Literatura científica selecionada sobre o tema "Trans Frau"
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Artigos de revistas sobre o assunto "Trans Frau"
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Schneider, Florian, Stefan Schlatt, Nina Neuhaus e Sabine Kliesch. "Fertilätsprotektion bei Mann-zu-Frau trans Personen: Früh an fertilätsprotektive Maßnahmen denken". Zeitschrift für Sexualforschung 33, n.º 03 (setembro de 2020): 169–71. http://dx.doi.org/10.1055/a-1216-7015.
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ZusammenfassungWir stimmen dem in der Leitlinie genannten starken Konsens für Maßnahmen der Reproduktionsmedizin als wichtige Option zur Erfüllung des Kinderwunsches bei trans Personen uneingeschränkt zu. Informationen über diese Maßnahmen müssen Bestandteil von Behandlungen von trans Personen sein. Die geschlechtsangleichende Hormontherapie bei Mann-zu-Frau trans Personen hat jedoch einen negativen Einfluß auf die Spermatogenese. Der Erfolg der Fertiltätsprotektion bei Mann-zu-Frau trans Personen hängt stark von Qualität und Quantität der Spermien bzw. der spermatogonialen Stammzellen ab. Daher sollte die Beratung vor der geschlechtsangleichenden Hormontherapie stattfinden. Zu Beginn sollten eine ausführliche Anamnese, eine körperliche Untersuchung, eine Untersuchung von Serumhormonen (LH, FSH, Testosteron, Östradiol, AMH, Inhibin B) und ggf. eine Untersuchung des Ejakulats erfolgen. Zu den etablierten Methoden der Fertilitätsprotektion zählen Kryokonservierung von Spermien nach Ejakulation, Kryokonservierung von Spermien nach mikrochirurgischer testikulärer Spermienextraktion (mTESE) oder Spermienaspiration aus dem Nebenhoden (MESA) oder Kryokonservierung von spermatogonialen Stammzellen. Letztere sind auch möglich, wenn die geschlechtsangleichende Hormontherapie vor Beginn der Pubertät begonnen wird. Dies ist derzeit noch experimentell. Kryokonservierte Spermien können dazu verwendet werden, im Rahmen einer In-vitro-Fertilisation (IVF) und intrazytoplasmatischen Spermieninjektion (ICSI) mit Frauen eigene Kinder zu zeugen. Leihmutterschaft oder Eizellenspende ist in Deutschland derzeit nicht möglich.Wir wollen betonen, dass das Gespräch über fertilitätsprotektive Maßnahmen so früh wie möglich stattfinden muss, um den Erfolg zu garantieren und Absprachen zwischen den medizinischen Diszplinen zu ermöglichen. Das Ziel sind individuelle Lösungen, die für trans Personen finanzierbar, gangbar und operativ mit einfachen Mitteln zu erreichen sind.
2
Hamm, Jonas A., e Timo O. Nieder. "Trans*-Sexualität neu denken: Eine partizipative Interviewstudie zu gelingender Sexualität ohne Genitalangleichung". Zeitschrift für Sexualforschung 34, n.º 02 (junho de 2021): 69–78. http://dx.doi.org/10.1055/a-1477-0412.
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Zusammenfassung Einleitung Studien zur Sexualität von trans* Personen sind häufig durch das heteronormative Bias geprägt, alle trans* Personen würden eine Genitalangleichung anstreben, um penil-vaginalen penetrativen Geschlechtsverkehr ausüben zu können, als (trans*) Mann in der insertiven, als (trans*) Frau in der aufnehmenden Rolle. Diese Studie untersucht erstmals die Sexualität von trans* Personen, die keine Genitalangleichung anstreben und mit ihrer Sexualität zufrieden sind. Forschungsziele Ziel der Studie ist es, die individuelle Sexualität von Menschen dieser Personengruppe zu beleuchten und die intrapsychischen, interaktionellen und kollektiven Ressourcen zu analysieren, auf die sie dabei zurückgreifen. Darunter fallen auch Strategien, um den scheinbaren Widerspruch von Geschlechtsidentität und Körperlichkeit zu überbrücken. Methoden Es wurden sechs leitfadengestützte qualitative Interviews durchgeführt und mithilfe einer inhaltlich strukturierenden qualitativen Inhaltsanalyse ausgewertet. Die Studie beinhaltete verschiedene partizipative Elemente. So wurden die Ergebnisse im Rahmen einer partizipativen Feedbackschleife durch die Teilnehmenden kommunikativ validiert. Ergebnisse Die Teilnehmer_innen berichten von vielfältigen, genitalen wie non-genitalen sexuellen Praktiken, die unabhängig von den damit assoziierten Geschlechterrollen stattfinden. Dabei greifen sie auf verschiedene Ressourcen und Strategien zurück. Insbesondere wird die geschlechtsanzeigende Funktion von Genitalien auf drei Ebenen dekonstruiert: individuell durch die Teilnehmenden selbst, interaktionell über die Anerkennung ihrer Geschlechtsidentität durch sexuelle Partner_innen und kollektiv durch die Communitys, in denen sie sich bewegen. Schlussfolgerung Die Studie entkräftet die oft unhinterfragte Vorannahme, dass trans* Personen per se ihre Genitalien nur widerwillig oder unter Erfahrungen von körperlicher Dysphorie in der Sexualität einsetzen. Mit den richtigen Ressourcen müssen sexuelle Rolle, Genitalienstatus und Geschlechtsidentität nicht stereotyp zusammenfallen, um gelingende Sexualität zu praktizieren.
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Scholz, Janek. "Künste des Dazwischen als Künste der Transgression". apropos [Perspektiven auf die Romania], n.º 10 (30 de junho de 2023): 170–90. http://dx.doi.org/10.15460/apropos.10.1967.
