Teses / dissertações sobre o tema "Tumeurs du cerveau – Enfant"
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Lefevre, Philippe. "Tumeurs cérébrales primitives de l'enfant : expérience du service de cancérologie de Bordeaux". Bordeaux 2, 1994. http://www.theses.fr/1994BOR23088.
Texto completo da fonteSUC, ETIENNE. "Tumeurs cerebrales chez les enfants de moins de trois ans : etude retrospective de 98 cas traites a l'institut gustave roussy". Toulouse 3, 1990. http://www.theses.fr/1990TOU31082.
Texto completo da fonteDE, SURVILLE BRESSAC SANDRINE. "Tumeurs cerebrales chez des enfants irradies pour l. A. L". Nantes, 1993. http://www.theses.fr/1993NANT256M.
Texto completo da fonteOLMOS, GRAZIELLA. "Tumeur et epilepsie : signes revelateurs exclusifs d'une maladie de bourneville : a propos de 2 cas". Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20236.
Texto completo da fonteOgunleke, Abiodun. "Imagerie chimique 3D de tumeurs du cerveau". Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0040/document.
Texto completo da fonteThree-dimensional (3D) histology is a new advanced tool for cancerology. The whole chemical profile and physiological characteristics of a tissue is essential to understand the rationale of pathology development. However, there is no analytical technique, in vivo or histological, that is able to discover such abnormal features and provide a 3D distribution at microscopic resolution.Here, we introduce a unique high- throughput infrared (IR) microscopy method that combines automated image correction and subsequent spectral data analysis for 3D-IR image reconstruction. I performed spectral analysis of a complete organ for a small animal model, a mouse brain with animplanted glioma tumor. The 3D-IR image is reconstructed from 370 consecutive tissue sectionsand corrected using the X-ray tomogram of the organ for an accurate quantitative analysis of thechemical content. A 3D matrix of 89 x 106 IR spectra is generated, allowing us to separate the tumor mass from healthy brain tissues based on various anatomical, chemical, and metabolic parameters. I demonstrate for the first time that quantitative metabolic parameters (glucose, glycogen and lactate) can be extracted and reconstructed in 3D from the IR spectra for the characterization of the brain vs. tumor metabolism (assessing the Warburg effect in tumors). Our method can be further exploited by searching for the whole spectral profile, discriminating different anatomical landmarks in the brain. I demonstrate this by the reconstruction of the corpus callosum and basal ganglia region of the brain
DEBAVELAERE, VINCENT. "Polyamines erythrocytaires et tumeurs cerebrales". Lille 2, 1991. http://www.theses.fr/1991LIL2M048.
Texto completo da fonteRakotomalala-Andrianasolo, Andria. "Développement et caractérisation de modèles cellulaires pour l'étude du rôle de l'oncohistone H3.3 K27M dans le phénotype agressif et la réponse aux thérapies des gliomes pédiatriques diffus de la ligne médiane". Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS015.
Texto completo da fonteH3K27-altered DMG treatment is one of the most significant challenges in pediatric neuro-oncology,with no improvement in patient survival over the past 50 years. In 2012, it was shown that DMGs harbor a specific histone 3 mutation (oncohistone) called H3.3 K27M with a very high prevalence (70-80% of cases). Although theH3.3 K27M impact on the epigenetic landscape has been well described, studies are needed to understand betterits role in DMG cells’ aggressiveness and response to therapies.To study the H3.3 K27M mutation impact on DMG cell phenotypes precisely, we developed andcharacterized pediatric high-grade glioma isogenic cellular models induced and knock-out for the oncohistone.Using these models, we aimed to decipher the oncohistone impact on DMG cell biology and response to anticancertherapies, including radiation therapy, the only current standard of care for DMGs. Characterization of our H3.3 K27M-induced pediatric supratentorial glioma cell lines reveals that the oncohistone affects the response to ionizing radiations and specific targeted therapies in a cellular context-dependentway. Based on these results, we settled to characterize