Статті в журналах: "2003 n-782"

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Cobo Sánchez, José Luis, Antonio Ochando-García, Ian Blanco Mavillard, Francisco Cirera Segura, Rodolfo Crespo Montero, and Rafael Casas Cuestas. "Análisis del impacto de la producción científica de la revista Enfermería Nefrológica entre 1998 y 2017." Enfermería Nefrológica 21, no. 4 (December 12, 2018): 349–58. http://dx.doi.org/10.4321/s2254-28842018000400004.

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Introducción: Enfermería Nefrológica es la publicación oficial de la Sociedad Española de Enfermería Nefrológica, que cumple su 20 aniversario. El análisis de los artículos de una revista permite determinar la evolución de una publicación. Objetivo: Analizar la producción científica publicada en la revista Enfermería Nefrológica durante el periodo 1998-2017. Metodología: Estudio bibliométrico descriptivo transversal de la revista Enfermería Nefrológica, del volumen 1 al 20, mediante el software “Publish or Perish” V6. Se analizaron las siguientes variables: número total de artículos y de citas; citas por artículo, por autor, por año; artículos por autor y autores por artículo; AWCR, índice g e índice h. Se realizaron análisis por periodos de 5 años (P1 1998-2002, P2 2003-2007, P3 2008-2011, P4 2012-2017). Resultados: Se analizaron 1198 artículos: P1 n=81 (6,76%), P2 n= 160 (13,35%), P3 n=164 (13,68%), P4 n=793 (66,19%); y 2167 citaciones: P1 n=47 (2,17%), P2 n= 759 (35%), P3 n=782 (36%), P4 n=579 (26,7%). Media de autores por artículo: P1: 1,96, P2: 2,66, P3: 2,82, P4: 3. AWCR: P1: 2.80 (sqrt=1.67) 1.58/autor, P2: 60.33 (sqrt=7.77) 26.58/autor, P3: 93.93 (sqrt=9.69), 35.21/autor, P4: 147.12 (sqrt=12.13), 57.31/autor. Índice h: P1: 4 (a=2.94, m=0.20, 35 citas=74.5% cobertura), P2: 16 (a=2.96, m=1.07, 433 citas=57.0% cobertura), P3: 9 (a=7.15, m=1.50, 116 citas=20.0% cobertura), P4: 11 (g/h=1.22, 133 citas=23.0% cobertura). Conclusiones: La revista Enfermería Nefrológica ha crecido de forma exponencial en los últimos 20 años, tanto en volumen de producción como en calidad y visibilidad, convirtiéndose en la publicación de referencia del cuidado renal en el ámbito hispano-hablante.

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Borisov, I. M., and T. G. Shapovalova. "Prediction of community-acquired pneumonia complications in military men." Kazan medical journal 93, no. 6 (December 15, 2012): 864–70. http://dx.doi.org/10.17816/kmj2093.

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Aim. To develop diagnostic algorithm to predict the risk of community-acquired pneumonia development. Methods. 2000 patients with community-acquired pneumonia (male conscripts aged 18 to 22 years, mean age 19.2±0.19). A comparative analysis of two groups of patients to assess the algorithm for toxic shock syndrome, acute respiratory failure and acute kidney injury prediction was performed. In the comparison group (n=782, 1998 to 2003), prediction of complications was based on doctors’ personal knowledge and experience without using the prediction algorithms. In the main group (n=1218, 2003 to 2008), the established prediction algorithm was used. Results. The introduction of community-acquired pneumonia complications prediction algorithm allowed to decrease the incidence of such complications significantly. Toxic shock syndrome was diagnosed in 8.8% of patients in the comparison group and in 3.7% of patients of the main group (р 0.05), acute respiratory failure - in 43.1% of patients of the comparison group and in 19.5% of patients of the main group (р 0.05). The effectiveness of the algorithm for toxic shock syndrome prognosis was 90.8%, sensitivity - 91.8%, specificity - 89.7%, accuracy - 94.5%. The effectiveness of the algorithm for acute kidney injury prognosis was 90.7%, sensitivity - 90.7%, specificity - 90.8%, accuracy - 95.1%. Conclusion. Offered prediction algorithms can help a physician to suspect a possibility of potentially dangerous and lethal complications development in patients with community-acquired pneumonia at the early stages of the disease. It allows to adjust the treatment, to simplify the estimate for transportation need, to detect the indications for patients admission, including the admission to intensive care unit, and improve the results of treatment.

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Al-Ani, Fatimah, Yo-Liang Teng, Alla Iansavichene, and Alejandro Lazo-Langner. "Evaluating the Effect of Ethnicity on the Risk of Venous Thromboembolism (VTE): A Systematic Review." Blood 126, no. 23 (December 3, 2015): 4714. http://dx.doi.org/10.1182/blood.v126.23.4714.4714.

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Abstract Background Studies of hospital discharge data and large observational cohorts show that the incidence of venous thromboembolism (VTE) varies by race. We sought to determine the incidence of VTE in each of the following ethnic groups Caucasians, Africans, Asians, and Hispanics. Methods A systematic literature search strategy was used to identify potential studies in MEDLINE, EMBASE, and CENTRAL using an OVID interface. The methodological quality of eligible studies was assessed according to Newcastle-Ottawa Quality Assessment Scale. The primary outcome measure was to identify the incidence/prevalence of VTE of each ethnic group available for the study in the context of a population based study. Results Out of 3418 potential studies, 19 met our inclusion criteria (Table). Of these, 9 studies were population based studies: 5 reported VTE incidence per 100,000 person-years (PY), 2 measured the standardized incidence ratio, and 2 European studies assessed VTE rate according to country of origin but not ethnicity (data not shown). In addition, 7 studies measured the hospital incidence rate of VTE, and 3 assessed VTE prevalence. Data could not be pooled due to marked heterogeneity including varied periods of study. VTE incidence per 100,000 PY was found to be between 162 and 439 in Caucasians, 143 and 746 in Africans, 3.2 and 16.6 in Asians. Hospital incidence of VTE per 100,000 PY was found to be between 21 and 131 in Caucasians, 22 and 155 in Africans, 2 and 26 in Asians, 33.1 and 71 in American Indians/Alaskan Indians, and 9 in Hispanics. Conclusions Our findings suggest a wide variation in reported incidence rates for VTE among different ethnic groups, even within the same group. In general, studies in Asian populations suggest a lower incidence of VTE. A marked heterogeneity of study designs, population settings prevent drawing firm conclusions. A significant risk of bias cannot be excluded for several studies. Further studies assessing concurrently the risk of VTE among different ethnicities in the same geographical area are needed. Table 1. Summary of the included studies. Study Country Time Period f/u duration Sample size VTE incidence /Prevalence (95% CI) Zakai, 2014 US 439,090 person year 51,149 Zakai: ARIC US 1987-1996 15,792 (I) Cauc.: 166 (1.48-1.86) Afr.: 259 (2.21-3.03) Zakai: CHS US 1989-1997 5,888 (I) Cauc.: 439 (3.13-6.16) Afr.: 746 (4.68-11.90) Zakai: REGARDS, Southeast area US 2003-2007 30,239 (I) Cauc.: 162 (1.26-2.07) Afr.: 224 (1.72-2.92) Zakai: REGARDS, Rest of US US 2003-2007 30,239 (I) Cauc.: 205 (1.58-2.66) Afr.: 143 (1.02-2.00) Deitelzweig, 2010 US 2002 46,652 (P) per 100,000 persons Cauc.: M 457, F NA Afr.: M 584, F NA Hisp.: M 94, F 93 Others: M 329, F 345 2005 46,652 (P) per 100,000 persons Cauc.: M 643, F 446 Afr.: M 784, F 444 Hisp.: M 149, F 154 Others: M 285, F 297 DeMonaco, 2008 US 1997 37,892 (HI) Cauc.: 44 Afr.: 53 2001 37,892 (HI) Cauc.: 56 Afr.: 60 Heit, 2010 US 2003-2009 2,397 (P) N(%) Cauc.: Total= 1381 (69) Afr.: Total=272 (69) N(%) Cauc.: VTE = 551 (27) Afr.: VTE = 75 (19) Hooper, 2003 US 1980-1996 (HI) American Indians/Alaskan Indians: 33.1 Jang, 2011 Korea 2004 (I) Asians: VTE: 8.83, DVT: 3.91, PE: 3.74 2008 (I) Asians: VTE: 13.8, DVT: 5.31 , PE: 7.01 Kitamukai, 2003 Japan 2000 (I) Asians: 3.2 (29.2-33.9) Klatsky, 2000 US 1978-1994 1,822,302 total person years 128,934 (HI) Cauc.: 21 Afr.: 22 Asians: 2 Hisp.: 9 Others (unspecified): 15 Lee, 2010 Taiwan 2001 & 2002 11,566 person year Crude Incidence per 100,000 person year: Asians: VTE=15.9 Liu, 2002 China 1997-2000 (I) Asians: 16.6 Sakuma, 2009 Japan 2006 (I) Asians: PE= 6.19 (51.7- 72.1) DVT= 11.5 (98.2-132.9) Schneider, 2006 US 1998-2000 (HI) Cauc.: M 36.47 ; F 37.96 Afr.: M 53.64 ; F 61.53 Stein, Am J Med. 2004 US 1990-1999 (HI) Cauc.: VTE= 122 Afr.: VTE= 134 Asians: VTE= 23 Stein, Arch Intern Med. 2004 US 1996-2001 (HI) Cauc.: 131 Afr.: 155 American Indians and Alaskan Indians: 71 Tan, 2007 Singa-pore 1998-2001 271 pairs of cases and controls (P) N(%) Asians: 32.1% (29.0-35.3) White, 2005 US 1996 21,002 (SIR): Cauc.: 103 (101-105) Afr.: 138 (132-145) Asians: 29 (27-32) Hisp.: 61 (59-64) Others: 72 (65-80) White, 1998 US 1991-1994 17991 (SIR): Cauc.: 23 Afr.: 29.3 Asians: 6 Hisp.: 13.9 Abbreviations. f/u: follow up; CI: confidence interval; (I): incidence per 100,000 PY; (P): prevalence; (HI): Hospital Incidence per 100,000 PY; (SIR): Standardized Incidence Rate; M:male; F: female; N: total number. Cauc. Caucasians, Afr. Africans, Hisp. hispanics Disclosures Lazo-Langner: Pfizer: Honoraria; Bayer: Honoraria.

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Braun, Lois, Jeffrey Gillman, Emily Hoover, and Michael Russelle. "Nitrogen fertilization for new plantings of hybrid hazelnuts in the Upper Midwest of the United States of America." Canadian Journal of Plant Science 91, no. 4 (July 2011): 773–82. http://dx.doi.org/10.4141/cjps2011-015.

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Braun, L. C., Gillman, J. H., Hoover, E. E. and Russelle, M. P. 2011. Nitrogen fertilization for new plantings of hybrid hazelnuts in the Upper Midwest of the United States of America. Can. J. Plant Sci. 91: 773–782. Seed-propagated hybrids of Corylus avellana and C. americana are a potential crop for the Upper Midwest. Current N recommendations for hazelnuts are based on research on clonally propagated C. avellana in Oregon and may not be applicable in the Upper Midwest due to differing soils, climate, and plant genetics. We established three field plots in 2003 to test N fertilization rates on new plantings, with rates up to 33 g N plant−1 as ammonium nitrate applied annually in the spring, starting 2 wk after transplanting. We observed a strong negative linear effect of N rate on plant survival. In the second year we added trials on same-aged plants that had not previously been fertilized and found no N effect on survival. We concluded that waiting 1 yr after transplanting before fertilizing increases plant survival, but even then N requirements during establishment years are very low for hybrid hazelnuts. Standard leaf N concentrations for C. avellana in Oregon are roughly applicable to hybrid hazelnuts, except that the threshold between deficiency and sufficiency should be raised slightly to 1.9% N. The current threshold between deficient and sufficient, 2.2%, should be regarded as a target, rather than as a threshold to be exceeded.

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Bruno, Benedicte, David Seguy, Vincent Maunoury, Valerie Coiteux, Leonardo Magro, Francis Bauters, Francoise Mazingue, Jean-Pierre Jouet, and Ibrahim Yakoub-Agha. "Improvement of Supportive Care in Patients Undergoing Myeloablative Allogeneic Stem Cell Transplantation Not Only Reduces Transplant-Related Mortality but Also Increases Long-Term Survival." Blood 112, no. 11 (November 16, 2008): 4318. http://dx.doi.org/10.1182/blood.v112.11.4318.4318.

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Abstract One of major hurdles to achieving good patient outcomes and survival rates in allogeneic stem cell transplantation (allo-SCT) after myeloablative conditioning is the high rate of transplant-related mortality (TRM). Much progress in supportive patient care has been accomplished over the last decade-notably the use of allelic HLA-matching (Yakoub-Agha, JCO 2006), the introduction of enteral nutrition (Seguy, Transplantation 2004), the development of wireless video-capsule endoscopy for the management of post-transplant diarrhea (Yakoub-Agha, Transplantation 2005), the availability of broad-spectrum antifungal prophylaxis, the use of busulfan IV instead of PO in the conditioning regimen, limitation of the use of ATG in graft-versus-host disease (GVHD) treatment and dose reduction when the latter drug is used in conditioning. Although all these various modifications have had a positive impact on short-term patient outcomes, their impact on long-term survival is still unclear. Hence, the main objective of the present study was to evaluate allo-CST outcomes as a function of the transplantation period. A total 445 patients have undergone post-myeloablation allo-CST in our department. The patient distribution over the time was as follows: prior to 1998 (first period): n=133; between 1998 and 2003 (second period): n=154; between 2003 and 2007 (third period): n=158. Only the first transplant for a given individual was taken into account. Kaplan-Meyer curves were plotted for 100-day survival, 180-day survival and 3-year survival for each time period. Setting aside the clear differences in supportive care methods, the three groups were well matched in terms of disease diagnosis, disease status at transplant and the main recipient and donor characteristics. It is noteworthy, however, that the median age of patients increased over time. Mean 100-day survival was 86 days (95% CI: 81–90), 93 days (95% CI: 90–96) and 96 days (95% CI: 94–98) for the first, second and third periods, respectively (p<.0001). Mean 180-day survival was 137 days (95% CI: 126–147), 157 days (95% CI: 150–164) and 165 days (95% CI: 160–171) for the first, second and third periods, respectively (p<.0001). The improvement in short-term survival has translated into an improvement in long-term survival, as the mean 3-year survival was 513 days (95% CI: 437–591), 705 days (95% CI: 635–775) and 782 days (95% CI: 715–850) for the first, second and third periods, respectively (p<0.0001). Median survival was 339 days (95% CI: 145–533) for the first period but has not yet been reached for the two other periods. While we observed a significant reduction in TRM over the three periods, post-transplantation relapse is still a major complication which impacts negatively on long-term patient outcomes. In conclusion, this study highlights the positive impact of supportive care on both short-term patient outcomes and long-term survival after myeloablative allo-CST. The most recent data on myeloablative allo-CST must be taken into account before ruling out the latter as treatment option. Although supportive care will doubtless continue to progress, further research into reducing the post-transplantation relapse rate must now become a priority.

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Loeppenberg, Bjoern, Christian von Bodman, Marko Brock, Joachim Noldus, and Jueri Palisaar. "Impact of functional outcomes on long-term quality of life after open retropubic radical prostectomy." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 9580. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.9580.

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9580 Background: Patients who underwent open retropubic radical prostatectomy (ORRP) for prostate-cancer (PCA) have excellent long-term survival. Besides oncologic safety, recovery of continence and erectile function are highly important, as adverse functional outcomes may have a detrimental effect on health-related quality of life (HRQOL). We report the long-term HRQOL of PCA survivors after ORRP using standardized tools. Methods: Men treated between August 2003 and December 2007 with ORRP for localized PCA at a single academic hospital received validated questionnaires (International consultation on incontinence questionnaire (ICIQ), International index of erectile function (IIEF-5), Erection hardness score (EHS), EORTC QLQ-C30) to assess functional outcomes and HRQOL. Results were correlated with the global-health score (GHS) of the EORTC QLQ-C30 to assess the impact of ORRP on HRQOL. Results: In the study period 1936 men underwent ORRP of whom 1156 (59.7%) received a nerve-sparing (NS) procedure. Questionnaire return-rate was 59% (n=1141) comprising the final study cohort. Median follow-up (FU) was 62 months. Mean age at surgery and FU was 63.7±6.2 and 69.2±6.2 years, respectively. Biochemical recurrence (BCR) occurred in 17.5% (n=200/1141) and 2% (n=40/1936) deceased. Mean GHS in the study population was 71.5±20.8. In the ICIQ 28% (n=320) scored 0 indicating complete continence and 9.9% (n=113) scored ≥11 indicating severe incontinence. The corresponding GHS was 78.1±19.5 and 55.4±21.8, respectively. 68.5% (n=782) of patients used no pads and 17.9% (n=204) ≥2 pads. Corresponding GHS scores were 74.9±19.8 and 58.9±20.7. Using the IIEF-5 in men who received NS, 24.1% (n=154) had no erectile dysfunction versus 50% (n=318) using the EHS. Corresponding GHS scores were 82.2±16.3 and 74.7±19.8, respectively. Patients with BCR had a GHS of 66.8±21.8 versus 72.5±20.5 for patients without. Men who achieved the Trifecta and Pentafecta criteria had a GHS of 83.1±15.1 and 83.3±15, respectively. Conclusions: Incontinence severely impacts the HRQOL of long-term survivors after ORRP while erectile dysfunction and BCR have a lesser effect. Every effort should be undertaken to maintain functional integrity.

