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Статті в журналах з теми "–051"

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Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 травня 2022

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1

Jusko, Todd, Pamela Shaw, Claudia Snijder, Frank Pierik, Holger Koch, Russ Hauser, Vincent Jaddoe, et al. "O-051." Epidemiology 23 (September 2012): 1. http://dx.doi.org/10.1097/01.ede.0000416709.49302.6e.

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2

Wang, Shu-Li. "S-051." Epidemiology 23 (September 2012): 1. http://dx.doi.org/10.1097/01.ede.0000416905.44440.7e.

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3

Deardorff, Julianna, Stephanie Engel, John Paul Ekwaru, Gayle Windham, Susan Pinney, Carolyn Fang, Suzanne Miller, et al. "P-051." Epidemiology 23 (September 2012): 1. http://dx.doi.org/10.1097/01.ede.0000417062.60099.82.

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4

Rijckevorsel, Paul. "(051–052) Proposals on the retroactivity of Division III." TAXON 70, no. 2 (April 2021): 448. http://dx.doi.org/10.1002/tax.12463.

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5

Jhamb, U., and R. Prasad. "Abstract PD-051." Pediatric Critical Care Medicine 19 (June 2018): 46. http://dx.doi.org/10.1097/01.pcc.0000537453.90546.c3.

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6

Cho, H., H. J. Park, and S. Jeong. "Abstract P-051." Pediatric Critical Care Medicine 19 (June 2018): 64. http://dx.doi.org/10.1097/01.pcc.0000537508.86787.2c.

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7

Sturm, Katharina, and Friedrich R. Wollmershäuser. "Rezension von: Friedrich R. Wollmershäuser (Hg.), Auswanderungen aus dem Königreich Württemberg vor 1850. Auswanderer und Abwesende aus dem Königreich Württemberg und seinen Nachbarregionen, Bd. 1: 1785 – 1815, Bd. 2: 1816 – 1835." Zeitschrift für Württembergische Landesgeschichte 78 (January 21, 2022): 584–85. http://dx.doi.org/10.53458/zwlg.v78i.1562.

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Friedrich R. Wollmershäuser (Hg.), Auswanderungen aus dem Königreich Württemberg vor 1850. Auswanderer und Abwesende aus dem Königreich Württemberg und seinen Nachbarregionen, Bd. 1: 1785 – 1815, Bd. 2: 1816 – 1835, Ubstadt-Weiher: Verlag regionalkultur 2017. 864 S./724 S. deutsch/englisch, Bd. 1: ISBN 978-3-95505-051-1. € 89,90, Bd. 2: ISBN 978-3-95505-052-8. € 79,80

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8

Schweizer, Günther, and Friedrich R. Wollmershäuser. "Rezension von: Wollmershäuser, Friedrich R. (Hrsg.), Auswanderungen aus dem Königreich Württemberg vor 1850 ..." Schwäbische Heimat 70, no. 1 (January 4, 2022): 119–20. http://dx.doi.org/10.53458/sh.v70i1.1341.

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Анотація:

Friedrich R. Wollmershäuser (Hrsg.): Auswanderungen aus dem Königreich Württemberg vor 1850. Auswanderer und Abwesende aus dem Königreich Württemberg und seinen Nachbarregionen. Verlag regionalkultur Ubstadt-Weiher 2017. Zwei Bände, deutsch/englisch. Band 1: 1785-1815. 824 Seiten. Fest gebunden € 89,80. ISBN 978-3-95505-051-1. Band 2: 1816-1835. 724 Seiten. Fest gebunden € 79,80. ISBN 978-3-95505-052-8

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9

Clarke, Dominic. "051 Container systems: Bags." Cryobiology 67, no. 3 (December 2013): 412. http://dx.doi.org/10.1016/j.cryobiol.2013.09.057.

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10

Merlano, M. "SP-051: For the Motion." Radiotherapy and Oncology 106 (February 2013): S20—S21. http://dx.doi.org/10.1016/s0167-8140(15)34670-3.

