi: 10.1177/1077546312470481 Chen CY, Shih BY, Chen YH, Yu SE and Liu YC (2013) The exploration of 3T flow model using vibrating NXT: I. model formulation Journal of Vibration and Control Epub ahead of print 6 February 2013. doi: 10.1177/1077546312467360 Lin M-L and Chen C-W (2013) Stability analysis of fuzzy-based NN modeling for ecosystems using fuzzy Lyapunov methods Journal of Vibration and Control Epub ahead of print 6 February 2013. doi: 10.1177/1077546312466687 Chen CY, Chen TH, Chen YH and Chiu J (2012) A multi-stage method for deterministic-statistical analysis: a mathematical case and measurement studies Journal of Vibration and Control Epub ahead of print 20 December 2012. doi: 10.1177/1077546312466579 Shih BY, Lin MC and Chen CY (2012) Autonomous navigation system for radiofrequency identification mobile robot e-book reader Journal of Vibration and Control Epub ahead of print 13 December 2012. doi: 10.1177/1077546312466578 Chang RF, Chen CY, Su FP, Lin HC and Lu C-K (2012) Multiphase SUMO robot based on an agile modeling-driven process for a small mobile robot Journal of Vibration and Control Epub ahead of print 13 December 2012. doi: 10.1177/1077546312464993 Shih B-Y, Lin Y-K, Cheng M-H, Chen C-Y and Chiu C-P (2012) The development of an application program interactive game-based information system Journal of Vibration and Control Epub ahead of print 12 December 2012. doi: 10.1177/1077546312464682 Chen C-Y, Chang C-J and Lin C-H (2012) On dynamic access control in web 2.0 and cloud interactive information hub: technologies Journal of Vibration and Control Epub ahead of print 12 December 2012. doi: 10.1177/1077546312464992 Shin BY, Chen CY and Hsu KH (2012) Robot cross platform system using innovative interactive theory and selection algorithms for Android application Journal of Vibration and Control Epub ahead of print 13 November 2012. doi: 10.1177/1077546312463757 Articles published in an issue Chen C-W (2014) Applications of neural-network-based fuzzy logic control to a nonlinear time-delay chaotic system Journal of Vibration and Control 20 (4): 589-605. Epub ahead of print 5 November 2012. doi: 10.1177/1077546312461370 Chen C-W (2014) A review of intelligent algorithm approaches and neural-fuzzy stability criteria for time-delay tension leg platform systems Journal of Vibration and Control 20 (4): 561-575. Epub ahead of print 5 November 2012. doi: 10.1177/1077546312463759 Chen C-Y, Chang C-J and Lin C-H (2014) On dynamic access control in web 2.0 and cloud interactive information hub: trends and theories Journal of Vibration and Control 20 (4): 548-560. Epub ahead of print 5 November 2012. doi: 10.1177/1077546312463762 Lin M-L and Chen C-W (2014) Stability conditions for ecosystem modeling using the fuzzy Lyapunov method Journal of Vibration and Control 20 (2): 290-302. Epub ahead of print 23 October 2012. doi: 10.1177/1077546312451301 Chen C-H, Kuo C-M, Hsieh S-H and Chen C-Y (2014) Highly efficient very-large-scale integration (VLSI) implementation of probabilistic neural network image interpolator Journal of Vibration and Control 20 (2): 218-224. Epub ahead of print 22 October 2012. doi: 10.1177/1077546312458822 Chen C-Y (2014) Wave vibration and simulation in dissipative media described by irregular boundary surfaces: a mathematical formulation Journal of Vibration and Control 20 (2): 191-203. Epub ahead of print 22 October 2012. doi: 10.1177/1077546312464258 Chen C-H, Yao T-K, Dai J-H and Chen C-Y (2014) A pipelined multiprocessor system- on-a-chip (SoC) design methodology for streaming signal processing Journal of Vibration and Control 20 (2): 163-178. Epub ahead of print 16 October 2012. doi: 10.1177/1077546312458821 Lin M-L and Chen C-W (2014) Fuzzy neural modeling for n-degree ecosystems using the linear matrix inequality approach Journal of Vibration and Control 20 (1): 82-93. Epub ahead of print 8 October 2012. doi: 10.1177/1077546312458533 Chen C-H, Wu W-X and Chen C-Y (2013) Ant-inspired collective problem-solving systems Journal of Vibration and Control 19 (16): 2481-2490. Epub ahead of print 18 September 2012. doi: 10.1177/1077546312456231 Chen C-H, Yao T-K, Kuo C-M and Chen C-Y (2013) Evolutionary design of constructive multilayer feedforward neural network Journal of Vibration and Control 19 (16): 2413-2420. Epub ahead of print 12 September 2012. doi: 10.1177/1077546312456726 Chen C-W (2013) Applications of the fuzzy-neural Lyapunov criterion to multiple time-delay systems Journal of Vibration and Control 19 (13): 2054-2067. Epub ahead of print 16 August 2012. doi: 10.1177/1077546312451034 Chung P-Y, Chen Y-H, Walter L and Chen C-Y (2013) Influence and dynamics of a mobile robot control on mechanical components Journal of Vibration and Control 19 (13): 1923-1935. Epub ahead of print 20 July 2012. doi: 10.1177/1077546312452184 Chen C-W (2013) Neural network-based fuzzy logic parallel distributed compensation controller for structural system Journal of Vibration and Control 19 (11): 1709-1727. Epub ahead of print 22 June 2012. doi: 10.1177/1077546312442233 Chen C-W, Yeh K, Yang H-C, Liu KFR and Liu C-C (2013) A critical review of structural system control by the large-scaled neural network linear-deferential-inclusion-based criterion Journal of Vibration and Control 19 (11): 1658-1673. Epub ahead of print 18 June 2012. doi: 10.1177/1077546312443377 Chen C-H, Kuo C-M, Chen C-Y and Dai J-H (2013) The design and synthesis using hierarchical robotic discrete-event modeling Journal of Vibration and Control 19 (11): 1603-1613. Epub ahead of print 27 June 2012. doi: 10.1177/1077546312449645 Chang CJ, Chen CY and Chou I-T (2013) The design of information and communication technologies: telecom MOD strength machines Journal of Vibration and Control 19 (10): 1499-1513. Epub ahead of print 27 June 2012. doi: 10.1177/1077546312449644 Shih B-Y, Chen C-Y, Li K-H, Wu T-Y, Chen G-Y (2013) A novel NXT control method for implementing force sensing and recycling in a training robot Journal of Vibration and Control 19 (10): 1443-1459. Epub ahead of print 1 June 2012. doi: 10.1177/1077546312446361 Chen C-W, Chen P-C and Chiang W-L (2013) Modified intelligent genetic algorithm-based adaptive neural network control for uncertain structural systems Journal of Vibration and Control 19 (9): 1333-1347. Epub ahead of print 31 May 2012. doi: 10.1177/1077546312442232 Chen C-Y, Shih B-Y, Shih C-H and Wang L-H (2013) Enhancing robust and stability control of a humanoid biped robot: system identification approach. Journal of Vibration and Control 19 (8): 1199-1207. Epub ahead of print 26 April 2012. doi: 10.1177/1077546312442947 Chang C-J, Chen C-Y and Huang C-W (2013) Applications for medical recovery using wireless control of a bluetooth ball with a hybrid G-sensor and human-computer interface technology Journal of Vibration and Control 19 (8): 1139-1151. Epub ahead of print 24 April 2012. doi: 10.1177/1077546312442948 Hsu W-K, Chiou D-J, Chen C-W, Liu M-Y, Chiang W-L and Huang P-C (2013) Sensitivity of initial damage detection for steel structures using the Hilbert-Huang transform method Journal of Vibration and Control 19 (6): 857-878. Epub ahead of print 29 February 2012. doi: 10.1177/1077546311434794 Chen C-Y, Shih B-Y, Shih C-H and Wang L-H (2013) Human–machine interface for the motion control of humanoid biped robots using a graphical user interface Motion Editor Journal of Vibration and Control 19 (6): 814-820. Epub ahead of print 23 February 2012. doi: 10.1177/1077546312437804 Chen C-Y (2013) Internal wave transport, nonlinear manifestation, and mixing in a stratified shear layer - technical briefs Journal of Vibration and Control 19 (3): 429-438. Epub ahead of print 18 January 2012. doi: 10.1177/1077546311429337 Chen C-W (2013) Delay independent criterion for multiple time-delay systems and its application in building structure control systems Journal of Vibration and Control 19 (3): 395-414. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429341 Chen C-Y, Shih B-Y, Shih C-H and Wang L-H (2013) Design, modeling and stability control for an actuated dynamic walking planar bipedal robot Journal of Vibration and Control 19 (3): 376-384. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429476 Liu K-C, Liu Y-W, Chen C-Y and Huang W-C (2013) Nonlinear vibration of structural deterioration in reinforced concrete columns: experimental and theoretical investigation Journal of Vibration and Control 19 (3): 323-335. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429477 Chen C-Y, Shih B-Y and Ma J-m (2013) Development for low-cost and cross-platform robot control environment Journal of Vibration and Control 19 (2): 228-233. Epub ahead of print 11 January 2012. doi: 10.1177/1077546311430107 Shih B-Y, Chang H and Chen C-Y (2013) Path planning for autonomous robots – a comprehensive analysis by a greedy algorithm Journal of Vibration and Control 19 (1): 130-142. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429841 Liu T-Y, Chiang W-L, Chen C-W, Hsu W-K, Lin C-W, Chiou D-J and Huang P-C (2012) Structural system identification for vibration bridges using the Hilbert–Huang transform Journal of Vibration and Control 18 (13): 1939-1956. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311428347 Chen C-W (2012) Applications of the fuzzy Lyapunov linear matrix inequality criterion to a chaotic structural system Journal of Vibration and Control 18 (13): 1925-1938. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311428346 Chen C-W (2012) Applications of linear differential inclusion-based criterion to a nonlinear chaotic system: a critical review Journal of Vibration and Control 18 (12): 1886-1899. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311428345 Shih B-Y, Chen C-Y and Chou W (2012) An enhanced obstacle avoidance and path correction mechanism for an autonomous intelligent robot with multiple sensors Journal of Vibration and Control 18 (12): 1855-1864. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311426734 Chen C-W, Yeh K, Liu KFR and Lin M-L (2012) Applications of fuzzy control to nonlinear time-delay systems using the linear matrix inequality fuzzy Lyapunov method Journal of Vibration and Control 18 (10): 1561-1574. Epub ahead of print 18 October 2011. doi: 10.1177/1077546311410765 Chen C-Y (2012) A critical review of internal wave dynamics. Part 2 – Laboratory experiments and theoretical physics Journal of Vibration and Control 18 (7): 983-1008. Epub ahead of print 21 September 2011. doi: 10.1177/1077546310397561 Chen C-Y and Huang P-H (2012) Review of an autonomous humanoid robot and its mechanical control Journal of Vibration and Control 18 (7): 973-982. Epub ahead of print 21 September 2011. doi: 10.1177/1077546310395974 Shih B-Y, Chen C-Y, Chang H and Ma J-m (2012) Dynamics and control for robotic manipulators using a greedy algorithm approach Journal of Vibration and Control 18 (6): 859-866. Epub ahead of print 25 August 2011. doi: 10.1177/1077546311407649 Yeh K, Chen C-W, Lo DC and Liu KFR (2012) Neural-network fuzzy control for chaotic tuned mass damper systems with time delays Journal of Vibration and Control 18 (6): 785-795. Epub ahead of print 15 August 2011. doi: 10.1177/1077546311407538 Chen C-Y, Shih B-Y, Shih C-H and Chou W-C (2012) The development of autonomous low-cost biped mobile surveillance robot by intelligent bricks Journal of Vibration and Control 18 (5): 577-586. Epub ahead of print 21 April 2011. doi: 10.1177/1077546310371349 Chen C-Y (2012) A critical review of internal wave dynamics. Part 1 – Remote sensing and in-situ observations Journal of Vibration and Control 18 (3): 417-436. Epub ahead of print 13 July 2011. doi: 10.1177/1077546310395971 Tseng C-P, Chen C-W and Liu KFR (2012) Risk control allocation model for pressure vessels and piping project Journal of Vibration and Control 18 (3): 385-394. Epub ahead of print 13 July 2011. doi: 10.1177/1077546311403182 Lin M-L and Chen C-W (2011) Stability analysis of community and ecosystem hierarchies using the Lyapunov method Journal of Vibration and Control 17 (13): 1930-1937. Epub ahead of print 9 December 2010. doi: 10.1177/1077546310385737 Chen C-Y, Shih B-Y, Chou W-C, Li Y-J and Chen Y-H (2011) Obstacle avoidance design for a humanoid intelligent robot with ultrasonic sensors Journal of Vibration and Control 17 (12): 1798-1804. Epub ahead of print 26 November 2010. doi: 10.1177/1077546310381101 Chen C-W (2011) Fuzzy control of interconnected structural systems using the fuzzy Lyapunov method Journal of Vibration and Control 17 (11): 1693-1702. Epub ahead of print 23 November 2010. doi: 10.1177/1077546310379625 Shih B-Y, Chen C-Y and Chou W-C (2011) Obstacle avoidance using a path correction method for autonomous control of a biped intelligent robot Journal of Vibration and Control 17 (10): 1567-1573. Epub ahead of print 22 November 2010. doi: 10.1177/1077546310372004 Tang J-P, Chiou D-J, Chen C-W, Chiang W-L, Hsu W-K, Chen C-Y and Liu T-Y (2011) A case study of damage detection in benchmark buildings using a Hilbert-Huang Transform-based method Journal of Vibration and Control 17 (4): 623-636. Epub ahead of print 8 November 2010. doi: 10.1177/1077546309360053 Liu TY, Chiang WL, Chen CW, Hsu WK, Lu LC and Chu TJ (2011) Identification and monitoring of bridge health from ambient vibration data Journal of Vibration and Control 17 (4): 589-603. Epub ahead of print 12 November 2010. doi: 10.1177/1077546309360049 Lin JW, Huang CW, Shih CH and Chen CY (2011) Fuzzy Lyapunov Stability Analysis and NN Modeling for Tension Leg Platform Systems Journal of Vibration and Control 17 (1): 151-158. Epub ahead of print 25 August 2010. doi: 10.1177/1077546309350477 Lee WI, Chen CY, Kuo HM and Sui YC (2010) The Development of Half-circle Fuzzy Numbers and Application in Fuzzy Control Journal of Vibration and Control 16 (13): 1977-1987. Epub ahead of print 22 April 2010. doi: 10.1177/1077546309349849

