Дисертації з теми "Β-defensin"
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Selim, Erik. "Solid-phase synthesis of Avian β-Defensin 8". Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-32076.
Повний текст джерелаAbujaber, Razan. "Phenotypic consequences of β-defensin copy number variation in humans". Thesis, University of Leicester, 2016. http://hdl.handle.net/2381/38814.
Повний текст джерелаOttolini, Barbara. "Evolution of copy number variation in the rhesus macaque β-defensin region". Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/28961.
Повний текст джерелаMeisch, Jeffrey P. "Human β-defensin 3 peptide is increased and redistributed in Crohn’s ileitis". Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270735950.
Повний текст джерелаZhang, Ke, та 张科. "Evaluation of anti-human respiratory syncytial virus effects of short interfering RNAs and β-defensin-4". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209570.
Повний текст джерелаpublished_or_final_version
Microbiology
Doctoral
Doctor of Philosophy
Telford, Erica. "Dual role of three natural molecules in regulating the expression of β-defensin-3 and pro-inflammatory mediators". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC273.
Повний текст джерелаAntimicrobial peptides (AMPs) are innate immune effectors produced and secreted by intestinal epithelial cells at the microbe-epithelium interface, where they represent an important component of the mucosal barrier. Some AMPs, such as human beta defensin (HBD)-1, are constitutively expressed, while others, including HBD-2 and HBD-3, are induced by a broad range of microbial- and host-derived signals. AMPs control the density of luminal commensal bacteria and invasive capacities of pathogens and have a role in perpetuating the innate immune response and inducing the adaptive response. Indeed, they present antimicrobial, immunoregulatory, angiogenic and anti-tumor effects, among the others. Little is known about regulation of AMP expression, but its deregulation has been associated with several human pathologies, including inflammatory bowel diseases, highlighting their crucial role in maintaining the homeostasis. Due to their multifaceted activities, AMPs represent an appealing therapeutic target for developing novel or complementary solutions to antibiotics, to face the emergence of infectious diseases in public health and the crisis of antimicrobial resistance, and to help re-establishing homeostasis in inflammatory diseases.By screening a bank of natural molecules, our team identified three promising targets, andrographolide (AND), isoliquiritigenin (ISL) and oridonin (ORD), which increase the expression of HBD-3 without inducing pro-inflammatory genes. This project thoroughly studied the effect of AND, ISL and ORD on inducing expression of HBD-3 in an in vitro model of intestinal epithelial cells. These molecules not only produced this effect when used alone, but also acted synergistically, highly inducing the expression of HBD-3 when used in combination. Moreover, AND, ISL and ORD hindered the expression of the pro-inflammatory genes IL-1β, IL-6, IL-8 and TNF-α upon stimulation of cells with endogenous or bacterial inflammatory stimuli. Further studies conducted by the group aimed at characterizing the activity of the compounds in vitro and ex vivo and unravelling their mechanisms of action by studying the intracellular pathways involved.In conclusion, AND, ISL and ORD represent useful tools to study the regulatory network controlling expression of AMPs and might develop to be candidate drugs for pathologic conditions in which strengthening the mucosal barrier, while reducing inflammation, is needed
Steiner, Tamara Alice [Verfasser]. "Die Bedeutung des humanen β-Defensin-3 für die Infektion von humanem respiratorischem Epithel mit Moraxella catarrhalis / Tamara Alice Steiner". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052221475/34.
Повний текст джерелаPahl, René [Verfasser]. "Rolle von IL-1β und ADAM17 in der Regulation der β-Defensin-Antwort im Rahmen der Candida-Ösophagitis / René Pahl". Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1041255527/34.
Повний текст джерелаReynolds, Natalie Louise. "Functional studies of vertebrate β-defensins". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/27262.
Повний текст джерелаRolfe, Mark J. "The antibacterial and chemoattractant activities of murine β-defensins". Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/27300.
Повний текст джерелаSyed, Mobin. "Role of human β-defensins in human burn wounds". Thesis, University of Westminster, 2009. https://westminsterresearch.westminster.ac.uk/item/90zx8/role-of-human-defensins-in-human-burn-wounds.
Повний текст джерелаDe, Cecco Martin. "Biophysical studies to elucidate structure-activity relationships in β-defensins". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4931.
Повний текст джерелаALMEIDA, Felipe Rodrigues de. "Associação dos polimorfismos da β-defensina 1 em pacientes com periodontite crônica". Universidade Federal de Pernambuco, 2017. https://repositorio.ufpe.br/handle/123456789/25457.
