Literatura científica selecionada sobre o tema "Transition mitose"
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Artigos de revistas sobre o assunto "Transition mitose"
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Trinkaus, J. P. "The midblastula transition, the YSL transition and the onset of gastrulation in Fundulus". Development 116, Supplement (1 de abril de 1992): 75–80. http://dx.doi.org/10.1242/dev.116.supplement.75.
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The first signs of cell motility appear in Fundulus toward the end of cleavage, after cleavages 11 and 12. When blastomeres cease cleaving, their surfaces undulate and form blebs. At first, these blebbing cells remain in place. Gradually thereafter they begin movement, with blebs and fllolamellipodia serving as organs of locomotion. Non-motile cleaving blastomeres have thus differentiated into motile blastula cells. This transformation corresponds to the midblastula transition of amphibian embryos. Gastrulation in Fundulus begins with vegetalward contraction of the external yolk syncytial layer. This causes narrowing of the E- YSL and initiates the epibolic expansion of the blastoderm. Convergent movements of deep cells within the blastoderm begin toward the end of this contraction. The YSL forms as a result of invasion of the yolk cell cytoplasm by nuclei from open marginal blastomeres during cleavage. These YSL nuclei then undergo five metachronous divisions. After this, they divide no more. YSL contraction begins approximately 1.5 hours after cessation of these divisions (21–22°C). This cessation of nuclear divisions is preceded by a gradual decrease in rate. (1) The duration of each succeeding mitosis increases steadily and often some nuclei do not divide at mitosis V. (2) The duration of interphases between succeeding mitoses also increases, but to a much greater degree, and the longest interphase by far is the last one, I-FV, between mitoses FV and V. (3) The mitotic waves responsible for mitosis V move much more slowly than those for the first four mitoses and invariably decelerate. This gradual cessation of YSL nuclear divisions clearly sets the stage for the contraction of YSL cytoplasm and thus the beginning of gastrulation. We call this the YSL transition. It is not to be confused with the midblastula transition, which occurs 3–4 hours earlier. The MBT commences cytodifferentiation; the YSL transition commences morphogenesis.
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del-Pino-Díaz, David. "Juan Carlos I como Piloto de la Transición Española en la Serie "Cuéntame cómo Pasó"." Anduli, n.º 25 (2024): 45–70. http://dx.doi.org/10.12795/anduli.2024.i25.03.
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La pregunta de investigación es el papel de las narrativas audiovisuales en la construcción de mitos para trascender acontecimientos históricos en el imaginario colectivo. El objetivo es estudiar el caso de la figura del Rey Juan Carlos I en la historia de la transición democrática en España (1975-1982) contada en la serie de televisión “Cuéntame cómo pasó”, emitida desde 2001 y con una audiencia de más de 7 millones de espectadores. La metodología cualitativa utilizada consiste en una revisión bibliográfica de trabajos científicos sobre “Cuéntame”, mitos, construcción de la memoria colectiva e historia reciente de España, y el visionado y análisis de las catorce primeras temporadas de Cuéntame (2001-2013 - 253 episodios) utilizando las categorías metodológicas del modelo actancial de semiótica de Julien Greimas. Los resultados muestran que en la primera temporada de la serie ya se establece la idea de que el rey guiará a los españoles hacia la democracia, pero es en la decimocuarta temporada cuando se cierra el círculo con su papel protagonista en la detención del intento de golpe de Estado militar
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Hime, G., e R. Saint. "Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses of Drosophila". Development 114, n.º 1 (1 de janeiro de 1992): 165–71. http://dx.doi.org/10.1242/dev.114.1.165.
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Mutations at the pebble locus of Drosophila melanogaster result in embryonic lethality. Examination of homozygous mutant embryos at the end of embryogenesis revealed the presence of fewer and larger cells which contained enlarged nuclei. Characterization of the embryonic cell cycles using DAPI, propidium iodide, anti-tubulin and anti-spectrin staining showed that the first thirteen rapid syncytial nuclear divisions proceeded normally in pebble mutant embryos. Following cellularization, the postblastoderm nuclear divisions occurred (mitoses 14, 15 and 16), but cytokinesis was never observed. Multinucleate cells and duplicate mitotic figures were seen within single cells at the time of the cycle 15 mitoses. We conclude that zygotic expression of the pebble gene is required for cytokinesis following cellularization during Drosophila embryogenesis. We postulate that developmental regulation of zygotic transcription of the pebble gene is a consequence of the transition from syncytial to cellular mitoses during cycle 14 of embryogenesis.
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HERNÁNDEZ ROURA, SERGIO ARMANDO. "Hijos de Cthulhutl. Deidades prehispánicas y horror cósmico en H.P. Lovecraft". Brumal. Revista de investigación sobre lo Fantástico 11, n.º 2 (22 de dezembro de 2023): 35–56. http://dx.doi.org/10.5565/rev/brumal.845.
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El objetivo de este artículo es mostrar las implicaciones de la propuesta lovecraftiana de horror cósmico en relación a las ideas que el creador de los “Mitos de Cthulhu” tenía sobre los mexicanos y sus deidades prehispánicas; para ello se hará la revisión de dos cuentos “The Transition of Juan Romero” (1919) y “The Electric Executioner” (1929).
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Kuraś, M., e A. Malinowska. "Influence of 1-p-D-arabinofuranosylcytosine on mitotic activity of apical meristem of onion (Allium cepa L.) roots". Acta Societatis Botanicorum Poloniae 47, n.º 1–2 (2015): 173–87. http://dx.doi.org/10.5586/asbp.1978.015.
