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Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 29 січня 2023

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1

Kovalson, V. M., A. O. Golovatyuk, and M. G. Poluektov. "Biologically active molecules and sleep." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 122, no. 5 (2022): 6. http://dx.doi.org/10.17116/jnevro20221220526.

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2

Hamilton, A. D., N. Pant, and A. Muehldorf. "Artificial receptors for biologically active molecules." Pure and Applied Chemistry 60, no. 4 (January 1, 1988): 533–38. http://dx.doi.org/10.1351/pac198860040533.

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3

Karolak-Wojciechowska, J., and A. Fruzinski. "Spacer conformation in biologically active molecules." Pure and Applied Chemistry 76, no. 5 (January 1, 2004): 959–64. http://dx.doi.org/10.1351/pac200476050959.

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Анотація:

Based on our contemporary studies on the structures of biologically active molecules, we focus our attention on the aliphatic chain and its conformation. That flexible spacer definitely influenced the balanced position of all pharmacophoric points in molecules of biological ligands. The one atomic linker and two or three atomic spacers with one heteroatom X =O, S, CH2, NH have been taken into account. The conformational preferences clearly depend on the heteroatom X. In the discussion, we utilize our own X-ray data, computation chemistry methods, population analysis, and statistical data from the Cambridge Structural Database (CSD).

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4

Weissig, Volkmar. "Mitochondrial Delivery of Biologically Active Molecules." Pharmaceutical Research 28, no. 11 (September 21, 2011): 2633–38. http://dx.doi.org/10.1007/s11095-011-0588-1.

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5

Kanai, Motomu, and Masakatsu Shibasaki. "Catalytic Asymmetric Synthesis of Biologically Active Molecules." Journal of Synthetic Organic Chemistry, Japan 65, no. 5 (2007): 439–49. http://dx.doi.org/10.5059/yukigoseikyokaishi.65.439.

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6

Mayer, Günter, and Alexander Heckel. "Biologically Active Molecules with a “Light Switch”." Angewandte Chemie International Edition 45, no. 30 (July 24, 2006): 4900–4921. http://dx.doi.org/10.1002/anie.200600387.

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7

Insuasty, Daniel, Juan Castillo, Diana Becerra, Hugo Rojas, and Rodrigo Abonia. "Synthesis of Biologically Active Molecules through Multicomponent Reactions." Molecules 25, no. 3 (January 24, 2020): 505. http://dx.doi.org/10.3390/molecules25030505.

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Анотація:

Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at least tested for any biological property. Given the diversity of synthetic approaches utilized in MCRs, the highly diverse nature of the biological activities evaluated for the synthesized compounds, and considering their huge structural variability, much of the reported data are organized into concise schemes and tables to facilitate comparison, and to underscore the key points of this review.

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8

Banik, Bimal Krishna. "Microwave-Induced Organic Reactions Toward Biologically Active Molecules." Current Medicinal Chemistry 26, no. 24 (October 11, 2019): 4492–94. http://dx.doi.org/10.2174/092986732624190927114808.

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9

Piletsky, S. A., E. V. Piletska, T. A. Sergeyeva, I. A. Nicholls, D. Weston, and A. P. F. Turner. "Synthesis of biologically active molecules by imprinting polymerisation." Biopolymers and Cell 22, no. 1 (January 20, 2006): 63–67. http://dx.doi.org/10.7124/bc.00071c.

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10

Setchenkov, M. S., S. I. Usmanova, Yu G. Afanas’eva, and R. S. Nasibullin. "Complexing of some biologically active molecules with phosphatidylcholine." Russian Physics Journal 52, no. 4 (April 2009): 417–20. http://dx.doi.org/10.1007/s11182-009-9235-2.

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11

Klasinc, L., and S. P. McGlynn. "Photoelectron spectroscopy of biologically active molecules. 21. Thiooxamides." International Journal of Quantum Chemistry 38, S24 (March 17, 1990): 813–20. http://dx.doi.org/10.1002/qua.560382479.

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12

Yevdokimov, Y. M. "Double-stranded DNA liquid-crystalline dispersions as biosensing units." Biochemical Society Transactions 28, no. 2 (February 1, 2000): 77–81. http://dx.doi.org/10.1042/bst0280077.

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Анотація:

Three different approaches to constructing bio-sensing units based on double-stranded (ds) DNA molecules, capable of detecting various biologically active compounds, are considered. The first approach is based on the abnormal optical activity of the liquid-crystalline dispersion formed from ds DNA molecules, modified by relevant physical factors or treated with biologically active compounds. The second one is based on the abnormal optical activity of the liquid-crystalline dispersions formed first from the ds DNA and then treated with coloured biologically active compounds. The third one is based on the abnormal optical activity, specific to particles of the liquid-crystalline dispersions, where the neighbouring DNA molecules are crosslinked by artifical polymeric bridges. These approaches permit the detection of biologically relevant compounds of various origins.