In 2013 the Editor of Journal of Vibration and Control and SAGE became aware of a peer review ring involving assumed and fabricated identities that appeared to centre around Peter Chen at National Pingtung University of Education, Taiwan (NPUE). SAGE and the Editor then began a complex investigation into the case during the rest of 2013 and 2014. Following an unsatisfactory response from Peter Chen, NPUE was notified. NPUE were serious in addressing the Journal and SAGE’s concerns. NPUE confirmed that the institution was investigating Peter Chen. SAGE subsequently uncovered a citation ring involving the above mentioned author and others. We regret that individual authors have compromised the academic record by perverting the peer review process and apologise to readers. On uncovering problems with peer review and citation SAGE immediately put steps in place to avoid similar vulnerability of the Journal to exploitation in the future. More information may be found at www.sagepub.co.uk/JVC_Statement_2014 . The Journal and SAGE understand from NPUE that Peter Chen has resigned his post at NPUE. The following articles are retracted because after thorough investigation evidence points towards them having at least one author or being reviewed by at least one reviewer who has been implicated in the peer review ring and/or citation ring. All authors have had an opportunity to respond to the allegations and proposed actions. OnlineFirst articles (these articles will not be published in an issue) Chen CY, Chen T-H, Chen Y-H, Yu S-E and Chung P-Y (2013) Information technology system modeling an integrated C-TAM-TPB model to the validation of ocean tidal analyses Journal of Vibration and Control Epub ahead of print 7 May 2013. doi: 10.1177/1077546312472924 Chang R-F, Chen CY, Su F-P and Lin H-C (2013) A two-step approach for broadband digital signal processing technique Journal of Vibration and Control Epub ahead of print 26 April 2013. doi: 10.1177/1077546312472925 Chen TH, Chang CJ, Yu SE, Chung PY and Liu C-K (2013) Nonlinear information analysis and system management technique: the influence of design experience and control complexity Journal of Vibration and Control Epub ahead of print 12 April 2013. doi: 10.1177/1077546312473321 Chen CY, Shih BY, Chen YH, Yu SE and Liu YC (2013) The exploration of a 3T flow model using vibrating NXT: II. Model validation Journal of Vibration and Control Epub ahead of print 10 April 2013. doi: 10.1177/1077546312470481 Chen CY, Shih BY, Chen YH, Yu SE and Liu YC (2013) The exploration of 3T flow model using vibrating NXT: I. model formulation Journal of Vibration and Control Epub ahead of print 6 February 2013. doi: 10.1177/1077546312467360 Lin M-L and Chen C-W (2013) Stability analysis of fuzzy-based NN modeling for ecosystems using fuzzy Lyapunov methods Journal of Vibration and Control Epub ahead of print 6 February 2013. doi: 10.1177/1077546312466687 Chen CY, Chen TH, Chen YH and Chiu J (2012) A multi-stage method for deterministic-statistical analysis: a mathematical case and measurement studies Journal of Vibration and Control Epub ahead of print 20 December 2012. doi: 10.1177/1077546312466579 Shih BY, Lin MC and Chen CY (2012) Autonomous navigation system for radiofrequency identification mobile robot e-book reader Journal of Vibration and Control Epub ahead of print 13 December 2012. doi: 10.1177/1077546312466578 Chang RF, Chen CY, Su FP, Lin HC and Lu C-K (2012) Multiphase SUMO robot based on an agile modeling-driven process for a small mobile robot Journal of Vibration and Control Epub ahead of print 13 December 2012. doi: 10.1177/1077546312464993 Shih B-Y, Lin Y-K, Cheng M-H, Chen C-Y and Chiu C-P (2012) The development of an application program interactive game-based information system Journal of Vibration and Control Epub ahead of print 12 December 2012. doi: 10.1177/1077546312464682 Chen C-Y, Chang C-J and Lin C-H (2012) On dynamic access control in web 2.0 and cloud interactive information hub: technologies Journal of Vibration and Control Epub ahead of print 12 December 2012. doi: 10.1177/1077546312464992 Shin BY, Chen CY and Hsu KH (2012) Robot cross platform system using innovative interactive theory and selection algorithms for Android application Journal of Vibration and Control Epub ahead of print 13 November 2012. doi: 10.1177/1077546312463757 Articles published in an issue Chen C-W (2014) Applications of neural-network-based fuzzy logic control to a nonlinear time-delay chaotic system Journal of Vibration and Control 20 (4): 589-605. Epub ahead of print 5 November 2012. doi: 10.1177/1077546312461370 Chen C-W (2014) A review of intelligent algorithm approaches and neural-fuzzy stability criteria for time-delay tension leg platform systems Journal of Vibration and Control 20 (4): 561-575. Epub ahead of print 5 November 2012. doi: 10.1177/1077546312463759 Chen C-Y, Chang C-J and Lin C-H (2014) On dynamic access control in web 2.0 and cloud interactive information hub: trends and theories Journal of Vibration and Control 20 (4): 548-560. Epub ahead of print 5 November 2012. doi: 10.1177/1077546312463762 Lin M-L and Chen C-W (2014) Stability conditions for ecosystem modeling using the fuzzy Lyapunov method Journal of Vibration and Control 20 (2): 290-302. Epub ahead of print 23 October 2012. doi: 10.1177/1077546312451301 Chen C-H, Kuo C-M, Hsieh S-H and Chen C-Y (2014) Highly efficient very-large-scale integration (VLSI) implementation of probabilistic neural network image interpolator Journal of Vibration and Control 20 (2): 218-224. Epub ahead of print 22 October 2012. doi: 10.1177/1077546312458822 Chen C-Y (2014) Wave vibration and simulation in dissipative media described by irregular boundary surfaces: a mathematical formulation Journal of Vibration and Control 20 (2): 191-203. Epub ahead of print 22 October 2012. doi: 10.1177/1077546312464258 Chen C-H, Yao T-K, Dai J-H and Chen C-Y (2014) A pipelined multiprocessor system- on-a-chip (SoC) design methodology for streaming signal processing Journal of Vibration and Control 20 (2): 163-178. Epub ahead of print 16 October 2012. doi: 10.1177/1077546312458821 Lin M-L and Chen C-W (2014) Fuzzy neural modeling for n-degree ecosystems using the linear matrix inequality approach Journal of Vibration and Control 20 (1): 82-93. Epub ahead of print 8 October 2012. doi: 10.1177/1077546312458533 Chen C-H, Wu W-X and Chen C-Y (2013) Ant-inspired collective problem-solving systems Journal of Vibration and Control 19 (16): 2481-2490. Epub ahead of print 18 September 2012. doi: 10.1177/1077546312456231 Chen C-H, Yao T-K, Kuo C-M and Chen C-Y (2013) Evolutionary design of constructive multilayer feedforward neural network Journal of Vibration and Control 19 (16): 2413-2420. Epub ahead of print 12 September 2012. doi: 10.1177/1077546312456726 Chen C-W (2013) Applications of the fuzzy-neural Lyapunov criterion to multiple time-delay systems Journal of Vibration and Control 19 (13): 2054-2067. Epub ahead of print 16 August 2012. doi: 10.1177/1077546312451034 Chung P-Y, Chen Y-H, Walter L and Chen C-Y (2013) Influence and dynamics of a mobile robot control on mechanical components Journal of Vibration and Control 19 (13): 1923-1935. Epub ahead of print 20 July 2012. doi: 10.1177/1077546312452184 Chen C-W (2013) Neural network-based fuzzy logic parallel distributed compensation controller for structural system Journal of Vibration and Control 19 (11): 1709-1727. Epub ahead of print 22 June 2012. doi: 10.1177/1077546312442233 Chen C-W, Yeh K, Yang H-C, Liu KFR and Liu C-C (2013) A critical review of structural system control by the large-scaled neural network linear-deferential-inclusion-based criterion Journal of Vibration and Control 19 (11): 1658-1673. Epub ahead of print 18 June 2012. doi: 10.1177/1077546312443377 Chen C-H, Kuo C-M, Chen C-Y and Dai J-H (2013) The design and synthesis using hierarchical robotic discrete-event modeling Journal of Vibration and Control 19 (11): 1603-1613. Epub ahead of print 27 June 2012. doi: 10.1177/1077546312449645 Chang CJ, Chen CY and Chou I-T (2013) The design of information and communication technologies: telecom MOD strength machines Journal of Vibration and Control 19 (10): 1499-1513. Epub ahead of print 27 June 2012. doi: 10.1177/1077546312449644 Shih B-Y, Chen C-Y, Li K-H, Wu T-Y, Chen G-Y (2013) A novel NXT control method for implementing force sensing and recycling in a training robot Journal of Vibration and Control 19 (10): 1443-1459. Epub ahead of print 1 June 2012. doi: 10.1177/1077546312446361 Chen C-W, Chen P-C and Chiang W-L (2013) Modified intelligent genetic algorithm-based adaptive neural network control for uncertain structural systems Journal of Vibration and Control 19 (9): 1333-1347. Epub ahead of print 31 May 2012. doi: 10.1177/1077546312442232 Chen C-Y, Shih B-Y, Shih C-H and Wang L-H (2013) Enhancing robust and stability control of a humanoid biped robot: system identification approach. Journal of Vibration and Control 19 (8): 1199-1207. Epub ahead of print 26 April 2012. doi: 10.1177/1077546312442947 Chang C-J, Chen C-Y and Huang C-W (2013) Applications for medical recovery using wireless control of a bluetooth ball with a hybrid G-sensor and human-computer interface technology Journal of Vibration and Control 19 (8): 1139-1151. Epub ahead of print 24 April 2012. doi: 10.1177/1077546312442948 Hsu W-K, Chiou D-J, Chen C-W, Liu M-Y, Chiang W-L and Huang P-C (2013) Sensitivity of initial damage detection for steel structures using the Hilbert-Huang transform method Journal of Vibration and Control 19 (6): 857-878. Epub ahead of print 29 February 2012. doi: 10.1177/1077546311434794 Chen C-Y, Shih B-Y, Shih C-H and Wang L-H (2013) Human–machine interface for the motion control of humanoid biped robots using a graphical user interface Motion Editor Journal of Vibration and Control 19 (6): 814-820. Epub ahead of print 23 February 2012. doi: 10.1177/1077546312437804 Chen C-Y (2013) Internal wave transport, nonlinear manifestation, and mixing in a stratified shear layer - technical briefs Journal of Vibration and Control 19 (3): 429-438. Epub ahead of print 18 January 2012. doi: 10.1177/1077546311429337 Chen C-W (2013) Delay independent criterion for multiple time-delay systems and its application in building structure control systems Journal of Vibration and Control 19 (3): 395-414. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429341 Chen C-Y, Shih B-Y, Shih C-H and Wang L-H (2013) Design, modeling and stability control for an actuated dynamic walking planar bipedal robot Journal of Vibration and Control 19 (3): 376-384. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429476 Liu K-C, Liu Y-W, Chen C-Y and Huang W-C (2013) Nonlinear vibration of structural deterioration in reinforced concrete columns: experimental and theoretical investigation Journal of Vibration and Control 19 (3): 323-335. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429477 Chen C-Y, Shih B-Y and Ma J-m (2013) Development for low-cost and cross-platform robot control environment Journal of Vibration and Control 19 (2): 228-233. Epub ahead of print 11 January 2012. doi: 10.1177/1077546311430107 Shih B-Y, Chang H and Chen C-Y (2013) Path planning for autonomous robots – a comprehensive analysis by a greedy algorithm Journal of Vibration and Control 19 (1): 130-142. Epub ahead of print 17 January 2012. doi: 10.1177/1077546311429841 Liu T-Y, Chiang W-L, Chen C-W, Hsu W-K, Lin C-W, Chiou D-J and Huang P-C (2012) Structural system identification for vibration bridges using the Hilbert–Huang transform Journal of Vibration and Control 18 (13): 1939-1956. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311428347 Chen C-W (2012) Applications of the fuzzy Lyapunov linear matrix inequality criterion to a chaotic structural system Journal of Vibration and Control 18 (13): 1925-1938. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311428346 Chen C-W (2012) Applications of linear differential inclusion-based criterion to a nonlinear chaotic system: a critical review Journal of Vibration and Control 18 (12): 1886-1899. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311428345 Shih B-Y, Chen C-Y and Chou W (2012) An enhanced obstacle avoidance and path correction mechanism for an autonomous intelligent robot with multiple sensors Journal of Vibration and Control 18 (12): 1855-1864. Epub ahead of print 14 December 2011. doi: 10.1177/1077546311426734 Chen C-W, Yeh K, Liu KFR and Lin M-L (2012) Applications of fuzzy control to nonlinear time-delay systems using the linear matrix inequality fuzzy Lyapunov method Journal of Vibration and Control 18 (10): 1561-1574. Epub ahead of print 18 October 2011. doi: 10.1177/1077546311410765 Chen C-Y (2012) A critical review of internal wave dynamics. Part 2 – Laboratory experiments and theoretical physics Journal of Vibration and Control 18 (7): 983-1008. Epub ahead of print 21 September 2011. doi: 10.1177/1077546310397561 Chen C-Y and Huang P-H (2012) Review of an autonomous humanoid robot and its mechanical control Journal of Vibration and Control 18 (7): 973-982. Epub ahead of print 21 September 2011. doi: 10.1177/1077546310395974 Shih B-Y, Chen C-Y, Chang H and Ma J-m (2012) Dynamics and control for robotic manipulators using a greedy algorithm approach Journal of Vibration and Control 18 (6): 859-866. Epub ahead of print 25 August 2011. doi: 10.1177/1077546311407649 Yeh K, Chen C-W, Lo DC and Liu KFR (2012) Neural-network fuzzy control for chaotic tuned mass damper systems with time delays Journal of Vibration and Control 18 (6): 785-795. Epub ahead of print 15 August 2011. doi: 10.1177/1077546311407538 Chen C-Y, Shih B-Y, Shih C-H and Chou W-C (2012) The development of autonomous low-cost biped mobile surveillance robot by intelligent bricks Journal of Vibration and Control 18 (5): 577-586. Epub ahead of print 21 April 2011. doi: 10.1177/1077546310371349 Chen C-Y (2012) A critical review of internal wave dynamics. Part 1 – Remote sensing and in-situ observations Journal of Vibration and Control 18 (3): 417-436. Epub ahead of print 13 July 2011. doi: 10.1177/1077546310395971 Tseng C-P, Chen C-W and Liu KFR (2012) Risk control allocation model for pressure vessels and piping project Journal of Vibration and Control 18 (3): 385-394. Epub ahead of print 13 July 2011. doi: 10.1177/1077546311403182 Lin M-L and Chen C-W (2011) Stability analysis of community and ecosystem hierarchies using the Lyapunov method Journal of Vibration and Control 17 (13): 1930-1937. Epub ahead of print 9 December 2010. doi: 10.1177/1077546310385737 Chen C-Y, Shih B-Y, Chou W-C, Li Y-J and Chen Y-H (2011) Obstacle avoidance design for a humanoid intelligent robot with ultrasonic sensors Journal of Vibration and Control 17 (12): 1798-1804. Epub ahead of print 26 November 2010. doi: 10.1177/1077546310381101 Chen C-W (2011) Fuzzy control of interconnected structural systems using the fuzzy Lyapunov method Journal of Vibration and Control 17 (11): 1693-1702. Epub ahead of print 23 November 2010. doi: 10.1177/1077546310379625 Shih B-Y, Chen C-Y and Chou W-C (2011) Obstacle avoidance using a path correction method for autonomous control of a biped intelligent robot Journal of Vibration and Control 17 (10): 1567-1573. Epub ahead of print 22 November 2010. doi: 10.1177/1077546310372004 Tang J-P, Chiou D-J, Chen C-W, Chiang W-L, Hsu W-K, Chen C-Y and Liu T-Y (2011) A case study of damage detection in benchmark buildings using a Hilbert-Huang Transform-based method Journal of Vibration and Control 17 (4): 623-636. Epub ahead of print 8 November 2010. doi: 10.1177/1077546309360053 Liu TY, Chiang WL, Chen CW, Hsu WK, Lu LC and Chu TJ (2011) Identification and monitoring of bridge health from ambient vibration data Journal of Vibration and Control 17 (4): 589-603. Epub ahead of print 12 November 2010. doi: 10.1177/1077546309360049 Lin JW, Huang CW, Shih CH and Chen CY (2011) Fuzzy Lyapunov Stability Analysis and NN Modeling for Tension Leg Platform Systems Journal of Vibration and Control 17 (1): 151-158. Epub ahead of print 25 August 2010. doi: 10.1177/1077546309350477 Lee WI, Chen CY, Kuo HM and Sui YC (2010) The Development of Half-circle Fuzzy Numbers and Application in Fuzzy Control Journal of Vibration and Control 16 (13): 1977-1987. Epub ahead of print 22 April 2010. doi: 10.1177/1077546309349849

Fluctuations in supply and demand result in wasted energy during off-peak electric grid hours, with Reversible Solid Oxide Cells (RSOCs) potentially providing an efficient means by which such energy can be stored to create a highly sustainable grid.1 A RSOC can catalyze reactions such as the CO2 Reduction Reaction (CO2RR) by operating in the Solid Oxide Electrolysis Cell (SOEC) mode when energy supply is high, or in the Solid Oxide Fuel Cell (SOFC) mode when demand is high while oxidizing CO.1 The estimated yearly energy storage requirement is about 2-3 months per year, with RSOCs capable of achieving this goal.1 Single phase perovskite materials with the composition La0.3M0.7Fe0.7Cr0.3O3-δ (M = Sr, Ca) (LMFCr) have emerged as promising electrocatalysts for both fuel and oxygen electrodes in symmetrical RSOCs due to their phase stability in air and fuels (pO2 ~ 0.21 – 10-21 atm) and their compatibility with doped ceria-buffered yttria- and scandia-stabilized zirconia (YSZ/SSZ) electrolytes.2,3 The Ca analogue of LMFCr (LCFCr) has generally shown better performance and compatibility with other cell components,3 with significant efforts directed towards further enhancing its CO2RR activity by employing various approaches, including nanoscale modifications.4 One such technique is nanoparticle (NP) exsolution, which can greatly increase the catalytic surface area.5 This method employs B-site doping with Ni or Co followed by exposure to reducing conditions to decorate the catalyst surface with B-site metal alloy NPs.4 These are strongly anchored to the bulk material, highly resistant to coking, and stable under the harsh conditions of RSOCs.4 In our initial work, the exsolution characteristics of Fe-Ni NPs from 5% Ni-doped LCFCr (LCFCrN) were studied in H2:N2 and CO2:CO atmospheres using ex situ XRD, SEM, and STEM-EDS.4 Exsolution kinetics were rapid in H2:N2 (pO2 ~ 10-23 atm) at 800 °C with NPs assuming an average size of 45 nm and an Fe-rich Fe0.64Ni0.36 composition within 1 h exposure to 5H2:95N2. On the other hand, 70CO:30CO2 atmospheres (pO2 ~ 10-20 atm) gave sluggish kinetics with the NPs achieving an average size of 40 nm and a Ni-rich FeNi3 composition even after more than 25 hours of treatment. This suggests stability to coarsening in highly reducing atmospheres.4 In more recent work, 5% Co-doped LCFCr (LCFCrCo) perovskites show visible Fe-Co NP formation at 800 °C upon exposure to 5H2:95N2 for at least 1 h or to 70CO:30CO2 for at least 5 h. Electrochemical characterization of Fe-Ni NP decorated LCFCrN (Fe-Ni@LCFCrN) was conducted on 2.5 cm diameter cells using ceria-buffered SSZ electrolyte. A LCFCrN ink was screen-printed onto a ~0.5 cm2 area on both sides of the cell followed by sintering at 1100 °C for 2 h. Au was painted onto each electrode, and the cell was sintered again at 825 °C for 1 h. Electrical connections were made via Au gauzes and wires. NP exsolution was induced by exposing the fuel electrode to 5H2:95N2 for 2 h at 800 °C. Various CO2:CO mixtures (100:0, 90:10, 70:30, 50:50) were supplied to the fuel electrode while air was supplied to the oxygen electrode with flow rates of 50 mL/min. Electrochemical performance was tested via cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronoamperometry. CVs showed that the NPs enhanced LCFCrN activity for CO2RR (~ 15%) and more notably for CO oxidation (~ 75%) at the same overpotential (~ 0.7 V), making the catalyst equally active for the two reactions. 15-minute potentiostatic tests indicated stable current densities of about –0.65, –0.634, and –0.618 A/cm2 in 100% CO2, 90CO2:10CO, and 70CO2:30CO respectively at a cell potential of 1.6 V. Medium-term (10 h) potentiostatic tests for CO2RR indicated excellent stability with a current density of –0.28 A/cm2 at a cell potential of 1.3 V in 70CO2:30CO (pO2 ~ 10-18 atm). The excellent electrochemical performance in both the SOFC and SOEC modes makes Fe-Ni@LCFCrN a very promising electrode material for RSOCs. Further work on LCFCrCo is underway, with comparisons being made between LCFCrN and LCFCrCo on CO2-CO electrocatalysis and NP characteristics. References Jensen, S. H.; Graves, C.; Mogensen, M.; Wendel, C.; Braun, R.; Hughes, G.; Gao, Z.; Barnett, S. A. Energy Environ. Sci. 8, 2471 (2015). Molero-Sánchez, B.; Addo, P.; Buyukaksoy, A.; Paulson, S.; Birss, V. I. Faraday Discuss. 182, 159 (2015). Molero-Sánchez, B.; Prado-Gonjal, J.; Avila-Brande, D.; Chen, M.; Moran, E.; Birss, V. I. J. Hydrog. Energy. 40, 1902 (2015). Ansari, H. M.; Bass, A. S.; Ahmad, N.; Birss, V. I. Mater. Chem. A (2022). Zhu, Y.; Dai, J.; Zhou, W.; Zhong, Y.; Wang, H.; Shao, Z. Mater. Chem. A. 6, 13582 (2018).