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The influence of increasing cytosine arabinoside (ara-C) concentration (50, 100, 300 and 500 μg/ml) on the mitotic activity of the apical meristem of onion adventitious roots was investigated during 24-h incubation in ara-C and postincubation in water. Incubation in ara-C inhibits reversibly mitosis, the degree of inhibition being dependent on the concentration used. 50 μg/ml ara-C causes only a slight and transitional mitotic depression, while 100—500 μg/ml reduces the per cent of mitoses in various degrees after 12-h incubation whereas after 24 h all concentrations (100—500) reduce mitosis to the same level of about 2 per cent (80% inhibition). During postincubation in water there occurs after treatment with 100—500 μg/ml ara-C, a wave of highly synchronized mitoses with a peak after 12 h. The highest frequency of synchronized mitoses (60°/o) appeared in roots treated with 300 μg/ml ara-C. The main wave is preceded by a small one with a peak after 2-4 h of postincubation. This seems to be the consequence of phases S and G<sub>2</sub> inhibition by ara-C. It was found that under the influence of ara-C the per cent of mitoses with chromosome aberration and of cells with micronuclei increased only slightly.
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Bernard, Pascal, Kevin Hardwick e Jean-Paul Javerzat. "Fission Yeast Bub1 Is a Mitotic Centromere Protein Essential for the Spindle Checkpoint and the Preservation of Correct Ploidy through Mitosis". Journal of Cell Biology 143, n.º 7 (28 de dezembro de 1998): 1775–87. http://dx.doi.org/10.1083/jcb.143.7.1775.
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The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle. We investigated the role of the fission yeast bub1 gene in spindle checkpoint function and in unperturbed mitoses. We find that bub1+ is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. We show that Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. Such genomic instability is even more dramatic in Δbub1 diploids, leading to massive chromosome missegregation events and loss of the diploid state, demonstrating that bub1+ function is essential to maintain correct ploidy through mitosis. As in larger eukaryotes, Bub1 is recruited to kinetochores during the early stages of mitosis. However, unlike its vertebrate counterpart, a pool of Bub1 remains centromere-associated at metaphase and even until telophase. We discuss the possibility of a role for the Bub1 kinase after the metaphase–anaphase transition.
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Solnica-Krezel, L., T. G. Burland e W. F. Dove. "Variable pathways for developmental changes of mitosis and cytokinesis in Physarum polycephalum." Journal of Cell Biology 113, n.º 3 (1 de maio de 1991): 591–604. http://dx.doi.org/10.1083/jcb.113.3.591.
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The development of a uninucleate ameba into a multinucleate, syncytial plasmodium in myxomycetes involves a change from the open, astral mitosis of the ameba to the intranuclear, anastral mitosis of the plasmodium, and the omission of cytokinesis from the cell cycle. We describe immunofluorescence microscopic studies of the amebal-plasmodial transition (APT) in Physarum polycephalum. We demonstrate that the reorganization of mitotic spindles commences in uninucleate cells after commitment to plasmodium formation, is completed by the binucleate stage, and occurs via different routes in individual developing cells. Most uninucleate developing cells formed mitotic spindles characteristic either of amebae or of plasmodia. However, chimeric mitotic figures exhibiting features of both amebal and plasmodial mitoses, and a novel star microtubular array were also observed. The loss of the ameba-specific alpha 3-tubulin and the accumulation of the plasmodium-specific beta 2-tubulin isotypes during development were not sufficient to explain the changes in the organization of mitotic spindles. The majority of uninucleate developing cells undergoing astral mitoses (amebal and chimeric) exhibited cytokinetic furrows, whereas cells with the anastral plasmodial mitosis exhibited no furrows. Thus, the transition from astral to anastral mitosis during the APT could be sufficient for the omission of cytokinesis from the cell cycle. However, astral mitosis may not ensure cytokinesis: some cells undergoing amebal or chimeric mitosis contained unilateral cytokinetic furrows or no furrow at all. These cells would, most probably, fail to divide. We suggest that a uninucleate committed cell undergoing amebal or chimeric mitosis can either divide or else form a binucleate cell. In contrast, a uninucleate cell with a mitotic spindle of the plasmodial type gives rise only to a binucleate cells. Further, the decision to enter mitosis after commitment to the APT is independent of the developmental changes in the organization of the mitotic spindle and cytokinesis.
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Lu Lu, Tianlong Yun, Li Li, Yuelong Su e Danya Yao. "A Comparison of Phase Transitions Produced by PARAMICS, TransModeler, and VISSIM". IEEE Intelligent Transportation Systems Magazine 2, n.º 3 (2010): 19–24. http://dx.doi.org/10.1109/mits.2010.939193.
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Warecki, Brandt, e William Sullivan. "The Cell Biology of Heterochromatin". Cells 11, n.º 7 (6 de abril de 2022): 1247. http://dx.doi.org/10.3390/cells11071247.
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A conserved feature of virtually all higher eukaryotes is that the centromeres are embedded in heterochromatin. Here we provide evidence that this tight association between pericentric heterochromatin and the centromere is essential for proper metaphase exit and progression into telophase. Analysis of chromosome rearrangements that separate pericentric heterochromatin and centromeres indicates that they must remain associated in order to balance Cohesin/DNA catenation-based binding forces and centromere-based pulling forces during the metaphase–anaphase transition. In addition, a centromere embedded in heterochromatin facilitates nuclear envelope assembly around the entire complement of segregating chromosomes. Because the nuclear envelope initially forms on pericentric heterochromatin, nuclear envelope formation proceeds from the pole, thus providing time for incorporation of lagging and trailing chromosome arms into the newly formed nucleus. Additional analysis of noncanonical mitoses provides further insights into the functional significance of the tight association between heterochromatin and centromeres.
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Mehsen, Haytham, Vincent Boudreau, Damien Garrido, Mohammed Bourouh, Myreille Larouche, Paul S. Maddox, Andrew Swan e Vincent Archambault. "PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila". Journal of Cell Biology 217, n.º 12 (11 de outubro de 2018): 4106–23. http://dx.doi.org/10.1083/jcb.201804018.
