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Waibel, Raimund, Peter Blickle, and Rudolf Schlögl. "Rezension von: Blickle, Peter; Schlögl, Rolf (Hrsg.), Die Säkularisation im Prozess der Säkularisierung Europas." Schwäbische Heimat 57, no. 3 (October 11, 2022): 355–56. http://dx.doi.org/10.53458/sh.v57i3.4116.
Повний текст джерелаАнотація:
Peter Blickle und Rolf Schlögl (Hrsg.): Die Säkularisation im Prozess der Säkularisierung Europas. (Oberschwaben – Geschichte und Kultur, Band 13). Bibliotheca academica Verlag Epfendorf 2005. 574 Seiten. Gebunden € 39,-. ISBN 3-92847-158-9
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RANA, MUKHTAR AHMED, SHAHID MANZOOR, and GUL SHER. "CHARGE AND MASS CHANGING CROSS-SECTIONS OF 158A GeV Pb PROJECTILES ON Al, Cu, Bi, AND Pb TARGETS: FRAGMENTATION PROCESSES." International Journal of Modern Physics E 19, no. 10 (October 2010): 1993–2007. http://dx.doi.org/10.1142/s0218301310016466.
Повний текст джерелаАнотація:
We report here on total and partial charge changing cross-sections of 158A GeV lead projectiles on Al , Cu , Pb and Bi stationary targets using CR-39 detectors. Present results are compared with relevant published results. Deep discussion of nuclear fragmentation processes is provided. Stacks of CR-39 Track Detectors with above-mentioned targets were exposed to 158 A GeV 207 Pb projectiles at the CERN-SPS beam facility at normal incidence with a fluence of about 1500 ions/cm 2. Lengths of etched cones on one face of the CR-39 detectors before and after the target were measured for each stack. These measurements were used for determination of total and partial charge changing cross-sections of 158 A GeV Pb 82+ projectiles on these targets in the charge region 63 < Z < 82. The charge resolution (σZ) achieved in the present experiment is ~0.18e. Mass changing cross-sections are derived from the measured charge changing cross-sections using hyper-geometric relationship. A new method is proposed for separate measurements of electromagnetic and nuclear parts of fragmentation cross-sections using ion channeling and blocking conditions of projectiles in crystalline targets.
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WILLIAMS, DAVID M., PAT A. SIMS, and JAKUB WITKOWSKI. "Notes on the diatom collection of the Natural History Museum, London (BM) V: (a) ‘Stictodiscus manillensis’ nom. nud., (b) Stictodiscus pantocsekii and ‘Stictodiscus pantocsekii var. minor’, (c) a note on the name ‘Stictodiscella’; and (d) some comments on Jósef Pantocsek’s Beiträge zur Kenntnis der Fossilen Bacillarien Ungarns." Phytotaxa 507, no. 2 (June 9, 2021): 167–74. http://dx.doi.org/10.11646/phytotaxa.507.2.4.
Повний текст джерелаАнотація:
This short paper is comprised of four notes on, or related to, the genus Stictodiscus Greville (1861a: 39) based, for the most part, on specimens in BM (Natural History Museum, London) and a correction to the type designation of Aulacodiscus madagascarensis Tempère noted in a previous publication (Williams 2021: 158)
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Nhantumbo, Aquino Albino, Charlotte Elizabeth Comé, Plácida Iliany Maholela, Alcides Moniz Munguambe, Paulino da Costa, Mariana Mott, Gabriella Rosa Cunha, et al. "Etiology of meningitis among adults in three quaternary hospitals in Mozambique, 2016–2017: The role of HIV." PLOS ONE 17, no. 5 (May 11, 2022): e0267949. http://dx.doi.org/10.1371/journal.pone.0267949.
Повний текст джерелаАнотація:
Background Meningitis remains an important cause of morbi-mortality in adults in sub-Saharan Africa. Data on the etiological investigation of meningitis in adults in Mozambique is limited and most studies were conducted in southern Mozambique. Identification of the etiology of meningitis in adults are crucial to guide prevention and treatments strategies. In this study, we determine the burden of fungal and bacterial meningitis among adults at the three largest hospitals in Mozambique. Method We performed analysis of data from the routine sentinel surveillance system for meningitis in Mozambique from January 2016 to December 2017. Cerebrospinal fluid (CSF) samples were collected from eligible adults (≥18 years old) who met World Health Organization (WHO) case definition criteria for Meningitis. All samples were tested by cryptococcal antigen (CrAg) lateral flow assay (LFA), culture and triplex real-time polymerase chain reaction (qPCR) assay and all patients were tested for human immunodeficiency virus (HIV) using the national algorithm for HIV testing. Results Retrospective analysis of 1501 CSF samples from adults clinically suspected of meningitis revealed that 10.5% (158/1501) were positive for bacterial and fungal meningitis. Of these 158 confirmed cases, the proportion of Cryptococcal meningitis and pneumococcal meningitis was38.6% (95% CI: 31.0% to 46.7%) and 36.7% (95% CI: 29.2% to 44.7%), respectively. The other bacterial agents of meningitis identified include Neisseria meningitidis (8.9%; 14/158), Escherichia coli (6.3%; 10/158), Haemophilus influenzae (5.1%; 8/158) and S. aureus (4.4%; 7/158), which represent (24.7%; 39/158) of the total confirmed cases. Conclusion Altogether, our findings show a high burden of Cryptococcal meningitis among adults in Mozambique, especially in people living with HIV, followed by pneumococcal meningitis. Our findings suggest that rollout of CrAg Lateral Flow Assay in the health system in Mozambique for early detection of cryptococcus neoformans is necessary to improve overall patient care.
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Calvo, Jorge H., Magdalena Serrano, Flavie Tortereau, Pilar Sarto, Laura P. Iguacel, María A. Jiménez, José Folch, José L. Alabart, Stéphane Fabre, and Belén Lahoz. "Development of a SNP parentage assignment panel in some North-Eastern Spanish meat sheep breeds." Spanish Journal of Agricultural Research 18, no. 4 (October 27, 2020): e0406. http://dx.doi.org/10.5424/sjar/2020184-16805.
Повний текст джерелаАнотація:
Aim of study: To validate two existing single nucleotide polymorphism (SNP) panels for parentage assignment in sheep, and develop a cost effective genotyping system to use in some North-Eastern Spanish meat sheep populations for accurate pedigree assignment.Area of study: SpainMaterial and methods: Nine sheep breeds were sampled: Rasa Aragonesa (n=38), Navarra (n=39), Ansotana (n=41), Xisqueta (n=41), Churra Tensina (n=38), Maellana (39), Roya Bilbilitana (n=24), Ojinegra (n=36) and Cartera (n=39), and these animals were genotyped with the Illumina OvineSNP50 BeadChip array. Genotypes were extracted from the sets of 249 SNPs and 163 SNPs for parentage assignment designed in France and North America, respectively. Validation of a selected cost-effective genotyping panel of 158 SNPs from the French panel were performed by Kompetitive allele specific PCR (KASP). Additionally, some functional SNPs (n=15) were also genotyped.Main results: The set of 249 SNPs for parentage assignment showed better diversity, probability of identity, and exclusion probabilities than the set of 163 SNPs. The average minor allele frequency for the set of 249, 163 and 158 SNPs were 0.41 + 0.01, 0.39 + 0.01 and 0.42 + 0.01, respectively. The parentage assignment rate was highly dependent to the percentage of putative sires genotyped.Research highlights: The described method is a cost-effective genotyping system combining the genotyping of SNPs for the parentage assignment with some functional SNPs, which was successfully used in some Spanish meat sheep breeds.
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Elmaagacli, Ahmet H., Hellmut Ottinger, Koldehoff Michael, Peceny Rudolf, Nina K. Steckel, Rudolf Trenschel, Harald Biersack, Hans Grosse-Wilde, Michael Flasshove, and Dietrich W. Beelen. "Reduced Risk of Residual Molecular and Hematological Relapse in Patients with Cml after KIRir-Ligand Mismatched Hematpoietic Stem Cell Transplantation." Blood 104, no. 11 (November 16, 2004): 974. http://dx.doi.org/10.1182/blood.v104.11.974.974.
Повний текст джерелаАнотація:
Abstract We compared the incidence of molecular and hematological relapse in 236 CML patients (pts) after HLA-identical (n=158) [group 1], HLA class I antigen mismatched and KIR-ligand compatible (n=49) [group 2], and HLA class I antigen mismatched and KIR-ligand incompatible (n=29) [group 3] hematopoietic stem cell transplantation. In group 1 133/158 (84%) pts were in first chronic phase of CML, the corresponding figures were 33/49 (67%) pts in group 2, and 19/29 (64%) in group 3 (p<0.05). Accordingly, 25/158 (16%) pts in group 1, 16/49 (33%) pts in group 2, and 10/29 (34%) pts in group 3 were in advanced disease phases of CML (accelerated phase, 2nd chronic phase, or blastic phase). Stem cell grafts were from sibling donors in 97% of pts in group 1, 37% of pts in group 2, and in 59% of pts in group 3 (p<0.01 group 1 versus groups 2+3). Median age and gender constellations were not different between the three groups (age medians between 37–41 years, range 16–63). Acute GVHD grade 2–4 occurred in 62/158 (39%) pts in group 1, in 24/49 (49%) pts in group 2, and in 15/29 (52%) pts in group 3 (NS). Estimates of chronic GVHD did not differ significantly between the study groups with 94% + 2% in group 1, 95% + 4% in group 2, and 91% ± 6% in group 3. Molecular relapse as detected by real-time RT-PCR occurred in 1/29 (3%) pts of group 3 compared to 62/158 (39%) of pts in group 1, and in 11/49 (22%) pts in group 2 (p<0.001). A hematological relapse developed in 20/158 (13%) pts in group 1, in 2/49 (4%) pts in group 2 and in 0/29 (0%) pts in group 3 (p<0.05). Multivariate analysis on the risk molecular relapse included possible influencial covariates like disease stage, age (> 40 years or < 40 years), gender matching of donor and recipient, occurrence of acute and chronic GVHD, HLA matching between donor and recipient, donor source [sibling or unrelated], and graft type [bone marrow or PBSCs]. This analysis confirmed that KIR-mismatches are a strong independent predictor for the occurrence of bcr-abl transcripts after transplantation (p<0.02). The 8-year overall survival estimates were not different between the three groups (67% group 1, 52% group 2 66% group 3). In conclusion, KIR-ligand incompatibility is an important prognostic factor for the occurrence of molecular and hematological relapse after allogeneic transplantation for CML.
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Ivanković, Damir, Erica Barbazza, Véronique Bos, Óscar Brito Fernandes, Kendall Jamieson Gilmore, Tessa Jansen, Pinar Kara, et al. "Features Constituting Actionable COVID-19 Dashboards: Descriptive Assessment and Expert Appraisal of 158 Public Web-Based COVID-19 Dashboards." Journal of Medical Internet Research 23, no. 2 (February 24, 2021): e25682. http://dx.doi.org/10.2196/25682.
