Дисертації з теми "110902 Cellular Nervous System"
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Weber, Wilhelm Evert Jacob. "Cellular auto-immunity in central nervous system disease." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5594.
Повний текст джерелаRoshan, Payam. "Cellular basis of inflammation in the enteric nervous system." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26759.
Повний текст джерелаFord, Melanie. "Cellular prion protein expression in the mouse." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249698.
Повний текст джерелаBalaskas, Christos. "Cellular development of the enteric nervous system in the chick embryo." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267801.
Повний текст джерелаBogni, Silvia. "Molecular and cellular analysis of the enteric nervous system in vivo." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402166.
Повний текст джерелаSchuldt, Alison Jean. "The generation of cellular diversity in the Drosophila central nervous system." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624291.
Повний текст джерелаWILLIAMS, JON. "EFFECTS OF LOSS OF NF1 GENE ON PERIPHERAL NERVOUS SYSTEM PROGENITORS AND TUMORIGENESIS." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212181112.
Повний текст джерелаPliego-Rivero, Francisco Bernardo. "Thy-1 : cellular compartmentalization during development and participation in signal transduction." Thesis, Open University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358073.
Повний текст джерелаFranceschini, Isabelle A. "Cellular and molecular studies on olfactory bulb ensheathing cells." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301803.
Повний текст джерелаBrownlee, David Joseph Acheson. "Putative neurotransmitters in selected helminth parasites : cellular and subcellular localisation." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296822.
Повний текст джерелаCooper, Jason Christian Todd. "Agmatine, Decarboxylated Arginine, is a Transepithelial Signal to the Enteric Nervous System." Thesis, Mississippi College, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10686492.
Повний текст джерелаRecent advances regarding commensals in the gastrointestinal tract point to an intimate “accessory” organ status. To study the cross-talk that an accessory organ must have, the Piletz laboratory began in 2014 developing a three-dimensional (3D) in vitro co-culture model system, whereby two differentiated cell lines are juxtaposed along with “luminal” contents. The model uses differentiated C2BBe1 cell line enterocytes grown to confluency on polycarbonate filters with 0.4 µm pores over-layered atop SH-SY5Y cell line neurons to study cross-talk from either the lumen-side or the neuron-side. The focus is on an endogenous molecule, agmatine (1-amino-4-guanidobutane), made by gut bacteria at millimolar concentrations in the mucosa of the small intestine—yet in the brain known to be a neurotransmitter. Starting with each individual cell line in standard mono-cultures, agmatine was added at varying doses and varying times to replicate what is essentially dogma to the agmatine field, that of being anti-proliferative to all mammalian cells. Above 1 mM agmatine, the predicted anti-proliferative response was realized as a non-toxic, non-divisional state sustained for at least 4 days from single dosing. Moving to the 3D co-culture system, wherein the C2BBe1 cells were differentiated as per high transepithelial electrical resistance (TEER) over a 24-hour equilibration period, it was expected that agmatine would again be anti-proliferative. Yet, apical agmatine appeared to exert a pro-proliferative effect starting as low as 0.002 mM. A parallel decline in metabolism per SH-SY5Y cell was found using the color dye reaction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). It was therefore hypothesized that apical agmatine had caused the C2BBe1 cells to secrete a growth signal(s) impacting the underlying SH-SY5Y cells; and to test this, conditioned basal media collected from just C2BBe1 cells grown 4 days in the presence of apical 2 mM agmatine was taken to replace the media of naïve SH-SY5Y cells growing in log phase mono-cultures. The expectation was that growth factors would be carried over, but to the contrary, an anti-proliferative response emerged from the conditioned media, mirroring the earlier studies with agmatine in mono-cultures. Cellular lysates were also prepared from treated cells exposed for 24 h to 2 mM agmatine, and these were probed on immune-blots to assess if any of 32 common receptor tyrosine kinases had phosphorylated /activated post-addition of apical mM agmatine. No evidence was obtained that agmatine (mM apical) had elicited such flags of cell activation. Next, the 3D co-culture condition was re-run for longer periods and with more controls, and from this came the realization that the model had hidden the existence of an anti-proliferative response from the C2BBe1 cells before agmatine was even added. In short, the starting hypothesis was disproven, but in doing so it was realized that micromolar apical agmatine is able to rejuvenate a cytostasis rendered by the C2BBe1 co-culturing. Two fundamentally different mechanisms must be invoked by agmatine, because the concentrations of agmatine at which these two processes occurred were 500-fold different (0.002 mM for the reversal of cytostasis vs. 1 mM for anti-proliferative, respectively). In summary, any microbial dysbiosis involving agmatine-producing bacteria is likely to act through two molecular signaling mechanisms from the “accessory” organ bacteria to enteric nervous system.