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As a dividing cell exits mitosis and daughter cells enter interphase, many proteins must be dephosphorylated. The protein phosphatase 2A (PP2A) with its B55 regulatory subunit plays a crucial role in this transition, but the identity of its substrates and how their dephosphorylation promotes mitotic exit are largely unknown. We conducted a maternal-effect screen in Drosophila melanogaster to identify genes that function with PP2A-B55/Tws in the cell cycle. We found that eggs that receive reduced levels of Tws and of components of the nuclear envelope (NE) often fail development, concomitant with NE defects following meiosis and in syncytial mitoses. Our mechanistic studies using Drosophila cells indicate that PP2A-Tws promotes nuclear envelope reformation (NER) during mitotic exit by dephosphorylating BAF and suggests that PP2A-Tws targets additional NE components, including Lamin and Nup107. This work establishes Drosophila as a powerful model to further dissect the molecular mechanisms of NER and suggests additional roles of PP2A-Tws in the completion of meiosis and mitosis.
Teses / dissertações sobre o assunto "Transition mitose"
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Detti, Mélanie. "Méthylation des adénosines (m6A) des ARN dans les cellules germinales et infertilité". Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6044.
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La différenciation sexuelle est un mécanisme complexe, où une gonade indifférenciée, va se développer en testicule chez les mâles ou en ovaire chez les femelles. Le sexe chromosomique est à l'origine de la détermination sexuelle, en activant des voies de signalisation sexe-spécifique. Découvert en 1990, le gène SRY, présent sur le chromosome Y des mâles, est un gène qui a longtemps été décrit comme le régisseur de toute la différenciation sexuelle. En sa présence, les embryons XY se différencient en mâles, mais son absence est suffisante pour induire la différenciation femelle, « par défaut ». Or, la détermination du sexe est bien plus complexe, impliquant l'expression de nombreux gènes, dont les niveaux d'expression équilibrés activent la voie ovarienne et répriment simultanément la voie testiculaire ou vice versa. Le développement d'un ovaire ou d'un testicule repose sur la présence des cellules somatiques ainsi que des cellules germinales, les seules cellules capables de réaliser la méiose.La méiose, découvert en 1883, est également un événement dépendant de la détermination du sexe, étant donné qu'elle se produit pendant le développement embryonnaire chez la femelle, et en post-natal chez les mâles. Encore une fois, de nombreux gènes doivent être finement régulés pour l'initiation et le déroulement correct de la méiose. En effet, les cellules germinales prolifèrent activement, puis doivent perdre leur pluripotence et entrer en méiose chez les femelles, tandis qu'elles restent pluripotentes et rentrent en quiescence chez les mâles. Cette transition s'opère par un changement de programme génétique, qui n'est pas encore totalement compris.L'étude des différents acteurs régulant la différenciation sexuelle, autant au niveau somatique que germinale, est alors une priorité de mon équipe, spécialiste du développement gonadique embryonnaire.La méthylation en position 6 de l'adénine des molécules d'adénosine de l'ARN (m6A) est un mécanisme émergent et encore peu compris de la régulation de l'expression des gènes. Pourtant elle est la modification de l'ARN la plus courante et la plus conservée chez les eucaryotes, et son importance est soulignée par différentes pathologies résultant des dysfonctionnements de cette méthylation. A l'heure actuelle, elle est connue pour réguler des processus très variés comme des processus de métaboliques, de développement, de différenciation cellulaire ou de réponse au stress.C'est alors que nous avons décidé d'étudier le rôle de Wtap, un acteur du complexe de méthylation m6A, dans la détermination du sexe et la méiose. Mes recherches ont permis de comprendre dans un premier temps que Wtap est bien exprimé dans les différents types cellulaire de la gonade, et ce, pendant la fenêtre critique de la différenciation sexuelle. Dans un second temps, grâce à un modèle murin perte de fonction pour Wtap spécifiquement dans les cellules somatiques, nous avons pu montrer que ce gène est crucial pour la différenciation des cellules somatiques mâles et femelles. En effet, les cellules de Sertoli et de la granulosa semblent pour la majeure partie, bloquées dans un stade pré-cellules de soutient. Enfin, dans un dernier temps, cette fois ci avec un modèle murin permettant l'inactivation de Wtap dans les cellules germinales uniquement, nous avons également analysé une diminution de leur différenciation. Les cellules germinales ne sont plus totalement en capacité d'induire la méiose chez les femelles, et de rentrer en quiescence chez les mâles.Ces résultats indiquent que Wtap, est un acteur clé pour la régulation de la différenciation des cellules somatiques et germinales, autant chez le mâle que chez la femelleSexual differentiation is a complex mechanism where an undifferentiated gonad develops into a testis in males or an ovary in females. Chromosomal sex is at the origin of sexual determination, by activating sex-specific signaling pathways. Discovered in 1990, the Sry gene, found on the Y chromosome of males, has long been described as the regulator of all sexual differentiation. In its presence, XY embryos differentiate into males, but its absence is sufficient to induce female differentiation, “by default”. However, sex determination is far more complex, involving the expression of numerous genes, whose balanced expression levels activate the ovarian pathway and simultaneously repress the testicular pathway, or vice versa. The development of an ovary or testis relies on the presence of somatic cells as well as germ cells, the only cells capable of meiosis.Meiosis, discovered in 1883, is also a sex-determining event, as it occurs during embryonic development in females, and post-natal in males. Once again, many genes must be finely regulated for meiosis for correct initiation and progressing. Germ cells proliferate actively, then lose their pluripotency and enter meiosis in females, while they remain pluripotent and enter quiescence in males. This transition takes place by a change in the genetic program, which is not yet fully understood.The study of the various actors regulating sexual differentiation, at both somatic and germline levels, is therefore a priority for my team, which specializes in embryonic gonadal development.N6-methyladenosine (m6A) is an emerging and still poorly understood mechanism of gene expression regulation. Yet it is the most common and most conserved RNA modification in eukaryotes, and its importance is underlined by various pathologies resulting from dysfunctions of this methylation. It is currently known to regulate a wide variety of processes, including metabolism, development, cell differentiation and stress response.We therefore decided to investigate the role of Wtap, an actor in the m6A methylation complex, in sex determination and meiosis. Firstly, my research showed that Wtap is well expressed in different gonadal cell types during the critical window of sexual differentiation. Secondly, using a loss-of-function mouse model for Wtap specifically in somatic cells, we were able to show that this gene is crucial for the differentiation of male and female somatic cells. Indeed, most Sertoli and granulosa cells appear to be blocked in a pre-supporting state. Finally, using a mouse model in which Wtap is inactivated in germ cells only, we also analyzed a decrease in germ cell differentiation. Germ cells are no longer fully able to induce meiosis in females, and enter quiescence in males.These results indicate that Wtap is a key player in the regulation of somatic and germ cell differentiation in both males and females
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Buffin, Eulalie. "Régulation de la transition métaphase-anaphase au cours de la mitose chez la drosophile". Paris 6, 2006. http://www.theses.fr/2006PA066241.
