Дисертації з теми "069999 Biological Sciences not elsewhere classified"
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McLarnon-Riches, Christian James. "The use of lipid profiles from immobilised Selenastrum capricornutum in the biological surveillance of freshwaters." Thesis, University of Central Lancashire, 2000. http://clok.uclan.ac.uk/19764/.
Повний текст джерелаLu, Chen. "Expression profile of multidrug resistance genes and proteins in cancerous and stem cells." Thesis, University of Central Lancashire, 2008. http://clok.uclan.ac.uk/19754/.
Повний текст джерелаWoodruff, Kim Therese. "The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)." Thesis, University of Central Lancashire, 2004. http://clok.uclan.ac.uk/20248/.
Повний текст джерелаChandranath, Swaminathan Irwin. "Comparitive activities and mechanisms of action of three novel antiulcer agents." Thesis, University of Central Lancashire, 2000. http://clok.uclan.ac.uk/21028/.
Повний текст джерелаHigginson, James Matthew. "Signal transduction pathways involved in skeletal muscle fibre type regulation." Thesis, University of Central Lancashire, 2003. http://clok.uclan.ac.uk/21870/.
Повний текст джерелаBian, Lei. "An in vitro antimicrobial and safety study of Lactobacillus reuteri DPC16 for validation of probiotic concept : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Biotechnology at Massey University, Auckland, New Zealand." Massey University, 2008. http://hdl.handle.net/10179/830.
Повний текст джерелаDenny, Kirsty Marie. "The diet of moreporks (Ninox novaeseelandiae) in relation to prey availability, and their roost site characteristics and breeding success on Ponui Island, Hauraki Gulf, New Zealand : a thesis presented in fulfilment of the requirements for the degree of Master of Science in Ecology at Massey University, Albany, New Zealand." Massey University, 2009. http://hdl.handle.net/10179/1213.
Повний текст джерелаBrown, Samuel David James. "Molecular systematics and colour variation of Carpophilus species (Coleoptera: Nitidulidae) of the South Pacific." Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1430.
Повний текст джерелаMuir, Matthew Stewart. "Proteomics of the ovine cataract." Diss., Lincoln University, 2008. http://hdl.handle.net/10182/792.
Повний текст джерела(5931173), Jessica Merkling. "Development of an Environmental DNA Assay for Eastern Massasauga." Thesis, 2019.
Знайти повний текст джерела(8815928), Samantha Jurecki. "APPLICATION AND VALIDATION OF THE EDNA-METABARCODED MIFISH/MITOFISH PIPELINE FOR ASSESSMENT OF NATIVE AND NON-NATIVE FISH COMMUNITIES OF LAKE MICHIGAN." Thesis, 2020.
Знайти повний текст джерела(8102609), Kara A. Negrini. "Novel Extrinsic and Intrinsic Factors Mediating Osteoarthritis." Thesis, 2020.
Знайти повний текст джерелаOsteoarthritis (OA) is a leading cause of disability globally, with higher incidence in older people and lower socioeconomic status populations. The challenges health care systems face with management of the disease highlights the importance of OA research. Many studies examine possible risk factors of knee and hip OA including obesity, smoking, and alcohol consumption. Findings support that while obesity increases risk of knee OA, smoking is not a major risk factor. These extrinsic factors are, however, associated with lower socioeconomic status, and also with anxiety and depression disorders. Up to 30% of patients with chronic knee OA have described psychological stress and decreased quality of life due to debilitating pain, but the effects of psychological stress on development of knee OA has not been described.