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11

Bevan, R., C. Nickerson, J. Patnick, R. Loke, B. Saunders, J. Stebbing, R. Tighe, A. Veitch, J. Painter, and CJ Rees. "PWE-051 Bowelscope: Early Results From The Pilot Sites: Abstract PWE-051 Table 1." Gut 63, Suppl 1 (June 2014): A145.1—A145. http://dx.doi.org/10.1136/gutjnl-2014-307263.311.

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12

Peters, Stefanie, Michael Paolillo, Evanthia Mergia, Doris Koesling, Lea Kennel, Achim Schmidtko, Michael Russwurm, and Robert Feil. "cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators." International Journal of Molecular Sciences 19, no. 8 (August 7, 2018): 2313. http://dx.doi.org/10.3390/ijms19082313.

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Анотація:

Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms—NO-GC1 and NO-GC2—are known, represents a promising drug target to increase cGMP in the brain. Drug-like small molecules have been discovered that work synergistically with NO to stimulate NO-GC activity. However, the effects of NO-GC stimulators in the brain are not well understood. In the present study, we used Förster/fluorescence resonance energy transfer (FRET)-based real-time imaging of cGMP in acute brain slices and primary neurons of cGMP sensor mice to comparatively assess the activity of two structurally different NO-GC stimulators, IWP-051 and BAY 41-2272, in the cerebellum, striatum and hippocampus. BAY 41-2272 potentiated an elevation of cGMP induced by the NO donor DEA/NO in all tested brain regions. Interestingly, IWP-051 potentiated DEA/NO-induced cGMP increases in the cerebellum and striatum, but not in the hippocampal CA1 area or primary hippocampal neurons. The brain-region-selective activity of IWP-051 suggested that it might act in a NO-GC isoform-selective manner. Results of mRNA in situ hybridization indicated that the cerebellum and striatum express NO-GC1 and NO-GC2, while the hippocampal CA1 area expresses mainly NO-GC2. IWP-051-potentiated DEA/NO-induced cGMP signals in the striatum of NO-GC2 knockout mice but was ineffective in the striatum of NO-GC1 knockout mice. These results indicate that IWP-051 preferentially stimulates NO-GC1 signaling in brain slices. Interestingly, no evidence for an isoform-specific effect of IWP-051 was observed when the cGMP-forming activity of whole brain homogenates was measured. This apparent discrepancy suggests that the method and conditions of cGMP measurement can influence results with NO-GC stimulators. Nevertheless, it is clear that NO-GC stimulators enhance cGMP signaling in the brain and should be further developed for the treatment of neurological diseases.

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13

Eriksen, J. "SP-051: SBRT for oligometastatic disease." Radiotherapy and Oncology 114 (February 2015): 29. http://dx.doi.org/10.1016/s0167-8140(15)34811-8.

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14

Viviane, C. "051 Pain management in home care." BMJ Quality & Safety 19, Suppl 1 (April 1, 2010): A133—A134. http://dx.doi.org/10.1136/qshc.2010.041624.86.

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15

García-Muñoz, S., C. Sangrador-Pelluz, A. Albert-Mari, E. Soler-Company, R. Olivares-Pallerols, and M. Monzó-Rausell. "DGI-051 Oral Antineoplastic Treatment Adherence." European Journal of Hospital Pharmacy 20, Suppl 1 (March 2013): A114.1—A114. http://dx.doi.org/10.1136/ejhpharm-2013-000276.317.

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16

Marshall, M. B., and N. Haddad. "V-051 * OESOPHAGEAL DIVERTICULECTOMY AND MYOTOMY." Interactive CardioVascular and Thoracic Surgery 18, suppl 1 (June 1, 2014): S13. http://dx.doi.org/10.1093/icvts/ivu167.51.

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17

Klarskov, Peter, Jørgen Nordling, and John Bugge Nielsen. "Experience with Memokath 051 ureteral stent." Scandinavian Journal of Urology and Nephrology 39, no. 2 (April 2005): 169–72. http://dx.doi.org/10.1080/00365590510007720.