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CAPES
Variações genéticas do gene que codifica as β-defensinas podem influenciar a susceptibilidade às infecções, inclusive à periodontite crônica. Este estudo teve como objetivo, verificar a associação de polimorfismos genéticos da β-defensina 1 (-52; -44; -20) em pacientes portadores de periodontite crônica comparados à periodontalmente saudáveis. Nesta análise clínico-laboratorial, participaram pacientes provenientes das clínicas integrais do curso de Odontologia da Universidade Federal de Pernambuco (UFPE) e dos ambulatórios do Hospital Agamenon Magalhães (HAM), no período de novembro de 2015 a outubro de 2016, os quais obedeceram os critérios de inclusão e exclusão adotados. Os participantes foram divididos em 02 grupos: portadores de periodontite crônica (GP=95) e periodontalmente saudáveis (GC=69). Inicialmente foram coletados dados sóciodemográficos (nome, idade, gênero, estado civil, renda salarial, escolaridade) e clínicos dos pacientes (profunidade de sondagem (PS), nível de inserção clínica (NIC) e índice de sangramento à sondagem (ISS)). Além disso, foram coletadas amostras de saliva total espontânea, as quais foram submetidas à isolamento e purificação do ADN e genotipagem por reação em cadeia da polimerase em tempo real (RCP-TR), para verificação da presença de polimorfismos de única base (SNPs) da β-defensina 1(-52; -44; -20). O teste exato de Fisher foi utilizado para verificar associações entre os dados de PS, NIC e ISS e os genótipos investigados. O nível de significância adotado foi de 5% e intervalo de confiança de 95%. Ambos os polimorfismos da β-defensina 1 (-52, -44 e -20) foram observados em pacientes com periodontite crônica, contudo, apenas o SNP (-20) apresentou diferença estatística entre os grupos GP e GC (p<0,05). Para o SNP (-20), o alelo A apresentou-se em mais da metade do GP (p<0,000) e o genótipo AA foi mais frequente neste grupo (p<0,000). Verificou-se que a razão de chances de um paciente com periodontite crônica apresentar o genótipo AA foi 14,15 vezes maior do que em periodontalmente saudáveis. Quanto à freqüência haplotípica, a maior freqüência foi de GCA (p<0,000), seguido de ACA no grupo GP (p<0,000). Apenas o genótipo GG do SNP (-44) apresentou resultado significativo para a variável NIC (p<0,017). Portanto, o estudo sugere que o SNP (-20) parece influenciar na predisposição da periodontite crônica, sendo o genótipo AA mais presente nos indivíduos com periodontite crônica, assimo como, os haplótipos GCA e ACA estão mais presentes em pacientes com periodontite crônica comparados a periodontalmente saudáveis.
Genetic variations of gene that encoding β-defensins may influence the susceptibility to infections, including chronic periodontitis. This study aimed to verify the association of genetic polymorphisms of β-defensin 1 (-52; -44; -20) in patients with chronic periodontitis compared to periodontally healthy. In this clinical-laboratorial analysis participated in the study patients from dental clinics of Federal University of Pernambuco (FUPE) and outpatient clinics of Agamenon Magalhães Hospital (AMH), from november 2015 to october 2016, which obeyed the inclusion and exclusion criteria adopted. Participants were divided into 2 groups: patients with chronic periodontitis (PG = 95) and periodontally healthy (CG = 69). Initially, were collected socio-demographic data (name, age, gender, marital status, salary income, schooling) and clinical status of the patients (depth of probing (DP), clinical insertion level (CIL) and bleeding probing index (BPI)). In addition, samples of spontaneous total saliva were collected, which were submitted to DNA isolation and purification and genotyping by real-time polymerase chain reaction (RT-PCR) to verify the presence of single-base polymorphisms (SNPs) of β-defensin 1 (-52; -44; -20). The Fisher´s exact test was used to verify associations between DP, CIL and BPI data and the investigated genotypes. The significance level was 5% and 95% confidence interval. Both polymorphisms of β-defensin 1 (-52; -44; -20) were observed in patients with chronic periodontitis; however, only SNP (-20) presented statistical difference between PG and CG groups (p <0.05 ). For SNP (-20), “A” allele was present in more than half of PG (p <0,000) and “AA” genotype was more frequent in this group (p <0.000). It was verified that the odds ratio of a patient with chronic periodontitis presenting “AA” genotype was 14.15 times higher than periodontally healthy subjects. As to the haplotype frequency, the highest frequency was “GCA” (p <0.000), followed by “ACA” in PG group (p <0.000). Only “GG” genotype of SNP (-44) presented a significant result for CIL variable (p <0.017). Therefore, the study suggests that SNP (-20) seems to influence the predisposition of chronic periodontitis, with “AA” genotype being more present in individuals with chronic periodontitis, as “GCA” and “ACA” haplotypes are more present in patients with chronic periodontitis compared to periodontally healthy.
Anhuef, Ole [Verfasser]. "Antimikrobielle Wirkung des humanen β-Defensins 2 gegen Escherichia coli / Ole Anhuef". Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1237684323/34.
Повний текст джерелаDIAS, Rayanne Soraia Aguiar de Melo. "Análise dos polimorfismos da β-defensina-1 em diabéticos tipo 2 com periodontite crônica". Universidade Federal de Pernambuco, 2017. https://repositorio.ufpe.br/handle/123456789/25650.