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Régulation de la transition Métaphase-Anaphase au cours de la mitose chez la drosophile Le checkpoint de métaphase détecte la présence des kinétochores non attachés et génère un signal inhibiteur de l’anaphase afin de permettre à tous les chromosomes d’établir un attachement bipolaire avec le fuseau. Ce mécanisme fait intervenir les protéines Mad et Bub et un complexe appelé RZZ (Rod-Zw10-Zwilch) qui n’a pas d’homologue chez la levure et qui fait l’objet de ma thèse. L’analyse in vivo chez la drosophile, du comportement des protéines RFP-Rod et GFP-Mad2 dans les neuroblastes larvaires en division, a montré que RZZ et Mad2 sont associées pendant presque toute la mitose et que RZZ est nécessaire pour le recrutement normal de Mad2 sur les kinétochores. En outre, l’étude phénotypique d’un mutant mad2 nul chez la drosophile, qui de façon surprenante pour un mutant du checkpoint, est viable et ne présente pas de défauts mitotiques, a suggéré que Mad2 et le checkpoint de métaphase ne sont pas essentiels pour le déroulement normal de la mitose chez la drosophileLe checkpoint de métaphase détecte la présence des kinétochores non attachés et génère un signal inhibiteur de l’anaphase afin de permettre à tous les chromosomes d’établir un attachement bipolaire avec le fuseau. Ce mécanisme fait intervenir les protéines Mad et Bub et un complexe appelé RZZ (Rod-Zw10-Zwilch) qui n’a pas d’homologue chez la levure et qui fait l’objet de ma thèse. L’analyse in vivo chez la drosophile, du comportement des protéines RFP-Rod et GFP-Mad2 dans les neuroblastes larvaires en division, a montré que RZZ et Mad2 sont associées pendant presque toute la mitose et que RZZ est nécessaire pour le recrutement normal de Mad2 sur les kinétochores. En outre, l’étude phénotypique d’un mutant mad2 nul chez la drosophile, qui de façon surprenante pour un mutant du checkpoint, est viable et ne présente pas de défauts mitotiques, a suggéré que Mad2 et le checkpoint de métaphase ne sont pas essentiels pour le déroulement normal de la mitose chez la drosophile
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Bonnet, Jérôme. "Etude de la fonction de la phosphatase Cdc25C a la transition G2/M". Montpellier 2, 2007. http://www.theses.fr/2007MON20129.
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Xu, Naihan. "Regulation of the metaphase-anaphase transition in mitosis in mammalian cells /". View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20XU.
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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.Includes bibliographical references (leaves 242-266). Also available in electronic version. Access restricted to campus users.
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BERTINI, EFREM. "Yap is regulated by phosphorylation at the G2/M transition". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1192.
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La proteina umana Yap è un co-fattore trascrizionale ed è stata di recente oggetto di molti studi per la sua capacità di interagire con molti fattori di trascrizione. Questa capacità ha condotto molti ricercatori a fornire diverse interpretazioni sulla sua funzione, descrivendola sia come una proteina con attività onco-soppressiva, e sia come un fattore oncogenico. Inoltre, recenti studi hanno indicato un suo ruolo nella differenziazione cellulare e nella regolazione della dimensione di organi, in particolare del fegato. Tuttavia, il ruolo di questa proteina nella regolazione del ciclo cellulare è rimasto finora elusivo. Con il lavoro svolto durante il periodo di dottorato e riportato di seguito, mostriamo che Yap viene fosforilata in mitosi e forniamo alcune indicazioni su un suo possibile ruolo in questa fase del ciclo. In particolare, abbiamo notato che la proteina viene de-fosforilata prima dell’uscita dalla mitosi suggerendo un suo ruolo come co-fattore nella trascrizione nell’imminente nuovo ciclo cellulare, e abbiamo quindi fornito le basi per un indagine più approfondita di tale evento.Yap is a small protein that acts as a co-activator of transcription. It has been shown to interact with many and diverse transcription factors and as a result of these promiscuous interactions, Yap has been described to have a role in many cellular events, including apoptosis, proliferation, and differentiation. For this reason, it is described to have a role both in tumor suppression and transformation. However, the function of Yap in the regulation of the cell cycle has not been investigated so far. Here we demonstrate that Yap is phosphorylated at the G2/M, both in physiologic mitotic cells and in cells arrested in mitosis by microtubules-targeting drugs. We show that Yap is not recruited onto the chromatin during mitosis and does not localize to any mitotic organelles. In addition, we have noticed that de-phosphorylation of Yap occurs before the entry into G1. These data give an indication that Yap may have a role in the exit from mitosis, and place a solid foundation for characterizing the function(s) of Yap during this event.
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Soni, Deena. "Studies on regulation of mitotic transition by cyclin B1/CDK1". Connect to text online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1099070698.
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Thesis (Ph. D.)--Case Western Reserve University, 2005.[School of Medicine] Department of Environmental Health Sciences. Includes bibliographical references. Available online via OhioLINK's ETD Center.
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Soni, Deena V. "Studies on the regulation of mitotic transition by cyclin B1/Cdk1". Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1099070698.
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Hazra, Ditipriya. "Insights into the control of mRNA decay by YTH proteins during the transition from meiosis to mitosis in yeasts". Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX041.