oncohistone biological impacts in a more relevant cellular context of DMG. In that sense, we established H3.3 K27M knock-out cellular models and characterized them regarding their parental DMG H3.3 K27M mutated cell lines. Through omic (transcriptomic and proteomic)and cell metabolism characterizations of these models, we notably showed the H3.3 K27M mutation impact on DMG cells’ lipid metabolism. In 3D spheroid models, this H3.3 K27M-induced lipid metabolism rewiring appeared conditioned by microenvironment factors still under investigation.On the other hand, a functional pharmacological screen identified H3.3 K27M-driven dependencies tospecific DNA repair pathways. In addition, ongoing radiobiological characterization of our models indicates anH3.3 K27M-associated radiosensitivity correlating with a decrease in DNA repair efficiency following ionizingradiations. Beyond this DNA repair impact, our pharmacological screen also revealed an H3.3 K27M-relatedsensitivity to cardiac glycoside drugs. This result makes sense with our transcriptomic data showing enrichmentin genes involved in cardiomyopathies and ion homeostasis among differentially expressed genes with theoncohistone. In this context, we began unraveling the molecular and biological processes underlying thisH3.3 K27M-driven effect.Finally, we used our isogenic cellular models to show that the H3.3 K27M oncohistone drives lipidmetabolism modifications. These metabolic changes could prime H3K27-altered DMG cells to specific regulatedcell death pathways (e.g., ferroptosis) and affect the response to certain therapies. Moreover, the H3.3 K27Mseems to drive specific sensitivities, notably to radiation therapy and cardiac glycoside drugs. Understanding the underlying molecular mechanisms governing these H3.3 K27M-associated Achille heels could highlight newinsights into the oncohistone role in DMG cells and provide rationales for developing new therapeutic strategies
DUFONT, PHILIPPE, e BIQUILLON CATHERINE CARIN. "La neurocysticercose chez l'enfant". Lille 2, 1989. http://www.theses.fr/1989LIL2M117.
Texto completo da fonteFavier, Olivier. "Le medullobastome de l'enfant : etude retrospective sur une serie de 79 cas". Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX20154.
Texto completo da fonteVEINANTE, ROCHE MARTINE. "Les tumeurs cardiaques de l'enfant". Besançon, 1994. http://www.theses.fr/1994BESA3050.
Texto completo da fonteDESENCLOS, CHRISTINE. "Les tumeurs du troisieme ventricule : 24 observations". Lille 2, 1993. http://www.theses.fr/1993LIL2M237.
Texto completo da fonteJackel, Véronique. "Les tumeurs intracardiaques bénignes chez l'enfant". Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M056.
Texto completo da fonteBourgeat-Faure, Delphine. "Choriocarcinome gestationnel avec enfant vivant à terme". Saint-Etienne, 1995. http://www.theses.fr/1995STET6213.
Texto completo da fonteLARRIEU, ELISABETH. "Tumeurs cerebrales primaires multiples d'histologie differente : a propos d'une observation (considerations etiologiques)". Bordeaux 2, 1988. http://www.theses.fr/1988BOR25048.
Texto completo da fonteDONAZZAN, ANTOINE. "Les astrocytomes pilocytiques de la region du troisieme ventricule chez l'enfant". Lille 2, 1989. http://www.theses.fr/1989LIL2M417.
Texto completo da fonteHLADKY, JEAN-PIERRE. "Les malformations arterioveineuses cerebrales de l'enfant : a propos de 93 observations". Lille 2, 1991. http://www.theses.fr/1991LIL2M215.
Texto completo da fonteBonnenfant, Mézeray Valérie. "Les tumeurs cerebrales a revelation antenatale : experience nanceienne et revue de la litterature". Nancy 1, 1993. http://www.theses.fr/1993NAN11199.
Texto completo da fonteDIAZ, JUAN. "Tumeurs cerebrales a expression psychiatrique : a propos d'un cas de meningiome temporal". Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR1M042.
Texto completo da fonteKhotanlou, Hassan. "Segmentation 3D de tumeurs et de structures internes du cerveau en IRM". Phd thesis, Télécom ParisTech, 2008. http://pastel.archives-ouvertes.fr/pastel-00003662.
Texto completo da fonteCHEVALIER, GAULTIER NATHALIE. "Evolution du traitement des tumeurs germinales malignes cerebrales : a propos de 12 observations". Lille 2, 1988. http://www.theses.fr/1988LIL2M120.