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13

Kuzminykh, Tatyana U., Vera Yu Borisova, Igor P. Nikolayenkov, Georgy R. Kozonov, and Gulrukhsor Kh Tolibova. "Role of biologically active molecules in uterine contractile activity." Journal of obstetrics and women's diseases 68, no. 1 (March 20, 2019): 21–27. http://dx.doi.org/10.17816/jowd68121-27.

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Анотація:

Hypothesis/aims of study. Myometrial relaxation and contraction require synchronous cellular interactions. At present, it has been established that the coordination of myometrial contractile activity is carried out by a conduction system constructed from gap junctions with intercellular channels. There are no clinical data on inhibiting (nitric oxide synthase) and activating (connexin-43) factors of uterine contractile activity in the myometrium during pregnancy and parturition in the published literature. This study was undertaken to measure the expression levels of nitric oxide synthase, adhesion molecules CD51, CD61, and connexin-43 in the myometrium during pregnancy and parturition; and to assess the role of inhibitory and activating factors in the development of uterine contractile activity. Study design, materials and methods. An immunohistochemical study of myometrial biopsy specimens obtained from the lower uterus segment during cesarean section was performed in eight women with a full-term physiological pregnancy, in another eight individuals in the active phase of uncomplicated parturition, and in eight patients with uterine inertia. Integrins (CD51 and CD61 proteins) were used as markers of cell adhesion. Localization and the number of intercellular contacts were assessed by measuring the expression level of connexin-43, with the intensity of oxidative processes assessed by nitric oxide synthase activity. Results. In the myometrium, in the active phase of physiological parturition, a three-fold increase in the expression of activating (CD51, CD61, and connexin-43) factors of uterine contractile activity and a five-fold decrease in that of inhibitory (nitric oxide synthase) ones occur compared to those in full-term physiological pregnancy. Conclusion. In the pathogenesis of uterine inertia and resistance to labor induction, an important role is played by the decreased expression of adhesion molecules (CD51, CD61) and connexin-43 and the increased expression of nitric oxide synthase in the myometrium.

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14

URYU, Toshiyuki. "Discovery and Chemical Glyco-molecules Synthesis of Biologically Active." Kobunshi 45, no. 8 (1996): 533. http://dx.doi.org/10.1295/kobunshi.45.533.

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15

Raina, Deepak Bushan, Yang Liu, Hanna Isaksson, Magnus Tägil, and Lars Lidgren. "Synthetic hydroxyapatite: a recruiting platform for biologically active molecules." Acta Orthopaedica 91, no. 2 (November 4, 2019): 126–32. http://dx.doi.org/10.1080/17453674.2019.1686865.

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16

Brown, Simon, and Paul Alewood. "Venom as a source of useful biologically active molecules." Emergency Medicine 13, no. 3 (September 2001): 389–90. http://dx.doi.org/10.1046/j.1035-6851.2001.00248.x.

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17

Gupta, Sanjeev K., Haiying He, Chunhui Liu, Ranu Dutta, and Ravindra Pandey. "Interaction of metallic clusters with biologically active curcumin molecules." Chemical Physics Letters 636 (September 2015): 163–66. http://dx.doi.org/10.1016/j.cplett.2015.07.040.

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18

Zalipsky, Samuel. "Chemistry of polyethylene glycol conjugates with biologically active molecules." Advanced Drug Delivery Reviews 16, no. 2-3 (September 1995): 157–82. http://dx.doi.org/10.1016/0169-409x(95)00023-z.

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19

Banik, Bimal Krishna. "Indium Metal-Induced Reactions: Synthesis of Biologically Active Molecules." Asian Journal of Chemistry 30, no. 1 (2017): 1–4. http://dx.doi.org/10.14233/ajchem.2018.20935.

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20

Desai, Urvee A., Judit Pallos, Aye Aye K. Ma, Brent R. Stockwell, Leslie Michels Thompson, J. Lawrence Marsh, and Marc I. Diamond. "Biologically active molecules that reduce polyglutamine aggregation and toxicity." Human Molecular Genetics 15, no. 13 (May 23, 2006): 2114–24. http://dx.doi.org/10.1093/hmg/ddl135.