Повний текст джерелаАнотація:
Background Since the outbreak of COVID-19, the development of dashboards as dynamic, visual tools for communicating COVID-19 data has surged worldwide. Dashboards can inform decision-making and support behavior change. To do so, they must be actionable. The features that constitute an actionable dashboard in the context of the COVID-19 pandemic have not been rigorously assessed. Objective The aim of this study is to explore the characteristics of public web-based COVID-19 dashboards by assessing their purpose and users (“why”), content and data (“what”), and analyses and displays (“how” they communicate COVID-19 data), and ultimately to appraise the common features of highly actionable dashboards. Methods We conducted a descriptive assessment and scoring using nominal group technique with an international panel of experts (n=17) on a global sample of COVID-19 dashboards in July 2020. The sequence of steps included multimethod sampling of dashboards; development and piloting of an assessment tool; data extraction and an initial round of actionability scoring; a workshop based on a preliminary analysis of the results; and reconsideration of actionability scores followed by joint determination of common features of highly actionable dashboards. We used descriptive statistics and thematic analysis to explore the findings by research question. Results A total of 158 dashboards from 53 countries were assessed. Dashboards were predominately developed by government authorities (100/158, 63.0%) and were national (93/158, 58.9%) in scope. We found that only 20 of the 158 dashboards (12.7%) stated both their primary purpose and intended audience. Nearly all dashboards reported epidemiological indicators (155/158, 98.1%), followed by health system management indicators (85/158, 53.8%), whereas indicators on social and economic impact and behavioral insights were the least reported (7/158, 4.4% and 2/158, 1.3%, respectively). Approximately a quarter of the dashboards (39/158, 24.7%) did not report their data sources. The dashboards predominately reported time trends and disaggregated data by two geographic levels and by age and sex. The dashboards used an average of 2.2 types of displays (SD 0.86); these were mostly graphs and maps, followed by tables. To support data interpretation, color-coding was common (93/158, 89.4%), although only one-fifth of the dashboards (31/158, 19.6%) included text explaining the quality and meaning of the data. In total, 20/158 dashboards (12.7%) were appraised as highly actionable, and seven common features were identified between them. Actionable COVID-19 dashboards (1) know their audience and information needs; (2) manage the type, volume, and flow of displayed information; (3) report data sources and methods clearly; (4) link time trends to policy decisions; (5) provide data that are “close to home”; (6) break down the population into relevant subgroups; and (7) use storytelling and visual cues. Conclusions COVID-19 dashboards are diverse in the why, what, and how by which they communicate insights on the pandemic and support data-driven decision-making. To leverage their full potential, dashboard developers should consider adopting the seven actionability features identified.
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Abass, Elfadil M., Durria Mansour, Mohamed el Mutasim, Muna Hussein та Abdallah el Harith. "β-Mercaptoethanol-modified ELISA for diagnosis of visceral leishmaniasis". Journal of Medical Microbiology 55, № 9 (1 вересня 2006): 1193–96. http://dx.doi.org/10.1099/jmm.0.46643-0.
Повний текст джерелаАнотація:
Following antigen preparation procedures similar to those of the direct agglutination test (DAT), an IgG ELISA employing intact β-mercaptoethanol (β-ME)-treated Leishmania donovani promastigotes was developed. The performance of the β-ME ELISA thus developed was assessed in patients with confirmed visceral leishmaniasis (VL), revealing slightly lower sensitivity (39/40=97.5 %) than that of the DAT (40/40=100 %). When challenged with sera of individuals with non-VL conditions, including leukaemia and African trypanosomiasis, the specificity of the β-ME ELISA was 100 % (158/158), compared to 98.8 % (156/158) for DAT. In an endemic population (n=145) manifesting a clinical suspicion of VL, results obtained with the β-ME ELISA were highly concordant with those of DAT, both in the seropositive (65/68=95.6 %) and seronegative (77/80=96.3 %) groups. Furthermore, the incorporated intact antigen demonstrated higher sensitivity in ELISA (16/18=88.9 %) than the water-soluble equivalent (13/18=72.2 %). The stability of the formaldehyde-fixed antigen (2 months at 4 °C) in β-ME ELISA, as well as the option for direct testing of whole-blood samples and visual reading of results (within 2 h, compared to 18 h for DAT), advocate the simultaneous application of the technique with DAT for confirmation of VL in laboratories with limited facilities.
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Godoy, Ilda de, Suzana Erico Tanni, Liana Sousa Coelho, Rosana dos Santos e. Silva Martin, Luciana Cristina Parenti, Luiz Mauro Andrade, and Irma Godoy. "Programa de cessação de tabagismo como ferramenta para o diagnóstico precoce de doença pulmonar obstrutiva crônica." Jornal Brasileiro de Pneumologia 33, no. 3 (June 2007): 282–86. http://dx.doi.org/10.1590/s1806-37132007000300009.
Повний текст джерелаАнотація:
OBJETIVO: A doença pulmonar obstrutiva crônica (DPOC) é subdiagnosticada e subtratada, o que resulta em subestimação do impacto da doença. O objetivo deste estudo foi avaliar se a inclusão da espirometria na avaliação dos fumantes que ingressam em programas de cessação do tabagismo contribui para o diagnóstico precoce da DPOC. MÉTODOS: Análise retrospectiva de dados médicos de 158 fumantes atendidos no programa cessação de tabagismo (Faculdade de Medicina de Botucatu, São Paulo, Brasil), de janeiro 2003 a novembro 2005. Todos os indivíduos tinham mais de 40 anos (idade média: 55 ± 8,5 anos), sendo 99 (62,6%) do sexo feminino. Foram analisados os dados clínicos, os diagnósticos médicos prévios e os resultados da espirometria. RESULTADOS: Dos 158 fumantes avaliados, 57 (36,1%) indivíduos preenchiam os critérios diagnósticos para DPOC e 14 (8,9%) foram considerados em risco para o desenvolvimento da doença. Dos 57 que preenchiam os critérios diagnósticos para DPOC, 39 (68,4%) foram diagnósticos novos e 18 (31,6%) foram confirmação de diagnóstico prévio da doença. Entre os 18 com diagnóstico anterior, 10 (56%) tinham doença leve/moderada e 8 (44%) doença grave. Sete pacientes com diagnóstico anterior de DPOC apresentaram resultados de função de pulmonar não compatíveis com os critérios diagnósticos da doença. Entre os 39 novos diagnósticos, 38 (97,4%) eram de doença leve/moderada e apenas 1 (2,6%) tinha DPOC grave CONCLUSÃO: A inclusão da espirometria na avaliação inicial dos fumantes admitidos em programa de cessação de tabagismo pode ser uma ferramenta útil para o diagnóstico precoce da DPOC.
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Nicòtina, P. A., A. Zanghì, and G. Catone. "Uterine Malignant Mixed Mü llerian Tumor (Metaplasic Carcinoma) in the Cat: Clinicopathologic Features and Proliferation Indices." Veterinary Pathology 39, no. 1 (January 2002): 158–60. http://dx.doi.org/10.1354/vp.39-1-158.
Повний текст джерела
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Bhujel, Sapana, Rakshya Khadka, Swechhya Baskota, Lisasha Poudel, Suman Bista, Minani Gurung, Tamanna Neupane, and Bikram Adhikari. "Knowledge and Practice of Complementary Feeding among the Mothers of the Child Aged Group 6-24 Months, Tanahu Distirct, Nepal." Journal of Nepal Health Research Council 19, no. 1 (April 23, 2021): 127–34. http://dx.doi.org/10.33314/jnhrc.v19i1.3371.
Повний текст джерелаАнотація:
Background: Early and late introduction of complementary feeding is associated with increased morbidity and nutritional deficiencies in children. In 2016, the under 5 mortality rate of Nepal was 39 deaths per 1000 live births and around 1 million under 5 children had suffered from chronic malnutrition. The main aim of this study was to identify the level of knowledge and practice regarding complementary feeding among the mothers of children aged group 6 to 24 months in Bhanu Municipality, Tanahu District, Nepal.Methods: A descriptive cross-sectional study was conducted with 158 mothers of children age group 6 to 24 months from ward number 1 and 2 in Bhanu Municipality, Tanahu District, Nepal. Data collection was done after taking ethical approvalby using a semi-structured questionnaire via face-to-face interviews. Collected data were entered and descriptive analysis was carriedout in Statistical Package for the Social Services version 20. Categorical variables were presented using frequency and percentage. Clopper-pearson method was used to determine 95% confidence interval.Results: Out of 158 respondents, 26.6% (95%CI:19.9,34.2) had inadequate knowledge, whereas 73.4% (95%CI:65.8, 80.1) had adequate knowledge on complementary feeding. Likewise, the study revealed that 51.9%(95%CI: 43.8, 59.9) did the right practice, while 48.1%(95%CI: 40.1,56.2) were involved in the wrong practice on complementary feeding. Only 39 % mothers gained the knowledge about complementary feeding from the health workers. 2.5% of mother had exclusively breastfed their child up to just 3 months. Conclusions: Despite the good level of knowledge about complementary feeding, the wrong practice was prevalent in about half of the mothers. As a result, enhancing existing strategies and developing new intervention measures including capacity building of healthworkers to improve child feeding practices must be mandatory actions for the government and policymakers.Keywords: Complementary feeding; knowledge; Nepal; practice
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Riddler, Sharon A., Jennifer E. Balkus, Urvi M. Parikh, John W. Mellors, Carolyne Akello, Sufia Dadabhai, Felix Mhlanga, et al. "Clinical and Virologic Outcomes Following Initiation of Antiretroviral Therapy Among Seroconverters in the Microbicide Trials Network-020 Phase III Trial of the Dapivirine Vaginal Ring." Clinical Infectious Diseases 69, no. 3 (October 22, 2018): 523–29. http://dx.doi.org/10.1093/cid/ciy909.
Повний текст джерелаАнотація:
Abstract Background A vaginal ring containing dapivirine, a non-nucleoside human immunodeficiency virus (HIV)-1 reverse transcriptase inhibitor (NNRTI), was safe and effective in preventing HIV-1 infection in African women. We examined the impact of dapivirine ring use at the time of HIV-1 acquisition on subsequent HIV-1 disease progression and responses to NNRTI-containing antiretroviral therapy (ART). Methods HIV-1 disease progression and virologic failure following initiation of ART were assessed among women who acquired HIV-1 while participating in Microbicide Trials Network–020, a randomized, placebo-controlled trial of a monthly, dapivirine vaginal ring. Results Among the 158 participants who acquired HIV-1 (65 dapivirine, 93 placebo), no differences between dapivirine and placebo participants were observed in CD4+ cell counts or plasma HIV-1 RNA over the first year after infection (prior to ART). During follow-up, 100/158 (63%) participants initiated NNRTI-containing ART (dapivirine: 39/65; placebo: 61/93); the median time to HIV-1 RNA <200 copies/ml was approximately 90 days for both dapivirine and placebo ring recipients (log-rank P = .40). Among the 81 participants with at least 6 months of post-ART follow-up, 19 (24%) experienced virologic failure (dapivirine: 6/32, 19%; placebo: 13/39, 27%; P = .42). Conclusions The acquisition of HIV-1 infection during dapivirine or placebo treatment in ASPIRE did not lead to differences in HIV-1 disease progression. After the initiation of NNRTI-containing ART, dapivirine and placebo participants had similar times to virologic suppression and risks of virologic failure. These results provide reassurance that NNRTI-based ART regimens are effective among women who acquired HIV-1 while receiving the dapivirine vaginal ring. Clinical Trials Registration NCT016170096 and NCT00514098.
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Arokiaraj, L. Anand, and T. R. Gobinaath. "Prevalence and risk factors for bronchial asthma in an urban area of Puducherry: a cross-sectional study." International Journal of Contemporary Pediatrics 5, no. 6 (October 22, 2018): 2249. http://dx.doi.org/10.18203/2349-3291.ijcp20184290.