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Desplenter, Franciska, Piia Lavikainen, Sirpa Hartikainen, Raimo Sulkava, and J. Simon Bell. "Sedative use and incident cognitive decline among persons aged 75 years and older: a population-based longitudinal study." International Psychogeriatrics 24, no. 1 (August 16, 2011): 48–54. http://dx.doi.org/10.1017/s1041610211001359.

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ABSTRACTBackground: Acute exposure to sedative drugs may induce memory impairment, but there is mixed evidence that long-term sedative use may result in incident cognitive decline. The objective of this study was to investigate the use of sedative drugs and incident cognitive decline in a population-based sample of persons aged 75 years and older.Methods: The study sample comprised 781 participants in the Geriatric Multidisciplinary Strategy for the Good Care of the Elderly (GeMS) study in Kuopio, Finland. Data on health status, drug use, and sociodemographic factors were elicited during annual nurse interviews from 2004 to 2007. A linear mixed model was used to compare change in Mini-Mental State Examination (MMSE) scores (2005–2007) among users of sedative drugs in 2004 and 2005 (n = 139) to non-users of sedative drugs from 2004 to 2007 (n = 310). The model was adjusted for covariates including age, gender, education, depressive symptoms and antipsychotic use.Results: Unadjusted mean MMSE scores were 27.50 in 2005, 26.58 in 2006, and 25.95 in 2007 among users of sedative drugs. Unadjusted mean MMSE scores were 28.05 in 2005, 27.61 in 2006, and 27.09 in 2007 among non-users of sedative drugs. Adjusted mean MMSE scores were 0.31 points lower in 2005, 0.62 points lower in 2006, and 0.93 lower in 2007 among users compared to non-users of sedative drugs (P = 0.051).Conclusions: Sedatives were not associated with statistically significant cognitive decline. However, clinicians should maintain a judicious approach to prescribing sedative drugs given the risk of adverse drug events.

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Готцева, Маріана. "A Neurocognitive Perspective on Language Acquisition in Ullman’s DP Model." East European Journal of Psycholinguistics 4, no. 2 (December 28, 2017): 24–33. http://dx.doi.org/10.29038/eejpl.2017.4.2.got.

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In the last few decades, the studies in second language acquisition have not answered the question what mechanisms a human’s brain uses to make acquisition of language(s) possible. A neurocognitive model which tries to address SLA from such a perspective was suggested by Ullman (2005; 2015), according to which, “both first and second languages are acquired and processed by well-studied brain systems that are known to subserve particular nonlanguage functions” (Ullman, 2005: 141). The brain systems in question have analogous roles in their language and nonlanguage functions. This article is meant to critically analyse the suggested DP model within the context of neurocognitive studies of L2; and evaluate its contribution to the field of SLA studies. References Aboitiz, F. (1995). Working memory networks and the origin of language areas in the human brain. Medical Hypothesis, 25, 504-506. Aboitiz, F. & Garcia, R. (1977). The anatomy of language revisited. 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Impairments in verb morphology after brain injury: a connectionist model. Proceedings of the National Academy of Science USA. 96, (7592 –7597). Middleton, F.A., Strick, P.L. (2000). Basal ganglia and cerebral loops: motor and cognitive circuits. Brain research reviews, 31, 236-250. Moro, A., Tettamanti, M., Perani, D., Donati, C., Cappa, S. F., & Fazio, F. (2003). Syntax and the brain: disentangling grammar by selective anomalies. Neuroimage, 13(1), 110–118. Neurolinguistic and Psycholinguistic Perspectives on SLA. (2010). Arabski, J. & Wojtaszek, A. (Eds.), Bristol: Multilingual Matters. Newport, E. (1993). Maturational constraints on language learning. Cognitive Science, 14(1), 11-28. Opitz, B. & Friederichi, A.D. (2003). Interactions of the hippocampal system and the prefrontal cortex in learning language-like rules. Neuroimage, 19(4), 1730-1737. Packard, M.& Knowlton, B. (2002). Learning and memory functions of the basal ganglia. Annual Review of Neuroscience, 25, 563–593. Park, D., Lautenschlager, G., Hedden, T., Davidson, N., Smith, A. & Smith, P. (2002). Models of visuospatial and verbal memory across the adult life span. Psychology and Aging, 16, 299-320. Peelle, J.E., McMillan, C., Moore, P., Grossman, M. & Wingfield, A. (2004). Dissociable patterns of brain activity during comprehension of rapid and syntactically complex speech: evidence from fMRI. Brain and Language, 91, 315-325. Pinker, S. (1994). The Language Instinct. New York: William Morrow. Poldrack, R., Packard, M. G. (2003). Competition among multiple memory systems: converging evidence from animal and human brain studies. Neuropsychologia, 41(3), 245–251. Roediger, H.L., Butler, A.C. (2011). The critical role of retrieval practice in long-term retention. Trends in Cognitive Science, 15, 20-27. Schlaug, G. (2001). The brain of musicians: a model for functional and structural adaptation. Annals of the New York Academy of Sciences, 930(1), 281-299. Squire, L.R., Knowlton, B.J. (2000). The medial temporal lobe, the hippocampus, and the memory systems of the brain. In: The New Cognitive Neurosciences. (pp. 765-780). M. S. Gazzaniga, Ed. Cambridge, MA: MIT Press, Squire, L. R., Zola, S. M. (1996). Structure and function of declarative and nondeclarative memory systems. Proceedings of the National Academy of Sciences USA, 93. (13515–13522). Sun, R., Zhang, X. (2004). Top-down versus bottom-up learning in cognitive skill acquisition. Cognitive Systems Research, 5, 63–89. Ullman, M.T. (2004). Contributions of memory circuits to language: the declarative/procedural model. Cognition, 92(1-2), 231-70. Ullman, M.T. (2005). A cognitive neuroscience perspective on second language acquisition: the declarative/procedural model. In: Adult Second Language Acquisition, (pp. 141-178). C. Sanz, (ed.). Washington, DC: Georgetown University Press. Ullman, M.T. & Pieport, E.I. (2005). Specific language impairment is not specific to language: the procedural deficit hypothesis. Cortex, 41, 399-433. Ullman, M. (2006). Is Broca’s area part of a basal ganglia thalamocortical circuit? In: The Cortex: Integrative Models of Broca’s Area and the Ventral Premotor Cortex. (pp. 480-485). R. Schubotz & C. Fiebach, (Eds.). Milan: Masson. Ullman, M. (2015) The declarative / procedural model: A neurobiologically motivated theory of first and second language. In: Theories in Second Language Acquisition: An Introduction, (pp. 135-158.) VanPatten, B. and J. Williams, (Eds.). 2nd ed. New York: Routledge. Ullman, M. and Lovelett, J. (2016). Implications of the declarative / procedural model for improving second language learning: The role of memory enhancement techniques. Second Language Research, Special issue, 1-27. Zurowski, B., Gostomzyk, J., Gron, G., Weller, R., Schirrmeister, H., Neumeier, B., Spitzer, M., Reske, S.N. & Walter, H. (2002). Dissociating a common working memory network from different neural substrates of phonological and spatial stimulus processing. Neuroimage, 15, 45-57.

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9

Sarajlija, Nikola. "Fredholmness and Weylness of block operator matrices." Filomat 36, no. 8 (2022): 2507–18. http://dx.doi.org/10.2298/fil2208507s.

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This paper has aim to characterize Fredholmness and Weylness of upper triangular operator matrices having arbitrary dimension n ? 2. We present various characterization results in the setting of infinite dimensional Hilbert spaces, thus extending some known results from Cao X. et al. (Acta Math. Sin. (Engl. Ser.) 22 (2006), no. 1, 169-178 and J. Math. Anal. Appl. 304 (2005), no. 2, 759-771) and Zhang et al. (J. Math. Anal. Appl. 392 (2012), no. 2, 103-110) to the case of arbitrary dimension n ? 2. We pose our results without using separability assumption, thus improving perturbation results fromWu X. et al. (Ann. Funct. Anal. 11 (2020), no. 3, 780-798 and Acta Math. Sin. (Engl. Ser.) 36 (2020), no. 7, 783-796).

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10

Rosenberg, Aaron S., Ann M. Brunson, Theresa HM Keegan, Brian Jonas, Joseph Tuscano, and Ted Wun. "The Effect of Autologous Stem Cell Transplant (ASCT) on Survival in Californians with Multiple Myeloma (MM) in the Era of Modern Treatment." Blood 126, no. 23 (December 3, 2015): 1991. http://dx.doi.org/10.1182/blood.v126.23.1991.1991.

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Abstract Background: The use and timing of ASCT on survival after MM in the era of modern therapy remain topics of debate. Using population based data, we evaluated factors associated with the receipt of ASCT and the effect of ASCT on overall survival (OS). Methods: Patients diagnosed with MM during 2000 - 2012 were identified in the California Cancer Registry (CCR) (n=12,714). CCR data were linked to the California Patient Discharge Database (PDD). Logistic regression estimated the odds ratio (OR) of having an early (< 1 year from diagnosis) or late (> 1 year) ASCT (vs. no ASCT). OS was calculated using the Kaplan-Meier (KM) method. To determine the effect of ASCT on OS from diagnosis date, Cox regression models estimated adjusted hazard ratios (aHR) of death treating ASCT as a time dependent covariate. OS time was compared after matching ASCT to no ASCT patients on age, sex, race/ethnicity, neighborhood socioeconomic status (SES), comorbidity at diagnosis, year of diagnosis, and accounting for time to transplant. Results: The majority of MM patients were male (54%) and of non-Hispanic white (58%) race/ethnicity; 19% Hispanic, 12% African American, and 9% Asian. Median age at diagnosis was 67 (range 18 - 104). African Americans and Hispanics were younger than non-Hispanic whites (median age 64 and 65 vs 69). Comorbidity data from the PDD was available in 59% of the patients in the 2 years prior to MM diagnosis: 7.5% had 0, 21% had 1-2, and 31% had ≥3 comorbidities. A total of 2136 (17%) patients underwent ASCT: 1347 < 1 year from and 789 ≥1 year after diagnosis. Time to ASCT did not change over time: among patients diagnosed 2000 - 2003 median time to transplant was 9.2 mo, 10 mo among those diagnosed 2004 - 2007 and 9.7 in those diagnosed 2008 - 2012. Patients who underwent ASCT were younger than those who did not (median age 56 vs 70 respectively). African Americans were less likely to undergo early ASCT (OR 0.7, P<0.001), but not late ASCT (OR 0.8, P=0.07). Patients with ≥3 comorbidities (vs. 0) at diagnosis were less likely to have ASCT (OR 0.42 P<0.001 and OR 0.28 P<0.001 for early and late, respectively), while patients with 1-2 comorbidities were less likely to have late ASCT (OR 0.59 P<0.001). The lowest 2 quintiles of SES was associated with less use of early ASCT (OR 0.62 p<0.001 and 0.65 p<0.001 respectively), but not late ASCT (OR 0.89 p=0.4 and 0.96 p=0.7 respectively). The likelihood of receiving ASCT increased over time: compared to 2000-2003, the ORs for patients diagnosed in 2004 - 2007 were 1.36 for early (P<0.001) and 1.64 (P<0.001) for late ASCT and were 2.64 (P<0.001) for early and 1.80 (P<0.001) for late for those diagnosed in 2008-2012. The median follow-up was 32 months. Median OS from diagnosis for the entire cohort, unadjusted for age, comorbidities, and SES was 37 months. Adjusting for sex, race/ethnicity, age at diagnosis, SES, comorbidities, insurance status and year of diagnosis, OS improved over time: compared to patients diagnosed in 2008 - 2012, aHR of death of those diagnosed 2000-2003 was 1.58 (P<0.001), and 1.35 (P<0.001) for those diagnosed 2004-2007. ASCT at any point was associated with a 23% reduction in the risk of death from all causes (aHR 0.77 P<0.001). Patients who received early ASCT had a 27% reduction (aHR 0.73 P<0.001), while those receiving late ASCT had an 11% decrease (aHR 0.89 P<0.001) in risk of all cause death. In the matched analysis, the median OS from date of transplant, or matched date in the no ASCT cohort, were: no ASCT = 49 mo, early ASCT = 83 mo, and late ASCT 65 mo (P<0.001 Figure 1). The effect of aSCT on OS differed by date of diagnosis (P for interaction <0.001). Improvements in OS due to ASCT were more pronounced in later time periods: aHR for early and late ASCT in 2000-2003 were 0.9 (P = 0.12) and 0.98 (P 0.86) compared with those in 2004-2007 (0.63 P<0.001 and 0.85 P = 0.06) and in 2008-2012 (0.55 P<0.001 and 0.74 P=0.08). Conclusions :ASCT was utilized in 17% of Californians with MM during 2000-2012, and its use increased over time. The use of ASCT, whether within a year of diagnosis or later in the disease course, is associated with improved OS and this effect may be more pronounced in the era of novel agents. Despite the inherent limitations of analyses of administrative databases, the large number of patients and established robust nature of CCR and PDD data makes accurate depiction of results in the community probable. These data support the continued role of ASCT in the management of patients with MM. Disclosures Jonas: Celgene: Honoraria; Incyte: Honoraria; Onyx: Honoraria; GlycoMimetics: Consultancy.

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11

Benabed, Yasmine, Diana Dahliah, Mickael Dolle, and Geoffroy Hautier. "Exploring Charged Defects and Dopability Limits of Solid Electrolytes, a Computational Study." ECS Meeting Abstracts MA2022-01, no. 1 (July 7, 2022): 151. http://dx.doi.org/10.1149/ma2022-011151mtgabs.

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All-Solid-State Lithium Batteries (ASSLBs) are a new generation of lithium batteries that is developed to meet high expectations in terms of safety, stability and high energy density. The liquid electrolyte of conventional Li-ion batteries is replaced in ASSLBs by a safer and more stable solid electrolyte (SE). These solid electrolytes must meet a number of requirements before they can be considered in ASSLBs, including a wide electrochemical stability window, a high ionic conductivity and a negligible electronic conductivity [1]. For a long time, researchers have focused on achieving the highest ionic conductivity possible on these materials, comparable to the one of liquid electrolytes. The ionic conductivity in SEs has been successfully increased by the introduction of defects (doping) and Li1.3Al0.3Ti1.7(PO4)3 and Li1.5Al0.5Ge1.5(PO4)3 solid electrolytes are both excellent examples of such achievement. However, the formation of defects can also have a significant effect on the SEs electronic conductivity [2],[ 3],[ 4]. Increasing the electronic conductivity in solid electrolytes is detrimental to the ASSLBs safety and integrity. Therefore, it is essential to understand the defect chemistry in SEs. Due to their negligible concentration, characterizing point defects is hardly possible using standard characterization techniques, justifying the need for first-principles calculations. In this work, we have investigated the defect chemistry of most common solid electrolytes (LixM2(PO4)3 (M = Zr, Ti, Ge, Al), Li7La3Zr2O12, LiLaTi2O6, Li10Ge(PS6)2, Li7P3S11, Li3PS4, Li3PO4 and LiPO3). For each SE, we computed the formation energies for intrinsic defects and assessed the dopability limits as a function of the synthesis conditions. We found that the position of the Fermi level and dopability limits depend strongly on lithium and oxygen/sulfur chemical potentials but also on the nature of the solid electrolyte. We advocate that it is imperative to better regulate the synthesis conditions if we want to gain control over the formation of defects in solid electrolytes. The outcoming properties of these materials, such as the ionic and electronic conductivities, depend on it. [1] N. Dudney. Springer. 2003, 624-642. [2] E. Zhao et al. J. Alloys Comp. 2019. 782, 384-391. [3] Y. Song et al. J. Mat. Chem. A. 2019, 7(40), 22898-22902. [4] Y. Shan et al. J. Power Sources. 1995, 54(2), 397-402.

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12

Jayasooriya, Nishani, Sonia Saxena, Jonathan Blackwell, Alex Bottle, Hanna Creese, Irene Petersen, and Richard C. G. Pollok. "Associations between prior healthcare use, time to diagnosis, and clinical outcomes in inflammatory bowel disease: a nationally representative population-based cohort study." BMJ Open Gastroenterology 11, no. 1 (May 2024): e001371. http://dx.doi.org/10.1136/bmjgast-2024-001371.

