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Rahajeng Irna Sari and Siti Istikhoroh. "PENGARUH HARGA, KUALITAS PRODUK, KUALITAS LAYANAN & LOKASI TERHADAP KEPUTUSAN PEMBELIAN LAPIS KUKUS PAHLAWAN." Journal of Sustainability Bussiness Research (JSBR) 1, no. 1 (December 30, 2020): 540–48. http://dx.doi.org/10.36456/jsbr.v1i1.3052.
Повний текст джерелаАнотація:
Dijelaskan riset menganalisa harga, kualitas produk, kualitas layanan serta lokasi terhadap keputusan pembelian lapis kukus pahlawan. Riset ini memakai pendekatakan kuantitatif deskriptif, telah diperoleh hasil thitung 2,564 serta Sig. sebesar ,012 sehingga ,012 < ,05. kualitas produk 2,055 sig. ,043<,05. kualitas layanan 2,216 serta Sig. ,036. lokasi 2,231 serta Sig. ,028. nilai f-hitung serta diketahui F hitung 5,972 serta sig. ,000 < 0,05. Disimpulkan pengujian secara terpisah serta bersamaan terbukti adanya pengaruh variabel bebas terhadap variabel terikat.
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Dykstra, Rachel, Panagiotis Koutakis, and Nicholas Hanson. "Relationship Between Physical Fitness Variables and Reaction Time in eSports Gamers." International Journal of eSports Research 1, no. 1 (January 2021): 1–14. http://dx.doi.org/10.4018/ijer.288540.
Повний текст джерелаАнотація:
eSports gaming requires quick and accurate reactions in response to complex visual stimuli for optimal performance. The purpose of this study was to examine the relationship between components of physical fitness and reaction time (RT) in eSports gamers. 27 eSports gamers participated. Visit 1 included physical fitness assessments. Visit 2 included a familiarization with the Stroop Task. During Visit 3, subjects completed the Stroop Task again; data from this visit was used for analyses. For congruent, incongruent and control trials, an inverse efficiency score (IES) was calculated. Pearson correlations were used to determine the relationship between components of physical fitness and mean RT. There was a significant correlation between mean RT and cardiorespiratory fitness (r=-.338, p=.043). IES was significantly related to cardiorespiratory fitness in incongruent (r=-.373, p=.028) and control (r=-.333, p=.045) trials. Results suggest that increased cardiorespiratory fitness can improve reaction time and also induce greater efficiency.
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Tong, J., MS Gordon, EF Srour, RJ Cooper, A. Orazi, I. McNiece, and R. Hoffman. "In vivo administration of recombinant methionyl human stem cell factor expands the number of human marrow hematopoietic stem cells." Blood 82, no. 3 (August 1, 1993): 784–91. http://dx.doi.org/10.1182/blood.v82.3.784.784.
Повний текст джерелаАнотація:
Abstract A growing number of in vitro studies suggest that recombinant human stem cell factor (SCF) is capable of augmenting the proliferative capacity of human hematopoietic progenitor cells (HPC) and stem cells (HSC). We further evaluated this biologic effect by analyzing the response of bone marrow (BM) HPCs and HSCs to the administration of SCF in eight patients with locally advanced or metastatic breast cancer who were enrolled in an ongoing phase I study. SCF was administered for 14 days by daily subcutaneous injection at dosages of 10, 25, or 50 micrograms/kg/d. BM CD34+ HLA-DR+ and CD34+ HLA-DR- CD15- cells, previously shown by our laboratory to be enriched for various classes of differentiated and primitive HPCs, respectively, were quantitated in BM samples on day 0 (pretreatment) and day 15 (posttreatment). These CD34+ HLA-DR+ and CD34+ HLA-DR- CD15- cells were then isolated by cell- sorting and assayed for several classes of HPCs, including the high-- proliferative potential colony-forming cell (HPP-CFC), the burst- forming unit--megakaryocyte (BFU-MK), and the long-term BM culture-- initiating cell (LTBMC-IC). SCF administration resulted in a 3.3-fold (range, 1.4- to 18.8-fold; P = .018) increase in the absolute numbers of CD34+ cells, a 3.7-fold (range, 1.2- to 8.2-fold; P = .028) increase in the absolute numbers of CD34+ HLA-DR+ cells, and a 2.4-fold (range, 1.1- to 29.3-fold; P = .010) increase in the absolute numbers of CD34+ HLA-DR- CD15- cells. Following the infusion of SCF, a statistically significant increase in the absolute numbers of HPP-CFC (P = .018), BFU- MK (P = .046), CFU-granulocyte, erythrocyte, monocyte, megakaryocyte (CFU-GEMM: P = .043), BFU-erythrocyte (BFU-E; P = .043), CFU- granulocyte, macrophage (CFU-GM; P = .045), and CFU-megakaryocyte (CFU- MK; P = .028) per milliliter of marrow was observed. Stromal cell-free LTBMCs supplemented with SCF and interleukin-3 (IL-3), initiated with CD34+ HLA-DR- CD15- cells obtained on day 0, produced viable cells for 9.6 weeks, compared with 11.5 weeks for LTBMCs initiated with CD34+ HLA- DR- CD15- cells obtained on day 15. Cumulative cellular production by LTBMCs initiated with day 15 CD34+ HLA-DR- CD15- cells was statistically greater than that by day 0 LTBMCs (P = .031). These same cultures produced CFU-GM for 6.3 weeks (day 0) versus 9 weeks (day 15).(ABSTRACT TRUNCATED AT 400 WORDS)
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Tong, J., MS Gordon, EF Srour, RJ Cooper, A. Orazi, I. McNiece, and R. Hoffman. "In vivo administration of recombinant methionyl human stem cell factor expands the number of human marrow hematopoietic stem cells." Blood 82, no. 3 (August 1, 1993): 784–91. http://dx.doi.org/10.1182/blood.v82.3.784.bloodjournal823784.
Повний текст джерелаАнотація:
A growing number of in vitro studies suggest that recombinant human stem cell factor (SCF) is capable of augmenting the proliferative capacity of human hematopoietic progenitor cells (HPC) and stem cells (HSC). We further evaluated this biologic effect by analyzing the response of bone marrow (BM) HPCs and HSCs to the administration of SCF in eight patients with locally advanced or metastatic breast cancer who were enrolled in an ongoing phase I study. SCF was administered for 14 days by daily subcutaneous injection at dosages of 10, 25, or 50 micrograms/kg/d. BM CD34+ HLA-DR+ and CD34+ HLA-DR- CD15- cells, previously shown by our laboratory to be enriched for various classes of differentiated and primitive HPCs, respectively, were quantitated in BM samples on day 0 (pretreatment) and day 15 (posttreatment). These CD34+ HLA-DR+ and CD34+ HLA-DR- CD15- cells were then isolated by cell- sorting and assayed for several classes of HPCs, including the high-- proliferative potential colony-forming cell (HPP-CFC), the burst- forming unit--megakaryocyte (BFU-MK), and the long-term BM culture-- initiating cell (LTBMC-IC). SCF administration resulted in a 3.3-fold (range, 1.4- to 18.8-fold; P = .018) increase in the absolute numbers of CD34+ cells, a 3.7-fold (range, 1.2- to 8.2-fold; P = .028) increase in the absolute numbers of CD34+ HLA-DR+ cells, and a 2.4-fold (range, 1.1- to 29.3-fold; P = .010) increase in the absolute numbers of CD34+ HLA-DR- CD15- cells. Following the infusion of SCF, a statistically significant increase in the absolute numbers of HPP-CFC (P = .018), BFU- MK (P = .046), CFU-granulocyte, erythrocyte, monocyte, megakaryocyte (CFU-GEMM: P = .043), BFU-erythrocyte (BFU-E; P = .043), CFU- granulocyte, macrophage (CFU-GM; P = .045), and CFU-megakaryocyte (CFU- MK; P = .028) per milliliter of marrow was observed. Stromal cell-free LTBMCs supplemented with SCF and interleukin-3 (IL-3), initiated with CD34+ HLA-DR- CD15- cells obtained on day 0, produced viable cells for 9.6 weeks, compared with 11.5 weeks for LTBMCs initiated with CD34+ HLA- DR- CD15- cells obtained on day 15. Cumulative cellular production by LTBMCs initiated with day 15 CD34+ HLA-DR- CD15- cells was statistically greater than that by day 0 LTBMCs (P = .031). These same cultures produced CFU-GM for 6.3 weeks (day 0) versus 9 weeks (day 15).(ABSTRACT TRUNCATED AT 400 WORDS)
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Kong, Kyoung Ae, Young Ju Suh, Su Jin Cho, Eun Ae Park, Mi Hye Park, and Young Ju Kim. "Association of Adiponectin Gene Polymorphism With Birth Weight in Korean Neonates." Twin Research and Human Genetics 16, no. 3 (April 3, 2013): 732–38. http://dx.doi.org/10.1017/thg.2013.16.