Повний текст джерелаАнотація:
Background: Food allergy is mostly IgE-mediated which is estimated to affect 6% to 8% children and 3% to 4% adults the clinical and social impact of which takes a hard toll in early childhood. The objective of this study is to study the magnitude of food allergy and differences in food allergens among the urban and rural school-going children.Methods: A cross-sectional study was conducted among 350 school going children, aged 5-10 years, attending to two private schools (n=192) and two government schools (n=158) in the urban and rural field practice areas respectively and data regarding food allergens was collected using a semi-structured proforma.Results: There was a significant higher (p<0.001) proportion of wheeze symptomatics among the urban (n=70, 44.3%) than the rural students (n=37, 19.3%). The students had higher allergies to Ice-cream (14.57%, n=51), prawn (11.14%, n=39), peanut (14.57%, n=51), garlic (14.57%, n=51), fish (11.14%, n=39) and milk (11.14%, n=39).Conclusions: There was a higher proportion of food allergy among the urban school students compared to the rural students. The food allergens also varied significantly in their influence on food allergy among the urban and rural areas.
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Gobinaath, T. R., and L. Anand Arokiaraj. "Food allergy and allergens associated with bronchial asthma among school children in an urban and rural area of Puducherry, India: a cross-sectional study." International Journal of Contemporary Pediatrics 5, no. 4 (June 22, 2018): 1623. http://dx.doi.org/10.18203/2349-3291.ijcp20182577.
Повний текст джерелаАнотація:
Background: Food allergy is mostly IgE-mediated which is estimated to affect 6% to 8% children and 3% to 4% adults the clinical and social impact of which takes a hard toll in early childhood. The objective is to study the magnitude of food allergy and differences in food allergens among the urban and rural school-going children.Methods: A cross-sectional study was conducted among 350 school going children, aged 5-10 years, attending to two private schools (n=192) and two government schools (n=158) in the urban and rural field practice areas respectively and data regarding food allergens was collected using a semi-structured proforma.Results: There was a significant higher (p<0.001) proportion of wheeze symptomatics among the urban (n=70, 44.3%) than the rural students (n=37, 19.3%). The students had higher allergies to Ice-cream (14.57%, n=51), prawn (11.14%, n=39), peanut (14.57%, n=51), garlic (14.57%, n=51), fish (11.14%, n=39) and milk (11.14%, n=39).Conclusions: There was a higher proportion of food allergy among the urban school students compared to the rural students. The food allergens also varied significantly in their influence on food allergy among the urban and rural areas.
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Кириллов, Николай Александрович, Владимир Михайлович Изместьев та Екатерина Алексеевна Соколова. "Сравнительная оценка урожайности зеленой массы гибридов кукурузы". Аграрная Россия, № 5 (3 червня 2018): 9–11. http://dx.doi.org/10.30906/1999-5636-2018-5-9-11.
Повний текст джерелаАнотація:
В кормовом отношении кукуруза составляет основу рациона молочного скота. В результате исследований, проведенных в 2015 – 2016 гг. в Марий Эл, выявлено, что в агроклиматических условиях республики можно с успехом возделывать раннеспелые гибриды кукурузы воронежской селекции в кормовых целях. Опыты проводили в трехкратной повторности при систематическом расположении делянок и норме высева семян 80 тыс. шт./га на дерново-подзолистых, среднесуглинистых почвах. Гибрид кукурузы Каскад 166 АСВ (контрольный вариант) на момент учета урожая сформировал 51,7 т зеленой массы с гектара. Из 11 изучаемых гибридов кукурузы гибриды ВТГ 185-15, ВТГ 189-15, Воронежский 197 СВ, ВТГ 193 А-15 и Воронежский 158 СВ по сбору зеленой массы превзошли контрольный вариант на 0,8 – 17,3 т/га. Урожайность зеленой массы кукурузы оказалась наивысшей в 2015 г. и составила 46 – 59 т/га против 25 – 39 т/га в 2016 г. Наибольшая урожайность зеленой массы в 2015 г. зафиксирована у гибрида кукурузы Воронежский 158 СВ (69 т/га), в 2016 г. — у гибрида кукурузы ВТГ 189-15 (39,2 т/га). Урожайность зеленой массы на 2-й год исследований оказалась значительно ниже по сравнению с 2015 г., что можно объяснить неблагоприятными погодными условиями сезона. Полное отсутствие осадков и недостаток влаги в начале вегетационного периода способствовали торможению ростовых процессов и накоплению органического вещества в растениях.
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Griffin, Nathan, Mark Marsland, Severine Roselli, Christopher Oldmeadow, John Attia, Marjorie M. Walker, Hubert Hondermarck, and Sam Faulkner. "The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer." Biomolecules 10, no. 9 (September 17, 2020): 1329. http://dx.doi.org/10.3390/biom10091329.
Повний текст джерелаАнотація:
The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear. In this study, TrkA expression was assessed via immunohistochemistry of 158 invasive ductal carcinomas (IDC), 158 invasive lobular carcinomas (ILC) and 50 ductal carcinomas in situ (DCIS). TrkA was expressed in cancer epithelial and myoepithelial cells, with higher levels of TrkA positively associated with IDC (39% of cases) (p < 0.0001). Interestingly, TrkA was significantly increased in tumours expressing the human epidermal growth factor receptor-2 (HER2), with expression in 49% of HER2-positive compared to 25% of HER2-negative tumours (p = 0.0027). A panel of breast cancer cells were used to confirm TrkA protein expression, demonstrating higher levels of TrkA (total and phosphorylated) in HER2-positive cell lines. Functional investigations using four different HER2-positive breast cancer cell lines indicated that the Trk tyrosine kinase inhibitor GNF-5837 reduced cell viability, through decreased phospho-TrkA (Tyr490) and downstream AKT (Ser473) activation, but did not display synergy with Herceptin. Overall, these data highlight a relationship between the tyrosine kinase receptors TrkA and HER2 and suggest the potential of TrkA as a novel or adjunct target for HER2-positive breast tumours.
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Workman, John B., Patrick E. McCullough, F. Clint Waltz, James T. Brosnan, and Gerald M. Henry. "Perennial Ryegrass and Tall Fescue Reseeding Intervals after Aminocyclopyrachlor Application." HortScience 47, no. 6 (June 2012): 798–800. http://dx.doi.org/10.21273/hortsci.47.6.798.
Повний текст джерелаАнотація:
Turfgrass managers applying aminocyclopyrachlor for annual and perennial broadleaf weed control in cool-season turfgrasses may want to reseed into treated areas. Field experiments were conducted in Georgia), Tennessee, and Texas to investigate perennial ryegrass (Lolium perenne L.) and tall fescue (Festuca arundinacea Schreb.) reseeding intervals after aminocyclopyrachlor applications. Perennial ryegrass and tall fescue establishment were similar to the non-treated control after treatments of aminocyclopyrachlor and 2,4-dichlorophenoxyacetic acid (2,4-D) + dicamba + methylchlorophenoxypropionic acid (MCPP) at 0, 2, 4, or 6 weeks before seeding. Results demonstrate that no reseeding interval is required after aminocyclopyrachlor treatment. Perennial ryegrass and tall fescue can be safely seeded immediately after aminocyclopyrachlor treatment at 39, 79, and 158 g/a.i./ha.
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Weng, Wen-Kai, Sandra J. Horning, Robert S. Negrin, and Ronald Levy. "Immunoglobulin G Fc Polymorphism Is Correlated with Rituximab-Induced Neutropenia Following Autologous Hematopoietic Cell Transplantation." Blood 104, no. 11 (November 16, 2004): 442. http://dx.doi.org/10.1182/blood.v104.11.442.442.
Повний текст джерелаАнотація:
Abstract Rituximab has been given following autologous hematopoietic cell transplantation (HCT) for recurrent or refractory B cell lymphoma with the goal of eradicating minimal residual disease. Our recent study showed that this is a feasible strategy although transient grade 3 or 4 neutropenia was observed in 51% of patients (Blood 103:777, 2004). We also reported that two IgG Fc receptor (FcγR) polymorphisms, FcγRIIIa 158 V/V and FcγRIIa 131 H/H genotypes, predict response to rituximab therapy in patients with follicular lymphoma, probably due to their role in the antibody-dependent cellular cytotoxicity (ADCC) (JCO 21:3940, 2003). In the current report, we correlated FcγR polymorphisms with clinical outcomes after post-transplant rituximab. A total of 35 patients with diffuse large cell (25 patients), mantle cell (3 patients), transformed (3 patients) or other (4 patients) subtypes of B cell lymphoma received high-dose therapy, autologous HCT and rituximab, administrated as 4-weekly infusions (375 mg/m2) starting around day 42 and 6 months after HCT. Genomic DNA was available for FcγR polymorphism analysis in 33 cases. For the FcγRIIIa polymorphism, 4 (12%) patients were homozygous valine/valine (158 V/V), 14 (42%) patients were heterozygous valine/phenylalanine (158 V/F) and 15 (46%) patients were homozygous phenylalanine/phenylalanine (158 F/F). For the FcγRIIa polymorphism, 8 (24%) patients were homozygous histidine/histidine (131 H/H), 16 (49%) patients were heterozygous histidine/arginine (131 H/R) and 9 (27%) patients were homozygous arginine/arginine (131 R/R). We did not find a correlation of either the FcγRIIIa V/F polymorphism or the FcγRIIa H/R polymorphism with time to relapse after HCT. But the small number of relapses limited our power. Although rituximab infusions were well tolerated in this group of patients, 32% of the treatment courses in this study were associated with rituximab-induced grade 3 or grade 4 neutropenia (ANC < 1000/μl), which was recorded in 51% of patients. These neutropenic episodes were not associated with infection and responded well to G-CSF treatment. The reason for this high incidence of rituximab-induced neutropenia is unclear. Among the 33 patients analyzed for FcγR polymorphisms, FcγRIIIa 158 V/V homozygotes experienced relatively greater neutropenia (V/V : 3/4, 75%; V/F: 8/14, 57%; F/F: 5/15, 33%). For the 57 treatment courses, the FcγRIIIa 158 V/V genotype was associated with a greater chance of rituximab-induced neutropenia, compared to F carriers (158 V/F and 158 F/F). The incidence of rituximab-induced neutropenia was 71% for V/V, 39% for V/F, 19% for F/F and 28% for F carriers (V/V vs F carriers, p = 0.035). In contrast, the FcγRIIa H/R polymorphism had no impact on rituximab-induced neutropenia. Although the mechanism of rituximab-induced neutropenia is unknown, this report implicates an FcγR-mediated process, such as ADCC. It is possible that B cell depletion by rituximab affects either directly or indirectly cytokine (e.g. G-CSF) production as a mechanism for neutropenia. It will be of great interest to study the correlation between FcγR polymorphisms and the prevalence and duration of B cell depletion after rituximab therapy in larger clinical studies both after HCT and in conjunction with other myelosupressive therapies.
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Galanello, R., E. Dessi, MA Melis, M. Addis, MA Sanna, C. Rosatelli, F. Argiolu, N. Giagu, MP Turco, and E. Cacace. "Molecular analysis of beta zero-thalassemia intermedia in Sardinia." Blood 74, no. 2 (August 1, 1989): 823–27. http://dx.doi.org/10.1182/blood.v74.2.823.823.
