Literatura científica selecionada sobre o tema "Thérapie du cerveau"
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Artigos de revistas sobre o assunto "Thérapie du cerveau"
Manus, Jean-Marie. "Adrénoleucodystrophie : thérapie génique pour le cerveau". Revue Francophone des Laboratoires 2010, n.º 421 (abril de 2010): 13. http://dx.doi.org/10.1016/s1773-035x(10)70442-1.
Texto completo da fonteMcGeer, Edith G., e Patrick L. McGeer. "Aging, Neurodegenerative Disease and the Brain". Canadian Journal on Aging / La Revue canadienne du vieillissement 16, n.º 2 (1997): 218–36. http://dx.doi.org/10.1017/s071498080001432x.
Texto completo da fonteAubry, J. F., L. Marsac, M. Pernot, B. Robert, A. L. Boch, D. Chauvet, N. Salameh et al. "Ultrasons focalisés de forte intensité pour la thérapie transcrânienne du cerveau". IRBM 31, n.º 2 (maio de 2010): 87–91. http://dx.doi.org/10.1016/j.irbm.2010.02.013.
Texto completo da fonteCollin, Ludovic. "Ouvrir le cerveau à de nouvelles thérapies". médecine/sciences 30, n.º 5 (maio de 2014): 486–88. http://dx.doi.org/10.1051/medsci/20143005004.
Texto completo da fontePoulot-Becq-Giraudon, Yiannis, Maria-Angeles Carrillo-de Sauvage e Carole Escartin. "Astrocytes réactifs et maladies cérébrales". médecine/sciences 38, n.º 10 (outubro de 2022): 786–94. http://dx.doi.org/10.1051/medsci/2022104.
Texto completo da fonteCrespel, A., M. Baldy-Moulinier e M. Lerner Natoli. "La neurogénèse dans le cerveau adulte : de l’effondrement des dogmes vers de nouvelles thérapies ?" Revue Neurologique 160, n.º 12 (dezembro de 2004): 1150–58. http://dx.doi.org/10.1016/s0035-3787(04)71159-5.
Texto completo da fonteVAL-LAILLET, D., M. C. MEUNIER-SALAÜN e C. CLOUARD. "Neurobiologie du comportement alimentaire : le modèle porcin en neurosciences comportementales appliquées à l’alimentation et à la santé humaines". INRA Productions Animales 29, n.º 4 (13 de dezembro de 2019): 279–90. http://dx.doi.org/10.20870/productions-animales.2016.29.4.2969.
Texto completo da fonteGuilloux, Jean-Philippe, Thi Mai Loan Nguyen e Alain M. Gardier. "La kétamine : un neuropsychotrope au mécanisme d’action innovant". Biologie Aujourd’hui 217, n.º 3-4 (2023): 133–44. http://dx.doi.org/10.1051/jbio/2023026.
Texto completo da fonteTeses / dissertações sobre o assunto "Thérapie du cerveau"
Marsac, Laurent. "Focalisation utrasonore adaptative et application à la thérapie du cerveau". Paris 7, 2013. http://www.theses.fr/2013PA077106.
Texto completo da fonteThe aim of this thesis is to optimize transcranial ultrasound focusing for brain therapy at 1 MHz. Tissues are heated in a non invasive way by focused ultrasound using a spherical probe. Distortion of the wavefront induced by the skull is compensated. Treatments are MR-guided in order to measure the temperature rise at focus. In vitro ultrasound measurements allowed to measure the phase and amplitude aberration on different skulls. Aberration correction based on CT scan imagine of the skull and numerical simulations are optimised and compared. The best method is applied to ex vivo human heads for validation of the accuracy. Skull aberrations are corrected by an adaptative focusing method based on the estimation of the acoustic intensity at focus. Measurement is done thanks to the displacement of the tissue induced by the acoustic radiation pressure. Measurement done by an MR-ARFI IRM sequence and validated in phantoms and cadaver heads and confirms a better focusing. The blood brain barrier (BBB) was opened on 2 animals. This is done by focusing after injection of microbubbles in blood. Local BBB opening and its closing after 24h are verified. These first applications at 1 MHz allow to prepare future applications on patients
Aubry, Jean-François. "Focalisation ultrasonore adaptative : application à l'imagerie et à la thérapie du cerveau". Paris 7, 2002. http://www.theses.fr/2002PA077012.