Sodium metal is a promising anode for batteries because of its high theoretical specific capacity (1165 mAh g-1) and great abundance and low cost. However, fundamental issues such as dendrite formation, “dead sodium” accumulation during cycling, fast SEI dissolution or continuous SEI growth bring challenges for stabilizing reversibility of sodium metal anode. Recent advances in electrolyte engineering and development of highly stable cathode materials have enables sodium metal batteries reaching high CE (>99 %) at room temperature1-5. Herein, we report a feasible pathway toward further stabilization of sodium metal anode using tetraglyme solvent (TEGDME) based electrolyte with various sodium salts (NaBF4, NaPF6, NaTFSI, NaFSI, NaClO4, NaOTf). It is demonstrated that a Na||Cu cell exhibited an average Coulombic efficiency of 99.9 % over 200, 850, and 1000 plating-stripping cycles when an electrolyte of 1M NaOTf in TEGDME, 1M NaPF6 in TEGDME, and 1M NaBF4 in TEGDME were used, respectively. Furthermore, 1M NaBF4 in TEGDME electrolyte also enabled excellent cycling stability of Na||Na3V2(PO4)2 batteries at high rate (1 C) for 1000 cycles with capacity retention of 90.8 %. References Seh, Z. W.; Sun, J.; Sun, Y.; Cui, Y. A Highly Reversible Room Temperature Sodium Metal Anode. ACS Cent. Sci. 2015, 1, 449−455. Cao, R.; Mishra, K.; Li, X.; Qian, J.; Engelhard, M. H.; Bowden, M. E.; Han, K. S.; Mueller, K. T.; Henderson, W. A.; Zhang, J.-G. Enabling Room Temperature Sodium Metal Batteries. Nano Energy 2016, 30, 825−830. Zheng, J.; Chen, S.; Zhao, W.; Song, J.; Engelhard, M.H.; Zhang, J.G. Extremely Stable Sodium Metal Batteries Enabled By Localized High-Concentration Electrolytes, ACS. Energy. Lett. 2018, 315−321. Goktas, M.; Bolli, C.; Buchkheim, J.; Berg, E. J; Novak, P.; Bonilla, F.; Rojo, T.; Komaba, S.; Kubota, K.; Adelhem, P.; Stable and Unstable Diglyme-Based Electrolytes for Batteries With Sodium or Graphite as Electrode., ACS Appl. Mater. Interfaces 2019, 11, 32844-32855. Le, P.M.L; Vo, D.T; Pan, H., Yan, J.; He, Y.; Cao, X.; Nguyen, H.V; Engelhard, M.H; Wang, C.; Xiao, J.; Zhang, J-G., Excellent Cycling Stability of Sodium Anode Enabled by a Stable Solid Electrolyte Interphase Formed in Ether-Based Electrolytes, Adv. Funct. Mater. 2020, 30, 2001151 Acknowledgement This work is supported by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of Vehicle Technologies of the US Department of Energy (DOE) through the Advanced Battery Materials Research (BMR) program under contract no. DE-AC05-76RLO1830.

Electrokinetic phenomena within complex structures are relevant in microfluidics. For example, ion concentration polarization is used for electrokinetic trapping for enhanced biosensing using molecular probes1. Concentration polarization near ion-selective membranes also plays an important role in separation systems for desalination2. Aside from microfluidics, electrochemical growth-dissolution phenomenon has been reported in lithium ion battery systems where lithium plating and subsequent growth of dendrites can exacerbate the loss of cyclable lithium through the formation of isolated Lithium (i-Li) islands3. Initially thought to be “dead”, these islands were shown to migrate from one electrode to the other through a deposition-dissolution mechanism3. We present a mathematical solution for the growth and migration of an electrochemically active metal particle in a background current. A broad range of phenomena such as viscous fingering4, diffusion-limited aggregation4 and electrochemical deposition5 follow Laplacian growth and have been traditionally described using conformal map-dynamics in two dimensions. Some non-Laplacian phenomena like electrochemical transport6,7 and advection-diffusion-limited aggregation6 fall into the conformally invariant category8 and can still be simplified using conformal-mapping techniques. Our solution applies conformal mapping to the non-Laplacian growth of the metal particle to evaluate the role of particle morphology in the evolution of the phase boundary. In addition to migration, dissolution-deposition was found to lead to formation of cusps on the phase boundary under certain conditions. The solution is applicable for a general class of problems with a reactive post or particle in an applied background flux. Analytical solutions such as the one presented here are expected to augment numerical simulations and lead to expressions that capture conditions for the onset of morphological instabilities. References S. Park, B. Sabbagh, R. Abu-Rjal, and G. Yossifon, Lab Chip, 22, 814–825 (2022) https://pubs.rsc.org/en/content/articlehtml/2022/lc/d1lc00864a. D. Deng et al., Desalination, 357, 77–83 (2015). F. Liu et al., Nature 2021 600:7890, 600, 659–663 (2021) https://www.nature.com/articles/s41586-021-04168-w. J. Mathiesen, I. Procaccia, H. L. Swinney, and M. Thrasher, Europhys Lett, 76, 257 (2006) https://iopscience.iop.org/article/10.1209/epl/i2006-10246-x. D. A. Kessler, J. Koplik, and H. Levine, http://dx.doi.org/10.1080/00018738800101379, 37, 255–339 (2006) https://www.tandfonline.com/doi/abs/10.1080/00018738800101379. M. Z. Bazant, J. Choi, and B. Davidovitch, Phys Rev Lett, 91, 045503 (2003) https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.91.045503. Z. Gu et al., Phys Rev Fluids, 7, 033701 (2022) https://journals.aps.org/prfluids/abstract/10.1103/PhysRevFluids.7.033701. M. Z. Bazant, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, 460, 1433–1452 (2004) https://royalsocietypublishing.org/doi/10.1098/rspa.2003.1218.

Based on the data of daily maximum temperature in 26 meteorological stations in the North Center Region, Vietnam over the period of 1980 to 2013, the authors conducted the research on the spatial distribution of the number of hot days. The initial result shows that in general, in the north of the study area, the large number of hot days occurred in the plain, and tended to decrease westward and eastward. In the south, this number tends to increase from the west to the east. Especially, the largest number occurred in two areas: The Ma and Ca River's valleys (Thanh Hoa and Nghe An provinces) and the coastal areas (Thua Thien Hue province), creating two heat centers in Tuong Duong district, Nghe An province and Nam Dong district, Thua Thien Hue province.ReferencesAdina-Eliza Croitoru, Adrian Piticar, Antoniu-Flavius Ciupertea, Cristina FlorinaRosca, 2016 Changes in heat wave indices in Romania over the period 1961-2015. Global and Plantary Change 146. Journal homepage: www. Elsevier.com/locate/gloplacha.Chu Thi Thu Huong et al., 2010. Variations and trends in hot event in Vietnam from 1961-2007, VNU Journal of Science and Technology, 26(3S).Climate Council, 2014a. Angry Summer 2013/2014. Accessed at http://www.climatecouncil.org.au/ angry-summer.Climate Council, 2014b. Angry Summer 2013/2014. Accessed at http://www.climatecouncil.org.au/ angry-summer.CSIRO and BoM, 2012. State of the Climate 2012.CSIRO and Bureau of Meteorology, Melbourne.Accessed at http://www.csiro.au/Outcomes/ Climate/Understanding/State-of-the-Climate-2012.aspx.D'Ippoliti D., Michelozzi P., Marino C., De'Donato F., Menne B., Katsouyanni K., Kirchmayer U., Analitis A., Medina-Ramon M., Paldy A., Atkinson R., Kovats S., Bisanti L., Schneider A., Lefranc A., Iñiguez C., Perucci C., 2010. The impact of heat waves on mortality in 9 European cities: results from the EuroHEAT project. Environ. Health 9, 37. http://dx.doi.org/10.1186/1476-069X-9-37.Gerald A. Meehl, 1992. Effect of tropical topography on global climate, Ann. Rev. Earth Planet. Sci., 20, 85-112.Hayhoe K., Cayan D., Field C.B., Frumhoff P.C., Maurer E.P., Miller N.L., Moser S.C., Schneider S.H., Cahill K.N., Cleland E.E., Dale L., Drapek R., Hanemann R.M., lkstein L.S., Lenihan J., Lunch C.K., Neilson R.P., Sheridan S.C., Verville J.H., 2004. Emissions pathways, climate change, and impacts on California. PNAS, 101(34), 12422-12427.Ho Thi Minh Ha, Phan Van Tan, 2009. Trends and variations of extreme temperature in Vietnam in the period from 1961 to 2007, VNU Journal of Science and Technology, 25(3S).IPCC, 2007: Climate Change 2007: Synthesis Report. Contribution of Working Groups I, II and III to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change [Core Writing Team, Pachauri R.K and Reisinger A. (eds.)]. IPCC, Geneva, Switzerland, 104p.IPCC, 2014. Climate Change 2014: Synthesis Report. Contribution of Working Groups I, II and III to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change [Core Writing Team, R.K. Pachauri and L.A. Meyer (eds.)]. IPCC, Geneva, Switzerland, 151p.Liu G., Zhang L., He B., Jin X., Zhang Q., Razafindrabe B., You H., 2015. Temporal changes in extreme high temperature, heat waves and relevant disasters in Nanjing metropolitan region, China. Nat. Hazards, 76, 1415–1430. http://dx.doi.org/10.1007/s11069-014-1556-y.Manton M.J et al., 2001. Trends in extreme daily temperature in Southeast Asia Rainfall ad and the South Pacific, J. Climatol. 21.Nairn J.R., Fawcett R.J.B., 2015. Int. J. Environ. Res. Public Health 12, 227–253. http://dx.doi.org/10.3390/ijerph120100227.Nguyen Duc Ngu, 2009. Climate Change Challenges to development, Journal of Economy and Environment, No. 1.Perkins S.E., Alexander L.V., 2013. On the measurement of heat waves. J. Clim. 26, 4500–4517. http://dx.doi.org/10.1175/JCLI-D-12-00383.1.Peterson T.C., Heim Jr. R.R., Hirsch R., Kaiser D.P., Brooks H., Diffenbaugh N.S., Dole R.M., Giovannettone J.P., Guirguis K., Karl T.R., Katz R.W., Kunkel K., Lettenmaier D., McCabe G.J., Paciorek C.J., Ryberg K.R., Schubert S., Silva V.B.S., Stewart B.C., Vecchia A.V., Villarini G., Vose R.S., Walsh J., Wehner M., Wolock D., Wolter K., Woodhouse C.A., Wuebbles D., 2013. Monitoring and understanding changes in heat waves, cold waves, floods, and droughts in the United States: state of knowledge. Bull. Amer. Meteor. Soc., 94, 821–834.Pham Thi Ly, Hoang Luu Thu Thuy, 2015. Variation of heat waves in the North Central Region over the period of 1980-2013, Journal of natural resources and environment, 9, 81-89.Phan Van Tan et al., 2010. Study impact of global climate change on extreme weather phenomena and factors in Vietnam, prediction and adaptation strategies. Project final report, KC 08.29/06-10, Hanoi University of Science.Spinoni J., Lakatos M., Szentimrey T., Bihari Z., Szalai S., Vogt J., Antofie T., 2015. Heat and cold waves trends in Carpathian Region from 1961 to 2010. Int. J. Climatol, 35, 4197–4209. http://dx.doi.org/10.1002/joc.4279.Toreti A., Desiato F., 2008.Temperature trends over Italy from 1961 to 2004, Theor. Appl. Climatol 91.Tran Cong Minh, 2007. Principle of meteorology and climate, Book, Public House of Hanoi National University.Tran Quang Duc, Trinh Lan Phuong, 2013. Changes of Hot day and Fohn Activities at Ha Tinh- Central Vietnam, VNU Journal of Science, Science and Technology, 29(2S).Trewin B., Smalley R., 2013.Changes in extreme temperature in Australia, 1910 to 2011. In: 19th AMOS National Conference, Melbourne, 11-13.Unal Y.S., Tan E., Mentes S.S., 2013. Summer heat waves over western Turkey between 1965 and 2006.Theor. Appl. Climatol, 112, 339–350. http://dx.doi.org/10.1007/s00704-012-0704-0.Will Steffen, 2015. Quantifying the impact of climate change on extreme heat in Australia. Published by the Climate Council of Australia Limited. ISBN: 978-0-9942453-1-1 (print) 978-0-9942453-0-4 (web).

Setiap kota tumbuh dan berkembang sesuai dengan potensi dan dinamika yang ada di dalamnya. Agar perkembangan kota tersebut dapat terarah dan teratur diperlukan suatu pedoman bagi kegiatan pembangunan dan pemanfaatan ruang. Pedoman bagi kegiatan pembangunan dan pemanfaatan ruang kota tersebut adalah Rencana Tata Ruang Wilayah Kota (RTRW) serta peraturan yang terkait dengan aktivitas pemanfaatan ruangnya.Dalam RTRW Kota Pontianak, masing-masing wilayah merupakan bagian wilayah kota yang menjadi fokus perencanaan. Perkembangan wilayah akan membawa pengaruh terhadap pemanfaatan ruang yang ada. Hal ini dapat dilihat dari beberapa fenomena yang terjadi, yaitu adanya penyimpangan terhadap pemanfaatan ruang yang sudah ditetapkan dalam rencana tata ruang. Kondisi ini dapat dilihat dengan mudah pada ruas-ruas jalan utama yang menjadi cerminan wajah Kota Pontianak. Pada ruas jalan utama masih banyak terdapat bangunan yang berdiri tidak sesuai dengan aturan rencana tata ruang dan tata bangunan yang ada. Akibat lebih jauh dari kondisi ini adalah penataan bangunan sebagai inti fisik kota terkesan kurang teratur dan berkembang tidak sesuai harapan.Tujuan penelitian ini adalah melakukan identifikasi terhadap pemanfaatan ruang bagi aktivitas mendirikan bangunan di sepanjang koridor Jalan Kom Yos Sudarso Pontianak yang merupakan salah satu jalan utama di Kota Pontianak untuk melihat kesesuaiannya dengan peraturan tata ruang dan bangunan yang berlaku khususnya peraturan yang berkaitan dengan perencanaan RMJ dan GSB pada kawasan tersebut.Penelitian ini menggunakan desain riset deskriftif dengan survei sebagai instrumen penelitian, yaitu dengan melakukan obsevasi dan pengamatan langsung dilapangan untuk memperoleh data primer berkaitan dengan jumlah dan karakteristik bangunan di sepanjang koridor Jalan Kom Yos Sudarso Pontianak. Analisis yang digunakan adalah analisis deskriftif untuk melihat frekuensi dan pola sebaran data yang dimati. Dari analisis tersebut maka dapat diketahui gambaran tentang frekuensi, kecenderungan serta pola sebaran aktivitas mendirikan bangunan di sepanjang koridor jalan Kom Yos Sudarso Pontianakterhadap penerapan peraturan tata ruang dan bangunan pada wilayah penelitian.Hasil identifikasi didapat 216 unit bangunan atau 17,2 % terkena perencanaan RMJ dan sebagian besar adalah bangunan dengan fungsi usaha. Sementara itu, bangunan yang tidak sesuai dengan penataan GSB pada wilayah penelitian ini sebesar 825 unit bangunan atau mencapai 65,6 % dari seluruh bangunan yang diamati. Fungsi bangunan yang paling banyak melanggar aturan penataan GSB adalah bangunan dengan fungsi usaha serta bangunan yang berfungsi sebagai hunian dan usaha yang mencapai 41,9 % dan 14,3 % dari total bangunan yang di amati.Kata-Kata Kunci: Pemanfaatan Ruang, Aktivitas Mendirikan Bangunan, Koridor JalanIDENTIFICATION ON THE ACTIVITIES OF BUILDING CONSTRUCTION WITH REGARD TO SPATIAL USE AT KOM YOS SUDARSO’S STREET CORRIDORS PONTIANAKEvery city grows and develops according to the potential and dynamics the city has in itself. For the development of the city to be orderly and well directed, a guideline is needed for development activities and spatial utilization. Such a guideline for the development and utilization of urban space is known as Urban Spatial Plans (RTRW) as well as regulations related to the activities of spatial utilization. In the RTRW of Pontianak City, each region is a part of the city that becomes the focus of planning. The development of a region will obviously affect the utilization of existing space. This can be seen from several phenomena that occur, namely deviation against space utilization that has been defined in the spatial plan. This condition can easily be seen on the sections of main roads that constitute as reflection of the face of Pontianak City. On the main road, sections there are still found many buildings that are not in accordance with the existing spatial plan and building layout. A further consequence of such a condition is that the arrangement of buildings as the physical core of the city seems to be less organized and develops not as it had been expected to be.The purpose of this study is to identify the use of space for the activity of building constructions along the corridor of Kom Yos Sudarso Pontianak street which is one of the main roads in Pontianak City and to see if they are in compliance with the existing spatial and building regulations, particularly the regulations relating to the RMJ plans (Street Owned Space) and GSB (Building Border Line) on the area in question. This research uses descriptive research design with a survey as its main research instrument by conducting observation and direct field observation to get the primary data related to the numbers and characteristics of the buildings along the corridor of Kom Yos Sudarso Street, Pontianak. The analysis used is descriptive analysis to see the frequency and pattern of data distribution being observed. From the analysis, it could be seen that the description of the frequency, tendency and patterns of building activity distribution along the corridor of Kom Yos Sudarso Street Pontianak with regard to the implementation of spatial and building regulations in the researched area.Identification results obtained 216 building units or 17.2% exposed to planning RMJ and as large is a building with business functions. Meanwhile, buildings that are inconsistent with the GSB structuring in this research area are 825 units of buildings or 65.6% of all buildings observed. Building functions that most violate GSB structuring rules are buildings with business functions as well as buildings that serve as occupancy and businesses that reach 41.9% and 14.3% of the total buildings observed.Keywords: Space Utilization, Building Activity, Road CorridorREFERENCESIrawati, H.,Haryanto, R. (2015). Perubahan Fungsi Lahan Koridor Jalan Selokan Mataram Kabupaten Sleman. Jurnal Teknik PWK Vol. 4 No. 2 (2015)Kementerian Hukum dan HAM RI. (2007). Undang - Undang Nomor 26 Tahun 2007 Tentang Penataan Ruang. Kementerian Hukum dan HAM RI. JakartaKementerian Hukum dan HAM RI. (2002). Undang – Undang Nomor 28 Tahun 2002 Tentang Bangunan GedungKementerian Pekerjaan Umum RI. (2007). Peraturan Menteri Pekerjaan Umum Nomor: 06/PRT/M/2007 Tanggal 16 Maret 2007 Tentang Pedoman Umum Rencana Tata Bangunan Dan Lingkungan. Kementerian Pekerjaan Umum RI. JakartaNurmandi, A. (1999), Manajemen Perkotaan. Lingkaran Bangsa. YogyakartaSekretariat Daerah Kota Pontianak. (2008). Peraturan Daerah Kota Pontianak No. 3 Tahun 2008 tentang Bangunan Gedung. Sekretariat Daerah Kota Pontianak. PontianakSekretariat Daerah Kota Pontianak. (2013). Peraturan Daerah Kota Pontianak No. 2 Tahun 2013 tentang RTRW Kota Pontianak. Sekretariat Daerah Kota Pontianak. PontianakWardhana, I, W., Haryanto, R. (2016). Kajian Pemanfaatan Ruang Kegiatan Komersial Koridor Jalan Taman Siswa Kota Semarang . Jurnal Pengembangan Kota Volume 4 No. 1 : 49–57 (2016)Yahya, M. (2015). Kajian Tata Bangunan dan Lingkungan pada Koridor Jalan Perintis Kemerdekaan Kota Makassar. Prosiding Temu Ilmiah IPLBI 2015. B.033-B.038