Повний текст джерелаАнотація:
Abstract In this study we have carried out alpha- and beta-globin gene analysis and defined the beta-globin gene polymorphisms in a group of patients with thalassemia intermedia of Sardinian descent. A group of patients (109) with thalassemia major of the same origin served as control. Characterization of the beta-thalassemia mutation showed either a frameshift mutation at codon 6 or a codon 39 nonsense mutation. We found that homozygotes for the frameshift mutation at codon 6 or compound heterozygotes for this mutation and for the codon 39 nonsense mutation develop thalassemia intermedia more frequently than thalassemia major. The frameshift mutation at codon 6 was associated with haplotype IX that contains the C-T change at position -158 5′ to the G gamma globin gene implicated in high gamma chain production and thus the mild phenotype. In patients' homozygotes for codon 39 nonsense mutation, those with thalassemia intermedia more frequently had the two- gene deletion form of alpha-thalassemia, or functional loss of the alpha 2 gene as compared with those with thalassemia major. In a few siblings with thalassemia major and intermedia, the thalassemia intermedia syndrome correlated with the presence of the -alpha/-alpha genotype. No cause for the mild phenotype was detected in the majority of patients who had not inherited either haplotype IX or alpha- thalassemia.
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Galanello, R., E. Dessi, MA Melis, M. Addis, MA Sanna, C. Rosatelli, F. Argiolu, N. Giagu, MP Turco, and E. Cacace. "Molecular analysis of beta zero-thalassemia intermedia in Sardinia." Blood 74, no. 2 (August 1, 1989): 823–27. http://dx.doi.org/10.1182/blood.v74.2.823.bloodjournal742823.
Повний текст джерелаАнотація:
In this study we have carried out alpha- and beta-globin gene analysis and defined the beta-globin gene polymorphisms in a group of patients with thalassemia intermedia of Sardinian descent. A group of patients (109) with thalassemia major of the same origin served as control. Characterization of the beta-thalassemia mutation showed either a frameshift mutation at codon 6 or a codon 39 nonsense mutation. We found that homozygotes for the frameshift mutation at codon 6 or compound heterozygotes for this mutation and for the codon 39 nonsense mutation develop thalassemia intermedia more frequently than thalassemia major. The frameshift mutation at codon 6 was associated with haplotype IX that contains the C-T change at position -158 5′ to the G gamma globin gene implicated in high gamma chain production and thus the mild phenotype. In patients' homozygotes for codon 39 nonsense mutation, those with thalassemia intermedia more frequently had the two- gene deletion form of alpha-thalassemia, or functional loss of the alpha 2 gene as compared with those with thalassemia major. In a few siblings with thalassemia major and intermedia, the thalassemia intermedia syndrome correlated with the presence of the -alpha/-alpha genotype. No cause for the mild phenotype was detected in the majority of patients who had not inherited either haplotype IX or alpha- thalassemia.
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Copaja Corzo, Cesar, and Luis A. Céspedes Hernández. "Percepción del uso de dióxido de cloro y grado de conocimiento sobre la COVID-19 en estudiantes de Medicina de una universidad peruana." Revista Médica Basadrina 15, no. 1 (March 4, 2021): 03–10. http://dx.doi.org/10.33326/26176068.2021.1.1027.
Повний текст джерелаАнотація:
Objetivo: Determinar la percepción del uso de dióxido de cloro (CDS) y el grado de conocimiento sobre la COVID-19 en estudiantes de Medicina de una universidad peruana. Material y métodos: Estudio observacional de corte transversal. Se realizó una encuesta virtual a 158 estudiantes de Medicina de la Universidad Nacional Jorge Basadre Grohmann, del 15 al 18 de agosto del 2020. El instrumento utilizado se dividió en tres secciones: características sociodemográficas, nivel de conocimientos sobre la COVID-19 y actitudes frente al uso del CDS. El análisis bivariado se realizó utilizando la prueba exacta de Fisher. Resultados: De los 158 estudiantes de Medicina encuestados, el 53 % fueron mujeres, la edad media fue de 21 (RIC: 19-23) años. El 22 % considera que si un médico o personal de salud recomienda el uso de dióxido de cloro, es porque tiene alguna utilidad para tratar la COVID-19, y el 39 % tiene un conocimiento bajo sobre la enfermedad. Existe diferencia entre la percepción frente al uso de dióxido de cloro y el nivel de conocimientos sobre la COVID-19 (p<0,05). Conclusión: Casi un cuarto de los estudiantes considera útil el uso de dióxido de cloro para tratar la COVID-19 si lo recomienda un médico o si la terapia médica convencional no surtiera efecto. Lo mencionado puede deberse a un nivel de conocimiento bajo sobre la enfermedad.
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Agustina, Sri, Johanes Singoreto Widjaja, Riska Puspasari, and Dika Chandra. "Studi Pasien Stroke Iskemik dengan Terapi Antiplatelet di Poliklinik Saraf Rumah Sakit Tingkat III Brawijaya Surabaya, Indonesia, Agustus–November 2022." Cermin Dunia Kedokteran 50, no. 8 (August 2, 2023): 410–13. http://dx.doi.org/10.55175/cdk.v50i8.998.
Повний текст джерелаАнотація:
Latar Belakang. Acetosal dan clopidogrel merupakan agen antiplatelet yang sering digunakan dalam pencegahan stroke iskemik. Tujuan. Mengetahui kejadian rekurensi stroke iskemik dengan terapi antiplatelet di poliklinik saraf Rumah Sakit Tingkat III Brawijaya Surabaya. Metode. Penelitian cross-sectional deskriptif non-eksperimental. Data rekam medis pasien stroke iskemik dengan terapi antiplatelet periode Agustus – November tahun 2022 di Rumah Sakit Tingkat III Brawijaya Surabaya. Hasil. Didapatkan 245 pasien stroke iskemik, di mana 146 pasien (59,59%) adalah laki-laki, 140 pasien (57%) dalam rentang usia 19-64 tahun, 158 pasien (64,49%) dengan hipertensi, 80 pasien (32,65%) dengan diabetes melitus, dan 39 pasien (15,92%) dengan jantung. Politerapi kombinasi acetosal dan clopidogrel pada 5 pasien (1,6%), monoterapi antiplatelet pada 240 pasien, 123 pasien (50,2%) menggunakan acetosal. Pasien stroke pertama sebanyak 96,3%. Simpulan. Penderita stroke iskemik terutama pada laki-laki usia 19-64 tahun dengan penyakit komorbid terbanyak adalah hipertensi. Jenis obat terbanyak adalah monoterapi acetosal. Kejadian rekurensi jarang. Introduction. Acetosal and clopidogrel are antiplatelet agents often used for ischemic stroke prevention. Objective. To observe stroke recurrence among ischemic stroke patients with antiplatelet therapy at Neurology Clinic in Brawijaya level III Hospital Surabaya, Indonesia. Methods. A cross-sectional descriptive non-experimental research on data from medical records of ischemic stroke patients with antiplatelet therapy during August-November 2022 in Tingkat III Brawijaya Hospital, Surabaya, Indonesia. Result. During the survey period, 245 ischemic stroke patients were recorded, 146 patients (59,59%) were male, and 140 patients (57%) aged between 19-64 year-old. Hypertension was found in 158 patients (64.49%), 80 patients (32.65%) with diabetes mellitus, and 39 patients (15.92%) with heart disease. Acetosal and clopidogrel combination was used by 5 patients (1.6%). The majority of 240 patients (98,3%) used monotherapy, whereas 123 patients used acetosal (51,2%). A proportion of 96.3% were first stroke patients. Conclusion. Most ischemic stroke patients are male, aged 19-64 year-old with hypertension as the most common comorbidity. The majority used acetosal monotherapy. Recurrent strokes are rare.
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Vaverniece, Ieva, Indra Majore-Dusele, Bonnie Meekums, and Oskars Rasnacs. "Erratum to: “Dance movement therapy for obese women with emotional eating: A controlled pilot study” [Arts Psychother. 39 (2) (2012) 87-158]." Arts in Psychotherapy 39, no. 2 (April 2012): 161. http://dx.doi.org/10.1016/j.aip.2012.04.006.
Повний текст джерела
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Mysnyk, Kateryna. "Institutional Conditions for the Development of the System of Economic Investigations at Enterprises." Herald of the Economic Sciences of Ukraine, no. 2(39) (2020): 158–65. http://dx.doi.org/10.37405/1729-7206.2020.2(39).158-165.
Повний текст джерелаАнотація:
At present, there is a need to find new mechanisms for conducting economic investigations in the field of economic activity of enterprises and the introduction of effective methods of control, which can significantly reduce the risk of financial and economic crimes. The purpose of this study is to substantiate and develop proposals for the creation of appropriate institutional conditions for the development of the system of economic investigations in enterprises. To achieve this goal, methods of analysis and synthesis, comparison, generalization, statistical analysis, expert survey, structural and logical analysis were used. The article analyzes and generalizes scientific approaches to defining the essence and content of the concept of “forensic”. On the basis of expert surveys of international companies, the peculiarities of forensics as a method of economic investigations at Ukrainian enterprises have been identified. A statistical analysis of the main indicators of administrative offenses in Ukraine has been performed. To ensure the development of the system of economic investigations at enterprises, it is proposed to create appropriate institutional conditions, namely: at the legislative level to define the essence of the concept of “forensics as a method of economic investigations in the field of economic activity”, its principles, features, legal, organizational and financial principles of regulating development in enterprises; to form an appropriate institutional environment, i.e institutions that would control and regulate the process of economic investigations. For example, legislative work is currently under way to establish the Bureau of Financial Investigations as the central executive body that implements state policy to prevent, detect, stop, investigate and detect criminal offenses in the field of economic activity that directly or indirectly harm the public interest. in the field of finance. That is, it is planned to create a single body in which to investigate all economic crimes against the state; to form an integrated structure of interaction between financial institutions and central executive bodies for the organization of forensics at enterprises of various types of economic activity and organizational and legal forms of ownership; to develop an organizational and economic mechanism for managing the development of the system of economic investigations at enterprises; to develop the mechanism of information support of development of system of economic investigations at the enterprises with use of digital technologies.
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Bäz, Laura, Marisa Puscholt, Claudia Lasch, Mahmoud Diab, Sven Möbius-Winkler, P. Christian Schulze, Gudrun Dannberg, and Marcus Franz. "Delayed Improvement of Depression and Anxiety after Transcatheter Aortic Valve Implantation (TAVI) in Stages of Extended Extra-Valvular Cardiac Damage." Journal of Clinical Medicine 10, no. 8 (April 8, 2021): 1579. http://dx.doi.org/10.3390/jcm10081579.
