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1
Нікітін, Юрій. "РОЗВИТОК СІЛЬСЬКОГОСПОДАРСЬКОЇ ОСВІТИ НА УКРАЇНСЬКИХ ЗЕМЛЯХ У ДРУГІЙ ПОЛОВИНІ ХІХ – НА ПОЧАТКУ ХХ СТ.: ДИСКУСІЇ, ЗАКОНОДАВЧІ ІНІЦІАТИВИ, РЕЗУЛЬТАТИ". Уманська старовина, № 8 (30 грудня 2021): 5–25. http://dx.doi.org/10.31499/2519-2035.8.2021.249912.
Повний текст джерелаАнотація:
Ключові слова: Російська імперія, українські губернії, законодавство, органи місцевого самоврядування, різнопрофільні сільськогосподарські школи, чоловіча та жіноча освіта, виставки, з’їзди.
Анотація
На основі широкого кола історичних джерел з використанням методів історико-архівного аналізу, синтезу та аналізу висвітлено роль уряду, громадськості, органів місцевого самоврядування та меценатів у процесі формування мережі різнопрофільних сільськогосподарських закладів освіти в період модернізації українських губерній у межах Російської імперії в другій половині ХІХ – на початку ХХ ст.
Аналіз історіографічної спадщини засвідчує, що наявні праці не в повній мірі розкривають основні аспекти обраної для дослідження проблеми. За результатами проведеного дослідження з’ясовано, які основні чинники впливали на темпи формування мережі сільськогосподарських освітніх закладів для чоловіків та жінок, еволюцію законодавчої бази з даного питання, оцінки громадськості щодо якості та значення знань з підвищення продуктивності тогочасного сільськогосподарського виробництва. Показано роль з’їздів та виставок у поширенні досягнень аграрної сфери серед виробників сільськогосподарської продукції. Приділено увагу маловідомим аспектам обраної теми, які потребують подальшої наукової розробки.
Посилання
Beketov, 1898 – Beketov V.A. Nizshie selskohozyaystvennyie shkolyi i potrebnosti krestyanskogo chastnovladelcheskogo hozyaystva [Lower agricultural schools and the needs of a private peasant economy]. Vornezh, 1898. 120 s. [in Russian]
Bessmertnaya, 2015 – Bessmertnaya L.A. Uchebno-vospitatelnaya rabota v nizshih zhenskih selskohozyaystvennyih shkolah Rossii kontsa ХІХ – nachala ХХ veka [Teaching and educational work in the lower women's agricultural schools in Russia at the end of the ХІХ – beginning of the ХХ century] // Uchenyie zapiski. Elektronnyiy nauchnyiy zhurnal Kurskogo gosudarstvennogo universiteta, 2015. № 1 (33). URL: http://scientific-notes.ru/#new-number?id=38 [in Russian]
Volos, 2003 – Volos O.V. Silskohospodarska prosvitnytska diialnist zemstv Khersonshchyny (kinets ХІХ – pochatok ХХ st.) [Silskogospodarska Educational Activity of the Zemstvos of Kherson Oblast (3rd century - ХІХ century - ear of the ХХ century)] // Derzhavna etnonatsionalna polityka: pravovyi ta kulturolohichnyi aspekty v umovakh Pivdnia Ukrainy: zbirnyk naukovykh prats V Vseukrainskoi naukovo-praktychnoi konferentsii, Zaporizhzhia, 2 – 3 zhovtnia 2003 r. Simferopol, 2003. S. 155-158. [in Ukrainian]
Voron, 2015 – Voron V.P. Razvitie vneshkolnogo selskohozyaystvennogo prosvescheniya na territorii Ukrainyi vo vtoroy polovine ХІХ – nachale ХХ st. [Development of out-of-school agricultural education on the territory of Ukraine in the second half of the ХІХ - early ХХ century] Izvestiya Gomelskogo gosudarstvennogo universiteta imeni F. Skorinyi, 2015. № 4. URL: https://vesti.gsu.by/2015/vesti_gsu_2015_4.pdf [in Russian]
Geyduk, 1891 – Geyduk F.I. Nashi nizshie selsko-hozyaystvennyie shkolyi [Our lower agricultural schools]. Odessa, 1891. 88 s. [in Russian]
Esikova, 2010 – Esikova M. Selskohozyaystvennoe obrazovanie v Rossii (vtoraya polovina ХІХ v. – 1917 g.) [Agricultural education in Russia (second half of the ХІХ century - 1917)] // Vlast. № 7. S. 150-154. [in Russian]
Zemskiy sbornik, 1902 a – Zemskiy sbornik Chernigovskoy gubernii. Dekabr. № 12 [Zemsky collection of the Chernigov province. December. № 12]. Chernigov: Tip. Gubernskogo zemstva, 1902. 256 s. [in Russian]
Zemskiy sbornik, 1902 b – Zemskiy sbornik Chernigovskoy gubernii. Oktyabr. № 10 [Zemsky collection of the Chernigov province. October. № 10]. Chernigov: Tip. Gubernskogo zemstva, 1902. 256 s. [in Russian]
Kovalenko, 2014 – Kovalenko N.P. Silskohospodarski zꞌizdy ta yikhnia rol u poshyrenni znan pro sivozminy v zemlerobstvi Ukrainy (druha polovyna XIX – pochatok XX stolittia) [Silskogospodarskі zꞌїzdi and їхnya role in the expanded knowledge about the present in the farming of Ukraine (the other half of the ХІХ is the ear of the XX century)]. Zbirnyk naukovykh prats Kyivskoho natsionalnoho universytetu im. T.Shevchenka. Kyiv, 2014. Vyp. 42: Etnichna istoriia narodiv Yevropy. S. 106-112. [in Ukrainian]
Kostiuk, 2005 – Kostiuk M.V. Z istorii stanovlennia nyzhchoi silskohospodarskoi osvity na Cherkashchyni [From the history of the formation of the lower social and cultural education in Cherkasy] // Chasopys ukrainskoi istorii. K., 2005. Vyp. 2. S. 32-35. [in Ukrainian]
Makarets, 2010 – Makarets S.V. Tekhnolohiia vyroshchuvannia zernovykh kultur u kozatsko-selianskykh hospodarstva Poltavshchyny na rubezhi XIX – XX st. [Makarets The technology of grain crops viroshuvannya at the Cossack-rural government of the Poltava region at the turn of the XIX – XX centuries] // Naukovi pratsi istorychnoho fakultetu natsionalnoho universytetu. 2010. Vyp. 28. S. 98-101. [in Ukrainian]
Moskalskiy, 1881 – Moskalskiy N. Selskohozyaystvennyie uchebnyie zavedeniya vedomstva Ministerstva gosudarstvennyih imuschestv [Agricultural educational institutions of the Ministry of State Property]. // Srednie selskohozyaystvennyie zavedeniya. SPb., 1881. Vyip. II. 88 s. [in Russian]
Moskalskiy, 1893 – Moskalskiy N.P. Selskohozyaystvennoe obrazovanie [Agricultural education] // Selskoe i lesnoe hazyaystvo Rossii. SPb., 1893. S. 363-390 [in Russian]
Nebolskiy, 1884 – Nebolskiy A.G. Istoriko-statisticheskiy ocherk obschego i spetsialnogo obrazovaniya v Rossii [Historical and statistical sketch of general and special education in Russia]. – SPb., 1884. 257 s. [in Russian]
Nyzhnyk, 2019 – Nyzhnyk S. Umanske uchylyshche sadivnytstva i zemlerobstva v istorii vitchyznianoi osvity: do 175-richchia zasnuvannia umanskoho natsionalnoho universytetu sadivnytstva [Umansk school of gardening and farming in the history of modern education: until the 175th day of falling asleep at the Uman national university of gardening] // Umanska starovyna. Uman, 2019. Vyp. 6. URL: http://usj.udpu.edu.ua/article/view/186719 [in Ukrainian]
Normalnoe Polozhenie, 1883 – Normalnoe Polozhenie o nizshih selskohozyaystvennyih shkolah. Vyisochayshe utverzhdennoe 27 dekabrya 1883 g. [Normal Statute for Lower Agricultural Schools. Highest approved on December 27, 1883] // PSZRI. Sobranie trete. T. 3. 1883. SPb., 1886. 1018 s. [in Russian]
O dopuschenii lits, 1913 – O dopuschenii lits zhenskogo pola k sluzhbe po uchebno-vospitatelnoy chasti v selskohozyaystvennyih uchebnyih zavedeniyah. Vyisochayshe utverzhdennyiy odobrennyiy Gosudarstvennyim sovetom i Gosudarstvennoy dumoy zakon 30 iyunya 1913 g. [On the admission of females to the educational service in agricultural educational institutions. The highest approved law approved by the State Council and the State Duma on June 30, 1913] // PSZRI. Sobranie trete. T. 33. Ch.1. SPb., 1913. 1561 s. [in Russian]
Obzor, 1898 – Obzor deyatelnosti Ministerstva Zemledeliya i Gosudarstvennyih Imuschestv za 4-y god ego suschestvovaniya (30 marta 1897g. – 30 marta 1898 g.) [Review of the activities of the Ministry of Agriculture and State Property for the 4th year of its existence (March 30, 1897 - March 30, 1898)]. SPb., 1898. 300 s. [in Russian]
Polozhenie, 1895 – Polozhenie o selskohozyaystvennoy i promyishlennoy vyistavke, ustraivaemoy Kievskim obschestvom selskogo hozyaystva i selskohozyaystvennoy promyishlennosti v Kieve v 1898 [Regulations on the agricultural and industrial exhibition organized by the Kiev Society of Agriculture and Agricultural Industry in Kiev in 1898]. g. Kiev, 1895. 8 s. [in Russian]
Polozhenie, 1900 – Polozhenie o selskohozyaystvennyih remeslennyih uchebnyih masterskih. Vyisochayshe utverzhdennoe 10 marta 1897 g. [Regulation on agricultural craft training workshops. Highest approved on March 10, 1897] // PSZRI. Sobranie trete. T. XVII. 1897. SPb., 1900. 1562 s. [in Russian]
Polozhenie, 1904 – Polozhenie o selskohozyaystvennom obrazovanii. Vyisochayshe utverzhdennoe 26 maya 1904 goda [Regulation on agricultural education. Highest approved on May 26, 1904]. // PSZRI. Sobranie trete. T. XXIV, 1904. SPb., 1907. 1257 s. [in Russian]
Pravila, 1898 – Pravila dlya uchenits i slushatelnits Zozulinskoy zhenskoy prakticheskoy shkolyi [Rules for pupils and students of the Zozulinskaya women's practical school] // Sbornik svedeniy po selskohozyaystvennomu obrazovaniyu. Vyip. 1. Zhenskoe obrazovanie. SPb., 1898. S. 179-188. [in Russian]
Sbornik, 1900 – Sbornik svedeniy po selskohozyaystvennomu obrazovaniyu [Collection of information on agricultural education]. Vyip. IV. Selskohozyaystvennyie uchebnyie zavedeniya po svedeniyam k 1 yanvarya 1898 goda. SPb., 1900. 195 s. [in Russian]
Sbornik, 1910 – Sbornik svedeniy po selskohozyaystvennomu obrazovaniyu [Collection of information on agricultural education]. Selskohozyaystvennyie uchebnyie zavedeniya v 1910 godu. SPb. Vyip. XVI, 1910. 188 s. [in Russian]
Sorokina, 2019 – Sorokina T.A. Stanovlenie seti nizshih selskohozyaystvennyih shkol v Kurskoy gubernii v kontse ХІХ – nachale ХХ veka [Formation of a network of lower agricultural schools in the Kursk province in the late ХІХ - early ХХ centuries] // Uchenyie zapiski. Elektronnyiy nauchnyiy zhurnal Kurskogo gosudarstvennogo universiteta, 2019. № 2 (50). T. 1. URL: https://cyberleninka.ru/article/n/stanovlenie-seti-nizshihselskohozyaystvennyh-shkol-v-kurskoy-gubernii-v-kontse-xix-nachale-xx-veka/viewer [in Russian]
Terletska, 2013 – Terletska U.I. Poshyrennia silskohospodarskykh znan za dopomohoiu chytan i besid u Chernihivskii hubernii naprykintsi ХІХ – na pochatku ХХ stolittia [Expansion of the Silk-dweller's knowledge for additional reading and conversation in the Chernigiv province for example in the XIX - on the ear of the XX century] // Visnyk Chernihivskoho natsionalnoho pedahohichnoho universytetu, 2013. Vyp. 110. Pedahohichni nauky. S. 102-104. [in Ukrainian]
Tretyakov, 2017 – Tretyakov A.V. Obrazovatelnoe selskohozyaystvennoe zakonodatelstvo poreformennoy Rossii – rezultat reform 60 – 70-h godov ХІХ v. [The educational agricultural legislation of post-reform Russia is the result of the reforms of the 60s - 70s of the ХІХ century] // Bereginya. 777. Sova: obschestvo, politika, ekonomika. № 4 (35). S. 18-26. [in Russian]
Trudyi, 1879 – Trudyi komissii po sostavleniyu proekta (Polozheniya o Nizshih selskohozyaystvennyih shkolah) [Proceedings of the Drafting Commission (Provisions on Lower Agricultural Schools]. SPb, 1879. 160 s. [in Russian]
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Sheehan, Warren J., Mark A. Williams, Zoe Paskins, Matthew L. Costa, Miguel Antonio Fernandez, Jenny Gould, Philip Bell, et al. "Research priorities for the management of broken bones of the upper limb in people over 50: a UK priority setting partnership with the James Lind Alliance." BMJ Open 9, no. 12 (December 2019): e030028. http://dx.doi.org/10.1136/bmjopen-2019-030028.
Повний текст джерелаАнотація:
ObjectiveTo determine research priorities for the management of broken bones of the upper limb in people over 50, which represent the shared priorities of patients, their families, carers and healthcare professionals.Design/settingA national (UK) research priority setting partnership.ParticipantsPeople aged 50 and over who have experienced a fracture of the upper limb, carers involved in their care, family and friends of patients, healthcare professionals involved in the treatment of these patients.MethodsUsing a multiphase methodology in partnership with the James Lind Alliance over 15 months (September 2017 to December 2018), a national scoping survey asked respondents to submit their research uncertainties. These were amalgamated into a smaller number of research questions. The existing evidence was searched to ensure that the questions had not already been answered. A second national survey asked respondents to prioritise the research questions. A final shortlist of 25 questions was taken to a multi-stakeholder workshop where a consensus was reached on the top 10 priorities.ResultsThere were 1898 original uncertainties submitted by 328 respondents to the first survey. These original uncertainties were refined into 51 research questions of which 50 were judged to be true uncertainties following a review of the research evidence. There were 209 respondents to the second (interim prioritisation) survey. The top 10 priorities encompass a broad range of uncertainties in management and rehabilitation of upper limb fractures.ConclusionsThe top 10 UK research priorities highlight uncertainties in how we assess outcomes, provide information, achieve pain control, rationalise surgical intervention, optimise rehabilitation and provide psychological support. The breadth of these research areas highlights the value of this methodology. This work should help to steer research in this area for the next 5–10 years and the challenge for researchers now is to refine and deliver answers to these research priorities.