PurposeThis randomized, double-blind, placebo-controlled, parallel-group, phase II trial assessed the efficacy and safety of adagloxad simolenin (OBI-822; a Globo H epitope covalently linked to keyhole limpet hemocyanin (KLH)) with adjuvant OBI-821 in metastatic breast cancer (MBC).MethodsAt 40 sites in Taiwan, USA, Korea, India, and Hong Kong, patients with MBC of any molecular subtype and ≤2 prior progressive disease events with stable/responding disease after the last anticancer regimen were randomized (2:1) to adagloxad simolenin (AS/OBI-821) or placebo, subcutaneously for nine doses with low-dose cyclophosphamide. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival, correlation of clinical outcome with humoral immune response and Globo H expression, and safety.ResultsOf 349 patients randomized, 348 received study drug. Patients with the following breast cancer subtypes were included: hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2–) (70.4%), triple negative (12.9%), and HER2+ (16.7%), similarly distributed between treatment arms. Median PFS was 7.6 months (95% CI: 6.5–10.9) with AS/OBI-821 (n=224) and 9.2 months (95% CI: 7.3–11.3) with placebo (n=124) (HR=0.96; 95% CI: 0.74–1.25; p=0.77), with no difference by breast cancer subtype. AS/OBI-821 recipients with anti-Globo H IgG titer ≥1:160 had significantly longer median PFS (11.1 months (95% CI: 9.3–17.6)) versus those with titers <1:160 (5.5 months (95% CI: 3.7–5.6); HR=0.52; p<0.0001) and placebo recipients (HR=0.71; p=0.03). Anti-KLH immune responses were similar at week 40 between AS/OBI-821 recipients with anti-Globo IgG titer ≥1:160 and those with anti-Globo IgG titer <1:160. The most common adverse events with AS/OBI-821 were grade 1 or 2 injection site reactions (56.7%; placebo, 8.9%) and fever (20.1%; placebo, 6.5%).ConclusionAS/OBI-821 did not improve PFS in patients with previously treated MBC. However, humoral immune response to Globo H correlated with improved PFS in AS/OBI-821 recipients, leading the way to further marker-driven studies. Treatment was well tolerated.NCT01516307.

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Self-regulation in children is an important thing that needs to be prepared from an early age. Besides affecting children's school readiness, this also makes it easier for children to have good academic achievements. This study aims to determine the influence of moving to the beat of early childhood self-regulation. This research was conducted on kindergarten group B students in East Jakarta. The research method used is a quasi-experiment method with a sample of 20 students. The data collection technique uses observations by analysing paired t-test statistical data. The results of the study explained that there was a significant effect of moving to the beat of early childhood self-regulation. The significance level is 0.000 < 0.05, which means that H0 is rejected and H1 is accepted, this indicates a significant difference between the pre-test and post-test. For further research, it is recommended to look at the influence of other factors on early childhood self-regulation. 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Cancer progression, relapse and resistance are the result of an evolutionary optimization process. Vast intra-tumoral diversity provides the critical substrate for cancer to evolve and adapt to the selective pressures provided by effective therapy. Our previous work has shown that genetically distinct subpopulations compete and mold the genetic makeup of the malignancy (1, 2). Additionally, we have shown that epigenetic changes in cancer may be similar to the process of genetic diversification, in which stochastic trial and error leads to rare fitness enhancing events (3). These studies demonstrate the need to integrate genetic, epigenetic and transcriptional information in the study of cancer evolution, specifically at the single-cell resolution - the atomic unit of somatic evolution. To enable this work, we have developed a single-cell multi-omics toolkit, and apply it to chart the evolutionary history and developmental topographies of normal and malignant blood cells. First, we have applied single-cell multi-omics to chronic lymphocytic leukaemia (CLL), a highly informative model for cancer evolution (4). We applied multiplexed single-cell reduced-representation bisulfite sequencing to healthy B and CLL cells, and demonstrated that epimutations serve as a molecular clock. Heritable epimutation information therefore allows to infer high-resolution lineages with single-cell data, directly in patient samples. CLL tree topography showed earlier branching and longer branch lengths than normal B cell trees. These features reflect rapid drift after malignant transformation and CLL's greater proliferative history. Multi-omic single-cell Integration of methylome sequencing with whole transcriptome and genotyping capture validated tree topology inferred solely on the basis of epimutation information. To examine potential lineage biases during therapy, we profiled serial samples during ibrutinib-associated lymphocytosis, and identified clades of cells that were preferentially expelled from the lymph node after treatment, marked by distinct transcriptional profiles involving TLR pathway activation. The single-cell integration of genetic, epigenetic and transcriptional information thus charts the lineage history of CLL and its evolution with therapy. Second, charting the transcriptomes of clonally mutated cells is challenging in the absence of surface markers that distinguish cancer clones from one another, or from admixed non-neoplastic cells. To tackle this challenge, we developed Genotyping of Transcriptomes (GoT), a technology to integrate genotyping with high-throughput droplet-based single-cell RNA sequencing(5). With GoT we profiled thousands of CD34+ cells from patients myeloproliferative neoplasms to study how somatic mutations corrupt the process of human hematopoiesis. These data allow to superimpose the two differentiation trees; the native wildtype tree and the one corrupted by mutation. High-resolution mapping of malignant versus normal progenitors showed increased fitness with myeloid differentiation with CALR mutation. We identified the unfolded protein response as a predominant outcome of CALR mutations, with dependency on cell identity. Notably, stem cells and more differentiated progenitors show distinct transcriptional programs as a result of somatic mutation, suggesting differential sensitivity to therapeutic targeting. We further extended the GoT toolkit to genotype multiple targets and loci that are distant from transcript ends. Together, these findings reveal that the transcriptional output of somatic mutations in blood neoplasms is dependent on the native cell identity. Landau, D. A., Carter, S. L., Stojanov, P. et al., Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell152, 714-726 (2013).Landau, D. A., Tausch, E., Taylor-Weiner, A. N. et al., Mutations driving CLL and their evolution in progression and relapse. Nature526, 525-530 (2015).Landau, D. A., Clement, K., Ziller, M. J. et al., Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell26, 813-825 (2014).Gaiti, F., Chaligne, R., Gu, H. et al., Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia. Nature569, 576-580 (2019).Nam, A. S., Kim, K. T., Chaligne, R. et al., Somatic mutations and cell identity linked by Genotyping of Transcriptomes. Nature571, 355-360 (2019). Disclosures Landau: Pharmacyclics: Research Funding; Celgene: Research Funding; Illumina Inc: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees.

ObjectivesDomestic epidemiological studies are needed to ascertain the disease burden of bacteraemia in individual countries. This study aimed to evaluate the domestic trends in paediatric and adult bacteraemia in Japan.SettingLaboratory-based surveillance was used to obtain data from 592 hospitals located throughout Japan.ParticipantsThe study was conducted using the results of 827 780 and 3 512 524 blood culture tests obtained from children and adults, respectively, between January 2010 and December 2016.Outcome measuresWe analysed the temporal trends in specific bacterial species (Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Haemophilus influenzae, Listeria monocytogenes and Neisseria meningitidis) detected from the blood cultures of children and adults. For children aged ≤2 years, the data were analysed for each year of age. The proportions of bacteraemia-positive results among the patients were also evaluated.ResultsThe number of bacteraemia-positive samples over the study period was 47,125/827,855 (5.7%) in children and 959,765/3,513,885 (27.3%) in adults. S. pneumoniae was the most frequent cause of bacteraemia in children in 2010. However, after 2011, S. aureus bacteraemia was the most frequent, followed by S. pneumoniae and E. coli. E. coli bacteraemia showed significant increases in both children and adults. In children, S. pneumoniae and H. influenzae bacteraemia decreased from 2010 to 2013. However, S. pneumoniae bacteraemia case numbers stabilised from 2013, whereas H. influenzae bacteraemia cases continued to decrease until 2016.ConclusionThe results suggest that the introduction of the 13-valent pneumococcal conjugate vaccine did not substantially affect disease occurrence. In contrast to the decreasing trends in H. influenzae and S. pneumoniae bacteraemia, S. aureus, E. coli and S. agalactiae bacteraemia showed increasing trends. These findings shed light on recent temporal trends in bacteraemia in both children and adults in Japan.

Child Distance Learning (CDL) during the pandemic has led to an optimal development of children and effective teaching and learning processes in kindergartens. To overcome this, teachers need to apply a teaching approach in accordance with the principles of kindergarten education. In addition, teachers' self-efficacy of their ability to teach is also important for developing children's skills. This study aims to describe the teaching approach and the efficacy of kindergarten teachers during the CDL process and to identify the relationship between the two. The research method used is quantitative through document analysis as a source of data findings. A total of 116 Public Kindergarten (PK) teachers in DKI Jakarta participated in filling out the Classroom Management Scale and Teachers' Sense of Efficacy Scale online. All data were processed using descriptive statistics and correlation. Furthermore, there is a document analysis carried out on the Daily / Weekly Learning Program Design in PK Jakarta. The findings identified that the teaching approach of kindergarten teachers during CDL included only two principles of kindergarten education, namely thematic teaching and developing life skills. Furthermore, PK teachers in the Jakarta area showed low self-efficacy during CDL. The teaching approach and self-efficacy were caused by teachers' unpreparedness in facing challenges during CDL. In addition, other findings indicate that there is a relationship between teaching approaches and teacher self-efficacy. Another CDL model Interventions to increase teacher self-efficacy and the extent to which the relationship between the two variables can be studied further in future studies. Keywords: Early Childhood, Distance Learning, Teaching Approach, Teacher Self-Efficacy References: Agustin, M., & Wahyudin, U. (2011). Penilaian perkembangan anak usia dini. Refika Aditama. 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We present the temperature dependent elastic and ultrasonic properties of sodium borohydride. The second and third order elastic constants of NaBH4 have been computed in the temperature range 0-300K using Coulomb and Born-Mayer potential. The sodium borohydride crystallizes into NaCl-type structure. The computed values of second order elastic constants have been applied to evaluate the temperature dependent mechanical properties such as bulk modulus, shear modulus, tetragonal modulus, Poisson’s ratio and Zener anisotropy factor and ultrasonic velocity to predict futuristic information about sodium borohydride. The fracture to toughness ratio (bulk modulus/shear modulus) in sodium borohydride varied from 1.91 to 1.62, which shows its behavioral change from ductile to brittle on increasing the temperature. Then, ultrasonic Grüneisen parameters have been computed with the use of elastic constants in the temperature regime 100-300K. The obtained results have been discussed in correlation with available experimental and theoretical results. [1] A. Amudhavalli, M. Manikandan, A. Jemmy Cinthia, R. Rajeswarapalanichamy and K. Iyakutti, Z. Naturforsch. A 72 (2017) 321. [2] D.Singh, P.K.Yadawa and S.K.Sahu, Cryogenics 50 (2010) 476. [3] V. Bhalla, D.Singh and S.K.Jain, Int. J. Comput. Mat. Sc. Eng. 5 (2016) 1650012. [4] S. Kaushik, D. Singh and G. Mishra, Asian J. Chem. 24 (2012) 5655. [5] D. Chernyshov, A. Bosak, V. Dmitriev, Y. Filmchuk and H. Hagemann, Phys. Rev. B 78 (2008)172104. [6] H. Hagemann, S. Gomes, G. Renaudin and K. Yvon, J. Alloys Compd. 363 (2004) 126. [7] Y. Filinchuk, D. Chernyshov and V. Dmitriev, Z. Kristallogr. 223 (2008) 649. [8] Z.Xiao Dong, J.Z. Yi, Z. Bo, H. Z. Feng and H.Y. Qing, Chin. Phys. Lett. 28(2011)076201. [9] T. Ghellab, Z. Charifi, H. Baaziz, Ş. Uğur, G. Uğur and F. Soyalp, Phys. Scr. 91 (2016) 045804. [10] S. Bae, S. Gim, H. Kim and K. Hanna, Appl. Catal. B: Environm. 182 (2016) 541. [11] G. Renaudin, S. Gomes, H. Hagemann, L. Keller and K. Yvon, J Alloys Compd. 375 (2004) 98. [12] P. Vajeeston, P. Ravindran, A. Kjekshus and H. Fjellvåg, J Alloys Compd. 387 (2005) 97. [13] S. Orimo, Y. Nakamori, J.R. Eliseo, A. Zuttel and C. M. Jensen, Chem. Rev. 107 (2007) 4111. [14] A. Istek and E. Gonteki, J. Environ. Bio.7 (2009) 951. [15] R. S. Kumar and A.L. Cornelinus, Appl. Phys. Lett. 87 (2005) 261916. [16] E. Kim, R. Kumar, P. F. Weck, A. L. Cornelius, M. Nicol, S. C. Vogel, J. Zhang, M. Hartl, A.C. Stowe, L. Daemen and Y. Zhao, J. Phys. Chem. Lett. B 111 (2007) 13873. [17] K. Brugger, Phys. Rev. 133 (1964) A1611. [18] P.B. Ghate, Phy. Rev. 139 (1965) A1666 [19] S. Mori, Y. Hiki, J. Phys. Soc. Jpn. 45 (1975) 1449. [20] V. Bhalla, R. Kumar, C. Tripathy and D. Singh, Int. J. Mod. Phys. B 27 (2013) 1350116. [21] D. Singh, S. Kaushik, S. Tripathi, V. Bhalla and A. K. Gupta, Arab. J. Sci. Eng. 39 (2014) 485. [22] K. Brugger, Phys. Rev.137 (1965) 1826. [23] W. P. Mason, Physical Acoustics, vol. IIIB, Academic Press, New York, 1965. [24] M.P. Tosi, Solid State Physics, vol. 12, Academic Press, New York, 1965. [25] Y. Nakamori and S. Orimo, J. Alloy Compd.370(2004)271. [26] D. Singh, D.K. Pandey and P.K. Yadawa, Cent. Eur. J. Phys. 7 (2009) 198. [27] V. Bhalla, D. Singh, G. Mishra and M. Wan, J. Pure Appl. Ultrason. 38 (2016)23. [28] D. Singh, S. Kaushik, S.K. Pandey, G. Mishra and V. Bhalla, VNU J. Sc.: Math. Phys. 32(2016)43. [29] J.P.Watt and L. Peselnick, J.Appl. Phys. 51 (1980) 1525. [30] S.F.Pugh, Philos.Mag. 45 (1954) 823. [31] V. Bhalla, D. Singh and S.K. Jain, Int. J. Thermophys. 37(2016)33. [32] V. Bhalla, D. Singh, S.K. Jain and R. Kumar, Pramana- J. Phys. 86 (2016)135.