Texto completo da fonteMoulié, Nadine. "Adénome parathyroi͏̈dien de l'enfant : à propos d'un cas". Bordeaux 2, 1993. http://www.theses.fr/1993BOR23035.
Texto completo da fonteGUISLAIN, HERAULT VERONIQUE. "Les tumeurs thalamiques dans la maladie de recklinghausen chez l'enfant". Lille 2, 1989. http://www.theses.fr/1989LIL2M171.
Texto completo da fontePRUVO, VERONIQUE. "Les abces cerebraux compliquant des caries chez l'enfant". Lille 2, 1994. http://www.theses.fr/1994LIL2M312.
Texto completo da fonteDAVROUX, CHRISTINE, e OLIVIER GUINARD. "Les tumeurs germinales cerebrales malignes secretant de l'alpha foetoproteine : approche diagnostique et therapeutique actuelle". Lille 2, 1993. http://www.theses.fr/1993LIL2M022.
Texto completo da fonteBOUCHAT, SERGE. "Les tumeurs cardiaques de l'enfant : a propos de trois observations, revue de la litterature". Nice, 1990. http://www.theses.fr/1990NICE6525.
Texto completo da fonteCODDE, MONGES ELISABETH. "Tumeurs malignes de la vessie chez l'enfant : a propos d'un cas de carcinome urothelial". Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20390.
Texto completo da fonteGERVESY, GILLES. "Ponction percutanee des tumeurs cerebrales sous guidage scanner : a propos de 86 observations". Lyon 1, 1991. http://www.theses.fr/1991LYO1M360.
Texto completo da fonteJost, Jean-Brice. "Tumeurs cérébrales non rehaussées en TDM et IRM : aspects diagnostiques et évolutifs". Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR1M176.
Texto completo da fonteToussaint, Manuel. "Les tumeurs vasculaires de la glande parotide chez l'enfant : a propos de 9 observations". Lille 2, 1992. http://www.theses.fr/1992LIL2M059.
Texto completo da fonteBAUBILLIER, ERIC. "Effets de la ketamine sur la circulation cerebrale en anesthesie pediatrique : etude par doppler pulse transcranien". Angers, 1990. http://www.theses.fr/1990ANGE1060.
Texto completo da fonteMallol, Nathalie Clavel Jacqueline. "Caractéristiques périnatales et risques de tumeur maligne du système nerveux central de l'enfant". [S.l.] : [s.n.], 2006. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2006_MALLOL_NATHALIE.pdf.
Texto completo da fonteDAY, SERGE. "Tumeurs carcinoides bronchopulmonaires d'evolution maligne : discussion a partir d'un cas pediatrique". Rennes 1, 1993. http://www.theses.fr/1993REN1M049.
Texto completo da fontePondarré, Corinne. "Topoisomerase 1 : une nouvelle cible pour le traitement des tumeurs primitives neuroectodermiques de l'enfant". Lyon 1, 1994. http://www.theses.fr/1994LYO1M202.
Texto completo da fonteCANNONI, ZATTARA HELENE. "Apport de la cytogenetique et de l'hybridation in situ (fish) au pronostic des tumeurs cerebrales". Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20907.
Texto completo da fonteZAHAF, NAOUFEL. "Place de la radiotherapie dans le traitement des tumeurs cerebrales : a propos de 32 cas traites dans le centre hospitalier de rodez". Toulouse 3, 1988. http://www.theses.fr/1988TOU31192.
Texto completo da fonteTanter, Mickael. "Application du retournement temporel à l'hyperthermie ultrasonore du cerveau". Paris 7, 1999. https://pastel.archives-ouvertes.fr/pastel-00650031.
Texto completo da fontePECHALAT, PHILIPPE. "Le risque de neoplasme transmis a partir d'organes transplantes : aspect particulier des tumeurs cerebrales : a propos de quatre dossiers cliniques". Lyon 1, 1988. http://www.theses.fr/1988LYO1M365.
Texto completo da fonteBUSSET, ROLLAND CORINNE. "Tumeurs malignes primitives du cavum de l'enfant et l'adolescent : a propos de cinq cas". Nantes, 1992. http://www.theses.fr/1992NANT070M.