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Sójka-Zielińska, Katarzyna. "Stulecie Kodeksu cywilnego szwajcarskiego." Czasopismo Prawno-Historyczne 64, no. 2 (October 31, 2018): 27–59. http://dx.doi.org/10.14746/cph.2012.64.2.02.
Повний текст джерелаАнотація:
The Swiss Civil Code (Schweizerisches Zivilgesetzbuch – ZGB) came into being on 1 January 1912 culminating the series of so called great civil codifications of continental Europe. The vast experience in the codification work within the Roman legal culture allowed the editors of the ZGB, and its author, Eugen Huber in particular, to create a truly original work that perfectly combined long legal traditions of individual Swiss cantons with the requirements of contemporary expectations, the ideas of individualism with those of social solidarity, the liberal slogans with the policy of interventionism, and the letter of law with the principles of equity and the canons of ethics. The staring point for the Swiss Civil Code was a draft authored by W. Munziger, which referred to the Zurich Code Civil, the German commercial code, the Austrian ABGB of 1861 and the Dresdener law of obligations of 1866. Another important stage was the initiative of the Swiss Juristenverein which in 1884 proposed a comparative study of all cantonal private law systems. The results of that study were to serve as a basis for the future nationwide unification of the legal system. Between 1893 and 1898 Eugen Huber developed three preliminary drafts, covering family law, succession law and rights in property. In 1900 they were published as a government project and put forward for a public discussion carried out by a 31-member expert group, with wide participation of individual citizens and interest groups. Eventually, on 10 December, the project was unanimously adopted as Schweizerisches Zivilgesetzbuch, Codice civile svizzero (ZGB) to come into force and be binding as of 1 January 1912. Among the many states drat drew on the Swiss Civil Code when drafting their own codes were Lichtenstein, Austria, Hungary, Greece, Italy and Turkey. In the latter, the ZGB was adopted as part of the reforms under Kamal Atatürk. The Swiss codification was highly valued by the civil lawyers in the Second Polish Republic.
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Kurygin, A. A., and V. V. Semenov. "Academician Vladimir Mikhailovich Mysh (1873–1947) (on the 150th anniversary of his birth)." Grekov's Bulletin of Surgery 182, no. 1 (October 25, 2023): 7–10. http://dx.doi.org/10.24884/0042-4625-2023-182-1-7-10.
Повний текст джерелаАнотація:
An outstanding surgeon, scientist, teacher and organizer of healthcare, academician of the USSR Academy of Medical Sciences (1945), Honored Scientist of the RSFSR (1934), founder of the largest surgical school in Siberia, Professor Vladimir Mikhailovich Mysh was born on January 4 (16), 1873 in St. Petersburg in the family of a lawyer. He received his secondary education in a classical gymnasium and entered the Imperial Military Medical Academy, which he graduated in 1895 with honors and was left for three years to improve at the Department of Surgery under the guidance of Professor N. A. Velyaminov. In 1898, V. M. Mysh defended his doctoral dissertation on the topic: «Herniae vaginales ingvinales in childhood» and was assigned to Kaluga, where he worked as the head of the Surgical Department in a Military hospital. In 1901, he was elected by competition to the position of professor of the Department of General Surgery with Desmurgy and the study of dislocations and fractures at the Medical Faculty of Tomsk University. In 1909, V. M. Mysh became the head of the Department of Faculty Surgery of Tomsk University, which he headed until 1931, and in 1922, he concurrently headed the Department of Urology created by him. He was the first in Russia and the third in the world to perform radical surgery for alveolar echinococcosis of the liver. In 1931, Vladimir Mikhailovich together with the staff of Tomsk State Medical University moved to Novosibirsk, where he continued to head the Department of Surgery, and in 1935, took an active part in the opening of Novosibirsk Medical Institute and the creation of the Department of Faculty Surgery in it. V. M. Mysh initiated the introduction of specialized urological care in Siberia and made a very great contribution to the development of neurosurgery. Academician V. M. Mysh created the largest surgical school in Siberia, from which famous professors came out: V. S. Levit, G. M. Mukhadze, M. S. Rabinovich, S. L. Schneider, B. I. Fuchs, K. N. Cherepnin, A. G. Savinykh, V. M. Galkin. Vladimir Mikhailovich was the author and co-author of 136 scientific papers, including 11 monographs and manuals on abdominal and thoracic surgery, oncology, urology, neurosurgery, diseases of bones and joints, general and plastic surgery. He was awarded two Orders of Lenin, the Order of the Red Banner of Labor, medals «For Valiant Labor in the Great Patriotic War of 1941–1945», «For Labor Valor». Academician V. M. Mysh died on December 31, 1947 and was buried at the Zaeltsovsky Cemetery in Novosibirsk. The surgical clinic of the State Institute for Advanced Training of Doctors and the Department of Faculty Surgery of NSMU were named after V. M. Mysh. He was listed in the gallery of Honorary Professors of the Novosibirsk State Medical Academy.
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Guevara-Murua, A., C. A. Williams, E. J. Hendy, A. C. Rust, and K. V. Cashman. "Observations of a stratospheric aerosol veil from a tropical volcanic eruption in December 1808: is this the "Unknown" ~1809 eruption?" Climate of the Past Discussions 10, no. 2 (April 28, 2014): 1901–32. http://dx.doi.org/10.5194/cpd-10-1901-2014.
Повний текст джерелаАнотація:
Abstract. The "Unknown" eruption of 1808/1809 was the second most explosive SO2-rich volcanic eruption in the last two centuries, only eclipsed by the cataclysmic VEI 7 Tambora eruption in April 1815. However, no eyewitness accounts of the event, and therefore its location, or the atmospheric optical effects associated with its aerosols have been documented from historical records. Here we report on two meteorological observations dating from the end of 1808 that describe phenomena we attribute to volcanic-induced atmospheric effects caused by the Unknown eruption. The observations were made by two highly respected Latin American scientists. The first, Francisco José de Caldas, describes a stratospheric aerosol haze, a "transparent cloud that obstructs the sun's brilliance", that was visible over the city of Bogotá, Colombia, from 11 December 1808 to at least mid-February 1809. The second, made by physician José Hipólito Unanue in Lima, Peru, describes sunset after-glows (akin to well-documented examples known to be caused by stratospheric volcanic aerosols) from mid-December 1808 to February 1809. These two accounts provide direct evidence of a persistent stratospheric aerosol veil that spanned at least 2600 km into both Northern and Southern Hemispheres and establish that the source was a tropical volcano. Moreover, these observations confirm that the Unknown eruption, previously identified and tentatively assigned to February 1809 (±4 months) from analysis of ice core sulphate records, occurred in late November or early December 1808 (4 December 1808 ± 7 days). This date has important implications for the associated hemispheric climate impacts and temporal pattern of aerosol dispersal.
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Guevara-Murua, A., C. A. Williams, E. J. Hendy, A. C. Rust, and K. V. Cashman. "Observations of a stratospheric aerosol <i>veil</i> from a tropical volcanic eruption in December 1808: is this the <i>Unknown</i> ∼1809 eruption?" Climate of the Past 10, no. 5 (September 16, 2014): 1707–22. http://dx.doi.org/10.5194/cp-10-1707-2014.
Повний текст джерелаАнотація:
Abstract. The Unknown eruption of 1808/1809 was the second most explosive SO2-rich volcanic eruption in the last two centuries, eclipsed only by the cataclysmic VEI 7 Tambora eruption in April 1815. However, no eyewitness accounts of the event, and therefore its location, or the atmospheric optical effects associated with its aerosols have been documented from historical records. Here we report on two meteorological observations dating from the end of 1808 that describe phenomena we attribute to volcanic-induced atmospheric effects caused by the Unknown eruption. The observations were made by two highly respected Latin American scientists. The first, Francisco José de Caldas, describes a stratospheric aerosol haze, a "transparent cloud that obstructs the sun's brilliance", that was visible over the city of Bogotá, Colombia, from 11 December 1808 to at least mid-February 1809. The second, made by physician José Hipólito Unanue in Lima, Peru, describes sunset after-glows (akin to well-documented examples known to be caused by stratospheric volcanic aerosols) from mid-December 1808 to February 1809. These two accounts provide direct evidence of a persistent stratospheric aerosol veil that spanned at least 2600 km into both Northern and Southern Hemispheres and establish that the source was a tropical volcano. Moreover, these observations confirm that the Unknown eruption, previously identified and tentatively assigned to February 1809 (±4 months) from analysis of ice core sulfate records, occurred in late November or early December 1808 (4 December 1808 ±7 days). This date has important implications for the associated hemispheric climate impacts and temporal pattern of aerosol dispersal.
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Massen, V. N. "OBSTETRIC GYNECOLOGICAL SOCIETY IN BERLIN Meeting December 11, 1891." Journal of obstetrics and women's diseases 6, no. 4 (August 27, 2020): 402–9. http://dx.doi.org/10.17816/jowd64402-409.
Повний текст джерелаАнотація:
Brse demonstrated a new vaginal electrode that he made for such electrical applications where one wishes to take advantage of the pole-to-pole current. The electrode consists of a clay cylinder with a circumference of 9 cm, which is inserted into the vagina in exactly the same way as a tubular mirror. In this clay cylinder is placed a metal cylinder, equipped with numerous holes, which has a screw at its outer end to strengthen the conductor. After the introduction of the clay cylinder, a metal cylinder is inserted into the vagina, and the clay tube is filled with warm water. The wet clay cylinder is an excellent conductor of current and replaces the skin electrode made from a sponge. If this cylinder is inserted into the vagina for a length of 8-10 cm, then with a circumference of 9 cm, it will correspond to a flat electrode of 72-90 sq. Cm. This electrode is intended for use where one wants to concentrate the current density in more than one place of the vagina. but evenly distribute the current over the pelvic organs. It is used more where, when using strong galvanic currents, they want to avoid the cauterizing effect on the vaginal mucosa, which easily occurs when spherical electrodes are used, despite being wrapped in cotton wool. Finally, it is used where one wants to obtain an interpolar (so-called catalytic) effect. The patient, when using this electrode, tolerates perfectly well currents of 80-100 MA, while cauterization of the vaginal mucosa is not obtained.
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Teich, Mikuláš. "Dorothy Mary Moyle Needham. 22 September 1896 – 22 December 1987." Biographical Memoirs of Fellows of the Royal Society 49 (January 2003): 351–65. http://dx.doi.org/10.1098/rsbm.2003.0020.
Повний текст джерелаАнотація:
In July 1994 I was approached by The Royal Society asking whether I would be willing to help in putting together a biographical memoir for Dr Dorothy Moyle Needham, who died in December 1987. For a variety of reasons, the Fellow of The Royal Society who originally undertook to write the memoir had been unable to deliver it before his death. After responding that I would be happy to assist, I was informed that I would, no doubt, be contacted by the writer who undertook to complete the task. As it turned out, I heard nothing more and, while occasionally wondering at the unusual delay in the publication of the memoir, I left it at that. That is, until in the spring of 2000 when I noticed that there was still no memoir on ‘Dophi’, as she was known to friends and colleagues. I found this very strange in view of the fact that almost 111/2 years had elapsed since her death and that she was among the first 10 elected female Fellows of The Royal Society. After some hesitation, I wrote on 7 May 2000 to The Lord Lewis of Newnham FRS (then Warden of Robinson College, Cambridge), alerting him to the situation. He was more than surprised and, following his enquiries, in July 2000 I became the third author invited to prepare Dr D.M. Needhams biographical memoir. As in private duty bound, I accepted the invitation, although not without anxiety over predicaments perceived beforehand. For one thing, though I had been collaborating with Dorothy Needham since 1972, the subject was history of biochemistry. Usually a biographical memoir is prepared by a person acquainted at first hand with the experimental/theoretical features of the work of the deceased Fellow. For another thing, I realized that I would be able to work on the memoir only intermittently because of other commitments, including prolonged stays abroad. All this has something to do with the delay in preparing this memoir, including the format.
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Akhmetshin, Ruslan B. "Anton Chekhov’s “The Philistines” in terms of literature studies." RUDN Journal of Studies in Literature and Journalism 28, no. 3 (December 15, 2023): 451–61. http://dx.doi.org/10.22363/2312-9220-2023-28-3-451-461.
Повний текст джерелаАнотація:
The goal of the study is to clarify the chronological framework of the so called Sakhalin period of Chekhov’s biography. The analysis of the creation of “The Teacher of Literature” is conducted to achieve it. The fate of the story “The Teacher of Literature” appears to be somewhat confused: the writer adds together “The Philistines” (“Novoe Vremja”, November 28, 1889) and “The Teacher of Literature” (“Russkie Vedomosti”, July 10, 1894). Chekhov used to avoid reiteration in his publications; thus, he dismissed the first title, and the story first appeared in the collection “Novellas and Stories” (the beginning of December, 1894) under the title “The Teacher of Literature”. As if following the writer’s will “The Philistines” was not included into volume 7 of the Completed Works of Chekhov (1974-1982) thus creating the gap effect. Having rejected the dramatic ending of “The Philistines”, Chekhov seemed to have restored it later when writing “The Teacher of Literature”, which originally constituted the second chapter of the modern story. Taking into consideration the ending of “The Philistines” postponed for five years, the story itself can be regarded as a fact of the writer’s biography against the background of the epistolary evidence and can reveal the writer’s mood before his trip to Sakhalin Island. Thus, the speculations over the story’s ideas can be related to the issue concerning the genre of the book “Sakhalin Island”.
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Porter, R., S. L. Gillespie, M. Song, G. Ball, A. Crawford, A. Churchhouse, M. Gardner, et al. "P127 Inflammatory Bowel Disease-associated colorectal cancers: retrospective cohort study from a tertiary centre surveillance programme over 10 years." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i293. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0257.