Повний текст джерелаАнотація:
Adiponectin has been associated with insulin resistance and type 2 diabetes mellitus and possibly fetal growth. Our aim was to assess the association between the single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and the birth sizes. We investigated four SNPs of ADIPOQ (rs182052, rs2241766, rs1501299, and rs266729) and birth height and weight in 237 healthy full-term neonates. The neonates with the rs182052 G allele had a greater birth weight (p = .043 in the dominant model) and a higher ponderal index (p = .028 in the additive model). The rs2241766 G allele was associated with a greater birth weight (p = .016 in the recessive model). In a logistic regression analysis, the homozygotes for the rs182052 G allele and those for the rs2241766 G allele showed a significant association with a greater birth weight above 90 percentile (OR 2.75, 95% CI 1.13–6.70 and OR 5.15, 95% CI 1.66–15.99, respectively). In conclusion, we found an association between rs182052 and rs2241766 and birth weight and ponderal index among healthy neonates and suggested that adiponectin might have some roles in fetal growth.
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Spunt, Sheri L., Catherine A. Poquette, Yasmeen S. Hurt, Alvida M. Cain, Bhaskar N. Rao, Thomas E. Merchant, Jesse J. Jenkins, Victor M. Santana, Charles B. Pratt, and Alberto S. Pappo. "Prognostic Factors for Children and Adolescents With Surgically Resected Nonrhabdomyosarcoma Soft Tissue Sarcoma: An Analysis of 121 Patients Treated at St Jude Children's Research Hospital." Journal of Clinical Oncology 17, no. 12 (December 1999): 3697–705. http://dx.doi.org/10.1200/jco.1999.17.12.3697.
Повний текст джерелаАнотація:
PURPOSE: The rarity and heterogeneity of pediatric nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) has precluded meaningful analysis of prognostic factors associated with surgically resected disease. To define a population of patients at high risk of treatment failure who might benefit from adjuvant therapies, we evaluated the relationship between various clinicopathologic factors and clinical outcome of children and adolescents with resected NRSTS over a 27-year period at our institution. PATIENTS AND METHODS: We analyzed the records of 121 consecutive patients with NRSTS who underwent surgical resection between August 1969 and December 1996. Demographic data, tumor characteristics, treatment, and outcomes were recorded. Univariate and multivariate analyses of prognostic factors for survival, event-free survival (EFS), and local and distant recurrence were performed. RESULTS: At a median follow-up of 9.2 years, 5-year survival and EFS rates for the entire cohort were 89% ± 3% and 77% ± 4%, respectively. In univariate models, positive surgical margins (P = .004), tumor size ≥ 5 cm (P < .001), invasiveness (P = .002), high grade (P = .028), and intra-abdominal primary tumor site (P = .055) adversely affected EFS. All of these factors except invasiveness remained prognostic of EFS and survival in multivariate models. Positive surgical margins (P = .003), intra-abdominal primary tumor site (P = .028), and the omission of radiation therapy (P = .043) predicted local recurrence, whereas tumor size ≥ 5 cm (P < .001), invasiveness (P < .001), and high grade (P = .004) predicted distant recurrence. CONCLUSION: In this largest single-institution analysis of pediatric patients with surgically resected NRSTS, we identified clinicopathologic features predictive of poor outcome. These variables should be prospectively evaluated as risk-adapted therapies are developed.
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Kursaev, A. V. "Civil Liability for Workplace Safety in Mining, Construction and Other Works: Technological and Legal Structure." Pravo: istoriya i sovremennost', no. 1 (2019): 028–43. http://dx.doi.org/10.17277/pravo.2019.01.pp.028-043.
Повний текст джерела
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WILSON, N., M. BOYD, S. NISA, C. CLEMENT, and M. G. BAKER. "Did exposure to a severe outbreak of pandemic influenza in 1918 impact on long-term survival?" Epidemiology and Infection 144, no. 15 (August 1, 2016): 3166–69. http://dx.doi.org/10.1017/s0950268816001606.
Повний текст джерелаАнотація:
SUMMARYThere is some suggestion that infection with pandemic influenza may increase long-term mortality risks. Therefore we aimed to determine if exposure to a severe outbreak of pandemic influenza on a troopship in 1918 impacted on lifespan in the survivors. The troopship with the outbreak cohort had 1107 personnel and the comparison cohort was from two contemporaneous troopships (1108 randomly selected personnel). Data were collected from online individual military files. The main finding was that there was no statistically significant difference in the lifespan of the outbreak cohort and the comparison cohort (means of 71·5 and 71·0 years, respectively). Indeed, the outbreak cohort was actually more likely to survive into the period from 1950 onwards (P = 0·036) and to participate in the Second World War (P = 0·043). There were no significant differences between the cohorts in terms of occupational class, but the comparison cohort had a higher proportion of rural occupations (33·3% vs. 27·0%, P < 0·001) and was very slightly older in mid-1918 (27·8 vs. 27·2 years, P = 0·028). In conclusion, this study found no support for the hypothesis that exposure to the 1918 influenza pandemic adversely impacted on the lifespan in the survivors, at least in this male and military-age population.
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Dubnov, Gal, and Naama W. Constantini. "Prevalence of Iron Depletion and Anemia in Top-level Basketball Players." International Journal of Sport Nutrition and Exercise Metabolism 14, no. 1 (February 2004): 30–37. http://dx.doi.org/10.1123/ijsnem.14.1.30.
Повний текст джерелаАнотація:
Iron depletion, with or without anemia, may have a negative effect on physical and mental performance. Even with current recognition of the problem, its incidence among athletes remains high. Most studies describe iron status in endurance athletes. This study examined the prevalence of iron depletion and anemia among male and female top-level basketball players. Adolescents and adults (N = 103) from 8 national basketball teams were screened for anemia and iron stores status, which included a complete blood count and levels of plasma ferritin, transferrin, and serum iron. Iron depletion, defined by a ferritin level below 20 μg/L, was found among 22% of study participants (15% in males vs. 35% in females, p = .019). Anemia was found among 25% of athletes (18% in males vs. 38% in females, p = .028). Iron deficiency anemia, defined by the presence of anemia, ferritin levels below 12 μg/L, and transferrin saturation below 16%, was found among 7% of players (3% in males vs. 14% in females, p = .043). In summary, a high prevalence of iron depletion, anemia, and iron deficiency anemia was found among basketball players of both genders. We recommend screening ballgame players for blood count and iron store status, and providing nutritional counseling and iron supplementation when necessary.
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Newton, Kathryn T., and Aaron Ashley. "Introducing the Interdisciplinary Nature of Health Care Through Case Study Models." Journal of Education and Training Studies 8, no. 1 (December 12, 2019): 20. http://dx.doi.org/10.11114/jets.v8i1.4600.