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BackgroundTimely diagnosis and treatment of inflammatory bowel disease (IBD) may improve clinical outcomes.ObjectiveExamine associations between time to diagnosis, patterns of prior healthcare use, and clinical outcomes in IBD.DesignUsing the Clinical Practice Research Datalink we identified incident cases of Crohn’s disease (CD) and ulcerative colitis (UC), diagnosed between January 2003 and May 2016, with a first primary care gastrointestinal consultation during the 3-year period prior to IBD diagnosis. We used multivariable Cox regression to examine the association of primary care consultation frequency (n=1, 2, >2), annual consultation intensity, hospitalisations for gastrointestinal symptoms, and time to diagnosis with a range of key clinical outcomes following diagnosis.ResultsWe identified 2645 incident IBD cases (CD: 782; UC: 1863). For CD, >2 consultations were associated with intestinal surgery (adjusted HR (aHR)=2.22, 95% CI 1.45 to 3.39) and subsequent CD-related hospitalisation (aHR=1.80, 95% CI 1.29 to 2.50). For UC, >2 consultations were associated with corticosteroid dependency (aHR=1.76, 95% CI 1.28 to 2.41), immunomodulator use (aHR=1.68, 95% CI 1.24 to 2.26), UC-related hospitalisation (aHR=1.43, 95% CI 1.05 to 1.95) and colectomy (aHR=2.01, 95% CI 1.22 to 3.27). For CD, hospitalisation prior to diagnosis was associated with CD-related hospitalisation (aHR=1.30, 95% CI 1.01 to 1.68) and intestinal surgery (aHR=1.71, 95% CI 1.13 to 2.58); for UC, it was associated with immunomodulator use (aHR=1.42, 95% CI 1.11 to 1.81), UC-related hospitalisation (aHR=1.36, 95% CI 1.06 to 1.95) and colectomy (aHR=1.54, 95% CI 1.01 to 2.34). For CD, consultation intensity in the year before diagnosis was associated with CD-related hospitalisation (aHR=1.19, 95% CI 1.12 to 1.28) and intestinal surgery (aHR=1.13, 95% CI 1.03 to 1.23); for UC, it was associated with corticosteroid use (aHR=1.08, 95% CI 1.04 to 1.13), corticosteroid dependency (aHR=1.05, 95% CI 1.00 to 1.11), and UC-related hospitalisation (aHR=1.12, 95% CI 1.03 to 1.21). For CD, time to diagnosis was associated with risk of CD-related hospitalisation (aHR=1.03, 95% CI 1.01 to 1.68); for UC, it was associated with reduced risk of UC-related hospitalisation (aHR=0.83, 95% CI 0.70 to 0.98) and colectomy (aHR=0.59, 95% CI 0.43 to 0.80).ConclusionElectronic records contain valuable information about patterns of healthcare use that can be used to expedite timely diagnosis and identify aggressive forms of IBD.

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13

Hillmen, Peter, Sue Richards, and Daniel Catovsky. "Comparison of Oral and Intravenous Fludarabine in the LRF CLL4 Trial." Blood 106, no. 11 (November 16, 2005): 722. http://dx.doi.org/10.1182/blood.v106.11.722.722.

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Abstract The LRF CLL4 trial opened in 2/99 and closed in 10/04. 783 previously untreated patients with CLL requiring therapy by conventional criteria were entered and 6 were excluded. Patients were randomized between chlorambucil (10mg/m2 x 7 days; n=387) and fludarabine alone (FDR; n=194) or combined with cyclophosphamide (FC; n=196). A full report of the responses and outcomes of the trial will be presented elsewhere in the Meeting (Catovsky et al.). FDR and FC were initially given intravenously (IV; FDR 25mg/m2 x 5 days or FDR 25mg/m2 plus cyclophosphamide 250mg/m2 for 3 days) until 2001 when oral FDR became available and the protocol was modified to allow it’s use. The oral dose of fludarabine (FDR 40mg/m2 x 5 days or FDR 24mg/m2 plus cyclophosphamide 150mg/m2 for 5 days) was considered equivalent to the IV dose as previous studies indicated that the bioavailability of oral fludarabine was approximately 55% of the IV route. Dosing in the chlorambucil arm of the trial remained unchanged. The chemotherapy dose was reduced if there was a 2 week delay in therapy due to neutropenia or thrombocytopenia and the fludarabine dose was reduced if the creatinine clearance was between 30 to 60ml/min. 223 patients received oral FDR (107 FDR alone and 116 FC) and 106 patients received IV FDR (51 FDR alone and 55 FC). 6 FDR and 15 FC patients were not assessable for response. Among the remainder, responses were better with IV fludarabine compared to oral therapy (FDR: CR/NPR = 54% v 41%, NR = 8% v 26%, p=0.02; FC: CR/NR = 73% v 59%, NR = 2% v 10%, p=0.04). There was no difference between the oral and IV patients in age, gender or stage, but as expected the proportion receiving oral therapy increased over the years (2001 75%, 2002 85%, 2003 89%, 2004 91%; p for trend=0.008) and patients entered after 2001 were older (mean 64.4 versus 62.5; p=0.02). However the response rate also decreased by year of entry in the chlorambucil arm (1999/2000 vs 2001/02 vs 2003/04: CR/NPR = 33% vs 30% vs 20%; NR/PD = 17% vs 28% vs 38%, p=0.004) with no significant difference over time when the responses for the two fludarabine-containing regimes, including oral and IV, were combined (1999/2000 vs 2001/02 vs 2003/04: CR/NPR = 57% vs 51% vs 51%; NR/PD = 6% vs 13% vs 16%, p=0.16). In multivariate Cox regression analysis of progression free survival (PFS) for patients entered from 2001, including treatment (FDR or FC), age, gender, stage, year of entry and IV or oral FDR as possible variables in the model, treatment (p=0.0003) and IV/oral (Hazard ratio (HR) = 1.9; p=0.05) were significant. Age was the only significant variable in analysis of survival (HR = 1.05; p=0.0003). There was no significant difference in the main toxicities (neutropenia, thrombocytopenia, anaemia, nausea and vomiting, alopecia, diarrhoea) for oral or IV fludarabine. In summary, analysis of the data suggests that the observed difference in response rates between intravenous and oral fludarabine in the LRF CLL4 trial is probably not due to the route of administration of fludarabine but is more likely to be explained because older patients with a poorer prognosis were entered later in the study when all patients were guaranteed to receive oral therapy. Although a randomised controlled trial would be required to formally prove that oral fludarabine is not inferior to intravenous fludarabine our data are suggestive that there are unlikely to be significant differences in response rates between routes of administration of fludarabine.

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14

Linden, Anthony, Teresa de Haro, and Cristina Nevado. "[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]chloridogold(I)." Acta Crystallographica Section C Crystal Structure Communications 68, no. 1 (December 6, 2011): m1—m3. http://dx.doi.org/10.1107/s0108270111051365.

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The molecule of the title compound, [AuCl(C27H36N2)], which belongs to a class of potentially catalytically active N-heterocyclic carbene complexes, has crystallographicC2symmetry and approximateC2vsymmetry. The structure is isostructural with the CuIand AgIanalogues. A previous report of the structure of the title compound as its toluene solvate [Fructoset al.(2005).Angew. Chem. Int. Ed.44, 5284–5288] has inaccurate geometry for the complex molecule as a consequence of probable incorrect refinement in the space groupCc, instead ofC2/c[Marsh (2009).Acta Cryst.B65, 782–783]. The Au—C bond length of 1.998 (4) Å in the title compound is more consistent with the mean distance of 1.979 (14) Å found in 52 other reported [AuCl(carbene)] complexes than with the shorter distance of 1.942 (3) Å given for the refinement in the space groupCcfor the toluene solvate and the value of 1.939 Å obtained from the recalculation of that structure inC2/c.

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15

Alansari, Bader M. "INTERNAL CONSISTENCY OF AN ARABIC ADAPTATION OF THE BECK DEPRESSION INVENTORY-II WITH COLLEGE STUDENTS IN EIGHTEEN ARAB COUNTRIES." Social Behavior and Personality: an international journal 34, no. 4 (January 1, 2006): 425–30. http://dx.doi.org/10.2224/sbp.2006.34.4.425.

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This study examined the adequacy and consistency of the second edition of the Beck Depression Inventory using an Arabic version of the BDI-II developed by Ghareeb (2000). Coefficient alphas were computed for samples of male and female undergraduates recruited from Palestine, Lebanon, Syria, Jordan, Saudi Arabia, Kuwait, Qatar, Bahrain, U.A. Emirates, Oman, Yemen, Egypt, Sudan, Tunisia, Libya, Algeria and Morocco (n = 600, 270, 479, 841, 943, 780, 781, 356, 230, 360, 333, 590, 735, 275, 291, 298, 300, 706, respectively). Values of alpha ranged between .82-.93. The inventory seems viable in the Arabic context, its use in cross-cultural research may be explored.

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16

Jarczewska, Marta, Wiktor Bojarski, Aleksandra Majewska, Magdalena Mieczkowska, Marcin Drozd, Robert Ziolkowski, and Elżbieta Malinowska. "Application of Single-Stranded DNA and PNA Probes for Electrochemical Detection of miRNA 141." ECS Meeting Abstracts MA2022-01, no. 53 (July 7, 2022): 2239. http://dx.doi.org/10.1149/ma2022-01532239mtgabs.

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miRNA are known as short RNA molecules that usually consist of 18 – 25 nucleotides and are considered as posttranscriptional regulators of gene expression occurring in plants and animals [1]. Over 60% of all genes which encode proteins are controlled by miRNA [2]. miRNA is engaged in various processes including differentiation, proliferation and apoptosis as well as inflammation. Hence, they might be considered as potential biomarkers of diseases such as cancer, neurodegenerative and cardiovascular [3]. A huge challenge is the actual detection of miRNA because of their short length, low concentration and matrix interferences. The miRNA analysis can be performed with the following techniques such as real-time PCR, northern blotting and microarray [4-6]. However, the above mentioned techniques are rather sophisticated and are costly. An alternative could be the application of electrochemical techniques which are characterized with low detection limits, possibility of miniaturization and high sensitivity. In such a case miRNA could be detected using biosensors containing receptor layers formed of single-stranded DNA or PNA. Herein, we present the studies on the development of ssDNA/PNA – based receptor layers for the electrochemical analysis of miRNA 141, which is a biomarker of pancreatic cancer. Various receptor layers were tested including unlabelled ssDNA, methylene blue-labelled DNA as well as PNA-based. The formation of ssDNA/PNA receptor layer along with its binding to miRNA was confirmed using QCM and SPR techniques. The electrochemical studies revealed that it was not possible to obtain low detection limits for miRNA when MB-labelled ssDNA or PNA molecules were applied. On the contrary, detection limit of 10-4 nM was reached with the application of unlabelled ssDNA molecules. The further analysis showed the possibility of detection of point mutation in ssDNA or miRNA sequence as well as miRNA detection in spiked serum sample. Bibliography: [1] D. P. Bartel, Cell 116 (2004) 281–297 [2] A. Krek, D. Grun, M. N. Poy, R. Wolf, L. Rosenberg, E. J. Epstein, P. MacMenamin, I. da Piedade, K. C. Gunsalus, M. Stoffel, N. Rajewsky, N. Nat. Genet. 37 (2005) 495−500. [3] H. Hwang, J. T. Mendell, Br. J. Cancer 94 (2006) 776–780. [4] C. Chen, D. A. Ridzon, A. J. Broomer, Z. Zhou, D. H. Lee, J. T. Nguyen, M. Barbisin, N. L. Xu, V. R. Mahuvakar, M. R. Andersen, K. Q. Lao, K. J. Livak, K. J.Guegler, Nucleic Acids Res. 33 (2005) e179 [5] A. Valoczi, C. Hornyik, N. Varga, J. Burgyan, S. Kauppinen, Z. Havelda, Nucleic Acids Res. 32 (2004) e175 [6] A. M. Krichevsky, K. S. King, C. P. Donahue, K. Khrapko, K. S.Kosik, RNA 9 (2003) 1274−1281.

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17

MI, YONG-SHENG, CHUN-LAI MU, and DENG-MING LIU. "GLOBAL EXISTENCE AND BLOW-UP FOR A DOUBLY DEGENERATE PARABOLIC EQUATION SYSTEM WITH NONLINEAR BOUNDARY CONDITIONS." Glasgow Mathematical Journal 54, no. 2 (December 12, 2011): 309–24. http://dx.doi.org/10.1017/s0017089511000619.

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AbstractIn this paper, we deal with the global existence and blow-up of solutions to a doubly degenerative parabolic system with nonlinear boundary conditions. By constructing various kinds of sub- and super-solutions and using the basic properties of M-matrix, we give the necessary and sufficient conditions for global existence of non-negative solutions, which extend the recent results of Zheng, Song and Jiang (S. N. Zheng, X. F. Song and Z. X. Jiang, Critical Fujita exponents for degenerate parabolic equations coupled via nonlinear boundary flux, J. Math. Anal. Appl. 298 (2004), 308–324), Xiang, Chen and Mu (Z. Y. Xiang, Q. Chen, C. L. Mu, Critical curves for degenerate parabolic equations coupled via nonlinear boundary flux, Appl. Math. Comput. 189 (2007), 549–559) and Zhou and Mu (J. Zhou and C. L Mu, On critical Fujita exponents for degenerate parabolic system coupled via nonlinear boundary flux, Pro. Edinb. Math. Soc. 51 (2008), 785–805) to more general equations.

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18

Alansari, Bader M. "BECK DEPRESSION INVENTORY (BDI-II) ITEMS CHARACTERISTICS AMONG UNDERGRADUATE STUDENTS OF NINETEEN ISLAMIC COUNTRIES." Social Behavior and Personality: an international journal 33, no. 7 (January 1, 2005): 675–84. http://dx.doi.org/10.2224/sbp.2005.33.7.675.

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An Arabic version of the second edition of the Beck Depression Inventory (BDI-II) in its complete form was developed by Ghareeb (2000). The BDI-II was administered to 18 Islamic groups and the English version of the BDI-II (Beck, Steer, & Brown, 1996) was administered to an additional Pakistani group. Co-efficient alphas were computed for samples of male and female undergraduates recruited from 19 Islamic countries: Palestine, Lebanon, Syria, Iraq, Jordan, Saudi Arabia, Kuwait, Qatar, Bahrain, United Arab Emirates, Oman, Yemen, Egypt, Sudan, Tunisia, Libya, Algeria, Morocco and Pakistan (n=600, 270, 479, 841, 943, 780, 781, 356, 230, 360, 333, 590, 735, 275, 291, 298, 300, 706 and 532 respectively). The corrected item-total scale correlations of the BDI-II ranged between .21 and 89, the inventory seems viable in the Arabic context. Its use in cross-cultural studies would be suitable.

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19

Bernardo, Cristiane Hengler Corrêa, Sergio Silva Braga Júnior, Mauricio Dias Marques, Silvia Cristina Vieira Gomes, and Timóteo Ramos Queiroz. "Percepção dos produtores rurais de Tupã, SP, sobre o processo de comunicação para execução da logística reversa de embalagens de agrotóxicos." Revista Observatório 1, no. 3 (December 26, 2015): 242. http://dx.doi.org/10.20873/uft.2447-4266.2015v1n3p242.