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21

Bailey, Paul, and Jacqueline Wilce. "Venom as a source of useful biologically active molecules." Emergency Medicine 13, no. 1 (March 2001): 28–36. http://dx.doi.org/10.1046/j.1442-2026.2001.00174.x.

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22

Liyarita, Bella Rosa, Adriano Ambrosi, and Martin Pumera. "3D-printed Electrodes for Sensing of Biologically Active Molecules." Electroanalysis 30, no. 7 (January 29, 2018): 1319–26. http://dx.doi.org/10.1002/elan.201700828.

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23

Beger, Richard D. "Computational modeling of biologically active molecules using NMR spectra." Drug Discovery Today 11, no. 9-10 (May 2006): 429–35. http://dx.doi.org/10.1016/j.drudis.2006.03.014.

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24

Klasinc, L., S. P. Mcglynn, L. J. Paša-Tolić, and B. Kovač. "Photoelectron spectroscopy of biologically active molecules. 17. unsaturated steroids." International Journal of Quantum Chemistry 36, S16 (June 19, 2009): 331–41. http://dx.doi.org/10.1002/qua.560360727.

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25

Davies, R. H., D. A. Smith, D. J. McNeillie, and T. R. Morris. "Identification of biologically active conformations in flexible drug molecules." International Journal of Quantum Chemistry 16, S6 (June 19, 2009): 203–21. http://dx.doi.org/10.1002/qua.560160714.

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26

Klasinc, L., I. Novak, A. Sablji?, and S. P. McGlynn. "Photoelectron spectroscopy of biologically active molecules. XVI. Benzophenone derivatives." International Journal of Quantum Chemistry 34, S15 (March 12, 1988): 259–66. http://dx.doi.org/10.1002/qua.560340723.

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27

Pakeeraiah, K., Sujit Kumar Mohanty, K. Eswar, and K. Raju. "Azo benzimidazole - A biologically active scaffold." International Journal of PharmTech Research 13, no. 3 (2020): 159–71. http://dx.doi.org/10.20902/ijptr.2019.130305.

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Анотація:

Azo compounds are a very unique class of chemical compounds, drawing considerations in scientific research. Azo compounds are studied as class of organic colorants which have at least a conjugated chromophore azo (-N=N-) group in fusion with one or more aromatic or heterocyclic ring system. Benzimidazole derivatives are privileged intermediates for the development of molecules of pharmaceutical or biological interest. Benzimidazole derivatives have gathered wide applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few. Although many azo derivatives of benzimidazole nucleus has been reported in literature but only few of them have been evaluated for their biological potencies. This review focuses primarily on those derivatives which are evaluated as anticancer, antibacterial, antifungal, antitubercular, and other medicinal agents. This review may be helpful for the investigators on the basis of substitution pattern on the nucleus with an objective to assist medicinal chemists for developing an SAR on azo benzimidazoles or similar compounds.

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28

Freeman, Amihay, Yael Dror, Carmit Ophir Porat, Noa Hadar, and Yossi Shacham Diamand. "Silver-Coated Biologically Active Protein Hybrids: Antimicrobial Applications." Applied Mechanics and Materials 749 (April 2015): 453–56. http://dx.doi.org/10.4028/www.scientific.net/amm.749.453.

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Novel hybrids, comprised of a biologically active protein molecule core, coated with a thin outer layer of porous metallic silver, were developed in our lab. By the conjugation of silver reducing polymer to the surface of soluble, molecular, biologically active protein molecules and subsequent addition of silver salt, electroless silver deposition, culminating in thin porous metallic coating, was directed to the surface of the protein molecules. The silver-protein hybrids thus obtained, presenting novel nanoparticles several nanometers in size, retained their solubility and biological activity.The silver coating combined with the retained biological activity of its protein core, paved the way to a series of biomedical applications of these hybrids including "wiring" of the active site of oxido-reductase enzyme to electrodes, imaging of the presence of targeted ligands displayed on cancer cell surface and antimicrobial enzymatically attenuated release of silver ions.In this presentation we shall overview the technology of protein-silver hybrid's fabrication and analytical applications of silver-glucose oxidase and silver-Avidin hybrids, followed by feasibility demonstration of using silver-glucose oxidase hybrid as novel antibacterial and antifungal agent.

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29

Takayama, Kentaro, and Yoshio Hayashi. "Medicinal Chemistry of Mid-sized Molecules on Biologically Active Peptides." Journal of Synthetic Organic Chemistry, Japan 73, no. 7 (2015): 737–48. http://dx.doi.org/10.5059/yukigoseikyokaishi.73.737.