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Aperçu du contrôle de la dégradation des ARNm par les protéines YTHpendant la transition de la méiose à la mitose chez les levures.Le cycle cellulaire est contrôlé par des processus complexes et interconnectés. Un gène est transcrit en ARNm qui est traduit en protéines mais de nombreux processus de régulation travaillent pour contrôler chaque étape de ce processus apparemment simple. Parmi ces points de contrôle, la régulation post-transcriptionnelle est importante, et la formation d'un complexe protéine-ARN peut diriger le destin cellulaire. Parmi ces protéines de liaison à l'ARN, les protéines contenant des domaines YTH n’ont été découvertes qu’à la fin des années 90. Les protéines contenant des domaines YTH sont abondantes chez les eucaryotes et absentes chez les procaryotes. Elles constituent la majorité des protéines « readers » capables de reconnaître spécifiquement la modification m6A. L’Homme possède cinq protéines YTH, YTHDF1-3, YTHDC1,2 (Hazra, D., C. Chapat, et Graille, M. (2019). Destin de l'ARNm de m6A : enchaînés au rythme par les protéines contenant de la YTH. , 10 (1), 49.). Bien qu'il soit évident que ces protéines contrôlent le destin cellulaire, la fonction de chaque protéine et son réseau d’interaction restent à élucider. Chez les levures, une seule protéine YTH est présente: Pho92 chez Saccharomyces cerevisiae et Mmi1 chez Schizosaccharomyces pombe. Hormis le domaine YTH, il n'y a pas d'homologie de séquence entre ces deux protéines mais leur fonction cellulaire est similaire.Il est bien établi que Mmi1 est responsable de la dégradation des transcrits spécifiques de la méiose au cours de la croissance végétative des cellules chez la levure S. pombe. Mmi1 forme un complexe stable avec une petite protéine, Erh1 (complexe Erh1-Mmi1 ou EMC). Le complexe EMC peut physiquement interagir avec la sous-unité Not1 du complexe CCR4-Not et la recruter pour la dégradation des ARNm contenant des motifs DSR (déterminant de l'élimination sélective). L'action de Mmi1 est à son tour régulée par une protéine possédant un domaine RRM, Mei2. Au cours de la méiose, Mei2, avec l’aide d’un lncRNA meiRNA, séquestre Mmi1 dans un point nucléaire, le rendant inactif et assurant la continuité de la méiose. Ces trois protéines, Mmi1-Erh1-Mei2, jouent un rôle clé dans la transition de la mitose vers la méiose.Chez S. cerevisiae, Pho92 est impliquée dans la dégradation des transcrits de PHO4, contribuant à la voie du métabolisme du phosphate, pendant la privation en phosphate et participe également à la dégradation des ARNm contenant les marques épitranscriptomiques de N6-méthyladénosine (m6A). Comme pour S. pombe Mmi1, Pho92 recrute le complexe CCR4-Not via une interaction physique avec Not1.Au cours de ma thèse, j'ai tenté d'élucider le rôle de ces deux protéines du domaine YTH de deux organismes modèles, S. cerevisiae et S. pombe, dans la dégradation de l'ARNm et la régulation du cycle cellulaire par des approches biochimiques et structurales.Pho92 de S. cerevisiae interagit physiquement avec Not1 du complexe CCR4-Not, nous avons pu déterminer les limites des domaines impliqués dans cette interaction. L’interaction entre ces deux protéines a été étudiée par anisotropie de fluorescence. Le complexe protéique a été purifié avec succès et des essais de cristallisation sont en cours.Chez S. pombe, la structure de Mei2-RRM3 a été résolue avec et sans ARN. Les propriétés de liaison à l'ARN de Mei2-RRM3 ont été étudiées par ITC. La structure de Erh1 a également été résolue révélant une organisation en homodimere. Nous avons montré que la formation de cet homodimere est important pour la fonction biologique de Mmi1. Des essais de co-cristallisation ont été réalisés avec de l'ARN et les protéines Mmi1 et Mei2, mais sans succès et nous avons obtenu des cristaux de Mmi1Insights into the control of mRNA decay by YTH proteinsduring the transition from meiosis to mitosis in yeasts.Keywords: Epitranscriptomics, mRNA decay, meiosis, multi-protein complexes, YTH domainCell cycle is controlled by multi-layered processes. A gene is transcribed in mRNA which is translated in proteins but innumerable regulation processes are working to control every step of this apparently simple process. Among these regulatory check points, post-transcriptional regulation is an important one, where formation of a protein-RNA complex may direct the cellular fate. Among these RNA binding proteins, YTH domain proteins are most novel, discovered in late 90s. YTH domain proteins are abundant in eukaryotes and absent in prokaryotes. YTH domain proteins constitute the majority of reader proteins that can specifically identify m6A modification. Human beings have five YTH domain proteins YTHDF1-3, YTHDC1-2 (Hazra, D., Chapat, C., & Graille, M. (2019). m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins. Genes, 10(1), 49.). Although it is evident that these proteins are controlling cellular fate, the function of each protein and their network is yet to be elucidated. In yeast, there is only one YTH domain protein present: Pho92 in Saccharomyces cerevisiae and Mmi1 in Schizosaccharomyces pombe. Apart from the YTH domain there is no sequence homology between these two proteins but their cellular function is similar.It is well established that Mmi1 is responsible for degradation of meiosis specific transcripts during vegetative growth of the cell. Mmi1 forms a tight complex with a small protein, Erh1 (Erh1-Mmi1 complex or EMC). EMC can physically interact with Not1 of CCR4-Not complex and recruit it for degradation of DSR (determinant of selective removal) containing RNAs. The action of Mmi1 is in turn regulated by an RRM domain protein, Mei2. During meiosis, Mei2, along with a lncRNA meiRNA sequesters Mmi1 in a nuclear dot, rendering it inactive and ensuring smooth continuance of meiosis. These three proteins, Mmi1-Erh1-Mei2 play a key role in mitosis to meiosis switch.In S. cerevisiae, Pho92 is involved in the degradation of PHO4 transcripts contributing to phosphate metabolism pathway, during phosphate starvation and also participates in the degradation of mRNAs containing the N6-methyladenosine (m6A) epitranscriptomics marks. Similarly, to S. pombe Mmi1, Pho92 recruits CCR4-Not complex by physical interaction with Not1.During my PhD, I have tried to elucidate the role of these two YTH domain proteins from two model organisms, S. cerevisiae and S. pombe, in mRNA degradation and cell cycle regulation using biochemical and structural approaches.Pho92 of S. cerevisiae physically interacts with Not1 of CCR4-Not complex, we were able to determine the boundaries of this interaction. The interaction between these two proteins was studied by Fluorescence anisotropy. The protein complex was successfully purified and crystallization trials are ongoing.From S. pombe, structure of Mei2-RRM3 was solved with and without an RNA. RNA binding properties of Mei2-RRM3 was studied by ITC. The structure of Erh1 was also solved and we tried to elucidate its importance for biological function of Mmi1. A co-crystallization trial was performed with Mmi1-Mei2-RNA but it was unsuccessful and we ended up with Mmi1 crystals
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Potapova, Tamara. "Exploring mechanisms that control the activity of cyclin-dependent kinase 1 during mitotic transitions in somatic cells". Oklahoma City : [s.n.], 2009.