Etheredge, Jack. "Transcriptional profiling of Drosophila larval ventral nervous system hemilineages." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/270548.
Повний текст джерелаHall, Deborah Jean. "Cytokines and their inhibition within the central nervous system in chronic relasping experimental allergic encephalomyelitis." Thesis, University of York, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238710.
Повний текст джерелаde, Lange Anja. "Exploring molecular and cellular mechanisms underlying seizures in neurocysticercosis." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33597.
Повний текст джерелаTam, Chun-yat, and 譚俊逸. "Genetic interaction between Patched1 and Sox10 in enteric nervous system development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/211149.
Повний текст джерелаpublished_or_final_version
Surgery
Master
Master of Philosophy
Sjöblom, Markus. "The duodenal mucosal bicarbonate secretion : role of melatonin in neurohumoral control and cellular signaling /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. {[distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3521.
Повний текст джерелаEade, Kevin Thomas. "Subsets of developmental transcription networks maintain cellular subtype identity in the mature nervous system." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/40717.
Повний текст джерелаRao, Rohit R. "The Microenvironment as a Regulator of Nervous System Development, Brain Tumor Growth and Treatment Resistance." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1624917824334193.
Повний текст джерелаOoi, Felicia Kye-Lyn. "Uncovering how the nervous system controls the cellular stress response in the metazoan Caenorhabditis elegans." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6236.
Повний текст джерелаRavula, Surendra Kumar. "A Multielectrode Microcompartment Platform for Signal Transduction in the Nervous System." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/11527.
Повний текст джерелаKelps, Kristen. "Molecular and Cellular Characterization of Dopamine Neuron Stimulating Peptides." UKnowledge, 2013. http://uknowledge.uky.edu/neurobio_etds/6.
Повний текст джерелаMay, Verena Elisabeth Luise [Verfasser], and Jürgen [Akademischer Betreuer] Winkler. "Cellular Plasticity within the Central Nervous System of Synucleinopathies / Verena Elisabeth Luise May. Betreuer: Jürgen Winkler." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2013. http://d-nb.info/1035540703/34.
Повний текст джерелаSmith, Nicholas James Chapman. "Neuronopathic Gaucher disease : the pathobiological effects of glucosylsphingosine upon cellular actin within the central nervous system." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648776.
Повний текст джерелаBoone, Jason Nathaniel 1976. "Characterization of novel neural stem cell populations in the Drosophila central nervous system." Thesis, University of Oregon, 2008. http://hdl.handle.net/1794/8160.
Повний текст джерелаNeuroblasts are the neural stem cells of the Drosophlia central nervous system. They are large cells that divide asymmetrically to renew another neuroblast and generate a smaller ganglion mother cell (gmc) that will divide once to produce two neurons. Combining genetic lineage tracing experiments with cell fate markers I isolated two separate neural stem cell populations with distinct locations and cellular behaviors in the larval brain. In my first chapter I introduce the central nervous system of Drosophila and in the next two sections of chapter I, I introduce the development of the optic lobe and central brain, two separate structures of the central nervous system. In my second chapter I characterize the lineage relationship of cells within the developing larval optic lobe and use cell fate markers to determine the identity of these cells. Next I examine the effect of spindle orientation on cell fate within epithelial cells of the optic lobe. In my third chapter I characterize another novel neural stem cell lineage in the larval brain containing GMCs with greater proliferation potential than a "canonical" GMC, and I term these, transit amplifying gmcs (TA-GMCs). Further I show that the parent neuroblast of these novel TA-GMCs does not asymmetrically segregate the fate determinant Prospero (Pros) thereby producing a GMC with greater proliferation potential. Finally I show that TA-GMCs do asymmetrically segregate the fate determinant Pros, divide slowly and give rise to up to 10 neurons which normal gmcs never do. In my fourth chapter I show preliminary work on the characterization of a mutation that causes excessive production of neuroblasts specifically in novel TA-GMC lineages. These findings reveal novel neural stem cell lineages, patterns of asymmetric cell division and patterns of neurogenesis that could aid in our understanding of neural stem cell biology and tumorogenesis. This dissertation includes both my previously published and my co-authored materials.
