Дисертації з теми "110903 Central Nervous System"
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Ribeiro, Natalia. "Ação da vasopressina no núcleo paraventricular do hipotálamo sobre as alterações na atividade simpática induzidas por hiperosmolaridade." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-23052014-110906/.
Повний текст джерелаDiverse studies demonstrated that osmorality increase is able of causing simpatoexcitação and increase in arterial pressure, with paraventricular hypothalamic nucleus (PVN) involved in this response. Studies showed an role of VP modulating the activity of neurons in the PVN involved in the control of sympathetic activity. In this way, the aim of this study was to investigate the role of the vasopressina, through it\'s action in the PVN, over the alterations in the sympathetic activity induced by hiperosmolality.The results showed that bilateral microinjection of VP into the PVN is able of increase significatively the lumbar sympathetic nerve activity. Moreover, the bilateral block of the V1a receptors into PVN of animals subjected to osmotic stimulus showed a decrease in sympathetic activity not observed in normohydrated animals. Overall, the results allow to assert that the centrally released VP plays an important role in the development of the simpatoexcitation raised by increased osmolarity, through an action on the PVN neurons.
Solomon, Thomas. "Central nervous system infections in Vietnam." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340736.
Повний текст джерелаZhang, Hui. "Remyelination in the central nervous system." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8095.
Повний текст джерелаPoland, Stephen D. "Central nervous system infection with human cytomegalovirus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21311.pdf.
Повний текст джерелаBernick, Kristin Briana. "Cell biomechanics of the central nervous system." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67202.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (p. 133-153).
Traumatic brain injury (TBI) is a significant cause of death and morbidity in both the civilian and military populations. The major causes of TBI, such as motor vehicle accidents, falls, sports concussions, and ballistic and explosive blast threats for military personnel, are well established and extensively characterized; however, there remains much to be learned about the specific mechanisms of damage leading to brain injury, especially at the cellular level. In order to understand how cells of the central nervous system (CNS) respond to mechanical insults and stimuli, a combined modeling/experimental approach was adopted. A computational framework was developed to accurately model how cells deform under various macroscopically imposed loading conditions. In addition, in vitro (cell culture) models were established to investigate damage responses to biologically relevant mechanical insults. In order to develop computational models of cell response to mechanical loading, it is essential to have accurate material properties for all cells of interest. In this work, the mechanical responses of neurons and astrocytes were quantified using atomic force microscopy (AFM) at three different loading rates and under relaxation to enable characterization of both the elastic and viscous components of the cell response. AFM data were used to calibrate an eight-parameter rheological model implemented in the framework of a commercial finite element package (Abaqus). Model parameters fit to the measured responses of neurons and astrocytes provide a quantitative measure of homogenized nonlinear viscoelastic properties for each cell type. In order to ensure that the measured responses could be considered representative of cell populations in their physiological environment, cells were also grown and tested on substrates of various stiffness, with the softest substrate mimicking the stiffness of brain tissue. Results of this study showed both the morphology and measured force response of astrocytes to be significantly affected by the stiffness of their substrate, with cells becoming increasingly rounded on soft substrates. Results of simulations suggested that changes in cell morphology were able to account for the observed changes in AFM force response, without significant changes to the cell material properties. In contrast, no significant changes in cell morphology were observed for neurons. These results highlight the importance of growing cells in a biologically relevant environment when studying mechanically mediated responses, such as TBI. To address this requirement, we developed two model systems with CNS cells grown in soft, 3D gels to investigate damage arising from dynamic compressive loading and from a shock pressure wave. These damage protocols, coupled with the single cell computational models, provide a new tool set for characterizing damage mechanisms in CNS cells and for studying TBI in highly controllable in vitro conditions.
by Kristin Briana Bernick.
Ph.D.
Coutinho, Maria Ester Freitas Barbosa Pereira. "Central nervous system autoimmunity in neuropsychiatric disorders." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:389fb830-4b4e-4201-9965-19acb2c63ff3.
Повний текст джерелаHüppi, Petra Susan. "Serum antibodies to central nervous system antigens /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаPiani, Daniela. "Immune-mediated cytotoxicity in the central nervous system /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10423.
Повний текст джерелаLamvik, Kate K. "Central Nervous System Associations in Neurofibromatosis Type 1." Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1179426618.
Повний текст джерелаAdvisor: Dr. Elizabeth K. Schorry. Title from electronic thesis title page (viewed June 30, 2010). Includes abstract. Keywords: Neurofibromatosis type 1 (NF1); optic pathway glioma (OPG); central nervous system (CNS). Includes bibliographical references.
Suzumura, Akio. "Microglia : Immunoregulatory cells in the central nervous system." Nagoya University School of Medicine, 2002. http://hdl.handle.net/2237/5375.
Повний текст джерелаLee, Yong Beom. "Cytokine network in the human central nervous system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0022/NQ38925.pdf.