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A íntima relação entre Diabetes Mellitus (DM) e Periodontite Crônica (PC) é foco de várias investigações na literatura. Alguns mecanismos fisiopatológicos explicam essa relação; porém, o papel de variações genéticas em genes relacionados a resposta imune inata, neste contexto, ainda não é claro e se mostra como um caminho para trazer novas informações. Considerando a importância do gene da β-defensina-1 na imunidade inata, primeira linha de defesa do organismo contra infecções, e supondo que polimorfismos de única base (SNPs) neste podem influenciar a susceptibilidade às infecções, o presente trabalho teve como objetivo avaliar a distribuição de SNPs funcionais do gene DEFB1 em indivíduos com diabetes mellitus tipo 2 (DM2) com PC e indivíduos saudáveis (controles), além da sua possível associação com o desenvolvimento de PC em portadores de DM2. Ao todo, 185 indivíduos participaram do estudo, sendo 116 com DM2 e PC e 69 indivíduos saudáveis para essas duas condições (grupo controle). Três SNPs funcionais (-52 G>A [rs1799946], -44 C>G [rs1800972] e -20 G>A [rs11362]) foram genotipados pela técnica de Reação em Cadeia da Polimerase (PCR) em tempo real, usando sondas alelo específicas (TaqMan®). As distribuições dos genótipos nos SNPs de DEFB1 estavam condizentes com o Equilíbrio de Hardy-Weinberg, exceto para o SNP rs1800972 nos indivíduos controles. Os resultados mostraram uma associação significativa para o SNP na posição -20 G>A de DEFB1. O alelo G e os genótipos GA e GG foram significativamente (p<0.05) mais frequentes entre indivíduos DM2 com PC (59,5%, 50% e 34,5%, respectivamente) que indivíduos saudáveis (26,8%, 36,2% e 8,7%, respectivamente). Quanto aos haplótipos, observou-se que as combinações GCG e ACG (-52,-44,-20) também foram mais frequentes entre os indíviduos DM2 com PC (28% e 23,3%, respectivamente) que em indivíduos controles (15,2% e 6,5%, respectivamente). Adicionalmente, também verificou-se associações significativas da distribuição dos genótipos do SNP na posição -20 em relação a severidade (p=0.021) e a classificação da PC (0.046). Diante disso, sugere-se que o alelo G, os genótipos GA e GG no SNP -20 G>A e os haplótipos GCG e ACG podem estar associados com uma maior susceptibilidade para o desenvolvimento de PC em diabéticos tipo 2 em uma população do nordeste do Brasil.
The close relation between Diabetes Mellitus (DM) and Chronic Periodontitis (CP) is the focus of several investigations in the literature. Some pathophysiological mechanisms explain this relation; nevertheless, the role of genetic variations in genes related to innate the immune response, in this context, is still not clear and has shown to be a way to bring new information. Considering the importance of the β-defensin-1 gene in the innate immunity, the first line of defence against infections, and assuming that single base polymorphisms (SNPs) in this gene could influence on the susceptibility to infections, the current study aimed evaluate the distribution of functional SNPs of DEFB1 gene in DM type 2 individuals with CP and healthy individuals (controls) and their possible association with the development of CP in type 2 DM carriers. Altogether, 185 individuals participated in this study, of which 116 were type 2 DM and CP carriers, and 69 were healthy individuals in what regards both conditions studied (control group). Three functional SNPs (-52 G>A [rs1799946], -44 C>G [rs1800972] e -20 G>A [rs11362]) were genotyped by the real-time polymerase reaction (PCR) technique using specific allele probes (TaqMan®). The distributions of the genotypes in the DEFB1 SNPs were consistent with the Hardy-Weinberg Equilibrium, except for the SNP rs1800972 in the control individuals. Results showed a significant association for the SNP at the -20 G>A position of DEFB1. The G allele and GA and GG genotypes were significantly (p<0.05) more frequent among DM2 individuals with CP (59.5%, 50% and 34.5%, respectively) than healthy individuals (26.8%, 36.2% and 8.7%, respectively). Regarding the haplotypes, it was observed that the GCG and ACG combinations (-52, -44, -20) were also more frequent among PC type 2 DM patients with PC (28% and 23.3%, respectively) than in controls (15.2% and 6.5%, respectively). In addition, we also found significant associations of the distribution of the SNP genotypes at position -20 in relation to severity alone (p=0.021) and PC severity / extension (p=0.046). Therefore, it is suggested that the G allele, the GA and GG genotypes in the -20 G>A SNP and the GCG and ACG haplotypes may be associated with a greater susceptibility to the development of PC in type 2 diabetics in a population in the northeast of Brazil.
Luya, Estrada Leys Anita [Verfasser]. "Die Expression von β-Defensinen in menschlichen Haarfollikeln / Leys Anita Luya Estrada". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1133492797/34.
Повний текст джерелаNoda, Nathália Mayumi [UNESP]. "β Defensinas em membranas corioamnióticas de gestações complicadas por prematuridade: expressão gênica e imunolocalização". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/95862.
Повний текст джерелаEventos inflamatórios na interface mateno-fetal estão pronunciados em gestações complicadas por prematuridade e a corioamnionite é reconhecida como a principal causa de morbimortalidade perinatal. As membranas corioamnióticas desempenham papel fundamental na imunidade inata local e inibem o crescimento de micro-organismos, em parte, pela expressão de β defensinas humanas (HBDs). Essas moléculas são antimicrobianos naturais que apresentam atividade antibatcteriana, antifúngica e antiviral e são produzidas por células epiteliais. Quantificar a expressão gênica e avaliar a imunolocalização de HBD-1, HBD-2 e HBD-3 em membranas corioamnióticas de gestações complicadas por prematuridade. Trata-se de um estudo prospectivo e transversal. Fragmentos das membranas corioamnióticas foram coletadas de gestantes atendidas no Serviço de Obstetrícia do Hospital das Clínicas da Faculdade de Medicina de Botucatu, UNESP, Botucatu, São Paulo, Brasil. O grupo estudo foi constituído por 25 membranas corioamnióticas de gestantes em Trabalho de Parto Prematuro na presença ou não de Rotura Prematura de Membranas Pré-Termo que tiveram parto prematuro como desfecho gestacional. Como grupo controle, 27 membranas corioamnióticas de gestações de termo em trabalho de parto foram analisadas. Fragmentos das membranas corioamnióticas foram fixadas em formalina a 10%, embebidas em parafina e seccionadas para análise da imunolocalização de HBD-1, HBD-2 e HBD-3 pela técnica de imunoistoquímica. Outros fragmentos das membranas corioamnióticas foram congelados em nitrogênio líquido e submetidos à extração do RNA total para posterior quantificação da expressão de RNAm de HBD-1, HBD-2 e HBD-3 empregando-se a técnica de PCR em tempo real utilizando o sistema TaqMan Gene Expression Assays (Applied Biosystems). Os resultados obtidos no estudo foram submetidos aos testes z e de Mann Whitney. O software empregado...