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Diana Salus Text cartas para ninguém (2019) verbindet Lyrik, Comic, Autobiografie und Skizzenbuch. Das transversale Kreuzen gesellschaftlicher Rahmungen steht in besonderer Weise mit der Identität der Autorin als lesbischer trans* Frau in Verbindung. Die vorliegende Untersuchung analysiert das Zusammenspiel zwischen Genre und Gender in Salus Text und stellt die These auf, dass dieser als ein Text im Werden zu verstehen ist, als ein unentwegtes Anschreiben gegen Zuschreibungsprozesse. Gerade die gezielte Verschiebung der Aufmerksamkeit auf die freien Flächen, die leeren Stellen und die Stille machen Salus Werk zu einem Werk des Dazwischen, das die Leser*innen dazu auffordert, sich einerseits mit den eigenen Sehgewohnheiten auseinanderzusetzen und andererseits in Beziehung zu treten und darüber handlungswirksam zu werden.
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Bohle, Ulrike. "Strategien und Mittel des Genderns zwischen Verfestigung und Destabilisierung von Geschlecht". Betrifft Mädchen, n.º 2 (28 de abril de 2020): 56–61. http://dx.doi.org/10.3262/bem2002056.
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40 Jahre nach Erscheinen der ersten „Richtlinien zur Vermeidung sexistischen Sprachgebrauchs“ ist ihre Notwendigkeit und Legitimität immer noch umstritten. Leitfäden zur geschlechtergerechten Sprache werden einerseits als unzulässiger Eingriff in die Sprache zurückgewiesen, andererseits wird vor einer Verfestigung normativer Geschlechtermodelle gewarnt. Entstanden sind die ersten Empfehlungen im Kontext der neuen Frauenbewegung aus Kritik an der Diskriminierung von Frauen in und durch Sprache. Feministische Sprachkritik wurde bald in der Gesetzgebung aufgegriffen (s. Stickel 1988: 333 f., Schoenthal 1989: 298 f., Kusterle 2011: 19-21 u. a.) und ist heute Teil von Gender Mainstreaming (Wetschanow 2017) – bis vor kurzem implizit gedacht als Gleichstellung von Mann und Frau. Erst das Erstarken der Trans*- und Inter*-Bewegung seit den 1990er Jahren führte zur rechtlichen Anerkennung eines dritten/unbestimmten Geschlechts (§ 22 Abs. 3 PStG). Eng verwoben mit der Frauen- wie der Schwulen-/Lesben-/Bi-/Trans-/Inter*-Bewegung ist die Entwicklung der Frauenund Geschlechterforschung und der queer studies. Im Zusammenwirken von sozialen Bewegungen, Wissenschaft und Gesetzgebung haben sich im Laufe der Jahre verschiedene Formen des Genderns entwickelt. Ziel des Beitrags ist es, die Diskussion zu systematisieren. Im ersten Schritt sollen sprach- und geschlechtertheoretische Grundpositionen skizziert werden, aus denen sich bestimmte sprachpolitische Strategien ableiten lassen. Im zweiten Schritt sollen diesen Strategien die verschiedenen Formen zugeordnet werden.
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Kühn, Shafreena, Andrej Wehle, Marcus Kiehlmann e Ulrich Michael Rieger. "Patientenzufriedenheit nach geschlechtsangleichender Mastektomie in Frau-zu-Mann-transidenten Patienten – eine Analyse unter Verwendung eines modifizierten BREAST-Q-Fragebogens". Handchirurgie · Mikrochirurgie · Plastische Chirurgie 53, n.º 06 (dezembro de 2021): 564–71. http://dx.doi.org/10.1055/a-1640-0295.
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Zusammenfassung Hintergrund Die Mastektomie ist essenzieller Bestandteil der geschlechtsangleichenden Operationen in der Gruppe Frau-zu-Mann(FM)-transidenter Patienten. Einschlägige Studien zeigen eine hohe Patientenzufriedenheit in dieser Kohorte, allerdings etablierte sich bisher kein standardisiertes Verfahren zur Evaluation der Effektivität. Methoden Anhand des etablierten Breast-Q-Fragebogens entwickelten wir eine modifizierte Version unter Berücksichtigung spezifischer Fragestellungen hinsichtlich FM-transidenter Patienten. Demnach erfolgte die Anpassung aller Fragen, welche gezielt die Physiologie von Cis-Frauen adressieren. Im Sinne eines „One-Group Post-Test Only“-Designs kontaktierten wir Patienten nach stattgehabter Mastektomie im Zeitraum von 1991 bis 2017 und evaluierten die Ergebnisse des Fragebogens von insgesamt 28 Patienten. Letzterer beinhaltet 57 Fragen hinsichtlich der grundlegenden Zufriedenheit mit der Brustregion, ebenso wie spezifische Fragen zur Zufriedenheit mit dem Mamillen-Areola-Komplex und hinterfragt Themen wie Erwartungen, Selbstbewusstsein, Sexualleben und Bedauern nach erfolgter Mastektomie. Ergebnisse Insgesamt zeigte sich ein hohes Maß an Patientenzufriedenheit nach stattgehabter Mastektomie. Alle befragten Patienten würden den Eingriff wiederholen und nur wenige äußerten Bedauern. Konklusion Die Mastektomie spielt eine entscheidende Rolle hinsichtlich geschlechtsangleichender Eingriffe bei Trans-Männern und zeigt eine hohe postoperative Zufriedenheit als Ausdruck einer Lebensqualitätsverbesserung.
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Grumstrup, Morten. "Fra LBL til LGBT". Culture and History: Student Research Papers 6, n.º 1 (2 de janeiro de 2022): 62–84. http://dx.doi.org/10.7146/chku.v6i1.129545.