At the cellular level, mechanosensitive cation channels in cartilage and bone, are involved with OA, but studies looking specifically at synovium and joint capsule are limited. Transient receptor potential (TRP) channels are upregulated in joint capsule in end-stage primary shoulder OA. We were unable to identify any previous studies evaluating Piezo channel expression in musculoskeletal soft tissues, but Piezo channel antagonism reduces chondrocyte death after mechanical injury. These findings suggest channels may help regulate joint responses to repetitive loading during training or work while also contributing to protective mechanisms within the musculoskeletal system. The overall objective of this research was to investigate factors that impact OA development or the disease phenotype. Two studies evaluated the following aims: 1) demonstrate the influence of chronic psychological stress on knee OA and overall systemic health, and 2) characterize the role of mechanosensitive channels in the joint capsule in OA. The first study used a mouse chronic social defeat model paired with destabilization of the medial meniscus (DMM) surgery to create a social stress scenario during OA development. We hypothesized chronic social defeat would exacerbate knee OA structural changes and systemic inflammation. The second study aimed to explore the role of mechanosensitive channels in joint capsule during OA development in the equine. Immunohistochemistry was performed on forelimb fetlock joint capsule from horses with varying degrees of lameness to first identify TRP and Piezo channel expression. Next, fibroblasts were isolated from the tissue to determine channel activity. We hypothesized that TRP and Piezo channels are required for normal homeostasis, but are dysregulated in OA and dysregulation contributes to fibrosis of the joint capsule. Joint capsule fibrosis leads to joint stiffening and reduced range of motion, two of the cardinal signs of OA.
The results of the first study showed OA was induced to a similar extent in both groups of mice that underwent DMM surgery. While anxiety- and depressive-like behaviors were exhibited by mice that underwent chronic social defeat episodes, unexpectedly, the majority of systemic inflammatory markers were not worse in mice with DMM and chronic social defeat compared to DMM alone. We were also able to show TRP and Piezo channel expression in one normal dorsal and palmar fetlock joint capsule sample, however, COVID-19 prevented further investigation. With our results we were able to conclude that while chronic social stress influences development of OA, in the current experiments, neither systemic inflammation nor structural signs of knee OA were worse with chronic social stress. We hope that exploration of OA through these two studies will help us understand how the disease contributes to overall systemic dysfunction while also providing a baseline for future development of TRP and Piezo channel modulators to prevent joint pathologies.
(9183593), Noah S. Feldman. "Does environmental variability explain male parental care in a burying beetle?" Thesis, 2020.
Знайти повний текст джерелаBenny, Athol Graeme. "An integrated process for the recovery of clinically significant trace proteins from human plasma." 1990. http://hdl.handle.net/2292/2157.
Повний текст джерела(5930438), Yi Yang. "THE THROMBOSIS PATHWAY PROMOTES PANCREATIC CANCER GROWTH AND METASTASIS." Thesis, 2019.
Знайти повний текст джерелаPancreatic ductal adenocarcinoma (PDAC) is an incredibly lethal disease with a 5-year survival rate of less than 8 percent in the United States due to a lack of viable treatment options. The failures of chemo- and radiotherapies have been linked to the heterogeneous nature of the tumor microenvironment which forms a hypovascular, immunosuppressive and high coagulation activity tissue. Indeed, PDAC patients have one of the highest rates of thrombosis complications among all cancer types. The expression of two key coagulation factors, Tissue Factor (TF) and Protease Activated Receptor 1 (PAR-1), have been associated with poor patient prognosis and aggressive cancer progression. However, the molecular roles/mechanisms of TF and PAR-1 in PDAC progression are not known. To establish how clotting factors (PAR-1, TF) influence PDAC tumor progression, I utilized a genetically modified mouse model (KPC) where KRasG12D and TRP53R172H mutations were specifically introduced into mouse pancreas acinar cells to initiate PDAC progression. Multiple primary mouse PDAC cell lines were generated and characterized. TF and PAR-1 were highly expressed in primary KPC pancreatic lesions, in PDAC tumors, and in KPC-derived cell lines, an expression profile that is also observed in PDAC patient biopsies. In allograft studies, tumor growth and metastatic potential were significantly diminished by shRNA reduction of TF or PAR-1 in cancer cells or by genetic or pharmacological reduction of the coagulation zymogen prothrombin in mice. Notably, PAR-1 deleted KPC cells (KPC-Par-1KO) failed to generate sizable tumors; a phenotype completely rescued by restoration of PAR-1 expression. To test the significance of targeting PAR-1 in a clinical setting, PAR-1 expression was withdrawn from established tumors to mimic a potential inhibitory effect of PAR-1 on solid PDAC tumors. Removal of PAR-1 from tumors (11 days post injection) yielded a diverse effect on tumor growth which can be categorized into (i) a decline in tumor growth; (ii) continued tumor growth; and (iii) stagnant tumor growth. Immunohistochemistry analysis of KPC2 shCon vs. shPar-1 subcutaneous allograft tumor samples revealed a massive immune cell infiltration in KPC2 shPAR-1 tumors when compared to KPC2 shCon control tumors. Accordingly, KPC-Par-1KO cells failed to form tumors in immune-competent mice but displayed robust tumor growth in immune-compromised NSG mice, providing the first evidence of a PAR-1 mediated tumor immune evasion pathway operating in PDAC.