Texto completo da fonteChodan, Desmaris Nathalie. "Thérapie génique des atteintes neurologiques dans les mucopolysaccharidoses". Paris 7, 2004. http://www.theses.fr/2004PA077039.
Texto completo da fonteTanter, Mickael. "Application du retournement temporel à l'hyperthermie ultrasonore du cerveau". Paris 7, 1999. https://pastel.archives-ouvertes.fr/pastel-00650031.
Texto completo da fonteMartina, Marie Sophie. "Conception de magnétoliposomes furtifs pour le diagnostic et la thérapie anti-cancéreuse". Paris 11, 2006. http://www.theses.fr/2006PA114831.
Texto completo da fonteA novel hybrid nanosystem, resulting from the encapsulation of iron oxid nanoparticles into stercally stabilised phospholipidic vesicles, has been realised and characterised. These socalled magnetoliposomes, revealed as excellent MRI contrast agents, could be guided towards a tumor tissue or a cerebral hemisphere thanks to an external magnetic gradient
Guttin, Audrey. "Développement d’une bithérapie antitumorale basée sur une approche théranostique : applications aux cancers du cerveau et de la vessie". Thesis, Paris, EPHE, 2016. http://www.theses.fr/2016EPHE3018/document.
Texto completo da fonteSolid malignant tumors have molecular characteristics that clearly distinguish them from healthy tissue. The project is to develop a new therapeutic strategy based on these molecular characteristics. We set up a new therapeutic approach so as to customize treatment by connecting it directly to the diagnosis of the tumor (theranostic approach).Brain tumours and bladder tumours are two examples of particularly aggressive solid tumours. These two types of tumors are classified into several subgroups that have their own molecular profiles. The microRNAs (miR) are molecules naturally synthesized by cells. These molecules may have a role of oncogene or tumour suppressors whose expression is strongly deregulated in tumours. So the assessment of the expression levels of few microRNA allows the distinction of gliomas of high grade compared to low grade.To set up the new therapy we needed to modulate the expression of microRNAs deregulated in tumors. The proposed approach was to counter the expression of oncogenic microRNAs overexpressed using an antimicroARN (antimiR). This type of molecule is chemically similar to the naturally occurring RNA molecules in the cells. For a better efficiency of this new therapeutic strategy, we tried to optimize the transport of the antimiR to increase the therapeutic effect. To vectorize the therapeitic antimiR to the heart of the tumor, we envisioned to chemically combine the antimiR to a cell-penetrating antitumoral compound. Chalcones derivatives which are hydrophobic have this capability. A combination of the two molecules (antimicroARN and chalcone) was evaluated and the results appeared promising
Giguère-Rancourt, Ariane. "Augmentation de la captation cérébrale du glucose par thérapie génique comme alternative thérapeutique dans la maladie d'Alzheimer : essais préliminaires". Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26443.
Texto completo da fonteImpaired brain glucose metabolism is known to be one of the best predictors of cognitive decline in patients with Alzheimer’s disease (AD). A decrease in glucose transporter 1 (GLUT1) in the brain capillary endothelial cells (BCECs) of the blood-brain barrier (BBB) is observed in AD patients and animal models and might contribute to impaired brain glucose uptake in the disease. The main objective of the present work was to upregulate GLUT1 in the BCECs with a targeted delivery approach using plasmids encoding for GLUT1. Six plasmids were assembled and transfected in two cell lines. GLUT1 activity was assessed with a fluorescent glucose analog. Two plasmids were then encapsulated within an immunoliposome formulation and injected to Balb/c mice. We have generated well-characterized GLUT1-expressing plasmids for future work to confirm GLUT1 as a potential therapeutic target for AD.
Paris-Robidas, Sarah. "Caractérisation de vecteurs ciblant le récepteur de la transferrine : ciblage des cellules endothéliales du cerveau". Doctoral thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/30323.