Inflammatory events can be pronounced in the maternal-fetal interface in pregnancies complicated by prematurity and chorioamnionitis is a major cause of perinatal morbidity and mortality. The chorioamniotic membranes play fundamental role in the local innate immunity and inhibit the microorganisms growth, partly by the expression of human β defensins (HBDs). These molecules are natural antimicrobials that present antibacterial, antifungal and antiviral activities and are produced by epithelial cells. To quantify the expression and to evaluate the immunolocalization of HBD-1, HBD-2 and HBD-3 in chorioamniotic membranes from pregnancies complicated by prematurity. This was a prospective controlled study. Fragments of chorioamniotic membranes were collected from pregnant women admitted at the Obstetrics Unit of the Clinical Hospital of the Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil. The study group consisted of 25 chorioamniotic membranes samples from pregnant women with preterm labor, in the presence or not of Preterm Premature Rupture of Membranes (PPROM), who delivery prematurely. In the control group, 27 chorioamniotic membranes from pregnancies at term in the presence at labor were analysed. Samples of the chorioamniotic membranes were fixed in 10% formalin, embedded in paraffin and sectioned for immunolocalization of HBD-1, HBD-2 and HBD-3 by immunohistochemistry technique. Other chorioamniotic membranes samples were collected in liquid nitrogen and total RNA was extracted to quantify mRNA expression of HBD-1, HBD-2 and HBD-3 using real time quantitative PCR employing the TaqMan Gene Expression Assays (Applied Biosystems). Statistical analyses were performed using z and Mann Whitney tests in SigmaStat Software and the level of significance adopted was of 5%. In relation to demographic and obstetrics data no statistically significant difference concerning maternal ...
Noda, Nathália Mayumi. "β Defensinas em membranas corioamnióticas de gestações complicadas por prematuridade : expressão gênica e imunolocalização /". Botucatu, 2013. http://hdl.handle.net/11449/95862.
Повний текст джерелаBanca: Rosane Ribeiro Figueiredo Alves
Banca: Luciane Alarcão Dias Melício
Resumo: Eventos inflamatórios na interface mateno-fetal estão pronunciados em gestações complicadas por prematuridade e a corioamnionite é reconhecida como a principal causa de morbimortalidade perinatal. As membranas corioamnióticas desempenham papel fundamental na imunidade inata local e inibem o crescimento de micro-organismos, em parte, pela expressão de β defensinas humanas (HBDs). Essas moléculas são antimicrobianos naturais que apresentam atividade antibatcteriana, antifúngica e antiviral e são produzidas por células epiteliais. Quantificar a expressão gênica e avaliar a imunolocalização de HBD-1, HBD-2 e HBD-3 em membranas corioamnióticas de gestações complicadas por prematuridade. Trata-se de um estudo prospectivo e transversal. Fragmentos das membranas corioamnióticas foram coletadas de gestantes atendidas no Serviço de Obstetrícia do Hospital das Clínicas da Faculdade de Medicina de Botucatu, UNESP, Botucatu, São Paulo, Brasil. O grupo estudo foi constituído por 25 membranas corioamnióticas de gestantes em Trabalho de Parto Prematuro na presença ou não de Rotura Prematura de Membranas Pré-Termo que tiveram parto prematuro como desfecho gestacional. Como grupo controle, 27 membranas corioamnióticas de gestações de termo em trabalho de parto foram analisadas. Fragmentos das membranas corioamnióticas foram fixadas em formalina a 10%, embebidas em parafina e seccionadas para análise da imunolocalização de HBD-1, HBD-2 e HBD-3 pela técnica de imunoistoquímica. Outros fragmentos das membranas corioamnióticas foram congelados em nitrogênio líquido e submetidos à extração do RNA total para posterior quantificação da expressão de RNAm de HBD-1, HBD-2 e HBD-3 empregando-se a técnica de PCR em tempo real utilizando o sistema TaqMan Gene Expression Assays (Applied Biosystems). Os resultados obtidos no estudo foram submetidos aos testes z e de Mann Whitney. O software empregado ...
Abstract: Inflammatory events can be pronounced in the maternal-fetal interface in pregnancies complicated by prematurity and chorioamnionitis is a major cause of perinatal morbidity and mortality. The chorioamniotic membranes play fundamental role in the local innate immunity and inhibit the microorganisms growth, partly by the expression of human β defensins (HBDs). These molecules are natural antimicrobials that present antibacterial, antifungal and antiviral activities and are produced by epithelial cells. To quantify the expression and to evaluate the immunolocalization of HBD-1, HBD-2 and HBD-3 in chorioamniotic membranes from pregnancies complicated by prematurity. This was a prospective controlled study. Fragments of chorioamniotic membranes were collected from pregnant women admitted at the Obstetrics Unit of the Clinical Hospital of the Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil. The study group consisted of 25 chorioamniotic membranes samples from pregnant women with preterm labor, in the presence or not of Preterm Premature Rupture of Membranes (PPROM), who delivery prematurely. In the control group, 27 chorioamniotic membranes from pregnancies at term in the presence at labor were analysed. Samples of the chorioamniotic membranes were fixed in 10% formalin, embedded in paraffin and sectioned for immunolocalization of HBD-1, HBD-2 and HBD-3 by immunohistochemistry technique. Other chorioamniotic membranes samples were collected in liquid nitrogen and total RNA was extracted to quantify mRNA expression of HBD-1, HBD-2 and HBD-3 using real time quantitative PCR employing the TaqMan Gene Expression Assays (Applied Biosystems). Statistical analyses were performed using z and Mann Whitney tests in SigmaStat Software and the level of significance adopted was of 5%. In relation to demographic and obstetrics data no statistically significant difference concerning maternal ...