Повний текст джерелаАнотація:
Interprofessional education (IPE) is a critical area needed to improve the quality of healthcare. Stereotypes of other disciplines persist by healthcare workers, limiting the ability to work as a team. Knowledge of roles of healthcare professions is a key competency of IPE. An online, 12-week course was developed to introduce students to the interdisciplinary nature of healthcare through case study models. Through built-in links, students explore medical terminology, diagnostic testing, pathophysiology, treatment, and health professionals who work as a team to diagnose and treat the patient. A 24-question survey was administered to a convenience sample of 582 high school students. Results of paired-samples t-tests showed significant increases pre-training to post-training in: 1) knowledge of the different roles of health professionals, (n = 338, M = .71, SEM = .01) to post-training (M = .82, SEM = .01), t(337) = 11.08, p<.001, pη2 = .203, 2) and self-reported knowledge of roles of different health professions, pre-training (n = 338, M = 2.73, SEM = .30) to post-training (M = 3.60, SEM = .039), t(337) = 20.02, p < .001, pη2 = .543. Interestingly, students’ likelihood in a career in healthcare professions decreased significantly pre-training (n = 338, M = 4.30, SEM = .043) to post-training (M = 4.20, SEM = .06), t(337) = 2.21, p = .028, pη2 = .016. Introducing knowledge of health professions to this population may be critical in avoiding stereotypes before a student enters a chosen career path, increasing the likelihood of participation in interdisciplinary teams.
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Saffarzadeh, Mona, Chad E. Eckert, Deborah Nagle, Lauren S. Weaner, Gregory S. Waters, Edward A. Levine, and Ashley A. Weaver. "Pelvic and Lower Gastrointestinal Tract Anatomical Characterization of the Average Male." Surgical Innovation 26, no. 2 (November 12, 2018): 180–91. http://dx.doi.org/10.1177/1553350618812317.
Повний текст джерелаАнотація:
Objective. Colorectal surgeons report difficulty in positioning surgical devices in males, particularly those with a narrower pelvis. The objectives of this study were to (1) characterize the anatomy of the pelvis and surrounding soft tissue from magnetic resonance and computed tomography scans from 10 average males (175 cm, 78 kg) and (2) develop a model representing the mean configuration to assess variability. Methods. The anatomy was characterized from existing scans using segmentation and registration techniques. Size and shape variation in the pelvis and soft tissue morphology was characterized using the Generalized Procrustes Analysis to compute the mean configuration. Results. There was considerable variability in volume of the psoas, connective tissue, and pelvis and in surface area of the mesorectum, pelvis, and connective tissue. Subject height was positively correlated with mesorectum surface area (P = .028, R2 = 0.47) and pelvis volume ( P = .041, R2 = 0.43). The anterior-posterior distance between the inferior pelvic floor muscle and pubic symphysis was positively correlated with subject height ( P = .043, r = 0.65). The angle between the superior mesorectum and sacral promontory was negatively correlated with subject height ( P = .042, r = −0.65). The pelvic inlet was positively correlated with subject weight ( P = .001, r = 0.89). Conclusions. There was considerable variability in organ volume and surface area among average males with some correlations to subject height and weight. A physical trainer model created from these data helped surgeons trial and assess device prototypes in a controllable environment.
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Chekle, Belayneh, Tefera Tadesse, and Zerihun Birhanu. "Chronological Age and Training Age as Determinants of Soccer Specific Speeds." International Journal of Physical Education, Fitness and Sports 8, no. 4 (October 29, 2019): 108–16. http://dx.doi.org/10.26524/ijpefs19411.
Повний текст джерелаАнотація:
The main purpose of this study was to unveil how chronological and training age or maturity of soccer players relate or affect linear sprinting speed, repeated sprinting ability (RSA), and change-ofdirection speed (CODS) performance. Competitive soccer players at the Ethiopian national soccer league level participated in the study. A total of 88 volunteered soccer players (age, 22.25±2.27 years old; training age; 9.38±2.78 years) who were free from any kind of injury at the time of data collection completed the study protocol. While age was calculated using a player’s birth certificate, fitness performance was measured using specific test protocols for each fitness element. For credibility, fitness test was conducted on a weekly basis for about five consecutive weeks and the average was taken. Bivariate correlation, partial correlation and GLM analyses were used. The bivariate correlation showed that sprinting speed (r (88) = - .254, p=.017), CODS (r (88) = -216, p.043) and RSA best (r (88) = 0.235, p=.028) significantly correlated with age (p<.05). However, RSA total time, RSA average and RSA worst did not correlate with age. With training age, only CODS showed small, but significant negative correlation (r (88) = -.230, p=.031). While sprinting speed significantly correlated with maturity, other qualities that rely on the ability to produce the best performance repeatedly did not relate with age or training age. These findings suggest that speed and speed related performances depend on maturity and genetic make-up and these are less trainable qualities that may not significantly improve over time.
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Haile-Mariam, M., and H. Kassa-Mersha. "Genetic and environmental effects on age at first calving and calving interval of naturally bred Boran (zebu) cows in Ethiopia." Animal Science 58, no. 3 (June 1994): 329–34. http://dx.doi.org/10.1017/s000335610000725x.
Повний текст джерелаАнотація:
AbstractTwenty-four years of data from a Boran cattle breeding and improvement ranch in the Rift Valley of Ethiopia were used to study the influence of genetic and environmental factors on age at first calving (AFC) and calving interval (CD using an individual animal model.The mean AFC and Cl were 41-8 months and 442 days, respectively. The h2 values for AFC were 0·062 and 0·075 when estimated on the original and selected data, from which cows that did not calve after 5 years of age were deleted, respectively. The h2 values for CI were 0·037 and 0·043 when estimated on the original and selected data, from which cows with AFC higher than 5 years and CI longer than 2 years were deleted, respectively. The corresponding c2 values (ratio of permanent environmental variance to total) were 0·031 and 0·028 for the respective data sets. Parameter estimates of the original data from bivariate analysis were 0·012 (h2), 0·065 (h2), -0·054 and -0·176 for first CI, AFC, their genetic and environmental correlation, respectively. The h2 values estimated in a bivariate analysis of the first three CIs varied between 0·002 and 0·093. Year and season had significant effects on both traits. The annual genetic change for both traits was not significant while the solutions for year effects were highly variable. The regression of the solutions of year effects for AFC on year showed that it increased by about 10 days while the variation in CI was due to random year to year fluctuation.
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Petros, William P., Penelope J. Hopkins, Susan Spruill, Gloria Broadwater, James J. Vredenburgh, O. Michael Colvin, William P. Peters, Roy B. Jones, Jeff Hall, and Jeffrey R. Marks. "Associations Between Drug Metabolism Genotype, Chemotherapy Pharmacokinetics, and Overall Survival in Patients With Breast Cancer." Journal of Clinical Oncology 23, no. 25 (September 1, 2005): 6117–25. http://dx.doi.org/10.1200/jco.2005.06.075.