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Disponível em: O artigo objetivou identificar a percepção de produtores rurais de Tupã/SP sobre a legislação que implantou e regulamenta a logística reversa de embalagens de agrotóxicos, bem como as informações que têm sobre sua obrigação. Buscou-se trazer elementos contidos na legislação e considerações de diversos autores, por meio de pesquisa bibliográfica, assim como foi aplicado um formulário com 19 questões, sobre o comportamento de 20 produtores rurais frente às informações relativas à devolução das embalagens vazias de agrotóxicos. As discussões revelam que cerca de 60% dos respondentes são indiferentes, conhecem muito pouco ou desconhecem sua responsabilidade como primeiro elo da cadeia da logística reversa das embalagens vazias de agrotóxicos, talvez em virtude de falhas no processo de comunicação e na fiscalização. Sugere-se que deva haver maior empenho do Poder Público com vistas a intensificar a fiscalização e tornar mais compreensível as responsabilidades desses agricultores.PALAVRAS-CHAVE: Logística reversa, comunicação e agronegócios, embalagens vazias de agrotóxicos, legislação ambiental. ABSTRACTWith the purpose to identify the perception of farmers Tupa/SP on legislation that established and governs the reverse logistics of empty pesticide containers, as well as the information they have on their obligation. It sought to bring elements contained in the legislation and considerations of various authors, through literature, as well as a form with 19 questions about the behavior of 20 farmers in the face of information on the release of empty containers of pesticides were applied. The discussions show that about 60% of respondents are indifferent, know little or unaware of their responsibility as first link in the chain of reverse logistics of empty pesticide containers, perhaps because of flaws in the communication process and inspection. It is suggested that there should be greater commitment from the Government in order to step up surveillance and make more understandable the responsibilities of farmers.KEYWORDS: Reverse logistics, communications and agribusiness, empty pesticide containers environmental legislation. RESUMENCon el propósito de identificar la percepción del agricultor Tupa / SP en la legislación que estableció y administra la logística inversa de los envases vacíos de plaguicidas, así como la información que tienen sobre su obligación. Se intentó traer elementos contenidos en la legislación y las consideraciones de diversos autores, a través de la literatura, así como un formulario con 19 preguntas sobre el comportamiento de los 20 agricultores en la cara de la información sobre la liberación de los envases vacíos de plaguicidas se aplicaron. Los debates muestran que alrededor del 60% de los encuestados son indiferentes, saben poco o conscientes de su responsabilidad como primer eslabón de la cadena de la logística inversa de los envases vacíos de plaguicidas, tal vez debido a fallas en el proceso de comunicación e inspección. Se sugiere que debe haber un mayor compromiso del Gobierno con el fin de intensificar la vigilancia y hacer más comprensibles las responsabilidades de los agricultores.PALABRAS CLAVE: Logística inversa, las comunicaciones y la agroindustria, los envases de plaguicidas vacíos de la legislación ambiental. ReferênciasAnonymous. IBGE investiga o meio ambiente de 5.560 municipios brasileiros. Source: IPS. NoticiasFinancieras, Miami, p. 1, May 16 2005.BERLO, David. O processo de comunicação: introdução à teoria e à prática. São Paulo: Martins Fontes, 2003.BIGATÃO, Daniely Aparecida Reveillau. Cuidados e destinação final de embalagens, na utilização de agrotóxicos por produtores rurais no município de Itaporã - MS. Dissertação (Mestrado em Ciências da Saúde)-Universidade de Brasília, 2009.BOLDRIN, Vitor Paulo et al. A Gestão Ambiental e a Logística Reversa no Processo de Retorno de Embalagens de Agrotóxicos Vazias. RAI - Revista de Administração e Inovação, São Paulo, v. 4, n. 2, p. 29-48, 2007.BRAGA JUNIOR, Walter; ROMANIELLO, Marcelo Marcio. Direito Ambiental: Percepção dos agentes envolvidos na destinação final das embalagens de agrotóxicos, de acordo com a Lei n. 9.974/00, na região cafeeira do município de Lavras, no sul de Minas Gerais. Gestão & Regionalidade (online), v. 24, n. 69, jan-abr/2008.BRASIL. Decreto nº 3.550, de 27/07/2000. Dá nova redação a dispositivos do Decreto no 98.816, de 11 de janeiro de 1990, que dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins. Disponível em < https://www.planalto.gov.br/ccivil_03/decreto/d3550.htm > Acesso em 12 mar. 2015.BRASIL. Decreto nº 3.694, de 21/12/2000. Altera e inclui dispositivos ao Decreto no 98.816 de 11 de janeiro de 1990, que dispõe sobre o controle e a fiscalização de agrotóxicos, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/decreto/D3694.htm > Acesso em 12 mar. 2015.BRASIL. Decreto nº 3.828, de 31/05/2001. Altera e inclui dispositivos ao Decreto no 98.816, de 11 de janeiro de 1990, que dispõe sobre o controle e a fiscalização de agrotóxicos e da outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/decreto/2001/D3828.htm > Acesso em 12 mar. 2015BRASIL. Decreto nº 4.074, de 04/01/2002. Regulamenta a Lei nº 7.802, de 11 de julho de 1989. Disponível em < https://www.planalto.gov.br/ccivil_03/decreto/2002/d4074.htm> Acesso em 12 mar. 2015.BRASIL. Decreto nº 98.816, de 11/01/1990. Regulamenta a Lei 7.802/1989 e dá outras providências. Disponível em < https://www.planalto.gov.br/ccivil_03/decreto/antigos/d98816.htm> Acesso em 12 mar. 2015.BRASIL. Lei Federal nº 12.305, de 02/08/2010. Institui a Política Nacional de Resíduos Sólidos; altera a Lei no 9.605, de 12 de fevereiro de 1998; e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/_ato2007-2010/2010/lei/l12305.htm> Acesso em 05 set. 2014.BRASIL. Lei nº 6.938, de 31/08/1981. Dispõe sobre a Política Nacional do Meio Ambiente, seus fins e mecanismos de formulação e aplicação, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/leis/l6938.htm > Acesso em 04 set. 2014.BRASIL. Lei nº 7.802/1989, de 11/07/1989. Dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins, e dá outras providências. Disponível em https://www.planalto.gov.br/ccivil_03/leis/l7802.htm Acesso em 03 fev. 2015.BRASIL. Lei nº 9.605, de 12/02/1998. Dispõe sobre as sanções penais e administrativas derivadas de condutas e atividades lesivas ao meio ambiente, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/leis/l9605.htm > Acesso em 27 mar. 2015.BRASIL. Lei nº 9.974, de 06/06/2000. Altera a Lei nº 7.802/1989, que dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins, e dá outras providências. Disponível em < http://www.planalto.gov.br/ccivil_03/leis/L9974.htm> Acesso em 12 mar. 2015.BRASIL. Resolução CONAMA nº 334, de 3 de abril de 2003. Dispõe sobre os procedimentos de licenciamento ambiental de estabelecimentos destinados ao recebimento de embalagens vazias de agrotóxicos. Disponível em < http://www.mma.gov.br/port/conama/legiabre.cfm?codlegi=356> Acesso em 20 mar. 2015.BRASIL. Resolução CONAMA nº 465, de 05/12/2014. Dispõe sobre os requisitos e critérios técnicos mínimos necessários para o licenciamento ambiental de estabelecimentos destinados ao recebimento de embalagens de agrotóxicos e afins, vazias ou contendo resíduos. Disponível em < http://www.mma.gov.br/port/conama/legiabre.cfm?codlegi=710> Acesso em 20 mar. 2015.CANTOS, Clotilde; MIRANDA, Zoraide Amarante I.; LICCO, Eduardo Antonio. Contribuições para a Gestão das Embalagens Vazias de Agrotóxicos. ©INTERFACEHS - Revista de Gestão Integrada em Saúde do Trabalho e Meio Ambiente - v.3, n.2, Seção Interfacehs 1, abr./ agosto. 2008 www.interfacehs.sp.senac.br.CARBONI, Gleriani Torres; SATO, Geni Satiko; MOORI, Roberto Giro. Logística Reversa para Embalagens de Agrotóxicos no Brasil: Uma Visão sobre Conceitos e Práticas Operacionais. XLIII CONGRESSO DA SOBER "Instituições, Eficiência, Gestão e Contratos no Sistema Agroindustrial". Ribeirão Preto, 24 a 27 de Julho de 2005.COMETTI, José Luís Said. Logística reversa das embalagens de agrotóxicos no Brasil: um caminho sustentável?. 2009. 152 f., il. Dissertação (Mestrado em Desenvolvimento Sustentável)-Universidade de Brasília, 2009.COSTA, Evandro. Política Nacional de Resíduos Sólidos / Logística Reversa. SIRECOM - Sindicato dos Representantes Comerciais do Paraná. Disponível em http://sirecompr.org.br/noticia/274/politica-nacional-de-residuos-solidos---logistica-reversa. Acesso em 03 set.2014.FARIA, Ana Cristina de; PEREIRA, Raquel da Silva. O Processo de Logística Reversa de Embalagens de Agrotóxicos: um estudo de caso sobre o INPEV. Organizações Rurais & Agroindustriais, Lavras, v. 14, n. 1, p. 127-141, 2012.GIL, Antonio Carlos. Métodos e Técnicas de Pesquisa Social. 6 ed. São Paulo: Atlas, 2014.GRUTZMACHER, Douglas Daniel et al. Embalagens Vazias de Agrotóxicos: organização dos fabricantes e suas obrigações (Lei Federal 9.974). R. Bras. Agrociência, Pelotas, v. 12, n. 1, p. 05-06, jan-mar, 2006.HAIR Jr, J. F.;MONEY, A. H.; BABIN, B.; SAMOUEL, P. Fundamentos de Metodos de Pesquisa Em Administraca. Bookman, 2005.LADEIRA, Wagner Junior; MAEHLER, Alisson Eduardo; NASCIMENTO, Luís Felipe Machado do. Logística reversa de defensivos agrícolas: fatores que influenciam na consciência ambiental de agricultores gaúchos e mineiros. Revista de Economia e Sociologia Rural, v. 50, n. 1, p. 157-174, 2012.LEITE, Paulo Roberto. Logística Reversa - Nova área da logística empresarial. Revista Tecnologística, maio/2002. São Paulo, Edit. Publicare.MARCONI, M.A.; LAKATOS, E.M. Metodologia Científica. 6.ed.São Paulo: Atlas, 2011.MARCONI, Marina de Andrade; LAKATOS, Eva Maria. Técnicas de Pesquisa. 7 ed. São Paulo: Atlas, 2010.MAZZA, V.M.D.S. et al. Gestão de Resíduos Sólidos em Propriedades Rurais de Municípios do Interior do Estado do Rio Grande do Sul. Revista em Agronegócio e Meio Ambiente, Maringá, v. 7, n. 3, p. 683-706, Sep 2014.MELO, Wederson Miranda et al. Logística Reversa de Embalagens de Agrotóxicos: um estudo de caso na cidade de Patos-MG. VIII Congresso Nacional de Excelência em Gestão, 8 e 9 de junho de 2012. ISSN 1984-9354.MILLER, Chad R.; SARDER, M. D. Public works policy implications of sustainable reverse logistics operations. Public Works Management & Policy, p. 1087724X11429044, 2011.MOTTA, Wladmir Henriques. Análise do Ciclo de Vida e Logística Reversa. X SEGeT 2013 Simpósio de Excelência em Gestão e Tecnologia. Gestão e Tecnologia para a Competitividade. 23,24,25 out/2013.MOURÃO, Renata Fernandes; SEO, Emília Satoshi Miyamaru. Logística reversa de lâmpadas fluorescentes. InterfacEHS Revista de Saúde, Meio Ambiente e Sustentabilidade. V. 7, N. 3, 2012.OLIVEIRA, Andréa Leda Ramos de; CAMARGO, Samira Gaiad Cibim de. Logística Reversa de Embalagens de Agrotóxicoss: identificação dos determinantes de sucesso. Interciencia, Caracas, v. 39, n. 11, p. 780-787, 11 2014.PESTANA, M. H.; GAGEIRO, J. N. Análise de dados para ciências sociais: a complementaridade do SPSS. 2003.SILVA, D.; LOPES, Evandro Luiz; BRAGA JUNIOR, S. S. Pesquisa Quantitativa: Elementos, Paradigmas e Definições. Revista de Gestão e Secretariado, v. 5, n. 1, p. 01-18, 2014.VEZZALI, F. Opiniao-A soja eleva risco de contaminacao de trabalhadores por agrotóxicos. Source: IPS. Noticias Financieras, Miami, p. 1, Jun 13 2006.VICTOR, P.T. Opiniao - Politica Nacional dos Residuos Solidos. Noticias Financieras, Miami Aug 24 2010.WOLF, S. A. Professionalization of agriculture and distributed innovation for multifunctional landscapes and territorial development. Agricultural Human Values, n. 25, p. 203-207, 2008. Disponível em:Url: http://opendepot.org/2708/ Abrir em (para melhor visualização em dispositivos móveis - Formato Flipbooks):Issuu / Calameo

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Kawano, Yoji, Takeshi Yoshimura, Daisuke Tsuboi, Saeko Kawabata, Takako Kaneko-Kawano, Hiromichi Shirataki, Tadaomi Takenawa, and Kozo Kaibuchi. "CRMP-2 Is Involved in Kinesin-1-Dependent Transport of the Sra-1/WAVE1 Complex and Axon Formation." Molecular and Cellular Biology 25, no. 22 (November 15, 2005): 9920–35. http://dx.doi.org/10.1128/mcb.25.22.9920-9935.2005.

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ABSTRACT A neuron has two types of highly polarized cell processes, the single axon and multiple dendrites. One of the fundamental questions of neurobiology is how neurons acquire such specific and polarized morphologies. During neuronal development, various actin-binding proteins regulate dynamics of actin cytoskeleton in the growth cones of developing axons. The regulation of actin cytoskeleton in the growth cones is thought to be involved in axon outgrowth and axon-dendrite specification. However, it is largely unknown which actin-binding proteins are involved in axon-dendrite specification and how they are transported into the developing axons. We have previously reported that collapsin response mediator protein 2 (CRMP-2) plays a critical role in axon outgrowth and axon-dendrite specification (N. Inagaki, K. Chihara, N. Arimura, C. Menager, Y. Kawano, N. Matsuo, T. Nishimura, M. Amano, and K. Kaibuchi, Nat. Neurosci. 4:781-782, 2001). Here, we found that CRMP-2 interacted with the specifically Rac1-associated protein 1 (Sra-1)/WASP family verprolin-homologous protein 1 (WAVE1) complex, which is a regulator of actin cytoskeleton. The knockdown of Sra-1 and WAVE1 by RNA interference canceled CRMP-2-induced axon outgrowth and multiple-axon formation in cultured hippocampal neurons. We also found that CRMP-2 interacted with the light chain of kinesin-1 and linked kinesin-1 to the Sra-1/WAVE1 complex. The knockdown of CRMP-2 and kinesin-1 delocalized Sra-1 and WAVE1 from the growth cones of axons. These results suggest that CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation.

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Cabrales Salazar, Omar. "LA EPISTEMOLOGÍA DEL SUJETO CONOCIDO Y LA CONCEPCIÓN DEL TRABAJO EN COLOMBIA." Itinerario Educativo 26, no. 59 (June 1, 2012): 53. http://dx.doi.org/10.21500/01212753.1461.

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Este artículo expone el marco metodológico de la tesis doctoral del autor. Plantea en primer lugar, como antecedentes, los cambios generados en el trabajo en el mundo occidental, desde el estado del bienestar hasta nuestros días, haciendo énfasis en los años de la globalización y el neoliberalismo y teniendo como referentes entre otros autores a Rifkin (2004), De la Garza (2001), Beck (2000), Gorz (1982) y Offe (1985). De la misma forma, cómo eventos que podrían crear categorías sociohistóricas importantes en la historia del trabajo en Colombia, se mencionan las tres reformas laborales promovidas por la ley 50 de 1990, la Ley 100 de 1993 y la Ley 789 de 2002. Posteriormente se hace referencia a la epistemología del sujeto conocido (Vasilachis, 2006) como fundamentación epistemológica que guía el trabajo de campo.

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Сауткин, Илья Сергеевич, та Татьяна Владимировна Рогова. "ВАРИАБИЛЬНОСТЬ ФУНКЦИОНАЛЬНЫХ ПРИЗНАКОВ ЛИСТЬЕВ НЕКОТОРЫХ ВИДОВ ЛУГОВЫХ РАСТЕНИЙ". Российский журнал прикладной экологии, № 1 (25 березня 2022): 4–14. http://dx.doi.org/10.24852/2411-7374.2022.1.4.14.

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Исследование внутривидовой изменчивости трех функциональных признаков листьев: площади – LA, сухой массы – LDW и удельной площади – SLA показало их взаимообусловленность и зависимость значений признаков от благопритяности условий местообитания и антропогенной нагрузки. Анализ полученных данных исследования показал, что универсальные информационные показатели LA и LDW являются низкими в неблагоприятных и низкопродуктивных местообитаниях и более высокими при изобилии ресурсов в более продуктивных условиях существования. Полученные значения SLA видов растений, произрастающих в сообществах интенсивно эксплуатируемых пастбищ, часто имеют более высокие значения. Возможно, адаптация в условиях постоянного изъятия биомассы на сенокосах и пастбищах идет в первую очередь через сокращение массы листьев при сохранении листовой поверхности. 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Kong, C. S., X. L. Qiu, K. S. Yi, X. F. Yu, and L. Yu. "First Report of Neofusicoccum vitifusiforme Causing Blueberry Blight of Blueberry in China." Plant Disease 94, no. 11 (November 2010): 1373. http://dx.doi.org/10.1094/pdis-05-10-0393.

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In May 2008, symptoms of blueberry blight were observed on half-high blueberry (Vaccinium corymbosum L.) in a plant nursery in Anning, Yunnan Province. Symptoms included dieback and bud and branch blight. Symptomatic plant samples were washed with running tap water, disinfected with 2% sodium hypochlorite and then 70% alcohol, rinsed in sterile distilled water, plated on potato dextrose agar (PDA), and incubated at 26°C. Conidia forming on PDA were hyaline, granular, fusoid to ellipsoid, widest in the upper third with an obtuse apex and flattened, subtruncate base, and 18 to 21 × 4.5 to 8 μm. The pathogen was also identified to the species level by sequencing the ribosomal internal transcribed spacer regions 1 and 2 (ITSI-5.8S-ITS2) and the translation elongation factor 1-alpha (EF1-α). BLAST searches at GenBank showed the highest nucleotide sequence identity with Neofusicoccum vitifusiforme reference sequence (ITS: >98%, EF638785; EF1-α: 100%, EF638744 and AY343343). Representative sequences of isolates from both regions were deposited in GenBank (ITS: Accession No. HM131604; EF1-α: Accession No. HM454277). Pathogenicity tests were conducted on 2-year-old blueberry seedlings (half-high blueberry). Mycelial plugs (3 mm in diameter) of N. vitifusiforme from actively growing colonies (PDA) were applied to same-size bark wounds in the center of the stems. Inoculation wounds were wrapped with Parafilm. Control seedlings received sterile PDA plugs. Inoculated and control seedlings (five each) were kept in a greenhouse and watered as needed. After 2 weeks, all of the inoculated but none of the control blueberry seedlings showed dark vascular stem tissue. N. vitifusiforme was reisolated from symptomatic tissues, thus fulfilling Koch's postulates. N. vitifusiforme has been reported as a pathogen of olive (2), plum, peach (1), and grapevine (3). To our knowledge, this is the first report of N. vitifusiforme on blueberry in China as well as worldwide. References: (1) U. Damm et al. Mycologia 99:664, 2007. (2) C. Lazzizera et al. Plant Pathol. 57:948, 2008. (3) J. M. van Niekerk et al. Mycologia 96:781, 2004.