This article aims to explain how the contestation of social spaces in the lives of the plural society at Lasem it processes dynamically. It is a pattern of space contestation that leads to the affirmation and strengthening of identity or a pattern that leads to the fusion of identities. As a consequence, the first pattern creates social friction or conflict. On the contrary, the second pattern is directed towards acculturation and assimilation of culture which can strengthen social harmony. The important finding of this research is that it can be known the real issue, so that problems related to all parties can be found a solution as well as a resolution. This research also proves that social mechanism preparedness is considered urgent to prevent negative excesses (negative things) from the space contestation. So the space contestation that occurs dynamically proves that the plural society in Lasem has found a valuable experience, namely social resilience in facing all possible emergence of social disintegration.Keywords: contestation, space, social mechanisms and an plural society REFERENCE: Abercrombie, Nicholas, at.all., 2010. Kamus Sosiologi, Terj. Dwi Agus M. Yogyakarta: Pustaka Pelajar. Adhyanggono, GM. ad.all., 2009. Budaya Tionghoa Lasem Dalam Peta Tata Pemukiman, Tradisi, Peran Dan Relasi Gender, dalam Angelina Ika Rahutami (Peny.), ”Kekuatan Lokal Sebagai Roh Pembangunan Jawa Tengah”, Semarang: UNIKA Soegijapranata. Amirudin, 2017. Multikulturalisme dalam Produksi Budaya Seni Batik di Lasem, dalam; ”60 Tahun Antropologi Indonesia; Refleksi Kontribusi Antropologi untuk Indonesia”, Jakarta; Pusat Kajian Antropologi, Departemen Antropologi FISIP UI, 2017. Atabik, Ahmad, 2016. 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Abstract Background: Persistence of leukemia initiating cells (LIC) in T acute lymphoblastic leukemia (T-ALL) results in relapse in 20- 25% of pediatric and over 50% of adult patients1. LIC are characterized by high CD44 expression and low reactive oxygen species (ROS) levels 2, 3. T-ALL LIC maintain low ROS by cystine/glutamate anti-porter complex of which CD44 is a key component 2, 4. CD44 also interacts with microenvironmental components; hyaluronic acid, osteopontin, fibronectin etc. NOTCH1 transcriptionally upregulates CD44/MYC by binding the upstream 'super-enhancer' sites. BRD4, a member of the bromodomain and extra terminal domain (BET) family, is a critical scaffold of super-enhancer complexes that binds acetylated histones (3 and 4) and drives NOTCH1 mediated MYC/CD44 transcription 5, 4, 1. We hypothesized that degradation of BRD4 with hetero-bifunctional PROteolysis TArgeting Chimera (PROTACTM) such as ARV-825, will lead to efficient and sustained downregulation of NOTCH1/MYC /CD44 transcription and disrupt cell intrinsic and extrinsic pathways for persistence of T-ALL LIC. Methods: We confirmed the anti-leukemia effect of ARV-825 (IC50 pico to low nanomolar) against T-ALL cells including early T-cell phenotype (ETP) and Gamma-secretase inhibitor (GSI) resistant T-ALL8. To confirm disruption of NOTCH1/MYC/CD44 axis in-vivo, we specifically tested the impact of BRD4 degradation on NOTCH1 and its target genes including MYC, CD44 and as functional readout, intra-cellular ROS, in a T-ALL/ patient-derived xenograft (PDX) mouse model of disseminated leukemia possessing a constitutively active NOTCH1 mutation. Mass cytometry based proteomic analysis (CyTOF) studies were done to quantitatively assess T-ALL LICs and suppression of NOTCH1-MYC-CD44 axis, and secondary transplantation was carried out into sub-lethally irradiated mouse recipients to functionally evaluate LIC elimination. Results: ARV-825 mediated sustained BRD4 degradation resulted in profound down-regulation of MYC, CD98, CD44 and its variants (CD44v). Moreover, we observed down-regulation of cell intrinsic anti-apoptotic proteins Bcl-2, Bcl-XL. As a functional correlate of down-regulation of CD98/CD44/CD44v (glutathione anti-porter system), flow cytometry confirmed increased intracellular ROS and decreased reduced glutathione (GSH). In a PDX mouse model of human T-ALL, ARV-825 treatment improved survival compared to mice treated with vehicle (P=0.002) (Fig.1). CyTOF analysis of mouse bone marrow cells showed quantitative reduction of phenotypically defined LIC (CD4+CD8+CD7+ CD19- ) 6,7 with down regulation of the NOTCH1-MYC-CD44 axis along with oncogenic molecules (transcription factors Myc and NFkB, cell cycle regulators, activated PI3K/Akt, and anti-apoptotic Bcl2 family proteins) in mice treated with ARV-825 (Fig.2). Finally, secondary transplantation of equal number of human CD45+ cells from Vehicle and ARV-825 treated mice in to NSG mice led to delayed leukemia development and extended survival of mice engrafted from ARV-825 treated mice (Vehicle:38 days Vs ARV-825: 58 days P=0.0001/ Vehicle:36.5 days Vs ARV-825: 50 days P=0.0001) (Fig.3), providing functional confirmation of LIC elimination. Conclusion: Degradation of BRD4 with PROTAC (ARV-825), modulates the NOTCH1/MYC/CD44 axis and has the potential of therapeutically targeting the LIC in T-ALL. Reference Pui CH, Carroll WL, Meshinchi S, Arceci RJ. Journal of clinical oncology 2011; 29(5): 551-565. Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H et al.Cancer cell 2011; 19(3): 387-400. Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN et al.Nature 2009; 458(7239): 780-783. Garcia-Peydro M, Fuentes P, Mosquera M, Garcia-Leon MJ, Alcain J, Rodriguez A et al.The Journal of clinical investigation 2018. doi: 10.1172/JCI92981 Sanchez-Martin M, Ferrando A. Blood 2017; 129(9): 1124-1133. Cox CV, Martin HM, Kearns PR, Virgo P, Evely RS, Blair A. Blood 2007; 109(2): 674-682. Gerby B, Clappier E, Armstrong F, Deswarte C, Calvo J, Poglio S et al.Leukemia 2011; 25(8): 1249-1258. Sujan Piya, Hong Mu, Seemana Bhattacharya, Teresa McQueen, R. Eric Davis, Vivian Ruvolo, Natalia Baran, Yimin Qian, Craig M. Crews, M. James You , Patrick Zweider-McKay, Marina Konopleva, Hagop Kantarjian , Michael Andreeff1, Gautam Borthakur. 59 th Annual Meeting &Exposition, Atlanta GA: December 9-12, 2017. Disclosures Qian: Arvinas LLC Inc: Employment. Raina:Arvinas LLC Inc: Employment. Konopleva:Stemline Therapeutics: Research Funding. Andreeff:Aptose: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Oncoceutics: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Reata: Equity Ownership; SentiBio: Equity Ownership; Oncolyze: Equity Ownership; Eutropics: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Astra Zeneca: Research Funding; Daiichi-Sankyo: Consultancy, Patents & Royalties: MDM2 inhibitor activity patent, Research Funding; United Therapeutics: Patents & Royalties: GD2 inhibition in breast cancer ; Jazz Pharma: Consultancy; Celgene: Consultancy; Amgen: Consultancy, Research Funding.

Taxes are the largest source of state revenue, which is IDR 1,786.4 trillion (82.5%) of the total state revenue of IDR 2,165.1 trillion which is used for public education, health, and infrastructure. However, state revenues experienced a deficit due to the unfulfilled realization of tax revenues. Tax is income for the state, but for companies, tax is a burden that must be paid which reduces the net profit generated. The purpose of this study was to determine the effect of capital intensity, profitability, and financial distress on Tax Avoidance. This study uses secondary data collection techniques with observations through www.idx.co.id, non-probability sampling technique with purposive sampling method. and the analytical method used is multiple linear regression analysis method using SPSS 25.0 program. The results of this study indicate that capital intensity has sufficient evidence of a positive effect on Tax Avoidance. profitability does not have enough evidence of a positive effect on Tax Avoidance. and financial distress does not have enough evidence of a positive effect on Tax Avoidance. Keywords: Tax avoidance, Capital intensity. Profitability, Financial distress References: , W. Y. (2014). Pengaruh Profitabilitas, Leverage, Dan Corporate Governance Terhadap Tax Avoidance (Studi Empiris Pada Perusahaan Manufaktur yang Terdaftar di BEI tahun 2009-2012). Jurnal Akuntansi, 2(3). Altman I Edward. (1968). Financial Ratios, Discriminant Analysis And The Prediction Of Corporate Bankruptcy. The Journal Of Finance, XXIII(4), 589–609. Andriyanto, H. N. (2015). Pengaruh return on assets, leverage, corporate governance, dan sales growth terhadap tax efficience pada perusahaan manufaktur yang terdaftar di BEI Tahun 2009-2012. Anwar, Mokhamad. (2019), Dasar-Dasar Manajemen Keuangan Perusahaan, Jakarta: Prenada Media. Budianti, S., & Curry, K. (2018). Pengaruh profitabilitas, likuiditas, dan capital intensity terhadap penghindaran pajak (Tax Avoidance). In Prosiding Seminar Nasional Cendekiawan (pp. 1205-1209). Bursa Efek Indonesia, diakses pada 20 Desember 2020, https://www.idx.co.id Cahyadi Putra, I., & Merkusiwati, N. (2016). Pengaruh Komisaris Independen, Leverage, Size Dan Capital intensity Ratio Pada Tax Avoidance. E-Jurnal Akuntansi, 17(1), 690-714. Dewi, N. L. P. P., & Noviari, N. (2016). Pengaruh ukuran perusahaan, leverage, profitabilitas dan corporate social responsibility terhadap penghindaran pajak (Tax Avoidance). Sumber, 1(166), 20. Dwiyanti, I. A. I., & Jati, I. K. (2019). Pengaruh Profitabilitas, Capital intensity, dan Inventory Intensity pada Penghindaran Pajak. E-Jurnal Akuntansi, 27(3), 2293-2321. Dyreng, S. D., Hanlon, M., & Maydew, E. L. (2008). Long-run corporate Tax Avoidance. Accounting Review, 83(1), 61–82. Gamayuni, R.R., (2009). Berbagai Alternatif Model Prediksi Kebangkrutan. Jurnal Akuntansi dan Keuangan, 14(1), pp.75-89. Ghozali, Imam. (2016), Aplikasi Analisis Multivariate Dengan Program IBM SPSS 23, Edisi 8, Semarang: Badan Penerbit Universitas Diponegoro. Hanlon, M., & Heitzman, S. (2010). A review of tax research. Journal of accounting and Economics, 50(2-3), 127-178. Hartoto, R. I. (2018). Pengaruh Financial distress, Corporate Governance dan Konservatisme Akuntansi terhadap Tax Avoidance (Studi Empiris pada Perusahaan Perbankan yang Listing di BEI tahun 2015-2017). Hidayat, A. T., & Fitria, E. F. (2018). Pengaruh Capital intensity, Inventory Intensity, Profitabilitas dan Leverage Terhadap Agresivitas Pajak. Eksis: Jurnal Riset Ekonomi dan Bisnis, 13(2), 157-168. Ikatan Akuntansi Indonesia. 2011. PSAK 16 (Revisi 2011) : Aset Tetap. Jakarta : IAI Jensen, M. C., & Meckling, W. H. (1976). Theory of the firm: Managerial behavior, agency costs and ownership structure. Journal of financial economics, 3(4), 305-360. Kasmir. (2016), Pengantar Manajemen Keuangan: Edisi Kedua, Jakarta:Prenada Media Group Kholmi, M. (2010). Akuntabilitas dalam perspektif teori agensi. Journal of Innovation in Business and Economics, 2(02). Kurniasih, T., & Sari, M. M. R. (2013). Pengaruh return on assets, leverage, corporate governance, ukuran perusahaan dan kompensasi rugi fiskal pada Tax Avoidance. Buletin Studi Ekonomi. Meilia, P., & Adnan, A. (2017). Pengaruh Financial distress, Karakteristik Eksekutif, Dan Kompensasi Eksekutif Terhadap Tax Avoidance Pada Perusahaan Jakarta Islamic Index. Jurnal Ilmiah Mahasiswa Ekonomi Akuntansi, 2(4), 84-92. Morris, R. D. (1987). Signalling, agency theory and accounting policy choice. Accounting and business Research, 18(69), 47-56. Nugroho, L., & Anisa, N. (2018). Pengaruh Manajemen Bank Induk, Kualitas Aset, dan Efisiensi terhadap Stabilitas Bank Syariah di Indonesia (Periode Tahun 2013-2017). Inovbiz: Jurnal Inovasi Bisnis, 6(2), 114- 122. Oktamawati, M. (2017). Pengaruh karakter eksekutif, komite audit, ukuran perusahaan, leverage, pertumbuhan penjualan, dan profitabilitas terhadap Tax Avoidance. Jurnal Akuntansi Bisnis, 15(1), 23-40. Putri, V. R., & Putra, B. I. (2017). Pengaruh Leverage, Profitability, Ukuran Perusahaan Dan Proporsi Kepemilikan Institusional Terhadap Tax Avoidance. Jurnal Manajemen Dayasaing, 19(1), 1-11. Rani, P. (2017). Pengaruh Ukuran Perusahaan, Financial distress, Komite Audit, Dan Komisaris Independen Terhadap Tax Avoidance (Studi Empiris pada Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2012-2016). Jurnal akuntansi dan keuangan, 6(2), 221-241. Ratnawati, Juli, & Retno Indah Hernawati. (2016), Dasar-Dasar Perpajakan, Yogyakarta: Deepublish Republik Indonesia. 2007. Undang-Undang Republik Indonesia Nomor 28 Tahun 2007 Tentang Perubahan Atas Undang-Undang Nomor 6 Tahun 1983 Tentang Ketentuan Umum dan Tata Cara Perpajakan. Lembaran RI Tahun 2007, No. 28. Sekretariat Negara. Jakarta Republik Indonesia. 2008. Undang-Undang Indonesia Nomor 36 Tahun 2008 Tentang Perubahan Atas Undang- Undang Nomor 7 Tahun 1983 Tentang Pajak Penghasilan. Lembaran Negara Republik Indonesia, No. 133. Sekretariat Negara. Jakarta Republik Indonesia. 2009. Undang-Undang Indonesia Nomor 16 Tahun 2009 Tentang Penetapan Perpu 5-2008 Tentang Perubahan Keempat UU 6-1983 Tentang Ketentuan Umum Dan Tata Cara Perpajakan Menjadi UU. Lembaran Negara Republik Indonesia, No. 211. Sekretariat Negara. Jakarta Republik Indonesia. 2019. APBN 2019 https://www.kemenkeu.go.id/apbn2019 Richardson, G., Taylor, G., & Lanis, R. (2015). The impact of financial distress on corporate Tax Avoidance spanning the global financial crisis: Evidence from Australia. Economic Modelling, 44, 44-53. 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Purpose Bimetallic composite pipe consists of a corrosion resistance alloy (CRA) layer for corrosion resistance and carbon steel for mechanical properties, which shows a promising prospect of gathering pipeline with its effective-cost and reliable corrosion resistance. However, the corrosion resistance of composite pipe is determined by the quality of its welding gap. This paper aims to investigate the TIG welding gap corrosion resistance of X52/825 metallurgical clad pipe in H2S/CO2 environment. Design/methodology/approach Corrosion tests of X52/825 welding gap were performed in a stimulated gas field solution containing both 1 MPa CO2 and 1.5 MPa H2S at 70°C for 720 h in a self-designed high temperature and high pressure autoclave. The anti-stress corrosion cracking (SCC) performance of X52/825 clad pipe ring root welding gap was investigated in both NACE A solution and the stimulant gas field solution by four point bending testing and constant load test. Then the experiments were rerun in XX high sour gas well. In addition, the alloy diffusion and microstructure characteristics of TIG welding gap were analyzed through scanning electron microscopy and energy dispersive X-ray spectroscopy technologies. Findings The results reveal that the root welding gap is almost not corroded in the stimulant gas field solution, and no micro-cracks were observed by electron microscope. Anti-SCC test results show the root welding gap does not break, indicating a good resistance to environmental-cracking in H2S/CO2 environment. The transition layer can be obviously observed in the root welding zone, and the alloy content of transition layer is diluted. However, the transition layer does not penetrate into the inner of CRA layer, which illustrates its good anti-corrosion performance. Therefore, TIG welding technology can be well used in the welding process of composite pipe. Originality/value This paper may provide theoretical reference for manufacturing and application of clad pipe.

Functional nucleic acid receptors (aptamers) have emerged as effective and robust recognition elements for state-of-the-art biosensors. Analytical readouts from aptamer-based biosensors (whether optical, electrochemical, or otherwise) derive primarily from global-scale conformational changes induced in the aptamer domain by analyte binding. Herein, we describe a unique biosensor design principle that represents a distinct alternative to this paradigm; particularly we demonstrate the ready applicability of this design principle in the de novo creation of electrochemical sensors for a clinical analyte of current interest. The function of the class of biosensors we describe, termed “DNA nano-switches”, is designed to depend on the integrity of duplex DNA-mediated charge transfer between an electrode and a redox label. [1] Thomas, J. M.; Chakraborty, B.; Sen, D.; Yu, H.-Z. J. Am. Chem. Soc. 2012, 134, 13823–13833. [2] Tang, Y.; Ge, B.; Sen, D.; Yu, H.-Z. Chem. Soc. Rev. 2014, 43, 518–529 [3] Ma, F.; Qi, L.; Einarson, O.; Sen, D.; Yu, H.-Z. Anal. Chem. 2019, 91, 8244−8251. Figure 1

Abstract Mechanical alloying of high-purity aluminum and 10 wt.% NiO powders combined with powder vacuum compression and following hot extrusion method was used to produce an Al-NiO composite. Mechanical properties of as-extruded materials as well as the samples annealed at 823 K /6 h, were tested by compression at 293 K - 770 K. High mechanical properties of the material were attributed to the highly refined structure of the samples. It was found that the structure morphology was practically not changed during hot-compression tests. Therefore, the effect of deformation temperature on the hardness of as-deformed samples was very limited. The annealing of samples at 823 K/6 h induced a chemical reaction between NiO-particles and surrounding aluminum matrix. As a result, the development of very fine aluminum oxide and Al3Ni grains was observed.

