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Artigos de revistas sobre o assunto "Theoretical population genetics":

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Ewens, W. J. "Theoretical population genetics". Genome 31, n.º 2 (15 de janeiro de 1989): 1088–89. http://dx.doi.org/10.1139/g89-188.

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Chakraborty, Ranajit. "Theoretical Population Genetics". Trends in Ecology & Evolution 6, n.º 2 (fevereiro de 1991): 68. http://dx.doi.org/10.1016/0169-5347(91)90132-h.

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Wakeley, John. "The Limits of Theoretical Population Genetics". Genetics 169, n.º 1 (1 de janeiro de 2005): 1–7. http://dx.doi.org/10.1093/genetics/169.1.1.

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Couvet, D. "Introduction to theoretical population genetics". Trends in Ecology & Evolution 8, n.º 5 (maio de 1993): 192. http://dx.doi.org/10.1016/0169-5347(93)90152-f.

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WAKELEY, J. "John Wakeley discusses theoretical population genetics". Biosilico 1, n.º 3 (julho de 2003): 84–85. http://dx.doi.org/10.1016/s1478-5382(03)02344-8.

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Sarkar, Sahotra. "The Origins of Theoretical Population Genetics". Endeavour 26, n.º 2 (junho de 2002): 77. http://dx.doi.org/10.1016/s0160-9327(02)01414-x.

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Al Ghafri, Mataab K. "The theoretical approach to population genetics". Ology: Reviews in Applied Sciences 1 (3 de outubro de 2018): 10–11. http://dx.doi.org/10.14297/ras.v1i1.3.

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Kretschmer, Hildrun, e B. M. Gupta. "Collaboration patterns in theoretical population genetics". Scientometrics 43, n.º 3 (novembro de 1998): 455–62. http://dx.doi.org/10.1007/bf02457409.

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Gupta, B. M., e C. R. Karisiddappa. "Collaboration in theoretical population genetics speciality". Scientometrics 42, n.º 3 (outubro de 1998): 349–76. http://dx.doi.org/10.1007/bf02458377.

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Charlesworth, Brian. "The Origins of Theoretical Population Genetics: How population and quantitative genetics began". Trends in Genetics 18, n.º 6 (junho de 2002): 324–25. http://dx.doi.org/10.1016/s0168-9525(02)02680-x.

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Teses / dissertações sobre o assunto "Theoretical population genetics":

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Lundy, Ian J. "Theoretical population genetics of spatially structured populations /". Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phl962.pdf.

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Affenzeller, Michael. "Population genetics and evolutionary computation : theoretical and practical aspects /". Linz : Trauner, 2005. http://www.gbv.de/dms/ilmenau/toc/490631479affen.PDF.

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Levin, Alex Ph D. (Alexander) Massachusetts Institute of Technology. "Graphs, matrices, and populations : linear algebraic techniques in theoretical computer science and population genetics". Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83695.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Department of Mathematics, 2013.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 149-155).
In this thesis, we present several algorithmic results for problems in spectral graph theory and computational biology. The first part concerns the problem of spectral sparsification. It is known that every dense graph can be approximated in a strong sense by a sparse subgraph, known as a spectral sparsifier of the graph. Furthermore, researchers have recently developed efficient algorithms for computing such approximations. We show how to make these algorithms faster, and also give a substantial improvement in space efficiency. Since sparsification is an important first step in speeding up approximation algorithms for many graph problems, our results have numerous applications. In the second part of the thesis, we consider the problem of inferring human population history from genetic data. We give an efficient and principled algorithm for using single nucleotide polymorphism (SNP) data to infer admixture history of various populations, and apply it to show that Europeans have evidence of mixture with ancient Siberians. Finally, we turn to the problem of RNA secondary structure design. In this problem, we want to find RNA sequences that fold to a given secondary structure. We propose a novel global sampling approach, based on the recently developed RNAmutants algorithm, and show that it has numerous desirable properties when compared to existing solutions. Our method can prove useful for developing the next generation of RNA design algorithms.
by Alex Levin.
Ph.D.
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Söderberg, Jonas. "Surviving the ratchet : Modelling deleterious mutations in asexual populations". Doctoral thesis, Uppsala universitet, Molekylär evolution, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157897.