Повний текст джерелаАнотація:
Abstract Background Patients with IBD have increased risk for developing colorectal cancer (CRC), with poorer survival, compared to those without IBD. Despite surveillance colonoscopy, IBD post-colonoscopy CRC (PCCRC) rates are unacceptably high at 28-45%. We define surveillance colonoscopy quality, IBD-dysplasia and IBD-CRC prevalence, IBD-CRC characteristics, and IBD PCCRC rates at a tertiary IBD centre. Methods The GI Reporting Tool (Unisoft Medical Systems) was searched for IBD surveillance colonoscopy reports from April 2008–December 2018. Electronic medical records were reviewed. IBD phenotype and diagnosis date was confirmed on the Lothian IBD Registry. Follow-up was until September 2022. Results 1892 colonoscopies from 1262 patients were included. Median follow-up was 7.1 (4.4, 9.5) years. 885/1262 (70.1%) had UC, 344/1262 (27.3%) had Crohn’s, and 33/1262 (2.6%) had IBD-U. Median disease duration at colonoscopy was 16.8 (11, 24.6) years. 1825/1892 (96.5%) colonoscopies achieved caecal intubation, 1735/1840 (94.3%) adhered to biopsy guidelines and 704/1892 (37%) used chromoendoscopy. Histological inflammation was identified in 873/1823 (47.9%) cases; 57.2% in the right colon. Bowel preparation was poor in 194/1892 (10.3%) procedures and the most documented reason for not performing chromoendoscopy. Poor bowel preparation was associated with 23/60 (38.3%) poorly tolerated and 29/52 (55.8%) incomplete colonoscopies. Moviprep was superior to Picolax (p<0.001). GI physicians were more likely to use chromoendoscopy (p<0.001), biopsy per guideline (p<0.001), and identify dysplasia (p=0.012) compared to surgical colleagues. Dysplasia was identified in 145/1892 (7.7%) colonoscopies: 84/1892 (4.4%) sporadic, 22/1892 (1.2%) IBD-associated, and 39/1892 (2.1%) unspecified. IBD-CRC is rare, at 0.8 cases per 1000 patient years. Within the study period, 20/1262 (1.6%) patients had CRC diagnosed. 17/20 (85%) had UC and 3/20 (15%) had Crohn’s. 15/17 (88%) UC patients had E3 disease. 11/20 (55%) presented with lymph node or distant metastasis. 8/20 (40%) tumours had mucinous differentiation; only 1/15 (6.7%) was well differentiated. IBD-CRC patients had longer disease duration (28.3 (19.7, 37.8) years) compared to patients without CRC (22.25 (16.42, 29.85) years) at follow-up (p=0.028). The 3-year PCCRC rate was 15%. Conclusion IBD-CRC is rare however IBD PCCRC rates are unacceptably high. While this may reflect disease biology, a new approach to IBD surveillance is urgently needed. Interventions could include dedicated IBD surveillance lists, patient education around bowel preparation, and pre-screening for inflammation (e.g. faecal calprotectin). Cancer registry database linkage is now essential for us to identify IBD-CRC cases not identified by surveillance.
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Timakova, T. K., E. M. Gorbunova та V. I. Dorokhova. "К истории развития ветеринарной службы Ярославской области". Vestnik APK Verhnevolzh`ia, № 2(46) (30 червня 2019): 91–96. http://dx.doi.org/10.35694/yarcx.2019.46.2.019.
Повний текст джерелаАнотація:
Государственная ветеринарная служба Ярославской области прошла сложный путь развития и в настоящее время является самостоятельной структурой, обеспеченной высококвалифицированными кадрами. В дореволюционный период в Ярославской области отмечалась высокая заболеваемость и падёж сельскохозяйственных животных, что было связано с недостаточным количеством ветеринарных специалистов. Первые упоминания о ветеринарной службе Ярославской области датируются началом XIX века. Структура ветеринарной службы России начала складываться во второй половине XIX века: 2 декабря 1868 года было организовано Центральное ветеринарное управление при Министерстве внутренних дел с подчинёнными ему губернскими и уездными ветеринарными врачами. В Ярославской губернии до 1890 года было всего 2 земских ветеринарных врача и 10 фельдшеров. С 1903 года в Ярославской губернии начинают открываться ветеринарные лаборатории, а с 1906 года бактериологические кабинеты. В этот период наблюдаются изменения и в структуре государственной ветеринарной службы России. В Ярославской области ветеринарная служба с 2012 года стала самостоятельным органом исполнительной власти департаментом ветеринарии Ярославской области. В настоящее время ветеринарную деятельность в Ярославской области осуществляет областная ветеринарная лаборатория, а также станция по борьбе с болезнями животных.The State Veterinary Service of the Yaroslavl Region has passed a difficult path of development and is currently an independent structure provided with skilled workforce. In the prerevolutionary period in the Yaroslavl region there was a high incidence of disease and death loss of farm animals which was associated with an insufficient number of veterinary specialists. The first mention of the veterinary service of the Yaroslavl region dates back to the beginning of the 20 century. The structure of the veterinary service of Russia began to take shape in the second half of the 20 century: the Central Veterinary Administration under the Ministry of the Interior was organized on the 2nd of December, 1868 with its subordinate provincial and district veterinarians. In the Yaroslavl province until 1890 there were only 2 Zemsky veterinarians and 10 Veterinary Technicians. From 1903 veterinary laboratories began to open in the Yaroslavl province and from 1906 bacteriological rooms. During this period changes in the structure of the state veterinary service of Russia are observed. Since 2012 the veterinary service in the Yaroslavl region has become an independent executive body the veterinary department of the Yaroslavl region. Currently veterinary activities in the Yaroslavl region are carried out by the regional veterinary laboratory as well as the station of animal disease control.
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Gawali, P. B., M. G. Doiphode, and R. N. Nimje. "Colaba–Alibag magnetic observatory and Nanabhoy Moos: the influence of one over the other." History of Geo- and Space Sciences 6, no. 2 (September 16, 2015): 107–31. http://dx.doi.org/10.5194/hgss-6-107-2015.
Повний текст джерелаАнотація:
Abstract. The first permanent magnetic observatories in colonial India were established by the East India Company and under the Göttingen Magnetic Union. One of the world's longest running observatories was set up at Colaba (Bombay) in 1841, which was shifted to Alibag in 1904 to avoid electric traction effects on magnetic recordings. The observatory is located at the northwestern tip of Maharashtra, India, on the Arabian Sea. The magnetic data at Colaba were collected through eye-observation instruments from 1841 to 1872 and by photographic (magnetograph) instruments from 1872 to 1905, which reveal seasonal and other periodic effects on geomagnetic elements. Seasonal influence can be deciphered on the H minimum, but not on the maximum; the disturbances in March and April were opposite to those in December and January. D was maximum in 1880 (57' E) and minimum in 1904 (10' E). The data from 1882 to 1905 revealed that H annual inequality was influenced by 5.5-year periodicity, D by 13.5 days from 1888 to 1905, and I and Z by 11-year periodicity from 1894 to 1905 and 1873 to 1905, respectively. Secular variation of Z was parallel to that of I. Z exhibited an increasing trend from 1868 (12 874 nT) to 1905 (15 083 nT). The plan and location of Colaba–Alibag as well as the instruments used are discussed. The initial Colaba magnetic data containing "magnetic disturbances" was harnessed to identify the "disturbing point" on Earth. Nanabhoy Moos, the first Indian director, presciently hinted at a solar origin for magnetic disturbances, revealed the dependence of magnetic elements on the sunspot cycle, unraveled disturbance daily variation, and tried to understand the association, if any, between geomagnetic, seismological and meteorological phenomena. The two giant volumes published in 1910 attest to Moos' seminal work and his inventiveness in organizing and analyzing long series data. He also had a major role in moving Colaba magnetic observatory to Alibag. Thus, the observatory and Moos had a synergestic relationship influencing each other. The long data series has as much historical significance as scientific, which can bring out short- as well as long-term trends in geomagnetic data.
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Liu, Y., Y. Zhang, H. Song, Y. Ma, Q. Cai, and Y. Wang. "Tree-ring reconstruction of seasonal mean minimum temperature at Mt. Yaoshan, China, since 1873 and its relevance to 20th-century warming." Climate of the Past Discussions 10, no. 2 (March 6, 2014): 859–94. http://dx.doi.org/10.5194/cpd-10-859-2014.
Повний текст джерелаАнотація:
Abstract. It is very important to comprehend the climate variations in the vast regions of Central Plains of China. Current knowledge about climate changes of the past few hundred years in this region is primarily based on historical documents, and lack of evidences from the natural archives. However, these documents had somewhat artificially effects caused by the recorders, and not sufficient to fully understand natural climatic changes. In this paper, based on a significant correlation between the tree-ring width of Chinese Pine and observed instrumental data in the Mt. Yaoshan, China, we formulated a transfer function to reconstruct the mean minimum temperature (MMinT) from the previous December to the current June (Tmin_DJ) for the period 1873–2011. The reconstruction explained 39.8% of the instrumental variance during the calibration period of 1958–2011. High Tmin_DJ intervals with values greater than the 139 year average occurred in 1932–1965 and 1976–2006. The intervals 1878–1894 and 1906–1931 experienced a Tmin_DJ lower than the 139 year average. The ten highest Tmin_DJ years occurred after the 1950s, especially after 1996. A distinct upward trend in the Tmin_DJ series beginning in the 1910s was apparent, and the highest value occurred around 2000. The 20th-century warming signal was captured well by the Yaoshan Tmin_DJ temperature reconstruction, indicating that the temperature rise in the sensitive Central Plains of China region reflected the global temperature change. The Tmin_DJ reconstruction also matched several other temperature series in China with similar warm-cold patterns. The distinct spatial correlation between both observed and reconstructed series and CRU TS3.10 grid data indicates that our results may represent Tmin_DJ changes on a larger scale. The spatial correlation with sea surface temperature (SST) indicated that observed and reconstructed Tmin_DJ temperatures in the Mt. Yaoshan are closely linked to the West Pacific, Indian and North Atlantic Oceans as well as El Niño-Southern Oscillation (ENSO).
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Brandt, A. "Two cases of extrauterine pregnancy, cured by laparotomy." Journal of obstetrics and women's diseases 5, no. 1 (August 7, 2020): 40–42. http://dx.doi.org/10.17816/jowd5140-42.
Повний текст джерелаАнотація:
Case 1. Mrs. 28 years old, married for 2 years 4 months, appeared on December 27, 1889. The patient's complaints are as follows: Menstruation, which was always correct before and continued for 4 days, now lasts for 10 days. The last regulations were on October 1-4, they were absent in November, and since they were not shown even in December, the patient thought she was pregnant; On December 13th, I felt such a strong colicky contraction in the lower abdomen that I lost consciousness. After this attack, she has bleeding and pains in the lower abdomen are so severe every two hours that they make her writhe. Two cases of extrauterine pregnancy - cured by laparotomy.
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Shcherbak, A. E., and I. I. Ivanov. "Differential diagnosis of multiple neuritis. Polyesthesia and macroesthesia." Neurology Bulletin V, no. 1 (October 22, 2020): 160–70. http://dx.doi.org/10.17816/nb46649.
Повний текст джерелаАнотація:
During the 1894/95 academic year, we had the opportunity to observe the following case in the clinic.The patient, Adam M-sky, 30 years old, was admitted to the clinic on December 10, 1894. He fell ill in the month of the same year, after he slept, during the last rest, on the ground. When he woke up, he felt severe pain in his arms and legs on the left side (on which he slept), somehow reached with the help of others to the house, where he was forced to go to bed. There was a chill at night; More accurate data on fever cannot be reported.
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Skvortsov, V. N., A. S. Gorbaneva, V. Yu Oskolskaya, and A. R. Kravtsova. "ZEMSTVO SYSTEM VETERINARY MEDICINE OF THE OSTROGOZHSK COUNTY OF THE VORONEZH." VETERINARY PATHOLOGY, no. 4 (February 26, 2023): 82–89. http://dx.doi.org/10.23947/1682-5616-2022-4-82-89.
Повний текст джерелаАнотація:
Until 1891 the entire territory of the Ostrogozhsk County was covered by a single veterinary district. Based on the Zemstvo Assembly Resolution, starting from that year the county was divided into two veterinary districts – Rossoshansk and Ostrogozhsk. The Rossoshansk district included 15 volosts (small rural districts): Lizinovsk, Olkhovatsk, Rossoshansk, Rovensk, Aidarsk, Podgorensk, Belogorsk, Shaposhnikovsk, Evstratovsk, Vsesvyatsk, Maryevsk, Karayashnikovsk, Semeysk, Novo- and Staro-Kalitvyansk. The Ostrogozhsk district included the town and 12 volosts: Goncharovsk, DalnePolubyansk, Evdakovsk, Karpenkovsk, Kolybelsk, Lisyansk, Lushnikovsk, Markovsk, Novo-Sotensk, Ribensdorfsk, Sagunovsk and Trostyansk. The third Rovensk veterinary district was opened in 1897 to include seven volosts: Aidarsk, Lizinovsk, Rovensk, Shaposhnikovsk, Vsesvyatsk, Maryevsk and Olkhovatsk. In December 1897 the Olkhovatsk veterinary paramedical station was eliminated due to the paramedic's resignation. In February 1901, a veterinary outpatient clinic was opened in the town of Ostrogozhsk. From March 10, 1903, the veterinary staff of the first district increased by one paramedic, who was appointed by the Province Zemstvo to an independent station in the Marky village. The fourth Sagunovsk veterinary district was opened in 1906 to include six volosts: Sagunovsk, Markovsk, Belogorsk, Karayashnikovsk, Goncharovsk and Kolybelsk. In October 1907, the Olkhovatsk volost, which was recorded as part of the Rovensk district was assigned to the Rossoshansk. On August 1, 1909, the fifth Podgorensk district was opened in the county. There were two inpatient clinics in the county – in Saguny and Rovenky. In November 1910 the sixth district was opened in Staraya Kalitva village. In 1913 the seventh Olkhovatsk veterinary district was opened and new distribution of volosts and villages took place within the county territory. As of the beginning of 1914 seven veterinary physicians and twelve paramedics worked in the county. The First World War which began in July 1914, stopped the progressive evolution of zemstvo system veterinary medicine in the county as most of the physicians and paramedics were mobilised into the army.