Texto completo da fonteVASSEL, CHRISTINE. "Effets de l'irradiation cranienne sur la croissance et l'axe somatotrope : etude comparative avant la puberte avec des enfants non irradies". Lille 2, 1994. http://www.theses.fr/1994LIL2M336.
Texto completo da fonteBENOUR, SALIMA. "Les tumeurs virilisantes de l'ovaire : a propos d'un cas d'androblastome chez une fille de 14 ans". Lyon 1, 1994. http://www.theses.fr/1994LYO1M119.
Texto completo da fonteChateil, Jean-François. "Tumeurs et pseudo-tumeurs bénignes du rachis au cours des deux premières décades de la vie : approche diagnostique". Bordeaux 2, 1987. http://www.theses.fr/1987BOR25092.
Texto completo da fonteSERAMONDI, REGIS, e FREDERIC DUCARNE. "Les tumeurs de la region epiphysaire chez l'enfant : apport de la stereotaxie au diagnostic et au traitement". Lille 2, 1991. http://www.theses.fr/1991LIL2M225.
Texto completo da fontePiel, Clément. "Tumeurs du système nerveux central et expositions agricoles aux pesticides". Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0466/document.
Texto completo da fonteIn the international literature, agricultural exposures to pesticides have been put forward as a key hypothesis to explain the excess of brain tumours observed in farmers. The aim of this thesis, based on data from the Agrican cohort, was to investigate the role of agricultural exposures to pesticides in the incidence of the main histological types of central nervous system tumours. With more than 180,000 participants followed since 2005, the Agrican cohort is one of the largest studies on health in agriculture. Internal comparisons adjusted for the main important confounders showed increases in risk among farmers, more pronounced risk among pesticide users, and with strong variations according to the types of crop and livestock farming. Following these initial analyses, work identified carbamate pesticides as a priority to study in relation to brain tumours. Next, further development of the Pestimat served to reconstitute the history of carbamate uses since 1950 in the main French agricultural contexts. After these intermediate steps, survival analyses conducted among Agrican participants showed increased risks of glioma and meningioma in farmers exposed to (dithio/thio)-carbamates, particularly with those recommended for use on vineyards, fruits, potatoes and beets. These findings reinforce the evidence of carcinogenicity among pesticides already suspected for other cancers, and draw attention to other active ingredients, less documented in the literature but relatively homogeneous in terms of chemical structures. Therefore, on the basis of these conclusions and with a public health objective in mind, it seems essential to pursue efforts to reduce farmers' exposure to pesticides
Levrier, Olivier. "Aspects en imagerie par resonance magnetique des tumeurs supratentorielles de la ligne mediane chez l'adulte". Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20834.
Texto completo da fonteAlric, Matthieu. "Conception et modélisation modulaire d'un robot bio-inspiré extensible pour l'accès aux tumeurs dans le cerveau". Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2009. http://tel.archives-ouvertes.fr/tel-00724718.
Texto completo da fonteKucharczak, Jérôme. "Neuropeptides et migration cellulaire : une étude du transcriptome dans les cellules tumorales de côlon et de cerveau". Montpellier 1, 2001. http://www.theses.fr/2001MON13504.
Texto completo da fonteBertazzon, Françoise Beylerian. "Le craniopharyngiome de l'enfant et ses suites prolongées". Montpellier 1, 1989. http://www.theses.fr/1989MON11103.
Texto completo da fonteMonteil, Pascal. "Modifications de la semeiologie clinique des tumeurs cérébrales sus-tentorielles depuis l'introduction de la tomodensitométrie". Bordeaux 2, 1990. http://www.theses.fr/1990BOR23035.
Texto completo da fonteLiégeois, Frédérique. "Coordinations interhémisphériques et développement des capacités cognitives chez le jeune enfant". Aix-Marseille 1, 1998. http://www.theses.fr/1998AIX11068.
Texto completo da fontePlas, Martine. "A propos d'un cas de corticosurrénalome malin découvert à partir d'une hypersomnie : observation-revue de la littérature-discussion". Montpellier 1, 1991. http://www.theses.fr/1991MON11140.
Texto completo da fonte