Повний текст джерелаАнотація:
Background: Depression and anxiety are frequently occurring and likely to be linked to the severity of cardiac diseases like aortic stenosis (AS). This seems to be of interest since a staging classification of extra-valvular cardiac damage in AS has been introduced and shown to be of prognostic relevance. Objective: The current study aimed to investigate the frequency of depression and anxiety in association to staging and their dynamics after transcatheter aortic valve implantation (TAVI). Methods: A total number of 224 AS patients undergoing TAVI were classified according to the 2017 staging classification into stage 0 to 4 and further dichotomized into group A (stage 0 to 2) and B (stage 3 and 4). Using the Hospital Anxiety and Depression Scale (HADS-D), patients were assigned to depressive versus non-depressive or anxious versus non-anxious per staging group respectively, and analyzed at baseline, 6 weeks, 6 months and 12 months after TAVI. Results: After dichotomization, 158 patients (70.5%) were assigned to group A and 66 patients (29.5%) to group B. The part showing pathologic values for depression was 25.4% (57/224 patients) in the entire collective, 26.6% (42/158 patients) in group A and 22.7% (15/66 patients) in group B (p = n.s.). The proportion showing pathologic values for anxiety was 26.8% (60/224 patients) in the entire collective and did not differ between group A (24.7%, 39/158 patients) and B (31.8%, 21/66 patients) (p = n.s.). In patients revealing pathologic values for depression or anxiety prior to TAVI, there were significant and stable improvements over time observable already in short-term (6 weeks) follow-up in group A, and likewise, but later, in long-term (6/12 months) follow-up in group B. Conclusions: Although of proven prognostic relevance, higher stages of extra-valvular cardiac damage are not associated with higher rates of pre-existing depression or anxiety. The TAVI procedure resulted in a persisting reduction of depression and anxiety in patients showing pathologic values at baseline. Notably, these improvements are timely delayed in higher stages.
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Zhang, W., M. Gordon, A. M. Schultheis, F. Nagashima, M. Azuma, D. Yang, S. Iqbal, and H. Lenz. "Two immunoglobulin G fragment C receptor polymorphisms associated with clinical outcome of EGFR-expressing metastatic colorectal cancer patients treated with single agent cetuximab." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 3028. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.3028.
Повний текст джерелаАнотація:
3028 Background: Cetuximab is a chimeric immunoglobulin G1 anti-EGFR monoclonal antibody with efficacy in metastatic colorectal cancer patients refractory to irinotican chemotherapy. Recent studies show that Antibody-dependent cellular cytotoxicity (ADCC) mediated through Fc receptors plays an important role in the antitumor effect of IgG1 antibody. There are three classes of FcγRs involved in the regulation of ADCC. FcγRIIa(CD32) and FcγRIIIa(CD16) activates and FcγRIIb inhibits activation. Clinical studies show FcγRIIIa 158 V/F polymorphism was associated with tumor response and progression-free survival in the follicular lymphoma patients treated with rituximab as first line treatment. Also, a H/R polymorphism at position 131 of FcγRIIa has been found to affects its affinity to human IgG and independently predict response to Rituximab. Since Cetuximab and Rituximab belong to the same chimeric IgG1 monoclonal antibody, we test hypothesis whether these two FcγR polymorphisms associated with clinical outcome in colorectal cancer patients treated with single agent Cetuximab. Methods: we tested both FcγRIIIa 158 V/F and FcγRIIa 131 H/R gene polymorphisms using PCR-RFLP method in genomic DNA extracted from peripheral blood from 39 EGFR-expressing metastatic colorectal cancer patients enrolled in a phase II single agent Cetuximab treatment clinical trial (IMCL-0144). Results: We found patients with FcγRIIa 131 HH or HR genotype show better time to progression and overall survival compare to patients with R/R genotype (p=0.037, p=0.22, respectively, log-rank test). Also, there is trend significance in tumor response when we compare patients with RR genotype and patients with HH or HR genotype (p=0.08, fisher’s exact test). FcγRIIIa 158 V/F also show trend significance in tumor response (p=0.067, fisher’s exact test). Conclusions: These data suggest Two Immunoglobulin G Fragment C Receptor polymorphismsFcγRIIIa158V/F andFcγRIIa 131 H/R may be potential molecular markers for clinical outcome of refractory metastatic colorectal caner patients treated with single agent EGFR inhibitor Cetuximab. Prospective studies are needed to confirm these preliminary findings. [Table: see text]
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Könen, Tanja, and Julia Karbach. "Self-Reported Cognitive Failures in Everyday Life: A Closer Look at Their Relation to Personality and Cognitive Performance." Assessment 27, no. 5 (July 11, 2018): 982–95. http://dx.doi.org/10.1177/1073191118786800.
Повний текст джерелаАнотація:
A recent review concluded that the Cognitive Failures Questionnaire is the most widely used instrument to assess cognitive failures. Our aims were to place cognitive failures self-reported with the Cognitive Failures Questionnaire into their nomological network by conceptually replicating known relations to the Big Five and by extending this knowledge through testing their relations with latent cognitive abilities (Study 1, N = 158, age 20-86 years) and theoretically relevant Big Five subfacets (Study 2, N = 176, age 19-39 years). Cognitive failures were unrelated to objective cognitive performance (processing speed, memory, and inhibition), but reliably related to the personality domains conscientiousness, neuroticism, and almost all their subfacets. Thus, self-reported cognitive failures do not qualify as a proxy for objective cognitive performance tasks. They are rather useful as illustration of behavioral manifestations related to personality domains.
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Takahashi, D., and H. Funahashi. "43 WARMING TEMPERATURE AFFECTS THE VIABILITY AND MEIOTIC COMPETENCE OF IMMATURE PORCINE OOCYTES VITRIFIED IN A CHEMICALLY DEFINED SOLUTION." Reproduction, Fertility and Development 26, no. 1 (2014): 135. http://dx.doi.org/10.1071/rdv26n1ab43.
Повний текст джерелаАнотація:
The aim of this study was to examine the viability and meiotic competence of porcine oocytes when immature porcine cumulus-oocyte complexes (COC) were pretreated for vitrification at different temperatures (25 and 39°C), vitrified in a chemically defined solution, and warmed at different temperatures (39 and 60°C). Cumulus-oocyte complexes were aspirated from middle-size follicles (3–6 mm in diameter) of abattoir-derived porcine ovaries. After collection, the COC were pretreated with cryoprotectants at different temperatures (25 and 39°C) and vitrified in a serum-free chemically defined solution containing 0.6 mg mL–1 of hydroxypropyl cellulose, basically according to a commercial protocol (Cryotop, Kitazato BioPharma Co. Ltd., Fuji, Japan). The vitrified COC were warmed in 1 M trehalose solution at 39 for 60 s or at 60°C for 30 s. The COC were cultured for in vitro maturation (IVM) in modified porcine oocyte medium (POM) supplemented with 50 μM β-mercaptoethanol, 10 IU mL–1 of eCG, 10 IU mL–1 of hCG, and 1 mM dibutyryl cyclic AMP (dbcAMP) for 20 h and then in the fresh medium without hormonal supplements and dbcAMP for another 24 h. Viability of COC was evaluated under fluorescent microscopy after stain with fluorescein diacetate and propidium iodide. Nuclear maturation of the oocytes was evaluated after 44 h of IVM. Statistical analyses of results from 5 replicated trials were performed by ANOVA with a Bonferroni/Dunn post-hoc test (significance, P < 0.05). Although viabilities of vitrified oocytes after 44 h of IVM [6.0% (9/149) to 37.8% (59/155)] were significantly lower than fresh controls [98.8% (158/160)], the viabilities of vitrified oocytes warmed at 60°C [32.0% (49/160) to 37.8% (59/155)] were significantly higher than those warmed at 39°C [6.0% (9/149) to 10.0% (16/160)]. Maturation rates in vitrified oocytes [2.7% (4/149) to 19.8% (31/155)] were also significantly lower than fresh controls [74.8% (120/160)]. Regardless of temperature during pretreatment for vitrification (25 and 39°C), maturation rate of the oocytes warmed at 60°C after vitrification [16.4% (25/154) to 19.8% (31/155)] was significantly higher than that warmed at 39°C [3.1% (5/160) to 2.7% (4/149)]. In conclusion, these results demonstrate that warming at 60°C for 30 s maintains the viability and meiotic competence of immature porcine COC.
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Kántor, Tibor, Bianca Grigorescu, Gabriel Popescu, Attila Ferencz, Örs Nagy, János Jung, and István Gergely. "Traumás asphyxia maradandó látásvesztéssel." Orvosi Hetilap 158, no. 22 (June 2017): 864–68. http://dx.doi.org/10.1556/650.2017.30750.
Повний текст джерелаАнотація:
Abstract: Traumatic asphyxia is a rare condition that occurs after compressive thoracoabdominal trauma, which is characterized by subconjunctival hemorrhage, cervicofacial cyanosis, edema and petechiae. Serious life-threatening thoracic and abdominal injuries may coexist. After conservatory treatment in most cases complete recovery is achieved, but in isolated cases permanent neurological lesions may occur. We present the case of the 39-year-old male patient who suffered a compressive thoracoabdominal trauma. The physical examination showed the characteristic “ecchymotic mask”. After surgical treatment of the abdominal injuries and intensive therapy the patient was discharged with permanent vision loss. The high retrograde venous pressure in the head and neck may be associated with neuronal ischemia, which can lead to irreversible optic nerve atrophy. It is therefore important to carry out an early, routine and complete ophtalmologic examination, especially in the intubated and poorly cooperative patients. Orv Hetil. 2017; 158(22): 864–868.
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Pope, David A. "An Analysis of the Repertoire Performed by Youth Orchestras in the United States." String Research Journal 9, no. 1 (June 25, 2019): 35–49. http://dx.doi.org/10.1177/1948499219851378.
Повний текст джерелаАнотація:
The purpose of this study was to develop a deeper understanding of repertoire performed by youth orchestras in the United States. Through an online survey, youth orchestra administrators ( N = 39) provided information about repertoire performed by their program’s premier orchestra during their 2015-2016 season. Orchestras performed 302 different pieces of music by 158 different composers. The Firebird by Igor Stravinsky, Carmen Suite No. 1 by Georges Bizet, and Ruslan and Ludmilla Overture by Mikhail Glinka were performed most frequently. Approximately three quarters of all compositions were written after 1850, and only 7.14% were composed after 2000. Compositions by Tchaikovsky, Dvorak, and Brahms were the most frequently performed, and female composers only wrote 0.78% of the repertoire performed by youth orchestras during their 2015-2016 season. Conductors should use these findings as an impetus to identify culturally diverse repertoire appropriate for youth orchestras by non-male composers.
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Muddin, M. Hikam. "ANALISA PENGENDALIAN KUALITAS PRODUK PREFORM PADA MESIN INJECTION MOULDING." Journal Mechanical and Manufacture Technology (JMMT) 4, no. 1 (May 9, 2023): 18–25. http://dx.doi.org/10.35891/jmmt.v4i1.3812.
Повний текст джерелаАнотація:
PT. MAS merupakan perusahaan yang bergerak dibidang air minum dalam kemasan dengan produk yang dihasilkan menggunakan kemasan botol. Bagian injection moulding adalah bagian proses awal pembuatan kemasan botol yang digunakan untuk produk air minuman. Permasalahan yang terjadi bagaimana standar kualitas produk preform di perusahaan, Apa saja defect produk preform yang ditemukan, dan bagaimana perhitungan Cp Cpk produk Preform. Tujuan dari penelitian ini adalah untuk mengetahui standar kualitas produk Preform, untuk mengetahui persentase produk Preform, dan menganalisa nilai Cp Cpk produk Preform. hasil pengamatan dapat diketahui total produk defect sebanyak 158 pcs dan didominasi oleh defect yellow sebanyak 96 pcs dengan persentase 60,8%. Kemudian disusul defect short shot sebanyak 39 pcs dengan persentase 24,7% dan terakhir ada defect inject point length sebanyak 23 pcs dengan persentase 14,5%. Hasil defect tersebut secara keseluruhan disebabkan oleh faktor manusia dimana terdapat kesalahan prosedur kerja dan kurangnya kesadaran akan kebersihan lingkungan kerja.