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Pustovitenko, B., V. Svidlova, V. Knyazeva, and M. Bondar. "CRIMEAN BLACK SEA REGION." Zemletriaseniia Severnoi Evrazii [Earthquakes in Northern Eurasia], no. 22 (November 12, 2019): 44–55. http://dx.doi.org/10.35540/1818-6254.2019.22.03.
Повний текст джерелаАнотація:
Sixty-four local earthquakes in the energy class КП range from 4.7 to 10.1 were recorded in the Crimea in 2013. The total amount of released seismic energy decreased by two orders of magnitude compared to 2012. The focal mechanism solutions are obtained for three earthquakes: May 1 (Mwreg=3.8), October 15 (Mwreg=3.7), and December 9 (Mwreg=3.5). The earthquake on May 1 occurred in the eastern part of the region under the action of horizontal extensional stress. Two other earthquakes took place in the central zone of the region and indicate horizontal compressional stress. The earthquake on October 15 was felt on the Crime-an coast with an intensity of up to 4 (MSK-64). The parameters of the seismic regime for 2013 and the previous 5 years are considered. The highest level of seismic activity A10=0.4 in 2013 is attributed to the central part of the region, to the focal zone of a notable earthquake on October 15. In the Kerch-Anapa group of foci, the level of A10 did not change in comparison with 2012. The total contribution from earthquakes in 2013 to the tectonic deformation of the environment was insignificant, similar to the previous year 2012. The maximum strain rate V=1.010-9 year–1 is associated with a notable earthquake on October 15 and a se-ries of tremors on December 9.
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Shen, Samuel S. P., Christine K. Lee, and Jay Lawrimore. "Uncertainties, Trends, and Hottest and Coldest Years of U.S. Surface Air Temperature since 1895: An Update Based on the USHCN V2 TOB Data." Journal of Climate 25, no. 12 (June 15, 2012): 4185–203. http://dx.doi.org/10.1175/jcli-d-11-00102.1.
Повний текст джерелаАнотація:
Abstract This paper estimates the sampling error variances of gridded monthly U.S. Historical Climatology Network, version 2 (USHCN V2), time-of-observation-biases (TOB)-adjusted data. The analysis of mean surface air temperature (SAT) assesses uncertainties, trends, and the rankings of the hottest and coldest years for the contiguous United States in the period of 1895–2008. Data from the USHCN stations are aggregated onto a 2.5° × 3.5° latitude–longitude grid by an arithmetic mean of the stations inside a grid box. The sampling error variances of the gridded monthly data are estimated for every month and every grid box with data. The gridded data and their sampling error variances are used to calculate the contiguous U.S. averages and their trends and associated uncertainties. The sampling error variances are smaller (mostly less than 0.2°C2) over the eastern United States, where the station density is greater and larger (with values of 1.3°C2 for some grid boxes in the earlier period) over mountain and coastal areas. In the period of 1895–2008, every month from January to December has a positive linear trend. February has the largest trend of 0.162°C (10 yr)−1, and September has the smallest trend at 0.020°C (10 yr)−1. The three hottest (coldest) years measured by the mean SAT over the United States were ranked as 1998, 2006, and 1934 (1917, 1895, and 1912).
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Carlos Navarro Venegas. "The Nobel prize and its consequences." World Journal of Advanced Research and Reviews 15, no. 1 (July 30, 2022): 568–70. http://dx.doi.org/10.30574/wjarr.2022.15.1.0757.
Повний текст джерелаАнотація:
The origin of the Nobel Prize dates back to 1895, when Alfred Nobel made his last will and testament, donating most of his fortune to a series of prizes in Physics, Chemistry, Physiology or Medicine, Literature and Peace. However, the first was delivered in 1901 and since then every December 10, the date Nobel died. It is then a very precious achievement for some scientists and scholars who are nominated each year for their contributions in different disciplines and who, by being recognized by the Swedish Academy, go on to immortality, both in research and in university teaching at least.
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Stepanenco, N., V. Cardanets та N. Simonova. "EARTHQUAKES FELT IN MOLDOVA 2014: March, 29 with КP=12.5, Mw=4.7, September, 10 with КP=12.4, Mw=4.5 and November 22 with КP=14.3, Mw=5.8 (Romania–Moldova)". Earthquakes in Northern Eurasia, № 23 (15 грудня 2020): 288–97. http://dx.doi.org/10.35540/1818-6254.2020.23.29.
Повний текст джерелаАнотація:
All earthquakes felt in 2014 on the territory of Moldova occurred outside its borders, in the Vrancea and Pre-Carpathian regions (Romania). In 2014, the population of Moldova felt 13 earthquakes. The article discusses in detail the most powerful events, occurred on March 29, September 6, and November 22. The March 29 earthquake, Mw=4.7, hрР=136 km was felt in the eastern and southern counties of Romania (in 41 settlements), in the Odessa region of Ukraine, and also in the central and southern regions of the Republic of Moldova (22 points). The epicenter was situated in a bend of the Vrancea mountains. The earthquake on Sep-tember 10, Mw=4.5, hрР=108 km was felt in the eastern and southern counties of Romania (in 27 settlements), in the central and southern parts of Moldova (22 points), in the north of Bulgaria and in the Odessa region of Ukraine. Both earthquakes, March 29 and September 10, occurred under the action of prevailing near-horizontal compressive stress. The November 22 earthquake, Mw=5.8, hрР=37 km occurred in the southwestern part of Romania and turned out to be the most significant crust event for the instrumental observation period. Movement in the source occurred under the action of tensile stresses. Earthquakes in this zone continued until January 19, 2015. The largest aftershock was on December 7 with МwMED=4.4. Foci are associated with the activation of the Peceneaga-Camena fault. The main shock was felt in Romania (in 66 settlements) and neighboring countries: Bulgaria, Moldova (23 settlements), Ukraine (18 settlements). The isoseismal maps were constructed for all three earthquakes considered in detail in this work. The intensity at the epicenter of the November 22 earthquake reached I0=6, for other two events I0=5.
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Saryeva, G., Natalya Petrova, and L. Bezmenova. "KOPETDAG." Zemletriaseniia Severnoi Evrazii [Earthquakes in Northern Eurasia], no. 22 (November 12, 2019): 96–107. http://dx.doi.org/10.35540/1818-6254.2019.22.08.
Повний текст джерелаАнотація:
In 2013, the seismic process in the Kopetdag region was monitored by a stationary network of nineteen ana-log and two digital stations supported by eleven mobile digital stations. From September to December, eight GEOSIG-type digital sets of equipment were installed at eight analog stations – “Danata”, “Krasnovodsk”, “Nebitdag”, “Kenekesir”, “Kara-Kala”, “Gaurdak”, “Serniy” and “Serakhs” – with the prospect of further replacement of analog equipment. In total, 158 earthquakes with КР≥8.6 were recorded by Turkmenistan seismic stations during the year, and focal mechanisms were determined for 41 events. The installation of highly sensitive equipment did not lead to an increase in the number of registered earthquakes, since in 2013, the released seismic energy (ΣE=7.051012, J compared to ΣE=17.621012, J in 2012) and seismic activity decreased in the region’s territory (A10=0.032 compared to A10=0.038 in 2012). Despite the decrease of seismic activity in the region as a whole, in some areas (Balkhan-Caspian, the northern part of the Turkmen-Khorasan area), on the contrary, it increased. Particularly noticeable is the intensification of seismicity in the area of Magtymguly town, which began in 2012 in the form of swarms of earthquakes with increasing total energy, and on December 9, 2013, was manifested by an earthquake with КР=12.4, felt in the towns of Ser-dar and Magtymguly with an intensity of 2 on the MSK-64 scale and accompanied by a large number of aftershocks. The chain of aftershocks of the earthquake on December 9 was lined up in the northeast direction from the epicenter of the main shock, marking the western border of the earth's crust block activated in 2012–2013. The sublatitudinal segment of a line, passing through the epicenters of the main shock, after-shock on December 10, previous event of August 28 and ending with the location of the swarm No.1 of 2012, defined its southern boundary. Such an assumption about the configuration of the mobile block of the earth’s crust is supported by the northeastern and sublatitudinal orientation of the nodal planes of most focal mechanisms of 2012–2013 earthquakes in this area, and the presence of both reverse and normal fault components of a slip indicates an alternating pattern of movement on the block boundaries. Another major seismic event in Turkmenistan with КР=12.0 occurred on February 28 at 11h05m, 20 km West of the Germab seismic station, at the site of the intersection of the Germab fault and the Main Kopetdag fault. The earth-quake was felt with intensity I=3 in the village of Baharly, I=2–3 in Ashgabat. The movement in the source was a right-lateral strike-slip with a normal fault component along the north–north-west plane coinciding with the Hermab fault orientation
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Henson, Margaret Swett, and Malcolm D. McLean. "Papers Concerning Robertson's Colony in Texas. Volume XVII: December, 1838, through August 10, 1840: Sterling C. Robertson vs. Sam Houston, President of the Republic of Texas." Journal of Southern History 59, no. 2 (May 1993): 363. http://dx.doi.org/10.2307/2209811.
Повний текст джерела
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Abgaryan, G. R., H. V. Sargsyan, and N. V. Petrova. "FELT EARTHQUAKE of JULY 4, 2017 with ML=3.7, I0=5–6 to NORTHWEST of the 1988 SPITAK EARTHQUAKE SOURCE ZONE." Earthquakes in Northern Eurasia, no. 25 (December 20, 2022): 354–60. http://dx.doi.org/10.35540/1818-6254.2022.25.33.
Повний текст джерелаАнотація:
The instrumental data and results of macroseismic survey of the July 4, 2017 earthquake with ML=3.7, I0=5–6, occurred in the source zone of the devastating Spitak earthquake of 1988 with I0=10, are given. The earthquake was accompanied by a sound like an explosion. According to the focal mechanism parameters, a reverse faulting occurred along the NP1 plane of northwest strike and northeast dipping, or a thrust along the near-meridional NP2 plane dipping west. The migration of aftershocks to the north and east in October-December 2017 testifies in favor of choosing the NP1 nodal plane as the main one. An isoseismal map of the earthquake is constructed, according to which the isoseists are oriented to the northeast. The discrepancy between their orientation and the strike of the nodal planes is explained by the predominant influence on the macroseismic field of northeast oriented Akhourian fault, in the zone of which most of the surveyed settlements are located.
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Robertson, Ritchie, Maurice Gode, Jacques Le Rider, and Francoise Mayer. "Allemands, juifs et tcheques a Prague/Deutsche, Juden und Tschechen in Prag 1890-1924. Actes du colloque international de Montpellier 8-10 decembre 1994." Modern Language Review 94, no. 1 (January 1999): 256. http://dx.doi.org/10.2307/3736093.
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Serdiuk, Ya O. "Amanda Maier: a violinist, a pianist, a composer – the representative of Leipzig Romanticism." Aspects of Historical Musicology 17, no. 17 (September 15, 2019): 232–48. http://dx.doi.org/10.34064/khnum2-17.15.