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Czapiuk, Alina. "N. V. Riasanovsky, M. D. Steinberg, "Historia Rosji", wyd. 1, Kraków 2009, ss. 789." Białostockie Teki Historyczne 7 (2009): 206–11. http://dx.doi.org/10.15290/bth.2009.07.17.

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Borda, Bernadett, Edit Szederkényi, Csaba Lengyel, Tamás Várkonyi, Zoltán Hódi, Éva Kemény, Viktor Szabó, and György Lázár. "T-sejt-mediált rejectio gyakorisága vesetranszplantáció után, újonnan kialakult diabetes mellitusban." Orvosi Hetilap 156, no. 19 (May 2015): 785–89. http://dx.doi.org/10.1556/650.2015.30125.

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Introduction: New-onset diabetes is one of the most common complications after kidney transplantation. Aim: The aims of the authors were to examine the frequency of new-onset diabetes mellitus in kidney transplanted patients receiving cyclosporine A (n = 95) and tacrolimus (n = 102) and to analyze the occurrence of T-cell mediated rejection in these two groups of patients. Method: Age, laboratory results, renal function and histological findings were evaluated one year after kidney transplantation. Histological evaluation was performed according to the 2007 modification of the Banff 1997 classification. Results: New-onset diabetes developed in 12% of patients receiving cyclosporine A-based immunosuppression and in 24% of patients taking tacrolimus (p = 0.002). Uric acid level (p = 0.002) and the age of the recipient (p = 0.003) were significantly different in the new-onset diabetic and non-diabetic groups, while renal function showed no significant difference. Evaluation of tissue samples revealed a significant difference in T-cell mediated rejection between the new-onset diabetic and non-diabetic groups (13 vs. 8 patients; 37% vs. 6%; p = 0.001). Conclusions: The results indicate an early development of the pathological effect of new-onset diabetes after kidney transplantation on the morphology of the renal allograft. Orv. Hetil., 2015, 156(19), 785–789.

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Nobari, Tabashir Z., Shannon E. Whaley, Catherine M. Crespi, Michael L. Prelip, and May C. Wang. "Widening socio-economic disparities in early childhood obesity in Los Angeles County after the Great Recession." Public Health Nutrition 21, no. 12 (April 2, 2018): 2301–10. http://dx.doi.org/10.1017/s1368980018000666.

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AbstractObjectiveWhile economic crises can increase socio-economic disparities in health, little is known about the impact of the 2008–09 Great Recession on obesity prevalence among children, especially low-income children. The present study examined whether socio-economic disparities in obesity among children of pre-school age participating in a federal nutrition assistance programme have changed since the recession.DesignA pre–post observational study using administrative data of pre-school-aged programme participants from 2003 to 2014. Logistic regression was used to examine whether the relationship between obesity prevalence (BMI≥95th percentile of the Centers for Disease Control and Prevention’s growth charts) and three measures of socio-economic status (household income, household educational attainment, neighbourhood-level median household income) changed after the recession by examining the interaction between each socio-economic status measure and a 5-year time-period variable (2003–07 v. 2010–14), stratified by child’s age and adjusted for child’s sociodemographic characteristics.SettingLos Angeles County, California, USA.SubjectsChildren aged 2–4 years (n 1 637 788) participating in the Special Supplemental Nutrition Program for Women, Infants, and Children.ResultsThe magnitude of the association of household income and household education with obesity increased after 2008–09 among 3- and 4-year-olds and 2- and 3-year-olds, respectively. However, the magnitude of the association of neighbourhood-level median household income with obesity did not change after 2008–09.ConclusionsDisparities in obesity by household-level socio-economic status widened after the recession, while disparities by neighbourhood-level socio-economic status remained the same. The widening household-level socio-economic disparities suggest that obesity prevention efforts should target the most vulnerable low-income children.

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Ramsey, Scott D., Cara L. McDermott, Sara J. Beck, Jose A. Lopez, Stephen C. Dinwiddie, and Jeannine S. McCune. "Blood Product Use in Recently Diagnosed Persons with Myelodysplastic Syndrome: A Population Study." Blood 114, no. 22 (November 20, 2009): 4849. http://dx.doi.org/10.1182/blood.v114.22.4849.4849.

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Abstract Abstract 4849 Many patients with myelodysplastic syndrome (MDS) experience cytopenias that require blood product support. The extent to which MDS patients utilize blood products following diagnosis is unknown. The objective of this study was to characterize the use of blood products among recently diagnosed MDS patients in western Washington State. Records from the NCI's Surveillance, Epidemiology, and End Results (SEER) cancer registry for western Washington State were searched for patients diagnosed with MDS between 2001 and 2007. These records were linked to Puget Sound Blood Center (PSBC) database records. The PBSC is the major supplier of blood products for the Washington SEER region. SEER identified a total of 781 newly diagnosed patients during 2001-2007. The average age was 72.84, 76% were over age 65 and 55% were over age 75. Fifty-eight percent were male and 88% were white race. The most common MDS subtypes included refractory anemia (24%) and refractory anemia with excess blasts (21%); 33% had no specified subtype. Three hundred seventy-six patients (48%) received at least one blood product within 12 months of diagnosis; packed red blood cells (RBCs) (n=361 persons) and platelets (n=222 persons) were most commonly transfused. Among those receiving at least one transfusion of RBCs or one transfusion of platelets respectively, patients received an average of 15.40 units of RBCs and 15.37 units of platelets over 12 months from diagnosis; of these patients, the highest quartile used an average of 39.84 RBCs and 33.81 platelets per person. The proportion of MDS patients receiving any RBCs within 12 months of diagnosis increased from 24% in 2001 to 54% in 2007. Platelet use within 12 months of diagnosis increased from 12% of patients in 2001 to 39% in 2007. Among those receiving at least one platelet transfusion or at least one red blood cell transfusion within 12 months of diagnosis the number of products transfused increased over time, from an average of 8.00 platelet units (SD 5.77) and 8.85 units of RBCs (SD 11.21) in 2001 to 14.12 platelet units (SD 20.31) and 15.98 units RBCs (SD 19.35) in 2007 (p<0.0001, p<0.0001, respectively). Approximately half of newly diagnosed MDS patients receive at least one blood product in the first 12 months following diagnosis. Blood product use has increased substantially from 2001 to 2007, in terms of both the proportion of patients receiving them and the number of transfusions per person. Further study is needed to determine the factors leading to more aggressive use of blood products in these patients. Disclosures No relevant conflicts of interest to declare.

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Richette, Pascal, Pierre Clerson, Laure Périssin, René-Marc Flipo, and Thomas Bardin. "Revisiting comorbidities in gout: a cluster analysis." Annals of the Rheumatic Diseases 74, no. 1 (October 9, 2013): 142–47. http://dx.doi.org/10.1136/annrheumdis-2013-203779.

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ObjectivesThe reciprocal links between comorbidities and gout are complex. We used cluster analysis to attempt to identify different phenotypes on the basis of comorbidities in a large cohort of patients with gout.MethodsThis was a cross-sectional multicentre study of 2763 gout patients conducted from November 2010 to May 2011. Cluster analysis was conducted separately for variables and for observations in patients, measuring proximity between variables and identifying homogeneous subgroups of patients. Variables used in both analyses were hypertension, obesity, diabetes, dyslipidaemia, heart failure, coronary heart disease, renal failure, liver disorders and cancer.ResultsComorbidities were common in this large cohort of patients with gout. Abdominal obesity, hypertension, metabolic syndrome and dyslipidaemia increased with gout duration, even after adjustment for age and sex. Five clusters (C1–C5) were found. Cluster C1 (n=332, 12%) consisted of patients with isolated gout and few comorbidities. In C2 (n=483, 17%), all patients were obese, with a high prevalence of hypertension. C3 (n=664, 24%) had the greatest proportion of patients with type 2 diabetes (75%). In C4 (n=782, 28%), almost all patients presented with dyslipidaemia (98%). Finally, C5 (n=502, 18%) consisted of almost all patients with a history of cardiovascular disease and renal failure, with a high rate of patients receiving diuretics.ConclusionsCluster analysis of comorbidities in gout allowed us to identify five different clinical phenotypes, which may reflect different pathophysiological processes in gout.

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Hung, Tran Trong, Tran Anh Tu, Dang Thuong Huyen, and Marc Desmet. "Presence of trace elements in sediment of Can Gio mangrove forest, Ho Chi Minh city, Vietnam." VIETNAM JOURNAL OF EARTH SCIENCES 41, no. 1 (January 8, 2019): 21–35. http://dx.doi.org/10.15625/0866-7187/41/1/13543.

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Can Gio mangrove forest (CGM) is located downstream of Ho Chi Minh City (HCMC), situated between an estuarine system of Dong Nai - Sai Gon river and a part of Vam Co river. The CGM is the largest restored mangrove forest in Vietnam and the UNESCO’s Mangrove Biosphere Reserve. The CGM has been gradually facing to numeric challenges of global climate change, environmental degradation and socio-economic development for the last decades. To evaluate sediment quality in the CGM, we collected 13 cores to analyze for sediment grain size, organic matter content, and trace element concentration of Cd, Cr, Cu, Ni, Pb, Zn. Results showed that trace element concentrations ranged from uncontaminated (Cd, Cu, and Zn) to very minor contaminated (Cr, Ni, and Pb). The concentrations were gradually influenced by suspended particle size and the mangrove plants.ReferencesAnh M.T., Chi D.H., Vinh N.N., Loan T.T., Triet L.M., Slootenb K.B.-V., Tarradellas J., 2003. 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Retrieved from Water Resources Planning: http://siwrp.org.vn/tin-tuc/quy-hoach-tai-nguyen-nuoc-luu-vuc-song-dong-nai_143.html.Tuan L.D., Oanh T.T., Thanh C.V., Quy N.D., 2002. Can Gio mangrove biosphere reserve. HCM city, Vietnam: Agriculture Publisher.Tue N.T., Quy T.D., Amono A., 2012. Historical profiles of trace element concentrations in Mangrove sediments from the Ba Lat estuary, Red river, Vietnam. Water, Air & Soil Pollution, ISSN 0049-6979, 223(3), 1315-1330.Twilley R., Chen R., Hargis T., 1992. Carbon sinks in mangroves and their implications to carbon budget of tropical coastal ecosystems. Water, Air & Soil pollution, Netherland, 64, 265-288.UN Environment Program, 2006. Methods for sediment sampling and analysis. Palermo (Sicily), Italy: United Nation Environment Program.UNESCO, 2000. List of Biosphere reserves approved by MAB committee belonging to UNESCO. 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The Annual Review of Marine Science, 8, 243-266.Zhang J., Liu C.L., 2002. Riverine Composition and Estuarine Geochemistry of Particulate Metals in China-Weathering Features, Anthropogenic Impact and Chemical Fluxes. Estuarine, Coastal and Shelf Science, 54(6), 1051-1070.Zhang W., Feng H., Chang J., Qu J., Xie H., Yu L., 2009. Heavy metal contamination in surface sediments of Yangtze River intertidal zone: An assessment from different indexes. Environmental Pollution, 157, 1533-1543.Zheng W.-j., Xiao-yong C., Peng L., 1997. Accumulation and biological cycling of heavy metal elements in Rhizophora stylosa mangroves in Yingluo Bay, China. Marine ecology progress series, 159, 293-301.

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Okpala, Iheanyi, Cynthia C. Ugochukwu, Panagiotis Pantelidis, Baba Inusa, Obike Ibegbulam, and Onyinye Onyekwere. "Report on the International Co-Operative Study of the Effects of L-Selectin Gene Polymorphisms on the Development of Complications in Sickle Cell Disease." Blood 106, no. 11 (November 16, 2005): 3775. http://dx.doi.org/10.1182/blood.v106.11.3775.3775.

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Abstract Our previous study showed that patients with sickle cell disease (SCD) and high steady-state expression of the adhesion molecules L-selectin and αMβ2 integrin on leukocytes developed complications [Blood. 2002;100(suppl):11a. Eur J. Haematol. 2002; 69:135–144]. The aim of this study was to find out if L-selectin protein expression by leukocytes and the development of complications in SCD are affected by previously described single nucleotide polymorphisms within the coding regions of the gene. To detect F206L, T49S and P213S polymorphisms we determined the L-selectin genotype in 142 HbSS patients (64M, 78F, age 2 – 62 yr, mean 27 yr ±12); and 102 racially-matched HbAA controls with similar age and sex distribution. The T49S and P213S amino acid changes in L-selectin are respectively associated with increased risk of vasculopathy and nephropathy; important features of SCD. [Hum Genet. 1996; 97:15–20. Am. J. Hum. Genet.2002; 70: 781–786]. All HbSS patients were evaluated for disease complications. Steady-state expression of L-selectin on neutrophils, lymphocytes and monocytes was measured by flow cytometry in 44 HbSS patients. With respect to F206L polymorphism, 100/142 (70%) patients and 73/102 (72%) controls were FF homozygous, 42 patients and 28 controls were heterozygous FL, and 1 control individual was LL homozygous. There was no significant difference in distribution of the polymorphic variants between patients and controls [Chi-squared (X2) = 0.1, p>0.05]. In codon 213, 48 (33.8%) patients and 42 (41.2%) controls were PP homozygous, 91 patients and 55 controls PS heterozygous, 1 patient and 5 controls SS homozygous [X2 =1.9, p>0.05]. With regard to the T49S polymorphism, 100% of the patients and controls were TT homozygous. At least one complication of SCD was observed in 110 SCD patients; 32 had uncomplicated disease. The most common complications observed were avascular joint necrosis (n=39), sickle nephropathy (n=31), stroke (n=25) and acute chest syndrome (n=20). The observed frequencies of FF genotype in codon 206 among patients with complications (74), and without complication (26) were not significantly different from the expected values [X2 = 2.37, p>0.05]. Similarly, none of the other genotypes (FL, PP, PS) was significantly associated with complications of SCD. Of the 44 patients in who leukocyte L-selectin expression was measured, 31 turned out to be FF homozygous in codon 206, and 13 FL. No significant differences were observed between FF and FL patients in the mean levels of L-selectin expression by neutrophils (FF: 4.00+ 4.56 vs FL: 3.24+ 3.4), monocytes (FF: 4.30+ 5.6 vs FL: 2.56+ 3.39) or lymphocytes (FF: 2.61+ 3.02 vs FL: 2.11+ 2.0); p>0.05. Similarly, the P213S polymorphism had no effect on the level of L-selectin expression. The findings suggest that neither F206L nor P213S L-selectin gene polymorphism predisposes to high leukocyte surface expression of this adhesion molecule, or the development of complications in SCD.

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Chandra, S., A. T. Tong, A. Wei Wei, S. W. Yusuf, S. Javaid, D. Liu, J. Durand, and D. J. Lenihan. "Significance of stress myocardial perfusion scans in predicting cardiovascular events and mortality in cancer patients." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 17009. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.17009.

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17009 Background: Cardiac risk assessment in cancer patients has not extensively been studied. We evaluated the role of stress myocardial perfusion scan (SMPS) in predicting cardiovascular outcomes in cancer patients. Methods: A retrospective chart review was performed on 787 patients who had a SMPS from 01/2002 - 03/2003. All patients were followed for at least 1.5 years. Cox proportional hazard model was used to determine the time-to-first event [cardiac death, myocardial infarction (MI) and coronary revascularization]. Cardiac death was defined as documented cardiac death or sudden unexplained death. Results: A total of 501/787 (64%) patients had normal SMPS, whereas 286/787 (36%) had abnormal SMPS. Adenosine [430/787 (55%)] and dobutamine [144/787 (14%)] were used for chemical stress while 213/787 (23%) patients underwent exercise testing. Mean age was 66±11 years and median follow-up duration was 1.8 years. The 3- year event-free survival rate was 0.71 (0.64–0.78) for abnormal SMPS and 0.87 (0.8–0.94) for normal SMPS (p<0.0001). Of all abnormal scans (n=286), 3-year event free-survival rate based on type of vascular defects varied from 0.79(0.67–0.93) for fixed defects, 0.68 (0.58-.08) for reversible defects and 0.63 (0.5–0.8) for co-existent fixed and reversible defects (p<0.0001). Other factors adversely affecting event-free survival were male gender (p=0.025), cardiomyopathy (p=0.001), coronary artery disease (p<0.0001), previous MI (p<0.0001), congestive heart failure (p=0.001) and hypercholesterolemia (p<0.0001). When we analyzed cardiac death as a separate event, SMPS results still made a significant difference with 3-year cardiac-survival rate of 0.79 (0.69–0.91) for abnormal scan group versus 0.88 (0.81–0.95) for normal scan group (p=0.05). Furthermore, the 3-year cardiac-survival rate in patients with both fixed and reversible defects was 0.4 (0.1–1), which was much worse than those with fixed [0.87 (0.76–0.99)] or reversible [0.85 (0.74–0.99)] defects alone (p=0.028). Conclusions: SMPS is a highly useful modality for predicting cardiac events and mortality in cancer patients. The characteristics of the perfusion defect further stratifies the patients at higher risk. No significant financial relationships to disclose.

