Готові списки джерел за темами / 12-helix

Добірка наукової літератури з теми "12-helix"

Автор: Grafiati

Опубліковано: 6 вересня 2023

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Статті в журналах з теми "12-helix"

Henderson, Peter J. F. "The 12-transmembrane helix transporters." Current Opinion in Cell Biology 5, no. 4 (August 1993): 708–21. http://dx.doi.org/10.1016/0955-0674(93)90144-f.

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Fratev, Filip. "PPARγ helix 12 exhibits an antagonist conformation". Physical Chemistry Chemical Physics 18, № 13 (2016): 9272–80. http://dx.doi.org/10.1039/c5cp06729d.

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Thodupunuri, Prashanth, Sirisha Katukuri, Kallaganti V. S. Ramakrishna, Gangavaram V. M. Sharma, Ajit C. Kunwar, Akella V. S. Sarma та Hans-Jörg Hofmann. "Solvent-Directed Switch of a Left-Handed 10/12-Helix into a Right-Handed 12/10-Helix in Mixed β-Peptides". Journal of Organic Chemistry 82, № 4 (лютий 2017): 2018–31. http://dx.doi.org/10.1021/acs.joc.6b02856.

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Fratev, Filip. "Activation helix orientation of the estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations." Physical Chemistry Chemical Physics 17, no. 20 (2015): 13403–20. http://dx.doi.org/10.1039/c5cp00327j.

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Fernandes, Carlos, Sophie Faure, Elisabeth Pereira, Vincent Théry, Valérie Declerck, Régis Guillot та David J. Aitken. "12-Helix Folding of Cyclobutane β-Amino Acid Oligomers". Organic Letters 12, № 16 (20 серпня 2010): 3606–9. http://dx.doi.org/10.1021/ol101267u.

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Misra, Rajkumar, K. Muruga Poopathi Raja, Hans-Jörg Hofmann та Hosahudya N. Gopi. "Modulating the Structural Properties of α,γ-Hybrid Peptides by α-Amino Acid Residues: Uniform 12-Helix Versus “Mixed” 12/10-Helix". Chemistry - A European Journal 23, № 65 (3 листопада 2017): 16644–52. http://dx.doi.org/10.1002/chem.201703871.

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Sölter, Marion, Manfred Köster, Thomas Hollemann, Andreas Brey, Tomas Pieler, and Walter Knöchel. "Characterization of a subfamily of related winged helix genes, XFD-12/12′/12″ (XFLIP), during Xenopus embryogenesis." Mechanisms of Development 89, no. 1-2 (December 1999): 161–65. http://dx.doi.org/10.1016/s0925-4773(99)00195-1.

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Hamad, Mohamad A., and Matthew L. Nilles. "Structure-Function Analysis of the C-Terminal Domain of LcrV from Yersinia pestis." Journal of Bacteriology 189, no. 18 (July 20, 2007): 6734–39. http://dx.doi.org/10.1128/jb.00539-07.

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ABSTRACT LcrV, a multifunctional protein, acts as a positive regulator of effector protein secretion for the type III secretion system (T3SS) in Yersinia pestis by interaction with the negative regulator LcrG. In this study, LcrV was analyzed to identify regions required for LcrG interaction. Random-linker insertion mutagenesis, deletion analysis, and site-directed mutagenesis of hydrophobic amino acids between residues 290 and 311 allowed the isolation of an LcrV mutant (LcrV L291R F308R) defective for LcrG interaction. The new residues identified in LcrG interaction lie in helix 12 of LcrV; residues in helix 7 of LcrV are known to be involved in LcrG interaction. Helix 7 and helix 12 of LcrV interact to form an intramolecular coiled coil; these new results suggest that the intramolecular coiled coil in LcrV is required for LcrG interaction and activation of the T3SS.

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Shizu, Ryota, Hikaru Nishiguchi, Sarii Tashiro, Takumi Sato, Ayaka Sugawara, Yuichiro Kanno, Takuomi Hosaka, Takamitsu Sasaki, and Kouichi Yoshinari. "Helix 12 stabilization contributes to basal transcriptional activity of PXR." Journal of Biological Chemistry 297, no. 3 (September 2021): 100978. http://dx.doi.org/10.1016/j.jbc.2021.100978.

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Baker, J. E. "Mounting Bennett's double helix on his skew 12-bar linkage." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 222, no. 8 (August 1, 2008): 1575–82. http://dx.doi.org/10.1243/09544062jmes875.