Повний текст джерелаАнотація:
Background. The performance practice of recent decades demonstrates an obvious tendency to expand and update the repertoire due to the use of the works of those composers whose pieces had “lost” over time against to the pieces of their more famous contemporaries. At the same time, in sociology, psychology, culturology, gender issues are largely relevant. Musicology does not stand aside, applying the achievements of gender psychology in the study of composer creativity and musical performing (Tsurkanenko, I., 2011; Gigolaeva-Yurchenko, V., 2012, 2015; Fan, Liu, 2017). In general, the issue of gender equality is quite acute in contemporary public discourse. The indicated tendencies determine the interest of many musicians and listeners in the work of women-composers (for example, recently, the creativity by Clara Schumann attracts the attention of performers all over the world, in particular, in Ukraine the International Music Festival “Kharkiv Assemblies” – 2018 was dedicated to her works). The theme of the proposed work is also a response to the noted trends in performing practice and musicology discourse. For the first time in domestic musicology an attempt is made to give a brief overview of the life and career of another talented woman, whose name is little known in the post-Soviet space. This is a Swedish violinist, composer and pianist Amanda Röntgen-Maier (1853–1894), a graduate of the Stockholm Royal College of Music and the Leipzig Conservatory, a contemporary of Clara Schumann, J. Brahms, E. Grieg, with whom she and her husband – composer, pianist, conductor Julius Röntgen – were associated for enough long time by creative and friendly relationships. In the post-Soviet space, not a single work has been published that would be dedicated to the works of A. Maier. In European and American musicology, the composer’s personality and creative heritage is also not widely studied. Her name is only occasionally mentioned in works examining the musical culture and, in particular, the performing arts of Sweden at that time (Jönsson, Å., 1995, 151–156; Karlsson, Å., 1994, 38–43; Lundholm, L., 1992, 14–15; Löndahl, T., 1994; Öhrström, E., 1987, 1995). The aim of the proposed study is to characterize Amanda Meier’s creative heritage in the context of European romanticism. Research results. Based on the available sources, we summarized the basic information about the life and career of A. Maier. Carolina Amanda Erica Maier (married Röntgen-Maier ) was born on February 20, 1853 in Landskrona. She received the first music lessons from his father, Karl Edward Mayer, a native of Germany (from Württemberg), who worked as a confectioner in Landskrona, but also studied music, in particular, in 1852 he received a diploma of “music director” in Stockholm and had regular contracts. In 1869, Amanda entered to the Kungliga Musikaliska akademien (Royal College of Music) in Stockholm. There she learns to play several instruments at once: the violin, cello, piano, organ, and also studies history, music theory and musical aesthetics. A. Maier graduated from Royal College successfully and became the first woman who received the title of “Musik Direktor”. The final concert, which took place in April 1873, included the performance of the program on the violin and on the organ and also A. Maier’s own work – the Romance for Violin. In the spring of 1874, Amanda received the grant from the Royal College for further studies at the Leipzig Conservatory. Here, Engelbert Röntgen, the accompanist of the glorious orchestra Gewandhaus, becomes her teacher on the violin, and she studies harmony and composition under the guidance of Karl Heinrich Karsten Reinecke and Ernst Friedrich Richter. Education in Leipzig lasts from 1874 to 1876. In the summer and autumn of 1875, A. Maier returns to Landskron, where she writes the first major work – the Concerto for violin and orchestra in one-movement, D minor, which was performed twice: in December 1875 in Halle and in February 1876 with the Gewandhaus Orchestra under the direction of K. Reinecke. The further career of A. Maier, both performing and composing, developed very successfully. She made several major concert trips between 1876 and 1880: to Sweden and Norway, to Finland and St. Petersburg; she also played to the Swedish king Oscar II (1876); concerts were held with constant success. While studying in Leipzig, A. Maier met her future husband (the son of her violin teacher) Julius Röntgen, composer and conductor. They married 1880 in Landskrona. Their personal relationships included active creative communication, both playing music together, and exchanging musical ideas, getting to know each other’s works. Part of his chamber opuses, for example, the cycle of Swedish folk dances, A. Maier created in collaboration with her husband. An analogy with life of Robert and Clara Schumann may take place here, although the Röntgen spouses did not have to endure such dramatic collisions that fell to the lot of the first. After the wedding, Röntgen family moved to Amsterdam, where Julius Röntgen soon occupies senior positions in several music organizations. On the contrary, the concert and composing activities of A. Maier go to the decline. This was due both, to the birth of two sons, and to a significant deterioration in her health. Nevertheless, she maintains her violin skills at the proper level and actively participates in performances in music salons, which the family arranges at home. The guests of these meetings were, in particular, J. Brahms, K. Schumann, E. Grieg with his wife and A. Rubinstein. The last years of A. Maier’s life were connected with Nice, Davos and Norway. In the fall of 1888 she was in Nice with the goal of treating the lungs, communicating there with her friends Heinrich and Elizabeth Herzogenberg. With the latter, they played Brahms violin sonatas, and the next (1889) year A. Maier played the same pieces with Clara Schumann. Amanda Maier spent the autumn of 1889 under the supervision of doctors in Davos, and the winter – in Nice. In 1890, she returned to Amsterdam. His last major work dates back to 1891 – the Piano Quartet in D minor. During the last three years of her life, she visited Denmark, Sweden and Norway, where she performed, among other, her husband’s works, for example, the suite “From Jotunheim”. In the summer of 1889, A. Maier took part in concerts at the Nirgaard Castle in Denmark. In 1894, she returned to Amsterdam again. Her health seems stable, a few hours before her death she was conducting classes with her sons. A. Maier died July 15, 1894. The works of A. Maier, published during the life of the composer, include the following: Sonata in H minor (1878); 6 Pieces for violin and piano (1879); “Dialogues” – 10 small pieces for piano, some of which were created by Julius Röntgen (1883); Swedish songs and dances for violin and piano; Quartet for piano, violin, viola and cello E minor (1891). Still unprinted are the following works: Romance for violin and piano; Trio for violin, cello and piano (1874); Concert for violin and orchestra (1875); Quartet for piano, violin, viola and clarinet E minor; “Nordiska Tonbilder” for violin and piano (1876); Intermezzo for piano; Two string quartets; March for piano, violin, viola and cello; Romances on the texts of David Wiersen; Trio for piano and two violins; 25 Preludes for piano. The composer style of A. Mayer incorporates the characteristic features of the Romantic era, in particular, the Leipzig school. Lyric elements prevail in her works, although the composer is not alien to dramatic, heroic, epic images (the Piano Quartet E minor, some pieces from the Six Songs for Violin and Piano series). In the embodiment of such a circle of images, parallels with the musical style of the works of J. Brahms are quite clearly traced. In constructing thematic structures, A. Maier relies on the melody of the Schubert-Mendelssohn type. The compositional solutions are defined mainly by the classical principles of forming, which resembles the works of F. Mendelssohn, the late chamber compositions of R. Schumann, where the lyrical expression gets a clear, complete form. The harmonic language of the works of A. Maier gravitates toward classical functionality rather than the uncertainty, instability and colorfulness inherent in the harmony of F. Liszt, R. Wagner and their followers. The main instrument, for which most of the opuses by A. Maier was created, the violin, is interpreted in various ways: it appears both, in the lyrical and the virtuoso roles. The piano texture of chamber compositions by A. Maier is quite developed and rich; the composer clearly gravitates towards the equality of all parties in an ensemble. At the same time, piano techniques are reminiscent of texture formulas by F. Mendelssohn and J. Brahms. Finally, in A. Mayer’s works manifest themself such characteristic of European romanticism, as attraction to folklore, a reliance on folk song sources. Conclusions. Periods in the history of music seemed already well studied, hide many more composer names and works, which are worthy of the attention of performers, musicologists and listeners. A. Mayer’s creativity, despite the lack of pronounced innovation, has an independent artistic value and, at the same time, is one of such musical phenomena that help to compile a more complete picture of the development of musical art in the XIX century and gain a deeper understanding of the musical culture of this period. The prospect of further development of the topic of this essay should be a more detailed study of the creative heritage of A. Maier in the context of European musical Romanticism.
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Panchenko, A. M. "Book and Geographical Shop to sale editions of the General Staff (at Military Printing House)." Bibliosphere, no. 1 (March 30, 2018): 16–24. http://dx.doi.org/10.20913/1815-3186-2018-1-16-24.
Повний текст джерелаАнотація:
The article represents the history of creation and development of a typographical office and book and geographical shop to sale editions of the General Staff at the Military Printing House. It analyzes «Military Printing House Regulations» highly approved on December 30, 1860 and the «Military Printing House Regulations» put into operation by the order on the Defense Ministry No. 28 on February 10, 1895, concerning activity of the typographical office and Book and Geographical Shop to sale editions of General Staff at Printing House. The paper considers Rules of work of Book and Geographical Shop for the General Staff editions sale. It reveals features of books perchase in it by various categories of customers.
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Skidmore, James R., Kyle Kener, and Jose Castro Garcia. "Prevalence of Pediatric Periorbital Trauma at a US-Mexico Border Level 1 Trauma Center, 10 Year Retrospective Review." FACE 2, no. 4 (October 27, 2021): 336–40. http://dx.doi.org/10.1177/27325016211055220.
Повний текст джерелаАнотація:
Introduction: Due to its location in the middle third of the face, the periorbital area is exposed to external forces that may cause blunt and/or penetrating trauma. This anatomical location houses important structures for vision, cosmesis, and upper and lower facial skeletal stability. Trauma in this area puts the patient at risk for injuries to important structures, that, when damaged at early age, may have permanent debilitating consequences. Methods: After obtaining IRB approval, we evaluated ER admissions at a Level 1 Trauma Center located in the US-Mexico border over a 10-year-period. Inclusion criteria included patients younger than 18 years old with diagnosis of trauma to the face involving the periorbital region. Results: From January 2009 to December 2018, 1192 pediatric patients were admitted to the Level 1 Trauma Center with trauma that involved the periorbital area amongst other injuries. Mean age was 8, STD 5.2. 61.4% were male patients. The most common mechanism of injury was fall (365) followed by blunt trauma (305) and motor vehicle accident (MVA) (108). 29.4% of patients required admission, and 18.8% required a surgical intervention. Conclusion: Periorbital trauma in the pediatric population may bring lifelong consequences due to deformity, dysfunction, or loss of the structures that are contained within this anatomical area. Further studies are warranted to assess risk factors and to provide prevention measures to avoid trauma and complications due to injury to these important structures.
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Nicholson, Lindsey I., Michał Pętlicki, Ben Partan, and Shelley MacDonell. "3-D surface properties of glacier penitentes over an ablation season, measured using a Microsoft Xbox Kinect." Cryosphere 10, no. 5 (September 2, 2016): 1897–913. http://dx.doi.org/10.5194/tc-10-1897-2016.
Повний текст джерелаАнотація:
Abstract. In this study, the first small-scale digital surface models (DSMs) of natural penitentes on a glacier surface were produced using a Microsoft Xbox Kinect sensor on Tapado Glacier, Chile (30°08′ S, 69°55′ W). The surfaces produced by the complete processing chain were within the error of standard terrestrial laser scanning techniques, but insufficient overlap between scanned sections that were mosaicked to cover the sampled areas can result in three-dimensional (3-D) positional errors of up to 0.3 m. Between November 2013 and January 2014 penitentes become fewer, wider and deeper, and the distribution of surface slope angles becomes more skewed to steep faces. Although these morphological changes cannot be captured by manual point measurements, mean surface lowering of the scanned areas was comparable to that derived from manual measurements of penitente surface height at a minimum density of 5 m−1 over a 5 m transverse profile. Roughness was computed on the 3-D surfaces by applying two previously published geometrical formulae: one for a 3-D surface and one for single profiles sampled from the surface. Morphometric analysis shows that skimming flow is persistent over penitentes, providing conditions conducive for the development of a distinct microclimate within the penitente troughs. For each method a range of ways of defining the representative roughness element height was used, and the calculations were done both with and without application of a zero displacement height offset to account for the likelihood of skimming air flow over the closely spaced penitentes. The computed roughness values are on the order of 0.01–0.10 m during the early part of the ablation season, increasing to 0.10–0.50 m after the end of December, in line with the roughest values previously published for glacier ice. Both the 3-D surface and profile methods of computing roughness are strongly dependent on wind direction. However, the two methods contradict each other in that the maximum roughness computed for the 3-D surface coincides with airflow across the penitente lineation, while maximum roughness computed for sampled profiles coincides with airflow along the penitente lineation. These findings highlight the importance of determining directional roughness and wind direction for strongly aligned surface features and also suggest more work is required to determine appropriate geometrical roughness formulae for linearized features.
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Santos, Luan V. B., Daniel P. Monteiro, Caroline F. A. F. Sousa, Michelly D. F. Araújo, Lucia S. Fontes, and Alexandre Somavilla. "Social Wasps (Vespidae: Polistinae) in an Urban Park from Piauí, Brazil." Entomological Communications 3 (March 4, 2021): ec03009. http://dx.doi.org/10.37486/2675-1305.ec03009.
Повний текст джерелаАнотація:
Studies of social wasps (Vespidae: Polistinae) in Piauí State are scarce and only two have been carried out. Due to the lack of studies, we surveyed the wasp species in the Zoobotanical State Park in the urban area of Teresina, Piauí, Brazil. From December 2017 to May 2018, 10 expeditions were carried out using active collection with entomological nets and attractive traps with guava juice. A total of 282 individuals were collected distributed in six genera and 12 species. Parachartergus fraternus Gribodo, 1892 and Synoeca surinama (Linnaeus, 1767) are new records for Piauí, which now has 12 genera and 24 species registered for the state. Such data reveals the need to continue studying Polistinae in Piauí, in order to determine their real species distributions, help conserve natural areas and accurately manage these sites.
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Wihardi, Wilson, and Anas Lutfi. "Pembentukan Portfolio Optimal Untuk Berinvestasi pada Saham Perusahaan Perbankan di Bursa Efek Indonesia dengan Metode Sharpe, Treynor dan Jensen Periode 2013-2017." Jurnal Manajemen Bisnis dan Kewirausahaan 4, no. 3 (May 21, 2020): 74. http://dx.doi.org/10.24912/jmbk.v4i3.7920.
Повний текст джерелаАнотація:
The aim of this research is to find out the performance of the banking company stocks in Indonesia Stock Exchange, and which stocks is the best to form out a portfolio. The measurement in used is Sharpe Index, Treynor Index, and Jensen Index. The object in this research is the 10 banking companies with biggest capitalization in Indonesia Stock exchange due on 31 December 2017 or the last day of trading day in 2017. The conclusion of this research are the best banking company stocks based on Sharpe Indes is BBCA, based on Treynor Index is MEGA, and based on Jensen Index is BJBR. The Optimum Portfolio is consisted of 79,4 % BBCA, 16,9 % MEGA, and 3,7 % BJBR. Expected Return of this portfolio is 18,98 % per year and standard Deviation 7,2 %.
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Gagelmann, Nico, Simona Iacobelli, Linda Koster, Hareth Nahi, Anne-Marie Stoppa, Tamás Masszi, Denis Caillot, et al. "Impact of Extramedullary Disease in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation: A Study By the EBMT Chronic Malignancies Working Party." Blood 128, no. 22 (December 2, 2016): 2266. http://dx.doi.org/10.1182/blood.v128.22.2266.2266.
Повний текст джерелаАнотація:
Abstract Introduction Multiple myeloma (MM) is characterized by a proliferation of plasma cells with a strong dependence on the bone marrow (BM) microenvironment. However, in some MM patients this proliferation escapes the BM resulting in extramedullary disease (EMD) with two types of involvement: 1) paraskeletal (PS) and 2) extramedullary (EM), involving either skin/lymph nodes (EMS) or organs (EMO). EMD is considered to be associated with poor prognosis. Autologous stem cell transplantation (ASCT) in MM is standard therapy in first line therapy in eligible patients, but only limited reports on outcome of EMD after ASCT exist. Methods Within the European Society for Blood and Marrow Transplantation (EBMT) registry, 4658 patients (female n=1898, male n=2760) who received upfront ASCT were reported between January 2005 and December 2014 with available data on EM involvement at time of diagnosis. 3802 patients had no EMD (MM group), while 677 had PS and 179 EM involvement, including EMS (n=68) or EMO (n=111). The median age of the patients was 59 years (range 22 - 77). The stage according ISS at diagnosis was I (n=1229), II (n=1174) and III (n=865). All patients received an upfront single (n=4250) or tandem (n=408) ASCT. Salmon and Durie classification stage B was seen more frequently in EM (31%), than in MM (17%) or PS (16%) (p< 0.001). More EM had ≥ 2 different sites of involvement than PS patients (20% versus 4%, p< 0.001). Tandem ASCT was applied to 15% in the PS group compared to 8% in the MM and 10% in the EM group (p< 0.001). Primary end point was 5 year progression-free survival (PFS). Results At ASCT 18% of MM patients achieved a complete remission (CR) compared to 20% of PS and 12% of EM patients (p=0.058). MM and PS patients showed similar 5 year PFS (28% versus 29%, p= 0.74) in the univariate analysis with a median PFS of 31 versus 33 months. In contrast, EM patients had a significant worse median PFS (21.5 months) and 5 year probability (22%) than MM patients (28%) as well as PS patients (29%) (p< 0.001). Five year probability of OS were higher in MM compared to PS (67% versus 63%, p=0.05) and to EM (67% versus 49%, p< 0.001). Furthermore, the difference in 5 year OS between PS and EM involvement reached statistical significance (63% versus 49%, p< 0.001). When analyzing PFS according to the number of sites involved, the median PFS in PS patients was 35 for 1 versus 24 months for ≥ 2 sites and in EM patients 24 versus 17 months (p=0.003). Other significant factors for worse PFS in the univariate analysis were: IgA-type (p< 0.001), Salmon and Durie stage B (p< 0.001), ISS II and III (p< 0.001, respectively), while favorable factors were CR (p< 0.001) and female sex (p< 0.001). In a subanalysis comparing EMS and EMO, the median PFS was significantly worse for EMS than EMO (20 versus 25 months, p=0.024). Cox proportional hazards regression considering independent factors for worse PFS yielded: EM (HR 2.88, 95% CI 1.90 - 4.37), IgA (HR 1.31, 95% CI 1.15 - 1.48) as well as Salmon and Durie stage B (HR 1.26, 95% CI 1.06 - 1.51), while improved PFS was seen for CR (HR 0.47, 95% CI 0.36 - 0.61) and ISS I (HR 0.70, 95% CI 0.60 - 0.83). Conclusion This EBMT registry study demonstrates that EMD manifestation in patients with MM is an independent risk factor for worse outcome after ASCT. Within the EMD group, non-paraskeletal extramedullary manifestation, EMS and involvement of 2 or more sites resulted in worse PFS. Disclosures Leleu: TEVA: Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria; LeoPharma: Honoraria; Pierre Fabre: Honoraria; Amgen: Honoraria; Bristol-Myers Squibb: Honoraria; Takeda: Honoraria; Celgene: Honoraria; Janssen: Honoraria. Delforge:Janssen: Honoraria; Celgene: Honoraria; Amgen: Honoraria. Kröger:Riemser: Honoraria, Research Funding; Sanofi: Honoraria, Research Funding; Novartis: Honoraria, Research Funding; Neovii: Honoraria, Research Funding.
