Добірка наукової літератури з теми "Γ Peptide"
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Статті в журналах з теми "Γ Peptide"
Möller, Carolina, та Frank Marí. "A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8". Biochemical Journal 404, № 3 (29 травня 2007): 413–19. http://dx.doi.org/10.1042/bj20061480.
Повний текст джерелаMason, R. D., M. I. Bowmer, C. M. Howley, and M. D. Grant. "Cross-Reactive Cytotoxic T Lymphocytes against Human Immunodeficiency Virus Type 1 Protease and Gamma Interferon-Inducible Protein 30." Journal of Virology 79, no. 9 (May 1, 2005): 5529–36. http://dx.doi.org/10.1128/jvi.79.9.5529-5536.2005.
Повний текст джерелаHuang, Xiao-Li, Zheng Fan, LuAnn Borowski, and Charles R. Rinaldo. "Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells." Clinical and Vaccine Immunology 16, no. 10 (August 19, 2009): 1504–16. http://dx.doi.org/10.1128/cvi.00104-09.
Повний текст джерелаFlood, Veronica H., Hamid A. Al-Mondhiry, Antony C. Bakke та David H. Farrell. "Fibrinogen Hershey IV: A Novel Dysfibrinogen with a γ V411I Mutation in the Integrin αIibβ3 Binding Site." Blood 106, № 11 (16 листопада 2005): 2133. http://dx.doi.org/10.1182/blood.v106.11.2133.2133.
Повний текст джерелаFarrell, David H., Rehana S. Lovely та Lynn K. Boshkov. "Inhibition of Thrombin Cleavage of Factor VIII by Fibrinogen γ’ Chain Carboxyl Terminus." Blood 106, № 11 (16 листопада 2005): 1957. http://dx.doi.org/10.1182/blood.v106.11.1957.1957.
Повний текст джерелаHirano, Naoto, Marcus O. Butler, Zhinan Xia, Seiji Kojima та Lee M. Nadler. "γ-Globin, a Tumor-Associated Antigen for Juvenile Myelomonocytic Leukemia (JMML): A Cell-Based Approach To Identify Tumor Antigenic Epitopes That Are Naturally Processed and Presented." Blood 104, № 11 (16 листопада 2004): 3418. http://dx.doi.org/10.1182/blood.v104.11.3418.3418.
Повний текст джерелаHirao, Takashi, Masahide Sato, Akira Shirahata, and Yoshiyuki Kamio. "Covalent Linkage of Polyamines to Peptidoglycan inAnaerovibrio lipolytica." Journal of Bacteriology 182, no. 4 (February 15, 2000): 1154–57. http://dx.doi.org/10.1128/jb.182.4.1154-1157.2000.
Повний текст джерелаMujtaba, Mustafa. "Antiviral inducing properties of staphylococcal enterotoxin mimetic peptides (VAC9P.1065)." Journal of Immunology 194, no. 1_Supplement (May 1, 2015): 145.5. http://dx.doi.org/10.4049/jimmunol.194.supp.145.5.
Повний текст джерелаPassero, Christopher J., Marcelo D. Carattino, Ossama B. Kashlan, Mike M. Myerburg, Rebecca P. Hughey, and Thomas R. Kleyman. "Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel." American Journal of Physiology-Renal Physiology 299, no. 4 (October 2010): F854—F861. http://dx.doi.org/10.1152/ajprenal.00316.2010.
Повний текст джерелаZeng, Yi, Michael W. Graner, Sylvia Thompson, Marilyn Marron, and Emmanuel Katsanis. "Induction of BCR-ABL–specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cells." Blood 105, no. 5 (March 1, 2005): 2016–22. http://dx.doi.org/10.1182/blood-2004-05-1915.
Повний текст джерелаДисертації з теми "Γ Peptide"
Rosés, Subirós Cristina. "Solid-phase synthesis of cell-penetrating γ-peptide/antimicrobial peptide conjugates and of cyclic lipodepsipeptides derived from fengycins". Doctoral thesis, Universitat de Girona, 2016. http://hdl.handle.net/10803/393895.