Повний текст джерелаАнотація:
Purpose To evaluate associations between patient survival, pharmacokinetics, and drug metabolism–related genetic polymorphisms in patients receiving a combination chemotherapy regimen for breast cancer. Patients and Methods A genotype association study was conducted on 85 chemotherapy-naïve patients with metastatic or inflammatory breast cancer that were evaluated for an extended period after receiving standard-dose chemotherapy followed by high-dose cyclophosphamide, cisplatin, and carmustine. Blood pharmacokinetics were evaluated, and DNA was genotyped for 29 polymorphisms in 17 drug metabolism genes. Results Patients with cyclophosphamide plasma exposures above the median (implying slower metabolic activation) had a shorter survival than those below the median (1.8 v 3.8 years, respectively; P = .042). Patients having a variant genotype of cytochrome P450 3A4 displayed higher blood concentrations of parent (inactive) cyclophosphamide with the second and third doses (P = .024 and .028, respectively) in addition to slower cyclophosphamide activation over the three doses (P = .031). Median survival for these patients was 1.3 years compared with 2.7 years for those without the variant (P = .043). Similar results were observed for patients carrying a genetic variant of P450 3A5. Median survival for patients with deletions of glutathione-S-transferase M1 gene was 3.5 v 1.5 years for patients with one or both copies (P = .041). Patients with a polymorphism in a gene regulating metallothionein had lower platinum concentrations and shorter survival (P = .033). Conclusion These data suggest that pretreatment evaluation of drug metabolism genes may explain some interindividual differences in both anticancer drug pharmacokinetics and response. The correlations found here may have implications for other commonly used anticancer drugs.
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Jamal, Basem. "Treatment of Parotid Non-Hodgkin Lymphoma: A Meta-Analysis." Journal of Global Oncology, no. 4 (December 2018): 1–6. http://dx.doi.org/10.1200/jgo.17.00071.
Повний текст джерелаАнотація:
Purpose This meta-analysis aimed to review the published outcomes of parotid non-Hodgkin lymphoma (NHL) pertaining to different treatment modalities. Materials and Methods A total of 48 journal articles published between 1993 and 2015, comprising 742 cases of parotid NHL, were initially evaluated. In total, 108 patients from 12 studies who had sufficient data for analysis, including age, tumor histopathology, treatment modality, and outcome at final follow-up, were included. Patients were randomly assigned to different categories on the basis of histopathology and treatment modality. Groups were compared using Kaplan-Meier survival curve analysis and the Mann-Whitney U test. Results Log-rank tests demonstrated that for early-stage (I and II) parotid NHL of all histopathology variants, radiation therapy significantly improved the survival rate versus chemotherapy ( P = .043), as well as combined treatment with chemotherapy and radiation therapy ( P = .023). For early-stage diffuse large B-cell lymphoma, combined treatment significantly improved survival versus single treatment ( P = .028). No treatment was received by seven patients with early-stage mucosa-associated lymphoid tissue lymphoma after undergoing parotidectomy. When the clinical outcomes of these patients were compared with those of other patients with the same histology who underwent further treatment, no significant differences were noted in survival outcomes. Conclusion Radiation therapy seems to be a valid treatment of early-stage parotid NHL. However, for diffuse large B-cell lymphoma, survival was higher with combined treatment versus single treatment. For early-stage parotid mucosa-associated lymphoid tissue lymphoma, complete excision of the tumor through superficial parotidectomy may have similar survival outcome.
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Chakravarti, A., K. Heydon, C. L. Wu, E. Hammond, A. Pollack, M. Roach, H. Wolkov, et al. "Loss of p16 Expression Is of Prognostic Significance in Locally Advanced Prostate Cancer: An Analysis From the Radiation Therapy Oncology Group Protocol 86–10." Journal of Clinical Oncology 21, no. 17 (September 1, 2003): 3328–34. http://dx.doi.org/10.1200/jco.2003.12.151.
Повний текст джерелаАнотація:
Purpose: The retinoblastoma (RB) cell cycle regulatory pathway is known to be deregulated in virtually all known human tumors. The protein product of the RB gene, pRB, and its upstream regulator, p16, are among the most commonly affected members of this pathway. We investigated the prognostic significance of both pRB and p16 expression in locally advanced prostate cancers, from patients treated on the Radiation Therapy Oncology Group (RTOG) protocol 86–10. Materials and Methods: Sixty-seven cases from RTOG 86–10 had immunohistochemically stained slides, judged interpretable for both p16 and pRB, available for analysis. Median follow-up was 8.9 years (range, 6.0 to 11.8 years) for surviving patients. Staining for each marker was then correlated with overall survival, local progression, distant metastasis, and disease-specific survival. Results: Loss of p16 expression, as defined by expression was significantly associated with reduced overall survival (P = .039), disease-specific survival (P = .006), and higher risk of local progression (P = .0007) and distant metastasis (P = .026) in the univariate analysis. In the multivariate analysis, loss of p16 was significantly associated with reduced disease-specific survival (P = .0078) and increased risk of local failure (P = .0035) and distant metastasis (P = .026). A borderline association with reduced overall survival (P = .07) was also evident. Loss of pRB was associated with improved disease-specific survival on univariate (P = .028) and multivariate analysis (P = .043), but carried no other significant outcome associations. Conclusion: Loss of p16 is significantly associated with adverse clinical outcome in cases of locally advanced prostate cancer.
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Murtagh, Conall F., Christopher Nulty, Jos Vanrenterghem, Andrew O’Boyle, Ryland Morgans, Barry Drust, and Robert M. Erskine. "The Neuromuscular Determinants of Unilateral Jump Performance in Soccer Players Are Direction-Specific." International Journal of Sports Physiology and Performance 13, no. 5 (May 1, 2018): 604–11. http://dx.doi.org/10.1123/ijspp.2017-0589.
Повний текст джерелаАнотація:
Purpose: To investigate differences in neuromuscular factors between elite and nonelite players and to establish which factors underpin direction-specific unilateral jump performance. Methods: Elite (n = 23; age, 18.1 [1.0] y; body mass index, 23.1 [1.8] kg·m−2) and nonelite (n = 20; age, 22.3 [2.7] y; body mass index, 23.8 [1.8] kg·m−2) soccer players performed 3 unilateral countermovement jumps (CMJs) on a force platform in the vertical, horizontal-forward, and medial directions. Knee extension isometric maximum voluntary contraction torque was assessed using isokinetic dynamometry. Vastus lateralis fascicle length, angle of pennation, quadriceps femoris muscle volume (Mvol), and physiological cross-sectional area (PCSA) were assessed using ultrasonography. Vastus lateralis activation was assessed using electromyography. Results: Elite soccer players presented greater knee extensor isometric maximum voluntary contraction torque (365.7 [66.6] vs 320.1 [62.6] N·m; P = .045), Mvol (2853 [508] vs 2429 [232] cm3; P = .001), and PCSA (227 [42] vs 193 [25] cm2; P = .003) than nonelite. In both cohorts, unilateral vertical and unilateral medial CMJ performance correlated with Mvol and PCSA (r ≥ .310, P ≤ .043). In elite soccer players, unilateral vertical and unilateral medial CMJ performance correlated with upward phase vastus lateralis activation and angle of pennation (r ≥ .478, P ≤ .028). Unilateral horizontal-forward CMJ peak vertical power did not correlate with any measure of muscle size or activation but correlated inversely with angle of pennation (r = −.413, P = .037). Conclusions: While larger and stronger quadriceps differentiated elite from nonelite players, relationships between neuromuscular factors and unilateral jump performance were shown to be direction-specific. These findings support a notion that improving direction-specific muscular power in soccer requires improving a distinct neuromuscular profile.
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Ihalainen, Johanna K., Oona Kettunen, Kerry McGawley, Guro Strøm Solli, Anthony C. Hackney, Antti A. Mero, and Heikki Kyröläinen. "Body Composition, Energy Availability, Training, and Menstrual Status in Female Runners." International Journal of Sports Physiology and Performance 16, no. 7 (July 1, 2021): 1043–48. http://dx.doi.org/10.1123/ijspp.2020-0276.