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Beaujois, Rémy. "Motifs de régulation et dynamique de la voie Mitogen Activated Protein Kinase lors de la transition G2/M des ovocytes de Xénope". Thesis, Lille 1, 2010. http://www.theses.fr/2010LIL10150/document.
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Lors de la transition G2/M des ovocytes de Xénope, la voie p39Mos-MEK1-MAPK présente des propriétés dynamiques et physiques particulières telles que l’ultrasensibilité, la bistabilité, l’irréversibilité et un caractère ‘tout-ou-rien’. Ces propriétés sont considérées dans le contexte de la boucle de rétroaction positive qui existe au sein de cette voie. L’objectif de cette thèse s’est focalisé sur le rôle de l’oncoprotéine p39Mos et le recrutement des motifs de régulation qui permettent l’apparition de ces propriétés. Des approches expérimentales et in silico ont été menées pour réaliser une modélisation physiquement et biologiquement réaliste de ce réseau. Le modèle développé tient compte de l’influence du MPF sur l’accumulation de p39Mos et ajuste le rôle de la boucle de rétrocontrôle positif. Par ailleurs, nous avons pu mettre en évidence que p90Rsk, cible des MAPK, est dégradée. La voie MAPK a été activée en absence de p39Mos. Nos résultats montrent que la 1,10 Phénanthroline monohydrate (1,10-PA) active les MAPK suivant une réponse graduelle et ultrasensible. L’action de la 1,10-PA s’exerce en absence de synthèse protéique et de toute boucle de rétrocontrôle, et nous avons émis l’hypothèse que la 1,10 PA agit via l’inactivation d’une MEK-phosphatase. Dans ce contexte, un modèle de pro-action est discuté et des inhibiteurs de phosphatases ont été utilisés pour activer les MAPK en absence de p39Mos. Nos résultats discutent du rôle de la boucle de rétroaction positive dans l’activation des MAPK et montrent que l’ultrasensibilité de réponse des MAPK peut être générée par des motifs de régulation de type pro-actionDuring G2/M transition in Xenopus oocyte, p39Mos-MEK1-MAPK cascacade harbors specific dynamic and physical properties, such as ultrasensitivity, bistability, irreversibility, and all-or-none responses. These properties are generally considered in the context of the positive feedback loop that embeds the p39Mos-MEK1-MAPK pathway architecture. The objective of this work was focused onto p39Mos oncoprotein and regulation motifs recruitment enabling together the generation of such properties. Both experimental and in silico approaches were undertaken in order to yield a realistic modelisation, physically and biologically relevant for this network. We developed a model that takes into account the influence of MPF onto p39Mos accumulation, and adjusts the role of the positive feedback loop. Also, we were able to show that p90Rsk, target of MAPK, was degraded. This signaling pathway was activated in the absence of p39Mos. Our results show that 1,10 Phénanthroline monohydrate (1,10-PA) is able to induce gradual and ultrasensitive MAPK activation. 1,10-PA action is then exerted in the absence of protein synthesis and positive feedback loop. In this context, a feed forward loop model can be considered, and phosphatase inhibitors were used for MAPK activation in the absence of p39Mos. Our results confront the role attributed to the positive feedback loop in MAPK activation, and show that this ultrasensitive response may be generated in vivo through feed forward regulation motifs
Capítulos de livros sobre o assunto "Transition mitose"
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Houck, Marilyn A. "Adaptation and Transition into Parasitism from Commensalism: A Phoretic Model". In Mites, 252–81. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2389-5_10.
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Hepler, Peter K. "Calcium Regulation of Mitosis: The Metaphase/Anaphase Transition". In Molecular and Cellular Aspects of Calcium in Plant Development, 167–74. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2177-4_21.
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Courtois, Aurélien, e Takashi Hiiragi. "Gradual Meiosis-To-Mitosis Transition in the Early Mouse Embryo". In Results and Problems in Cell Differentiation, 107–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-30406-4_6.
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Ferrari, S., e G. Thomas. "The Mitogen/Oncogene-Activated p70s6k: Its Role in the G0/G1 Transition". In DNA Replication and the Cell Cycle, 171–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77040-1_13.
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Kaszkin, M., e V. Kinzel. "Role of Phospholipid Metabolites in the Cell Cycle Delay Caused by Epidermal Growth Factor at the Transition from G2-Phase to Mitosis in A431 Cells". In Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, 537–40. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3520-1_105.
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Chamati, Hassan. "Theory of Phase Transitions". In A Tribute to Marin D. Mitov, 237–85. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-411516-3.00009-7.
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Gobin, Bruno, e Joachim Audenaert. "Practical application of integrated pest management in greenhouses and protected cultivation". In Improving integrated pest management in horticulture, 359–86. Burleigh Dodds Science Publishing, 2022. http://dx.doi.org/10.19103/as.2021.0095.14.