Повний текст джерелаAquesta tesi doctoral s’ha centrat en el desenvolupament d’estratègies sintètiques útils per a l’obtenció de nous pèptids bioactius. Primerament, s’han dissenyat nous pèptids conjugats antitumorals a través de la unió d’un pèptid antimicrobià i un cell-pentrating peptide. Aquesta conjugació augmenta l’activitat antitumoral del pèptid mantenint la toxicitat baixa. Aquests conjugats són interessants pel desenvolupament de nous agents antitumorals. A continuació, s’ha desenvolupat una metodologia per a la preparació de pèptids cíclics derivats de les fengicines. Aquesta metodologia representa la primera estratègia sintètica descrita per a l’obtenció en fase sòlida d’aquesta família de ciclolipodepsipèptids i pot ser fàcilment adaptada per a l’obtenció d’una àmplia varietat d’anàlegs.
Halie, Delphine. "Synthèse diastéréosélective de mimes du peptide RGD." Paris 5, 2006. http://www.theses.fr/2006PA05P639.
Повний текст джерелаLi, Yaqiong. "Gamma AApeptides as Host Defense Peptide Mimics." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6301.
Повний текст джерелаShibata, Masayuki. "Studies on “kokumi” taste components in soybean seeds : Identification, content determination and efficient extraction." Kyoto University, 2018. http://hdl.handle.net/2433/233823.
Повний текст джерелаPardossi-Piquard, Raphaëlle. "Le complexe γ-sécrétase : implications dans la régulation de l'apoptose et la dégradation du peptide amyloïde". Nice, 2005. http://www.theses.fr/2005NICE4053.
Повний текст джерелаWan, Yang. "Synthesis of β,γ-diamino acids and their use to design new analogues of the antimicrobial peptide Gramicidin Septide antimicrobien, la Gramicidine S". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS407/document.
Повний текст джерелаIn our group, we are interested in developing peptides containing β,γ-diamino acids . Along with many other peptides containing unnatural amino acids, they have shown the ability to possess stable conformations and/or interesting biological activities. Moreover, those peptides are usually more resistant to proteolysis. In order to synthesize stereopure γ-amino acids, we have developed a synthetic route using Blaise reaction and subsequent diastereoselective reduction as key reactions. Through applying this method, we have synthesized β,γ-diamino acids derived from D-phenylalanine and L-glutamic acid. The former β,γ-diamino acid was used for designing antimicrobial peptide gramicidin S analogues. Compared with mother molecule, the analogues exerted much less host cell cytotoxicity while remaining interesting antibacterial activity. Meanwhile, it gave us more knowledge for further developing analogues of gramicidin S as well as other antimicrobial peptides. We also paid lots of effort to efficiently synthesize cyclic β,γ-diamino acids starting from L-glutamic acid. Interestingly, when oligomers incorporating this β,γ-diamino acids and α-amino acids, they have shown the potential to adopt stable conformations. The following studies will be continuously investigated
Nimmagadda, Alekhya. "Design, Synthesis, Applications of Polymers and Dendrimers." Scholar Commons, 2017. https://scholarcommons.usf.edu/etd/7430.
Повний текст джерелаAwada, Hawraà. "Synthèse sélective de γ-amino acides cyclobutaniques : préparation de nouveaux organogélateurs peptidiques". Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112365/document.