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Denne artikel undersøger trans-inklusionen i 2008 i den daværende Landsforeningen for bøsser og lesbiske, samt udviklingen fra en bøsse-lesbisk forening til en LGBT-forening. Analysen viser at udviklingen til en LGBT-forening begyndte allerede i 1999 da et medlem af foreningens egen ledelse stod frem som transkønnet. Analysen viser at delte livserfaringer (’approximations’) mellem transpersoner og homo- og biseksuelle personer var vigtige for opnåelsen af en trans-inklusion, og dermed en LGBT-udvikling. Analysen viser ydermere at den danske trans-inklusion ikke endte i en kunstig implementering, modsat mange amerikanske
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Straayer, Chris. "Trans men’s stealth aesthetics: navigating penile prosthetics and ‘gender fraud’". Journal of Visual Culture 19, n.º 2 (agosto de 2020): 255–71. http://dx.doi.org/10.1177/1470412920946827.
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This article examines trans commercial production of penile prosthetics, the efficacy of such products in personal and sex-segregated spaces, and their negative valence in the public sphere. Responding to his own experience of gender dysphoria, Transthetics founder Alex designs and produces products for the reparative and enabling embodiment of trans men. Penile prosthetics reflect the longstanding tension between aesthetics and function in the history of prosthetic limbs. The author posits ‘stealth aesthetics’ as a function-injected realism that pushes into reality via utilization of prosthetics in the performance of real life. For some trans men, the phenomenologically incorporated prosthetic is tantamount to a corporeal penis. Cisnormativity, however, outlaws this equivalence. Recent prosecutions of penile prosthetic embodiment as ‘gender fraud’ punitively restrict trans men’s claim on reality, instead exposing their private bodies to public judgment, where genitals produce gender. By contrast, the author advocates the authorization of gender to produce genitals.
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Mau, Søren. "Fra væsen til stoftskfite - Marx' arbejdsbegreber". Slagmark - Tidsskrift for idéhistorie, n.º 76 (25 de janeiro de 2018): 95–111. http://dx.doi.org/10.7146/slagmark.v0i76.124161.
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FROM ESSENCE TO METABOLISM - MARX'S CONCEPTS OF WORKThe Marxist tradition is marked by a persistent conflict about the analytical as well as tactical use of the concept of labour: Is labour a trans-historical necessity, or is it rather a specific capitalist phenomenon that should be abolished along with capital and the state? The article shows how these theoretical and tactical conflicts can be traced back to certain ambiguities in the writings of Marx, taken as a whole. Furthermore, the article argues that Marx’s use of the concept can be divided into three periods: (I) In 1844, the concept of labour was a anthropological notion designating the trans-historical essence of the human being and occupying an explanatory and critical function in the critique of bourgeois society. (II) In 1845-48, the trans-historical use of the concept disappears and gives way to a distinction between activity and labour. The latter is now conceptualised as something specific to capitalism. (III) From 1857 onwards, Marx develops a new trans-historical concept of labour, inspired by the concept of metabolism. However, this concept does not have the explanatory and critical function that the early concept of labour had.
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Nichols Busch, Tracy. "The High Line". Transfers 1, n.º 2 (1 de junho de 2011): 136–40. http://dx.doi.org/10.3167/trans.2011.010209.
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An abandoned freight track on Manhattan’s West Side, considered by local businesses to be nothing more than an eyesore and an impediment to development, became the cause célèbre of New Yorkers in the early twenty-first century. Efforts to “save the High Line” resulted in one of the largest creations of public space in New York history. The 8.8 metertall High Line, which stretches 12 blocks between Ganesvoort Street and 20th Street, features both permanent and temporary art installations that inform visitors of their movement through space and its implication for the natural and constructed worlds. A post-industrial yearning for a more harmonious relationship between humans and the natural world can be detected in New Yorkers’ affection for the High Line. The elevated nature of this raised railroad track creates an ethereal and otherworldly sensation. The traffic below becomes an abstraction and pedestrians, always vulnerable on the streets, are lifted above the fray.
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Xie, Linjun, Liying Zou, Jie Chen e Youxue Liu. "All-Trans Retinoic Acid Inhibits Bone Marrow Mesenchymal Stem Cell Commitment to Adipocytes via Upregulating FRA1 Signaling". International Journal of Endocrinology 2020 (31 de janeiro de 2020): 1–11. http://dx.doi.org/10.1155/2020/6525787.
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Obesity, caused by an increased number and volume of adipocytes, is a global epidemic that seriously threatens human health. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into adipocytes. All-trans retinoic acid (atRA, the active form of vitamin A) inhibits the adipogenic differentiation of BMSCs through its receptor RARG. The expression level of FRA1 (FOS like 1, AP-1 transcription factor subunit) in atRA-treated BMSCs increased, suggesting that atRA-mediated inhibition of BMSCs adipogenesis involves FRA1. BMSCs were transfected with adenovirus overexpressing Fra1 (ad-fra1) or silenced for Fra1 (si-fra1) and then treated with atRA. BMSCs treated with atRA and treated with ad-fra1 showed decreased mRNA and protein levels of key adipogenic genes (Pparg2, Cebpa) and adipogenesis-associated genes (Cd36, Fabp, Lpl, and Plin); atRA had a stronger inhibitory effect on adipogenesis compared with that in the ad-fra1 group. Adipogenic gene expression in Fra1-silenced BMSCs was significantly upregulated. Compared with that in the atRA group, the si-fra1 + atRA also upregulated adipogenic gene expression. However, compared with si-fra1, si-fra1 + atRA significantly inhibited adipogenic differentiation. Chromatin immunoprecipitation showed that RARG directly regulates Fra1 and FRA1 directly regulates Pparg2 and Cebpa. The results supported the conclusion that atRA inhibits BMSC adipogenesis partially through the RARG-FRA1-PPARG2 or the CEBPA axis or both. Thus, vitamin A might be used to treat obesity and its related diseases.
Teses / dissertações sobre o assunto "Trans Frau"
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LIU，CHIEN-KUO e 劉建國. "A Research on Countermeasures of Cross-Strait Trans-boundary Fraud Detection and Prevention". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8rw2e7.