Повний текст джерелаАнотація:
Purpose: To determine body composition, energy availability, training load, and menstrual status in young elite endurance running athletes (ATH) over 1 year, and in a secondary analysis, to investigate how these factors differ between nonrunning controls (CON), and amenorrheic (AME) and eumenorrheic (EUM) ATH. Correlations to injury, illness, and performance were also examined. Methods: Altogether 13 ATH and 8 CON completed the Low Energy Availability in Females Questionnaire. Anthropometric, energy intake, and peak oxygen uptake assessments were made at 4 time points throughout the year: at baseline post competition season, post general preparation, post specific preparation, and post competition season the following year. Logs of physical activity, menstrual cycle, illness, and injury were kept by all participants. Performance was defined using the highest International Association of Athletics Federations points prior to and after the study. Results: ATH had significantly lower body mass (P < .008), fat percentage (P < .001), and body mass index (P < .027) compared with CON, while energy availability did not differ between ATH and CON. The Low Energy Availability in Females Questionnaire score was higher in ATH than in CON (P < .028), and 8 ATH (vs zero CON) were AME. The AME had significantly more injury days (P < .041) and ran less (P < .046) than EUM, while total annual running distance was positively related to changes in performance in ATH (r < .62, P < .043, n < 11). Conclusions: More than half of this group of runners was AME, and they were injured more and ran less than their EUM counterparts. Furthermore, only the EUM runners increased their performance over the course of the year.
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Bridge, Erica, Simron Singh, Amanda Murdoch, Mindaugas Mozuraitis, Brett Nicholls, and Lesley Moody. "Examining patient and visit characteristics associated with the cancer patient experience." Journal of Clinical Oncology 37, no. 27_suppl (September 20, 2019): 204. http://dx.doi.org/10.1200/jco.2019.37.27_suppl.204.
Повний текст джерелаАнотація:
204 Background: Your Voice Matters (YVM) is a 28-item patient experience survey for adult cancer outpatients undergoing treatment in Ontario.The purpose was to examine patient and visit characteristics associated with YVM responses. Methods: YVM was administered to eligible patients (n=8,704) at 14 centres in 2017.Respondents answered items on a five-point Likert scale (4 or 5 = positive response). A multivariable logistic regression (MLR) was undertaken for each YVM item.Variables (reference group) included: disease site (heamatology), age group (65+), sex (female), rurality (urban), last visit type (consult), income quintile(highest) and immigration tercile (lowest). Significant results ( p<.05) vary by MLR model. Therefore a p-value range is provided for all significant variables for all MLR models. Results: Patients were more likely to have a less positive experience if they had central nervous system ( p =.000-.013), gastrointestinal ( p =.004-.026), head and neck ( p =.002-.025), or lung cancer ( p =.017-.049); were between the ages of 18-39 years ( p = <.0001-.048); were female ( p =.0001-.022); received chemotherapy( p =.0001-.047); lived in a rural location ( p =.042); from a mid-( p =.027-.045) and mid-high income quartile ( p =.021); and in the high- ( p =.002-.043) and middle-immigrant terciles ( p =.028-.047), when compared to the reference group. Patient were more likely to have a more positive experience if they had skin cancer ( p =.004-.032); were between the ages of 40-64 years ( p =.003-.033); receiving radiation ( p =.0001-.041) or a minor procedure ( p =.015); and were from the mid-low ( p =.003-.042) and low income quartile ( p =.001-.032), when compared to the reference group. Conclusions: The cancer patient experience varies by patient and visit characteristics. Future initiatives should examine these characteristics to better understand their populations to create a more tailored approaches to cancer care.
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Irwin, Rebecca M., Yoshiharu Shimozono, Youichi Yasui, Robin Megill, Timothy W. Deyer, and John G. Kennedy. "Incidence of Coexisting Talar and Tibial Osteochondral Lesions Correlates With Patient Age and Lesion Location." Orthopaedic Journal of Sports Medicine 6, no. 8 (August 1, 2018): 232596711879096. http://dx.doi.org/10.1177/2325967118790965.
Повний текст джерелаАнотація:
Background: The incidence of coexisting osteochondral lesions (OCLs) of the tibia and talus has been negatively correlated with successful clinical outcomes, yet these lesions have not been extensively characterized. Purpose: To determine the incidence of coexisting tibial and talar OCLs, assess the morphologic characteristics of these lesions, and evaluate whether these characteristics are predictive of outcome. Study Design: Case series; Level of evidence, 4. Methods: A total of 83 patients who underwent surgery for a talar OCL were evaluated for coexisting OCLs of the distal tibia with preoperative magnetic resonance images. Size, location, containment, International Cartilage Repair Society (ICRS) grade, patient age, and patient sex were analyzed for predictors of coexisting lesions or patient outcome. The talar and tibial surfaces were each divided into 9 zones, with 1 corresponding to the most anteromedial region and proceeding laterally and then posteriorly. The Foot and Ankle Outcome Score (FAOS) was evaluated pre- and postoperatively. Results: Twenty-six patients (31%) had coexisting tibial and talar OCLs, with 9 (35%) identified as kissing lesions. Age correlated with coexisting lesion incidence, as older patients were more likely to have a coexisting tibial OCL ( P = .038). More than half of talar OCLs were found in zone 4 (61%), whereas the majority of tibial OCLs were located in zones 2, 4, and 5 (19% each). Patients with coexisting lesions were more likely to have a lateral talar OCL ( P = .028), while those without a coexisting tibial lesion were more likely to have a talar OCL in zone 4 ( P = .016). There was no difference in FAOS result or lesion size between patients with and without coexisting OCLs, but patients with coexisting lesions were more likely to have an ICRS grade 4 talar OCL ( P = .034). For patients with coexisting lesions, kissing lesions were more likely to be located in zone 6 ( P = .043). There was no difference in OCL size or containment between kissing and nonkissing coexisting OCLs. Conclusion: The incidence of coexisting talar and tibial OCLs may be more prevalent than what previous reports have suggested, with older patients being more likely to present with this pathology. The location of a talar OCL correlates with the incidence of a coexisting tibial OCL.
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Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. IV [Acid Salts] of the 4-Nitrophenoxides of Group 1." Australian Journal of Chemistry 51, no. 8 (1998): 747. http://dx.doi.org/10.1071/c97101.
Повний текст джерелаАнотація:
Room-temperature single-crystal X-ray studies are recorded for a number of ‘acid salts’ formed between Group 1 salts of 4-nitrophenol, M(4-np), and the parent ligand 4-npH, variously hydrated. The 1 : 1 salts M(4-np)(4-npH).x H2O are found for all of M = Li, Na, K, Rb and Cs. The lithium adduct (tetrahydrate) is monoclinic, C2/c, a 19·438(4), b 11·207(2), c 7·421(2) Å, β 91·38(2)°, Z = 4, conventional R on |F| being 0·043 for 1369 independent ‘observed’ (I > 3σ(I)) diffractometer reflections. The sodium adduct (dihydrate) is monoclinic, C2, a 2·174(3), b 3·674(2), c 10·358(1) Å, β 117·21(1)°, Z = 2, R 0·035 for No 1092; the potassium adduct (monohydrate) is monoclinic, C 2/c, a 22·10(1), b 3·798(3), c 21·270(6) Å, β 120·97(4)°, Z = 4, R 0·050 for No 1065. The isomorphous rubidium and caesium monohydrates are triclinic, P-1, a ≈ 11·9, b ≈ 10·2,c ≈ 6·3 Å, α ≈ 90, β ≈ 92, γ ≈ 112°, Z = 2, R 0·042, 0·028 for No 2340, 3053 respectively. For M = Rb, a 1 : 3 adduct Rb(4-np).3(4-npH) is also obtained (with an isomorphous thallium counterpart recorded elsewhere): a 12·143(5), b 11·50(1), c 11·36(1) Å, α 114·38(9), β 110·54(6), γ 96·73(6)°, Z = 2, R 0·034 for No 3945. The lithium salt may be represented as [Li(OH2)4]+ (4-npH.4-np)½-. The cation lies disposed about a crystallographic 2 axis; the anion, close to an axis, confronts its rotational image, with the associated hydrogen atom modelled as disordered between them, rather than located on the 2 axis. The sodium salt is a sheet structure, the six-coordinate sodium atoms being disposed on a crystallographic 2 axis and linked up that axis ... Na(µ-O)2Na(µ-O)2Na ... by bridging water molecule oxygen atoms, while symmetry-related trans O-nitrophenoxide moieties are bridged by confronting phenoxide oxygen atoms about an associated hydrogen atom provisionally disposed on a 2 axis also. The potassium salt structure is developed from this array, modelled with disordered potassium atoms, now lying off the 2 axis, 0·922(2) Å apart. In the rubidium/caesium structure, columns of oxygen-bridged metal ions are disposed about c, crosslinked by O-nitro-bonded phenoxide moieties, with confronting phenoxide oxygen atoms about a shared associated hydrogen.