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The many facets of Bennett's investigation into his skew four-bar linkage and its several extensions have given rise to an abundance of studies by other workers. Among his imaginative endeavours was the deployment of a double helix to convert his planar 12-bar network into a spatial counterpart. A geometrically attractive idea, its algebraic equivalent had been difficult to realize because of a lack of underlying analytical relationships. As well, recent papers have revealed apparent shortcomings in Bennett's representation. The present work is an attempt to provide a complete algebraic treatment of Bennett's novel device.

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Більше джерел

Дисертації з теми "12-helix"

Batista, Mariana Raquel Bunoro. "Mobilidade da hélice 12 de receptores nucleares: comparação entre simulações de dinâmica molecular e experimentos de anisotropia de fluorescência." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-18042013-152451/.

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Receptores nucleares formam uma superfamília de proteínas responsáveis pela regulação da expressão de genes. Estruturalmente, são formados por três domínios: um domínio N-terminal bastante variável, um domínio altamente conservado de ligação com o DNA e um domínio C-terminal, menos conservado, denominado domínio de ligação com o ligante (LDB). Diversos experimentos mostram que a interação com o ligante afeta a estrutura e a mobilidade da hélice C-terminal dos receptores nucleares (hélice 12 do domínio de ligação com o ligante), sendo o principal mecanismo de ativação e repressão da transcrição. As primeiras estruturas de LBDs de receptores nucleares revelaram importantes diferenças entre estruturas contendo ligantes (holo) e estruturas apo, principalmente no que diz respeito a posição da hélice 12: em estruturas apo, foi observada a H12 em uma conformação aberta, expondo o sítio de ligação com o ligante, enquanto que em estruturas holo, foi observada a H12 em uma conformação fechada, dobrada sobre o corpo do LBD e envolvendo completamente o ligante. Essa diferença sugeriu um mecanismo para a entrada e saída de ligantes do sítio de ligação denominado modelo da ratoeira, entretanto, esse modelo apresenta diversas inconsistências e tem sido desacreditado. Estudos experimentais e teóricos recentes mostram que a hélice 12 é mais móvel na ausência de ligantes, entretanto, esses estudos não fornecem evidencias de que o aumento da mobilidade da está associado com o deslocamento da H12 em relação ao corpo do LBD, como sugerido pelo modelo da ratoeira. Embora esteja claro que a hélice 12 é mais móvel na ausência de ligantes, a dimensão da variação conformacional sofrida pela hélice 12 ainda não está clara. Nesse trabalho buscamos a construção de um modelo capaz de dimensionar a mobilidade da hélice 12 através da comparação direta entre simulações de dinâmica molecular e experimentos de anisotropia de fluorescência resolvida no tempo. Utilizando simulações de dinâmica molecular reproduzimos experimentos de anisotropia de fluorescência acoplando a sonda cys-flúor a hélice 12 do PPARγ para estudar sua mobilidade. Mostramos que as observações experimentais só podem ser explicadas por conformações onde a sonda fluorescente permanece presa a superfície do LBD. Foi mostrado também que curvas de anisotropia com decaimentos comparáveis com os decaimentos experimentais estão associados a pequenas variações conformacionais de hélice 12. Simulações para dois modelos de apo-PPARγ com a H12 aberta em relação ao corpo do LBD e para as estruturas cristalográficas de apo-RXR e apo-ER, onde a H12 também adota uma conformação aberta, revelaram curvas de anisotropia com decaimentos mais rápidos que os experimentais. Esses resultados implicam em um modelo onde a H12 sofre alterações conformacionais locais, não apresentando variações tão dramáticas como o proposto pelo modelo da ratoeira.
Nuclear Hormone Receptors comprise a protein superfamily responsible for regulation of gene expression. Structurally, they are composed by three domains: a variable N-terminal domain, a highly conserved DNA-binding domain (DBD), and a less conserved C-terminal domain, known as ligand binding domain (LBD). Many experiments have shown that the interaction with ligands affects the structure and the mobility of nuclear receptors C-terminal helix (LBDs Helix 12), being the main mechanism of transcription activation and repression. The first nuclear receptor LBDs structures revealed important differences between ligand bound (holo) and apo-structures concerning the position of the H12: in apo structures, H12 adopted an open conformation, exposing the ligand binding pocket, whereas in holo structures, the H12 was closed, packed over the body of the LBD, burying completely the ligand. This difference suggested a mechanism for ligand entry and exit from the binding pocket called mouse-trap model, however this model has several inconsistencies and has been discredited. Recent experimental and theoretical studies have shown that H12 is more labile in the absence of ligand, but these studies dont provide evidences that the increase in the mobility is associated with the detachment of H12 from the body of the LBD as suggested by the mouse-trap model. Although its clear that H12 is more flexible in the absence of ligands, the size of the conformational changes undergone by H12 is not yet clear. In this work we seek to construct a definitive model for the range of motions that H12 may undergo in the presence or absence of ligand using molecular dynamics simulations. Through direct comparison between molecular dynamics simulations and time-resolved fluorescence anisotropy experiments, we show that experimental observation can only be explained by conformations where the fluorescent probe is interacting with the surface of the PPARγ surface. We also show that simulations with anisotropy decay rates comparable to the experimental decay are associated with small helix 12 conformational changes. Simulations with two models of apo-PPARγ with H12 detached from the body of the LBD and with crystallographic structures of apo-RXR and apo-ER, where the H12 also is in an open conformation, display anisotropy decay rates significantly faster than the experimental ones. These results imply a model for the molecular mobility of the LBD where H12 undergoes local conformational changes and should exhibit dynamic properties less dramatic than proposed by the mouse trap model.