Together, these results demonstrate that PDAC disease is driven by activation of the coagulation system through tumor cell-derived TF, circulating prothrombin, and tumor cell-derived PAR-1. These studies also highlight a novel mechanism by which thrombin/PAR-1-mediated tumor growth involves suppression of anti-tumor immunity in the tumor microenvironment.
(10716291), Alison Jenele Meeth. "FORAGING ECOLOGY OF NESTING GREEN, OLIVE RIDLEY, AND LEATHERBACK TURTLES FROM NORTHWEST COSTA RICA." Thesis, 2021.
Знайти повний текст джерела(11198013), Kevin Wee. "Creation, deconstruction, and evaluation of a biochemistry animation about the role of the actin cytoskeleton in cell motility." Thesis, 2021.
Знайти повний текст джерелаExternal representations (ERs) used in science education are multimodal ensembles consisting of design elements to convey educational meanings to the audience. As an example of a dynamic ER, an animation presenting its content features (i.e., scientific concepts) via varying the feature’s depiction over time. A production team invited the dissertation author to inspect their creation of a biochemistry animation about the role of the actin cytoskeleton in cell motility and the animation’s implication on learning. To address this, the author developed a four-step methodology entitled the Multimodal Variation Analysis of Dynamic External Representations (MVADER) that deconstructs the animation’s content and design to inspect how each content feature is conveyed via the animation’s design elements.
This dissertation research investigated the actin animation’s educational value and the MVADER’s utility in animation evaluation. The research design was guided by descriptive case study methodology and an integrated framework consisting of the variation theory, multimodal analysis, and visual analytics. As stated above, the animation was analyzed using MVADER. The development of the actin animation and the content features the production team members intended to convey via the animation were studied by analyzing the communication records between the members, observing the team meetings, and interviewing the members individually. Furthermore, students’ learning experiences from watching the animation were examined via semi-structured interviews coupled with post- storyboarding. Moreover, the instructions of MVADER and its applications in studying the actin animation were reviewed to determine the MVADER’s usefulness as an animation evaluation tool.
Findings of this research indicate that the three educators in the production team intended the actin animation to convey forty-three content features to the undergraduate biology students. At least 50% of the student who participated in this thesis learned thirty-five of these forty-three (> 80%) features. Evidence suggests that the animation’s effectiveness to convey its features was associated with the features’ depiction time, the number of identified design elements applied to depict the features, and the features’ variation of depiction over time.
Additionally, one-third of the student participants made similar mistakes regarding two content features after watching the actin animation: the F-actin elongation and the F-actin crosslink structure in lamellipodia. The analysis reveals the animation’s potential design flaws that might have contributed to these common misconceptions. Furthermore, two disruptors to the creation process and the educational value of the actin animation were identified: the vagueness of the learning goals and the designer’s placement of the animation’s beauty over its reach to the learning goals. The vagueness of the learning goals hampered the narration scripting process. On the other hand, the designer’s prioritization of the animation’s aesthetic led to the inclusion of a “beauty shot” in the animation that caused students’ confusion.
MVADER was used to examine the content, design, and their relationships in the actin animation at multiple aspects and granularities. The result of MVADER was compared with the students’ learning outcomes from watching the animation to identify the characteristics of content’s depiction that were constructive and disruptive to learning. These findings led to several practical recommendations to teach using the actin animation and create educational ERs.
To conclude, this dissertation discloses the connections between the creation process, the content and design, and the educational implication of a biochemistry animation. It also introduces MVADER as a novel ER analysis tool to the education research and visualization communities. MVADER can be applied in various formats of static and dynamic ERs and beyond the disciplines of biology and chemistry.