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碩士開南大學
人文社會學院法律碩士在職專班
106
Taiwan’s fraudulent cases have increased dramatically since 2000. This is because fraud groups have used human fears and greed in recent years to exploit emerging technologies such as finance, telecommunications, and the Internet, and their management loopholes, through criminal accounts such as head accounts and head phones. The tools, in a variety of ways, induce victims to go to ATMs for ATMs or remittances, or even go to the local government to withdraw funds, fraudulently plunder money from unsuspecting people, and make huge profits. This is a serious violation of people’s property safety. In the face of increasingly serious fraud cases, the Department of Police has joined forces of various ministries to launch an anti-fraud project since April 15, 2004. With the cooperation of various relevant departments, the Department has launched various defense measures to effectively crack down on Taiwan fraud. Crime in order to suppress the occurrence of fraud cases and ensure the safety of people’s property. Fraud cases have caused major public security threats in Taiwan since 2004. The government has mobilized resources from various departments to fight against it. It has developed relevant measures from the management level, investigative level, and the use of investigative crime techniques, and has implemented various raids through planning to try to suppress fraud. Although the arrogance has been carried out to a certain extent so far, it has still not been able to prevent the occurrence of fraud cases, partly due to "cross-border crimes." The development of fraud cases has so far been not only an issue of public security in an environment, but also a problem of cross-border crimes. Mainland China, Thailand, Indonesia, the Philippines, Malaysia, Cambodia, Vietnam, Laos, Fiji, Sri Lanka, Spain, and Africa Asia, Poland, Croatia, and other places have also been reported as cases. The crime of telecommunication fraud is a new crime on the mainland. Because of lack of information on deterring frauds and weak defensive capabilities, it is estimated that the mainland people will be the next major target of the fraud group. At this moment, we must face up to its hazards and threats. Otherwise, we will miss the opportunity. The loss of people's wealth will be no reason, and the prevention and control of the work will be lost. The "Agreement on Combating Crime and Mutual Legal Assistance across the Taiwan Strait" was signed on April 26, 2009 and came into effect on June 25. When the two sides of the Strait jointly fight against crimes towards a new era, when both sides of the Strait are determined to work together to combat crimes, the development of bilateral and benign interaction based on the principles of reciprocity, dignity, and mutual benefit, and the fight against cross-border fraud are the top priorities. Since the arrival of Cai Yingwen’s incumbent President and the Democratic Progressive Party in 2016, due to the lack of consensus and mutual trust between the new government and the Chinese mainland authorities, the mutual trust between the two sides of the strait has been lost, followed by stagnation of the two sides of the strait, in order to ensure the rights and interests of people on both sides of the strait. Cross-strait exchange order, more importantly, is to maintain cross-strait social harmony and effectively deal with the problems brought about by the close exchanges between the two sides of the strait. Without affecting the state’s power and organization, the “criminal suppression of crimes is not limited by boundaries and politics”. Based on ideas, we hope that we can truly implement human rights protection and create a win-win situation based on mutual respect, reciprocity, and reciprocity. The issue of cross-strait cooperation, when the cross-strait relationship has not been improved, and the identification of the bank has not yet established a positive identity, how to improve the interests of cross-strait cooperation is currently implemented by the government authorities. The establishment and expansion of the cooperative relationship can use the knot of the issue, so that the current cooperation on cross-border telecom fraud and the cooperation of other issues can be combined with the cooperation of other issues, so that the establishment or expansion of the cooperation issue must be carried out to promote cross-border telecommunications fraud. The implementation of criminal cooperation is a prerequisite. The topic of cross-strait cooperation is quite extensive. The Taiwan authorities need to think about the issue of cooperation as a bargaining chip for negotiations with China, or what kind of issue as a concession in exchange for the cooperation of China’s amnesty. The public security departments shall implement the requirements for cooperation. Because the cooperative relationship is not a unilateral request and appeal, it must be the mutual coordination of the two sides. With some retreat, the two sides can form a common goal and enhance the interests.
2
Ait, Hamouda Hocine. "Étude du trafic cellulaire de la convertase de proprotéine PCSK9 responsable de la dégradation du récepteur des lipoprotéines de faible densité (LDLR)". Thèse, 2014. http://hdl.handle.net/1866/11842.
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Les maladies cardiovasculaires (MCV) sont la principale cause de mortalité dans
les pays industrialisés. L'hypercholestérolémie constitue un facteur de risque majeur pour
les MCV. Elle est caractérisée par des niveaux élevés de lipoprotéines de faible densité
(LDL, aussi appelé “mauvais cholestérol”). La présence prolongée de haut niveaux de
LDL dans la circulation augmente le risque de formation de plaques athérosclérotiques,
ce qui peut conduire à l'obstruction des artères et l'infarctus du myocarde. Le LDL est
normalement extrait du sang par sa liaison au récepteur du LDL (LDLR) qui est
responsable de son endocytose dans les hépatocytes. Des études génétiques humaines ont
identifié PCSK9 (proprotein convertase subtilisin/kexin type 9) comme le troisième locus
responsable de l'hypercholestérolémie autosomique dominante après le LDLR et son
ligand l’apolipoprotéine B-100. PCSK9 interagit avec le LDLR et induit sa dégradation,
augmentant ainsi les niveaux plasmatiques de LDL. Les mutations gain de fonction (GF)
de PCSK9 sont associées à des niveaux plasmatiques élevés de LDL et à l'apparition
précoce des MCV, alors que les mutations perte de fonction (PF) de PCSK9 diminuent le
risque de MCV jusqu’à ~ 88% grâce à une réduction du LDL circulant. De ce fait,
PCSK9 constitue une cible pharmacologique importante pour réduire le risque de MCV.
