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Статті в журналах з теми "12-helix"
Henderson, Peter J. F. "The 12-transmembrane helix transporters." Current Opinion in Cell Biology 5, no. 4 (August 1993): 708–21. http://dx.doi.org/10.1016/0955-0674(93)90144-f.
Повний текст джерелаFratev, Filip. "PPARγ helix 12 exhibits an antagonist conformation". Physical Chemistry Chemical Physics 18, № 13 (2016): 9272–80. http://dx.doi.org/10.1039/c5cp06729d.
Повний текст джерелаThodupunuri, Prashanth, Sirisha Katukuri, Kallaganti V. S. Ramakrishna, Gangavaram V. M. Sharma, Ajit C. Kunwar, Akella V. S. Sarma та Hans-Jörg Hofmann. "Solvent-Directed Switch of a Left-Handed 10/12-Helix into a Right-Handed 12/10-Helix in Mixed β-Peptides". Journal of Organic Chemistry 82, № 4 (лютий 2017): 2018–31. http://dx.doi.org/10.1021/acs.joc.6b02856.
Повний текст джерелаFratev, Filip. "Activation helix orientation of the estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations." Physical Chemistry Chemical Physics 17, no. 20 (2015): 13403–20. http://dx.doi.org/10.1039/c5cp00327j.
Повний текст джерелаFernandes, Carlos, Sophie Faure, Elisabeth Pereira, Vincent Théry, Valérie Declerck, Régis Guillot та David J. Aitken. "12-Helix Folding of Cyclobutane β-Amino Acid Oligomers". Organic Letters 12, № 16 (20 серпня 2010): 3606–9. http://dx.doi.org/10.1021/ol101267u.
Повний текст джерелаMisra, Rajkumar, K. Muruga Poopathi Raja, Hans-Jörg Hofmann та Hosahudya N. Gopi. "Modulating the Structural Properties of α,γ-Hybrid Peptides by α-Amino Acid Residues: Uniform 12-Helix Versus “Mixed” 12/10-Helix". Chemistry - A European Journal 23, № 65 (3 листопада 2017): 16644–52. http://dx.doi.org/10.1002/chem.201703871.
Повний текст джерелаSölter, Marion, Manfred Köster, Thomas Hollemann, Andreas Brey, Tomas Pieler, and Walter Knöchel. "Characterization of a subfamily of related winged helix genes, XFD-12/12′/12″ (XFLIP), during Xenopus embryogenesis." Mechanisms of Development 89, no. 1-2 (December 1999): 161–65. http://dx.doi.org/10.1016/s0925-4773(99)00195-1.
Повний текст джерелаHamad, Mohamad A., and Matthew L. Nilles. "Structure-Function Analysis of the C-Terminal Domain of LcrV from Yersinia pestis." Journal of Bacteriology 189, no. 18 (July 20, 2007): 6734–39. http://dx.doi.org/10.1128/jb.00539-07.
Повний текст джерелаShizu, Ryota, Hikaru Nishiguchi, Sarii Tashiro, Takumi Sato, Ayaka Sugawara, Yuichiro Kanno, Takuomi Hosaka, Takamitsu Sasaki, and Kouichi Yoshinari. "Helix 12 stabilization contributes to basal transcriptional activity of PXR." Journal of Biological Chemistry 297, no. 3 (September 2021): 100978. http://dx.doi.org/10.1016/j.jbc.2021.100978.
Повний текст джерелаBaker, J. E. "Mounting Bennett's double helix on his skew 12-bar linkage." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 222, no. 8 (August 1, 2008): 1575–82. http://dx.doi.org/10.1243/09544062jmes875.
Повний текст джерелаДисертації з теми "12-helix"
Batista, Mariana Raquel Bunoro. "Mobilidade da hélice 12 de receptores nucleares: comparação entre simulações de dinâmica molecular e experimentos de anisotropia de fluorescência." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-18042013-152451/.