Повний текст джерелаThe γ-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS). In order to obtain new enantiomerically pure cyclobutanic derivative of GABA, the cis-3,4CB-GABA, two efficient synthetic strategies have been established. Both synthetic routes employed a photocycloaddition [2 +2] protocol, which provided the cyclobutanic ring. The first route involved the homolgation of the cis-2-aminocyclobutanecarboxylic acid (cis-ACBC), whereas the second route is a multi-step synthesis using caprolactam as starting material.On the other hand, the (1R,2S)-cis-GABA-2,3CB was synthetized, and a series of N- and C-protected oligomers of di, tri, and tetrapeptides of this amino acid were prepared. These oligomers were characterized by NMR (1D and 2D) techniques, IR, and X-ray. The analyses have shown that there are no non-covalent interactions (hydrogen bonds) between the residues of each oligomers. However, the gelation property of these oligomers in various organic solvents was demonstrated. Solutions and gels formed from these peptides were analyzed by scanning electron microscopy, and the obtained images showed a fibrous organization of the di- and tetrapeptide, while the tripeptide showed no regular intermolecular assembly
Chami, Linda. "Étude de la production du peptide amyloïde dans la maladie d'Alzeimer : régulations transcriptionnelles de la βAPP et des β- et γ-sécrétases". Nice, 2012. http://www.theses.fr/2012NICE4065.
Повний текст джерелаAlzheimer’s disease (AD) is characterized by memory loss, cognitive deficits and a loss of the patient’s autonomy. AD brains harbor senile plaques mainly composed of amyloid peptide (Aβ). This peptide likely contributes to the neurodegeneration. Aβ is produced by cleavage of its precursor βAPP by two enzymatic activities, the β- and the γ-secretase. Aβ is an important therapeutic target; we thus studied the transcriptionnal regulation of the proteins involved in its production. The transcription factor NF-κB is activated in Alzheimer’s disease. We show that NF-κB reduces Aβ production by inhibiting the transcription of βAPP and of the β- and γ-secretases. This regulation is complex, as in supraphysiological Aβ concentration, a condition close to the pathology, NF-κB is an activator of Aβ production. This suggests a positive feedback loop favoring Aβ production in pathological conditions. Neuronal death is characteristic of Alzheimer’s disease. We thus studied the regulation of Aβ production by the pro-apoptotic transcription factor p53. Our preliminary results indicate that p53 inhibits Aβ secretion. Finally we show a functional dialogue between the two secretases. Thus the γ-secretase cleavage of Notch-1 and of the epithelial and the neural cadherins regulates BACE1 transcription
Bakir, Ilyas. "Molecular studies of the γ-secretase complex activity and selectivity towards the two substrates APP and Notch". Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-9622.
Повний текст джерелаAlzheimer Disease (AD) is the most common neurodegenerative disorder in the world. One of the neuropathological hallmarks of AD is the senile plaques in the brain. The plaques are mainly composed of the amyloid β (Aβ) peptide. Aβ is generated from the amyloid precursor protein, APP, when it is first cleaved by the β-secretase and subsequently the γ-secretase complex. The γ-secretase complex cleaves at different sites, called γ and ε, where the γ-cleavage site generates Aβ peptides of different lengths and ε-cleavage generates the APP intracellular domain (AICD). The two major forms of Aβ is 40 and 42 amino acids long peptides, where the latter is more prone to aggregate and is the main component in senile plaques. The γ-secretase complex is composed of four proteins; Pen-2, Aph-1, nicastrin and presenilin (PS). The PS protein harbours the catalytic site of the complex, where two aspartate residues in position 257 and 385 (Presenilin 1 numbering) are situated. Most Familial AD (FAD) mutations in the PS gene cause a change in the γ-cleavage site, leading to a shift from producing Aβ40 to the longer more toxic variant Aβ42. Frequently, this often leads to impairments of the AICD production. Another substrate for the γ-secretase complex is Notch. It is important to maintain the Notch signaling since an intracellular domain (NICD) is formed after cleavage by the γ-secretase complex in the membrane (S3-site) and this domain is involved in transcription of genes important for cell fate decisions.