Digital natives’ generation is inseparable from gadgets, less socializing, lack of creativity and being an individualist. The digital native’s generation wants things that are instant and lack respect for the process. The preoccupation of children with gadgets makes children socially alienated or known as anti-social. Preschool play an important role in the development of the digital native’s generation and in the future can help children use gadgets with parents. As it is known, the digital native’s generation is a kindergarten child. This study aims to determine the role of preschools in helping the use of gadgets in the digital native generation. This study used a descriptive quantitative approach with simple random sampling technique was obtained 25 kindergarten principals in Pekanbaru City. Data was collected in the form of a questionnaire via google form. Data analysis uses percentages and is presented in the tabular form. The results of the study indicate that the role of preschools in the use of gadgets in digital native generation children in Pekanbaru City is included in the low category. Only a few preschools have organized parenting education for parents. There are almost no rules governing children's use of gadgets at home, and few preschools educate children on how to use gadgets properly. It is expected for teachers and preschools to add special programs in the curriculum to provide information about positive gadget use and parenting programs that discuss digital native generation and collaborate with parents to establish rules such as frequency, duration and content of children using gadgets. Keywords: Digital Native, Preschool, Gadgets References: Alia, T., & Irwansyah, I. (2018). Pendampingan orang tua pada anak usia dini dalam penggunaan teknologi digital [parent mentoring of young children in the use of digital technology]. Polyglot: Jurnal Ilmiah, 14(1), 65–78. Allen, K. A., Ryan, T., Gray, D. L., McInerney, D. M., & Waters, L. (2014). Social Media Use and Social Connectedness in Adolescents: The Positives and the Potential Pitfalls. The Australian Educational and Developmental Psychologist, 31(1), 18–31. https://doi.org/10.1017/edp.2014.2 Berlin, A., Törnkvist, L., & Barimani, M. (2016). Content and Presentation of Content in Parental Education Groups in Sweden. The Journal of Perinatal Education, 25(2), 87–96. https://doi.org/10.1891/1058-1243.25.2.87 Chapman, G., & Pellicane, A. (2014). Growing up social: Raising relational kids in a screen-driven world. Moody Publishers. Cho, K.-S., & Lee, J.-M. (2017). Influence of Smartphone Addiction Proneness of Young Children on Problematic Behaviors and Emotional Intelligence. Comput. Hum. Behav., 66(C), 303–311. https://doi.org/10.1016/j.chb.2016.09.063 Coie, J. D., & Dodge, K. A. (1988). Multiple sources of data on social behavior and social status in the school: A cross-age comparison. Child Development, 815–829. Crouch, A. (2017). Tech-Wise Family. Everyday Steps for Putting Technology in Its Proper Place. Baker Books. De Lima, L., & Castronuevo, E. (2016). Perception of parents on children’s use of gadgets. The Bedan Journal of Psychology, II, 26–34. Gani, S. A. (2017). Parenting Digital Natives: Cognitive, Emotional, and Social Developmental Challenges. Guralnick, M. J. (1999). Family and child influences on the peer‐related social competence of young children with developmental delays. Mental Retardation and Developmental Disabilities Research Reviews, 5(1), 21–29. Hosokawa, R., & Katsura, T. (2018). Association between mobile technology use and child adjustment in early elementary school age. PloS One, 13(7), e0199959. Jonathan, L. P., & Andrew, L. F. (2016). Depression in children and adolescents. University of Kansas, Clinical Child Psychology Program. Kabali, H. K., Irigoyen, M. M., Nunez-Davis, R., Budacki, J. G., Mohanty, S. H., Leister, K. P., & Bonner, R. L. (2015). Exposure and Use of Mobile Media Devices by Young Children. PEDIATRICS, 136(6), 1044–1050. https://doi.org/10.1542/peds.2015-2151 Kirschner, P. A., & De Bruyckere, P. (2017). The myths of the digital native and the multitasker. Teaching and Teacher Education, 67, 135–142. https://doi.org/10.1016/j.tate.2017.06.001 Kurniawan, A. R., Chan, F., Sargandi, M., Yolanda, S., Karomah, R., Setianingtyas, W., & Irani, S. (2019). Kebijakan Sekolah Dalam Penggunaan Gadget di Sekolah Dasar [School Policy on the Use of Gadgets in Elementary Schools]. Jurnal Tunas Pendidikan, 2(1), 72–81. Martin, D. J. (2001). Constructing Early Childhood Science. Delmar Thomson Learning, Inc,. Morrongiello, B. A., McArthur, B. A., Goodman, S., & Bell, M. M. (2015). Don’t touch the gadget because it’s hot! Mothers’ and children’s behavior in the presence of a contrived hazard at home: Implications for supervising children. Journal of Pediatric Psychology, 40 1, 85–95. Mueller, S., Remaud, H., & Chabin, Y. (2011). How strong and generalisable is the Generation Y effect? A cross‐cultural study for wine. International Journal of Wine Business Research, 23(2), 125–144. https://doi.org/10.1108/17511061111142990 NAEYC. (2012). Technology and interactive media as tools in early childhood programs serving children from birth through age 8. National Institute for Educational Policy Research. (2014). Zenkoku Gakuryoku Gakusyu Jyokyo Cyosa [Japanese]. Nielsen Company. (2009). Television, Internet, and mobile usage in the U.S.: A2/M2 Three Screen Report. Nielsen Company. Nielsen, M. (2012). Imitation, pretend play, and childhood: Essential elements in the evolution of human culture? Journal of Comparative Psychology, 126(2), 170–181. https://doi.org/10.1037/a0025168 Novianti, R., Febrialismanto, F., Puspitasari, E., & Hukmi, H. (2020). Meningkatkan pengetahuan orang tua dalam mendidik anak di era digital di Kecamatan Koto Gasib Kabupaten Siak Provinsi Riau [Increasing parental knowledge in educating children in the digital era in Koto Gasib Sub-district, Siak Regency, Riau Province]. Riau Journal of Empowerment, 3(3), 183–190. https://doi.org/10.31258/raje.3.3.183-190 Novianti, R., & Garzia, M. (2020). Penggunaan Gadget pada Anak; Tantangan Baru Orang Tua Milenial[Use of Gadgets in Children; Millennial Parents' New Challenge]. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 4(2), 1000–1010. Pediatrics, A. A. O. (2016). American Academy of Paediatrics announces new recommendations for children’s media use. Advocacy & Policy. Radesky, J. S., & Christakis, D. A. (2016). Increased Screen Time: Implications for Early Childhood Development and Behaviour. Paediatric Clinics of North America, 63(5), 827–839. https://doi.org/10.1016/j.pcl.2016.06.006 Ransdell, S., Kent, B., Gaillard-Kenney, S., & Long, J. (2011). Digital immigrants fare better than digital natives due to social reliance: Digital immigrants and social reliance. British Journal of Educational Technology, 42(6), 931–938. https://doi.org/10.1111/j.1467-8535.2010.01137.x Rideout, V., &. Robb, M. B., & Robb, M. B. (2020). The commonsense census: Media use by kids aged zero to eight. Common Sense Media. Scott, F. L. (2021). Family mediation of preschool children’s digital media practices at home. Learning, Media, and Technology, 1–16. https://doi.org/10.1080/17439884.2021.1960859 Setianingsih, S. (2018). Dampak penggunaan gadget pada anak usia prasekolah dapat meningkatan resiko gangguan pemusatan perhatian dan hiperaktivitas [The impact of using gadgets on preschool-aged children can increase the risk of attention deficit disorder and hyperactivity]. Gaster, 16(2), 191–205. Sharkins, K. A., Newton, A. B., Albaiz, N. E. A., & Ernest, J. M. (2016). Preschool Children’s Exposure to Media, Technology, and Screen Time: Perspectives of Caregivers from Three Early Childcare Settings. Early Childhood Education Journal, 44(5), 437–444. https://doi.org/10.1007/s10643-015-0732-3 Sheedy, A. J., Brent, J., Dally, K., Ray, K., & Lane, A. E. (2021). Handwriting Readiness among Digital Native Kindergarten Students. Physical & Occupational Therapy In Pediatrics, 41(6), 655–669. https://doi.org/10.1080/01942638.2021.1912247 Steiner-Adair, C., & Barker, T. H. (2013). The Big Disconnect (1st ed.). Harper Collins. Strasburger, V. C., Jordan, A. B., & Donnerstein, E. (2010). Health effects of media on children and adolescents. Pediatrics, 125(4), 756–767. Sugiyono. (2017a). Statistika untuk Penelitian[Statistics for Research]. Alfabeta. Sugiyono, P. (2017b). Metode Penelitian Pendidikan: Pendekatan Kuantitatif, Kualitatif, R&D [Educational Research Methods: Quantitative, Qualitative, R&D Approach]. Cetakan Ke-25. Bandung: CV Alfabeta. Suhana, M. 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Abstract The artificial insemination (AI) technique is an essential tool in goat breeding programs, since it increases the efficiency of sire genetic evaluation and the extension of genetic improvements; at the same time, it enables control of parturition dates with a view to meeting market demands. The objective of this study was to determine the fecundity rate according to the mode of semen preservation before artificial insemination. The percentage of kidding was influenced by the duration of storage: 3 h = 88%; 14 h =821%.

Abstract An Al(Mg)-NiO composite was manufactured using combined mechanical alloying (MA) and powder consolidation methods that yielded well-consolidated and very-fine grained bulk material. Compression tests at 293 K - 773 K revealed high mechanical properties of the material. Preliminary annealing at 823 K/6 h was found to result in the flow stress reduction at 573 K - 773 K. However, the effect of preliminary annealing on the flow stress value was relatively low for Al(Mg)-NiO if comparing to similar tests performed for the Al-NiO composite. Structural observations revealed very-fine grained structure of both as-extruded and annealed Al(Mg)-NiO composites. The chemical reaction between the composite matrix and reinforcements (NiO) at sufficiently high temperatures resulted in fine grains and spinel-type particles’ development. With respect to the similarly produced Al-NiO composite, a magnesium addition was found to intensify chemical reaction between Al(Mg)-based matrix and NiO particles. As result, fine Al3Ni particles were observed in both hot-extruded material and Al(Mg)-NiO samples annealed at 823 K/6 h.

e4176066In this paper we present a discussion about the implications of the theory of mental models in the teaching and learning process in Chemistry, with the purpose of discussing the use of stop motion animation as a data collection instrument to investigate the students' mental representations about chemical concepts, especially about their dynamic character. To achieve the objectives mentioned in the present work, we seek to relate the theory of mental models and their implications for the teaching and learning processes in chemistry, with the proposal of the triangulation of the three different representational levels of Chemistry (submicroscopic, symbolic and macroscopic), which are necessary to understand this Science. It is also noteworthy that this articulation was based on the main difficulties associated with the teaching and learning processes in Chemistry and was thought of the particularity involving the dynamics of the atomic-molecular level. The discussions carried out involving the different references used allowed us to discuss the potentialities associated with the use of stop motion as an instrument for investigating mental models on chemical concepts, highlighting the fact that it is a technique that is easy to apply, low cost and that allows the dynamic representation of chemical phenomena considering the submicroscopic level.ResumoNo presente trabalho apresentamos uma discussão acerca das implicações da teoria dos modelos mentais nos processos de ensino e aprendizagem em Química, com a finalidade de discorrer sobre o uso de animação em stop motion como um instrumento de coleta de dados para se investigar as representações mentais dos sujeitos sobre conceitos químicos, em especial sobre seu caráter dinâmico. Para atingir os objetivos mencionados no presente trabalho, buscamos relacionar a teoria dos modelos mentais e suas implicações para os processos de ensino e aprendizagem em Química, com a proposta da triangulação dos três diferentes níveis representacionais da Química (submicroscópico, simbólico e macroscópico), que são necessários para a compreensão dessa Ciência. Destacamos também, que tal articulação foi pautada nas principais dificuldades associadas aos processos de ensino e aprendizagem em Química e pensada na particularidade envolvendo a dinamicidade do nível atômico-molecular. As discussões realizadas envolvendo os diferentes referenciais utilizados nos possibilitaram discutir sobre as potencialidades associadas ao uso do stop motion como um instrumento de investigação dos modelos mentais sobre conceitos químicos, em destaque para o fato de se tratar de uma técnica de fácil aplicação, de baixo custo e que permite a representação dinâmica pelos alunos dos fenômenos químicos considerando o nível submicroscópico.Palavras-chave: Pesquisa e Educação, Tecnologia e Educação, Psicologia Cognitiva, Avaliação da Aprendizagem.Keywords: Educational Research, Educational Technology, Cognitive Psychology, Evaluation methods.ReferencesBACHELARD, G. A formação do espírito científico. Rio de Janeiro: Contraponto, 1996.BORGES, A. T. Como evoluem os modelos mentais. Ensaio Pesquisa em Educação em Ciência, Belo Horizonte. v. 1, n.1. jan-jun. 1999. p. 66-92.BUNGE, M. Teoria e realidade. São Paulo: Perspectiva, 1974.CUTRERA, G; STIPCICH, S. El triplete químico. 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Electrochemical double-layer capacitors (EDLCs), as a major type of energy storage devices besides rechargeable batteries such as lithium-ion batteries, holds excellent properties such as high power density and ultra-long cycling stability[1-3]; however, its fast self-discharge process has become the major issue that impedes its development and application. Even though research on EDLCs’ self-discharge has demonstrated that the fast self-discharge rate can be tuned even repressed through modifying certain structural properties of electrodes or electrolytes[4-9], to the end of realizing full control over the self-discharge process requires unveiling the fundamental relation between structural parameters (i.e., the pore structure, the surface functionalities, the electrolytic ion size and shape, and etc.) and the self-discharge performance. Carbon, due to its superior chemical stability, high surface area, natural abundance, etc.[4,10], has become one of the main types of electrode materials under extensive research interest for developing advanced EDLCs. Herein, we focus on tuning the pore size, one of the major structural properties of carbon materials relating to its electrochemical performance, to study its effects on self-discharge process and to learn how to construct the optimal pore structure with respect to certain application requirements. In this work, porous carbon materials with designed pore structure are prepared via soft-template method to analyse the self-discharge performance. Through investigating the effects of pore size, as the single variable, on the self-discharge process, as well as on the micro-electrochemical process on the electrode/electrolyte interface, underlying mechanism between pore size and the self-discharge performance has been constructed. These findings should provide guidance on how to locate the optimal pore size for a chosen electrolyte and to realize control over self-discharge, which will serve as solid references for designing the next-generation EDLCs with high performance and controllable self-discharge rates. Reference [1] X. Chen, R. Paul, L. Dai, Natl. Sci. Rev., 2017, 4(3), 453-489. [2] G. Wang, L. Zhang, J. Zhang, Chem. Soc. Rev ., 2012, 41, 797-828. [3] Y. Liu, Y. Shen, L. Sun, J. Li, C. Liu, W. Ren, F. Li, L. Gao, J. Chen, F. Liu, Y. Sun, N. Tang, H. Cheng, Y. Du, Nat. Commun., 2016, 7, 10921. [4] Q. Zhang, C. Cai, J.W. Qin, B.Q. Wei, Nano Energy., 2014, 4, 14-22. [5] T. Tevi, H. Yaghoubi, J. Wang, A. Takshi, J. Power Sources., 2013, 241, 589-596. [6] L. Chen, H. Bai, Z. Huang, L. Li, Energy Environ. Sci., 2014, 7, 1750-1759. [7] G. Shul, D. Bélanger, Phys. Chem. Chem. Phys., 2016, 18, 19137-19145. [8] M. Xia, J. Nie, Z. Zhang, X. Lu, Z.L. Wang, Nano Energy., 2018, 47, 43-50. [9] J. Menzel, E. Frackowiak, K. Fic, Electrochimica Acta, 2020, 332, 135435. [10] D.P. Dubal, O. Ayyad, V. Ruiz, P. Gomez-Romero, Chem. Soc. Rev., 2015, 44, 1777–1790. Figure 1