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18

RODRIGUES, MARIA JÚLIA DA SILVA, CARLOS ALBERTO DA SILVA LEDO, EDUARDO AUGUSTO GIRARDI, LUCAS ARAGÃO DA HORA ALMEIDA, and WALTER DOS SANTOS SOARES FILHO. "CARACTERIZAÇÃO DE FRUTOS E PROPAGAÇÃO DE PORTA-ENXERTOS HÍBRIDOS DE CITROS EM AMBIENTE PROTEGIDO." Revista Brasileira de Fruticultura 37, no. 2 (June 2015): 457–70. http://dx.doi.org/10.1590/0100-2945-068/14.

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A diversificação de uso de porta-enxertos de citros é importante no Brasil devido à presença de diversos estresses abióticos e bióticos, além da busca por atributos horticulturais desejáveis como nanismo, alta eficiência de produção e indução de boa qualidade aos frutos. Para a seleção de um genótipo com potencial de uso como porta-enxerto, porém, o desempenho na fase de propagação também é relevante. Assim, caracterizaram-se os frutos e avaliou-se a propagação em ambiente protegido de porta-enxertos híbridos de citros obtidos ou selecionados pelo Programa de Melhoramento Genético de Citros da Embrapa: citrandarins ‘Indio’, ‘Riverside’ e ‘San Diego’, híbridos HTR-051, TSKC x (LCR x TR)-040 e 059, LVK x LCR-010 e 038, TSKC x CTTR-002, TSKC x CTSW-041 e LCR x TR-001, além das variedades comerciais citrumelo ‘Swingle 4475’, trifoliata ‘Flying Dragon’, limoeiro ‘Cravo Santa Cruz’ e tangerineira ‘Sunki Tropical’. Foram avaliados variáveis biométricas, fisiológicas e coeficientes técnicos. O delineamento experimental foi em blocos ao acaso, com quatro repetições e 50 plantas na parcela ou 20 frutos por genótipo, conforme a avaliação. Citrumelo ‘Swingle’ e LVK x LCR-010 apresentaram alta produção de sementes por fruto, enquanto HTR-051 e LCR x TR-001 produziram as menores quantidades. A poliembrionia foi superior para TSKC x CTTR-002, TSKC x (LCR x TR)–040, LCR x TR-001, citrandarins ‘Indio’, ‘Riverside’ e ‘San Diego’ e tangerineira ‘Sunki Tropical’, tendo trifoliata ‘Flying Dragon’ e LVK x LCR-010 apenas 45% de poliembrionia média. A emergência de citrandarin ‘Riverside’ foi mais rápida e uniforme em relação aos demais genótipos. O crescimento vegetativo da parte aérea e do sistema radicular foi superior para citrandarin ‘Riverside’, TSKC x (LCR x TR)-059, tangerineira ‘Sunki Tropical’, citrumelo ‘Swingle’ e limoeiro ‘Cravo’ e seus híbridos. Todos os híbridos de citros avaliados apresentam potencial de uso como porta-enxertos.

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19

RODRIGUES, MARIA JÚLIA DA SILVA, ELDES REINAN MENDES DE OLIVEIRA, EDUARDO AUGUSTO GIRARDI, CARLOS ALBERTO DA SILVA LEDO, and WALTER DOS SANTOS SOARES FILHO. "PRODUÇÃO DE MUDAS DE CITROS COM DIFERENTES COMBINAÇÕES COPA E PORTA-ENXERTO EM VIVEIRO PROTEGIDO." Revista Brasileira de Fruticultura 38, no. 1 (February 2016): 187–201. http://dx.doi.org/10.1590/0100-2945-284/14.