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Bosch, AN, and MC Kirkman. "Maintenance of hyperglycaemia does not improve perfomence in a 100 km cycling time trial." South African Journal of Sports Medicine 19, no. 3 (October 5, 2007): 94. http://dx.doi.org/10.17159/2078-516x/2007/v19i3a262.
Повний текст джерелаАнотація:
Objectives. The aim of this study was to determine whether the elevated plasma glucose oxidation rate (~ 1.8 g.min-1) in the latter stages of prolonged exercise in subjects in which hyperglycaemia (± 10 mmol.l-1) is maintained via a glucose clamp, improves 100 km cycling time-trial (TT) performance. Design. Seven endurance-trained male cyclists (22±4 yrs) participated in this randomised crossover trial. On two occasions, separated by 7 - 10 days, subjects performed a self-paced TT in the laboratory. During one TT blood glucose was maintained at a euglycaemic concentration of ± 5 mmol.l-1 (ETT) and during the other, at ±10 mmol.l-1 (HTT). Each TT was interspersed with 5 X 1 km high-intensity periods (HIP) and 4 X 4 km HIP, in an attempt to mimic the variable intensity of competitive road races. Subjects were instructed to complete the TT in the ‘fastest time possible', taking the 9 HIP (21 km) into consideration. Results. There were no significant differences between ETT and HTT in overall time (143:09±7:14 v. 142:23±7:16 min:s), mean power (275±39 v. 279±39 W) and heart rate (160±9 v. 158±11 beats.min-1). Conclusion. Time trial performance over 100 km is not improved by maintaining a hyperglycaemic (10 mmol.l-1) blood glucose concentration. South African Journal of Sports Medicine Vol. 19 (3) 2007: pp. 94-98
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Kantarjian, Hagop, Jorge Cortes, Dong-Wook Kim, Pedro Dorlhiac-Llacer, Ricardo Pasquini, John DiPersio, Martin C. Müller, et al. "Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up." Blood 113, no. 25 (June 18, 2009): 6322–29. http://dx.doi.org/10.1182/blood-2008-11-186817.
Повний текст джерелаАнотація:
Abstract Dasatinib is the most potent BCR-ABL inhibitor, with 325-fold higher potency than imatinib against unmutated BCR-ABL in vitro. Studies have demonstrated the benefits of dasatinib 70 mg twice daily in patients with accelerated-phase chronic myeloid leukemia intolerant or resistant to imatinib. A phase 3 study compared the efficacy and safety of dasatinib 140 mg once daily with the current twice-daily regimen. Here, results from the subgroup with accelerated-phase chronic myeloid leukemia (n = 317) with a median follow-up of 15 months (treatment duration, 0.03-31.15 months) are reported. Among patients randomized to once-daily (n = 158) or twice-daily (n = 159) treatment, rates of major hematologic and cytogenetic responses were comparable (major hematologic response, 66% vs 68%; major cytogenetic response, 39% vs 43%, respectively). Estimated progression-free survival rates at 24 months were 51% and 55%, whereas overall survival rates were 63% versus 72%. Once-daily treatment was associated with an improved safety profile. In particular, significantly fewer patients in the once-daily group experienced a pleural effusion (all grades, 20% vs 39% P < .001). These results demonstrate that dasatinib 140 mg once daily has similar efficacy to dasatinib 70 mg twice daily but with an improved safety profile. This trial is registered at www.clinicaltrials.gov as #CA180-035.
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Downie, I. P., and B. T. Evans. "Re: Holmes S, Hutchison I. Reconstruction of the orbital floor after its removal for malignancy. Br J Oral Maxillofac Surg 2001; 39: 158–159." British Journal of Oral and Maxillofacial Surgery 39, no. 6 (December 2001): 485. http://dx.doi.org/10.1054/bjom.2001.0679.
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Stover, Angela M., Sydney Henson, Allison Mary Deal, Carrie Tompkins Stricker, Karen Joan Hammelef, Antonia Vickery Bennett, Philip M. Carr, et al. "Methods for alerting clinicians to concerning symptom questionnaire responses during cancer care: Approaches from two randomized trials (STAR, AFT-39 PRO-TECT)." Journal of Clinical Oncology 36, no. 30_suppl (October 20, 2018): 158. http://dx.doi.org/10.1200/jco.2018.36.30_suppl.158.
Повний текст джерелаАнотація:
158 Background: There is limited research on methods for alerting clinicians to concerning patient-reported outcome (PRO) responses and how often PROs trigger alerts to nurses during cancer care. Methods: In two randomized trials, adults with advanced cancer receiving chemotherapy were enrolled. Participants were randomized to usual care vs. weekly PROs completed between visits (with automated feedback to nurses). PRO responses in the intervention arm triggered automated email alerts to nurses for frequent, severe, or worsening symptoms in the last 7 days. Alert thresholds for PROs were chosen a priori but were unique to each study. The “Symptom Tracking and Reporting” (STAR) trial was conducted at one academic medical center. The “PROs to Enhance Cancer Treatment” (PRO-TECT [AFT-39]) cluster-randomized trial is being conducted in > 30 community practices. Results: In STAR, 766 patients participated (58% female, 38% ages ≥65, 17% minority, 28% ≤high school). 441 participants were randomized to the intervention arm, where 1,431/84,212 items (2%) triggered a concerning symptom alert, during 1,070/8,498 weeks (13%). Frequent alerts were for fatigue (62%), pain (32%), and appetite (16%). In PRO-TECT (AFT-39), 300 patients have been enrolled (58% female, 49% ages ≥65, 8% minority, 47% ≤high school) out of 1,000. 146 participants have been randomized to the intervention arm, where 1,422/24,739 items (6%) triggered an alert, during 824/2249 weeks (37%). Common alerts were for pain (48%), physical function (35%), and diarrhea (15%). PRO-TECT provided clinical decision support with alerts. Conclusions: In two randomized trials in advanced cancer, PROs collected during care delivery enabled tailored treatment based on issues identified on PROs. Pain, physical function, appetite, and diarrhea commonly triggered alerts for concerning symptoms. Early PRO-TECT results are showing a trend for higher weekly alert rates for concerning symptoms (37% vs. 13% in STAR), which may indicate that the PRO intervention will be even more effective in community practices. Results assist in addressing logistical considerations for implementing PROs into routine care. Clinical trial information: NCT03249090.
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Gyenes, Andrea, Nóra Szentmáry, Gábor Tóth, Huba Kiss, Csaba Szekrényesi, Achim Langenbucher, and Zoltán Zsolt Nagy. "Crosslinking kezelés hatása a szaruhártya hámosodására." Orvosi Hetilap 158, no. 10 (March 2017): 376–79. http://dx.doi.org/10.1556/650.2017.30669.
Повний текст джерелаАнотація:
Abstract: Introduction and aim: To analyse the effect of crosslinking (CXL) on corneal epithelial healing. Patients and method: 39 keratoconus patients following CXL and 11 patients following PRK were enrolled in this study. 21, 45 and 69 hours after CXL and 16, 37 and 61 hours following PRK slitlamp photographs were taken using fluorescein staining and the size of the epithelial defect and the time of epithelial closure was determined. As the observation time-points differed in both groups, the size of the epithelial defect following PRK was calculated for the time points used for analysis of CXL patients. These data were compared using chi-quadrat test. Results: Following crosslinking, epithelial closure occured within 3, following PRK within 4 days. In the area of epithelial erosion 45 and 69 hours after CXL or PRK treatment statistically significant difference (p = 0.005 and p<0.001) was verified. Conclusion: Our results show beneficial effect of crosslinking on corneal epithelial healing. Orv. Hetil., 2017, 158(10), 376–379.
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Sinkó, János. "Antibiotikumokkal szemben ellenálló Gram-negatív baktériumok okozta súlyos fertőzések a klinikus szemével. A Birodalom visszavág?" Orvosi Hetilap 158, no. 39 (October 2017): 1528–34. http://dx.doi.org/10.1556/650.2017.30858.
Повний текст джерелаАнотація:
Abstract: In our days, growing incidence of antibiotic resistant bacteria has become an eminent public health problem. For survival Gram-negative species possess several different tools to withstand antibiotics: they produce degrading and modifying enzymes, decrease their permeability or expel drug molecules. An increasing proportion of severe nosocomial infections are caused by strains resistant to several antimicrobials (multiresistant, extensively resistant or panresistant species). Development of new antibiotic compounds may serve as a possible solution to this problem. Ceftolozane-tazobactam is a new beta-lactam+beta-lactamase-inhibitor combination resistant to most extended spectrum beta-lactamase enzymes showing excellent anti-Pseudomonas activity. It is also effective against strains when beta-lactam resistance is related to porin loss or efflux pump activity. The spectrum of ceftazidime-avibactam also includes carbapenemase-(KPC)-producing Enterobacteriaceae. In addition to novel therapy, an effective infection control system together with the prudent use of antimicrobials (antimicrobial stewardship) is of paramount importance. Orv Hetil. 2017; 158(39): 1528–1534.
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Vasquez, Ignacio, Julio Retamales, Barbara Parra, Vimbai Machimbirike, James Robeson, and Javier Santander. "Comparative Genomics of a Polyvalent Escherichia-Salmonella Phage fp01 and In Silico Analysis of Its Receptor Binding Protein and Conserved Enterobacteriaceae Phage Receptor." Viruses 15, no. 2 (January 28, 2023): 379. http://dx.doi.org/10.3390/v15020379.
Повний текст джерелаАнотація:
The polyvalent bacteriophage fp01, isolated from wastewater in Valparaiso, Chile, was described to have lytic activity across bacterial species, including Escherichia coli and Salmonella enterica serovars. Due to its polyvalent nature, the bacteriophage fp01 has potential applications in the biomedical, food and agricultural industries. Also, fundamental aspects of polyvalent bacteriophage biology are unknown. In this study, we sequenced and described the complete genome of the polyvalent phage fp01 (MH745368.2) using long- (MinION, Nanopore) and short-reads (MiSeq, Illumina) sequencing. The bacteriophage fp01 genome has 109,515 bp, double-stranded DNA with an average G+C content of 39%, and 158 coding sequences (CDSs). Phage fp01 has genes with high similarity to Escherichia coli, Salmonella enterica, and Shigella sp. phages. Phylogenetic analyses indicated that the phage fp01 is a new Tequintavirus fp01 specie. Receptor binding protein gp108 was identified as potentially responsible for fp01 polyvalent characteristics, which binds to conserved amino acid regions of the FhuA receptor of Enterobacteriaceae.
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Ardiansyah, Ardiansyah, Sahrani Sahrani, and Dinda Izzati. "Arabic Interference in Manuscript of Hadza Kitab Mujarrobat: A Study of Arabic Philology and Sociolinguistics." Arabiyatuna: Jurnal Bahasa Arab 8, no. 1 (May 27, 2024): 347. http://dx.doi.org/10.29240/jba.v8i1.9496.
Повний текст джерелаАнотація:
This research aims to describe the manuscript of the Hadza Kitab Mujarrobat and reveal the form of Arabic interference found in the manuscript of the Mujarrobat. This research uses a descriptive mix methode with two analysis tools, namely philology and sociolinguistics. This study uses Weinreich's interference theory which applies three types of interference. The Hadza Kitab Mujarrobat manuscript uses Malay Pegon Arabic script printed in 1317 AH. There are several holes caused by termites, and it uses simple illumination and has a colophon. The use of Arabic interference in the manuscript of the Hadza Kitab Mujarobat in the form of prayers (141 times), propositions (7 times), names (39 times), opening words (5 times), subtitles (48 times) and expressions Islamic (33 times). Meanwhile, the use of interference from Arabic lingual elements in the manuscript of the Hadza Kitab Mujarobat uses the form of Arabic paragraphs (41 times), Arabic sentences (118 times), Arabic phrases (158 times), and Arabic words (93 times).