Повний текст джерелаNuclear Hormone Receptors comprise a protein superfamily responsible for regulation of gene expression. Structurally, they are composed by three domains: a variable N-terminal domain, a highly conserved DNA-binding domain (DBD), and a less conserved C-terminal domain, known as ligand binding domain (LBD). Many experiments have shown that the interaction with ligands affects the structure and the mobility of nuclear receptors C-terminal helix (LBDs Helix 12), being the main mechanism of transcription activation and repression. The first nuclear receptor LBDs structures revealed important differences between ligand bound (holo) and apo-structures concerning the position of the H12: in apo structures, H12 adopted an open conformation, exposing the ligand binding pocket, whereas in holo structures, the H12 was closed, packed over the body of the LBD, burying completely the ligand. This difference suggested a mechanism for ligand entry and exit from the binding pocket called mouse-trap model, however this model has several inconsistencies and has been discredited. Recent experimental and theoretical studies have shown that H12 is more labile in the absence of ligand, but these studies dont provide evidences that the increase in the mobility is associated with the detachment of H12 from the body of the LBD as suggested by the mouse-trap model. Although its clear that H12 is more flexible in the absence of ligands, the size of the conformational changes undergone by H12 is not yet clear. In this work we seek to construct a definitive model for the range of motions that H12 may undergo in the presence or absence of ligand using molecular dynamics simulations. Through direct comparison between molecular dynamics simulations and time-resolved fluorescence anisotropy experiments, we show that experimental observation can only be explained by conformations where the fluorescent probe is interacting with the surface of the PPARγ surface. We also show that simulations with anisotropy decay rates comparable to the experimental decay are associated with small helix 12 conformational changes. Simulations with two models of apo-PPARγ with H12 detached from the body of the LBD and with crystallographic structures of apo-RXR and apo-ER, where the H12 also is in an open conformation, display anisotropy decay rates significantly faster than the experimental ones. These results imply a model for the molecular mobility of the LBD where H12 undergoes local conformational changes and should exhibit dynamic properties less dramatic than proposed by the mouse trap model.
(9755543), Jason A. Goebel. "Aromaticity and Flexibility of Transmembrane Helix 12 Contribute to Substrate Recognition and Transport in Human P-Glycoprotein." Thesis, 2020.
Знайти повний текст джерелаMany studies of P-gp have been centered around understanding the structure function relationship of how P-gp effluxes small molecules across the plasma membrane. Here we have used a transient Vaccinia virus expression system to rapidly express many mutants of P-gp in human cells for analysis. Transient expression using the Vaccinia system was optimized to produce a large amount of protein while avoiding significant cell death. Optimization of the Vaccinia expression system has also helped to show that changes in P-gp surface expression are not correlated to changes in substrate accumulation within cells expressing P-gp, a topic that has yet to be addressed within the field of P-gp study. Reduced surface expression of P-gp to 68% maintained the same level of reduced cellular accumulation of two substrates, calcein-AM and rhodamine 123, relative to a WT P-gp control. Further study of P-gp mutations revealed a Y998A mutation had a 90% reduction of surface expression but the same reduction of cellular accumulation of rhodamine 123 further supporting that changes in surface expression do not correlate to changes in substrate transport.
We then sought to demonstrate how flexibility in transmembrane helix (TMH) 12 of P-gp affected overall stability and transport ability in vitro. TMH 12 in inward facing conformations shows a region of decreased hydrogen bonding in the backbone of the helix leading to a “kink” present in many crystal structures of C. elegans and mouse P-gp as well as in an occluded structure of human P-gp. Outward facing crystal structures of C. elegans, mouse, and human P-gp show TMH 12 where the backbone of the helix is fully hydrogen bonded and ordered. The change in hydrogen bonding pattern and the presence of the kink in TMH 12 suggest the importance of flexibility in the function of TMH 12. Clustal Omega was used to align the primary structure of P-gp between 8 species and a conserved sequence of 996-PDYAKA-1001 was identified aligning with the kink observed in crystallographic data. The kinked nature of this region led to our development of a rigid poly-alanine mutation and a flexible poly-glycine mutation based on the propensity of these amnio acids to form helices. The more flexible poly-glycine mutation obtained no significant transport while the poly-alanine mutation maintained some ability to transport fluorescent substrate relative to a WT control. Crosslinking of the nucleotide binding domains (NBDs) revealed a decrease of NBD dimerization likely correlating to decreased transport. Thus, some degree of flexibility within the kink region is critical for substrate transport as rigid and flexible mutations of this region abrogate transport of fluorescent substrates.