It has been reported that certain APP luminal juxtamembrane mutations could drastically alter Aβ secretion, however their effect on AICD production remains unknown. In this study we want to analyse wether the juxtamembrane region is important for the AICD production. To gain more insight into the luminal juxtamembrane function for γ-secretase-dependent proteolysis, we have made a juxtamembrane chimeric construct. A four-residue sequence preceding the transmembrane domain (TMD) of APP (GSNK), was replaced by its topological counterpart from the human Notch1 receptor (PPAQ). The resulting chimeric vector C99GVP-PPAQ and the wildtype counterpart were expressed in cells lacking PS1 and PS2 (BD8) together with PS1wt. We observed that the chimeric construct did not alter production of AICD when using a cell based luciferase reporter gene assay monitoring AICD production. We also introduced a PS1 variant lacking a big portion of the large hydrophilic loop, PS1∆exon10, since our group has previously observed that this region affect Aβ production143. We found that the absence of the large hydrophilic loop in PS1 gave a 2-fold decrease in AICD-GVP formation from C99GVPwt compared to PS1wt. The activity of PS1wt and PS1Δexon10 using C99GVP-PPAQ as a substrate gave similar result as the C99GVPwt substrate, i.e. a 2-fold decrease in AICD-GVP formation when comparing PS1Δexon10 with PS1wt. From this data we therefore suggest that the four residues in the juxtramembrane domain (JMD) (GSNK) is not altering ε-cleavage of APP when changed to Notch1 counterpart, PPAQ. Furthermore, we also show that the 2-fold decrease in AICD-production by the PS1Δexon10 molecule is not changed between the two substrates C99GVPwt and C99GVP-PPAQ. This indicates that the luminal region of APP is not directly involved in the ε-site processing. If the luminal region is affecting processing in the γ-cleavage sites, remains however to be investigated.
Частини книг з теми "Γ Peptide"
Zerkout, S., M. P. Golinelli, V. Grand, J. Vidal, A. Collet, A. Aubry, and M. Marraud. "Hydrazino peptide mimics of the γ- and β-turns." In Peptides 1994, 690–91. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-1468-4_317.
Повний текст джерелаNishiuchi, Yuji, Masayuki Nakao, Makoto Nakata, and Shumpei Sakakibara. "Synthesis of γ-carboxyglutamic acid-containing peptides by Boc strategy using HF for final deprotection." In Peptide Chemistry 1992, 61–64. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_18.
Повний текст джерелаFluhrer, Regina, and Christian Haass. "Intramembrane Proteolysis by γ-Secretase and Signal Peptide Peptidases." In Intracellular Traffic and Neurodegenerative Disorders, 11–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-87941-1_2.
Повний текст джерелаBernatowicz, Michael S., Catherine E. Costello, and Gary R. Matsueda. "Synthesis of an є-(γ-Glu) Lys cross-linked peptide in human fibrin." In Peptides, 187–88. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_53.
Повний текст джерелаNewlander, Kenneth A., James F. Callahan, Michael L. Moore, Thaddeus A. Tomaszek, and William F. Huffman. "A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the systematic incorporation of γ-turn mimetics into a model substrate." In Peptide Chemistry 1992, 535–37. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_156.
Повний текст джерелаBlumenstein, Michael, and Gary R. Matsueda. "Correlation of conformation with antibody affinity for fibrinogen γ-chain carboxyl terminal peptide segment." In Peptides, 237–38. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_82.
Повний текст джерелаvan Wickern, B., K. Kleeberg, D. Rogosch, and H. Steinhart. "Determination of Γ-Radiation Induced Products in Free and Peptide Bound Tryptophan." In Advances in Experimental Medicine and Biology, 649–53. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0381-7_105.
Повний текст джерелаMeister, Alton, Suresh S. Tate, and Gregory A. Thompson. "On the Function of the γ-Glutamyl Cycle in the Transport of Amino Acids and Peptides." In Ciba Foundation Symposium 50 - Peptide Transport and Hydrolysis, 123–50. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720318.ch8.