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(9755543), Jason A. Goebel. "Aromaticity and Flexibility of Transmembrane Helix 12 Contribute to Substrate Recognition and Transport in Human P-Glycoprotein." Thesis, 2020.

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Human p-glycoprotein (P-gp) is an ATP-binding cassette transporter that actively transports a diverse set of substrates at the plasma membrane. Specifically, P-gp is expressed most highly at important blood tissue barriers on the lumenal side of endothelial cells and secretory tissues asymmetrically where it provides generalized protection against xenobiotics due to its promiscuous substrate binding pocket. Substrates typically interact with P-gp within the inner leaflet of the plasma membrane before being effluxed through large conformation changes driven by ATP binding and hydrolysis. Since many small molecule drugs are substrates of P-gp and P-gp has the ability to transport chemically and structurally diverse molecules, delivery of bioavailable small molecule therapies and treatment of diseases beyond blood-tissue barriers may be difficult. In cancer, expression of P-gp may confer a multidrug resistance phenotype due to upregulation of the MDR1 gene, which encodes P-gp, in response to treatment with chemotherapies. Treatments of diseases beyond blood-tissue barriers and some cancers may be more complex given the protective role of P-gp coupled with it promiscuous substrate binding site.
Many studies of P-gp have been centered around understanding the structure function relationship of how P-gp effluxes small molecules across the plasma membrane. Here we have used a transient Vaccinia virus expression system to rapidly express many mutants of P-gp in human cells for analysis. Transient expression using the Vaccinia system was optimized to produce a large amount of protein while avoiding significant cell death. Optimization of the Vaccinia expression system has also helped to show that changes in P-gp surface expression are not correlated to changes in substrate accumulation within cells expressing P-gp, a topic that has yet to be addressed within the field of P-gp study. Reduced surface expression of P-gp to 68% maintained the same level of reduced cellular accumulation of two substrates, calcein-AM and rhodamine 123, relative to a WT P-gp control. Further study of P-gp mutations revealed a Y998A mutation had a 90% reduction of surface expression but the same reduction of cellular accumulation of rhodamine 123 further supporting that changes in surface expression do not correlate to changes in substrate transport.
We then sought to demonstrate how flexibility in transmembrane helix (TMH) 12 of P-gp affected overall stability and transport ability in vitro. TMH 12 in inward facing conformations shows a region of decreased hydrogen bonding in the backbone of the helix leading to a “kink” present in many crystal structures of C. elegans and mouse P-gp as well as in an occluded structure of human P-gp. Outward facing crystal structures of C. elegans, mouse, and human P-gp show TMH 12 where the backbone of the helix is fully hydrogen bonded and ordered. The change in hydrogen bonding pattern and the presence of the kink in TMH 12 suggest the importance of flexibility in the function of TMH 12. Clustal Omega was used to align the primary structure of P-gp between 8 species and a conserved sequence of 996-PDYAKA-1001 was identified aligning with the kink observed in crystallographic data. The kinked nature of this region led to our development of a rigid poly-alanine mutation and a flexible poly-glycine mutation based on the propensity of these amnio acids to form helices. The more flexible poly-glycine mutation obtained no significant transport while the poly-alanine mutation maintained some ability to transport fluorescent substrate relative to a WT control. Crosslinking of the nucleotide binding domains (NBDs) revealed a decrease of NBD dimerization likely correlating to decreased transport. Thus, some degree of flexibility within the kink region is critical for substrate transport as rigid and flexible mutations of this region abrogate transport of fluorescent substrates.
While the substrate binding pocket it located towards the interior of P-gp within the lipid bilayer, it has been theorized that substrates may interact with P-gp at the lipid-protein interface of the inner leaflet near portals for substrate entry formed by pairs of helices either side of the protein. To test this hypothesis, aromatic residues on TMH 12 and adjacent elbow helix 2 near the interface region of the inner leaflet, that have also been observed to interact with a cyclic peptide in a crystal structure of P-gp, were mutated to alanine. Y998, on TMH 12, was shown to interact with the cyclic peptide and is ideally located at the protein-lipid interface near a surface formed by elbow helix 2 and TMH 9 and was observed to have the largest effect on substrate accumulation. Accumulation of fluorescent substrates, relative to WT P-gp, was increased though not all substrates were affected similarly. No increase of accumulation was observed with rhodamine 123 while accumulation of BD-prazosin increased 65% relative to WT P-gp. It is to be expected that the large diversity of substrates recognized by P-gp would interact preferentially with carrying residues at the protein-lipid interface similar to observations of substrate binding at the substrate binding pocket. Variability in accumulation signifies that substrates do interact with P-gp at the lipid-protein interface and substrates interact differently at this interface similarly to substrate interaction at the substrate biding pocket.