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Barnes, Justin Michael, Eric Adjei Boakye, Mario Schootman, Evan Michael Graboyes, and Nosayaba Osazuwa-Peters. "Insurance coverage and care affordability in cancer survivors in 2016-2019." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 1520. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1520.
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1520 Background: The Affordable Care Act (ACA) led to improvements in insurance coverage and care affordability in cancer patients. However, the uninsured rate for the general US reached its nadir in 2016 and has been increasing since. We aimed to quantify the changes in insurance coverage and rate of care unaffordability in cancer survivors from 2016 to 2019. Methods: We queried data from the Behavioral Risk Factor Surveillance System (2016-2019) for cancer survivors ages 18-64 years. Outcomes of interest were the percentage of cancer survivors reporting insurance coverage and the percentage reporting cost-driven lack of care in the previous 12 months. Survey-weighted linear probability models adjusted for covariates (age, sex, race/ethnicity, income, education, marital status, and state Medicaid expansion status) were utilized to estimate the average yearly change (AYC) in the outcomes across 2016-2019. Mediation analyses evaluated the mediating effect of insurance coverage changes on changes in cost-driven lack of care. Results: A total of 178,931 cancer survivors were identified among the survey respondents. The percentage of insured cancer survivors between 2016 and 2019 decreased from 92.4% to 90.4% (AYC: -0.54, 95% CI = -1.03 to -0.06, P =.026). This translates to an estimated 164,638 cancer survivors in the United States who lost insurance coverage in the study period. There were decreases in private insurance coverage (AYC: -1.66, 95% CI = -3.1 to -0.22, P =.024) but increases in Medicaid coverage (AYC: 1.14, 95% CI = 0.03 to 2.25, P =.043). The decreases in any coverage were largest in individuals with income < 138% federal poverty level (FPL) (AYC: -1.14, 95% CI = -2.32 to 0.04, P =.059; compared to > 250% FPL, Pinteraction=.03). Cost-driven lack of care in the preceding 12 months among cancer survivors increased from 17.9% in 2016 to 20% in 2019 (AYC: 0.67, 95% CI = 0.06 to 1.27, P =.03), which translates to an estimated 167,184 survivors in the US who skipped care due to costs. Changes in insurance coverage mediated 27.5% of the observed change in care unaffordability overall (p =.028) and 65.7% in individuals with income < 138% FPL relative to > 250% FPL (p =.045). Conclusions: Between 2016 and 2019, about 165,000 cancer survivors in the United States lost their insurance coverage and a similar number may have skipped needed care due to cost. Loss of insurance coverage was mostly among individuals with low socioeconomic status. Interventions to improve health insurance coverage among cancer survivors, such as the recent executive order to strengthen the ACA and further efforts promoting Medicaid expansion in additional states, may be important factors to mitigate these trends.
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Elhadj Hammiche, El Hachemi. "Etude Anthropométrique Nationale Pour La Détection Des Jeunes Talents Sportifs En Algerie." مجلة العلوم الإنسانية, 2015, 87. http://dx.doi.org/10.34174/0079-000-043-028.
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عباس, أحمد هاشم. "New Issues Of Women Characters In Toni Morrison's The Bluest Eye And Sula." مجلة أبحاث البصرة للعلوم الإنسانية, 2018, 113. http://dx.doi.org/10.33762/0694-043-001-028.
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Hasan, Jasim Mohammed. "A Critical Discourse Analysis Of Rebert Ferrigno's Sins Of The Assassin." مجلة أبحاث البصرة للعلوم الإنسانية, 2018, 1. http://dx.doi.org/10.33762/0694-043-002-028.
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محمد, مهدي محسن, and فاطمة رسول عبدالله. "The Production Of Stance Triangle In Sport Discourse." مجلة أبحاث البصرة للعلوم الإنسانية, 2018, 38. http://dx.doi.org/10.33762/0694-043-003-028.
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قدري, صلاح الدين, та سعيد شوقي شكور. "السياحة الساحلية واستهلاك الحياة البحرية في الجزائر:, دراسة تقييمية للمخطط التوجيهي للتهيئة السياحية "SDAT 2025". مجلة العلوم الانسانية, 2016, 431. http://dx.doi.org/10.37136/1003-000-043-028.
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المصري, نعيم سمارة, та محمد محمد لافي. "التحكيم الشرعي - مجالاته وولاية الـمُـحَكَّم :, دراسة فقهية مقارنة". مجلة جامعة القدس المفتوحة للبحوث الإنسانية والاجتماعية, 2018, 46. http://dx.doi.org/10.33977/0507-000-043-028.
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ناصر, صهيب محمد. "المحبة والتسامح في فكر الإمام موسى بن جعفر الكاظم". مجلة آداب الفراهيدي, 2020, 423. http://dx.doi.org/10.51990/2228-012-043-028.
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تناح, الأمين, та الشايب ورنيقى. "التلقي العربي للتراث الشعري في ضوء النظرية السوسيولوجية". مجلة الإحياء, 2021, 719. http://dx.doi.org/10.35553/1699-021-028-043.
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Villar, Francisco, Carmina Castellano-Tejedor, Mireia Verge, Bernardo Sánchez, and Tomás Blasco-Blasco. "Predictors of Suicide Behavior Relapse in Pediatric Population." Spanish Journal of Psychology 21 (2018). http://dx.doi.org/10.1017/sjp.2018.7.
Повний текст джерелаАнотація:
AbstractIdentifying patients at increased risk of suicide remains a challenge today. It has been reported that 10% of patients committing a suicide attempt end up dying and that both the risk and the severity of clinical symptomatology increase with the number of attempts. Within the framework of selective and indicated prevention, it is essential to identify the group of patients with an increased risk of recurrence. The objective of this study is to identify factors predicting suicide attempt relapse to improve the decision making process in the therapeutic approach to suicidal behavior. The methodology employed was a longitudinal design aimed at identifying factors, in a binary logistic regression model (stepwise), predicting the repetition of suicidal behavior among a sample of 417 participants aged between 8 and 17 years old, at the six months follow-up. A statistically significant model χ2(3, N = 417) = 18.610; p < .001; Nagelkerke R2 = .096 including the following factors was obtained: current diagnosis of personality disorder/maladaptive personality OR = .806, p = .028, 95% CI [1.091, 4.595], personal history of self-injury OR = .728, p = .043, 95% CI [1.023, 4.192], and family history of psychopathological diagnosis OR = .925, p = .021, 95% CI [1.151, 5.530]. Considering these results, having a diagnosis of personality disorder or maladaptive personality traits, presence or history of self-harm and family history of psychopathology draws a predictive profile of autolytic attempt recurrence during the six months after the initial intervention at the emergency room.
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Matsumura, Noboru, Ryogo Furuhata, Takayuki Seto, Yuhei Takada, Hideyuki Shirasawa, Satoshi Oki, Yusuke Kawano, and Shohei Shiono. "Reproducibility of the modified Neer classification defining displacement with respect to the humeral head fragment for proximal humeral fractures." Journal of Orthopaedic Surgery and Research 15, no. 1 (September 23, 2020). http://dx.doi.org/10.1186/s13018-020-01966-2.