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RESUMO O objetivo deste trabalho foi avaliar a produção de mudas de laranjeiras doces ‘Pera’ e ‘Westin’, tangerineira-tangor ‘Piemonte’ e limeira-ácida ‘Tahiti’ enxertadas em 14 porta-enxertos de citros em viveiro protegido. As mudas de laranjeiras-doces ‘Pera D-6’ e ‘Westin’, tangerineira-tangor ‘Piemonte’ e limeira-ácida ‘Tahiti CNPMF-02’ foram avaliadas em viveiro protegido após a enxertia, em 11 porta-enxertos híbridos: citrandarins ‘Indio’, ‘Riverside’ e ‘San Diego’, citrumelo ‘Swingle 4475’, HTR-051, TSKC x (LCR x TR)-040 e 059, LVK x LCR-010 e 038, TSKC x CTTR-002 e TSKC x CTSW-041, além de trifoliata ‘Flying Dragon’, limoeiro ‘Cravo Santa Cruz’ e tangerineira ‘Sunki Tropical’. Coletaram-se variáveis biométricas e fisiológicas, sendo o delineamento experimental em blocos ao acaso, em parcelas subdivididas, com 56 tratamentos, três repetições e dez plantas na parcela. Independentemente do porta-enxerto, a limeira-ácida ‘Tahiti CNPMF-02’ foi a copa mais vigorosa em viveiro, seguida da tangerineira-tangor ‘Piemonte’ e, por fim, pelas laranjeiras ‘Pera-D6’ e ‘Westin’. A tangerineira ‘Sunki Tropical’ induziu maior crescimento vegetativo e de sistema radicular em combinação com todas as copas estudadas. O trifoliata ‘Flying Dragon’ e o híbrido HTR-051 necessitam de maior período para a formação das mudas em função do menor vigor desses genótipos, em combinação com todas as variedades copas avaliadas. Não se observaram quaisquer sintomas de incompatibilidade entre as variedades no viveiro.

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20

Smith, Louise. "051 – Critical Care Staffing: Interviewing for Success." Journal of Pediatric Nursing 24, no. 2 (April 2009): e17. http://dx.doi.org/10.1016/j.pedn.2008.11.053.

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21

Fortes, C., R. R. Luiz, N. Fortes, R. Miranda, S. Xavier, M. Garcia, R. Fleury, et al. "051 INFECTIVE ENDOCARDITIS IN PATIENTS ON HEMODIALYSIS." International Journal of Antimicrobial Agents 33 (June 2009): S19. http://dx.doi.org/10.1016/s0924-8579(09)70070-6.

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22

Hirsch, E. "O.051 Iron transport in Parkinson's disease." Parkinsonism & Related Disorders 15 (December 2009): S14. http://dx.doi.org/10.1016/s1353-8020(09)70066-5.

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23

Fujiwara, S., and N. Takeo. "051 Carboxy-terminal structure of plectin-2." Journal of Dermatological Science 15, no. 2 (August 1997): 111. http://dx.doi.org/10.1016/s0923-1811(97)81755-0.

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24

Khettar, S., A. Clerc, JC Lega, and S. Durupt. "DI-051 Rifampicin-induced systemic lupus erythematosus." European Journal of Hospital Pharmacy 21, Suppl 1 (February 24, 2014): A90.3—A91. http://dx.doi.org/10.1136/ejhpharm-2013-000436.222.

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25

Choi, Seong H., Sung R. Kim, So-Hyun Kim, and Choong-Kun Ha. "P2-051: Cardiovascular autonomic dysfunction in dementia." Alzheimer's & Dementia 5, no. 4S_Part_9 (July 2009): P277. http://dx.doi.org/10.1016/j.jalz.2009.04.361.

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26

Weich, W. D., K. F. Kalscheur, and D. P. Casper. "051 Postpartum protein nutrition for dairy cows." Journal of Animal Science 94, suppl_2 (April 1, 2016): 23. http://dx.doi.org/10.2527/msasas2016-051.

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27

Duve, Thomas. "European Normativity – Global-Historical Perspectives." Rechtsgeschichte - Legal History 2014, no. 22 (2014): 051. http://dx.doi.org/10.12946/rg22/051-051.