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George, Gijo. "Structural Insights into Peptide Foldamers Containing β or γ Amino Acid Residues Gained Using NMR Spectroscopy". Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5210.

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The work reported in this thesis is focused on understanding the conformational properties of peptide foldamers containing β or γ amino acid residues. Chapter 1 includes a brief state-of-the-art literature review on peptide foldamers containing β and/or γ amino acids. Chapter 2 describes the effect of insertion of an Aib residue in a β3(R) peptide sequence with the help of two model peptides of comparable length- Boc-[β3(R)Val]9-OMe and Boc-[(β3(R)Val)3-Aib-(β3(R)Val)4]-OMe. Results in chapter 2 demonstrate the influence of the gem-dimethyl effect of Aib residues on the conformation of Aib/β3(S) peptides. In principle, the nature and chirality of the component residues also might affect the conformation of the heterogeneous peptides. Chapter 3 attempts to demonstrate a few of such effects with the help of NMR studies on few model peptides- (Boc-(Val)2-Ala-(Leu)2-OMe, Boc-(Val)2-β3(S)Ala-(Leu)2-OMe, Boc-(Val)2-γ4(S)Ala-(Leu)2-OMe, Boc-Val-DVal-β3(S)Ala-(Leu)2-OMe & Boc-Val-DVal-γ4(S)Ala-(Leu)2-OMe) and with a crystal structure database (CSD) analysis. Chapter 4 reports the first solution state structural characterization of C12/C14/C12 helices in peptides of the type- [γ4(R)-Aib-γ4(R)]2 and [γ4(R)-α(L)-γ4(R)]2. Δδ values of amide NHs (from DMSO-d6 titration in CDCl3) in the hexapeptides used in this study, as well as the hydrogen bond parameters and some other features of the crystal structures, reported in a previous study consistently and conclusively points to the existence of the hydrogen bond heterogeneity in C12/C14/C12 helix. Chapter 5 demonstrates the effect of insertion of a DPro-Gly segment in a γ4(R) peptide sequence using three model peptides- Boc-γ4(R)Leu-γ4(R)Leu-γ4(R)Leu-γ4(R)Leu-DPro-Gly-γ4(R)Leu-γ4(R)Leu-γ4(R)Leu-γ4(R)Leu-OMe, Boc-γ4(R)Ile-γ4(R)Ile-γ4(R)Ile-γ4(R)Ile -DPro-Gly-γ4(R)Ile-γ4(R)Ile-γ4(R)Ile-γ4(R)Ile-OMe and Boc-γ4(R)Val-γ4(R)Val-γ4(R)Val-γ4(R)Val-DPro-Gly-γ4(R)Val-γ4(R)Val-γ4(R)Val-γ4(R)Val-OMe.
CSIR

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Leydesdorff, Loet. "The Triple Helix Model and the Study of Knowledge-based Innovation Systems. Int. Journal of Contemporary Sociology 42(1), 2005, 12-27." 2005. http://hdl.handle.net/10150/106148.