Adviser: Chris Doe
Zayas, Ventura Ricardo Manuel. "Nitric oxide/cyclic GMP signaling in the central nervous system of Manduca sexta larvae /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2003.
Знайти повний текст джерелаAdviser: Barry A. Trimmer. Submitted to the Dept. of Biology. Includes bibliographical references (leaves 147-164). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
Etter, Paul Dezso. "Genomic Approaches to Identifying Transcriptional Targets of AP-1, CREB and JNK Signaling in the Nervous System of Drosophila melanogaster." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1365%5F1%5Fm.pdf&type=application/pdf.
Повний текст джерелаSindi, Ghadir A. "Effects of Paternal Obesity on The Central Nervous System Reward Circuitry in Offspring." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470232740.
Повний текст джерелаStarck, Laurent [Verfasser], and V. Prasad [Akademischer Betreuer] Shastri. "The new roles of cellular mechanotransduction in mediating astrocyte phenotype and function in the central nervous system." Freiburg : Universität, 2020. http://d-nb.info/1239556365/34.
Повний текст джерелаZhang, Yi. "Studies of heparanase (HPA) gene expression, cellular localization and functions in neural tissues of the rat." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634061.
Повний текст джерелаMuthukumar, Allie. "Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/745.
Повний текст джерелаMuthukumar, Allie. "Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/745.
Повний текст джерелаBruch, William. "GROUP I METABOTROPIC GLUTAMATE RECEPTORS ON SELECTIVE CELLULAR SUBTYPES IN EPILEPTOGENIC MALFORMED CORTEX." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/378.
Повний текст джерелаZhang, Yi, and 張怡. "Studies of heparanase (HPA) gene expression, cellular localization andfunctions in neural tissues of the rat." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634061.
Повний текст джерелаMydlarski, Marc Bernard. "Role of the cellular stress response in the biogenesis of redox-active astrocytic inclusions in the aging nervous system." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39970.
Повний текст джерелаWe determined that the accumulation of astrocytic inclusions in cysteamine-treated rat glial cultures occurs in the context of an antecedent cellular stress response characterized by (i) the upregulation of heat shock proteins (HSP) 27, 72, 90, ubiquitin and heme oxygenase-1, and (ii) enhanced resistance of cysteamine-stressed astroglia to subsequent oxidative injury. Furthermore, multiple injections of cysteamine or estradiol valerate in adult male rats induced robust overexpression of stress proteins and an accretion of identical peroxidase-positive granules in GFAP-positive astroglia. Both in situ and in cysteamine-treated cultures, HSP27, ubiquitin, glucose-regulated protein 94 and to a lesser extent, HSP72 (but not HSP90 or $ alpha$B-crystallin) exhibited immunolocalization to these astrocytic "stress" inclusions. We observed that exogenous $ rm H sb2O sb2$ induces identical inclusions in cultured astroglia and that cysteamine-derived $ rm H sb2O sb2$ promotes lipid peroxidation in isolated astroglial mitochondria. These data indicate that sustained oxidative stress may represent a "final common pathway" leading to the transformation of normal mitochondria to peroxidase-positive astrocytic inclusions in the aging nervous system.
The metal-dependent peroxidase activity of these glial inclusions has been shown to oxidize dopamine and other catechols to neurotoxic free radicals in vitro, implicating these cells in the pathogenesis of parkinsonism and other free radical-related neurodegenerations. Since peroxidase-positive astroglia have been identified in aging human striatum, the findings presented here suggest that antioxidant therapy coupled with pharmacological inhibition of metal sequestration by "stressed" astroglial mitochondria may prove useful in the management of Parkinson's disease and other age-associated neurodegenerative afflictions.
Ransom, Brian Lyn. "Epidermal growth factor dependent regulation of drosophila nervous system development along the dorso-ventral axis." Thesis, Kansas State University, 2011. http://hdl.handle.net/2097/8772.