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28

Armstrong, Colin A., James F. Sallis, John E. Alcaraz, Bohdan Kolody, Thomas L. McKenzie, and Melbourne F. Hovell. "Children's Television Viewing, Body Fat, and Physical Fitness." American Journal of Health Promotion 12, no. 6 (July 1998): 363–68. http://dx.doi.org/10.4278/0890-1171-12.6.363.

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Purpose. The study examines the relationship between children's television (TV) viewing and physical fitness. Design. Cross-sectional data from questionnaires and objective measures were analyzed. Setting. Data were collected during the fall of 1990 from public elementary school students in a suburban California city. Subjects. Approximately 98% of eligible students participated. Of these, 10% were dropped due to missing data, yielding a final sample of 284 girls and 304 boys. Measures. Children reported their amount of TV viewing on a typical summer day; parents reported their child's TV viewing on a typical weekday during the school year. Cardiovascular fitness was the 1-mile run/walk. Body fat was both the child's body mass index (BMI) and skinfolds. Additional measures included muscular strength/endurance and flexibility. Results. Mile run/walk times were associated with both parental (η2 = . 051 and . 031 for boys and girls, respectively) and child reports (η2 = . 020 and . 028) of the child's amount of TV viewing. Parental reports, but not child reports, of the child's TV viewing were related to BMI (η2 = .041 and .058) and skinfolds (η2 = .050 and .029). Neither measure of children's TV viewing was related to muscular strength/endurance or flexibility. Conclusions. Children's TV viewing seems to be weakly and inconsistently related to various components of physical fitness. However, given the tracking of cardiovascular disease risk factors from childhood into adulthood and the high proportion of children who watch television, these relationships are worthy of further study.

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29

Kemp, K., D. Byrne, R. Campbell, T. Law, W. McManus, and R. Willert. "PWE-051 Real life data of steroid free remission with adalimumab for ulcerative colitis: Abstract PWE-051 Table 1." Gut 64, Suppl 1 (June 2015): A234.1—A234. http://dx.doi.org/10.1136/gutjnl-2015-309861.500.

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30

Fayet, B., E. Racy, N. Rocher, and S. Dupont-Monod. "051 Dacryocystorhinostomie (DCR) endonasale : résultats à 5 ans." Journal Français d'Ophtalmologie 31 (April 2008): 30. http://dx.doi.org/10.1016/s0181-5512(08)70646-6.

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31

Kim, Young-Hoon, Deuk-Man Cho, Sung-Woo Park, Myung-Jin Joo, Bong-Ju Lee, Tae-Min Ha, Bo-Geum Kong, and Jung-Goo Rhee. "P4-051 Alzheimer's disease and 5-HTTLPR polymorphism." Neurobiology of Aging 25 (July 2004): S487. http://dx.doi.org/10.1016/s0197-4580(04)81609-9.

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32

Babb, C., P. Pacik, L. Holmes, and C. Goekeler. "051 Psychosocial Predictors of Pain in Primary Vaginismus." Journal of Sexual Medicine 15, no. 6 (June 2018): S112. http://dx.doi.org/10.1016/j.jsxm.2018.03.047.

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33

Etkina, E., E. Pokshubina, I. Etkina, and L. Lepilina. "051. Estimation of Exotoxicant Influence on Children's Health." Prehospital and Disaster Medicine 10, S2 (September 1995): S26. http://dx.doi.org/10.1017/s1049023x00500612.

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34

Quiroga, I., D. Sweeney, P. M. Sutton, S. D. J. Chapple, J. P. Souto-Grando, M. C. N. M. Barnardo, and S. V. Fuggle. "Identification of a novel MICA allele: MICA*051." Tissue Antigens 63, no. 5 (May 2004): 466–69. http://dx.doi.org/10.1111/j.0001-2815.2004.00195.x.

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35

Price, J. "IS-051 Neural Embryonic Stem/isps Cell Therapy." Archives of Disease in Childhood 99, Suppl 2 (October 2014): A16.4—A17. http://dx.doi.org/10.1136/archdischild-2014-307384.51.