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Piscos, James Lotero. "Stewardship Towards God’s Creation Among Early Filipinos: Implications to Inculturated Faith." Bedan Research Journal 4, no. 1 (April 30, 2019): 1–23. http://dx.doi.org/10.58870/berj.v4i1.1.
Повний текст джерелаАнотація:
An integral inculturated faith is anchored to the Filipino cultural heritage and identity. Primal cosmic beliefs and practices carried the holistic customs of stewardships towards God’s creation where it embodied the union and mutuality of the natives to nature rather than control and subordination. The research utilized primary materials written by Spanish ethnographers in the 16th-17th century. Although their observations were from the colonizers’ perspectives, it still revealed beliefs and practices at that time common among early Filipinos. One needs to filter and decipher those accounts to unearth early Filipinos experiences of oikenomous. Although the study was limited to the Tagalogs, still the dynamics of power-relations between the inhabitants and nature were demonstrated using the lenses of Foucault’s discourse on power. The findings of the research could have implications to inculturated faith given the open atmosphere of the Church for its renewed evangelization that includes stewardship towards God’s creation where harmony and communion with Mother Earth strengthens our bonds with God and find each other in a place we truly call a home.ReferencesPre-hispanic influence on filipino culture. (1958). Sunday Times Special Issue on the Foundations of Filipino Culture, pp. 2-5.Two lectures: Critique and power. (1998).Blair, E. and Robertson, A. (1903-1990). The Philippine islands, 1493-1898: explorations by early navigators, Descriptions of the islands and their peoples, their history and records of the catholic missions, as related in contemporaneous books and manuscripts showing the political, economic, commercial and religious conditions of those islands from their earliest conditions with european nations to the close of the nineteenth century. (eds. at annots. ), 55. Cleveland: B & RCatholic Bishops Conference of the Philippines. (1991). Acts and decrees of theChirino, P. (1603). Relacion de las yslas Filipinas. 12, 174-321. Madrid: B & R.Colin, F. (1663). Labor evangelica. 40, 38-97. Madrid: B & RDavid, M., Mauro, B. & Alessandro, F. (Eds.). (1971). Society Must Be Defended: Lectures at the College de France, 1975-76. New York: Picador.Discipline and Punish: The birth of the prison. (1977). New York: Random House Inc.Donoso, I. et al.(n.d.) Transcribed and eds. Boxer Codex of 1570 (2018). Quezon City: Vibal Publishing.Filipino indigenous ethnic communities: Patterns, variations, and typologies. (1998). Quezon City: Punlad Research House, Inc.Filipino prehistory: Rediscovering precolonial heritage. (1998). Quezon City: Punlad Research House, Inc.Filipino worldview: Ethnography of local knowledge. (2001). Quezon City: Punlad Research House, Inc.Flannery, A. (1984). Vatican Council II: The Conciliar and Postconciliar documents. New York: Costello Publishing Co.Foucault, M. (1972). The archaeology of knowledge and the discourse on language. Translated by A.M. Sheridan Smith. New York: Pantheon Books.Fox, R. (1966). “Ancient filipino communities.” Filipino cultural heritage. Edited by F. Landa Jocano. Manila: Philippine Women’s University.Francis, Pope. (2015). Laudato si. Vatican Press. https://dokumen.tips/documents/notes-on-philippinedivinities.html.Hurley, R. (Ed) The history of sexuality: An introduction. (1990). 1..New York: Vintage Books.Jocano, L. (1969). Outline of Philippine mythology. Retrieved from https://www.amazon.com/Outline-Philippine-Mythology-Landa-Jocano/dp/1790400864#reader_1790400864 on December 10, 2018Kelly, M. (Ed). (1998). Foucault/Habermas Debate. Cambridge: The MIT Press.Licuanan, V. and Llavador, M. (1996) Philippines under Spain. (eds and annots). 6, Manila: National Trust for Historical and Cultural Preservation of the Philippines.Loarca, M. (1582). Relacion de las Yslas Filipinas. 5, 38-252. Madrid: B & RMadness and civilization: A history of insanity in the age of reason. (1965) London: Random House Inc.Morga, A. (1609). Sucesos de las Islas Filipinas. 15, 25-288. Mexico: B & RNational Historical Commission. (1887). Coleccion de documents ineditos de ultramar, Madrid.Notes on Philippine Divinities. (1968). Asian Studies.Pastells, P. (1925) Historia general de Filipinas in catalogo de los documentos relativos alas Islas Filipinas. Barcelona.Pigafetta, A. (1522). The first voyage around the world. 33, 24-266. Madrid: B & RPlasencia, J. (1589). Customs of the Tagalogs. 7, 173-198. Manila: B & RPre-history of the Philippines. (1967). Manila: National Museum.Ramos, M. (1990). Philippine myths, legends and folktales. CreateSpace Independent Publishing Platform.San Agustin, G. (1998) Conquistas de las Islas Filipinas: 1565-1615. (Bilingual Edition.) Translated by Luis Antonio Maneru. Manila: San Agustin Museum.Second Plenary Council of the Philippines. Manila: CBCP Press.Sulod Society. (1968). Quezon City: Punlad Research House, Inc.Villote, R. (1987). My tenth hour. Syneraide Consultaties.Zaide, G., (1990) Documentary sources of Philippine History. (eds. at annots.) 14, Manila: National Bookstore.
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Monforte Porto, J. Á., A. San Román Uría, C. Llanes Álvarez, G. Humada Álvarez, I. Sevillano Benito, S. Cepedello Pérez, R. Hernández Antón, and S. Gómez Sánchez. "The psychotic patient at the General Hospital." European Psychiatry 33, S1 (March 2016): S151—S152. http://dx.doi.org/10.1016/j.eurpsy.2016.01.274.
Повний текст джерелаАнотація:
BackgroundPatients with schizophrenia have a higher prevalence of physical illness and a higher mortality from natural causes than the general population, which is a reason why they can be hospitalized for medical and surgical pathologies.AimsTo determine the demand, the reason for consultation and the sociodemographic characteristics of the psychotic patient admitted at the general hospital.MethodsSociodemographic variables (age, sex, marital status, education, place of residence, residential housing, with who they live, work status) and health care (service of origin, type of request and its relevance, complaints, days of delay between the request and assistance, number of visits, average length of stay).Study designProspective epidemiological study of 80 psychotic patients (F.2 ICD-10), from the total of 906 consults solicited from 1 January 2012 until 31 December 2014. Bioethical considerations: compliance with these principles justice, non-maleficence, autonomy and beneficence.ResultsThe average age is 58.34 years old, 60% were male, 73.8% single, 81.3% with primary education, 52.5% living in urban areas; and the 88.8% of cases were pensioners. The Departments that generate a greater demand are Internal Medicine (53.8%), Orthopaedic Surgery (10%), Pneumology (8.8%) and ICU (8.8%). The most frequent reasons for consultation are assessment/treatment setting (77.5%), abnormal behavior (30%), disorientation (18.8%) and psychotic symptoms (18.8%).ConclusionsThe typical profile of psychotic patients hospitalized for medical-surgical diseases is a male, middle-aged, single, with primary education and pensioner; from whom it's sued consultation for adjusting of treatment, and secondly for abnormal behavior.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Goes, Karina Cyganczuk, Hsia Hua Sheng, and Rafael Felipe Schiozer. "Contingent Convertibles and their Impacts on the Optimization of the Capital Structure of Brazilian Banks Under Basel III." Revista Contabilidade & Finanças 27, no. 70 (March 1, 2016): 80–97. http://dx.doi.org/10.1590/1808-057x201501350.
Повний текст джерелаАнотація:
Banks around the world maintain excess regulatory capital, whether to minimize capitalization costs or to mitigate risks of financial difficulties. However, it was only after the financial crisis of 2008 that the quality of capital gained greater importance among international regulators, through the Third Basel Accord (Basel III), which suggested a capital structure formed of the new equity and debt hybrid instruments, that is, Contingent Convertibles (CoCos), which have the main goal of recapitalizing banks automatically when they show signs of financial difficulties. Using the continuous-time structural model developed by Koziol and Lawrenz (2012), with December 2013 as a reference, this paper analyzes the capital structure of the 10 biggest Brazilian banks in terms of total assets, comparing their current structures - with only subordinated debts - with the structure proposed in Basel III, composed solely of contingent convertibles, with a view to verifying the influence of CoCos in banks' risks and evaluating the effectiveness of this Basel III recommendation. Through the evidence obtained using the model mentioned, this paper's main contribution is in demonstrating that the use of CoCos would optimize the capital structure of banks under the restrictions of Basel III, considering these are effective. If not, the automatic recapitalization of these instruments could be used for shareholders' own benefit, thus increasing the likelihood of banks experiencing financial difficulties, which could cause a new financial crisis, like that which occurred in 2008.
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Valle, R. A. del, J. M. Lirio, J. C. Lusky, J. R. Morelli, and H. J. Nuñez. "Jurassic trees at Jason Peninsula, Antarctica." Antarctic Science 9, no. 4 (December 1997): 443–44. http://dx.doi.org/10.1017/s0954102097000576.
Повний текст джерелаАнотація:
Jason Peninsula (66°10'S, 61°00'W) is a prominent feature extending some 80 km into the Larsen Ice Shelf from the eastern coast of the Antarctic Peninsula, and consists of widely spaced rock exposures and several ice-domes with elevations up to some 600 m (Fig. 1). The feature was first seen from seaward on 1 December 1893 by Captain C.A. Larsen, who named one of the high summits “Mount Jason” after his ship. Leading the 1902–1904 Swedish Antarctic Expedition, Dr Otto Nordenskjöld observed the area from Borchgrevink Nunatak (66°03'S; 62°30'W) and reported that the summits seen by Larsen were separated from the Antarctic Peninsula. The name “Jason Island” was subsequently adopted for this feature, but in the 1950s researchers belonging to the currently named British Antarctic Survey (BAS) determined Larsen's discovery to be a large peninsula, underlain mainly by calc-alkaline volcanic rocks.
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Segbefia, C. I., L. A. Renner, Y. Dei-Adomakoh, and J. Welbeck. "Changing Pattern of Childhood Cancers at Korle Bu Teaching Hospital, Accra, Ghana." Postgraduate Medical Journal of Ghana 2, no. 2 (July 12, 2022): 65–67. http://dx.doi.org/10.60014/pmjg.v2i2.35.
Повний текст джерелаАнотація:
Background: Worldwide, the incidence of childhood cancers is increasing and majority of children with cancers live in developing countries. The main aim of the study was to determine the current pattern of childhood malignancies at Korle Bu Teaching Hospital(KBTH), Accra.Methods: A retrospective review of registry data from the KBTH paediatric oncology unit between January 1, 2008 and December 31, 2011 was conducted, and results analysed.Results: Out of 495 new cases of cancer, lymphomas (30.7%), leukaemias (18.8%) and retinoblastomas (15.8%) were the commonest cancers diagnosed. CNS tumours were rare (3.4%). Overall, the male: female ratio was 1.3:1. Most patients (232/495; 47%) were inthe 5-10 year age group and majority of embryonal tumours were diagnosed in the 0-4 year age group. The peak ages for Burkitt’s lymphoma and acute lymphoblastic leukaemia were similar, in contrast to reports from developed countries.Conclusion: The number of children diagnosed with cancers at KBTH has increased significantly. Concerted efforts and advocacy towards improving childhood cancer care are required.
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Salehi, Mitra, Jalal Mardaneh, Hamid Reza Niazkar, Mohammadhaasan Minooeianhaghighi, Elahe Arshad, Fateme Soleimani, and Alireza Mohammadzadeh. "Prevalence and Subtype Analysis of Blastocystis hominis Isolated from Patients in the Northeast of Iran." Journal of Parasitology Research 2021 (January 13, 2021): 1–8. http://dx.doi.org/10.1155/2021/8821885.
Повний текст джерелаАнотація:
Blastocystis hominis is the most common intestinal parasite found in humans and many other hosts. Pathogenicity of Blastocystis spp. remains controversial, and it has been suggested that it may be associated with specific subtypes of the organism. This study identified the B. hominis subtypes and their prevalence rates in the northeast of Iran. A total of 1878 samples were collected from the northeast of Iran from January to December 2017. The patients’ demographic details were recorded. Samples were examined by a wet mount, and genomic DNA was extracted from positive samples. Also, PCR was done on the positive samples, and sequencing and phylogenetic analysis were subsequently performed. From 1878 collected stool samples, 152 (8.1%) Blastocystis samples were detected by the microscopic method. Of the 152 samples, Blastocystis spp. were found in 53.6% of the men and 28.9% of the women who showed clinical gastrointestinal symptoms, and a significant relationship was observed between gender and clinical symptoms ( P = 0.002 ). A meaningful relationship was found between the season and infection with this parasite ( P value = 0.003). The results of the sequencing of 22 PCR products showed the dominance of ST3, which was isolated from 10 (45.45%) patients, while ST1, ST2, and ST7 were found in 4 (18.19%), 7 (31.81%), and 1 (4.55%) patients, respectively. In this study, ST7 had a low prevalence in the northeast of Iran, and similar to previous studies, ST3 was the dominant subtype.