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This paper examines the changing nature of knowledge-based innovation systems in light of the dynamic interconnections between the university, industry and government. Industries have to assess in what way and to what extent they decide to internalize R&D functions. Universities position themselves in markets, both regionally and globally. Governments make informed trade-offs between investments in industrial policies, S&T policies, and/or delicate and balanced interventions at the structural level. Such policies can be expected to be successful insofar as one can anticipate and/or follow trends according to the dynamics of the new technologies in their different phases. The evolutionary perspective in economics can be complemented with a turn towards reflexivity in sociology in order to obtain a richer understanding of how the overlay of communications in university-industry-government relations reshapes the systems of innovations that are currently subjects of debate, policy-making, and scientific study.

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Книги з теми "12-helix"

Double helix. New York: Dial Books, 2004.

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Double Helix. Paw Prints 2008-05-22, 2008.

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Double Helix (Puffin Sleuth Novels). Puffin, 2005.

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Double Helix (Puffin Sleuth Novels). Tandem Library, 2005.

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Частини книг з теми "12-helix"

Brown, Jessica. "Fiction's Double-Helix." In Religion, Materialism and Ecology, 185–201. London: Routledge, 2023. http://dx.doi.org/10.4324/9781003320722-12.

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Mehari, Yohannes, Elias Pekkola, Jonna Hjelt, Yuzhuo Cai, Jari Stenvall, and Francisco Javier Ortega-Colomer. "Defining ‘Responsible’ in Responsible Research and Innovation: The Case of Quadruple Helix Innovation in the Energy Sector in the Tampere Region." In Innovation, Technology, and Knowledge Management, 199–225. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84044-0_10.

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AbstractThis paper aims to investigate the social innovation process in the innovation ecosystem of the Tampere region, taking the energy sector as an example. It focuses on analysing how responsible research and innovation (RRI) activities are understood by regional stakeholders, particularly regarding how the roles of different actors (universities, public agencies, industry, and citizens) are constituted, and how different actors facilitate social innovation. The research questions are approached by the conceptual framework of Quadruple Helix which is useful for understanding the roles of citizens and interwoven fabric in innovation ecosystems, including social innovation. Empirically, the paper is based on analysing qualitative interviews with 12 stakeholders in the energy sector in Tampere. It is supplemented by analysing national and regional documents related to energy policies and the role of research and universities as well as citizens in sustainable (economic) development. Based on our findings the responsibility in research and innovation activities is not defined by utilising existing conceptual approaches or EU policies, such as RRI.

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Barrick, Douglas E. "The Helix–Coil Transition." In Biomolecular Thermodynamics, 373–402. Boca Raton : Taylor & Francis, 2017. | Series: Foundations of biochemistry and biophysics: CRC Press, 2017. http://dx.doi.org/10.1201/9781315380193-12.

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Griffith, Jeffrey, and Clare Sansom. "12-Helix H+/multidrug antiporter family." In The Transporter FactsBook, 357–63. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012303965-1/50038-x.

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"12 The Triple Helix Model as Alternative Economy." In Human and Technological Progress Towards the Socio-Economic Paradigm of the Future, Part 2, 107–16. De Gruyter, 2020. http://dx.doi.org/10.1515/9783110692082-012.

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Menon, S. K., and C. M. Lawrence. "Helix-Turn-Helix Motif." In Brenner's Encyclopedia of Genetics, 412–15. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-374984-0.00689-6.

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Etzkowitz, Henry, and Chunyan Zhou. "Venture Capital in the Triple Helix." In The Triple Helix, 180–201. Routledge, 2017. http://dx.doi.org/10.4324/9781315620183-12.

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Sartorelli, Vittorio, and Aster H. Juan. "Sculpting Chromatin Beyond the Double Helix." In Current Topics in Developmental Biology, 57–83. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-12-385940-2.00003-6.

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Johnson, Lisa M., and Samuel H. Gellman. "α-Helix Mimicry with α/β-Peptides." In Methods in Enzymology, 407–29. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-394292-0.00019-9.

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Rosenberg, Eugene. "DNA in Three Dimensions: The Double-Helix." In It's in Your DNA, 27–34. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-812502-1.00004-4.