Повний текст джерелаWeber, Wilhelm Evert Jacob. "Cellular auto-immunity in central nervous system disease." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5594.
Повний текст джерелаJackson, Johanna Sara. "Stem cell tracking in the central nervous system." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446551.
Повний текст джерелаBell, Michael David. "Factors regulating inflammation in the central nervous system." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308694.
Повний текст джерелаSmith, Imogen. "Cannabinoid receptor signalling in the central nervous system." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553656.
Повний текст джерелаSussman, Jonathan David. "Glial lineages in the adult central nervous system." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625026.
Повний текст джерелаMcQuaid, Stephen. "Measles virus infection of the central nervous system." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287361.
Повний текст джерелаDavies, M. "5-hydroxytryptamine receptors in the central nervous system." Thesis, Bucks New University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382505.
Повний текст джерелаPanni, Moeen. "Neuron-target interactions in the central nervous system." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337889.
Повний текст джерелаStaley, Kristina. "Targeting gene expression to the central nervous system." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319537.
Повний текст джерелаGaltrey, Clare Margaret. "Central nervous system plasticity and peripheral nerve repair." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614254.
Повний текст джерелаRoberts, Malcolm Ian. "Death receptor 3 in the central nervous system." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615645.
Повний текст джерелаRist, Julia Maria. "Rejuvenating remyelination in the ageing central nervous system." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608517.
Повний текст джерелаAlmeida, Rafael. "Axon-glia interactions during central nervous system myelination." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21038.
Повний текст джерелаGifford, Andrew Neal. "Catecholaminergic neurotransmission in the insect central nervous system." Thesis, University of St Andrews, 1989. http://hdl.handle.net/10023/15042.
Повний текст джерелаSmorodska, O., I. Shandyba, P. Bileckiy, Роман Андрійович Москаленко, Роман Андреевич Москаленко, Roman Andriiovych Moskalenko, Андрій Миколайович Лобода, et al. "Affection of central nervous system in MELAS syndrome." Thesis, Karger Publishers, 2017. http://essuir.sumdu.edu.ua/handle/123456789/65352.
Повний текст джерелаWheeler, Natalie A. "Autotaxin in Central Nervous System Development and Disease." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4104.
Повний текст джерелаZhang, Xiaochun. "Involvement of neuroinflammation in models of neurodegeneration." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1663059561&sid=3&Fmt=2&clientId=18949&RQT=309&VName=PQD.
Повний текст джерелаEckert, Bodil. "Hypoglycaemia studies on central and peripheral nerve function /." Lund : Dept. of Internal Medicine, University of Lund, 1998. http://catalog.hathitrust.org/api/volumes/oclc/57426099.html.
Повний текст джерелаFoster, Michelle Tranace. "Central nervous system regulation of fat cell lipid mobilization the role of the sympathetic nervous system /." restricted, 2005. http://etd.gsu.edu/theses/available/etd-11162005-154631/.
Повний текст джерелаTimothy Bartness, committee chair; Elliott Albers, Ruth Harris , Sarah Pallas, committee members. Electronic text (181 p. : ill.)) : digital, PDF file. Description based on contents viewed July 17, 2007. Includes bibliographical references (p. 148-181).
Foster, Michelle Tranace. "Central Nervous System Regulation of Fat Cell Lipid Mobilization: The Role of the Sympathetic Nervous System." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/2.
Повний текст джерелаTep-Cullison, Chhavy R. "Distinct roles of p75 regulation on myelination in the peripheral nervous system and central nervous system." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299179635.
Повний текст джерелаAkers, Stephen Matthew. "Modeling central nervous system involvement in acute lymphoblastic leukemia." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/11227.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains x, 102 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
Zhang, Fan. "Modulation of genomic expression in the central nervous system." Doctoral thesis, Universite Libre de Bruxelles, 1997. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212219.
Повний текст джерелаMabon, Joy. "Strategies to reduce inflammation in the central nervous system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ39851.pdf.
Повний текст джерелаLyng, Eric E. Bottiglieri Teodoro. "Gamma Hydroxybutyrate (GHB) : mechanisms of central nervous system toxicity /." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4211.
Повний текст джерелаStromnes, Ingunn Margarete. "T cell determinants of central nervous system autoimmune disease /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8333.
Повний текст джерелаFundytus, Marian Elaine. "Central nervous system and peripheral signs of opioid abstinence." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56639.
Повний текст джерелаSystemic administration of M3G alone and in combination with morphine produced no withdrawal-like behaviors. However, when these drugs were given centrally, withdrawal-like behaviors were observed in conjunction with seizures. The seizures were not attenuated by naloxone (but were alleviated by an anti-convulsant), indicating that they were not mediated by opioid receptors. The behaviors resembled those seen by previous investigators following high doses of morphine. The results suggest that M3G may play a role in the toxic effects of high doses of morphine.