Texto completo da fonteThe increase in life expectancy leads to a direct expansion of the aging population. This expansion further increases the burden of neurodegenerative diseases. The development of new drugs to treat brain pathologies is greatly hindered by the presence of a physiological barrier, the blood-brain barrier (BBB), protecting the brain homoeostasis. However, a high number of specific transporters are located on endothelial cells forming the BBB and could be the target of brain-drug delivery allowing significant cerebral accumulation of many therapeutic compounds. To study the potential of monoclonal antibodies (mAb) targeting the transferrin receptor (TfR) in the context of a non-invasive gene therapy strategy, we foremost studied the cerebral distribution of the mAb Ri7. We first observed retention in the brain of the mAb. However, fluorescence microscopy analysis revealed that the distribution of Ri7 was confined to cerebral vasculature. Thereafter, by conjugating Ri7 to quantum dots (Qdot), we performed experiments to characterize the subcellular distribution of the mAb. Our transmission electron microscopy analyses showed that Ri7-Qdots were massively internalized within brain capillary endothelial cells (BCECs) and that the TfR-targeted Qdots were in small vesicles, tubular structures and multivesicular bodies. We thus identified BCECs as a potential target for the treatment of endothelial pathology of neurodegenerative diseases. Finally, we investigated the potential of two nanoformulations to delivery nucleic acids to BCECs. Our data demonstrated the capacity of polyionic complex micelles and immunliposomes to deliver a large number of nucleic acids to BCECs. Overall, our study opens the door for a novel therapeutic approach based on brain endothelial cells drug delivery.
Posvandzic, Alma. "Développement d'un vecteur lentiviral spécifique aux macrophages cérébraux activés pour la thérapie génique appliquée à des maladies du système nerveux". Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/25000/25000.pdf.
Texto completo da fonteMagdeleine, Christophe. "La Toxoplasmose cérébrale au cours du SIDA à la Martinique : étude de dossiers de 1985 à 1992". Paris 11, 1994. http://www.theses.fr/1994PA115049.
Texto completo da fonteLivros sobre o assunto "Thérapie du cerveau"
Mortier, Janine. Réactiver les fonctions naturelles du cerveau: Le doctor Vittoz, un précurseur : la thérapie Vittoz. Paris: Téqui, 2005.
Encontre o texto completo da fonteCapacchione, Lucia. Le pouvoir de votre autre main: Comment accéder à la sagesse de notre cerveau droit. Orsay: Médicis-Entrelacs, 1997.
Encontre o texto completo da fonteQuyen, Michel Le Van. Les pouvoirs de l'esprit: Transformer son cerveau, c'est possible! Paris: Flammarion, 2015.
Encontre o texto completo da fonteLebigre, Cédric. Parfois 7 Mots Suffisent: Ces Trucs Utiles Au Cerveau Que l'on Révèle Uniquement en Thérapie. Independently Published, 2020.
Encontre o texto completo da fonteLebigre, Cédric. Parfois 7 Mots Suffisent: Ces Trucs Utiles Au Cerveau Que l'on Révèle Uniquement en Thérapie. Independently Published, 2020.
Encontre o texto completo da fonteMatuten, James. RecÂblez Votre Cerveau: Comment Sortir de la dÉPRESSION, Surmonter les TROUBLES d'ANXIÉTÉ et les CRISES de PANIQUE Grâce Aux TECHNIQUES de Thérapie Cognitive et Comportementale. Independently Published, 2022.
Encontre o texto completo da fonteTodd, David, e Stephen Weatherhead. Narrative Approaches to Brain Injury. Karnac Books, 2013.
Encontre o texto completo da fonteTodd, David, e Stephen Weatherhead. Narrative Approaches to Brain Injury. Taylor & Francis Group, 2018.
Encontre o texto completo da fonte(Editor), Stuart C. Yudofsky, Jonathan M. Silver (Editor) e Thomas W. McAllister (Editor), eds. Textbook of Traumatic Brain Injury. American Psychiatric Publishing, Inc., 2004.
Encontre o texto completo da fonteArciniegas, David B., Thomas W. McAllister e Jonathan M. Silver. Textbook of Traumatic Brain Injury. American Psychiatric Association Publishing, 2018.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Thérapie du cerveau"
Roche, Jean. "Vieillissement cognitif : de la plainte à la prise en charge". In Vieillissement cognitif : de la plainte à la prise en charge, 49–64. In Press, 2021. http://dx.doi.org/10.3917/pres.bacle.2021.01.0050.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Thérapie du cerveau"
Dubuc, A., P. Monsarrat, S. Laurencin-Dalicieux, F. Virard, J. P. Sarrette, N. Merbahi e S. Cousty. "Application du plasma atmosphérique froid en oncologie : une revue systématique". In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206603018.
Texto completo da fonte