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36

Wang, J. H‐C, and G. Q. Wang. "051 Superoxide Regulates ??SMA via p?38 MAPK." Wound Repair and Regeneration 12, no. 2 (March 2004): A15. http://dx.doi.org/10.1111/j.1067-1927.2004.0abstractax.x.

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37

Chauhan, A., Z. Mynt, S. Arnold, B. Grant, and L. Anthony. "P2.07-051 Immune Checkpoint Associated Cardiotoxicity: An Update." Journal of Thoracic Oncology 12, no. 11 (November 2017): S2148—S2149. http://dx.doi.org/10.1016/j.jtho.2017.09.1307.

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38

Subramaniam, S., G. Goodchild, and K. Besherdas. "PTU-051 Odynophagia – A Symptom Worth Asking About?" Gut 63, Suppl 1 (June 2014): A60.2—A61. http://dx.doi.org/10.1136/gutjnl-2014-307263.125.

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39

Cipin, R., J. Kadlec, B. Klima, and P. Hutak. "Battery System for the Airplane VUT 051 RAY." ECS Transactions 48, no. 1 (January 21, 2014): 217–22. http://dx.doi.org/10.1149/04801.0217ecst.

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40

Dimmitt, S., and H. Stampfer. "051 Essential Antihypertensive Drug Dose Guided by ED50." Heart, Lung and Circulation 29 (2020): S60—S61. http://dx.doi.org/10.1016/j.hlc.2020.09.058.

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41

Alaqeel, S., and N. Abanmy. "GRP-051 Dispensing Practise in Saudi Community Pharmacy." European Journal of Hospital Pharmacy 20, Suppl 1 (March 2013): A19.1—A19. http://dx.doi.org/10.1136/ejhpharm-2013-000276.051.

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42

Pazdera, Ivo, Bohumil Klima, Dalibor Cervinka, Antonin Pistek, and Jiri Hlinka. "Battery System of Electric Airplane VUT 051 RAY." ECS Transactions 40, no. 1 (December 16, 2019): 267–73. http://dx.doi.org/10.1149/1.4729113.

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43

Harrington, C., L. Smith, J. Munro, S. Laird, A. Cahill, D. Gaya, A. Morris, and J. Winter. "PTU-051 Iatrogenic Hypokalaemia in Acute Severe Colitis." Gut 65, Suppl 1 (June 2016): A77.2—A77. http://dx.doi.org/10.1136/gutjnl-2016-312388.138.

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Gashirai, Mbizvo, Derry Chris, and Davenport Richard. "THUR 051 Ictal asystole: return to the history." Journal of Neurology, Neurosurgery & Psychiatry 89, no. 10 (September 13, 2018): A6.1—A6. http://dx.doi.org/10.1136/jnnp-2018-abn.21.

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In these two adult cases of transient loss of consciousness (TLoC), careful history-taking revealed a stereotyped prodrome of déjà vu suggestive of focal seizures. One patient had an implantable cardiac monitor fitted, the other a 48 hour Holter monitor. Each patient subsequently had a typical event of déjà vu followed by TLoC with rapid recovery and for both, the monitor showed cardiac asystole corresponding with this event. A permanent pacemaker (PPM) was inserted in both patients. This abolished TLoC. In its absence, déjà vu became more frequent, intense, and prolonged for one patient, resolving with levetiracetam. The other patient had a post-PPM episode of déjà vu followed by a generalised tonic-clonic seizure. It transpired that their lamotrigine had been withdrawn following PPM insertion. Seizure-freedom was achieved by restarting lamotrigine.Ictal asystole, a rare complication of focal epilepsy, has a mean ventricular standstill duration of 20 s. This can be benign or progress to post-ictal asystole −fatal in 54% of cases. Careful attention should be paid to prodromal symptoms suggestive of focal seizures (including ‘auras’) in patients presenting with what might otherwise sound like syncope. These patients may have epilepsy presenting with ictal asystole and require antiepileptic drugs alongside their cardiac investigations/interventions.