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Greenhouse production is at the forefront of using IPM systems to tackle pests and diseases. The shift to IPM was a challenge for growers, but was overcome through research, extension and demonstration of the strengths of biocontrol. We provide examples from ornamental plant greenhouse horticulture with a focus on how: (1) good communication and education of growers is important for facilitating transition to IPM; (2) increased hygiene measures reduced disease pressure and control needs; (3) the success of predatory mites increased confidence in further IPM, especially when adapted to specific greenhouse circumstances; (4) management of broad mite, a difficult and elusive pest, benefited from biological control; (5) adding food to the crop will help establish a standing army of beneficials; and (6) mealy bug control still poses a major challenge, but biocontrol shows promise. We see that the increased use of dynamic spectral lighting, increased automation and multilayer growing will pose future challenges that should be addressed in ongoing research.
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Guanga-Lara, Verónica Elizabeth, e Willian Bayardo Galarza-Esparza. "La nutrición como ciencia". In Antropología Alimentaria, 211–27. Editorial Grupo AEA, 2023. http://dx.doi.org/10.55813/egaea.cl.2022.36.
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El capítulo que hemos tenido el placer de escribir tiene como objetivo contribuir al conocimiento sobre la Nutrición como ciencia partiendo de una perspectiva amplia e integradora, considerando que la nutrición está en constante evolución, integrada por un conjunto de disciplinas científicas que transitan desde las ciencias exactas, hasta las ciencias políticas, mediante la aplicación del método clínico como una modalidad del método científico obliga a considerar a la nutrición también con esta visión y no como la última opción del médico en una intervención diagnóstica o terapéutica, contaminada por mitos, tabúes y prejuicios culturales.
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Alonso, José Antonio, e José Antonio Ocampo. "Economic Traps and Progress in Middle-Income Countries". In Trapped in the Middle?, 1–23. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198852773.003.0001.
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The chapter discusses the existence of potential economic traps that limit the capacity for middle-income countries (MICs) to converge towards high-income status. It presents an empirical exploration of the two interpretations (absolute and relative) of middle-income traps (MITs) and considers transitions between country categories that occurred during the last three decades. Even if transitions are a rare phenomenon, the authors conclude that evidence is not able to settle the existence of MITs, but it is enough to illustrate the severity of the challenges that MICs face in their development path. The chapter analyses the theoretical arguments offered to justify the presence of these pitfalls, as well as the main policy responses required to overcome them. Even if more analytical work is required, the chapter underlines that the debate around MITs has revitalized reflection on the active policies required to promote growth in MICs. Finally, the chapter presents an overview of the book, underlying the main contributions of each chapter.
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Hamer, M. J., J. Hamil Ton, A. White, J. Rosamond e C. M. Bray. "Control of initiation of DNA synthesis in plants". In Protein Phosphorylation in Plants, 211–26. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780198577775.003.0016.
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Abstract A central feature of the control of growth and differentiation in plants concerns the control of both the timing and direction of cell division. Examples of periods during the life cycle of a higher plant at which this control is exhibited include seed development and germination, leaf development in cereals, and floral induction in the shoot apex. Indeed, plant morphogenesis is dependent predominantly upon the spatial and temporal control of cell expansion and division (Doonan 1991). In all eukaryotes, cell division appears to be regulated by p34cctc kinase-cyclin complexes which are activated at the 02/M transition and which trigger the events required for entry into mitosis (Nurse 1990). There appears to be a high degree of conservation of at least some of the components which regulate mitosis amongst eukaryotes and this has allowed the substitution of yeast genes by homologues from distantly related organisms such as Homo sapiens (Lee and Nurse 1989) and plants (Colosanti et al. 1991). The p34cctc homologue for maize has also been demonstrated to be associated with the preprophase band in dividing plant cells and to have a role in establishing the division site in these cells (Colosanti et al. 1993). Although the control mechanisms operative at the G2/M transition have been extensively studied in both yeasts and higher eukaryotes, much less is known about the controls acting at the other major mitotic cell cycle control point, i.e. at the G1/S transition prior to the initiation of DNA synthesis. However, recent evidence from budding yeast suggests that interactions between p3c4ctc and unstable G1 cyclins are an important aspect of that control. Regulation at Gl/S appears to be important in higher plants, particularly in developing seeds where the nuclei of many species are arrested exclusively in the G1 phase of the cell division cycle, indicating a strict control of nuclear events which ensures that all nuclei enter the final developmental and drying phases of maturation at the same stages of their cell cycle (Bewley and Black 1985).
Trabalhos de conferências sobre o assunto "Transition mitose"
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Li, G., S. S. Nair, S. J. Lees e F. W. Booth. "Regulation of G2/M Transition in Mammalian Cells by Oxidative Stress". In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-82349.
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The regulation of the G2/M transition for the mammalian cell cycle has been modeled using 19 states to investigate the G2 checkpoint dynamics in response to oxidative stress. A detailed network model of G2/M regulation is presented and then a “core” subsystem is extracted from the full network. An existing model of Mitosis control is extended by adding two important pathways regulating G2/M transition in response to DNA damage induced by oxidative stress. Model predictions indicate that the p53 dependent pathway is not required for initial G2 arrest as the Chk1/Cdc25C pathway can arrest the cell in G2 right after DNA damage. However, p53 and p21 expression is important for a more sustained G2 arrest by inhibiting the Thr161 phosphorylation by CAK. By eliminating the phosphorylation effect of Chk1 on p53, two completely independent pathways are obtained and it is shown that it does not affect the G2 arrest much. So the p53/p21 pathway makes an important, independent contribution to G2 arrest in response to oxidative stress, and any defect in this pathway may lead to genomic instability and predisposition to cancer. Such strict control mechanisms probably provide protection for survival in the face of various environmental changes. The controversial issue related to the mechanism of inactivation of Cdc2 by p21 is addressed and simulation predictions indicate that G2 arrest would not be affected much by considering the direct binding of p21 to Cdc2/Cyclin B given that the inhibition of CAK by p21 is already present if the binding efficiency is within a certain range. Lastly, we show that the G2 arrest time in response to oxidative stress is sensitive to the p53 synthesis rate.
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Matsunuma, R., DW Chan, B.-J. Kim, P. Singh, A. Han, A. Saltzman, C. Cheng et al. "Abstract P5-08-01: DPYSL3 modulates mitosis, migration and epithelial to mesenchymal transition in claudin-low breast cancer". In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p5-08-01.