While the substrate binding pocket it located towards the interior of P-gp within the lipid bilayer, it has been theorized that substrates may interact with P-gp at the lipid-protein interface of the inner leaflet near portals for substrate entry formed by pairs of helices either side of the protein. To test this hypothesis, aromatic residues on TMH 12 and adjacent elbow helix 2 near the interface region of the inner leaflet, that have also been observed to interact with a cyclic peptide in a crystal structure of P-gp, were mutated to alanine. Y998, on TMH 12, was shown to interact with the cyclic peptide and is ideally located at the protein-lipid interface near a surface formed by elbow helix 2 and TMH 9 and was observed to have the largest effect on substrate accumulation. Accumulation of fluorescent substrates, relative to WT P-gp, was increased though not all substrates were affected similarly. No increase of accumulation was observed with rhodamine 123 while accumulation of BD-prazosin increased 65% relative to WT P-gp. It is to be expected that the large diversity of substrates recognized by P-gp would interact preferentially with carrying residues at the protein-lipid interface similar to observations of substrate binding at the substrate binding pocket. Variability in accumulation signifies that substrates do interact with P-gp at the lipid-protein interface and substrates interact differently at this interface similarly to substrate interaction at the substrate biding pocket.
George, Gijo. "Structural Insights into Peptide Foldamers Containing β or γ Amino Acid Residues Gained Using NMR Spectroscopy". Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5210.
Повний текст джерелаCSIR
Leydesdorff, Loet. "The Triple Helix Model and the Study of Knowledge-based Innovation Systems. Int. Journal of Contemporary Sociology 42(1), 2005, 12-27." 2005. http://hdl.handle.net/10150/106148.
Повний текст джерелаКниги з теми "12-helix"
Double helix. New York: Dial Books, 2004.
Знайти повний текст джерелаDouble Helix. Paw Prints 2008-05-22, 2008.
Знайти повний текст джерелаDouble Helix (Puffin Sleuth Novels). Puffin, 2005.
Знайти повний текст джерелаDouble Helix (Puffin Sleuth Novels). Tandem Library, 2005.
Знайти повний текст джерелаЧастини книг з теми "12-helix"
Brown, Jessica. "Fiction's Double-Helix." In Religion, Materialism and Ecology, 185–201. London: Routledge, 2023. http://dx.doi.org/10.4324/9781003320722-12.
Повний текст джерелаMehari, Yohannes, Elias Pekkola, Jonna Hjelt, Yuzhuo Cai, Jari Stenvall, and Francisco Javier Ortega-Colomer. "Defining ‘Responsible’ in Responsible Research and Innovation: The Case of Quadruple Helix Innovation in the Energy Sector in the Tampere Region." In Innovation, Technology, and Knowledge Management, 199–225. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84044-0_10.
Повний текст джерелаBarrick, Douglas E. "The Helix–Coil Transition." In Biomolecular Thermodynamics, 373–402. Boca Raton : Taylor & Francis, 2017. | Series: Foundations of biochemistry and biophysics: CRC Press, 2017. http://dx.doi.org/10.1201/9781315380193-12.
Повний текст джерелаGriffith, Jeffrey, and Clare Sansom. "12-Helix H+/multidrug antiporter family." In The Transporter FactsBook, 357–63. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012303965-1/50038-x.
Повний текст джерела"12 The Triple Helix Model as Alternative Economy." In Human and Technological Progress Towards the Socio-Economic Paradigm of the Future, Part 2, 107–16. De Gruyter, 2020. http://dx.doi.org/10.1515/9783110692082-012.
Повний текст джерелаMenon, S. K., and C. M. Lawrence. "Helix-Turn-Helix Motif." In Brenner's Encyclopedia of Genetics, 412–15. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-374984-0.00689-6.