Повний текст джерелаDepartment of Biology
Tonia L. Von Ohlen
The Drosophila embryonic nervous system develops from an array of neural precursor cells called, neuroblasts. These neuroblasts give rise to all the cell types that populate the mature central nervous system (CNS). The CNS originates from a bilateraly symmetric neurectoderm that is subdivided into three domains along the dorso-ventral (DV) axis. One of these domains is defined by the expression of the Homeodomain protein ventral nervous system defective (vnd). Regulation of neuroblast designation is very precise and controlled. Extensive research has been done on neuroblast formation along the anteroposterior axis, most of which indicates that neuroblast selection within a cluster of neurectodermal cells is controlled by segmentation genes. However, much more research is required to elucidate the function of genes along the DV axis. Early studies indicate that vnd is required for neuroblast formation in the ventral column. Here, we show that vnd function, but not expression, is dependent on MAPK activity downstream of Drosophila EGF-R (DER). Specifically, we show that vnd activity is eliminated in EGF-R mutant embryos in a stage specific manner by evaluating vnd’s ability to inhibit intermediate neuroblast defective (ind), muscle segment homeobox (msh), and the newly identified neural tube development player, neu3. Finally, we show that DER functionality in the ventral column is entirely dependent on the processing protein rhomboid (rho) in later stage embryos.
Caprariello, Andrew Vincent. "Cytoarchitectural Defects Secondary To Experimentally Induced Oligodendrocyte Death In The Adult And Developing Central Nervous System." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1346859526.
Повний текст джерелаChidambaram, Archana. "WILMS’ TUMOR-1 (WT1) PROTEIN EXPRESSION IN GLIOMA CELLS ACTUATES CELLULAR INVASIVENESS- IDENTIFYING ITS TARGET GENES." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2454.
Повний текст джерелаDiao, Tiemei, and 刁鈇梅. "The gene expression, binding properties and intracelular signal transduction of kappa-opioid receptor in non-neuronal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31220770.
Повний текст джерелаPoon, Hiu-ching. "A study of the regulatory roles of Hedgehog in the enteric nervous system development by the conditional knockout of Patched1 enteric gene in the enteric neural crest cells." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841604.
Повний текст джерелаPan, Feng. "Understanding Ten-Eleven Translocation-2 in Hematological and Nervous Systems." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1925.
Повний текст джерелаGlossop, Nicholas Robert John. "The developmental assembly of sensory axon arrays in the nervous system of Drosophila melanogaster : a combined cellular, genetic and molecular study." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241942.
Повний текст джерелаChou, Chiu-wen, and 周秋雯. "A study of the expression of NF-kB in central nervous system of rats with neuropathic pain." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44902542.
Повний текст джерелаEllis, Rebecca Catherine. "Characterization of cathepsin b mrna and protein expression, enzymatic activity and cellular localization following contusion spinal cord injury in rats." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0007160.
Повний текст джерелаTypescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.
Holler, Christopher J. "THE CELLULAR NUCLEIC ACID BINDING PROTEIN REGULATES THE ALZHEIMER’S DISEASE β-SECRETASE PROTEIN BACE1". UKnowledge, 2012. http://uknowledge.uky.edu/biochem_etds/12.
Повний текст джерелаOliver, Devyn. "Constructing and Maintaining the Nervous System: Molecular Insights Underlying Neuronal Architecture, Synaptic Development, and Synaptic Maintenance Using C. elegans." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1123.
Повний текст джерелаPoon, Hiu-ching, and 潘曉澄. "A study of the regulatory roles of Hedgehog in the enteric nervous system development by the conditional knockout of Patched1 entericgene in the enteric neural crest cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841604.
Повний текст джерелаSmith, Angeline Gabriel. "Cellular and molecular studies upon repair and regeneration within the nervous system of asexually dividing tetrathyridia of mesocestoides vogae (Syn. M. corti)." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.232840.
Повний текст джерелаTischbein, Maeve. "FUS and Excitotoxicity Cross Paths in ALS: New Insights into Cellular Stress and Disease." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/990.
Повний текст джерелаHebbar, Sarita. "Patterning the DLM innervation in Drosophila: cellular interactions and molecular mechanisms." Miami University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=miami1123793870.
Повний текст джерелаDallimore, Elizabeth Jane. "Molecular and cellular characteristics of early vs late born retinal ganglion cells." University of Western Australia. School of Anatomy and Human Biology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0138.
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