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Ibáñez Beltrán, Luis Manuel. "Las devociones que porfían: la estabilildad en las advocaciones parroquiales de la Tierra de Lemos (Lugo) en la Edad Media." Vínculos de Historia Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 12 (June 28, 2023): 238–60. http://dx.doi.org/10.18239/vdh_2023.12.12.

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RESUMENLa Tierra de Lemos es una comarca gallega del sur de la provincia de Lugo, heredera en lo sustantivo de un territorium y una terra medievales, a su vez continuadoras del solar protohistórico de los Lemaui. La continuidad en sus realidades permite el estudio de la evolución espiritual de sus células básicas de poblamiento: las parroquias. Las advocaciones, invariables en muchos casos, modificadas en otros, son así sillares en el edificio histórico del territorio. En este artículo estudiamos la evolución del listado de devociones titulares de las feligresías de Lemos a través de la documentación medieval, y la información que la estabilidad y los cambios nos pueden ofrecer. Palabras clave: parroquia, advocacionesTopónimos: Lemos, Lugo, GaliciaPeríodo: siglo vi, siglo xv ABSTRACTThe county of Lemos is a district located in the south of the province of Lugo. Its origins go back to protohistory when it was occupied by the Lemavi tribe, and it subsequently became a territorium and a terra in the Middle Ages. The county’s history is marked by continuity, which allows us to study the spiritual evolution of its parishes. The saints chosen by the community as its protectors are historic testimonials of the time. In this paper, we study the list of church parish devotions in Lemos through medieval documentation. Our objective is to improve our knowledge about this medieval county by studying both the stability and changes in its parish saints. Keywords: parish, advocationPlace names: Lemos, Lugo, GaliciaPeriod: 6th century, 15th century REFERENCIASAndrade Cernadas, J. M., O tombo de Celanova, Estudio introductorio, edición e índices (siglos ix-xii), Santiago de Compostela, Consello da Cultura Galega, 1995, 2 vols.Ares Vázquez, N., “Toponimia do concello do Saviñao”, Lucensia, miscelánea de cultura e investigación, 6, 13 (1996), pp. 47-68.— “Toponimia do concello da Pobra do Brollón”, Lucensia: miscelánea de cultura e investigación, 17, 35 (2007), pp. 241-262. — “Toponimia do concello de Pantón”, Lucensia: miscelánea de cultura e investigación, 20, 41 (2010), pp. 258-259. F. Arias Vilas, F., “O patrimonio cultural galego e o seu reflexo nas terras do Saviñao”, Circulo Polo Saviñao III, Escairón, Círculo Cultural Recreativo Saviñao, 2011, pp. 231-244. Arízaga Castro, A. y Ayán Vila, X. M., “Etnoarqueología del paisaje castreño: la segunda vida de los castros”, en Los pueblos de la Galicia céltica, Madrid, Akal, 2007, pp. 510-515. Armada Pita, X. L., “El culto a santa Eulalia y la cristianización de Gallaecia. Algunos testimonios arqueológicos”, Habis, 34 (2003), pp. 365-388. Aubrun, M., La paroisse en France : des origines aux XVe siècle, Paris, Éditions A. et J. Picard, 2008 (2.ª Ed).Ayán Vila, X. M., “Etnoarqueoloxía e microhistoria dunha paisaxe cultural: aparroquia de San Pedro de Cereixa (Pobra de Brollón, Lugo)”, Cuadernos de Estudios Gallegos, LII, 118 (2005), Santiago de Compostela, pp. 135-136. — “Os castros despois dos castros: un espazo simbólico na paisaxe rural tradicional galega”, en P. Ballesteros Arias (coord.), Encontros coa Etnografía, Noia, Toxosoutos, 2005, pp. 74–106. Baliñas Pérez, C., “As orixes altomedievais da Terra de Lemos”, en López Carreira, A., O condado de Lemos na Idade Media, I Simposio de Historia en Terra de Lemos, Santiago de Compostela, Xunta de Galicia, Consellería de Innovación e Industria, Dirección Xeral de Turismo, 2008, pp. 17-24. Bermúdez Belloso, M., Ibáñez Beltrán, L. M., “Una cartografía para los once condados de la diócesis de Lugo: hacia una nueva aproximación al Parrochiale Suevum”, Vínculos de Historia, 9 (2020), pp. 181-201. Cal Pardo, E., Colección diplomática medieval do arquivo da catedral de Mondoñedo: transcripción íntegra dos documentos, Santiago de Compostela, Consello da Cultura Galega. Sección de Patrimonio Histórico, 2005 (2.ª Ed). Calleja Puerta, M., “La delimitación entre las diócesis de Lugo y Oviedo. Escritura diplomática y territorialidad diocesana a mediados del siglo xii”, Hispania Sacra, LXXI, 143 (2019), pp. 39-57. Cañizares del Rey, V., “Advocaciones de iglesias que se mencionan desde el siglo viii al xiv inclusive como pertenecientes a la diócesis de Lugo”, Lucensia. Miscelánea de cultura e investigación, XV, 30 (2005), pp. 159-192. — Colección diplomática, Lugo, publicaciones de la Diócesis de Lugo, 2012-2016, 4vols. Castillo Maldonado, P., Los mártires hispanorromanos y su culto en la Hispania de la Antigüedad Tardía, Granada, Universidad de Granada, 1999. Castro Redondo, R., Medir y delimitar en un mundo impreciso: conflictos entre vecinos por medidas y límites en la Galicia moderna, Tesis doctoral dirigida por O. Rey Castelao, Santiago de Compostela, Universidade de Santiago de Compostela, 2016.Delgado Borrajo M., Grande Rodríguez, M., “Os lemavi a través das fontes literarias e epigráficas”, Minius: revista do departamento de Historia, Arte e Xeografía, n. 16 (2008), pp. 133-162. Delgado Gómez, J., “Los muy interesantes restos histórico-arqueológicos de la que fue la iglesia de San Pedro de Cela’’, Circulo Polo Saviñao III, Escairón, Círculo Cultural Recreativo Saviñao, 2010, pp. 212-219. Duro Peña, E., El monasterio de San Esteban de Ribas de Sil, Ourense, Instituto de estudios orensanos Padre Feijoo de la Diputación Provincial, 1977. Fariña Jamardo, X., A parroquia rural en Galicia, Santiago de Compostela, EGAP, 1996. Fernández Conde, F. J., La religiosidad medieval en España: Alta Edad Media (siglo vii-x), Oviedo, Universidad de Oviedo. Servicio de publicaciones, 2000. Fernández de Viana y Vieites, J. I., Colección diplomática del monasterio de Ferreira de Pantón, Lugo, Exma. Deputación Provincial de Lugo, 1994.Fernández López, A., El monasterio cisterciense de Santa María de Castro de Rey (Paradela), Lugo, Servicio de publicaciones de la diputación provincial, 2006.Fernández Suárez, E., El monasterio de Santa Cristina de Ribas de Sil, trabajo de licenciatura dirigido M. Lucas Álvarez, Santiago de Compostela, Universidade de Santiago de Compostela, 1958, 2 vols.García Conde, A., “El obispo Odoario: datos de su vida a la luz de un documento del 954”, Boletín de la Comisión Provincial de Monumentos Históricos y Artísticos de Lugo, I, 2 (1942), pp. 25-29. García Rodríguez, C., El culto de los santos en la España romana y visigoda, Madrid, CSIC, 1966. González, T., Censo de población de las provincias y partidos de la Corona de Castilla en el siglo xvi: con varios apéndices, Madrid, Imprenta Real, 1829, https://bibliotecadigital.jcyl.es/es/consulta/registro.cmd?id=7823 (Consulta: 1-04-2022).González Reboredo, X. M., Os santos titulares de parroquia en Galiza: pasado, presente e perspectivas de futuro, Santiago de Compostela, Sotelo Blanco, 2012. Ibáñez Beltrán, L. M., La villa de Monforte y la Tierra de Lemos en la Edad Media, tesis doctoral dirigida por F. López Alsina, Santiago de Compostela, Universidade de Santiago de Compostela, 2020.López Alsina, F., “La articulación de las unidades de organización social del espacio en Galicia durante la Edad Media: Villa, Parroquia, Terra”, en Sesma Muñoz, J. A. y Laliena Corbera, C. (coorda.), La pervivencia del concepto: Nuevas reflexiones sobre la ordenación social del espacio en la Edad Media, Zaragoza, Universidad de Zaragoza, 2008.— “Da protoparroquia ou parroquia antiga altomedieval á parroquia clásica en Galicia”, en García Pazos, F. (ed.), A parroquia en Galicia: pasado, presente e futuro, Santiago de Compostela, Xunta de Galicia, 2009, pp. 57-75. — “El Parrochiale Suevum y su presencia en las cartas pontificias del siglo xii”, en Herbers, K., Engel, F., y López Alsina, F. (eds.), Das begrenzte Papsttum: Spielräume päpstlichen Handelns, Legaten, delegierte Richter, Grenzen, Berlín, De Gruyter, 2013, pp. 105-118. López Sangil, J. L., Vidán Torreira, M., “El Tumbo Viejo de Lugo”, Estudios Mindonienses. Anuario de estudios histórico-teológicos de la Diócesis de Mondoñedo-Ferrol, 27 (2011), pp. 11-373. Lorenzo Vázquez, R., Colección documental do mosteiro de Montederramo, Santiago de Compostela, Consello da Cultura Galega, 2016, 3 vols. Lucas Álvarez, M., El tumbo de San Julián de Samos (siglos xvii-xii): Estudio introductorio. Edición diplomática. Apéndices e índices, Santiago de Compostela,Caixa Galicia, 1986. — San Paio de Antealtares, Soandres y Toques: tres monasterios medievales gallegos, Sada, Ediciós do Castro, 2001. Lucas Álvarez, M. y Lucas Domínguez, P., El priorato benedictino de San Vicenzo de Pombeiro y su colección diplomática en la Edad Media, Sada, Ediciós do Castro, 1996.Menéndez de Luarca y Navia Ossorio, J. R., A construçâo do território: Mapa histórico do noroeste da Península Ibérica, Barcelona, Lunwerg, 2000. Moure Pena, T. C., “Precisiones históricas sobre el monasterio cisterciense de San Salvador de Ferreira de Pantón (Lugo) a partir de nuevos testimonios documentales y arqueológicos”, Cisterium (separata), 55, 231 (2003), pp. 365-389.Portela Silva, M. X., Documentos da catedral de Lugo, século xv, Santiago de Compostela, Consello da Cultura Galega, 2005. — Documentos da catedral de Lugo: século xiv, Santiago de Compostela, Consello da Cultura Galega, 2007, 2 vols. Rodríguez Fernández, C., La colección diplomática de San Vicente del Pino, Tesis doctoral dirigida por J. I. Fernández de Viana y Vieites, Granada, Universidad de Granada, Facultad de Filosofía y letras, 1990. Romaní Martínez, M. (dir.), Colección diplomática do mosteiro Cisterciense de Santa María de Oseira (Ourense), Santiago de Compostela, Tórculo Edicións, 1990-2008, 5 vols.Sáez Sánchez, E., Sáez, C., Colección diplomática del Monasterio de Celanova (842-1230), Alcalá de Henares, Universidad de Alcalá de Henares, 1996-2006, 3 vols.Sánchez Pardo, J. C., “Topónimos y advocaciones: la información histórica en los nombres de las parroquias rurales gallegas”, Minius, 20 (2012), pp. 187-226. — “Organización eclesiástica y social en la Galicia tardoantigua. Una perspectiva geográfico-arqueológica del parroquial suevo”, Hispania Sacra, LXVI, 134 (2014), pp.439-480. Solano Fernández-Sordo, A., “Extra Archam: santa Eulalia en Oviedo. Viajes dereliquias, thesaurum y legitimación del poder”, Anuario de Historia de la Iglesia, 29 (2020), pp. 311-346. Stylow, A. U., “El culto a san Miguel en la Hispania visigoda: una revisión crítica”, en Guerra y rebelión en la Antigüedad Tardía: el siglo vii en España y su contexto mediterráneo, actas de los 4º y 5º Encuentros Internacionales Hispania en la Antigüedad Tardía, Alcalá de Henares, Universidad de Alcalá/Excmo. Ayuntamiento de Alcalá de Henares, 2005, pp. 213-224.Vázquez Saco, F., “Papeleta 76. Iglesia parroquial de San Pelagio de Diomonde”, Boletín de la Comisión Provincial de Monumentos de Lugo, II (1945), pp. 270-276.

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Sdiri-Loulizi, Khira, Katia Ambert-Balay, Hakima Gharbi-Khelifi, Mouna Hassine, Slaheddine Chouchane, Nabil Sakly, Mohamed Neji-Guédiche, Pierre Pothier, and Mahjoub Aouni. "Molecular epidemiology and clinical characterization of group A rotavirus infections in Tunisian children with acute gastroenteritis." Canadian Journal of Microbiology 57, no. 10 (October 2011): 810–19. http://dx.doi.org/10.1139/w11-074.

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Rotaviruses are the most common cause of severe viral gastroenteritis in early childhood worldwide. Thus, the objectives of our study were to determine the molecular epidemiology and the clinical features of rotavirus gastroenteritis in Tunisia. Between January 2003 and April 2007, a prospective study was conducted on 788 stool samples collected from children under 12 years of age who were suffering from acute gastroenteritis. Rotavirus was detected by multiplex RT-PCR in 27% (n = 213) of samples, among them 79.3% (n = 169) cases were monoinfections. The frequency of rotavirus infections was significantly higher among inpatients (29%) than among outpatients (13%) (P < 0.001). The seasonal distribution of rotavirus diarrhea showed a winter peak, with an unusual peak from June to September. The mean duration of hospitalization was 6.5 ± 8.1 days and the mean age was 15.8 ± 22.8 months for rotavirus monoinfections. Fever, vomiting, abdominal pain, and dehydration were observed in 88, 98, 13, and 80 cases, respectively, in children with rotavirus monoinfections. G3P[8] (45.6%) and G1P[8] (23.9%) were the most common genotypes found in our study. The determination of rotavirus infection prevalence and the characterization of the rotavirus strains circulating will help us to better understand the molecular biology and epidemiology of the disease in our country.

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Murakami, Koichi, Tamie Noda, Daisuke Onozuka, and Nobuyuki Sera. "Salmonellain Liquid Eggs and Other Foods in Fukuoka Prefecture, Japan." International Journal of Microbiology 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/463095.

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The study aimed to evaluate the prevalence ofSalmonellain retail and wholesale foods in Fukuoka Prefecture, Japan. A total of 2,021 samples collected between 1999 and 2010 were tested using a culture method. Samples consisted of liquid eggs (n=30), meat (beef and pork) (n=781), offal (n=69), processed meats (n=2), seafood (n=232), processed seafood (dried fish) (n=76), vegetables (n=481), processed vegetables (n=87), fruits (n=167), and herbs (n=96) from 574 outlets and wholesale agents in 15 areas (five samples were undocumented regarding outlets). Overall, liquid egg showed significantly (P<0.001) higher frequencies ofSalmonellacontamination (13.3%) than beef (1/423, 0.2%) and pork (3/235, 1.3%).Salmonella entericasubsp.entericaserovar Enteritidis, the most common serovar as a human pathogen, were isolated from two liquid egg samples. NoSalmonellawere isolated from seafood and vegetable-related samples including seed sprouts (n=261). In conclusion, liquid egg is a significantSalmonellavehicle, showing a need to continue the vaccination of chickens to preventS.Enteritidis contamination in Japanese eggs. Moreover, further study is needed to evaluateSalmonellacontamination in seed sprouts with more sampling from retailers there.

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Hantono, Dedi, Yuanita F. D. Sidabutar, and Ully I. M. Hanafiah. "KAJIAN RUANG PUBLIK KOTA ANTARA AKTIVITAS DAN KETERBATASAN." LANGKAU BETANG: JURNAL ARSITEKTUR 5, no. 2 (December 27, 2018): 80. http://dx.doi.org/10.26418/lantang.v5i2.29387.