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Rakhmanov, Rofail Salykhovich, Elena Sergeevna Bogomolova, and Denis Alekseevich Narutdinov. "Bioclimatic characteristics of the regions of the Russian region from the standpoint of assessing the health risk of the population by effective temperature." Sanitarnyj vrač (Sanitary Doctor), no. 4 (April 1, 2021): 38–46. http://dx.doi.org/10.33920/med-08-2104-04.
Повний текст джерелаАнотація:
We calculated the effective temperatures based on 10-year data for temperatures (monthly average and minimum), wind speeds (monthly average and maximum) and relative air humidity in the climatic zones of the Krasnoyarsk Territory (subarctic No. 1) and temperate continental (Krasnoyarsk (object No. 2) and Minusinsk (3) We assessed the health risk.In winter, in the subarctic zone, the temperature is –23.3 ± 1.5 0 C (minimum –30.2 ± 2.1 0 C), in object No. 2 — –17.3 ± 1.6 0 C (–19.3 ± 1.0 0 С) and object No. 3 — –19.9 ± 1.4 0 С (–25.5 ± 1.9 0 С). In spring at object No. 1 it varied from –16.5 ± 1.7 0 С to + 1.6 ± 1, 0 0 С, object No. 2 — from –3.9 ± 0.9 0 С to + 9.4 ± 0.5 0 С, object No. 3 — from –4.5 ± 0.9 to + 10.6 ± 0.4. Temperatures ranged from + 8.2 ± 0.9 0 C to –17.8 ± 1.2 0 C (object No. 1), from + 9.4 ± 0.5 0 C to –7.5 ± 0.9 0 C and from +10.4 ± 0.4 0 C to –6.4 ± 1.0 0 C. In summer, the temperature was 19.9 ± 0.9 0 C, 18.8 ± 0.3 0 C, and 19.8 ± 0.4 0 C, respectively. Wind speed at object No. 3.6 ± 0.05 m/s in July increased to 5.4 ± 0.2 m/s in December (maximum 16.2 m/s); No. 2 in July 1.4 ± 0.05 m/s, in October-May 1.8 ± 0.2–2.1 ± 0.07 (maximum in December 10.1 ± 0.1 m/s); No. 3 minimum wind in January and February (1.1 ± 0.1 m/s), maximum 10.7 ± 0.6 m/s in May. A moderately dry climate is recorded during 2, 4 and 5 months. In the conditions of Krasnoyarsk and Minusinsk in the spring, humidity drops to the limits of dry air. Average effective temperatures indicated a possible risk of frostbite in the subarctic zone after 20–30 minutes within 2 months; at minimum temperatures and maximum winds in March, frostbite in 20–30 minutes, in November, December and February in 10–25 minutes; in January — in 5 minutes. In the Krasnoyarsk region in January frostbite is possible within 20–30 minutes, in Minusinsk in February in 20–30 minutes, in January 10–15 minutes. Heat stress is undefined.
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Rahman, MA, M. Imran, M. Ikrum, MH Rahman, and MG Rabbani. "Effects of Planting Date and Growth Hormone on Growth and Yield of Cauliflower." Journal of Environmental Science and Natural Resources 9, no. 2 (April 14, 2017): 143–50. http://dx.doi.org/10.3329/jesnr.v9i2.32185.
Повний текст джерелаАнотація:
An experiment was conducted at the Horticulture Farm of Bangladesh Agricultural University, Mymensingh, during the period from October 2014 to March 2015 to study the effects of planting date and growth hormone on the growth and yield of cauliflower. The experiment consisted of two factors; Factor A: Three planting dates, such as P1: Planting on 1 November; P2: Planting on 15 November and P3: Planting on 1 December; Factor B: Four levels of Growth hormone, such as H0: No Hormone (control); H1: 10 ppm IAA (Indole-3 Acetic Acid); H2: 70 ppm GA3 (Gibberellic Acid) and H3: 10 ppm IAA + 70 ppm GA3. The experiment was laid out following Randomized Complete Block Design (RCBD) with three replications. In case of planting date, the highest plant height (63.26 cm), number of leaves per plant (24.13), leaf length (59.26 cm), leaf breadth (19.31 cm) at harvest, curd diameter (22.25 cm), marketable yield per hectare (28.11 t ha-1) were recorded from P2 and the lowest of those parameters were recorded from P3. In case of growth hormone the highest plant height (63.10 cm), number of leaves per plant (23.66), leaf length (59.05 cm), leaf breadth (18.98 cm) at harvest, curd diameter (22.39 cm), marketable yield per hectare (29.88 t ha-1) were recorded from H3 and the lowest of those perameters were recorded from H0. Combination of planting date and growth hormone the highest plant height (65.96 cm), number of leaves per plant (26.42), leaf length (63.64 cm), leaf breadth (20.92 cm) at harvest, curd diameter (25.75 cm), marketable yield per hectare (31.03 t ha-1) were recorded from planting on 15 November and 10 ppm IAA with 70 ppm GA3 (P2H3) and the lowest parameters (21.75 t ha-1) were recorded from planting on 1 December and no hormone (P3H0). It is apparent from the above results that the combination of planting on 15 November and 10 ppm IAA with 70 ppm GA3 (P2H3) was more productive from the other combinations.J. Environ. Sci. & Natural Resources, 9(2): 143-150 2016
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Ku, Eu Jeong, Gun Woo Won, Yong Hee Lee, Dong-Hwa Lee, Hyun Jeong Jeon, and Tae Keun Oh. "Genetic variation in TCF7L2 rs7903146 correlating with peripheral arterial disease in long-standing type 2 diabetes." Diabetes and Vascular Disease Research 17, no. 1 (November 27, 2019): 147916411988847. http://dx.doi.org/10.1177/1479164119888475.
Повний текст джерелаАнотація:
Aim: The aim of this study was to investigate the association between the transcription factor 7-like 2 gene ( TCF7L2) rs7903146 polymorphism and peripheral arterial disease in type 2 diabetes. Methods: In total, 1818 Korean type 2 diabetes patients were enrolled from January 2013 to December 2017. Subjects were categorized into two groups according to their duration of type 2 diabetes: long (⩾10 years, n = 771) and short (<10 years, n = 1047) durations. A multivariate logistic regression model was used for assuming an additive effect on peripheral arterial disease for the presence of a variant allele in TCF7L2 rs7903146. Results: The frequency of the minor T-allele was 7.6% ( n = 139), and this allele was significantly associated with a 2.6-fold higher risk of peripheral arterial disease (odds ratio = 2.595, 95% confidence interval = 1.177–5.722, p = 0.018) in patients exhibiting a long duration of type 2 diabetes (⩾10 years). This result was significant after adjusting for age, sex, body mass index, familial history of diabetes, smoking, duration of diabetes and laboratory measurements, which included glycated haemoglobin, fasting plasma glucose and lipid profiles. In patients with diabetes < 10 years, there was no significant association between TCF7L2 rs7903146 and peripheral arterial disease (odds ratio = 1.233, 95% confidence interval = 0.492–3.093, p = 0.655). Conclusion: Our results provide evidence that genetic variation in TCF7L2 rs7903146 could increase risk for peripheral arterial disease in patients exhibiting long-standing type 2 diabetes.
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Vegunta, Ravindra K., Alya All, Lizabeth J. Wallace, Diane M. Switzer, and Richard H. Pearl. "Laparoscopic Appendectomy in Children: Technically Feasible and Safe in All Stages of Acute Appendicitis." American Surgeon 70, no. 3 (March 2004): 198–202. http://dx.doi.org/10.1177/000313480407000303.
Повний текст джерелаАнотація:
This is a retrospective outcomes analysis of pediatric open and laparoscopic appendectomy in a children's hospital. One hundred three children underwent appendectomy for appendicitis by two pediatric surgeons from August 1998 to December 2002. Patients were divided into two groups, laparoscopic appendectomy (LAP) and open appendectomy (OAP), and were further subdivided by diagnosis: normal (NL), acute (AA), and ruptured (RA). There were no differences in age, sex, race, or zip codes between groups. Median age was 10 years. In the acute phase, 28 patients underwent OAP and 65 underwent LAP whereas 10 patients underwent interval appendectomy (IA) 6 weeks after percutaneous drainage of established abscesses (eight were LAP vs two OAP). In the remaining patients, the appendix was normal in 17 (18.4%) and ruptured in 24 (25.8%) pathologically. LAP took longer to perform (57 minutes vs 34.5 minutes) at higher cost ($3718 vs $1858) than OAP. Overall complications were lower in the LAP group (17% vs 29%), and LAP for RA had significantly fewer total complications (25% vs 62.5%). Intra-abdominal abscess increased following LAP: 9.2 per cent versus 3.6 per cent. Length of stay was shorter for LAP versus OAP in both AA (2.0 vs 2.5 days) and RA (5.5 vs 7 days).
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Maluf, Fernando Cotait, Suelen P. S. Martins, Deusdedit Cortêz Vieira Silva Neto, Gustavo Werutsky, Jose Augusto Rinck Jr, Diogo Assed Bastos, Roberto Odebrecht Rocha, et al. "Survival outcomes of metastatic castration-resistant prostate cancer in Brazil (LACOG 1818)." Journal of Clinical Oncology 41, no. 6_suppl (February 20, 2023): TPS272. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.tps272.
Повний текст джерелаАнотація:
TPS272 Background: Treatment of metastatic castration-resistant prostate cancer (mCRPC) has been steadily evolving during the last decade, but access remains a significant issue in low- and middle-income countries (LMICs). As novel therapies emerge and translate into clinical practice, the gap in treatment patterns between patients who do or do not have access to these therapies is expected to increase. The resulting disparities in outcomes are likely to be more noticeable in countries with pronounced inequality, such as Brazil. In Brazil, while a minority of patients have private insurance and have access to nearly all available treatment options, approximately 75% of patients depend on the public health system, which is unable to afford most of the recent treatment innovations for mCRPC, such as novel hormonal agents (NHA) or PARP inhibitors. LACOG 1818 was developed to investigate and compare outcomes of patients with mCRPC treated at private and public hospitals in Brazil. Methods: LACOG 1818 (NCT04962919) is a retrospective multicentric study investigating disparities in cancer treatment and survival among public and private institutions in Brazil. Patients with mCRPC diagnosed within January 2014 and December 2017 will be included and their data will be abstracted from medical records. Primary endpoint is cause-specific survival, comparing patients from private and public institutions. We estimate that 299 events are needed to detect a hazard ratio of 0.75 indicating a lower risk of prostate cancer-related death for patients treated at private institutions with a power of 80% and a bicaudate significance level of 10%. Considering a follow up of 24 months and a median cause-specific survival of 20 months in patients from public institutions, 590 patients are planned to be included. Secondary endpoints include describing comorbidities, sociodemographic and clinicopathological characteristics of patients with mCRPC; comparing overall survival of patients with mCRPC treated at public and private institutions; comparing treatments patterns of patients with mCRPC treated at public and private institutions; and describing skeleton-related complications, bone-directed treatments, and admission rates. From January 2020 to August 2022, 244 of planned 590 patients have been enrolled in 7 Brazilian centers. Additional 12 centers are still planned to open before 2023. Results are expected in the first semester of 2023. Clinical trial information: NCT04962919 .
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JABA, Jagdish, T. PAVANI, Sumit VASHISTH, Suraj Prasad MISHRA, and Hari Chand SHARMA. "Assessing the impact of varietal resistance and planting dates on pest spectrum in chickpea." Acta agriculturae Slovenica 118, no. 1 (April 4, 2022): 1. http://dx.doi.org/10.14720/aas.2022.118.1.2096.
Повний текст джерелаАнотація:
<p class="042abstractstekst">The cotton bollworm <em>Helicoverpa armigera</em> [Hübner (1808)] is one of the most widely spread pest which limits the chickpea production, while the beet armyworm, <em>Spodoptera exigua</em> (Hübner, 1808) has emerged as a serious pest in recent years, in southern India and parasitic wasp <em>Campoletis chlorideae</em> Uchida, 1968 is an important larval parasitoid which naturally manages both pests under field condition. Insecticides adoption leads to development of resistance in pod borer. In view of climate change scenario, the focus of the present studies was the identification of climate resilient cultivars of chickpea for pod borers and the results reveled, that there were significant variations in the level of eggs and larval population among the genotypes. Across seasons, the crop sown in October recorded the maximum number of eggs. ‘ICC 3137’ had the highest number of <em>H. armigera</em> eggs (11.6) across seasons. ‘JG 11’, (6.3) in 2012 and’ ICCV 10’ (3.6) in 2013 recorded the lowest number of <em>H. armigera</em> eggs. During 2014-15, the maximum(80.7) <em>H. armigera</em> larval incidence was observed in October sown crop and the lowest (21.1) in January crop. The number of <em>S. exigua</em> larvae were substantially higher in the December crop. For all seasons, the highest number of <em>C. chlorideae</em> were found in October crop. Across seasons, multiple regression analysis for both pest had a strong interaction with weather patterns.</p>
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Rasco, Drew W., Albiruni Ryan Abdul Razak, Ali Raza Khaki, Alexander I. Spira, Ching-Chang Hwang, Anh N. Diep, Maike Schmidt, Roo Vold, Sophia Majeed, and Dylan M. Glatt. "Safety, efficacy, and PKPD of 23ME-00610, a first-in-class anti-CD200R1 antibody, in patients with advanced neuroendocrine cancers: Results from a multi-center multi-country phase 1/2a expansion cohort." Journal of Clinical Oncology 42, no. 16_suppl (June 1, 2024): 4129. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.4129.