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Song, Chunhua, Chandrika Gowda, Yali Ding, Kimberly J. Payne e Sinisa Dovat. "Abstract A21: Epigenetic regulation of cell cycle progression at the G2/M transition and mitosis in high-risk leukemia". In Abstracts: AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; February 28 - March 2, 2016; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3125.cellcycle16-a21.
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Kaushik, M., e Gopalkrishna Joshi. "Transitional Learning Style Preferences and Its Factors in Newer Generation Engineering Students". In 2016 IEEE 4th International Conference on MOOCs, Innovation and Technology in Education (MITE). IEEE, 2016. http://dx.doi.org/10.1109/mite.2016.059.
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Singh, Tripti, Puneet Kapur, Sandeep C. Chaudhary, Craig A. Elmets, Levy Kopelovich e Mohammad Athar. "Abstract 952: Nitric oxide donor sulindac inhibits photocarcinogenesis by modulating epithelial mesenchymal transition and mitogen activated protein kinase signaling in SKH-1 hairless mouse skin". In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-952.
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Kulman, J., D. Gray, S. Sivanagere e S. Guffey. "LDV and PIV Velocity Results in a Thermosiphon". In ASME/JSME 2003 4th Joint Fluids Summer Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/fedsm2003-45601.
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Heat transfer and flow characteristics have been determined for a single-phase rectangular loop thermosiphon. The plane of the loop was vertical, and tests were performed with in-plane tilt angles ranging from 3.6° CW to 4.2° CCW. Velocity profiles were measured in one vertical leg of the loop using both a single-component Laser Doppler Velocimeter (LDV), and a commercial Particle Image Velocimeter (PIV) system. The LDV data and PIV data were found to be in good agreement. The measured average velocities were approximately 2–2.5 cm/s at an average heating rate of 70 W, and were independent of tilt angle. Significant RMS fluctuations of 10–20% of the mean velocity were observed in the test section, in spite of the laminar or transitional Reynolds numbers (order of 700, based on the hydraulic diameter). These fluctuations have been attributed to vortex shedding from the upstream temperature probes and mitre bends, rather than to fully developed turbulence. Animations of the PIV data clearly show these large scale unsteady flow patterns. Multiple steady state flow patterns were not observed.
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Olivares, Catalina, e José Eugenio Rubilar Medina. "Desplazamiento del retrato fotográfico: transito del espacio íntimo al espacio social y público." In III Congreso Internacional de Investigación en Artes Visuales :: ANIAV 2017 :: GLOCAL. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/aniav.2017.5230.
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En esta comunicación convergen indagaciones sobe el retrato como código. En esta oportunidad, el retrato pictórico y fotográfico de dos casos chilenos: la figura naval de Arturo Prat y los retratos fotográficos de Detenidos Desaparecidos (D.D) en dictadura militar (1973-1990). En estos dos modos el retrato es un código visual que abre cuestionamientos en torno a quién ve el retrato, cómo se ve este y qué lugar ocupa, estableciendo relaciones entre testimonio, poder y memoria. Profundizaremos en el retrato pictórico decimonónico del capitán de fragata, que se explicita en la distinción del estatus militar en su contexto privado, y se reconfigura en la escena pública como hombre de armas mitificado en la figura de héroe. Dicha significación acompaña el cambio del código del retrato pictórico, que transita hacia espacios de hiperrepresentación global, en el que se inscriben nuevos discursos. El segundo caso navega en el origen y tránsito del retrato del D.D, que va desde la fotografía del álbum familiar a una imagen incluida a la vida pública como retrato-cartel. Aquí la imagen se posiciona como reclamación social, suponiendo un cambio en el significado del mismo retrato. El paso va desde la esfera privada a la pública, así como un pasaje entre el retrato que individualiza al sujeto con sus características personales, a un sujeto cuya identidad visual (la fotografía con rigurosidad) se disuelve para dar paso a un símbolo que aglutina la idea global de quienes han desaparecido. En ambos casos el retrato como transición y transacción de discursos que van de lo local a lo global, opera en una forma simbólica. El retrato adquiere entonces una condición orgánica que se tiñe del propio devenir social y que, en estos casos, levanta la tensión del retrato como testimonio, como reclamación social y como mito que refuerza oficialidad.http://dx.doi.org/10.4995/ANIAV.2017.5230
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Aguilar Alonso, Raquel. "Del mito de Frenhofer a Giorgio Morandi: Una reflexión sobre el modelo en la pintura moderna". In VI Congreso Internacional de Investigación en Artes Visuales ANIAV 2024. València: Editorial Universitat Politècnica de València, 2024. http://dx.doi.org/10.4995/aniav2024.2024.18860.
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Los pintores que desarrollan su obra bajo principios visuales tomados de la naturaleza transitan un proceso inicial de observación que les permite alcanzar "el motivo", es decir, una abstracción propia, autónoma del referente natural que les sirve de pretexto. El mito de Frenhofer, como personaje que cuestiona la representación en los términos convencionalmente establecidos se imprime en la modernidad y se personifica en pintores como Cézanne que sirven de referente durante las grandes trasformaciones que sufre la pintura tras las vanguardias y la irrupción de la pintura abstracta. Nos preguntamos, a través de la obra de algunos pintores que persisten en la figuración durante el siglo veinte, qué es realmente lo que está en juego cuando se cuestiona la representación espacial de una figura u objeto sobre la superficie del lienzo. En este sentido, nos detenemos en la obra de Giorgio Morandi, que puede arrojar algo de luz en esta tesitura gracias a la estrecha relación que mantienen sus bodegones con el modelo, y a su propia evolución, que le llevará en los últimos años de su vida a una síntesis cada vez mayor del espacio y del claroscuro.
Relatórios de organizações sobre o assunto "Transition mitose"
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Joukov, Vladimir. The Role of BRCA1/BARD1 Heterodimers in the Mitosis-Interphase Transition. Fort Belvoir, VA: Defense Technical Information Center, maio de 2007. http://dx.doi.org/10.21236/ada471801.
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