Повний текст джерелаАнотація:
Abstract Background Although the Neer classification is widely used for the assessment of proximal humeral fractures, its reproducibility has been challenged. The purpose of this study was to evaluate the reproducibility of the conventional Neer classification and a modified classification that defined fracture displacement with respect to the humeral head fragment. Methods The fracture patterns in 80 cases of proximal humeral fractures were independently assessed by 6 observers. The cases were grouped according to the conventional Neer classification using radiographs followed by computed tomography (CT) scans by each examiner twice with a 1-month interval. The fractures were then classified with the modified Neer classification, which defined displacement of the fragment as separation of more than 1 cm or angulation of more than 45° from the humeral head fragment, twice with a 1-month interval. Kappa coefficients of the conventional and modified Neer classifications were compared. Results The modified classification showed significantly higher intra-observer agreement than the conventional classification, both for radiographs (P = .028) and for CT scans (P = .043). Intra-observer agreement was also significantly higher for the modified classification than for the conventional classification, both for radiographs (P = .001) and for CT scans (P < .001). Conclusions The present study showed that agreement for the Neer classification could be improved when fracture displacement was defined as separation or angulation from the humeral head. Considering vascularity to the humeral head, furthermore, the modified method might be more helpful for predicting patients’ prognosis than the conventional Neer classification.
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Lever, Jonathon R., Dina C. Janse van Rensburg, Audrey Jansen van Rensburg, Peter Fowler, and Hugh H. K. Fullagar. "Subjective Sleep Patterns and Jet Lag Symptoms of Junior Netball Players Prior to and During an International Tournament: A Case Study." International Journal of Sports Physiology and Performance, 2021, 1–5. http://dx.doi.org/10.1123/ijspp.2021-0093.
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Purpose: To assess the impact of long-haul transmeridian travel on subjective sleep patterns and jet lag symptoms in youth athletes around an international tournament. Methods: An observational descriptive design was used. Subjective sleep diaries and perceived responses to jet lag were collected and analyzed for a national junior netball team competing in an international tournament. Sleep diaries and questionnaires were completed daily prior to and during travel, and throughout the tournament. Results were categorized into pretravel, travel, training, and match nights. Means were compared performing a paired Student t test with significance set at P < .05. Data are presented as mean (SD) and median (minimum, maximum). Results: Athletes reported significantly greater time in bed on match days compared with training (P < .001) and travel (P = .002) days, and on pretravel days compared with travel (P < .001) and training (P = .028) days. Sleep ratings were significantly better on pretravel days compared with match (P = .013) days. Perceived jet lag was worse on match (P = .043) days compared with pretravel days. Significant differences were also observed between a number of conditions for meals, mood, bowel activity, and fatigue. Conclusion: Youth athletes experience significantly less opportunity for sleep during long-haul transmeridian travel and face disruptions to daily routines during travel which impact food intake. Young athletes also experience disturbed sleep prior to and during competition. These results highlight the need for practices to alleviate jet lag symptoms and improve the sleep of young athletes traveling for tournaments in an effort to optimize recovery and performance.
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Ochi, Ryo, Ryosuke Tarumi, Yoshihiro Noda, Sakiko Tsugawa, Eric Plitman, Masataka Wada, Shiori Honda, et al. "Frontostriatal Structural Connectivity and Striatal Glutamatergic Levels in Treatment-Resistant Schizophrenia: An Integrative Analysis of DTI and 1H-MRS." Schizophrenia Bulletin Open 1, no. 1 (January 1, 2020). http://dx.doi.org/10.1093/schizbullopen/sgaa057.
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Abstract Given that approximately one-third of patients with schizophrenia do not respond to antipsychotics, different neurobiological bases may underlie treatment resistance in schizophrenia. Previous studies showed that treatment response is associated with both frontostriatal connectivity and glutamatergic neurometabolite levels in the caudate in patients with schizophrenia, which leads to the hypothesis that the relationship between them may be altered, specifically in patients with treatment-resistant schizophrenia (TRS). Employing analyses of covariance and subsequent partial correlation analyses, we compared the relationship between glutamate+glutamine (Glx) levels in the caudate and fractional anisotropy (FA) values in the tract between the dorsolateral prefrontal cortex and caudate in 19 patients with TRS, 20 patients responsive to first-line antipsychotics (FL-Resp), and 19 healthy controls (HCs). TRS was defined by severe positive symptomatology despite first-line antipsychotic treatment. Patients with TRS had lower FA values in the bilateral frontostriatal tracts than patients with FL-Resp and HCs (P < .001), while no group differences were found in caudate Glx levels. There was a significant frontostriatal FA value-by-group interaction on caudate Glx levels (F = 7.37, P = .009). Frontostriatal FA values positively correlated with caudate Glx levels in HCs (r = −.55, P = .028), while they were negatively associated with caudate Glx levels in the TRS group (r = .53, P = .043). Furthermore, in the FL-Resp group, frontostriatal FA values did not significantly correlated with caudate Glx levels. The altered relationship between white matter integrity and the glutamate system in the frontostriatal circuit in the TRS group may reflect the pathophysiology underlying treatment response/resistance in schizophrenia.
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Polgreen, Philip M., Grant D. Brown, Douglas B. Hornick, Ferhaan Ahmad, Barry London, David A. Stoltz, and Alejandro P. Comellas. "CFTR Heterozygotes Are at Increased Risk of Respiratory Infections: A Population-Based Study." Open Forum Infectious Diseases 5, no. 11 (November 1, 2018). http://dx.doi.org/10.1093/ofid/ofy219.
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Abstract Background Patients heterozygous for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene may be more susceptible to respiratory infections than the general population. Methods. We conducted a retrospective case–control study using health insurance claims. We identified patients as either highly likely to be CFTR heterozygotes (CF carriers diagnosed during genetic counseling, parents of children with a diagnosis of CF, and children of mothers diagnosed with CF) or likely CFTR heterozygotes (children of CF carriers diagnosed during genetic counseling and parents of CF carriers diagnosed during genetic counseling). Next, we examined the rates of respiratory infections and antimicrobial prescriptions between both groups of CFTR patients and only the highly likely subcohort, compared with age/sex-matched controls. We examined the presence of any claim using McNemar’s test and the number of claims using the sign test. Results CFTR heterozygotes (the pooled highly likely and likely heterozygotes) were more prone to have at least 1 claim for a respiratory infection (odds ratio [OR], 1.28; P = .020) and to have a greater number of claims for respiratory infections (53.5%; P = .043) than controls. Patients in the highly likely cohort were also more prone to have at least 1 claim for a respiratory infection (OR, 1.30; P = .028) and more claims (54.3%; P = .039) than controls. In addition, the highly likely CFTR heterozygotes were more prone to be prescribed an antibiotic used to treat respiratory infections (OR, 1.34; P = .018) and to have more of these prescriptions (54.3%; P = .035) than controls. Conclusions Patients heterozygous for CFTR mutations are at higher risk for respiratory infections. Future work to describe clinical outcomes for CFTR heterozygotes is needed.
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Nygaard, Rachel M., and Frederick W. Endorf. "Nonmedical Factors Influencing Early Deaths in Burns: A Study of the National Burn Repository." Journal of Burn Care & Research, August 17, 2019. http://dx.doi.org/10.1093/jbcr/irz139.