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30

Rizzo, Carmen, and Angelina Lo Giudice. "Marine Invertebrates: Underexplored Sources of Bacteria Producing Biologically Active Molecules." Diversity 10, no. 3 (June 27, 2018): 52. http://dx.doi.org/10.3390/d10030052.

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31

B. Azeredo, Juliano, Ricardo S. Schwab, and Antonio L. Braga. "Synthesis of Biologically Active Selenium-Containing Molecules From Greener Perspectives." Current Green Chemistry 3, no. 1 (March 3, 2016): 51–67. http://dx.doi.org/10.2174/2213346103666160127003506.

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32

Diopan, Vaclav, Vojtech Adam, Ladislav Havel, and Rene Kizek. "Phytohormones as Important Biologically Active Molecules – Their Simple Simultaneous Detection." Molecules 14, no. 5 (May 15, 2009): 1825–39. http://dx.doi.org/10.3390/molecules14051825.

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33

Karatas, Aysegul, and Aslıhan Algan. "Template Synthesis of Tubular Nanostructures for Loading Biologically Active Molecules." Current Topics in Medicinal Chemistry 17, no. 13 (April 4, 2017): 1555–63. http://dx.doi.org/10.2174/1568026616666161222110859.

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34

Cañeque, Tatiana, Sebastian Müller, and Raphaël Rodriguez. "Visualizing biologically active small molecules in cells using click chemistry." Nature Reviews Chemistry 2, no. 9 (August 16, 2018): 202–15. http://dx.doi.org/10.1038/s41570-018-0030-x.

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35

LIM, C. K. "Ion-Exchange Sorption and Preparative Chromatography of Biologically Active Molecules." Biochemical Society Transactions 15, no. 3 (June 1, 1987): 569–70. http://dx.doi.org/10.1042/bst0150569a.

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36

Ashrafuzzaman, Md, M. A. Lampson, D. V. Greathouse, R. E. Koeppe, and O. S. Andersen. "Manipulating lipid bilayer material properties using biologically active amphipathic molecules." Journal of Physics: Condensed Matter 18, no. 28 (June 28, 2006): S1235—S1255. http://dx.doi.org/10.1088/0953-8984/18/28/s08.

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37

DING, X., G. YANG, X. WANG, Z. WANG, and H. LIN. "Interaction of Biologically Active Molecules with Sulfur-modified Gold Surface." Chemical Research in Chinese Universities 23, no. 3 (May 2007): 339–42. http://dx.doi.org/10.1016/s1005-9040(07)60072-5.

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38

Rana, Aniruddhasinh M., Kishor R. Desai, and Smita Jauhari. "Rhodanine-based biologically active molecules: synthesis, characterization, and biological evaluation." Research on Chemical Intermediates 40, no. 2 (January 22, 2013): 761–77. http://dx.doi.org/10.1007/s11164-012-1001-3.

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39

Murray, Patrick M., Siobhan Moane, Catherine Collins, Tanya Beletskaya, Olivier P. Thomas, Alysson W. F. Duarte, Fernando S. Nobre, et al. "Sustainable production of biologically active molecules of marine based origin." New Biotechnology 30, no. 6 (September 2013): 839–50. http://dx.doi.org/10.1016/j.nbt.2013.03.006.

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40

Dube, Dipak K., Margaret E. Black, Khan M. Munir, and Lawrence A. Loeb. "Selection of new biologically active molecules from random nucleotide sequences." Gene 137, no. 1 (December 1993): 41–47. http://dx.doi.org/10.1016/0378-1119(93)90249-3.

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41

Abet, Valentina, Angelica Mariani, Fiona R. Truscott, Sébastien Britton, and Raphaël Rodriguez. "Biased and unbiased strategies to identify biologically active small molecules." Bioorganic & Medicinal Chemistry 22, no. 16 (August 2014): 4474–89. http://dx.doi.org/10.1016/j.bmc.2014.04.019.

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42

Suga, Takayuki, Masahiko Hirano, Masayo Takayanagi, Hiroyuki Koshimoto, and Akihiko Watanabe. "Restricted Photorelease of Biologically Active Molecules near the Plasma Membrane." Biochemical and Biophysical Research Communications 253, no. 2 (December 1998): 423–30. http://dx.doi.org/10.1006/bbrc.1998.9153.

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43

Plé, N., A. Turck, F. Bardin, and G. Queguiner. "Metallation of diazines.V. Synthesis of analogues of biologically active molecules." Journal of Heterocyclic Chemistry 29, no. 2 (March 1992): 467–70. http://dx.doi.org/10.1002/jhet.5570290229.