PCSK9 lie le LDLR à la surface cellulaire et/ou dans l'appareil de Golgi des hépatocytes
et provoque sa dégradation dans les lysosomes par un mécanisme encore mal compris. Le
but de cette étude est de déterminer pourquoi certaines mutations humaines de PCSK9
sont incapables de dégrader le LDLR tandis que d'autres augmentent sa dégradation dans
les lysosomes. Plusieurs mutations GF et PF de PCSK9 ont été fusionnées à la protéine
fluorecente mCherry dans le but d'étudier leur mobilité moléculaire dans les cellules
hépatiques vivantes. Nos analyses quantitatives de recouvrement de fluorescence après
photoblanchiment (FRAP) ont montré que les mutations GF (S127R et D129G) avaient
une mobilité protéique plus élevée (> 35% par rapport au WT) dans le réseau trans-
Golgien. En outre, nos analyses quantitatives de recouvrement de fluorescence inverse
après photoblanchiment (iFRAP) ont montré que les mutations PF de PCSK9 (R46L)
avaient une mobilité protéique plus lente (<22% par rapport au WT) et une fraction
mobile beaucoup plus petite (<40% par rapport au WT). Par ailleurs, nos analyses de
microscopie confocale et électronique démontrent pour la toute première fois que PCSK9
est localisée et concentrée dans le TGN des hépatocytes humains via son domaine Cterminal
(CHRD) qui est essentiel à la dégradation du LDLR. De plus, nos analyses sur
des cellules vivantes démontrent pour la première fois que le CHRD n'est pas nécessaire à
l'internalisation de PCSK9. Ces résultats apportent de nouveaux éléments importants sur
le mécanisme d'action de PCSK9 et pourront contribuer ultimement au développement
d'inhibiteurs de la dégradation du LDLR induite par PCSK9.Coronary heart diseases (CHD) are a leading cause of death in Western societies. Hypercholesterolemia is a major risk factor for CHD. It is characterized by high levels of circulating low-density lipoprotein cholesterol (LDL, also called "bad cholesterol"). The prolonged presence of elevated levels of LDL in the circulation increases the risk of formation of atherosclerotic plaques, which can lead to obstruction of arteries and myocardial infarction. LDL is normally cleared from the blood through the binding of its sole protein constituent apolipoprotein B100 to hepatic LDL receptor (LDLR), which mediates its endocytosis in the liver. Human genetic studies have identified PCSK9 as the third gene responsible of autosomal dominant hypercholesterolemia after LDLR and its ligand apolipoprotein B100. PCSK9 interacts with the LDLR and induces its degradation thereby causing plasma LDL levels to rise. PCSK9 gain-of-function (GOF) mutations are associated with elevated plasma LDL levels and premature CHD while PCSK9 loss-offunction (LOF) mutations reduce the risk of CHD up to ~88% owing to reduction of circulating LDL. Accordingly, PCSK9 is recognized as a major pharmacological target to lower the risk of CHD. PCSK9 binds the LDLR at the cell surface and/or in the Golgi apparatus of hepatocytes and causes its degradation in lysosomes by a mechanism not yet clearly understood. The goal of this study was to determine why some human PCSK9 mutations fail to induce LDLR degradation while others increase it in lysosomes. Several PCSK9 LOF and GOF mutations were fused to the fluorescent protein mCherry to study their molecular mobility in living human liver cells. Our quantitative analysis of fluorescence recovery after photobleaching (FRAP) showed that PCSK9 GOF mutations S127R and D129G have a higher protein mobility (>35% compared to WT) at the trans- Golgi network (TGN). Our quantitative analysis of inverse fluorescence recovery after photobleaching (iFRAP) showed that PCSK9 LOF mutation R46L presented a much slower protein mobility (<22% compared to WT) and a much slower mobile fraction (<40% compared to WT). In addition, our confocal and electron microscopy analyses demonstrate for the first time that PCSK9 is localized and concentrated at the TGN of human hepatocytes. Furthermore, our results demonstrate that PCSK9 localization in the TGN is mediated through its C-terminal cysteine and histidine-rich domain (CHRD), which is essential for LDLR degradation. Also, our live-cell analyses demonstrate for the first time that the CHRD is not required for internalization of PCSK9. These results provide important new information on the mechanism of action of PCSK9 and may ultimately help in the development of inhibitors of the PCSK9-induced LDLR degradation.
Livros sobre o assunto "Trans Frau"
1
Albuquerque, Fernanda Farias de. A princesa. Rio de Janeiro, RJ, Brasil: Editora Nova Fronteira, 1995.
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2
Albuquerque, Fernanda Farias de. Princesa. Roma: Sensibili alle foglie, 1994.
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3
Elsner, Constanze, ed. Ich war ein Mann: Die Lebensgeschichte einer Transsexuellen. Rastatt, Germany: Hestia, 1992.
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4
Appleby, Steven. Dragman. London, UK: Jonathan Cape, 2020.
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5
Office, General Accounting. [Waste, fraud, and abuse under the State and Local Fiscal Assistance Act of 1972]. Washington, D.C: The Office, 1992.
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Great Britain. Parliament. House of Commons. European Scrutiny Committee. Ninth report of session 2003-04: Documents considered by the Committee on 4 February 2004, including: levels of certain heavy metals and polycyclic aromatic hydrocarbons in ambient air, Registration, evaluation and authorisation of chemicals(REACH), Trans-European transport network, Review of the Working Time Directive, 2002 annual report of the European Court of Auditors, Activity of the European Anti-Fraud Office : report, together with formal minutes. London: Stationery Office, 2004.
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Trans. Frau. Sein.: Aspekte geschlechtlicher Marginalisierung. 2a ed. Münster, Germany: Edition Assemblage, 2020.
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Trans. Frau. Sein.: Aspekte geschlechtlicher Marginalisierung. Münster, Germany: Edition Assemblage, 2018.
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Ein Leben im Anderssein. Mein Ich. Literareon, 2002.