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Тези доповідей конференцій з теми "12-helix"

Alaria, Mukesh Kumar, Sunny, A. K. Sinha, and V. Srivastava. "P2-12: Thermal analysis of slow wave structure for a space helix TWT." In 2010 IEEE International Vacuum Electronics Conference (IVEC). IEEE, 2010. http://dx.doi.org/10.1109/ivelec.2010.5503512.

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Jun, Martin B. G., and Anna Carla Araujo. "Modeling and Analysis of the Thread Milling Operation in the Combined Drilling/Thread Milling Process." In ASME 2008 International Manufacturing Science and Engineering Conference collocated with the 3rd JSME/ASME International Conference on Materials and Processing. ASMEDC, 2008. http://dx.doi.org/10.1115/msec_icmp2008-72209.

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This paper investigates a thread making process called thrilling, which performs both drilling and thread milling with one tool. A chip thickness and mechanistic cutting force model has been developed for a thread milling operation with a thrilling tool. The model considers the complex geometry of a thrilling tool and the unique tool paths associated with the thread milling operation. Calibration experiments have been conducted to estimate the cutting coefficients associated with specific cutting energies. Experiments have been conducted to validate the developed model. Comparison of the average torque and forces between experiment and simulation results shows that the model predicts the experimental results within 12% error. The model has also been used to analyze the effects of helix angle and number of engaged threads on the cutting forces.

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Han, J. T., C. X. Lin, and M. A. Ebadian. "Experimental Investigation of Condensation Heat Transfer of Refrigerant R-134A in Helicoidal Pipes." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1510.

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Abstract Alternative refrigerant R-134a is considered to be ozone-friendly and a potential candidate for replacing the refrigerant CFC-12 in refrigeration and air-conditioning applications. This paper presents the experimental investigation of condensation heat transfer characteristics of superheated R-134a vapor flowing inside helicoidal pipes with the cooling water flowing through the annular helicoidal passage in a counter-flow direction. The heat transfer experiment was performed for R-134a mass flow flux ranging from 100 to 420 kg/m2s with the superheat of the inlet vapor of 2.8°C and 8.3°C, respectively. The cooling water flow Reynolds Rew ranges from 1500 to 12000. The Nusselt numbers were experimentally determined for a helicoidal pipe with the helix axis of vertical direction. The correlations for Nusselt numbers are developed based on the experimental results, which can be used as a reference in the design of helicoidal pipe condensers.

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Fukunaga, Keigo, Syunji Inoue, Masataka Yonekura, and Isao Sakuragi. "Direct Dry Hobbing of High Hardened Material: RGC (Round Bar Gear Cutting) Method." In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/ptg-48070.

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Almost all customers require gear motor manufacturers to develop low noise, low vibration and low cost gear motors. Low noise and low vibration gear motors can be accomplished only by using high precision gears. The traditional method of manufacturing high precision gears for general industries is to grind the teeth after gear cutting. However, recently, there is now a strong demand to increase productivity and reduce manufacturing cost by using only a hobbing machine. To content these requirements, it is believed that direct dry hobbing after gear material heat treatment is the best manufacturing method. First, 0.45% carbon steel of round gear material was hardened to HRC53-56 by high frequency induction heat treatment till the specified depth. Next, the high hardened material was directly hobbed by special carbide hob installed on a highly rigid CNC (Computer Numerical Control) hobbing machine without using cutting oils. In the other words, the authors have developed Direct Dry Hobbing of High hardened Material, called the RGC (Round bar Gear Cutting) Method. The gears applying the RGC Method were module 0.8 to 1.25 and of helix angle 25°. The gear profile accuracy was JIS Grade 1–2, which is comparable to AGMA Grade 11–12. Gear motors incorporating gears manufactured by the RGC Method have been launched into the market and are now receiving remarkable customers satisfaction as low noise and low vibration gear motors.

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Batista, Michael, Hadi T. Nia, Karen Cox, Christine Ortiz, Alan J. Grodzinsky, Dick Heinegård, and Lin Han. "Effects of Chondroadherin on Cartilage Nanostructure and Biomechanics via Murine Model." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14516.