ABSTRACT The purpose of this study was to analyze the short-term and long-term relationship between the Islamic capital markets of 5 selected countries in the Covid-19 era. This study used a quantitative approach using weekly secondary data from January 2020 to December 2022. The data analysis model used Vector Auto Regression (VAR) analysis. The results of this study show that in the short term, variants in the capital market will change due to shocks in other ASEAN Islamic capital markets, but short-term deviations in the Islamic capital market will adjust in the long term. meanwhile, in the long run, Islamic capital markets in ASEAN countries that were tested, have integrated despite the occurrence of a health crisis that also has an impact on the financial crisis. This provides an opportunity for investors to mitigate risks and increase profit margins, especially in Islamic stock exchanges in ASEAN countries. On the other hand, this research allows investors to reformulate a more diversified portfolio after the Covid-19 pandemic. Keywords: Integration, Islamic Capital Market, ASEAN, Covid 19 ABSTRAK Tujuan dari penelitian ini adalah untuk menganalisis hubungan jangka pendek dan jangka panjang antara pasar modal syariah 5 negara terpilih di era Covid-19. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan data sekunder mingguan januari 2020 sampai dengan desember 2022. Model analisis data menggunakan analisis Vector Auto Regression (VAR). Hasil penelitian ini menunjukkan bahwa dalam jangka pendek, varian di pasar modal akan berubah karena guncangan di pasar modal syariah ASEAN lainnya, namun penyimpangan jangka pendek di pasar modal syariah akan menyesuaikan dalam jangka panjang. sementara dalam jangka panjang, pasar modal syariah di negara-negara ASEAN yang teruji, memiliki integrasi meskipun terjadi krisis kesehatan yang juga berdampak pada krisis keuangan. Hal ini memberikan suatu kesempatan bagi para investor untuk memitigasi risiko dan memperbesar margin keuntungan terutama di bursa saham syariah negara ASEAN. Disisi lain, dengan adanya penelitian ini memungkinkan membantu para investor untuk merumuskan kembali portofolio yang lebih terdiversifikasi setelah terjadinya pandemi covid-19. Kata Kunci: Integrasi, Pasar Modal Syariah, ASEAN, Covid 19 REFERENCES Abd. Majid, M. S. (2018). Who Co-Moves The Islamic Stock Market of Indonesia -The US, The UK, or Japan? Al-Iqtishad: Jurnal Ilmu Ekonomi Syariah, 10(2), 267–284. doi:10.15408/aiq.v10i2.7288 Abdul Karim, B., & Abdul-Rahman, A. (2020). Market integration in asean-5: Evidence of Islamic and conventional stock markets. Polish Journal of Management Studies, 21(1), 186–198. doi:10.17512/pjms.2020.21.1.14 Abdulkarim, F. M., Akinlaso, M. I., Hamid, B. A., & Ali, H. S. (2020). The nexus between oil price and Islamic stock markets in Africa: A wavelet and Multivariate-GARCH approach. 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Language skills are essential for early childhood, being able to speak clearly and process speech sounds, understand others, express ideas, and interact with others are the building blocks for a child's development. Therefore, this study will examine the effect of the Inside Outside Circle (IOC) instructional strategies with media images on children's language skills. This research is a quasi-experimental design with a posttest only and using a control group. The sample in this study were children in two kindergartens in the village of Banjar Tegal. Data analysis in this study was carried out by quantitative descriptive methods using t-test analysis techniques. The results of this study in kindergarten students in Banjar Tegal Village show that there is an influence of the IOC learning model with picture media on children's language skills (tcount = 6.28> ttable = 2.00). This shows that language skills achieved by groups of children participating in learning with the IOC model with drawing media are better than groups of children who attend learning without the IOC model. The implication is that further research is expected to develop other aspects of child devel- opment through the IOC model. Keywords: Children Language skills, Image media, Inside-Outside Circle Instructional Strategies Reference: Afrida, Ni., & Mahriza, R. (2019). Visual and Cognitive Media : The Language Acquisition of Children With Dyslexia in Aceh. IJLRES - International Journal on Language , Research and Education Studies, 3(1), 112–126. https://doi.org/10.30575/2017/IJLRES-2019010409 Al Otaiba, S., & Fuchs, D. (2006). Who are the young children for whom best practices in reading are ineffective? An experimental and longitudinal study. Journal of Learning Disabilities, 39(5), 414–431. https://doi.org/10.1177/00222194060390050401 Asrifan, A. (2015). 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Early childhood education as the main foundation of one's education is determined by the quality of teachers who can be seen through the performance of teachers and teachers, so the discourse of professional development is important. This study aims to determine how the performance of superior early childhood teachers and performance measurement as performance standards for outstanding teachers. Qualitative research is carried out with a psychological approach that is carried out directly on the object under study, to obtain data relating to aspects of teacher performance so that increased performance becomes an example for other teachers. Research data collection techniques using interviews, documentation, and observation. The results showed that the performance of outstanding early childhood teachers always tried to hone and control themselves by participating in outstanding teacher competitions to monitor their professional condition and performance. Early childhood teachers who have extraordinary grades also have strong scientific insight, understand learning, have broad social insights, are positive about their work, and show work performance according to the required performance criteria. The teacher's performance in the extraordinary category is the success and ability of the teacher in carrying out various learning tasks. Measuring the performance of early childhood teachers with achievement has two tasks as measurement standards, tasks related to the learning process and tasks related to structuring and planning learning tasks. Referring to these two tasks, there are three main criteria related to teacher performance in early childhood teacher professional development literacy, namely processes, teacher characteristics, and outcomes or products (changes in student attitudes). In the learning process, the performance of early childhood teachers who excel can be seen from the quality of work carried out related to professional teacher learning activities. Keywords: Early Childhood Education, Outstanding Educator Performance, Professional Development References: Abry, T. (2015). Preschool and kindergarten teachers’ beliefs about early school competencies: Misalignment matters for kindergarten adjustment. Early Childhood Research Quarterly, 11. Algozzine, B., Babb, J., Algozzine, K., Mraz, M., Kissel, B., Spano, S., & Foxworth, K. (2011). Classroom Effects of an Early Childhood Educator Professional Development Partnership. NHSA Dialog, 14(4), 246–262. https://doi.org/10.1080/15240754.2011.613125 Anders, Y. (2015). Literature Review on Pedagogy. 62. Ary, D., Jacobs, L. C., Razavieh, A., & Ary, D. (2010). Introduction to research in education (8th ed). Wadsworth. Bukoye, R. O. (2019). Utilization of Instruction Materials as Tools for Effective Academic Performance of Students: Implications for Counselling. Proceedings, 2(21), 1395. https://doi.org/10.3390/proceedings2211395 Choo, K. K. (2010). The Shaping of Childcare and Preschool Education in Singapore: From Separatism to Collaboration. 4, 12. Driscoll, K. C., & Pianta, R. C. (2010). Banking Time in Head Start: Early Efficacy of an Intervention Designed to Promote Supportive Teacher–Child Relationships. 29. ECE – TPEs and CAPEs. (2019). California Early Childhood Education Teaching and Administrator Performance Expectations. Commission on Teacher Credentialing. Eggum-Wilkens, N. D. (2014). Playing with others: Head Start children’s peer play and relations with kindergarten school competence. Early Childhood Research Quarterly, 12. Goodfellow, J. (2001). Wise Practice: The Need to Move beyond Best Practice in Early Childhood Education. Australasian Journal of Early Childhood, 26(3), 1–6. https://doi.org/10.1177/183693910102600302 Guskey, T. R. (2001). Helping Standards Make the GRADE. 10. Hamre, B. K., & Pianta, R. C. (2005). Can Instructional and Emotional Support in the First-Grade Classroom Make a Difference for Children at Risk of School Failure? Child Development, 76(5), 949–967. https://doi.org/10.1111/j.1467-8624.2005.00889.x Han, J., Luo, X., & Luo, H. (2021). Development and Validation of Preschool Teachers’ Caring Behaviour Questionnaire and Its Internal Mechanism with Work Performance. Open Journal of Social Sciences, 25. Hargreaves, A. (2000). Mixed emotions: Teachers’ perceptions of their interactions with students. Teaching and Teacher Education, 16(8), 811–826. https://doi.org/10.1016/S0742-051X(00)00028-7 Harwood, D., Klopper, A., Osanyin, A., & Vanderlee, M.-L. (2013). ‘It’s more than care’: Early childhood educators’ concepts of professionalism. Early Years, 33(1), 4–17. https://doi.org/10.1080/09575146.2012.667394 Hedges, H., & Cooper, M. (2016). Inquiring minds: Theorizing children’s interests. Journal of Curriculum Studies, 48(3), 303–322. https://doi.org/10.1080/00220272.2015.1109711 Hughes, A., & Menmuir, J. (2002). Being a Student on a Part-time Early Years Degree. Early Years, 22(2), 147–161. https://doi.org/10.1080/09575140220151486 Hur, E., Jeon, L., & Buettner, C. K. (2016). Preschool Teachers’ Child-Centered Beliefs: Direct and Indirect Associations with Work Climate and Job-Related Wellbeing. Child & Youth Care Forum, 45(3), 451–465. https://doi.org/10.1007/s10566-015-9338-6 Ishimine, K., Tayler, C., & Bennett, J. (2010). Quality and Early Childhood Education and Care: A Policy Initiative for the 21st Century. International Journal of Child Care and Education Policy, 4(2), 67–80. https://doi.org/10.1007/2288-6729-4-2-67 Katz, L. G. (2015). Distinctions between academic versus intellectual goals for young children. 4. Kim, K. (2018). Early childhood teachers’ work and technology in an era of assessment. 14. https://doi.org/10.1080/1350293X.2018.1533709 Molla, T., & Nolan, A. (2019). Identifying professional functionings of early childhood educators. Professional Development in Education, 45(4), 551–566. https://doi.org/10.1080/19415257.2018.1449006 Moyles, J. (2001). Passion, Paradox and Professionalism in Early Years Education. Early Years, 21(2), 81–95. https://doi.org/10.1080/09575140124792 Nolan, A., & Molla, T. (2018). Teacher professional learning as a social practice: An Australian case. International Studies in Sociology of Education, 27(4), 352–374. https://doi.org/10.1080/09620214.2017.1321968 Oberhuemer, P. (2005). Conceptualising the early childhood pedagogue: Policy approaches and issues of professionalism. European Early Childhood Education Research Journal, 13(1), 5–16. https://doi.org/10.1080/13502930585209521 Osgood, J. (2004). Time to Get Down to Business?: The Responses of Early Years Practitioners to Entrepreneurial Approaches to Professionalism. Journal of Early Childhood Research, 2(1), 5–24. https://doi.org/10.1177/1476718X0421001 Osgood, J. (2007). Professionalism and performativity: The feminist challenge facing early years practitioners. 14. https://doi.org/doi: 10.1080/09575140600759997. Osgood, J. (2009). Childcare workforce reform in England and ‘the early years professional’: A critical discourse analysis. Journal of Education Policy, 24(6), 733–751. https://doi.org/10.1080/02680930903244557 Pianta, R. C. (2016). Teacher–Student Interactions. Policy Insights from the Behavioral and Brain Sciences, 3(1), 8. https://doi.org/DOI: 10.1177/2372732215622457 Piotrkowski, C. S., Botsko, M., & Matthews, E. (2001). Parents’ and Teachers’ Beliefs About Children’s School Readiness in a High-Need Community. 22. Rodgers, C. R., & Raider‐Roth, M. B. (2006). Presence in teaching. Teachers and Teaching, 12(3), 265–287. https://doi.org/10.1080/13450600500467548 Sheridan, S. M., Edwards, C. P., & Marvin, C. A. (2009). Professional Development in Early Childhood Programs: Process Issues and Research Needs. 26. Thomas, D., & Brown, J. S. (2011). Cultivating the Imagination for A World of Constant Change. 37. Urban, M. (2008). Dealing with uncertainty: Challenges and possibilities for the early childhood profession. European Early Childhood Education Research Journal, 16(2), 135–152. https://doi.org/10.1080/13502930802141584 Vartiainen, H., Leinonen, T., & Nissinen, S. (2019). Connected learning with media tools in kindergarten: An illustrative case. Educational Media International, 56(3), 233–249. https://doi.org/10.1080/09523987.2019.1669877 Walker, A., & Qian, H. (2018). 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Postprandial hyperglycemia plays an important role in the development of type 2 diabetes. Inhibition of alpha-amylase was led to a delay in breaks down of starch and glycogen and prevented a rapid rise in blood sugar. Alpha-amylase was isolated by gel filtration chromatography Sephadex G-75 from bovine pancreas. Then, total methanolic extracts of plants were prepared and IC50 values of extracts on alpha-amylase were obtained and compared with acarbose IC50. The polyphenolic content of extracts and antioxidant capacity were determined by Folin-Ciocalteu test and DPPH test, respectively. The specific activity of alpha-amylase was 48.2 U/mg. For inhibition of alpha-amylase, IC50 values of H. persicum, Z. jujuba, and acarbose were 307, 827, and 113 μg/ml, respectively. For inhibition of DPPH radical, IC50 values of extracts were 235 and 701 μg/ml. Total phenolic contents of methanol extracts were 73.8±3.2 and 44.2±1.8 μg tannic acid equivalent/mg extract. Acarbose causes gastrointestinal symptoms and liver toxicity, but H. persicum and Z. jujuba decrease these side effects and prevent gastrointestinal disorders. Due to the high polyphenolic content and antioxidant capacity of these plants and significant inhibitory effect of the plants on alpha-amylase, these plants can be proposed for treatment of diabetic patients.

e23078 Background: We examined epidemiological trends and patient characteristics including age, race, incidence and survival in female breast cancer (BC) using the updated largest population-based cancer registry in the US. Methods: Female patients diagnosed with breast cancer between 2010-2020 were identified in SEER registries. We incorporated SEER 22 registries to calculate incidence, race, disease characteristics and overall survival. Results: Incidence Rate (IR) for BC has been increasing by 0.4%/year and mortality rates (MR) have declined 1.3%/year during 2010-2020 for all patients. 5-&10-year overall survival (OS) has increased by 0.1 and 0.2% respectively. For ages < 50 years,IR increased by 0.9% vs 0.4% for those 65 and above. No statistically significant change in IR was noted for ages 50-64y. For ages < 50 and between 50-64y, MR overall decreased by 1.4%/y each vs by 1.1%/y for those 65+. However, no statistically significant change in MR was noted for women < 50y between 2016-2020. IR increased by 1.6%/year in Asian/Pacific Islanders (API), 1.1%/y in Hispanics (H),0.6% in Blacks (B) and 0.4% in Non-Hispanic White (NHW) and. MR declined 1.5%/y in B, 1.2%/y NHW, 1% H and by 0.3% in API.IR for HR+/HER2- BC increased by 1.9%. No statistically significant change in IR was noted for triple negative or HER2+ only BC. IR for HR+/HER2+ BC increased overall during this time period by 1.4%; however, IR increased by 3.6% between 2010-2016 and decreased by 2.9% after 2016. 5y-OS was 91% in 2015 (CI 90.7-91.3) for all women, improved from 89.7% in 2010 (CI 89.4-90.0). 5yOS was 90.7% vs 91.3% vs 91.0% for < 50, 50-64 and 65+ age groups. When compared to 2010 and 2005, 5yOS was consistently improved across all age groups. 5yOS in B was 82.5% (CI 81.6-83.4) vs 92.1% (CI 91.8-92.5) in NHW. This discrepancy existed across all age groups: for < 50, 50-64 and 65+y, 91.6 vs 92.5 vs 92.1% for W women vs 82.7 vs 82.9 vs 82.0% for their B counterparts. 5yOS for localized, regional and distant disease at diagnosis for all women was 99.2%, 86.7% and 31.5%. 5yOS for B vs W females was 95.9 vs 99.7% localized, 78.3 vs 88% regional and 23.4 vs 33.0% for distant disease. Conclusions: Epidemiological trends show improved OS in BC among all groups. B females and patients with advanced stage have worse outcomes. Greater increase in IR was noted for women < 50 years of age. Greater IR increase was noted in H and API women but decline in MR was smallest in these women. IR for HR/HER2 + BC increased initially followed by a decline. 5r survival in B women was lower compared to NHW across all age groups. 5y survival for B women was worse, irrespective of stage at diagnosis. We hypothesize underlying disease biology may be a potential factor for worse outcome in B women.

ABSTRACT: Teacher performance has been the focus of educational policy reforms in recent decades for the professional development of teachers. The purpose of this study was to determine the effect of teaching experience and peer teaching skills on basic training on ECE teacher performance. This research uses ex-post facto quantitative method of comparative analysis and design by level. The population is all ECE teachers who attend basic-level education and training in Tangerang Regency, totaling 3358 people consisting of 116 male teachers and 3,242 female teachers. Data collection techniques using a questionnaire with data analysis include descriptive analysis. Requirements test analysis and inferential analysis. The results show that there are differences in the performance of ECE teachers between teachers with more than five years of teaching experience and less than five years, in the group of ECE teachers with high peer teaching skills and low peer teaching skills. The implication of this research is that it is hoped that various parties will become more active in aligning ECE teacher training so that it can improve the performance of ECE teachers. Keywords: teaching experience, peer teaching ability, tiered basic training, ECE teacher performance References: Adeyemi, T. (2008). Influence of Teachers’ Teaching Experience on Students’ Learning Outcomes in Secondary Schools in Ondo State, Nigeria. African Journal of Educational Studies in Mathematics and Sciences, 5(1), 9–19. https://doi.org/10.4314/ajesms.v5i1.38609 Ahmad, N. J., Ishak, N. A., Samsudin, M. A., Meylani, V., & Said, H. M. (2019). Pre-service science teachers in international teaching practicum: Reflection of the experience. Jurnal Pendidikan IPA Indonesia, 8(3), 308–316. https://doi.org/10.15294/jpii.v8i3.18907 Andrin, G. R., Etcuban, J. O., Watin, A. K. O., Maluya, R., Rocha, E. D. V, & Maulit, A. A. (2017). 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Micro, Small and Medium Enterprises (MSMEs) have an important role in increasing economic growth and public welfare, while Islamic financial literacy on products and services is currently an important factor in encouraging performance improvement. The purpose of this study is to determine islamic financial literacy whether it affects the performance and sustainability of MSMEs in Soreang Parepare District. The type of research used is quantitative. The sample of this study was 35 MSMEs in Parepare. Data analysis used descriptive statistics and simple regression. The results of this study found that financial literacy has a positive effect on the performance of MSMEs. These results indicate that financial performance is determined by the level of financial literacy. Financial literacy helps business owners to acquire the financial knowledge and skills necessary for them to make business plans, start financial plans and make strategic investment decisions. Increasing knowledge encourages them to innovate performance. Thus, performance continues to improve. REFERENCES Abbas, A. (2019). Analisis laporan keuangan perbankan syariah. Abbas, A., & Arizah, A. (2019). Marketability, profitability, and profit-loss sharing: evidence from sharia banking in Indonesia. Asian Journal of Accounting Research. Arfan Ikhsan,2014. “Metodologi penelitian bisnis untuk Akuntansi dan Manajemen”, (Bandung Cita pustaka Media) Diana Djuwita dan Ayus Ahmad Yusuf (2018) , “Tingkat Literasi Keuangan Syariah Di Kalangan UMKM Dan Dampaknya Terhadap Perkembangan Usaha”Al.Amwal Vol. 10 No.1 ,hal, 109. Dwitya Ariwibawa (2016), “Pengaruh literasi keuangan terhadap kinerja dan keberlangsungan UMKM Di Jawa Tengah”, Vol. 20 No. 1, h 4. Frihatni, A. A., Sudirman, I., & Mandacan, F. (2022). Dampak Pandemi COVID-19 terhadap Kinerja UMKM dan Strategi Bisnisnya: Studi Kasus UMKM Irrenuang Parepare di Indonesia. Jurnal Akuntansi dan Pajak, 22(2), 759-763. Rachma Fitriati. “ Menguak Daya Saing UMKM Industri Kreatif: Sebuah Riset Tindakan Berbasis Soft System Methodology” Jakarta:Yayasan Pustaka Rahayu,2017. “Pengaruh Literasi Keuangan Terhadap Kinerja dan Keberlangsungan UMKM Di Kota Surabaya”, Jurnal Ilmu Manajemen, Vol. 5 No. 3, h. 4 Rahim, et.al, (2016) Islamic Literasi Keuangan and Its Determinants among University Student:An Exploratory Factor Analysis (International Journal of Economics and Financial Issues, 6 Rayyani, W. O., Arizah, A., & Abbas, A. (2019). The Coaching Assistance of Preparing the Financial Statements Based on Integrated Sak of EMKM [Asistensi Pembinaan Penyusunan Laporan Keuangan Berbasis SAK EMKM yang Terintegrasi]. Proceeding of Community Development, 2, 818-824. Rochmi Widayanti, Ratna Damayanti, FithriaMarwanti. (2017). Pengaruh Financial Literacy Terhadap Keberlangsungan Usaha (Business Susrainability) pada UMKM Desa Jatisari, Vol. 18, No. 2, Oktober Sugiyono. (2010) Metode Penelitian Pendidikan pendekatan kuantitatif, kualitatif, dan R&D, (Bandung: Alfabeta) Surnadi Suryabrata. (2005). Metodologi Penelitian, (Jakarta:PT raja gafindo Persada) Wicaksono. (2015). “Pengaruh Financial Literacy terhadap perilaku pembayaran kartu kredit pada karyawan Di Surabaya”, Finesta, Vol. 3, No. 1, h. 85-90

Rapid urbanization rates impact significantly on the nature of Land Cover patterns of the environment, which has been evident in the depletion of vegetal reserves and in general modifying the human climatic systems (Henderson, et al., 2017; Kumar, Masago, Mishra, & Fukushi, 2018; Luo and Lau, 2017). This study explores remote sensing classification technique and other auxiliary data to determine LULCC for a period of 50 years (1967-2016). The LULCC types identified were quantitatively evaluated using the change detection approach from results of maximum likelihood classification algorithm in GIS. Accuracy assessment results were evaluated and found to be between 56 to 98 percent of the LULC classification. The change detection analysis revealed change in the LULC types in Minna from 1976 to 2016. Built-up area increases from 74.82ha in 1976 to 116.58ha in 2016. 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Abstract Valdimarsson, H., Astthorsson, O. S., and Palsson, J. 2012. Hydrographic variability in Icelandic waters during recent decades and related changes in distribution of some fish species. – ICES Journal of Marine Science, 69: 816–825. Seasonal time-series of temperature and salinity around Iceland have been collected, with repeat observations at stations, since the start of the 1970s. After fairly cold years during the early 1990s, a reversal occurred during the mid-1990s and the period from 1996 to 2010 was one with warmer, more saline water in shelf seas around Iceland. Temperatures and salinities have been frequently above the long-term mean in the waters to the south and west of the country, and these conditions have also influenced the shelf area north of the country. Marked changes have also been observed in the distribution of many fish species during this warm period. Southern commercial species have extended farther north (e.g. haddock, monkfish, mackerel), a northern species is retreating (capelin), rare species and vagrants have been observed more frequently (e.g. greater fork beard, blue antimora, snake pipefish, sea lamprey, Ray's bream), and 31 species, from both shelf and oceanic waters, have been recorded for the first time since 1996. The most obvious explanation for these changes in the ecosystem has to be the warming of 1–2°C in the waters south and west of Iceland during the past 15 years.