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Mein Leben im Anderssein: Mein Ich. München, Germany: Literareon im Herbert Utz Verlag, 2002.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Trans Frau"
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Gebhardt, Christiane. "Corporate non-compliance and corporate identity building – A management dilemma. Early indicators of organizationally driven deviance traps". In Bribery, Fraud, Cheating, 247–83. Wiesbaden: Springer Fachmedien Wiesbaden, 2020. http://dx.doi.org/10.1007/978-3-658-29062-7_15.
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Gebhardt, Christiane. "Correction to: Corporate non-compliance and corporate identity building – A management dilemma. Early indicators of organizationally driven deviance traps". In Bribery, Fraud, Cheating, C1. Wiesbaden: Springer Fachmedien Wiesbaden, 2020. http://dx.doi.org/10.1007/978-3-658-29062-7_18.
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"Gesundheit »jenseits der Mann/Frau-Binarismen«". In Trans & Care, 103–24. transcript-Verlag, 2019. http://dx.doi.org/10.14361/9783839445990-007.
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Houben, Malin, Gabriele Dennert, Muriel González Athenas e Constance Ohms. "Gesundheit »jenseits der Mann/Frau-Binarismen«". In Trans & Care, 103–24. transcript Verlag, 2019. http://dx.doi.org/10.1515/9783839445990-007.
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Matern, Harald. "…und schuf sie als Mann und Frau. Ethische Herausforderungen transidenter Individualität aus theologischer Perspektive". In Inter* und Trans*identitäten, 135–54. Psychosozial-Verlag, 2016. http://dx.doi.org/10.30820/9783837969931-135.
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Prüll, Livia. "Das Selbstbild der transidenten Frau nach 1945 und die Konsequenzen für den Umgang mit Geschlechtsidentitäten". In Inter* und Trans*identitäten, 31–56. Psychosozial-Verlag, 2016. http://dx.doi.org/10.30820/9783837969931-31.
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"Fertilitätsprotektion bei Mann-zu-Frau-Trans-Personen (Florian Schneider, Stefan Schlatt, Nina Neuhaus & Sabine Kliesch)". In Geschlechtsinkongruenz, Geschlechtsdysphorie und Trans-Gesundheit, editado por Timo O. Nieder e Bernhard Strauß, 351–59. Nomos Verlagsgesellschaft mbH & Co. KG, 2021. http://dx.doi.org/10.30820/9783837977585-351.
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Harvey, Brian W., e Carla J. Shapreau. "Business or Pleasure -- Legal Traps". In Violin Fraud, 34–38. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198166559.003.0004.
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Abstract In the violin world there are broadly three classes of person interested in stringed instruments. First there is the player or teacher. Players and teachers very often form the end link of the chain: the consumer in a true sense, for whom the product exists. Then there is the collector. Collectors have occupied a ubiquitous position for some centuries. Collecting violins is almost as old as their manufacture. But it became a more com mon pursuit in the nineteenth century when a larger number of connoisseurs began to appreciate the violin as a valuable artefact.
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"Fray Justo Santa Marfa de Oro". In Recollections Of A Provincial Past, editado por Elizabeth Garrels e Asa Zatz, 59–69. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195113709.003.0009.
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Abstract Among those rascals, rowdies, and pranksters who were Don Miguel’s sons, Justo, the eldest, stood out in contrast for the evenness of his temper and the tranquility of his contemplative soul. As a boy, he was relentlessly harassed by his brothers Jose and Antonio. They would pummel him with pillows when he was trying to sleep, pee in his boots when he was about to get up, and vex him every which way all day long, laying traps for him, accusing him to their stern mother of pranks they themselves had played to get him in trouble.
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Hussien, Nadia Mahmood, e Yasmin Makki Mohialden. "An Overview of Fraud Applications and Software on Social Media". In Advances in Multimedia and Interactive Technologies, 1–11. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-6060-3.ch001.
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Fraud involves intentional deception. While the victim's rights are violated, the criminal profits from the situation. Fraud can be committed by individuals, groups, or even entire companies. The importance of social media cannot be overstated. The management of natural disasters and medical difficulties are both handled through social media. The use of social media has resulted in the establishment of a marketplace for goods and services. Because social networking has evolved into a money-making opportunity, dishonest users now cheat in many ways. Fraud on social media platforms has been on the rise. Cybercriminals exploit unethical social engineering to steal data. Indicators of fraud include excessive pressure, a broad scope, honey traps, and justification. People who are unaware of something lose both money and information. In the current environment, information technology professionals are unable to protect social media users from being scammed or spammed.
Trabalhos de conferências sobre o assunto "Trans Frau"
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Landau, Stuart A., e Daniel J. Reitz. "Relays to Processors at the Port Authority Trans-Hudson". In 2013 Joint Rail Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/jrc2013-2424.
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The Port Authority Trans-Hudson (PATH) heavy-rail rapid-transit system has a two-decade history of using microprocessor-based equipment as replacements for electromechanical and electrical systems. Until recently, these processors were used for non-vital applications only, such as event recording and train dispatching. With the rebuilding of the World Trade Center terminal, processors were introduced for vital applications. PATH is now in the midst of a processor-based replacement of its entire signal system. Here we present a review of past, current and future applications of processor-based equipment at PATH. We examine the reasons for conversion and the advantages and disadvantages for design, installation and maintenance. A survey is made of equipment that is removed, added, replaced or retained for processor-based conversion. Interfacing with field appliances, including the continued use of relays for limited applications, is examined. With so much functionality concentrated within a single piece of equipment, new types of failure modes and redundancy become important considerations, as well as the volatility of critical information needed to maintain service. We also expose the problems of testing and cutover of new equipment on a railroad that operates passenger service 24 hours a day, 365 days a year, and training requirements of signal office staff and field forces. Since PATH is under FRA jurisdiction, use of processor-based equipment for vital applications is subject to additional regulations and we look at the programming accommodations for FRA testing.