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Dawodu, Oseluese, and Alex V. Levin. "051: Spontaneous disconnection of tube extenders in situ." Journal of American Association for Pediatric Ophthalmology and Strabismus 13, no. 1 (February 2009): e13. http://dx.doi.org/10.1016/j.jaapos.2008.12.022.

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Khmelkova, N. "051-PA10 Tuberculosis diagnosis in General City Hospital." Tubercle and Lung Disease 76 (October 1995): 27. http://dx.doi.org/10.1016/0962-8479(95)90117-5.

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47

Shen, Yuqiao, Galila Kitzes, Julie A. Nye, Ali Fattaey, and Terry Hermiston. "Analyses of Single-Amino-Acid Substitution Mutants of Adenovirus Type 5 E1B-55K Protein." Journal of Virology 75, no. 9 (May 1, 2001): 4297–307. http://dx.doi.org/10.1128/jvi.75.9.4297-4307.2001.

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ABSTRACT The E1B-55K protein plays an important role during human adenovirus type 5 productive infection. In the early phase of the viral infection, E1B-55K binds to and inactivates the tumor suppressor protein p53, allowing efficient replication of the virus. During the late phase of infection, E1B-55K is required for efficient nucleocytoplasmic transport and translation of late viral mRNAs, as well as for host cell shutoff. In an effort to separate the p53 binding and inactivation function and the late functions of the E1B-55K protein, we have generated 26 single-amino-acid mutations in the E1B-55K protein. These mutants were characterized for their ability to modulate the p53 level, interact with the E4orf6 protein, mediate viral late-gene expression, and support virus replication in human cancer cells. Of the 26 mutants, 24 can mediate p53 degradation as efficiently as the wild-type protein. Two mutants, R240A (ONYX-051) and H260A (ONYX-053), failed to degrade p53 in the infected cells. In vitro binding assays indicated that R240A and H260A bound p53 poorly compared to the wild-type protein. When interaction with another viral protein, E4orf6, was examined, H260A significantly lost its ability to bind E4orf6, while R240A was fully functional in this interaction. Another mutant, T255A, lost the ability to bind E4orf6, but unexpectedly, viral late-gene expression was not affected. This raised the possibility that the interaction between E1B-55K and E4orf6 was not required for efficient viral mRNA transport. Both R240A and H260A have retained, at least partially, the late functions of wild-type E1B-55K, as determined by the expression of viral late proteins, host cell shutoff, and lack of a cold-sensitive phenotype. Virus expressing R240A (ONYX-051) replicated very efficiently in human cancer cells, while virus expressing H260A (ONYX-053) was attenuated compared to wild-type virus dl309 but was more active than ONYX-015. The ability to separate the p53-inactivation activity and the late functions of E1B-55K raises the possibility of generating adenovirus variants that retain the tumor selectivity of ONYX-015 but can replicate more efficiently than ONYX-015 in a broad spectrum of cell types.

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Pedrol Aguilà, Marina. "Santa, Àngels, (2018) Ensoñaciones literarias. Lleida, Ediciones de la Universitat de Lleida / Pagès Editors, col. El Fil d’Ariadna nº65, 385 pp., ISBN: 978-84-1303-051-7." Thélème. Revista Complutense de Estudios Franceses 35, no. 2 (October 22, 2020): 303–6. http://dx.doi.org/10.5209/thel.71138.

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Ferreira Rubio, Delia M. "The Constitution – Latin America 2010." Rechtsgeschichte - Legal History 2010, no. 16 (2010): 050–51. http://dx.doi.org/10.12946/rg16/050-051.

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Raghavan, Malathi, Karen Brandt, and David Granstrom. "Letter to the Editor." Journal of Veterinary Medical Education 41, no. 3 (September 2014): 205–7. http://dx.doi.org/10.3138/jvme.0514-051.

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