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Žárský, Filip, and Jana Kočí. "Effects of nutritional interventions on well-being." Acta Salus Vitae 9, no. 1 (August 12, 2021): 67–75. http://dx.doi.org/10.58743/asv2021vol9no21.251.
Повний текст джерелаАнотація:
This study focuses on the effects of nutrition and nutritional interventions on life satistaction in the general population. The primary aim of presented study was to confirm whether and how nutrition impacts life satisfaction. The study employed an online questionnaire and to investigate people’s experiences and opinions regarding their diet and nutritional interventions and its impact on their psychological well-being. Results showed that most respondents who have experience with nutritional intervention felt an effect on their psychological feeling. Results showed that 108 respondents out of 158 were aged between 18 and 27, which is 68% of the total. 61 % of respondents were female and 39% of respondents were male The results showed that 94% of respondents were actively interested in nutrition and healthy diet, and over 89% of respondents believed that healthy diet can positively impact psychological well-being and decrease stress. However, 78% of respondents also held the view that healthy diet remains underappreciated to this day.
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Torbina, I. V. "Winter wheat of the VIR collection in the Middle Cis-Ural region." IOP Conference Series: Earth and Environmental Science 1010, no. 1 (April 1, 2022): 012017. http://dx.doi.org/10.1088/1755-1315/1010/1/012017.
Повний текст джерелаАнотація:
Abstract The aim of the study was to identify the sources of economically useful traits of winter wheat from the collection of the Federal State Budgetary Scientific Institution “Federal Research Center All-Russian Institute of Plant Genetic Resources N.I. Vavilov ”(VIR) for adaptive breeding of this crop in the Middle Cis-Ural region. Highly productive varieties Harvard (k-66051 USA), Rasad (k-66087 Kazakhstan), Augusta (k-63929 Rostov region), Dominanta (k-64620 Rostov region) and AC Buteo (k-66054 Canada) were the most adaptive according to the method of L.A. Zhivotkova, Z.A. Morozova, L.I. Sekatueva (1994). But they were characterized by significant yield variability (V=36-130 %). Varieties Nastya (k-65675 Stavropol), WA007970 (k-66043 USA), AC Buteo, PA8769-158 (k-65943 USA), Ransom (k-65236 USA) and Farnum (k-65944 USA) showed high homeostaticity (Hom = 1.8-24.7). These varieties were the most productive and stable also according to the method of E.D. Nettevich, A.I. Morgunova, M.I. Maksimenko (1985). Varieties AC Buteo (6), WA007970 (15), PA8769-158 (16), Farnum (21), Ransom (21), Nastya (22) were distinguished by the sum of ranks; the sum of the ranks of the standard Moskovskaya 39 was 22. Sources of increased grain size (weight of 1000 grains 41.2-54.0 g) were identified - varieties Nemchinovskaya 17 (k-65756), Harvard, Rasad, Nureke (k-66088), Alija (k-66089), Avesta (k- 64491), Agra (k-64492), Shestopalivka (k-65060); grain content of a ear (30.9-47.3 pcs.) - Dzhangal (k-65610), Slavitsa (k-65656), Nastya, Alija. High grain glassiness of 90-100% for two years of study (2019-2020) was obtained in varieties Nastya, Farnum, WA007970, AC Buteo and Ransom.
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Peiper, Nicholas C., Camille Gourdet, Angélica Meinhofer, Amanda Reiman, and Nicco Reggente. "Medical Decision-Making Processes and Online Behaviors Among Cannabis Dispensary Staff." Substance Abuse: Research and Treatment 11 (January 1, 2017): 117822181772551. http://dx.doi.org/10.1177/1178221817725515.
Повний текст джерелаАнотація:
Background: Most cannabis patients engage with dispensary staff, like budtenders, for medical advice on cannabis. Yet, little is known about these interactions and how the characteristics of budtenders affect these interactions. This study investigated demographics, workplace characteristics, medical decision-making, and online behaviors among a sample of budtenders. Methods: Between June and September 2016, a cross-sectional Internet survey was administered to budtenders in the San Francisco Bay Area and Greater Los Angeles. A total of 158 budtenders fully responded to the survey. A series of comparisons were conducted to determine differences between trained and untrained budtenders. Results: Among the 158 budtenders, 56% had received formal training to become a budtender. Several demographic differences were found between trained and untrained budtenders. For workplace characteristics, trained budtenders were more likely to report budtender as their primary job (74% vs 53%), practice more than 5 years (34% vs 11%), and receive sales commission (57% vs 16%). Trained budtenders were significantly less likely to perceive medical decision-making as very important (47% vs 68%) and have a patient-centered philosophy (77% vs 89%). Although trained budtenders had significantly lower Internet usage, they were significantly more likely to exchange information with patients through e-mail (58% vs 39%), text message (46% vs 30%), mobile app (33% vs 11%), video call (26% vs 3%), and social media (51% vs 23%). Conclusions: Budtenders who are formally trained exhibit significantly different patterns of interaction with medical cannabis patients. Future studies will use multivariate methods to better determine which factors independently influence interactions and how budtenders operate after the introduction of regulations under the newly passed Proposition 64 that permits recreational cannabis use in California.
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Jänsch, Sarah, Dimitar Evdokimov, Nadine Egenolf, Caren Meyer zu Altenschildesche, Luisa Kreß, and Nurcan Üçeyler. "Distinguishing fibromyalgia syndrome from small fiber neuropathy: a clinical guide." PAIN Reports 9, no. 1 (January 2024): e1136. http://dx.doi.org/10.1097/pr9.0000000000001136.
Повний текст джерелаАнотація:
Abstract Introduction: Fibromyalgia syndrome (FMS) and small fiber neuropathy (SFN) are distinct pain conditions that share commonalities and may be challenging as for differential diagnosis. Objective: To comprehensively investigate clinical characteristics of women with FMS and SFN to determine clinically applicable parameters for differentiation. Methods: We retrospectively analyzed medical records of 158 women with FMS and 53 with SFN focusing on pain-specific medical and family history, accompanying symptoms, additional diseases, and treatment. We investigated data obtained using standardized pain, depression, and anxiety questionnaires. We further analyzed test results and findings obtained in standardized small fiber tests. Results: FMS patients were on average ten years younger at symptom onset, described higher pain intensities requiring frequent change of pharmaceutics, and reported generalized pain compared to SFN. Pain in FMS was accompanied by irritable bowel or sleep disturbances, and in SFN by paresthesias, numbness, and impaired glucose metabolism (P < 0.01 each). Family history was informative for chronic pain and affective disorders in FMS (P < 0.001) and for neurological disorders in SFN patients (P < 0.001). Small fiber pathology in terms of skin denervation and/or thermal sensory threshold elevation was present in 110/158 (69.7 %) FMS patients and 39/53 (73.6 %) SFN patients. FMS patients mainly showed proximally reduced skin innervation and higher corneal nerve branch densities (p<0.001) whereas SFN patients were characterized by reduced cold detection and prolonged electrical A-delta conduction latencies (P < 0.05). Conclusions: Our data show that FMS and SFN differ substantially. Detailed pain, drug and family history, investigating blood glucose metabolism, and applying differential small fiber tests may help to improve diagnostic differentiation and targeted therapy.
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Palennari, Muhiddin, Firdaus Daud, and Nurhayati B. "Hubungan Antara Self Regulated Learning dengan Self Efficacy Mahasiswa melalui Strategi Blended Learning pada Perkuliahan Biologi Dasar." Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam 10, no. 2 (December 4, 2021): 172. http://dx.doi.org/10.35580/sainsmat102262232021.
Повний текст джерелаАнотація:
Self regulated learning merupakan suatu kemandirian yang harus ditumbuhkan agar mahasiswa tidak hanya tergantung pada informasi yang berasal dari dosen. Sedangkan, Self efficacy merupakan keyakinan dan harapan mengenai kemampuan individu untuk menghadapi tugasnya. Keduanya dapat ditumbuhkan dengan menerapkan strategi pembelajaran yang tepat. Salah satu strategi pembelajaran yang dapat diterapkan adalah strategi blended learning. Oleh karena itu, dilakukan penelitian dengan tujuan untuk mengetahui hubungan antara self regulated learning dengan self efficacy mahasiswa pada Jurusan Biologi. Populasi dalam penelitian ini adalah seluruh mahasiswa Jurusan Biologi angkatan tahun 2019 yang terdiri atas 158 orang. Sampel diambil secara acak sederhana yang terdiri atas 39 orang. Instrumen yang digunakan adalah angket self regulated learning yang terdiri atas 30 item dan angket self efficacy yang terdiri dari 18 item. Data penelitian dianalisis dengan menggunakan korelasi product moment. Hasil penelitian diperoleh nilar r = 0,619 dengan nilai signifikansi p = 0.000 lebih kecil dari α = 0,05. Dengan demikian disimpulkan bahwa ada hubungan antara self regulated learning dengan self efficacy mahasiswa pada perkuliahan Biologi Dasar. Dari hasil penelitian tersebut, self regulated learning dan self efficacy mahasiswa sebaiknya ditumbuhkembangkan dalam pembelajaran. Kata-kata kunci: self regulated learning, self efficacy, blended learningSelf-regulated learning is an independence in learning that must be promoted in order that students do not only rely solely on the information provided by lecturers. While, Self efficacy is a belief and hope regarding the ability of individuals to deal with their duties. Both can can be promoted by implementing appropriate learning strategies. One of the learnings strategies that can be implemented is the blended learning strategy. Accordingly, this research is conducted to assess the relationship between self regulated learning and student self-efficacy in the Department of Biology. The population in this study was all students of the Department of Biology in 2019 consisting of 158 people. The sample was taken by simple random sampling consisting of 39 people. The instrument used was a self regulated learning questionnaire consisting of 30 items, and a self-efficacy questionnaire consisting of 18 items. The research data was analyzed product moment correlation. The results obtained by value r = 0.619 with a significance value of p = 0.000 smaller than α = 0.05. Thus, it was concluded there was a relationship between self regulated learning and student self-efficacy in Basic Biology Class. From the results of the study, students' self-regulated learning and self-efficacy should be developed in learning.Keywords: self regulated learning, self efficacy, blended learnin
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Torrie, J., A. A. Hill, and S. Streat. "Staged Abdominal Repair in Critical Illness." Anaesthesia and Intensive Care 24, no. 3 (June 1996): 368–74. http://dx.doi.org/10.1177/0310057x9602400312.