Повний текст джерелаv.d. Muelbe, Florian, Thomas Mothes, Holm Uhlig, A. A. Osman, Toni Weinschenk, Dietmar G. Schmid, Günther Jung, and Burkhard Fleckenstein. "Deamidation within a γ-Gliadin-Derived Peptide Enhances Its Recognition by Serum Antibodies of CD Patients." In Peptides: The Wave of the Future, 1037–38. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_485.
Повний текст джерелаKuroda, Motonaka, and Naohiro Miyamura. "Effect of a Kokumi Peptide, γ-Glutamyl-Valyl-Glycine, on the Sensory Characteristics of Foods." In Koku in Food Science and Physiology, 85–133. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8453-0_7.
Повний текст джерелаТези доповідей конференцій з теми "Γ Peptide"
Fresslnaud, E., J. E. Sadler, J. P. Girma, H. R. Baumgartner, and D. Meyer. "SYNTHETIC RGD-CONTAINING PEPTIDES OF VON WILLEBRAND FACTOR INHIBIT PLATELET ADHESION TO COLLAGEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643591.
Повний текст джерелаLam, S., E. F. Plow, A. L. Frelinger III, M. A. Smith, J. C. Loftus, and M. H. Ginsberg. "ARG-GLY-ASP (RGD) PEPTIDES INCREASE THE EXPOSURE OF THE CARBOXYL TERMINAL REGION OF THE HEAVY CHAIN OF GPIIB ON THE PLATELET SURFACE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643698.
Повний текст джерелаD’Souza, S. E., M. H. Ginaberg, S. Lam, and E. A. Plow. "ACTIVATION DEPENDENT ALTERATIONS IN THE CHEMICAL CROSSLINKING OF ARGINYL-GLYCYL-ASPARTIC ACID (RGD) PEPTIDES WITH PLATELET GLYCOPROTEIN (GP) GPIIb-IIIa." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643699.
Повний текст джерелаCierniewski, C. S., та A. Z. Budzynski. "CONFORMATIONAL EQUILIBRIA IN THE γ CHAIN COOH-TERMINUS OF HUMAN FIBRINOGEN". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642935.
Повний текст джерелаTerukina, S., M. Matsuda, N. Yoshida, K. Yamazumi, Y. Takeda та T. Takano. "TWO ABNORMAL FIBRINOGENS DESIGNATED AS OSAKA II AND MORIOKA WITH A HITHERTO UNIDENTIFIED AMINO ACID SUBSTITUTION; γARG-275 BY CYS". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644701.
Повний текст джерелаWilhelm, S., and A. Henschen. "ON THE IDENTIFICATION OF POLYMORPHIC SITES IN HUMAN FIBRINOGEN PEPTIDE CHAINS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643327.
Повний текст джерелаCharon, M. H., L. Tranqui, A. Andrieux, G. Hudry-Clergeon, and G. Marguerie. "FIBRINOGEN BINDING TO ENDOTHELIAL CELLS AND INTERFERING PEPTIDES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644735.
Повний текст джерелаSuttie, W. J., A. Cheung, and M. G. Wood. "ENZYMOLOGY OF THE VITAMIN K-DEPENDENT CARBOXYLASE: CURRENT STATUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643991.
Повний текст джерелаKuyas, C., H. Sigrist, and P. W. Straub. "LOCALIZATION CF FIBRIN POLYMERIZATION SITES BY PHOTQAFFINITY LABELING." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643776.
Повний текст джерелаHantgan, R. R. "LOCALIZATION OF THE DOMAINS OF FIBRIN INVOLVED IN BINDING TO PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643773.
Повний текст джерелаЗвіти організацій з теми "Γ Peptide"
Baszler, Timothy, Igor Savitsky, Christopher Davies, Lauren Staska, and Varda Shkap. Identification of bovine Neospora caninum cytotoxic T-lymphocyte epitopes for development of peptide-based vaccine. United States Department of Agriculture, March 2006. http://dx.doi.org/10.32747/2006.7695592.bard.
Повний текст джерела