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Abstract It is well-established that survival in burn injury is primarily dependent on three factors: age, percent total-body surface area burned (%TBSA), and inhalation injury. However, it is clear that in other (nonburn) conditions, nonmedical factors may influence mortality. Even in severe burns, patients undergoing resuscitation may survive for a period of time before succumbing to infection or other complications. In some cases, though, families in conjunction with caregivers may choose to withdraw care and not resuscitate patients with large burns. We wanted to investigate whether any nonmedical socioeconomic factors influenced the rate of early deaths in burn patients. The National Burn Repository (NBR) was used to identify patients that died in the first 72 hours after injury and those that survived more than 72 hours. Both univariate and multivariate regression analyses were used to examine factors including age, gender, race, comorbidities, burn size, inhalation injury, and insurance type, and determine their influence on deaths within 72 hours. A total of 133,889 burn patients were identified, 1362 of which died in the first 72 hours. As expected, the Baux score (age plus burn size), and inhalation injury predicted early deaths. Interestingly, on multivariate analysis, patients with Medicare (p = .002), self-pay patients (p < .001), and those covered by automobile policies (p = .045) were significantly more likely to die early than those with commercial insurance. Medicaid patients were more likely to die early, but not significantly (p = .188). Worker’s compensation patients were more likely to survive the first 72 hours compared with patients with commercial insurance (p < .001). Men were more likely to survive the early period than women (p = .043). On analysis by race, only Hispanic patients significantly differed from white patients, and Hispanics were more likely to survive the first 72 hours (p = .028). Traditional medical factors are major factors in early burn deaths. However, these results show that nonmedical socioeconomic factors including race, gender, and especially insurance status influence early burn deaths as well.
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Reid, Amy J., Yuqiang Bai, Lorenzo F. Perez, Naomi Ogawa, L. M. Buja, Alvin T. Yeh, and Dianna M. Milewicz. "Abstract 508: Prolonged Thrombus Resolution Leading to Abnormal Collagen Fibrillogenesis and Angiogenesis in Injured Arteries of Type III Collagen-Deficient Mice: a Paradoxical Mechanism for ‘Tissue Fragility’ in Vascular Ehlers-Danlos Syndrome and Spontaneous Cervical Artery Dissection." Arteriosclerosis, Thrombosis, and Vascular Biology 33, suppl_1 (May 2013). http://dx.doi.org/10.1161/atvb.33.suppl_1.a508.
Повний текст джерелаАнотація:
Patients with COL3A1 mutations that impede secretion of type III collagen into matrix develop wounds that heal poorly following cutaneous injury. They are also predisposed to vascular complications like catastrophic rupture or dissection of cervical arteries and stroke. We sought to determine if low production of type III collagen would also interrupt arterial thrombus resolution, a process resembling wound healing, and whether defects contribute to risk of dissection. We injured cervical elastic arteries in mice by ligation of the left common carotid, halting proximal blood flow. Strikingly, injured arteries from Col3a1 +/- mice develop thrombi over three weeks that resist resolution more often than those in wild-type littermates ( p =.002). The unresolved thrombi in Col3a1 +/- arteries also retain a higher burden of macrophages ( p =.043) and proliferative α-actin-positive cells ( p =.034), while mutant arteries display vascular channels within the media ( p =.015) that are partially lined with endothelial cells, consistent with residual neoangiogenesis. At two weeks, burdens of macrophages ( p =.009), proliferative cells ( p =.028), and vascular channels ( p =.019) are also higher in Col3a1 +/- arteries, despite actively resolving thrombi of equal length between the two groups ( p =.338), suggesting that neoangiogenesis results specifically from lower Col3a1 dose. Treating injured mice with rapamycin halts thrombus resolution in the early inflammatory phase of both genotypes and normalizes the incidence of vascular channels in Col3a1 +/- arteries at three weeks ( p =1.00), suggesting that vascular channels result secondary to thrombus resolution and not from structural weakness in type III collagen deficient arteries. Patient-derived COL3A1 mutant myofibroblasts in 3D culture models of fibrin remodeling accumulate less extracellular type I collagen following TGFβ1 stimulation but persistently upregulate expression of Acta2 , relative to control cells whose Acta2 expression levels peak and subside as collagen accumulates by seven days. These data implicate dysregulated thrombus remodeling in response to injury that increases the risk for medial neoangiogenesis, which may also increase the risk for dissection in affected arteries after injury.
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Pratt, Rebecca, Donna Quinzi, and Rae-Ellen W. Kavey. "Abstract P182: Gender Difference in Response to Lifestyle Therapy in Obese Children with Combined Dyslipidemia." Circulation 125, suppl_10 (March 13, 2012). http://dx.doi.org/10.1161/circ.125.suppl_10.ap182.
Повний текст джерелаАнотація:
Combined dyslipidemia(CDL) [moderate to severe elevation in triglyceride (TG), decreased HDL-cholesterol (HDL), mild elevation in total (TC) and LDL-cholesterol (LDL)] is common in obese children. Primary treatment is lifestyle change. We reviewed the response to a standard staged approach in consecutive children with CDL referred to a pediatric cardiology prevention clinic who returned for follow-up(F/U). The clinical protocol uses the same physician/ registered dietitian team to prescribe a change in diet composition (fat free milk; no sugar-sweetened beverages; simple carbohydrates replaced with complex carbohydrates) and daily exercise (1/2 hr/d of moderate exercise beyond current activity). Patients return at 3 m intervals and are discharged when TG and LDL have normalized; calorie control and/or medication are not introduced until the primary approach has been unsuccessful at second F/U. Over the last 21 mos, 53 pts(52 % male) have been managed with this approach. At baseline (B/L), mean age was 12.9+3y with no significant difference between males(Ms) and females(Fs). In 94%, B/L BMI was > 95 th %ile. RESULTS (mean + SD): ALL F/U 1 F/U 2 MALE F/U 1 F/U 2 FEMALE F/U 1 F/U 2 B/L B/L B/L TC 213+38 194+42 190+41 208+33 187+39 186+40 220+42 202+44 195+42 TG 282+136 205+110 193+98 283+131 182+78 173+89 279+141 230+133 215+105 HDL 40+12 39+10 40+10 39+8 38+7 39+7 41+15 41+13 41+12 LDL 127+41 118+39 114+41 123+40 115+40 110+43 132+44 121+39 119+38 For all pts, there was a significant mean decrease in TC (p=.007) and TG (p=.001) at the first F/U visit, sustained at second F/U with no significant change in LDL or HDL. The mean decrease in TC was similar in Ms(p=.028) and Fs(p=.022) but decrease in TG was greater in Ms(39%)(p=.0003) than in Fs (23%)(p=.036) (p=.059 between Ms and Fs). At F/U 2, 50% of Ms vs 20% of Fs had normalized TC and TG levels (p=.043). Although there was no specific approach to weight loss, mean BMI decreased by 0.4 kg/m 2 , with no difference between Ms and Fs. CONCLUSIONS: (1) A simple lifestyle change focused on change in diet composition and daily exercise can significantly improve CDL in obese children on short term F/U, without weight loss; (2) Normalization of the lipid profile is significantly more common in Ms than Fs. If confirmed in a prospective trial, these are potentially important findings for this large and growing patient group.
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Valdés-Hernández, Pedro Antonio. "001 058 002 059 003 060 004 061 005 062 006 063 007 064 008 065 009 066 010 067 011 068 012 069 013 070 014 071 015 072 016 073 017 074 018 075 019 076 020 077 021 078 022 079 023 080 024 081 025 082 026 083 027 084 028 085 029 086 030 087 031 088 032 089 033 090 034 091 035 092 036 093 037 094 038 095 039 096 040 097 041 098 042 099 043 100 044 101 045 102 046 103 047 104 048 105 049 106 050 107 051 108 052 109 053 110 054 111 055 112 056 113 057 114 NEUROINFORMATICS METHODS ARTICLE published: xx November 2011 doi: 10.3389/fninf.2011.00026 An in vivo MRI template set for morphometry, tissue segmentation, and fMRI localization in rats." Frontiers in Neuroinformatics 5 (2011). http://dx.doi.org/10.3389/fninf.2011.00026.
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