Goudreau, Guy. "Transgenic models of retrovirus-mediated central nervous system diseases." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39908.
Повний текст джерелаVidyadaran, Sharmili. "Neuroprotective properties of HSP27 in the central nervous system." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424392.
Повний текст джерелаMatyszak, M. K. "Immune mediated inflammatory responses in the central nervous system." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334846.
Повний текст джерелаTran, Thi Hong Chau. "Clinical and pathological aspects of central nervous system infection." Thesis, Open University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578010.
Повний текст джерелаIves, N. K. "Bilirubin transport and toxicity in the central nervous system." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604974.
Повний текст джерелаRuddick, Jon Paul. "Characterisation of ABCG transporters in the central nervous system." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289547.
Повний текст джерелаRhodes, Katherine Emily. "Oligodendrocyte precursor cells in the injured central nervous system." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620605.
Повний текст джерелаChrist, Andreas Fridolin. "High resolution mechanical mapping of central nervous system tissue." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609861.
Повний текст джерелаde, Bettignies A. S. "Wnt/Fz interactions in the developing central nervous system." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444543/.
Повний текст джерелаLiu, Jingshan. "Hyperhomocysteinemia and Inflammatory Profile in the Central Nervous System." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/133428.
Повний текст джерелаM.S.
Homocysteine, an intermediate metabolite biosynthesized from the methionine cycle, is a homologue of cysteine. Homocysteine differs from cysteine by an additional methylene group, which makes it more reactive. Elevated homocysteine level is a risk factor for cardiovascular disease and cerebrovascular disease, brain atrophy, neurodegenerative diseases and cognitive dysfunctions. Recent studies suggest a bi-directional relationship between homocysteine levels and immune-inflammatory activation. Our studies sought to determine if hyperhomocysteinemia affects cell infiltrates in the Central Nervous System (CNS). Inflammatory monocytes recruitment into the CNS and microglia proliferation have been shown in several inflammatory models, and Ly-6Chi CCR2+ monocytes have been shown to be the precursor for microglia. Based on these findings, we hypothesized that hyperhomocysteinemia (HHcy) would alter CNS infiltrate composition. We investigated whether HHcy affected the total mononuclear cells composition in the CNS. We also determined whether HHcy altered the inflammatory monocyte subsets composition in the CNS. In order to determine the effects of HHcy in the CNS mononuclear cells composition, we genotyped the mice, and isolated mononuclear cells from the CNS using percoll gradient method. Then we simultaneously stained the cells with three antibodies, PE-labeled anti-mouse CD11b, PE-Cy5-labeled anti-mouse CD45, and FITC-labeled anti-mouse Ly-6C and analyzed the samples by flow cytometry method. HHcy made no difference in the percentage of lymphocytes, infiltrating monocytes and microglia in the total CNS mononuclear cells, but within infiltrating monocytes, HHcy decreased Ly-6Clo and increased Ly-6Chi subsets. These findings demonstrate that HHcy has effects on the CNS mononuclear cell composition. In summary, HHcy decreased Ly-6Clo and increased Ly-6Chi subsets of infiltrating monocytes in the CNS. There is a potential role of HHcy in increasing inflammatory monocytes infiltration.
Temple University--Theses
Freeman, Sean. "Mechanisms of central nervous system nodes of Ranvier assembly." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066425/document.
Повний текст джерелаThe clustering of sodium channels (Nav) at the nodes of Ranvier is an important step in permitting rapid saltatory conduction along myelinated axons. Nodal assembly is neuron-glia dependent, mediated by myelinating oligodendrocytes of the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS). While the mechanisms of nodal assembly are currently best characterized in the PNS, cellular and molecular mechanisms underlying their assembly in the CNS are only partially understood. In the core of my PhD dissertation, I focused on the early developmental steps of nodal protein clustering in the CNS and show that clusters of nodal proteins, called prenodes, are detected before myelination along GABAergic axons in hippocampal neuron-glia cultures and also in the developing rodent hippocampus. Prenodal clustering requires extrinsic oligodendroglial secreted proteinaceous factors, and also the intrinsic axonal cytoskeletal scaffolding protein ankyrinG. Furthermore, the transition of sodium channels isoforms is tightly regulated along GABAergic axons during development, but this transition is lost in the absence of the physical presence of glial cells. Lastly, prenodes increase axonal conduction by a factor of 1.5x, independently of myelination and axonal caliber. Taken together, these results further our understanding of CNS nodes of Ranvier assembly mechanisms and the developmental function of nodal clustering prior to myelin ensheathment. While conduction velocity along axons has long been thought to mostly rely on the insulating properties of myelin, these results may shed light on a new concept of axonal conduction in the absence of myelination
Chen, Vivian Susan Matsushima Glenn K. "Immune mediators of central nervous system demyelination and remyelination." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1844.
Повний текст джерелаTitle from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctorate of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.