Mestre
Weber, Augusto. "Maturação espermática no epidídimo suíno: análise proteômica do espermatozoide e regulação hormonal da expressão de β-defensinas". reponame:Repositório Institucional da UNIVATES, 2016. http://hdl.handle.net/10737/1580.
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A maturação espermática, que ocorre no epidídimo, é etapa essencial para a aquisição de características necessárias a fertilização in vivo. Durante o transito epididimário o espermatozoide sofre uma série de alterações que transformam uma célula imatura, com pouca capacidade fertilizante, em uma célula matura, apto a fertilizar. O conhecimento das proteínas presentes no espermatozoide de suínos obtidos da cauda do epidídimo e a relação de β-defensinas, proteínas relacionadas com imunidade e reprodução, em testículo e epidídimo de suínos imunizados contra o GnRH, pode esclarecer os mecanismos envolvidos na maturação epididimária. O presente trabalho foi subdivido em dois experimentos, sendo o primeiro relacionado com a proteômica do espermatozoide suíno retirado da cauda do epidídimo, com objetivo de identificar e descrever as proteínas, bem como a relação destas proteínas em vias metabólicas. Foram identificadas 1681 proteínas, através da ferramenta MudPIT, sendo realizadas análises de bioinformática para a descrição dos processos biológicos, componentes celulares e função molecular, bem como foram agrupadas as proteínas em mapas metabólicos. A identificação destas 1681 proteínas permite a formação de um banco de dados para posteriores pesquisas aplicadas. O segundo experimento, que trata da expressão das β-defensinas em epidídimo de suínos imunizados contra o GnRH, objetiva compreender a expressão gênica de β-defensinas em modelo animal de depleção androgênica. Os dados obtidos indicam que a expressão das β-defensinas é maior nos animais imunizados contra o GnRH, sugerindo assim que as β-defensinas sejam andrógeno dependentes. Estes resultados podem ser utilizados no desenvolvimento de biotecnologias aplicadas a reprodução animal, auxiliando assim na melhoria dos índices produtivos e reprodutivos.
Sperm maturation, which occurs on epididymis, is essential to the acquisition of needed characteristics for in vivo fertilization. During the epididymal transit, spermatozoa undergo a series of alterations that transform an immature cell with few fertilizing ability, in a mature cell, with fertilization capacity. The knowledge of proteins presents on boar spermatozoa taken from epididymis cauda and the relationship of β-defensins, proteins related to immunity and reproduction, on testis and epididymis of boars immunized against GnRH, can explain the mechanisms involved on epididymal maturation. The present work was subdivided in two experiments, being the first related with proteomics of boar spermatozoa taken from epididymis cauda, which aim to identify and describe the proteins, besides your relationship with metabolic routes. Were identified 1681 proteins, through MudPIT technology, carried out analyzes of biological process, cellular component and molecular function, grouping this proteins in metabolic routes. The identification of 1681 proteins allow a formation of databank for applied future researches. The second experiment, expression of β-defensins in testis and epididymis of boars immunized against GnRH, aim to understand the genic expression of β-defensins in animal model of androgen depletion. This data indicate that expression of β-defensins is higher on immunized boars, suggesting that porcine β-defensins are dependent of androgens. This results can be utilized to development animal reproductive applied biotechnologies, helping to improve productive and reproductive indices.
Böhling, Arne [Verfasser]. "Biophysikalische Untersuchungen an bakteriellen Modellmembranen bezüglich ihrer lateralen Organisation und der Interaktion mit humanen β-Defensinen / Arne Böhling". Kiel : Universitätsbibliothek Kiel, 2008. http://d-nb.info/1019670266/34.
Повний текст джерелаHinrichsen, Kerstin [Verfasser]. "In-vitro- und In-vivo-Untersuchungen zur Bedeutung der β-Defensine 3 und 14 in der kutanen Erregerabwehr der Maus / Kerstin Hinrichsen". Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019811145/34.
Повний текст джерелаNUNES, Maria Julliana Galvão. "Análise da expressão do TNF-α, β-Defensinas 2 e 3 e proteína p16 na mucosa anal de pacientes infectados pelo Papilomavírus humano". Universidade Federal de Pernambuco, 2017. https://repositorio.ufpe.br/handle/123456789/25395.