Повний текст джерелаEtzkowitz, Henry, and Chunyan Zhou. "Venture Capital in the Triple Helix." In The Triple Helix, 180–201. Routledge, 2017. http://dx.doi.org/10.4324/9781315620183-12.
Повний текст джерелаSartorelli, Vittorio, and Aster H. Juan. "Sculpting Chromatin Beyond the Double Helix." In Current Topics in Developmental Biology, 57–83. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-12-385940-2.00003-6.
Повний текст джерелаJohnson, Lisa M., and Samuel H. Gellman. "α-Helix Mimicry with α/β-Peptides." In Methods in Enzymology, 407–29. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-394292-0.00019-9.
Повний текст джерелаRosenberg, Eugene. "DNA in Three Dimensions: The Double-Helix." In It's in Your DNA, 27–34. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-812502-1.00004-4.
Повний текст джерелаТези доповідей конференцій з теми "12-helix"
Alaria, Mukesh Kumar, Sunny, A. K. Sinha, and V. Srivastava. "P2-12: Thermal analysis of slow wave structure for a space helix TWT." In 2010 IEEE International Vacuum Electronics Conference (IVEC). IEEE, 2010. http://dx.doi.org/10.1109/ivelec.2010.5503512.
Повний текст джерелаJun, Martin B. G., and Anna Carla Araujo. "Modeling and Analysis of the Thread Milling Operation in the Combined Drilling/Thread Milling Process." In ASME 2008 International Manufacturing Science and Engineering Conference collocated with the 3rd JSME/ASME International Conference on Materials and Processing. ASMEDC, 2008. http://dx.doi.org/10.1115/msec_icmp2008-72209.
Повний текст джерелаHan, J. T., C. X. Lin, and M. A. Ebadian. "Experimental Investigation of Condensation Heat Transfer of Refrigerant R-134A in Helicoidal Pipes." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1510.
Повний текст джерелаFukunaga, Keigo, Syunji Inoue, Masataka Yonekura, and Isao Sakuragi. "Direct Dry Hobbing of High Hardened Material: RGC (Round Bar Gear Cutting) Method." In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/ptg-48070.
Повний текст джерелаBatista, Michael, Hadi T. Nia, Karen Cox, Christine Ortiz, Alan J. Grodzinsky, Dick Heinegård, and Lin Han. "Effects of Chondroadherin on Cartilage Nanostructure and Biomechanics via Murine Model." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14516.
Повний текст джерелаLiebenberg, Leon, Arthur E. Bergles, and Josua P. Meyer. "A Review of Refrigerant Condensation in Horizontal Micro-Fin Tubes." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1308.
Повний текст джерелаScully, Kathleen M., Reyhaneh Lahmy, Heejung Kim, Andrew Lowy, and Pamela Itkin-Ansari. "Abstract A55: Overexpression of the basic helix-loop-helix transcription factor, E47, promotes p16-independent senescence in established and patient-derived xenograft lines." In Abstracts: AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; May 12-15, 2016; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.panca16-a55.
Повний текст джерелаLahmy, Reyhaneh, Nicholas Villarino, Jaco van Niekerk, Tarek Almaleh, SangWun Kim, Andrew Lowy, and Pamela Itkin-Ansari. "Abstract B48: A novel high throughput screening platform identifies statins as inducers of basic Helix-Loop-Helix activity, p21 and growth arrest in pancreatic cancer cell and patient derived xenograft lines." In Abstracts: AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; May 12-15, 2016; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.panca16-b48.
Повний текст джерелаFebriana, Poppy, Isnaini Rodiyah, and Wiwik Sulistiyowati. "Implementation of Information and Communication Technology to Improve Product Quality and Partnerships with The Quadruple Helix Method Approach." In International Conference on Emerging Media, and Social Science. EAI, 2019. http://dx.doi.org/10.4108/eai.7-12-2018.2281802.
Повний текст джерелаYoshizumi, K., M. Kohda, and J. Nitta. "Gate Controlled Switching between Two Different Persistent Spin Helix States and Determination of Dresselhaus Spin-orbit Interaction Parameter." In 2016 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2016. http://dx.doi.org/10.7567/ssdm.2016.ps-12-01.
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