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Scales, Brian T. "Estimated Weight Increase Resulting From Modifying European Trains to Meet Federal Railroad Administration Safety Rules". In 2010 Joint Rail Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/jrc2010-36021.
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It is claimed by the European train manufacturers that adapting existing European high-speed train technologies to satisfy the Safety Rules of the Federal Railroad Administration (FRA) for rail passenger vehicles to be operated in the USA would result in a significant and uneconomic weight increase. A methodology was required for the estimation of this weight increase so that performance calculations can be undertaken of European high-speed train technologies that have been modified to suit the FRA Safety Rules.
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Hunter-Zaworski, Katharine, Kristine Severson e Melissa Shurland. "Containment for Occupied Wheeled Mobility Devices on Passenger Rail Trains". In 2018 Joint Rail Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/jrc2018-6119.
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The paper addresses the need to examine the trade-offs between passenger safety and independence in travel by people who use wheeled mobility devices on passengers trains. It has been the practice in Asia, North America and Europe to not require passengers in wheeled mobility devices (WhMDs) such as wheelchairs to secure their wheeled devices when traveling by rail. There are several motivations for examining the need for containment of WhMDs on passenger trains. In general the population is aging and getting larger, and this is reflected in the types of WhMDs that passengers are trying to bring on board trains. The US Federal Railroad Administration (FRA) and members of the Rail Vehicle Access Advisory Committee (RVAAC) requested a feasibility study on the economic impacts of accommodating two or more wheeled mobility devices in the accessible seating area [1]. The feasibility study indicated that there is space to accommodate two WhMDs without significant impact on revenue seat loss, however safety issues have emerged, and are the basis of this paper. The three research questions that are addressed include: I. What is the appropriate interior space that accounts for WhMD maneuvering? II. What are the appropriate levels of deceleration and jerk to be considered in the vehicle interior for passenger rail vehicles under severe braking? III. What is the appropriate level of containment for occupied wheeled mobility devices on passenger rail vehicles? The paper examines research literature and other findings from both North America and Europe that address in part the research questions.
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Blaze, James R., Jay Gowan e Stephen Byers. "Critical Logistics Support Enables Fast Track Construction for High Speed Rail". In 2010 Joint Rail Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/jrc2010-36148.
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Paper and PowerPoint presentation format will describe process for much faster logistics and construction management of new high speed track construction and improvement of existing FRA track from FRA Class 4 to Class 5 and Class 6 standards on existing freight railway lines. This process involves an integration of the long materials supply chain together with rapid process state of the art construction machines. These machines have been used in both European and Chinese high speed construction projects. Huge gains in new track kilometers and miles per day have been made in the last decade on the machinery side of the equation. The authors will show several case studies. The critical key to these production rates has been in the integration of materials ordering and prepositioning. The economic advantage is that track time construction windows that delay other passing trains can be reduced at tremendous savings in service and operational costs to the operators already providing service in these new high speed corridors and construction zones. Examples and calculations are shown.
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Twombly, Jeffrey G., Eric D. Cutright e Kenneth K. Jackson. "Cost-Effective Risk Assessment of PTC Systems per FRA Rule 49CFR236 Subpart H". In 2009 Joint Rail Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/jrc2009-63020.
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The US rail industry is charged with developing and implementing interoperable Positive Train Control (PTC) on many lines by 2015. It will be a challenge to assure the overall design safety of this next generation of train control, and there are significant issues with accommodating varying operating methods and different territories. The Federal Railroad Administration (FRA) will also require the railroads to meet the processor-based train control standards in FRA Rule 49CFR236 Sub-Part H (hereinafter FRA Rule 236H) [1], including the requirement for a comparative risk assessment, preferably quantitative. This paper provides an overview of the safety assurance process mandated by the FRA and discusses a cost-effective approach to performing risk assessments on large PTC systems. The paper also recognizes the current FRA and Railroad Safety Advisory Committee (RSAC) effort in developing the new PTC-specific FRA Rule 49CFR236 Sub-Part I to meet the recent PTC legislation requirements. The FRA Rule 236H requires railroads to use a comprehensive approach to generating a risk based, safety case for all PTC-type systems. Following the FRA Rule 236H guidelines helps ensure that all aspects of system safety are addressed, and that a safety conclusion can be successfully drawn from the documented evidence. The FRA requirements for building a safety case are based on time-tested traditional safety analyses which are enhanced to address system-wide safety. A critical new requirement of this standard is the development of a quantitative comparative risk assessment for the system as the formal mechanism for summarizing the safety argument. The FRA Rule 236H requires the comparison of the risk of the new PTC system with the historical risk of the existing system, which will be extremely challenging for the nationwide implementation of interoperable PTC where differing operating methods may be employed on multiple railroads with differing levels of appropriate historical data to reference. These factors must be carefully considered in the risk assessment approach and in the formulation of the overall system safety case argument for this Federally-mandated implementation. The risk assessment process described in this paper is uniquely different from existing quantitative safety assessment approaches that have primarily concentrated on producing a Mean Time Between Hazardous Events (MTBHE) for the various train control components in the system. In contrast to an MTBHE method, FRA rule-compliant comparative risk assessment approaches must evaluate PTC safety in the context of the overall comprehensive system operation, considering the effects of human errors, operating rules/procedures, training practices, system maintenance, equipment failures including any time/sequence dependencies, and the movement of trains and their exposure to potentially hazardous conditions. These considerations have prompted the development of a comprehensive FRA Rule 236H-compliant risk assessment methodology that goes far beyond traditional safety analyses and is well-suited for the assessment of interoperable PTC systems.
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Holmes, Samuel, Martin Schroeder e Elton Toma. "High-Speed Passenger and Intercity Train Aerodynamic Computer Modeling". In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2147.