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Ruang esensinya adalah tempat manusia hidup dan beraktivitas. Namun tidak semua aktivitas dapat terakomodir karena setiap ruang dibatasi dengan fungsinya masing-masing. Bagi ruang pribadi keterbatasan ruang tersebut merupakan karakteristik utama bagi ruang itu sendiri sedangkan pada ruang publik yang memiliki berbagai macam aktivitas harus dapat menampung berbagai aktivitas di dalamnya. Untuk itulah perlu dilakukan kajian mengenai ruang publik terhadap permasalahan keterbatasan ruang yang sering ditemui. Tulisan ini menggunakan metode kualitatif dengan melakukan pendekatan kajian literatur. Ada beberapa literatur yang diambil dari beberapa ahli serta beberapa hasil penelitian dalam artikel jurnal untuk mendukung teori dan melihat kenyataan di lapangan. Pada akhir tulisan diambil suatu kesimpulan bahwa keterbatasan ruang publik terhadap berbagai macam aktivitas yang berlangsung di dalamnya dengan terbentuknya ruang bersama baik secara permanen maupun bergantian (waktu tertentu).Kata-kata Kunci: arsitektur, ruang publik, aktivitas, ruang bersamaURBAN PUBLIC SPACE STUDIES BETWEEN ACTIVITIES AND LIMITATIONSThe essence of space is a place where humans live and doing their activities. But not all activities can be accommodated because space is limited by their functions. For private space, space limitations are the main characteristics for space itself, while in public spaces that have various kinds of activities must be able to accommodate multiple activities in it. For this reason, a study of public space needs to be done on the problems of space limitations that are often encountered. This paper uses qualitative methods by conducting a literature review approach. There is some literature taken from several experts and several research results in the journal for support the theory and see the reality in the field. At the end of the writing, it was concluded that the limitations of the public space for various kinds of activities take place in it with the formation of shared spaces both permanently and alternately (certain times).Keywords: architecture, public space, activity, share spaceREFERENCESAgustapraja, H. R. (2018). Studi Pemetaan Perilaku (Behavioral Mapping) Pejalan Kaki Pada Pedesterian Alun-Alun Kota Lamongan. Civilla, 3(1), 134–139. https://doi.org/https://doi.org/10.30736/cvl.v3i1.220Athanassiou, E. (2017). The Hybrid Landscape Of Public Space In Thessaloniki In The Context Of Crisis. Landscape Research, 42(7), 782–794. https://doi.org/10.1080/01426397.2017.1372399Carr, J., & Dionisio, M. R. (2017). Flexible Spaces as a Third Way Forward for Planning Urban Shared Spaces. In Cities (pp. 73–82). Elsevier. https://doi.org/10.1016/j.cities.2017.06.009Carr, S., Francis, M., Rivlin, L. G., & Stone, A. M. (1992). Public Space. New York: Cambridge University Press.Farida, N. (2013). Effect of Outdoor Shared Spaces on Social Interraction in a Housing Estate in Algeria. Frontiers of Architectural Research, 2, 457–467. https://doi.org/10.1016/j.foar.2013.09.002Hakim, R., & Utomo, H. (2003). Komponen Perancangan Arsitektur Lansekap: Prinsip-Unsur dan Aplikasi Desain. Jakarta: Penerbit Bumi Aksara.Hanafiah, U. I. M., & Asharsinyo, D. F. (2017). Redefenisi Ruang Publik Pada Kampung Kreatif Pasundan. Studi Kasus: Koridor Tepian Sungai Cikapundung, RT 02 RW 04, Kelurahan Balonggede, Kecamatan Regol, Kota Bandung, Jawa Barat. Idealog, 2(2), 124–137. https://doi.org/10.25124/idealog.v2i2.1220Hantono, D. (2017). Pengaruh Ruang Publik Terhadap Kualitas Visual Jalan Kali Besar Jakarta. Arsitektura, 15(2), 532–540. https://doi.org/10.20961/arst.v15i2.15114Krier, R. (1979). Urban Space. New York: Rizzoli.Liem, Y., & Lake, R. C. (2018). Pemaknaan Ruang Terbuka Publik Taman Nostalgia Kota Kupang. Arteks, 2(2), 149–158. https://doi.org/10.30822/artk.v2i2.150Mulyandari, H. (2011). Pengantar Arsitektur Kota. (Oktaviani HS, Ed.) (1st ed.). Yogyakarta: Penerbit Andi.Murtini, T. W., & Wahyuningrum, S. H. (2017). Penggunaan Ruas Jalan Sebagai Pasar Tradisional Di Gang Baru Pecinan, Semarang. Modul, 17(1), 17–21. Retrieved from https://ejournal.undip.ac.id/index.php/modul/article/view/17246/12396Olesen, M., & Lassen, C. (2012). Restricted Mobilities: Access to, and Activities in, Public and Private Spaces. International Planning Studies, 17(3), 215–232. https://doi.org/10.1080/13563475.2012.704755Rapoport, A. (1990). The Meaning of the Built Environment: A Nonverbal Communication Approach (1st ed.). Arizona: University of Arizona Press.Rochimah, E., & Asriningpuri, H. (2018). Adaptasi Perilaku Pedagang Bazar Dalam Teritori Ruang Dagang. Nalars, 17(1), 21–28. https://doi.org/10.24853/nalars.17.1.21-28Salomon-Ayeh, B. E., King, R. S., & Decardi-Nelson, I. (2011). Street Vending and The Use of Urban Public Space in Kumasi, Ghana. Surveyor, 4(1), 20–31. Retrieved from http://dspace.knust.edu.gh/bitstream/123456789/3423/1/Surveyor Journal 3.pdfSantoso, J. T., Mustikawati, T., Suryasari, N., & Titisari, E. Y. (2016). Pola Aktivitas Wisata Belanja dI Kampung Wisata Keramik Dinoyo, Malang. Tesa Arsitektur, 14(1), 1. https://doi.org/10.24167/tes.v14i1.560Simpson, P. (2011). Street Performance And The City: Public Space, Sociality, And Intervening In The Everyday. Space and Culture, XX(X), 1–16. https://doi.org/10.1177/1206331211412270Sudarisman, I. (2017). Kajian Pedagang Kaki Lima Di Taman Tegalega, Bandung, Jawa Barat. Arsir , 1(2), 161–174. Retrieved from http://jurnal.um-palembang.ac.id/arsir/article/view/867/769

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Cubas, Santiago, Martín Varela, María N. Brito, Andrés Pouy, Nicolás D. Muniz, Camila Haro, Marysol Martínez, and César E. Canessa. "Tapp technique performed by young hands. Reproducing the results of the Lichtenstein procedure for symptomatic primary unilateral inguinal hernia." Revista Argentina de Cirugía 113, no. 4 (December 1, 2021): 434–43. http://dx.doi.org/10.25132/raac.v113.n4.1498.

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Santiago Cubas, 0000-0001-6026-5316; Martín Varela, 0000-0003-2376-2844; María N. Brito, 0000-0002-1394-3994; Andrés Pouy, 0000-0002-7136-144X; Nicolás D. Muniz, 0000-0002-6235-1303; Camila Haro, 0000-0003-4475-9740; Marysol Martínez, 0000-0001-8372-2006; César E. Canessa, 0000-0003-0446-7823.

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Tremlett, H. L., and J. Oger. "Ten years of adverse drug reaction reports for the multiple sclerosis immunomodulatory therapies: a Canadian perspective." Multiple Sclerosis Journal 14, no. 1 (January 2008): 94–105. http://dx.doi.org/10.1177/1352458507079658.

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Adverse drug reaction (ADR) reporting is essential in the post-marketing surveillance of drugs, detection of serious adverse reactions, and has been the basis for drug withdrawals. The study aimed to examine ADR reporting patterns to the multiple sclerosis (MS) immunomodulatory drugs (IMD) in Canada. All ADRs reported to the Canadian ADR Monitoring Program (CADRMP) from 1965 to March 2006 ( n = 193 208) were accessed and ADRs in which an IMD for MS (beta-interferon or glatiramer acetate) was the suspected drug extracted ( n = 888 reports were dated March/96—March/06). Almost half of all IMD ADRs reports (438/888) were sourced through the patient compared to 14.9% (10 649/71 373) of all ADRs reported to CADRMP over the same period. Of IMD ADR reports, 88.7% (788/888) were directed through the manufacturer compared to 57.7% (41197/71373) of all ADRs. Encouragement to others involved in patient care, such as pharmacists, nurses and physicians might enhance reporting of MS ADRs. Despite the limitations of ADR reporting data, previously unpublished case reports in several understudied MS populations were detailed: paediatrics (≤16 years old, n = 4), the elderly (≥65 years, n = 23) and during pregnancy ( n = 12). In addition, 46 deaths suspected by the reporter as being related to IMD treatment were detailed as well as three possible drug interactions. Multiple Sclerosis 2008; 14: 94—105. http://msj.sagepub.com

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Gafarov, V., E. Gromova, D. Panov, I. Gagulin, A. Gafarova, and V. Maximov. "Monoamine oxidase a gene polymorphism associated with hostility in male population of 45-64 in Russia/Siberia." European Psychiatry 64, S1 (April 2021): S439—S440. http://dx.doi.org/10.1192/j.eurpsy.2021.1173.

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IntroductionThe presence of low-activity alleles of the MAOA gene increases the risk of hostility.ObjectivesTo study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years.MethodsUnder the WHO International Program MONICA-psychosocial and HAPIEE a representative sample of men aged 45–64 years (n = 781 men, average age was 56.48 ± 0.2 years) examined in 2003-2005. All respondents independently completed a questionnaire on hostility. From the surveyed sample using the random number method 156 men were selected who were genotyped for MAOA-uVNTR polymorphism.ResultsIt was found the level of hostility in the population of men was 60.3%. In persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common - 50.9%. The results of building a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018).ConclusionsOur findings allow us to conclude that the low-active allele of the MAOA-L gene is associated with hostility.

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Gafarov, V. V., E. A. Gromova, D. O. Panov, I. V. Gagulin, V. N. Maksimov, and A. V. Gafarova. "Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE»)." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 1 (April 2, 2020): 39–44. http://dx.doi.org/10.31363/2313-7053-2020-1-39-44.

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Objective: to study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years old. Using the methods proposed by the WHO International Program “MONICA-psychosocial” and “HAPIEE”, a representative sample of men aged 45–64 years old (n = 781 men, average age was 56.48 ± 0.2 years) in 2003-2005. All respondents independently completed a questionnaire on hostility. From the surveyed sample, using the random number method, 156 men were selected who were genotyped for MAOA-uVNTR polymorphism. It was approved that the level of hostility in the population of men was 60.3%. It was revealed that among persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common — 50.9%. The results of building a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018). The results obtained allow us to conclude that the low-active allele of the MAOA-L gene is associated with hostility.

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Damaceno, Adalvane Nobres, Luciane Silva Ramos, and Teresinha Heck Weiller. "Perfil clínico epidemiológico de portadores de tuberculose em Santa Maria (2001 a 2012)." Espaço para a Saúde - Revista de Saúde Pública do Paraná 15, no. 4 (December 30, 2014): 34. http://dx.doi.org/10.22421/1517-7130.2014v15n4p34.

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INTRODUÇÃO: No Brasil a Tuberculose revela-se uma das principais causas de morbimortalidade, e está entre as doenças negligenciáveis. OBJETIVO: Descrever o perfil clínico e epidemiológico dos pacientes diagnosticados com Tuberculose no período de 2001 a 2012 do município de Santa Maria, Rio Grande do Sul. METODOLOGIA: Estudo transversal de abordagem descritiva, com dados secundários de todas as fichas de notificações do Sistema Nacional Agravos e de Notificação. RESULTADOS: Houve predomínio do sexo masculino (n= 1027 - 73,9%); faixa etária de 21 a 30 anos (n=348 - 25,1%); com 93,2% de casos novos (n=1294), solicitação do exame de sorologia para HIV para 91,4% (n = 1269) dos casos notificados, e cura de 78,2% (n= 1085) dos casos. CONCLUSÃO: Necessidade de reestruturação do Programa de Controle e Prevenção da Tuberculose, maiores esforços empreendidos na intensificação a prevenção, a vigilância epidemiológica e, principalmente, para organização da rede de atenção por meio da descentralização do atendimento para rede básica de saúde.

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Santolaya, María E., Ana M. Alvarez, Carmen L. Avilés, Ana Becker, José Cofré, Miguel A. Cumsille, Miguel L. O'Ryan, et al. "Early Hospital Discharge Followed by Outpatient Management Versus Continued Hospitalization of Children With Cancer, Fever, and Neutropenia at Low Risk for Invasive Bacterial Infection." Journal of Clinical Oncology 22, no. 18 (September 15, 2004): 3784–89. http://dx.doi.org/10.1200/jco.2004.01.078.

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Purpose To compare outcome and cost of ambulatory versus hospitalized management among febrile neutropenic children at low risk for invasive bacterial infection (IBI). Patients and Methods Children presenting with febrile neutropenia at six hospitals in Santiago, Chile, were categorized as high or low risk for IBI. Low-risk children were randomly assigned after 24 to 36 hours of hospitalization to receive ambulatory or hospitalized treatment and monitored until episode resolution. Outcome and cost were determined for each episode and compared between both groups using predefined definitions and questionnaires. Results A total of 161 (41%) of 390 febrile neutropenic episodes evaluated from June 2000 to February 2003 were classified as low risk, of which 149 were randomly assigned to ambulatory (n = 78) or hospital-based (n = 71) treatment. In both groups, mean age (ambulatory management, 55 months; hospital-based management, 66 months), sex, and type of cancer were similar. Outcome was favorable in 74 (95%) of 78 ambulatory-treated children and 67 (94%) of 71 hospital-treated children (P = NS). Mean cost of an episode was US $638 (95% CI, $572 to $703) and US $903 (95% CI, $781 to $1,025) for the ambulatory and hospital-based groups, respectively (P = .003). Conclusion For children with febrile neutropenia at low risk for IBI, ambulatory management is safe and significantly cost saving compared with standard hospitalized therapy.

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Esker, P. D., J. Harri, P. M. Dixon, and F. W. Nutter. "Comparison of Models for Forecasting of Stewart's Disease of Corn in Iowa." Plant Disease 90, no. 10 (October 2006): 1353–57. http://dx.doi.org/10.1094/pd-90-1353.

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Three forecasting models for Stewart's disease (Pantoea stewartii subsp. stewartii) of corn (Zea mays) were examined for their ability to accurately predict the prevalence of Stewart's disease in Iowa at the county level. The Stevens Model, which is used as a predictor of the early wilt phase of Stewart's disease, the Stevens-Boewe Model, which predicts the late leaf blight phase of Stewart's disease, and the Iowa State Model that is used to predict the prevalence of Stewart's disease, all use mean air temperatures for December, January, and February for a preplant prediction of Stewart's disease risk in a subsequent season. Models were fitted using weighted binary logistic regression with Stewart's disease prevalence data and air temperature data for 1972 to 2003. For each model, the years 1972 to 1999 (n = 786 county-years) were used for model development to obtain parameter coefficients. All three models indicated an increased likelihood for Stewart's disease occurring in growing seasons preceded by warmer winters. Using internal bootstrap validation, the Stevens Model had a maximum error between predicted and calibrated probabilities of 10%, whereas the Stevens-Boewe and Iowa State models had maximum errors of 1% or less. External validation for each model, using air temperature and seed corn inspection data between 2000 and 2003 (n = 154 county-years), indicated that overall accuracy to predict Stewart's disease at the county level was between 62 and 66%. However, both the Stevens and Stevens-Boewe models were overly optimistic in predicting that Stewart's disease would not occur within specific counties, as the sensitivity for these two models was quite low (18 and 43%, respectively). The Iowa State Model was substantially more sensitive (67%). The results of this study suggest that the Iowa State Model has increased predictive ability beyond statewide predictions for estimating the risk of Stewart's disease at the county level in Iowa.

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Slagman, Anna, Linton Harriss, Sandra Campbell, Reinhold Muller, and Robyn McDermott. "Folic acid deficiency declined substantially after introduction of the mandatory fortification programme in Queensland, Australia: a secondary health data analysis." Public Health Nutrition 22, no. 18 (September 4, 2019): 3426–34. http://dx.doi.org/10.1017/s1368980019002258.

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AbstractObjective:To investigate the prevalence of folic acid deficiency in Queensland-wide data of routine laboratory measurements, especially in high-risk sub-populations.Design:Secondary health data analysis.Setting:Analysis of routine folic acid tests conducted by Pathology Queensland (AUSLAB).Participants:Female and male persons aged 0–117 years with routine folic acid testing between 1 January 2004 and 31 December 2015. If repeat tests on the same person were conducted, only the initial test was analysed (n 291 908).Results:Overall the prevalence of folic acid deficiency declined from 7·5 % before (2004–2008) to 1·1 % after mandatory folic acid fortification (2010–2015; P < 0·001) reflecting a relative reduction of 85 %. Levels of erythrocyte folate increased significantly from a median (interquartile range) of 820 (580–1180) nmol/l in 2008 before fortification to 1020 (780–1350) nmol/l in 2010 (P < 0·001) after fortification. The prevalence of folic acid deficiency in the Indigenous population (14 792 samples) declined by 93 % (17·4 v. 1·3 %; P < 0·001); and by 84 % in non-Indigenous residents (7·0 v. 1·1 %; P < 0·001). In a logistic regression model the observed decrease of folic acid deficiency between 2008 and 2010 was found independent of gender, age and ethnicity (ORcrude = 0·20; 95 % CI 0·18, 0·23; P < 0·001; ORadjusted = 0·21; 95 % CI 0·18, 0·23; P < 0·001).Conclusions:While voluntary folic acid fortification, introduced in 1995, failed especially in high-risk subgroups, the 2009 mandatory folic acid fortification programme coincided with a substantial decrease of folic acid deficiency in the entire population.