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While small leucine rich proteins/proteoglycans (SLRPs) are present in very low concentrations in the extracellular matrix (ECM), they have been shown to be critical determinants of the proper ECM assembly and function in connective tissues [1] including bone [2], cornea [3], and cartilage [4]. However, their direct and indirect roles in matrix biomechanics and the potential for osteoarthritis-related dysfunction of cartilage remain unclear. With the advent of new high resolution nanotechnological tools, the direct quantification of cartilage biomechanical properties using murine models can provide important insights into how secondary ECM molecules, such as SLRPs, affect the function and pathology of cartilage [5]. Previous nanoindentation studies of murine cartilage have assessed the effects of maturation and osteoarthritis-like degradation of cartilage on its biomechanical properties [6, 7]. Recently, murine models have received increased attention because of the availability of specific gene-knockout and gene alteration technologies [8]. For example, chondroadherin (CHAD) is a non-collagenous small leucine-rich proteoglycan (SLRP) with α-helix and β-sheet secondary structure, spatially localized in the territorial matrix (MW = 38 kDa) [9]. In articular cartilage, CHAD is distributed non-uniformly with depth [10], and binds to type II collagen and the α2β1 integrin and is hypothesized to function in the communication between chondrocytes and their surrounding matrix, as well as in the regulation of collagen fibril assembly [11, 12] (Fig. 1). The objective of the present study is to explore the role of CHAD and its depletion on the structure and nanomechanical properties of both superficial and middle/deep zone cartilage. The current methods thereby enabled depth-dependent analysis of cartilage nanostructure and dynamic energy-dissipative mechanisms.

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Liebenberg, Leon, Arthur E. Bergles, and Josua P. Meyer. "A Review of Refrigerant Condensation in Horizontal Micro-Fin Tubes." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1308.

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Abstract This paper reviews currently available experimental evidence and predictive techniques for heat transfer and pressure drop during film condensation in horizontal micro-fin tubes, as used in heat pump systems. The enhanced heat transfer mechanism of condensation using micro-fin tubes is explained, and special attention is paid to the dependence of heat transfer and pressure drop on the geometric parameters of the micro-fin tube. It is shown that most of the existing predictive heat transfer and pressure drop models employ strictly empirical techniques. The difficulty of accurate (analytic) modeling of micro-fin tubes lies in the numerous dimensional variables involved in the tube surface, and these are also reported. Heat transfer and pressure drop correlations for micro-fin tubes are presented for pure single fluids and pure mixtures (i.e. R-12, R-125, R-22, R-134a, R-113, R-407C, R-410A, R-32/R-134a, and R-22/R-502/R-134a). The saturation temperatures vary between 22 to 53°C, the mass fluxes between 84 to 910 kg/(m2s), tube diameters between 5.95 to 14.18mm, the number of fins from 24 to 65, fin heights between 0.1 to 0.25mm, apex angles from 25 to 90°, and helix (spiral) angles from 7 to 30°. Correction techniques are suggested when using refrigerant mixtures. It is shown that the currently available correlations satisfy only limited experimental data for a limited number of refrigerants, and that there is little unanimity over a single correlation. The appraisal of the existing correlations by numerous researchers is presented, and recommendations for design calculations are made.

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Scully, Kathleen M., Reyhaneh Lahmy, Heejung Kim, Andrew Lowy, and Pamela Itkin-Ansari. "Abstract A55: Overexpression of the basic helix-loop-helix transcription factor, E47, promotes p16-independent senescence in established and patient-derived xenograft lines." In Abstracts: AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; May 12-15, 2016; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.panca16-a55.

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Lahmy, Reyhaneh, Nicholas Villarino, Jaco van Niekerk, Tarek Almaleh, SangWun Kim, Andrew Lowy, and Pamela Itkin-Ansari. "Abstract B48: A novel high throughput screening platform identifies statins as inducers of basic Helix-Loop-Helix activity, p21 and growth arrest in pancreatic cancer cell and patient derived xenograft lines." In Abstracts: AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; May 12-15, 2016; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.panca16-b48.

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Febriana, Poppy, Isnaini Rodiyah, and Wiwik Sulistiyowati. "Implementation of Information and Communication Technology to Improve Product Quality and Partnerships with The Quadruple Helix Method Approach." In International Conference on Emerging Media, and Social Science. EAI, 2019. http://dx.doi.org/10.4108/eai.7-12-2018.2281802.

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Yoshizumi, K., M. Kohda, and J. Nitta. "Gate Controlled Switching between Two Different Persistent Spin Helix States and Determination of Dresselhaus Spin-orbit Interaction Parameter." In 2016 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2016. http://dx.doi.org/10.7567/ssdm.2016.ps-12-01.

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