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FACEPE
A incidência de carcinoma anal e lesões precursoras relacionadas tem aumentado no mundo, em homens e mulheres e a infecção persistente pelo Papilomavírus humano (HPV) desempenha um papel fundamental na carcinogênese anal. Os fatores de risco para o desenvolvimento de câncer anal incluem intercurso anal, múltiplos parceiros e infecção cervical pelo HPV. Desta forma, o objetivo deste estudo foi avaliar a infecção simultânea pelo HPV na mucosa cervical e anal e elucidar a associação entre a expressão local da proteína p16, β-defensina-2 e 3 e TNF-α (fator de necrose tumoral alfa) na mucosa anal e o grau de lesões anais associadas ao HPV. O grupo de estudo foi constituído por mulheres sexualmente ativas, com idade entre 18 e 60 anos. A coleta de células foi realizada a partir da mucosa cervical e anal com escova ginecológica, seguida de exame de colposcopia e anuscopia. O DNA foi extraído de amostras de células anais e cervicais e a PCR convencional foi realizada para detectar presença de HPV (tipos: 6, 16, 18, 31 e 33). A PCR em tempo real foi realizada utilizando primers específicos para a β-defensina 2, 3 e TNF-α. Os fragmentos de biopsia foram submetidos a coloração hematoxilina-eosina de rotina para a avaliação histológica e reação imunohistoquímica utilizando anticorpo anti-p16. Neste estudo, a positividade para p16 foi associada ao grupo com neoplasia, estatisticamente significativo (p = 0,0002) e padrão contínuo foi predominante. Cerca de 75% dos pacientes com neoplasia foram positivos para HPV e p16. Verificou-se alta taxa de infecção por HPV nas mucosas anal (70,52%), cervical (74,73%) e infecção simultânea cervical e anal (54,73%). A infecção simultânea (mucosa anal e cervical) pelo mesmo tipo de HPV foi observada em 17,30% dos pacientes. Entre os tipos de HPV identificados, o genótipo predominante nas amostras anal e cervical foi HPV6 (26,38%) e (19,71%), respectivamente. Nossos resultados também mostraram uma diminuição da expressão de TNF-α em lesões anais de alto grau em comparação com o normal HPV-positivo (p <0,0001), enquanto que os níveis de expressão de β-defensina 3 aumentaram em pacientes de alto grau (p = 0,0009). A aquisição de infecção simultânea anal e cervical pode ocorrer por diferentes meios, mostrando que o canal anal é uma fonte de infecção.
The incidence of anal carcinoma and related precursor lesions have been increasing worldwide for both men and women. The human papillomaviruses (HPVs) play a fundamental role in anal carcinogenesis, through persistent infection. Women with cervical cancer and history anal intercourse have an increased risk of anal cancer. The aim of this study was to evaluate simultaneous HPV infection in cervical and anal mucosa and to elucidate the association between p16 protein, β-defensin-2, 3 and TNF-α (tumor necrosis factor alpha) expression local in the anal mucosa and the degree of HPV-associated anal lesions. Study group was composed of sexually active immunocompetent women. Cells collection was performed from cervical and anal mucosa with a brush, followed by anuscopy and colposcopy exam. DNA was extracted from anal and cervical cell samples and PCR was performed to detect HPV presence (types: 6, 16, 18, 31 and 33). Real-time PCR was performed using specific primers to β-defensin 2, 3 and TNF-α. Biopsy fragments were subjected to routine hematoxylin-eosin staining for the histological assessment and immunohistochemistry reaction using anti-p16 antibody. In our study, positivity for p16 was frequently associated with group with neoplasia, statistically significant (P = 0.0002) and continuous pattern was predominant. About 75% of patients with neoplasia were positive for HPV and p16. A high rate of HPV infection in anal (70.52%), cervical (74.73%) and simultaneous cervical and anal mucosa (54.73%) was found. Simultaneous infection (anal and cervical mucosa) by the same type HPV was observed in 17.30% of the patients. Among all HPV types identified, the predominant genotype in anal and cervical samples was HPV6 (26.38%) and (19.71%), respectively. Our findings also showed a decreased TNF-α expression in high-grade anal lesion compared to normal HPV-positive (p < 0.0001), whereas expression levels of β-defensin 3 were increased in high-grade patients (p = 0.0009). The acquisition of simultaneous infection anal and cervical may occur by different means, showing that the anal canal is also a source of infection.
Krause, Alexander [Verfasser]. "Charakterisierung neuer humaner antimikrobieller Peptide : LEAP-1, LEAP2 und humanes β-Defensin 4 / von Alexander Krause". 2001. http://d-nb.info/964221667/34.
Повний текст джерелаChang, Ya-Wen, та 張雅雯. "Role of β-defensin 2 in advanced glycation end products- induced effects in NRK-49F cells". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/02662455101675995471.
Повний текст джерела高雄醫學大學
生物化學研究所碩士班
94
Advanced glycation end-product (AGE) is important in the pathogenesis of diabetic nephropathy which is characterized by cellular hypertrophy / hyperplasia leading to renal fibrosis. However, the biological effects of AGE on renal cells remain poorly understood. Our previous study suggesting that AGE induces mitogenesis in NRK-49F cells, which may result in interstitial renal fibrosis. To further investigate the mechanism by which AGE induces mitogenesis, NRK-49F cells were treated with AGE for various time periods. We found that AGE induced the β-defensin 2 mRNA expression at 48 hours. β-defensin 2 has been described as antimicrobial peptides which exhibited chemotactic activity to recruit dendric cells and T lymphocytes. In recent years, β-defensin 2 was also reported to have growth factor-like mitogenic effects on different cell types. AGE-induced β-defensin 2 mRNA expression was attenuated by pretreatment of calphostin C (PKC inhibitor)、LY294002 (PI3K inhibitor)、PD98059 (ERK inhibitor)、SB203580 (p38 MAPK inhibitor) and SP600125 (JNK inhibitor). To reveal the involvement of β-defensin 2 in mitogenesis of NRK-49F cells, we examined the effects of β-defensin 2 on cell proliferation and cell cycle progression by [3H]-thymidine incorporation assay and Western blotting, respectively. Interestingly, β-defensin 2 induced cell proliferation and promoted cell cycle progression in NRK-49F cells by increased cyclin E、cyclin D1 and cdk4. Together, these results suggested the possibility that AGE may induce renal fibroblasts mitogenesis through activation of β-defensin 2.