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44

Klasinc, L., I. Novak, A. SabljiĆ, S. P. Mcglynn, and L. Klasinc. "Photoelectron spectroscopy of biologically active molecules 12 benzene-containing amides." International Journal of Quantum Chemistry 30, S13 (June 19, 2009): 251–60. http://dx.doi.org/10.1002/qua.560300824.

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45

Kalchenko, Olga, Sergiy Cherenok, Sergiy Suikov, and Vitaly Kalchenko Vitaly Kalchenko. "Study of Calixarene Complexation with Biologically Active." French-Ukrainian Journal of Chemistry 5, no. 2 (2017): 49–55. http://dx.doi.org/10.17721/fujcv5i2p49-55.

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Анотація:

Host-Guest complexation of octakis(diphenoxyphosphoryloxy)tetramethylcalix[4]resorcinarene CRA and 5,17-bis-(N-tolyliminomethyl)-25,27-dipropoxycalix[4]arene CA with bio relevant aromatic, pyridine and diterpenoid carboxylic acids in water-organic solution had been studied by the RP HPLC and molecular modelling methods. The stability constants KA (387-1914 М-1) of the supramolecular complexes had been determined. It was shown the Host-Guest interactions are depended on structure of the Host molecules and log P values of the Guests. The complexation is determined by the hydrogen bonds of the COOH group of the carboxylic acids with P=O oxygen atom of diphenoxyphosphoryl group of the calixresorcinarene CRA, and oxygen or nitrogen atoms located on the lower or the upper rim of the calixarene CA.

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46

Воронин, Д. П., and D. P. Voronin. "Model of Complexation between C60 Fullerenes and Biologically Active Compounds." Mathematical Biology and Bioinformatics 12, no. 2 (December 6, 2017): 457–65. http://dx.doi.org/10.17537/2017.12.457.

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Анотація:

Various model approaches for describing the equilibrium complexation of aromatic biologically active compounds with fullerene C60 molecules are proposed. Equilibrium constants of complexation for structurally different biologically active compounds in the aquatic environment were obtained based on these approaches. Models of continuous and discrete aggregation of C60 molecules are proposed, taking into account the polydisperse nature of fullerene solutions. The model of continuous aggregation considers the sequential growth of aggregates upon addition of C60 fullerene monomers to the already existing aggregates, with the equilibrium self-association constant of fullerene KF being the same for all stages of aggregation. The discrete model takes into account the presence of separate stable aggregates and fractal type of the higher aggregates formation from C60 fullerene aggregates. It is achieved by using the simplest two-level hierarchy of clusters distribution in the fractal series 1-4-7-13, known from the literature data. The model of continuous aggregation represents the classical approach used throughout to describe the aggregation of small molecules, while the discrete aggregation model can only be applied to fullerenes. The results obtained in this study lead to the conclusion that fullerene C60 can form stable complexes with aromatic antitumor drugs, which open the possibility of using these substrates in the future in cancer therapy.

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47

Gelat, Fabien, Claire Lacomme, Olivier Berger, Laurent Gavara, and J. L. Montchamp. "Synthesis of (phosphonomethyl)phosphinate pyrophosphate analogues via the phospha-Claisen condensation." Organic & Biomolecular Chemistry 13, no. 3 (2015): 825–33. http://dx.doi.org/10.1039/c4ob02007c.

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48

Zatloukalová, Martina. "3D Lipidic Matrix for Incorporation and Stabilization of Biologically Active Molecules." Chemické listy 116, no. 3 (March 15, 2022): 172–79. http://dx.doi.org/10.54779/chl20220172.

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Анотація:

In aqueous media, biologically active substances are usually unstable, poorly soluble compounds with low bioavailability. Incorporation of these compounds into the structure of lipid-based lyotropic liquid crystalline phase or nanoparticles can increase their solubility and subsequent bioavailability. The aim of this review is to clarify the principle of self-assembly of lipidic amphiphilic molecules in the aqueous environment, to present lipid bicontinuous cubic and hexagonal phases and their current biological application.

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49

Novotny, L., and P. Rauko. "Cytarabine conjugates with biologically active molecules and their potential anticancer activity." Neoplasma 56, no. 3 (2009): 177–86. http://dx.doi.org/10.4149/neo_2009_03_177.

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Yevdokimov, Yu, V. Salyanov, and M. Palumbo. "Liquid Crystalline State of DNA Molecules Complexed with Biologically Active Compounds." Molecular Crystals and Liquid Crystals 131, no. 3-4 (January 1985): 285–97. http://dx.doi.org/10.1080/00268948508085050.

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