Повний текст джерелаАнотація:
Marlex mesh interposition as part of staged abdominal repair (M-STAR) was used on 68 occasions to reduce pressure during abdominal closure (46), facilitate multiple laparotomies (15), both indications (4) or defect repair (3), in 66 critical care admissions (median \APACHE-II=21). Physiological data before and after M-STAR performed for intra-abdominal pressure were retrospectively available on 33/36 ventilated occasions. Compliance improved (median Vt/[Paw-PEEP] 22.6 vs 30.3 ml/cm H2O, P<0.0001), but efficiency of oxygenation (median PaO2/FiO2 136 vs 175 mmHg) and ventilation (median VE/PaCO2 243 vs 289 ml/min/mmHg) were unchanged. Heart rate fell (median 130 to 110, P=0.01), blood pressure and inotrope dose did not change. Urine flow increased (median 60 to 110 ml/h, P=0.007) but there was no clear trend in six-hourly serum creatinine. Seven bowel fistulae and three dehiscences occurred. Thirty-five patients survived critical care after 2–7 (median 2) M-STAR related operations and 3–63 (median 20) days. Thirty-one hospital survivors used 19–158 (median 47) hospital days; one patient was still in hospital at 39 months. Five patients died 1–55 months after hospital discharge. At follow-up 1–39 (median 7.5) months after critical care there were two fistulae, five stitch sinuses and five incisional hernias in the 27 survivors. M-STAR facilitates critical care and repeat laparotomy with acceptable surgical sequelae.
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Jiménez- Rosenberg, Sylvia Patricia Adelheid, Gerardo Aceves Medina, and Ricardo Javier Saldierna Martinez. "UPDATED TAXONOMIC LIST OF FISH LARVAE FROM BAHÍA SEBASTIÁN VIZCAÍNO, BAJA CALIFORNIA, MÉXICO." CICIMAR Oceánides 35, no. (1-2) (December 31, 2020): 63–78. http://dx.doi.org/10.37543/oceanides.v35i(1-2).268.
Повний текст джерелаАнотація:
Larvae of 152 fish families were identified in the California Current between 1949-1994 through the CalCOFI Program. Sampling efforts in the southern California Current restarted in 1997 with the ongoing IMECOCAL Program, which includes the transitional area of Bahía Sebastián Vizcaíno (BSV). This work updates the fish larvae taxonomic list of BSV, summarizing the 20-year sampling efforts. Results showed 341 identified taxa (227 to species level, 60 to genus and 54 to family), representing 97 families. The most abundant were Phosichthyidae (37%), Myctophidae (14%) and Synodontidae (9%). Pelagic neritic species Engraulis mordax (Engraulidae) and Sardinops sagax (Clupeidae) showed their maximum larval abundance during spring and winter, respectively. Myctophidae contributed with the highest species richness (39 taxa in 20 genera), followed by the reef-associated Sebastidae (21 taxa in the Sebastes genus). Identified taxa were mostly from southern (tropical) zoogeographic affinity (80%), and a minor component had northern (boreal) affinity (8%) or wide distribution in the northeastern Pacific Ocean (12%). The highest larval abundance and species richness were registered during summer (207 taxa) and fall (219 taxa). In winter and spring, larval abundance and richness decreased almost 50%, however the number of dominant species was higher. The previous ichthyoplankton list for BSV included only samples taken during 1997-2001 and reported larvae of 158 taxa in 71 families, where mesopelagic larvae contributed with most of the bundance and taxonomic richness (˃20%). Seasonal abundance of pelagic neritic species showed a spawning preference for spring and summer conditions. For demersal species, diversity and abundance increased during fall. With this work we increase from 158 to 341 registered taxa, most of them associated to demersal reef habitats with southern distribution. One third of the taxa found (114) could not be identified to species level, highlighting the urgency for more taxonomic studies of ichthyoplankton in the area.
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Frenet, Emeline Masson, Chiseko Watanabe, Helen Bentsen, Bryana Chowtee, WenJun Liu, Cynthia Romeo, Dorothy Sung, and Alexandra Jimenez. "Abstract 31 Testing of Cord Blood Units for Non-Hematopoietic Markers." Stem Cells Translational Medicine 11, Supplement_1 (September 1, 2022): S37. http://dx.doi.org/10.1093/stcltm/szac057.031.
Повний текст джерелаАнотація:
Abstract Introduction Cord blood units (CBU) are tested at banking for markers relevant to donor safety (infectious disease markers) and hematopoietic stem cell transplantation (cellularity and HLA typing). As CBUs are being increasingly used for new, non-transplant purposes, additional markers are sometimes needed for CBU selection. Objective We describe here our procedure for testing CBU, looking for specific NK cell characteristics: KIR haplotype B (associated with more activating KIRs), and Fc gamma receptor III A (FCGR3A) 158 V/V (presence of a homozygous valine in position 158) polymorphism (which has a higher affinity for IgG), as requested by some of our clients for non-transplant studies. Methods First, a list of eligible CBUs was established, based on the order specifications. Testing was requested from an outside lab (Histogenetics, Ossining, New York). As CBU DNA is a precious resource, we wanted to limit the number of new samples to be sent by first testing leftover samples from HLA typing, then sending additional samples to the lab, to reach the required number of CBUs. Testing was done sequentially (Figure 1): first, KIR typing, then FCGR3A polymorphism on the CBU with KIR B haplotype. Results A total of 216 samples were selected for KIR testing (130 from stored DNA and 86 from newly sent DNA); 154 (71%) were found to have at least one B haplotype receptor. For those, FCGR3A polymorphism was tested; 60 samples (39%) were F/F, 70 (46%) F/V, and 23 (15%) V/V (Figure 1), in line with expected frequencies from the literature. Average TAT for KIR testing was 13 days and an additional 18 days for FCGRA3. Discussion Performing additional testing can easily be integrated into a bank’s routine and help select CBU for purposes other than transplantation. When several markers are needed, sequential testing is an efficient and cost-saving method.
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Al-Gburi, Sarah, Haidar Kadhim, and Haider Ghazi. "Association of CD46 Cellular Receptor Gene SNP in Measles Vaccine Response." Iraqi Journal of Medical Sciences 18, no. 1 (June 30, 2020): 39–46. http://dx.doi.org/10.22578/ijms.18.1.6.
Повний текст джерелаАнотація:
Background: Measles is a highly contagious viral disease. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine. Measles transmitted via droplets from the nose, mouth or throat of infected persons. Objective: To evaluate the immune response to measles infection among immunized school aged children, and to detect the cluster of differentiation 46 single nucleotide polymorphism (CD46 SNP) in association with the immune response. Methods: The current study is a cross sectional study including 158 hospitalized patients were previously vaccinated with two doses of measles-mumps-rubella vaccine. The ages of patients were 5-10 years school aged children. All samples were collected from blood collection unit in Al-Imamein Al-Kadhimein Medical city during the period from December 2018 to April 2019. The detection was based on the presence of IgG Antibody to measles. The positive results were considered according to enzyme linked immunosorbant assay and conventional polymerase chain reaction to detect CD46 SNP. Results: Among those 158 subjects' male children count for 62% and female children were 38%. Forty-one (41) immunized children (with mean age 7.98±1.92 years) were low immune response to measles vaccine (MV). On the other hand, only two cases (with mean age 5.50±0.71 years) were negative to measles virus vaccine. Conclusion: Ensuring two doses of MV give protective immune response to MV may declines with aging. CD46 cellular receptor gene SNP (rs7144) may play role in reduction in immune response to MV. Keywords: Measles, MMR, CD46, SNP, Iraq Citation: Al-Gburi SAJ, Kadhim HS, Ghazi HF. Association of CD46 Cellular Receptor Gene SNP in measles vaccine response. Iraqi JMS. 2020; 18(1): 39-46. doi: 10.22578/IJMS.18.1.6
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Sprügel, Maximilian I., Joji B. Kuramatsu, Stefan T. Gerner, Jochen A. Sembill, Julius Hartwich, Antje Giede-Jeppe, Dominik Madžar, et al. "Presence of Concomitant Systemic Cancer is Not Associated with Worse Functional Long-Term Outcome in Patients with Intracerebral Hemorrhage." Cerebrovascular Diseases 44, no. 3-4 (2017): 186–94. http://dx.doi.org/10.1159/000479075.
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Background: Data on clinical characteristics and outcome of patients with intracerebral hemorrhage (ICH) and concomitant systemic cancer disease are very limited. Methods: Nine hundred and seventy three consecutive primary ICH patients were analyzed using our prospective institutional registry over a period of 9 years (2006-2014). We compared clinical and radiological parameters as well as outcome - scored using the modified Rankin Scale (mRS) and analyzed in a dichotomized fashion as favorable outcome (mRS = 0-3) and unfavorable outcome (mRS = 4-6) - of ICH patients with and without cancer. Relevant imbalances in baseline clinical and radiological characteristics were adjusted using propensity score (PS) matching. Results: Prevalence of systemic cancer among patients with ICH was 8.5% (83/973). ICH patients with cancer were older (77 [70-82] vs. 72 [63-80] years; p = 0.002), had more often prior renal dysfunction (19/83 [22.9%] vs.107/890 [12.0%]; p = 0.005), and smaller hemorrhage volumes (10.1 [4.8-24.3] vs. 15.3 [5.4-42.9] mL; p = 0.017). After PS-matching there were no significant differences neither in mortality nor in functional outcome both at 3 months (mortality: 33/81 [40.7%] vs. 55/158 [34.8%]; p = 0.368; mRS = 0-3: 28/81 [34.6%] vs. 52/158 [32.9%]; p = 0.797) and 12 months (mortality: 39/78 [50.0%] vs. 70/150 [46.7%]; p = 0.633; mRS = 0-3: 25/78 [32.1%] vs. 53/150 [35.3%]; p = 0.620) among patients with and without concomitant systemic cancer. ICH volume tended to be highest in patients with hematooncologic malignancy and smallest in urothelial cancer. Conclusions: Patients with ICH and concomitant systemic cancer on average are older; however, they show smaller ICH volumes compared to patients without cancer. Yet, mortality and functional outcome is not different in ICH patients with and without cancer. Thus, the clinical history or the de novo diagnosis of concomitant malignancies in ICH patients should not lead to unjustified treatment restrictions.
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Molodan, Andrii, Oleksandr Polyanskyi, Yevhen Dubinin, Mykola Artomov, and Oleh Pushkarenko. "Change in power and fuel consumption when engine cylinders are partially disabled in a wheeled vehicle." Central Ukrainian Scientific Bulletin. Technical Sciences 2, no. 8(39) (2023): 150–58. http://dx.doi.org/10.32515/2664-262x.2023.8(39).2.150-158.
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The provided calculation methodology enables the evaluation of how disconnected cylinders affect engine power, overall efficiency, and fuel consumption. The study establishes that disconnecting cylinders leads to a proportional decrease in engine power. This means that an engine generating 154,5 kW power reduces to 113,4 kW with two disabled cylinders and goes down to 70,3 kW when four cylinders are disconnected. Reducing fuel consumption is especially notable at idle, showing a 27% drop after disabling half of the cylinders. However, fuel efficiency declines as the engine load increases until it reaches zero at the engine load factor. Discrepancies between the experimental and calculated data on fuel consumption and power are minimal, at around 7-8% during maximum load. Diesel engines have the potential to improve efficiency by shutting down certain cylinders, but the actual fuel savings depend on several factors, including the number of active cylinders, engine configuration, load, and mechanical losses incurred by the shutdown cylinders. A method for analyzing additional energy losses in the engine caused by forced and natural vibrations of motor-transmission systems in wheeled vehicles has been improved. The analysis utilizes the Meander function in the context of harmonic moment and Fourier series. This text describes a method for determining the power of mechanical losses and energy for pumping strokes, while considering changes in the temperature regime in disconnected engine cylinders at increased torque irregularity. It also determines the permissible number of disconnected cylinders, taking into account their effect on power and reliability of wheeled machines. This paper presents a method for evaluating the dependability of fundamental engine components in the context of increased torque irregularity resulting from the disconnection of some cylinders.