Chen, Tzu-Yu, та 陳姿伃. "Impacts of Salmonella enterica serovar Typhimurium and antibiotics on human β-defensin expression in human intestinal epithelium". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/jfz2n4.
Повний текст джерела國立臺北科技大學
生物科技研究所
100
Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) is an important pathogen which causes morbidity and mortality worldwide. So far, the early immune responses in human intestinal epithelial cells after Salmonella Typhimurium infection are little known. In this study, we have established an in vitro model to observe IL-8、β-defensin 1、2 and 3 gene and protein expression in human intestinal epithelial cells after Salmonella Typhimurium wild-type strain SL1344 or SPI-1 mutant strain △ spaS infection by RT-PCR and ELISA assay . Furthermore, the effect of Ceftriaxone treatment after infection on gene and protein expression of human IL-8、 β-defensin 1、2 and 3 were investigated. Our results shown the mRNA level of IL-8、β-defensin 1、2 and 3 were increased after wild-type strain and mutant strain infection. However, the ability of wild-type strain is higher than mutant strain. The mRNA level of IL-8 after infection was reduced by Ceftriaxone treatment. However, Ceftriaxone did not affect the mRNA expression of β-defensin-1. On the contrary, the mRNA level of β-defensin 2 and 3 were increased. Furthermore, the level of the protein expression affected by Ceftriaxone treatment was not significant. The results of this study indicated that the intestinal cells encounting typhimurium Salmonella infection may increase the antimicrobial gene expression to resist infection, and treatment of Salmonella typhimurium infection with Ceftriaxone may not interfere with this antibacterial mechanism.
Lee, Po-Hui, та 李柏輝. "Delivery of Parathyroid Hormone or Human β-defensin 2 via Gene Therapy Strategy for Treatment of Craniofacial Bone Defects". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/s5x4n5.
Повний текст джерела國立陽明大學
口腔生物研究所
106
Craniofacial bone defects are common dental conditions. It is still challenging clinically to obtain predictable bone regeneration in large or bacteria-contaminated bone defects. The purpose of this study was to explore the effect of novel regenerative strategies, such as tissue engineering and gene therapy, in difficult-to-treat craniofacial bone defects. The first part of the study was focus on treating large size craniofacial bone defects. Gene activated matrix (GAM) is a nonviral gene therapy technique based on the principles of tissue engineering. A GAM is formed by plasmid DNA (pDNA), encoding gene of growth factor, entrapped in resorbable matrix. GAM composed of pDNA containing gene of parathyroid hormone (PTH) and collagen matrix can effectively promote bone regeneration in bone defects of long bones. Demineralized freeze-dried bone allograft (DFDBA) is one of the bone grafts widely used in dentistry. We aimed to explore the bone regenerative effects of PTH-GAM, with collagen matrix or DFDBA/collagen matrix, in the treatment of rat critical-sized calvarial bone defect. Rat calvarial bone defected were implanted with DFDBA/collagen composite scaffold (D/C), PTH-GAM with collagen matrix (PTH-C-GAM), or PTH-GAM with D/C matrix (PTH-D/C-GAM). The defects without implantation were used as control (Sham). New bone formation was evaluated by performing radiography, dual energy X-ray absorptiometry (DEXA), microcomputed tomography (μCT), and histological examination. The results indicated that the new bone formation in the calvarial bone defects, from more to less, was in the order of PTH-D/C-GAM, PTH-C-GAM, D/C, and Sham groups. We concluded that PTH-GAM with collagen matrix can promote bone regeneration in large craniofacial bone defects in rats. Moreover, the change of the collagen matrix with the D/C matrix improves the osteogenic effects of PTH-GAM. The second part of the study was focus on treating bacteria-contaminated large size craniofacial bone defects. Human β-defensin 2 (hBD2), an antimicrobial peptide of innate immune system, possesses excellent antimicrobial activities and rare drug resistance. The application of hBD2 in bone regenerative therapies is still unexplored. We aimed to determine the effects of hBD2 gene-modified bone marrow mesenchymal stem cell (BMSC) in the treatment of Staphylococcus aureus (S.a.)-contaminated calvarial bone defect in rats. The results indicated that BMSC overexpressing hBD2, generated via adenoviral infection method, can reduce the viable S.a. numbers both in vitro and in vivo. We established a bacteria-contaminated rat calvarial bone defect model and found that bacterial contamination severely compromises the bone regenerative effects of BMSCs. Furthermore, the hBD2 gene-modified BMSCs can dramatically reduce the viable S.a. numbers in the bone defects, mitigate the negative effects of bacterial contamination, and effectively promote bone healing. We hope that with advancement of the novel regenerative techniques, as we used in this study, the current difficult-to-treated bone defects in dental clinical practice can be effectively treated in the future.
Alase, Adewonuola A., J. Seltmann, T. Werfel та Miriam Wittmann. "Interleukin-33 modulates the expression of human β-defensin 2 in human primary keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis". 2012. http://hdl.handle.net/10454/7432.