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Diabaté, Abidina, Jean Louis Zerbo, and Frédéric Ouattara. "Variation of the foF2 parameter during fluctuating activity: Prediction with IRI-2012 compared to measured data from Ouagadougou inosonde station during solar cycles 21 and 22." VIETNAM JOURNAL OF EARTH SCIENCES 41, no. 1 (January 8, 2019): 59–68. http://dx.doi.org/10.15625/0866-7187/41/1/13549.

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In this paper, we review on diurnal variations of the foF2 ionospheric parameter predicted by the IRI-2012 model, and data from Ouagadougou ionosonde station located in the crest of the Equatorial Anomaly (Lat: 12.5°N; Long: 358.5°E, dip: 1.43°) during fluctuating geomagnetic activity conditions for the solar cycles 21 and 22. Our investigations are focused on the electrodynamic aspects, the influence of the ionospheric electric currents as well as the variations of the hourly values given by model and experimental measurements. A comparative study pointed out that the IRI-2012 model, through its URSI and CCIR subroutines, gives a good prediction of the critical frequency of the F2 layer between 0700 TL and 0000 TL. In addition, IRI -2012 tries to reproduce, as best as possible, the vertical drift E × B during minimum, decreasing phase, winter, and autumn. However, there is no effect of drift during the other seasons and solar cycle phases. A last, the model does not take into account the PRE phenomenon observed in autumn and the influence of the equatorial electrojet in this ionospheric zone.ReferencesAcharya R., Roy B., Sivaraman M.R., 2010. Dasgupta A. An empirical relation of daytime equatorial total electron content with equatorial electrojet in the Indian zone. J Atmos Terr Phys, 72(10), 774–780.Acharya R., Roy B., Sivaraman M.R.; Dasgupta A., 2011. On conformity of the EEJ based Ionospheric model to the Fountain effect and resulting improvements. J Atmos Terr Phys, 73, 779-784.Adeniyi J.O., Oladipo O.A., Radicella S.M., 2005. Variability of fof2 and comparison with iri model for an equatorial station. The Abdus Salam International Centre for Theoretical Physics, IC/2005/085, http://www.ictp.it/~pub_off.Adeniyi1 J.O., Oladjipo O.A., Radicella S.M., 2005. Variability of foF2 and comparison with IRI model for an equatorial station. The Abdus Salam International Centre for Theoretical Physics, IC/2005/085.Bilitza D., et al., 2014. The International Reference Ionosphere 2012-a model of international collaborationI. J. Space Weather Space Clim, 4, A07.Bilitza D., Reinisch B.W., 2008. International Reference Ionosphere 2007: Improvements and new parameters. Adv. Space Res, 42, 599–609.Farley D.T., Bonell E., Fejer B.G., Larsen M.F., 1986. The Prereversal Enhancement of the Zonal Electric Field in the Equatorial Ionosphere. J Geophys Res, 91(A12), 13,723–13,728.Faynot J.M., Villa P., 1979. F region at the magnetic equator. Ann Geophys, 35, 1–9.Fejer B.G., 1981. The equatorial ionospheric electric fields: A review. J Atmos Terr Phys, 43, 377.Fejer B.G., Farley D.T., Woodman R.F., Calderon C., 1979. Dependence of equatorial F region vertical drifts on season and solar cycle. J Geophys Res, 84, 5792.Legrand J.P., Simon P.A., 1989. Solar cycle and geomagnetic activity: A review for geophysicists. Part I. The contributions to geomagnetic activity of shock waves and of the solar wind. Ann. Geophys, 7, 565–578.Obrou K.O., 2008. Contribution à l’amélioration du modèle "International Reference Ionosphere" (IRI) pour l’ionosphère équatoriale. Thèse de doctorat Université de Cocody, Abidjan, Côte d’Ivoire.Ouattara F., 2009. Contribution à l’étude des relations entre les deux composantes du champ magnétique solaire et l’Ionosphère Equatoriale. Thèse de Doctorat d’Etat ès Sciences, Université Cheikh Anta Diop, Dakar, Sénégal.Ouattara F., 2013. IRI-2007 foF2 Predictions at Ouagadougou Station during Quiet Time Periods from 1985 to 1995. Archives of Physics Research, 4, 12–18.Ouattara F., Amory-Mazaudier C., 2009. Solar–geomagnetic activity and Aa indices toward a Standard. J. Atmos. Terr. Phys, 71, 1736–1748.Ouattra F., Nanéma, 2014. Quiet Time foF2 Variation at Ouagadougou Station and Comparison with TIEGCM and IRI-2012 Predictions for 1985 and 1990. Physical Science International Journal, 4(6), 892–902.Oyekola O.S., Fagundes P.R., 2012. Equatorial F2-layer variations: Comparison between F2 peak parameters at Ouagadougou with the IRI-2007 model. Earth, Planets Space, 64, 553–566.Rishbeth H., 1971. The F-layer dynamo. Planet, Space Sci, 19, 263.Vassal J.A., 1982. The variation of the magnetic field and its relationship with the equatorial electrojet in Senegal Oriental. Annals of Geophysics, Tome French, 38.Zerbo J.L., Amory-Mazaudier C. Ouattara F., Richardson J., 2012. Solar Wind and Geomagnetism, toward a Standard Classification 1868-2009. Ann Geophys, 30, 421–426. http://dx.doi.org/10.5194/angeo-30-421-2012.Zerbo J.L., Amory-Mazaudier C., Ouattara F., 2013. Geomagnetism during solar cycle 23: Characteristics. J. Adv. Res, 4(3), 265–274. Doi:10.1016/j.jare.2013.08.010.Zerbo J.L., Ouattara F., Zoundi C., Gyébré A., 2011. Solar cycle 23 and geomagnetic activity since 1868. Revue CAMES serie A, 12(2), 255–262.

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Arregui, L., R. Rathi, W. Zeng, A. Honaramooz, M. Gomendio, E. R. S. Roldan, and I. Dobrinski. "1 XENOGRAFTING OF ADULT MAMMALIAN TESTIS TISSUE." Reproduction, Fertility and Development 19, no. 1 (2007): 119. http://dx.doi.org/10.1071/rdv19n1ab1.

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Testis tissue grafting presents an option for preservation of genetic material when sperm recovery is not possible. Grafting of testis tissue from sexually immature males to immunodeficient mice results in germ cell differentiation and production of fertilization-competent sperm from different mammalian species (Honaramooz et al. 2002 Nature 418, 778–781). However, the efficiency of testis tissue xenografting from adult donors has not been critically evaluated. Spermatogenesis was arrested at meiosis in grafts from mature horses (Rathi et al. 2006 Reproduction 131, 1091–1098) and hamsters (Schlatt et al. 2002 Reproduction 124, 339–346), and no germ cell differentiation occurred in xenografts of adult human testis tissue (Schlatt et al. 2006 Hum. Reprod. 21, 384–389). The objective of this study was to investigate survival and germ cell differentiation of testis xenografts from sexually mature donors of different species. Small fragments of testis tissue from 10 donor animals of 5 species were grafted under the back skin of immunodeficient, castrated male mice (n = 37, 2–6/donor). Donors were pig (8 months old), goat (18 months old and 4 years old) (n = 2), bull (3 years old), donkey (13 months old), and rhesus monkey (3, 6, 11, and 12 years old). At the time of grafting, donor tissue contained elongated spermatids, albeit to different degrees (>75% of seminiferous tubules in testis tissue from pig, goat, bull, and 6–12-year-old monkeys, and 33 or 66% of tubules in tissue from donkey or 3-year-old monkey, respectively). Grafts were recovered <12 weeks (n = 14 mice), 12–24 weeks (n = 16 mice), and >24 weeks (n = 7 mice) after grafting and classified histologically as completely degenerated (no tubules found), degenerated tubules (only hyalinized seminiferous tubules observed), or according to the most advanced type of germ cell present. Grafts from pig, goat, bull, and 6–12-year-old monkeys contained >60% degenerated tubules or were completely degenerated at all time points analyzed. In contrast, in grafts from the 3-year-old monkey, only 18% of tubules were degenerated, 14% contained Sertoli cells only, 64% contained meiotic, and 4% haploid germ cells at 24 weeks after grafting. Similarly, donkey testis grafts recovered 12–24 weeks after grafting contained <2% degenerated tubules, 46% of tubules had Sertoli cells only, 45% contained meiotic, and 7% haploid germ cells. These results show that survival and differentiation of germ cells in testis grafts from sexually mature mammalian donors is poor. However, better graft survival and maintenance of spermatogenesis occurred in donor tissue from donkey and 3-year-old monkey that were less mature at the time of grafting. Therefore, species and age-related differences appear to exist with regard to germ cell survival and differentiation in xenografts from adult donors. This work was supported by USDA/CSREES 03-35203-13486, NIH/NCRR 5-R01-RR17359-05, the Spanish Ministry of Education, and Science (BES-2004-4112).

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Bauer, Christina, Dilek Sonntag, Anja Hildebrand, Gerhard Bühringer, and Ludwig Kraus. "Studiendesign und Methodik der Deutschen Suchthilfestatistik 2007." SUCHT 55, no. 7 (January 2009): 6–14. http://dx.doi.org/10.1024/2009.07.02.

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Ziel: Es werden Studiendesign, Stichprobenverfahren und Methoden der Datenerhebung der Deutschen Suchthilfestatistik 2007 beschrieben. Methodik: Die Stichproben bestehen aus ambulanten und stationären Einrichtungen der Suchthilfe, die mit dem 2007 neu eingeführten Deutschen Kerndatensatz (KDS) Daten zu Einrichtungs- und Patientenmerkmalen liefern. Ergebnisse: Für das Jahr 2007 wurden Daten von insgesamt 780 ambulanten Suchthilfeeinrichtungen sowie 171 stationären Suchthilfeeinrichtungen erfasst. Die ambulante Hauptauswertung umfasst 220.669 Patienten ambulanter Beratungsstellen sowie Institutsambulanzen (n=720; Erreichungsquote: 77 %). Die stationäre Auswertung bezieht sich auf 34.186 Patienten in stationären und teilstationären Rehabilitationseinrichtungen (n=147; Erreichungsquote: 60 %). Die Beteiligung an der Suchthilfestatistik 2007 war insgesamt etwas höher als im Vorjahr (ambulant 71 %, stationär 64 %). Mehr stationäre als ambulante Einrichtungen hatten ihre Daten bereits mit dem neuen KDS erhoben. Schlussfolgerungen: Die Umstellung der standardisierten Datensätze der Suchthilfestatistik ab 2007 führt noch zu deutlichen Übergangsproblemen, verbessert aber die Auswertung und Interpretation der Ergebnisse in Zukunft erheblich. Die hohe Erreichungsquote spricht insgesamt für eine gute Aussagekraft der Daten. Eine zentrale Herausforderung ist die Weiterentwicklung von Maßnahmen zur Sicherung der Repräsentativität und Datenqualität.

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Shrestha, Shilu, Subidha Tamrakar, and Ashok K. Banskota. "Outline of Hand and Wrist Injuries Presenting to an Emergency of a Tertiary Care Centre in Nepal." Journal of Nepal Health Research Council 17, no. 3 (November 13, 2019): 340–44. http://dx.doi.org/10.33314/jnhrc.v17i3.1806.

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Background: Hand and wrist injuries are getting commoner with increasing incidence of injuries and accidents. This study aims to identify the prevalence and pattern of hand and wrist injuries presenting to the emergency department of a tertiary care center of Nepal.Methods: The study was conducted through review of electronic data of the patient in the emergency department database for the period of 1 Nov 2005 till 31 Oct 2015.Data was extracted in Microsoft Excel 2007 andanalyzed to measure incidence and pattern of the hand and wrist injuries.Results: There were2899 number of patients with hand and wrist injuries during the period. Most were males (80%) and commonest age group was 20-29 years. Majority of the injuries were due to road traffic accident (n=786, 27.11%), fall injury (n=696, 24.09%), cut injury with sharps (n=404, 13.94%) and machinery injury (n=319, 11%). The commonest presenting injuries were hand fractures (n=1820, 62.8%) followed by distal radius fracture (n=613, 21.1%), crush injury of hand (n=409, 14.1%), and cut injury (n= 406, 14%). Almost half, 48.84 % cases were discharged from the emergency department with preliminary or definitive management.Conclusions: Hand and wrist injuries constitute a substantial number of casesseen and managed in the emergency department.Therefore, public health measures should be taken to reduce RTI, fall injury and occupational accidents. Andit is of paramount importance that emergency care giver attends these injuries properly and timely and establishes a good referral system as and when necessary.Keywords: Emergency; epidemiology; hand injury; Nepal; wrist injury

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Malyutina, Sofia, Vladimir Maximov, Olga Chervova, Pavel Orlov, Anastasiya Ivanova, Ekaterina Mazdorova, Andrew Ryabikov, Galina Simonova, and Mikhail Voevoda. "The Relationship between All-Cause Natural Mortality and Copy Number of Mitochondrial DNA in a 15-Year Follow-Up Study." International Journal of Molecular Sciences 24, no. 13 (June 21, 2023): 10469. http://dx.doi.org/10.3390/ijms241310469.

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We explored the relationship between the copy number of mitochondrial DNA (mtDNA-CN) and all-cause natural mortality. We examined a random population sample in 2003/2005 (n = 9360, men/women, 45–69, the HAPIEE project) and followed up for 15 years. Using a nested case–control design, we selected non-external deaths among those free from baseline cardiovascular diseases (CVD) and cancer (n = 371), and a sex- and age-stratified control (n = 785). The odds ratios (ORs) of death were 1.06 (95%CI 1.01–1.11) per one-decile decrease in mtDNA-CN independent of age, sex, metabolic factors, smoking, alcohol intake and education. The age–sex-adjusted ORs of death in the second and first tertiles of mtDNA-CN vs. the top tertile were 2.35 (95% CI 1.70–3.26) and 1.59 (1.16–2.17); an increased risk was confined to the second tertile after controlling for smoking and metabolic factors. The multivariable-adjusted OR of CVD death was 1.92 (95% CI 1.18–3.15) in tertile 2 vs. the top tertile of mtDNA-CN, and for cancer-related death the ORs were 3.66 (95% CI 2.21–6.05) and 2.29 (95% CI 1.43–3.68) in tertiles 2 and 1 vs. the top tertile. In the Siberian population cohort, the mtDNA-CN was an inverse predictor of the 15-year risk of natural mortality, due to the greatest impact of CVD and cancer-related death. The findings merit attention for exploring further the role of mtDNA in human ageing and the diversity of mortality.

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Knollman, Philip D., Christine H. Heubi, Jareen Meinzen-Derr, David F. Smith, Sally R. Shott, Susan Wiley, and Stacey L. Ishman. "Adherence to Guidelines for Screening Polysomnography in Children with Down Syndrome." Otolaryngology–Head and Neck Surgery 161, no. 1 (March 26, 2019): 157–63. http://dx.doi.org/10.1177/0194599819837243.

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Objectives To compare the percentage and mean age of children with Down syndrome (DS) who underwent polysomnography (PSG) to evaluate for obstructive sleep apnea (OSA) before and after the introduction of the American Academy of Pediatrics guidelines recommending universal screening by age 4 years. Study Design Retrospective cohort study. Setting Single tertiary pediatric hospital. Methods This study is a review of patients with DS seen in a subspecialty clinic. Children born preguidelines (2000-2006) were compared with children born postguidelines (2007-2012) regarding percentage receiving PSG, age at first PSG, and rate of OSA. Results We included 766 children with DS; 306 (40%) were born preguidelines. Overall, 61% (n = 467) underwent PSG, with a mean ± SD age of 4.2 ± 2.9 years at first PSG; 341 (44.5%) underwent first PSG by age 4 years. The rate of OSA (obstructive index ≥1 event/hour) among children undergoing first PSG was 78.2%. No difference was seen in the percentage receiving PSG preguidelines (63.4%) versus postguidelines (59.4%, P = .26). The mean age at the time of first PSG was 5.3 ± 3.5 years preguidelines versus 3.4 ± 2.0 years postguidelines ( P < .0001). Children in the postguidelines cohort were more likely to undergo first PSG during the ages of 1 through 4 years (67.4% vs 52.1%, P < .0001). There was no difference in rates of OSA between the pre- and postguidelines cohorts (79.8% vs 75.9%, P = .32). Conclusions Nearly two-thirds of children with DS (61%) underwent PSG overall, with a significant shift toward completion of PSG at an earlier age after the introduction of the American Academy of Pediatrics guidelines for universal screening for OSA.

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Han, Yinlu. "Erratum to: “The double differential cross section for n+U238 reaction” [Nucl. Phys. A 780 (2006) 34–51]." Nuclear Physics A 802, no. 1-4 (April 2008): 131. http://dx.doi.org/10.1016/j.nuclphysa.2008.01.018.

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