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Abstract With the onset of high-speed passenger train service in the United States, the Federal Railroad Administration (FRA) and railroad agencies are concerned with the aerodynamic effects these trains will have on lightweight freight equipment, such as empty double stack container cars. This paper presents the results of a research project that evaluated this interaction. In this study we conducted a series of computational fluid dynamic (CDF) calculations to characterize the aerodynamic loads on a container consist passed by a high-speed train. A train motion simulation program was used to determine resultant motion and risk of overturning or derailment of the container consist. Numerous cases were studied in which train speed and wind speed and direction were varied.
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Cocciolo, Peter P., e Bob Zeleny. "Risk Reduction Measures Applied to Horizontal Directional Drilling of a Complex Pipeline River Crossing in Canada". In 2004 International Pipeline Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ipc2004-0069.
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In August and September of 2003, Terasen Pipelines (Trans Mountain) Inc. successfully completed the Horizontal Directionally Drilled [HDD] replacement of it’s NPS 24” pipeline crossing at the Fraser River from Surrey to Coquitlam in southwestern British Columbia. The pipeline replacement was necessary to mitigate the high seismic risk from liquefaction induced lateral spreading of soils on the north and south shores of the Fraser River. The high level of urban development and the close proximity of major linear infrastructure on both sides of the river created spatial restrictions which increased the complexity and risk of the HDD crossing. Measures to reduce construction risks and limit Terasen’s exposure to claims for changed subsurface conditions, environmental damage due to frac-outs, delays, pipe and coating damage, and inability to complete the crossing, were applied. Important strategies used during planning and construction of the crossing included: proper selection of the pipeline route and laydown corridor, site specific geotechnical investigation, HDD annular pressure monitoring, HDD electronic drilling recording, and a contractor pre-qualification process. The final result was that the contractors successfully drilled and installed the 1293m long HDD crossing over a period of one month, without incident. This paper presents the challenges and solutions implemented by the project team to bring the project to its successful conclusion.
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Chrismer, Steven M. "Analysis of Lateral Track Strength for High Speed Rail". In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-82489.
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Recently the FRA has proposed a reduction in the maximum allowable net axle lateral load limit from the current 50 percent of static vertical axle load (NAL/V limit = 50%) to less than 40 percent depending, in part, on the basis of FRA’s lateral track strength model, TREDA. Such a reduction could indirectly result in limiting the maximum speed of high speed passenger trains to the equivalent of 7 inches (178 mm) cant deficiency. This paper reports on the author’s investigation of selected assumptions and calculations made in TREDA. Improvements to the model are recommended and a revised NAL/V relationship is proposed, derived from an independent analysis of the driving and resisting forces. Finally, a vehicle dynamic analysis is performed to determine how the author’s proposed revised NAL/V limit would affect 9-inch (229 mm) cant deficiency operation as the high speed rail industry is now considering.
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Llana, Patricia, e Richard Stringfellow. "Preliminary Development of Locomotive Crashworthy Components". In 2011 Joint Rail Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/jrc2011-56104.
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The Federal Railroad Administration (FRA) and the Volpe Center are continuing to evaluate new technologies for increasing the safety of passengers and operators in rail equipment. In recognition of the importance of override prevention in train-to-train collisions in which one of the vehicles is a locomotive, and in light of the success of crash energy management technologies in cab car-led passenger trains, the Volpe Center seeks to evaluate the effectiveness of components that could be integrated into the end structure of a locomotive that are specifically designed to mitigate the effects of a collision and, in particular, to prevent override of one of the lead vehicles onto the other. This paper provides preliminary results of a research program that aims to develop, fabricate and test two crashworthy components for the forward end of a locomotive: (1) a deformable anti-climber, and (2) a push-back coupler.
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Gaytan Barrera, Iveth Vianey, e Gabriela Saules Santana. "Historia de un jaguar: Reporte de caso". In 22° Congreso de la Sociedad Española de Patología Dual (SEPD) 2020. SEPD, 2020. http://dx.doi.org/10.17579/sepd2020p025.
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Objetivo: Identificar oportunamente la comorbilidad existente entre el abuso de múltiples sustancias y los trastornos mentales, ya que esta situación coloca al paciente psiquiátrico en una situación de vulnerabilidad. Describir la evolución psicopatológica y su correlación con el consumo de sustancias, que condiciona incremento en exacerbaciones clínicas, condicionando cronicidad y empeoramiento paulatino. Material y métodos: Se realizará un reporte de caso mediante el estudio retrospectivo de expediente clínico, el cual abarca 14 internamientos en Hospital Psiquiátrico Fray Bernardino Álvarez y consta de 5 tomos. Se analizará la correlación entre las exacerbaciones del trastorno psiquiátrico de base y el consumo de sustancias. Resultados y conclusiones: Se trata de paciente masculino de 38 años, el cual inicia con consumo de múltiples sustancias desde los 12 años, agregándose a los 18 años síntomas afectivos maníacos y psicóticos, ameritando desde entonces al menos 14 internamientos en Hospital Psiquiátrico Fray Bernardino Álvarez, secundario a errores de juicio y conducta graves, manía, agresividad física indiscriminada, entre otros, en cada una de las hospitalizaciones se establece correlación entre ambas patologías, identificándose plenamente como factor desencadenante de exacerbaciones del trastorno psiquiátrico de base el consumo de sustancias, lo cual aunado a nulo apego al tratamiento y pobre soporte familiar han contribuido a una evolución clínica tórpida. Tras última hospitalización, hace aproximadamente un año, actualmente se encuentra con adecuado apego a tratamiento y seguimiento médico debido a una parcial advertencia de enfermedad, aparentemente sin consumo de sustancias desde su egreso, manteniéndose asintomático, lo cual corrobora la importancia de brindar manejo multidisciplinario tanto al aspecto del consumo de sustancias, como al padecimiento psiquiátrico de base en espera de un mejor pronóstico en la vida del usuario.