Повний текст джерелаАнотація:
4129 Background: 23ME-00610 is being evaluated in a Phase 1/2a clinical trial in patients with advanced solid malignancies (NCT05199272) and has demonstrated an acceptable safety and tolerability profile, with favorable PK and peripheral CD200R1 saturation. Here, we report data from the neuroendocrine cancer Phase 2a expansion cohort for the first time. Methods: Eligible patients had histologically diagnosed locally advanced (unresectable) or metastatic neuroendocrine cancers who had progressed on standard therapies. Key exclusion criteria included active autoimmune disease requiring immunosuppressive therapy and Grade ≥ 3 immune-mediated toxicity related to prior immunotherapy that led to discontinuation. The primary objective was evaluation of clinical antitumor activity. Exploratory biomarkers included CD200R1 and CD200 tumor expression by IHC in archival tissue, germline genotyping, and polygenic risk score calculation for immune-mediated and cancer phenotypes. At least 15 patients were accrued to characterize target-specific biomarkers and efficacy. Patients received 1400 mg given IV every 3 weeks until disease progression, and CT/MRI scans were conducted every ~ 8 weeks. Results: Between February 23 and November 7, 2023, 16 patients with advanced neuroendocrine neoplasms (87.5% Stage IV; 62.5% NEC, 25% pancreatic, 6.3% colorectal; age: 33 to 74), who received a median of 3.5 prior treatment lines (range: 1 to 10), were enrolled and received ≥ 1 dose of 23ME-00610. Median exposure was 43.5 days (range: 1 – 212 days), and 11 patients (69%) had disease progression by the December 13, 2023 data cutoff. In the 15 efficacy evaluable patients, investigator assessed stable disease rate was 46.7% (N=7) and median progression free survival (mPFS) was 2.1 months (median potential follow-up time was 6.3 mo); 4 patients (26.7%) had durable SD > 6 mo. At least 1 treatment emergent adverse event (TEAE) was reported by all patients (N=16). Related TEAEs occurred in 8 patients (50%); all were G1/G2, and the most common were maculopapular rash (18.8%), pruritus (18.8%), nausea (12.5%), and fatigue (12.5%). Immune related TEAEs were G1 (18.8%) and included maculopapular rash (18.8%) and pruritus (12.5%). No G4/G5 or TEAEs leading to 23ME-00610 discontinuation were reported. 1400 mg dose resulted in full peripheral saturation of CD200R1 and minimal treatment-emergent ADA. Conclusions: 23ME-00610 continues to show encouraging PKPD, safety, and disease control in a subset of unselected patients with advanced neuroendocrine cancers. Exploratory biomarker data warrant additional analyses to examine the potential for biomarker stratification on disease outcomes. Phase 2a expansion trials of 23ME-00610 utilizing retrospective biomarker analysis are ongoing in multiple indications. Clinical trial information: NCT05199272 .
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Bharani, Anjali, Mohini Harshey, and Swati Raipurkar. "Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study." International Journal of Contemporary Pediatrics 5, no. 2 (February 22, 2018): 324. http://dx.doi.org/10.18203/2349-3291.ijcp20180055.
Повний текст джерелаАнотація:
Background: Children contribute a significant proportion of the tuberculosis (TB) burden in India and suffer severe TB related morbidity and mortality, particularly in endemic areas. Diagnosis and management of pediatric TB especially Extra pulmonary (EPTB) is challenging. The present study was designed to study clinical, laboratory characteristics and outcome of childhood tuberculosis.Methods: A retrospective analysis of 90 cases of TB in children within 2 year period was conducted at Pediatric Department and DOTS center at a tertiary care hospital from January 2015 to December 2016.Results: In the present study 20% of the total TB patients attending DOTS OPD were Children. Most common symptoms were Fever (53.3 %), Cough (46.6%), abdominal pain (18.8%), lymphadenopathy (13.3%), osteo-articular symptoms (13.3%), weight loss (10%), CNS related complaints like convulsions and unconsciousness (6.6%). History of contact was present in 10 cases (11%). Sputum examination was positive in 9 cases (10%) who were predominantly older children above 12 years. Mantoux test was positive in 9 cases (10%). Only one patient was HIV positive. Extra pulmonary tuberculosis (EPTB) patients were more common than pulmonary. 47 out of the 90 cases (52%) were receiving DOTS for EPTB. Out of the 90 cases 84 (93.3%) were on New Category 1 treatment and 6 (6.6%) were on Cat 2 treatment. Out of the total 90 cases 3 defaulted, 3 died, rest completed treatment with good compliance and no side-effects and were declared cured.Conclusions: In present study, it was found that extra-pulmonary tuberculosis (EPTB) patients are more common than pulmonary tuberculosis in pediatric age group. Sputum positivity yield is very low in pediatric age group. Success of treatment with DOTS is good (94.4%). No adverse effects of ATT were observed.
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Llenas-García, Jara, Philip Wikman-Jorgensen, Concepción Gil-Anguita, Violeta Ramos- Sesma, Diego Torrús-Tendero, Raquel Martínez-Goñi, Mónica Romero-Nieto, et al. "Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country." PLOS Neglected Tropical Diseases 15, no. 3 (March 24, 2021): e0009281. http://dx.doi.org/10.1371/journal.pntd.0009281.
Повний текст джерелаАнотація:
Background Chagas disease (CD) is a chronic parasitic disease caused by Trypanosoma cruzi and is endemic to continental Latin America. In Spain, the main transmission route is congenital. We aimed to assess adherence to regional recommendations of universal screening for CD during pregnancy in Latin American women in the province of Alicante from 2014 to 2018. Methodology/Principal findings Retrospective quality study using two data sources: 1) delivery records of Latin American women that gave birth in the 10 public hospitals of Alicante between January 2014 and December 2018; and 2) records of Chagas serologies carried out in those centers between May 2013 and December 2018. There were 3026 deliveries in Latin American women during the study period; 1178 (38.9%) underwent CD serology. Screening adherence ranged from 17.2% to 59.3% in the different health departments and was higher in Bolivian women (48.3%). Twenty-six deliveries (2.2%) had a positive screening; CD was confirmed in 23 (2%) deliveries of 21 women. Bolivians had the highest seroprevalence (21/112; 18.7%), followed by Colombians (1/333; 0.3%) and Ecuadorians (1/348; 0.3%). Of 21 CD-positive women (19 Bolivians, 1 Colombian, 1 Ecuadorian), infection was already known in 12 (57.1%), and 9 (42.9%) had already been treated. Only 1 of the 12 untreated women (8.3%) was treated postpartum. Follow-up started in 20 of the 23 (87.0%) neonates but was completed only in 11 (47.8%); no cases of congenital transmission were detected. Among the 1848 unscreened deliveries, we estimate 43 undiagnosed cases of CD and 1 to 2 undetected cases of congenital transmission. Conclusions/Significance Adherence to recommendations of systematic screening for CD in Latin American pregnant women in Alicante can be improved. Strategies to strengthen treatment of postpartum women and monitoring of exposed newborns are needed. Currently, there may be undetected cases of congenital transmission in our province.
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Brand, Claire L., Dan G. O’Neill, Zoe Belshaw, Camilla L. Pegram, Kim B. Stevens, and Rowena M. A. Packer. "Pandemic Puppies: Demographic Characteristics, Health and Early Life Experiences of Puppies Acquired during the 2020 Phase of the COVID-19 Pandemic in the UK." Animals 12, no. 5 (March 2, 2022): 629. http://dx.doi.org/10.3390/ani12050629.
Повний текст джерелаАнотація:
The UK recorded sharp rises in puppy purchasing during the 2020 phase of the COVID-19 pandemic, with many first-time dog owners purchasing puppies to improve their mental health during this challenging period. Government restrictions on movement and social interaction during the pandemic led to animal welfare concerns over puppies’ reduced time-sensitive exposures to key environmental and social stimuli during their critical developmental period. This study aimed to compare demographics, health and early-life experiences of puppies purchased and brought home < 16 weeks of age between 23 March–31 December 2020 (“Pandemic Puppies”), with dogs purchased and brought home < 16 weeks during the same date period in 2019 (“2019 puppies”). An online survey of UK-based puppy owners was conducted between 10 November and 31 December 2020 with valid responses representing 5517 puppies (Pandemic Puppies: n = 4369; 2019 puppies: n = 1148). Multivariable logistic regression modelling revealed that Pandemic Puppies were less likely to have attended puppy training classes (67.9% 2019 vs. 28.9% 2020; p < 0.001) or had visitors to their home (94.5% 2019 vs. 81.8% 2020; p < 0.001) aged < 16 weeks compared with 2019 puppies. Fewer Pandemic Puppies underwent veterinary checks prior to purchase than 2019 puppies (2019: 91.3% vs. 2020: 87.4%; p < 0.001), but more were sold with a passport (2019: 4.1% vs. 2020: 7.1%; p < 0.001). Pandemic Puppies were significantly more likely to be ‘Designer Crossbreeds’ (2019: 18.8% vs. 2020: 26.1%; p < 0.001) and less likely to be Kennel Club registered than 2019 puppies (2019: 58.2% vs. 2020: 46.2%; p < 0.001). Greater support from veterinary and animal behavioural professionals is likely needed to ameliorate the health and behavioural impacts of growing up in a pandemic upon this vulnerable population.
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Li, Teng-yu, Jun-sheng Chu, Yu-lun Xu, Jun Yang, James Wang, Yu-Hua Huang, Aij-Lie Kwan, and Gui-Huai Wang. "Surgical strategies and outcomes of spinal ependymomas of different lengths: analysis of 210 patients." Journal of Neurosurgery: Spine 21, no. 2 (August 2014): 249–59. http://dx.doi.org/10.3171/2014.3.spine13481.
Повний текст джерелаАнотація:
Object The aim of this study was to investigate the surgical strategies and outcomes for spinal ependymomas of different lengths. Methods The authors used data from 210 patients with spinal ependymomas (WHO Grades II and III) in this 10-year retrospective study (January 1999 to December 2008), dividing them into 3 different groups according to length (spinal ependymomas < 5 cm, 5–10 cm, and > 10 cm). All patients underwent tumor resection. The basic characteristics of the patients were reviewed and the functional status was assessed using the McCormick classification. Results There were 89, 81, and 40 patients, respectively, in the 3 groups (< 5 cm, 5–10 cm, and > 10 cm). Grosstotal resections (GTRs) were performed in 172 patients (81.9% overall, or 86.5%, 79.0%, and 77.5% in the 3 groups, respectively). Subtotal and partial resections were achieved in 38 patients (18.1%). Eight patients with medulla oblongata or upper cervical cord tumors received a tracheotomy postoperatively. The follow-up period ranged from 56 to 176 months. One hundred thirty-five patients (76.7%) experienced improvement, (88.2%, 83.8%, and 34.4% in the < 5 cm, 5–10 cm, and > 10 cm groups, respectively). Thirty-three patients (18.8%) maintained their pretreatment status, and 8 patients (4.5%) showed deterioration following tumor resection at 6 months. Tumor recurrence or progression was observed in 6 (2.9%) of the 210 patients. Among the 6 patients, recurrent tumors were located in the conus (n = 3), thoracic (n = 1), and medullocervical cord (n = 2). Conclusions Radical resection of spinal ependymomas could be performed in most patients, and the rate of GTR was significantly different in the different-length groups (< 10 cm vs > 10 cm, p = 0.032). Patients with longer tumors had worse surgical results compared with those with small tumors (p < 0.001), and more postoperative neuropathic pain and proprioceptive deficits could usually be observed in patients harboring larger tumors. Early diagnosis and timely operation are critical to achieving better neurological outcomes. For tumors with dense adhesions, complete removal should be performed cautiously because of the significant incidence of neurological deterioration.
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Heijl, Caroline, Kerstin Westman, Peter Höglund, and Aladdin J. Mohammad. "Malignancies in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis: A Population-based Cohort Study." Journal of Rheumatology 47, no. 8 (September 1, 2019): 1229–37. http://dx.doi.org/10.3899/jrheum.181438.
Повний текст джерелаАнотація:
Objective.Patients with ANCA-associated vasculitides (AAV) exhibit higher rates of malignancy than the general population. We assessed whether the cancer risk is increased in a well-characterized population-based cohort of AAV in southern Sweden, followed for a median time of 8 years.Methods.With case record review, the outcomes and malignancy development in a cohort of 195 patients with AAV [granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA] diagnosed between 1997 and 2010 were assessed. The patients were followed until death or December 31, 2015. The age- and sex-standardized incidence ratios (SIR) were estimated using the Swedish population data as a reference.Results.During the observation period of about 1500 person-years, we found 60 cancers in 52 of the 195 patients. SIR (95% CI) was 2.8 (2.1–3.6) for cancers at all sites, 1.8 (1.3–2.5) for all cancers excluding squamous cell carcinoma (SCC), 12.9 (8.4–18.8) for SCC, 4.3 (1.4–10.0) for bladder cancer, and 7.0 (1.4–20.5) for pancreatic cancer. Cumulative doses of cyclophosphamide (CYC) < 10 g were not associated with higher incidence of cancers other than SCC (SIR 1.63, 95% CI 0.8–2.9).Conclusion.In contrast to previous publications assessing malignancy risk in patients with AAV, we show in this population-based cohort of patients a persistent increased risk for overall malignancy, bladder cancer, and pancreatic cancer as well as a markedly increased risk for SCC. There was no increase in incidence of cancers other than SCC for those treated with < 10 g CYC.
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Majid, Hafsa, Muhammad Abbas Abid, Nawazish Zehra, Siraj Muneer, Lena Jafri, and Aysha Habib Khan. "PARADIGM SHIFTS IN VITAMIN D TESTING AND DIAGNOSIS: A DECADE-LONG OBSERVATIONAL STUDY." Pakistan Journal of Pathology 33, no. 1 (March 31, 2022): 1–4. http://dx.doi.org/10.55629/pakjpathol.v33i1.690.
Повний текст джерелаАнотація:
Objective: Awareness about vitamin D deficiency has linearly increased over the years. Lack of clear guidelines regarding optimum dosage and inadvertent use of higher doses can lead to toxicity. This study was done to evaluate the changes in trends of vitamin D testing and status of serum levels of 25-hydroxy vitamin D (25-OHD) submitted for analysis to a large-volume reference laboratory. Material and Methods: An observational study was conducted at the section of Chemical Pathology, Department of Pathology and Laboratory Medicine, Aga Khan University. Data analysis of serum 25-OHD tests from January 2010 to December 2019 was performed. The patients were categorized as deficient, insufficient, optimal, hypervitaminosis or toxic based on 25-OHD values. Data was analyzed using Microsoft Excel version 16. Results: Total 903,282 tests were analyzed during the 10 years’ period Mean age (SD) was 40.7 (16.5) years, with 35.8% males. The 25-OHD testing since 2010 to 2019 increased by 62.3% in adults and 66.6% in children. The mean 25-OHD levels improved from 18.8 ng/ml in 2010 to 24.5 ng/ml in 2019 in adults, while no change in mean 25-OHD levels was noted in children. Conclusion: Testing and status of vitamin D improved with increased mean vitamin D levels and a decline in deficiency over 10 years. Our study calls for developing local guidelines for vitamin D-deficiency management, and taking caution when prescribing supplements, as vitamin D intoxication is concurrently increasing in the population. Key Words: 25OHD, Deficiency, Toxicity, Pakistan.