During the past three decades, efforts have been made to reduce the risk of human exposure to pesticides specially insecticides. There is a great demand for safer and more selective insecticides that spare natural enemies and non target organisms. The present investigation was conducted during rabi season 2009 and 2010, to test the effectiveness of recently developed new ready mix insecticide Plethora (Novaluron 5.25 %+ Indoxacarb 4.5% SC) along with other insecticides against Helicoverpa armigera Hub and Spodoptera litura Fab. infesting tomato. It is observed that Plethora @ 875 ml/ha recorded only 3.75% fruit damage, while in control plot it was 45.6%. Though highest cost benefit ratio (1:6.17) was obtained when Plethora was applied at 825 ml/ha. Independently novaluron performed well specially against S. litura and indoxacarb showed better performance against H. armigera but lamda-cyhalothrin expressed comparatively lower performance than other selected insecticides which received 28.30% fruit infestation.

Carbon dioxide emission on peatland under oil palm plantation were highly varied probably due to many factors involved. The objectives of the research were to evaluate the effect of distance sampling from center of oil palm tree on Carbon dioxide flux, and to study the factors that cause variability of carbon dioxide flux on peatland under oil palm plantation. The study was conducted on peatland at Arang-Arang Village, Kumpek Ulu Sub-District, Muaro Jambi District, Jambi Province, on six year old oil palm plantation. The study was conducted in the form of observational exploratory. Emission measurements performed on 5 selected oil palm trees at points within 100, 150, 200, 250, 300, 350, and 400 cm from the center of trunk. Carbon dioxide flux was measured using (IRGA), Li-COR 820. The results showed that there is significant correlation between the distance of sampling from center of oil palm tree and Carbon dioxide flux. The farther distance from the tree, Carbon dioxide flux more decreased. Before applying fertilizer, variability of soil fertility was not significantly correlated with the flux of Carbon dioxide, so the difference of Carbon dioxide flux based on distance sampling can be caused by root distribution factor. After fertilizer application, variability of Carbon dioxide flux under the oil palm tree were beside affected by differences in root distribution, was also greatly influenced by fertilization.Keywords: Carbon dioxide flux, distance sampling, oil palm, peat, root-related respiration [How to Cite: Dariah A, F Agus, E Susanti and Jubaedah. 2013.Relationship between Sampling Distance and Carbon Dioxide Emission under Oil Palm Plantation. J Trop Soils 18 (2): 125-130. 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The association between immunity and metabolic syndrome (MetS) has been studied, but its interaction with lifestyles remains unclear. We studied their association and interactions with lifestyles in 40,768 adults aged over 40 years from a large-scale, hospital-based cohort study collected during 2010–2013. White blood cell counts (WBC) and serum C-reactive protein concentrations (CRP) were used as indexes of immune status. The participants were categorized into four groups by the cutoff points of 6.2 × 109/L WBC(L-WBC) and <0.5 mg/dL CRP(L-CRP): L-WBC+L-CRP(n = 25,604), H-WBC+L-CRP(n = 13,880), L-WBC+H-CRP(n = 464), and H-WBC+H-CRP(n = 820). The participants in the H-WBC+L-CRP were younger and had higher numbers of males than the L-WBC+L-CRP. MetS risk was higher by 1.75- and 1.86-fold in the H-WBC+L-CRP and H-WBC+H-CRP, respectively, than the L-WBC+L-CRP. MetS components, including plasma glucose and triglyceride concentrations, and SBP were elevated in H-WBC+L-CRP and H-WBC+H-CRP compared with L-WBC+L-CR+P. The risk of hyperglycemia and high HbA1c was the highest in the H-WBC+H-CRP among all groups. Areas of WBC counts and serum CRP concentrations were 0.637 and 0.672, respectively, in the receiver operating characteristic curve. Daily intake of energy, carbohydrate, protein, and fat was not significantly different in the groups based on WBC counts and CRP. However, a plant-based diet (PBD), physical activity, and non-smoking were related to lowering WBC counts and CRP, but a Western-style diet was linked to elevating CRP. A high PBD intake and smoking status interacted with immunity to influence MetS risk: a low PBD and current smoking were associated with a higher MetS risk in the H-WBC+H-CRP. In conclusion, overactivated immunity determined by CRP and WBC was associated with MetS risk. Behavior modification with PBD and physical activity might be related to immunity regulation.

Artikel review ini mengulas tentang prinsip dan proses metabolisme karbohidrat, lipid, protein dan asam nukeat pada organisme. Telaah pustaka yang disajikan dalam review ini bersumber pada jurnal ilmiah maupun buku terakreditasi yang relevan. Lintasan metabolisme karbohidrat, lipid, protein, asam nukleat terdiri atas tiga bentuk lintasan yakni katabolik, anabolik dan amfibolik. Lintasan tersebut umumnya terjadi pada mitokondria melalui siklus Krebs. Katabolisme protein, karbohidrat dan lemak dapat menjadi derivat asam amino, glukosa, gliserol dan asam lemak yang mampu dikonversi menjadi energi maupun cadangan energi untuk proses pertumbuhan dan perkembangan sel. Demikian sebaliknya proses anabolisme dapat memanfaatkan derivat makro molekul (asam amino, glukosa, fruktosa, asam lemak) menjadi makro molekul (protein, karbohidrat dan lipid). Proses metabolisme karbohidrat secara khusus melalui glikolisis, glikogenesis dan glukoneogenesis. Sedangkan metabolisme lemak melalui proses asetil-KoA terkarboksilase dan menghasilkan malonil-KoA hingga berlanjut pada proses pembentukan asam lemak melalui proses enzimatis (elongase dan desaturase). Demikian pula pada metabolisme protein yang diawali dengan pemecahan makro molekul dalam bentuk peptida menjadi monomer terkecil (asam amino) secara enzimatis (melibatkan enzim protease) dan menjadi salah satu sumber energi dalam pembentukan ATP untuk perkembangan sel. Sebaliknya anabolisme protein tersebut didasari oleh proses transmisi dan aminasi. Metabolisme asam nukleat melibatkan proses sintesis purin dan pirimidin sebagai nukleotida secara de novo. Proses metabolisme asam nukleat melaui proses enzimatik (housekeeping) yang sangat bertanggungjawab terhadap fungsi katabolisme dan anabolisme. Referensi: [1] Wali, J. A., Milner, A. J., Luk, A. W., Pulpitel, T. J., Dodgson, T., Facey, H. J., ... & Simpson, S. J. (2021). 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AbstractThe paper presents analysis of efficiency of the logging unit comprising Belarus 820 farm tractor and PD80 logging trailer equipped with Ryś-1 crane. Analysis was made based on the working day timing. The unit logged 1- meter long tree pieces (hornbeam, oak, birch) from the area where material for logging was distributed irregularly on the entire felling site. Unfavourable atmospheric conditions were reported during the working day (a thick layer of snow, low temperature, not frozen soil) which could have influenced the unit operation performance. Despite that the performance of the logging unit was comparable to similar logging units described in the literature. Determined coefficient of use of the operating time of the machine K02 was 0.93, coefficient of use of the shift working time K04 − 0.9, coefficient of use of the shift exploitation time K07 − 0.8. Hourly performance in the shift exploitation time was 4.98 m3·h−1, efficiency in the shift working time W02 − 4.80 m3·h−1 and performance in the general shift time W07 − 4.30 m3·h−1.

Paullinia cupanais used in weight-loss programs as a constituent of medicinal/dietary supplements. This study aimed to assess a potential herb-drug interaction among a standardized (certified)Paullinia cupanaextract and amiodarone (narrow therapeutic index drug) in rats. In a first pharmacokinetic study rats were simultaneously coadministered with a single dose ofPaullinia cupana(821 mg/kg, p.o.) and amiodarone (50 mg/kg, p.o.), and in a second study rats were pretreated during 14 days withPaullinia cupana(821 mg/kg/day, p.o.) receiving amiodarone (50 mg/kg, p.o.) on the 15th day. Rats of the control groups received the corresponding volume of vehicle. Blood samples were collected at several time points after amiodarone dosing, and several tissues were harvested at the end of the experiments (24 h after dose). Plasma and tissue concentrations of amiodarone and its major metabolite (mono-N-desethylamiodarone) were measured and analysed. A significant reduction in the peak plasma concentration (73.2%) and in the extent of systemic exposure (57.8%) to amiodarone was found in rats simultaneously treated withPaullinia cupanaand amiodarone; a decrease in tissue concentrations was also observed. This paper reports for the first time an herb-drug interaction betweenPaullinia cupanaextract and amiodarone, which determined a great decrease on amiodarone bioavailability in rats.

ABSTRACT The objective of the present study was to characterize the spatial and temporal (2000-2015) rainfall pattern variability and erosive potential in the different physiographic regions of the state of Pernambuco, Brazil. Rainfall data series (3 to 12 years) from 25 weather stations of the state were analyzed. Erosive rainfall events (more than 10 mm depth) were considered to evaluate the annual erosivity index, monthly erosivity index (EI30), rainfall erosivity factor (R), and rainfall pattern. The inverse distance weighting (IDW) - inverse of the square of the distance - was used to create spatial interpolation and develop maps. The rainfall data from the weather stations showed average annual rainfall of 827 mm and average erosivity of 4,784 MJ mm ha-1 h-1. The Metropolitan region of Pernambuco presented the highest rainfall erosivity index, with annual average of 9,704 MJ mm ha-1 h-1; and the Sertão do São Francisco region had the lowest, with annual average of 4,902 MJ mm ha-1 h-1. The state of Pernambuco presented advanced (42%), intermediate (38%), and delayed (20%) rainfall patterns.

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N-type Ca2+ channels (CaV2.2) are a nidus for neurotransmitter release and nociceptive transmission. However, the use of CaV2.2 blockers in pain therapeutics is limited by side effects resulting from inhibition of the physiological functions of CaV2.2 within the CNS. We identified an anti-nociceptive peptide (Brittain, J. M., Duarte, D. B., Wilson, S. M., Zhu, W., Ballard, C., Johnson, P. L., Liu, N., Xiong, W., Ripsch, M. S., Wang, Y., Fehrenbacher, J. C., Fitz, S. D., Khanna, M., Park, C. K., Schmutzler, B. S., Cheon, B. M., Due, M. R., Brustovetsky, T., Ashpole, N. M., Hudmon, A., Meroueh, S. O., Hingtgen, C. M., Brustovetsky, N., Ji, R. R., Hurley, J. H., Jin, X., Shekhar, A., Xu, X. M., Oxford, G. S., Vasko, M. R., White, F. A., and Khanna, R. (2011) Suppression of inflammatory and neuropathic pain by uncoupling CRMP2 from the presynaptic Ca2+ channel complex. Nat. Med. 17, 822–829) derived from the axonal collapsin response mediator protein 2 (CRMP2), a protein known to bind and enhance CaV2.2 activity. Using a peptide tiling array, we identified novel peptides within the first intracellular loop (CaV2.2(388–402), “L1”) and the distal C terminus (CaV1.2(2014–2028) “Ct-dis”) that bound CRMP2. Microscale thermophoresis demonstrated micromolar and nanomolar binding affinities between recombinant CRMP2 and synthetic L1 and Ct-dis peptides, respectively. Co-immunoprecipitation experiments showed that CRMP2 association with CaV2.2 was inhibited by L1 and Ct-dis peptides. L1 and Ct-dis, rendered cell-penetrant by fusion with the protein transduction domain of the human immunodeficiency virus TAT protein, were tested in in vitro and in vivo experiments. Depolarization-induced calcium influx in dorsal root ganglion (DRG) neurons was inhibited by both peptides. Ct-dis, but not L1, peptide inhibited depolarization-stimulated release of the neuropeptide transmitter calcitonin gene-related peptide in mouse DRG neurons. Similar results were obtained in DRGs from mice with a heterozygous mutation of Nf1 linked to neurofibromatosis type 1. Ct-dis peptide, administered intraperitoneally, exhibited antinociception in a zalcitabine (2′-3′-dideoxycytidine) model of AIDS therapy-induced and tibial nerve injury-related peripheral neuropathy. This study suggests that CaV peptides, by perturbing interactions with the neuromodulator CRMP2, contribute to suppression of neuronal hypersensitivity and nociception.

BackgroundFamilial Mediterranean fever (FMF) is a rare hereditary autoinflammatory disease with disease onset in childhood in most cases. Although autoinflammatory disease awareness is increasing among physicians, delayed diagnosis is still prevalent as a cause of greater morbidity[1].ObjectivesWe aimed to study the characteristics of FMF patients diagnosed between 2000-2010 and 2011-2021 and to see if there was a difference in diagnostic delay.MethodsWe retrospectively evaluated the medical records of the FMF patients followed up in our rheumatology clinic that were diagnosed between 2000-2021 and split them into two groups according to the year they received their diagnosis. There were 1151 patients diagnosed between 2000-2010 (Group 1) and 821 patients diagnosed between 2011-2021 (Group 2). The data studied included gender, age of onset, diagnostic delay, attack characteristics, MEFV mutation, and family history.ResultsThe median current age of patients in Group 1 is 37 years (IQR:30-46) and the median current age of the patients in Group 2 is 36 years (IQR:29-44). The female to male ratio was 1.57 in Group 1 and 1.75 in Group 2, with no significant difference between the groups. Group 2 had later disease onset (p<0.001) and later diagnosis (p<0.001) than Group 1 as shown in the Table 1. The proportion of patients with at least one M694V mutation was higher in Group 2 (p<0.001). The attack durations did not vary between the groups. There was no significant difference in the prevalence of abdominal pain, fever, arthritis, and arthralgia between Group 1 and Group 2. Chest pain (p=0.005), myalgia (p<0.001), and erysipelas-like erythema (p=0.041) were more common in Group 2 than Group 1. Patients with positive family history were more frequent in Group 2 than Group 1 (p=0.046).Table 1.Group 1 (2000-2010, n=1151)Group 2 (2011-2021, n=821)pFemale/Male, n704/447522/2990.275Age at onset, median (IQR) years13 (7-21)18 (12-26)<0.001Delay in diagnosis, median (IQR) years4 (1-11)5,5(2-15)<0.001Attack duration, median (IQR) years3(2-4)3(2-4)0.325Presence of at least one M694V mutation (%)526(46%)390(60%)<0.001Presence of abdominal pain in the initial attack (%)936(81%)669(81%)0.926Presence of fever in the initial attack (%)855(74%)592(72%)0.281Presence of chest pain in the initial attack (%)218(19%)199(24%)0.005Presence of arthritis in the initial attack (%)330(29%)215(26%)0.224Presence of arthralgia in the initial attack (%)213(19%)170(21%)0.223Presence of myalgia in the initial attack (%)45(4%)65(8%)<0.001Presence of erysipelas like erythema in the initial attack (%)31(3%)36(4%)0.041Presence of positive family history (%)652(57%)502(61%)0.046ConclusionThere was some increase in the diagnostic delay in 2011-2021 compared to 2000-2010. This may be partly due to the later onset of symptoms in patients diagnosed in 2011-2021, which could have led the physicians to consider other differential diagnoses. Nevertheless, diagnostic delay in FMF still seems a prevalent problem that should be addressed to prevent excess morbidity and mortality.References[1]Erdogan M, Ugurlu S, Ozdogan H, Seyahi E. Familial Mediterranean fever: misdiagnosis and diagnostic delay in Turkey. Clin Exp Rheumatol. 2019;37 Suppl 121(6):119-124.Disclosure of InterestsNone declared