Literatura científica selecionada sobre o tema "Yu Zhixue yi shu guan"

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Artigos de revistas sobre o assunto "Yu Zhixue yi shu guan"

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Chen, Pie-Che, Guan-Ling Lin, Hon-Yi Lin, Wan-Hong Huang, Yu-Ming Chuang, Ru-Inn Lin, Shu-Fen Wu, Cheng-Huang Shen e Michael W. Y. Chan. "Abstract 2243: Cyproheptadine exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 2243. http://dx.doi.org/10.1158/1538-7445.am2023-2243.

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Abstract Urothelial carcinoma (UC) is the second most common malignancy of the urinary system with high rate of recurrence, UC patients therefore needed to be treated with surgery followed by chemotherapy. Development of novel therapeutics with minimal side-effect is an urgent issue. Our previous study showed that cyproheptadine (CPH), an anti-histamine, exhibited antitumor activity in UC in vitro and in an xenograft model. In this study, we performed RNA-Seq to examine genes that are differentially expressed after treatment with CPH in UC cells. Our result showed that several genes, including IRF6, were upregulated after treatment with CPH in BFTC905 UC cells. Further experiments found that treatment of CPH could restore the expression of IRF6 in several other UC cell lines, which is due to promoter hypomethylation and enrichment of H3K27 acetylation, as well as H3K4 mono-methylation. Importantly, treatment of CPH can inhibit tumor growth in a syngeneic mouse tumor model. The tumor growth can be further inhibited by combination treatment of CPH and immune checkpoint blockade. Flow cytometric analysis of the tumor found that NK cells are significantly enriched in the CPH treatment group, as compared to DMSO control. Co-culture experiments confirmed that UC cells pretreated with CPH showed an increased NK-92-mediated cytotoxicity. In conclusion, these results suggested that treatment of CPH can inhibit tumor growth, by epigenetic priming of IRF6 in UC. The role of CPH in eliciting anti-tumor innate immune response deserves further investigation. Citation Format: Pie-Che Chen, Guan-Ling Lin, Hon-Yi Lin, Wan-Hong Huang, Yu-Ming Chuang, Ru-Inn Lin, Shu-Fen Wu, Cheng-Huang Shen, Michael W.Y. Chan. Cyproheptadine exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2243.
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Teses / dissertações sobre o assunto "Yu Zhixue yi shu guan"

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Mu, Jian. "Zhuzi de shi li guan ji qi yu li de guan xi zhi yan jiu : yi Zhuzi "Si shu" xue wei zhong xin /". View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202008%20MU.

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Livros sobre o assunto "Yu Zhixue yi shu guan"

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He, Huaishuo. Yi shu yu guan huai. 8a ed. Taibei Shi: Lian jing chu ban shi ye gong si, 1987.

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2

Feng, Zhang. Xing yu yi shu. Guang zhou: Nan fang ri bao chu ban she, 2011.

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3

Fu, Caiwu. Yi shu jiao yu guan li xue. 8a ed. Wuhan Shi: Hubei ren min chu ban she, 2003.

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4

Jie, Shao, ed. Shu fa yu qi ta yi shu de guan xi. Changsha: Hunan mei shu chu ban she, 2008.

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5

Sun, Qimeng. Lian ai guan yu lian ai yi shu. [Beijing: Beijing zhong xian tuo fang ke ji fa zhan you xian gong si, 2012.

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6

Zhou, Yiguan. Zhou Yiguan kou shu: "yi yi guan zhi" de yu wen jiao yu sheng ming guan. Nanning: Guangxi jiao yu chu ban she, 2021.

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7

Zheng, Peiliang. Yi bi yi hua: Guan yu li shu de shu xie zhuang tai. 8a ed. Beijing Shi: Rong bao zhai chu ban she, 2011.

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8

Kong, Fantao. Gong guan kou cai yi shu. 8a ed. Bei jing: Zhong guo shu ji chu ban she, 2000.

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9

Guo, Shaoquan. Tu shu guan guan zhang de su zhi yu guan li yi shu =: Tushuguan guanzhang de suzhi yu guanli yishu. 8a ed. Zhenjiang Shi: Jiangsu da xue chu ban she, 2010.

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10

Chen, Juntao. Wen xue guan nian yu yi shu mei li. 8a ed. Fuzhou: Hai xia wen yi chu ban she, 1986.

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