Повний текст джерелаBackground Interleukin (IL)-33 is a member of the IL-1 family and has been implicated in Th2-driven allergic diseases such as atopic dermatitis (AD) and asthma. The principal Th2 cytokine IL-4, found highly expressed in acute allergic eczema, is known to downregulate human β-defensin 2 (hBD2) expression in human keratinocytes and this is associated with superinfection in patients with AD. Objectives To investigate the effect of IL-33 on the expression of hBD2 in human keratinocytes. Methods hBD2 production by stimulated keratinocytes was measured by enzyme-linked immunosorbent assay. Results Our results showed that serum is a very potent inducer of hBD2 and 2·5% human serum was much more potent in inducing hBD2 than 20 ng mL−1 of tumour necrosis factor-α. Interestingly, serum from patients with AD showed an impaired ability to induce hBD2 in normal keratinocytes. IL-33 significantly downregulated serum-induced hBD2. The downregulatory capacity of IL-33 was found to be 1·5- to 2-fold weaker compared with IL-4. Conclusions Our data suggest that IL-33 can significantly contribute to the decreased expression of hBD2 in acute eczematous reaction clinically characterized by spongiosis and oozing – thus indicative for contact of the epidermis with serum components.
"PEPTIDE ENGINEERING FOR DEVELOPMENT OF ANTIMICROBIALS AGAINST Mannheimia haemolytica." Thesis, 2013. http://hdl.handle.net/10388/ETD-2013-10-1332.
Повний текст джерелаJübner, Martin [Verfasser]. "Immunologische und immunhistochemische Charakterisierung des neuen humanen β-Defensins [Beta-Defensins] hBD17 / von Martin Jübner". 2004. http://d-nb.info/97226373X/34.
Повний текст джерелаSaß, Vera [Verfasser]. "Die molekulare Wirkung des humanen β-Defensins [Beta-Defensins] hBD3 auf Staphylococcus aureus / vorgelegt von Vera Saß". 2008. http://d-nb.info/990974677/34.
Повний текст джерелаRodríguez, Jiménez Francisco Javier [Verfasser]. "Identification and characterization of three new human β-defensins [beta-defensins]: hBD23, hBD27, and hBD29 / von Francisco Javier Rodríguez Jiménez". 2003. http://d-nb.info/969277040/34.
Повний текст джерелаMintcheva, Mariana E. [Verfasser]. "Genexpression humaner β-defensine [beta-defensive] (HBD-1, -2), Interleukine(IL-6, -8) und von Cyclooxygenase-2 in odontoblasten-ähnlichen Zellen und Gingivaepithelzellen nach bakterieller Stimulation / Mariana Emilova Mintcheva". 2008. http://d-nb.info/989777871/34.
Повний текст джерелаSchulz-Maronde, Sandra [Verfasser]. "Identifizierung und funktionelle Charakterisierung von hBD3, einem neuen antimikrobiellen Peptid aus der Gruppe der humanen β-Defensine [Beta-Defensine] / von Sandra Schulz-Maronde". 2003. http://d-nb.info/969247044/34.
Повний текст джерелаTrabert, Susanne [Verfasser]. "Vergleichende Untersuchung zur Expression antimikrobieller Peptide (humaner β-Defensine [Beta-Defensine] 1-3) bei der bisphosphonat-assoziierten Knochennekrose und der Osteoradionekrose / vorgelegt von Susanne Trabert". 2010. http://d-nb.info/100204832X/34.
Повний текст джерелаLuley, Kim Barbara [Verfasser]. "Expressionsanalyse von Calprotektin und humanen α- [Alpha-] und β-Defensinen [Beta-Defensinen] in der kolorektalen Karzinogenese / vorgelegt von Kim Barbara Luley". 2005. http://d-nb.info/978695380/34.
Повний текст джерелаPetzl, Nadine [Verfasser]. "Peripartale Expression von Toll-like-Rezeptoren und β-Defensinen [Beta-Defensinen]im Endometrium des Rindes / vorgelegt von Nadine Petzl (geb. Ritter)". 2007. http://d-nb.info/985348151/34.
Повний текст джерелаHsiao, Hsien-Chieh, та 蕭獻謙. "Differential Expression of β-defensins in The Canine Endometrium during Estrus Cycle and with Cystic Endometrial Hyperplasia". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/66520205011373073983.
Повний текст джерела國立嘉義大學
獸醫學系研究所
99
β-defensins (BD) are a family of small cationic proteins that have been shown to be associated in defense against pathogenic organisms. The endometrial epithelium is the first defensive line against pathogenic microbes. To date, the expression of β- defensins in epithelial surfaces have been reported in respiratory tract, gastrointestinal tract, skin, and reproductive tract. However, little is known about β-defensins ex- pression in bitches during estrus cycle and with pyometra. The aim of this study is to extend our knowledge on expression and action of β-defensins in the canine endometrium. We studied canine β-defensins (cBDs) expression between healthy uteri and pyometra samples obtained from bitches presented for ovariohysterectomy. The results of this study demonstrated that the expression of cBD1 were upregulated during pregnancy in uteri under semi-quantitative RT-PCR analysis. And cBD1 expression was markedly increased in hydrometra, mucometra, and pyometra compared with healthy uteri group. The expression of cBD1 upregulated may correlate with abundant glands, thickness in the endometrium. On the other hand, the β-defensins were not regulated by TLR2 and TLR4. In conclusion, the CBDs expression may play an essential role in the innate immune defense of the canine endometrium.
Overgahr, Willebrand Charlotte [Verfasser]. "Die Rolle des humanen β-Defensins-2 [Beta-Defensins-2] in der Regulation der Genexpression von Genen der Immunabwehr in odontoblasten-ähnlichen Zellen / vorgelegt von: Charlotte Overgahr gen. Willebrand". 2007. http://d-nb.info/985185198/34.
Повний текст джерела