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One of the most unforgiving processes in nature is that of Muller's ratchet, a seemingly irreversible accumulation of deleterious mutations that all organisms have to deal with or face extinction. The most obvious way to avoid fitness collapse is recombination, though asexual populations usually do not have the luxury of recombining freely.  With the aid of computational and mathematical models, we have studied other situations where this threat is averted and the organism can survive the ratchet. The results show that a ratchet where all mutations have the same deleterious fitness effect is very effectively stalled for large effects. However, if mutations are allowed to have a broad range of effects, the fitness-loss rate can be substantial even with the same mean effect as the one-type ratchet, but we have  identified parameter regions where even the broad-range effects are effectively stopped. The fitness-loss from a ratchet is very sensitive to the mutation rate and a mutation that increases the mutation rate (mutator) can easily start an otherwise stalled ratchet. Large effect mutators are heavily counter-selected, but smaller mutators can spread in the population. They can be stopped by reversals (antimutators), but even if the mutation rate is equilibrated in this way, there will be large fluctuations in mutation rate and even larger in the fitness-loss rate due to the feedback amplification in their coupling.    Another way of preventing the ratchet is by reversal of the deleterious mutations themselves through back-mutations or compensatory mutations. The rate required to stop the ratchet using only back-mutations before the fitness collapses is very large. A detailed comparison between the deleterious mutations in the ratchet and in a sexual population was made and the difference was found to be greatest for large populations with large genomes. There are obviously many ways to survive the ratchet, but even more ways to drive a species to extinction by enhancing and speeding up the ratchet. By modelling and testing the ratchet for numerous different situations, we show the effects of some of these threats and benefits.
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Bergek, Sara. "Population divergence at small spatial scales : – theoretical and empirical investigations in perch". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107223.

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Lesaffre, Thomas. "Contribution à une théorie physiologique et génétique de l’évolution végétale : fardeau génétique, systèmes de reproduction et évolution du taux de mutation dans les populations structurées en classes". Electronic Thesis or Diss., Université de Lille (2018-2021), 2021. http://www.theses.fr/2021LILUR014.

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Chez les Angiospermes, il existe une forte association entre histoire de vie et système de reproduction. En effet, la plupart des espèces autofécondantes sont annuelles alors que la majorité des espèces pérennes sont allofécondantes. Cette association est le point de départ du travail réalisé dans cette thèse. Dans le premier chapitre, je m'intéresse à la coévolution entre longévité et autofécondation sous l'hypothèse que la dépression de consanguinité affecte la survie des individus entre les saisons de floraison et qu'elle est fixée par un paramètre. Sous ces hypothèses, l'évolution de l'autofécondation est d'autant plus empêchée que la longévité de l'espèce considérée augmente, car la dépression de consanguinité subie à l'échelle de l'existence complète des individus devient plus forte. Lorsqu'elle se produit néanmoins, elle induit une diminution de la longévité à l'équilibre évolutif. Ces résultats sont en accord avec le patron empirique observé. Dans le chapitre deux, je lève l'hypothèse d'une dépression de consanguinité fixée par un paramètre en donnant une base génétique explicite à cette dernière. Je montre que des mutations affectant la survie, loin de générer une augmentation de la dépression de consanguinité avec la longévité, aboutissent à une diminution de cette dernière. Partant du constat qu'une augmentation de la dépression de consanguinité est pourtant bien observée chez les espèces pérennes, j'explore deux hypothèses pour expliquer cette augmentation. Dans le chapitre deux, j'étudie l'idée plus générale selon laquelle des variations des effets sélectifs des mutations avec la longévité, dont des mutations affectant la survie ne sont qu'un cas particulier, pourraient générer ce patron. Dans le chapitre trois, je m'intéresse aux conséquences de l'accumulation de mutations somatiques pour l'évolution du taux de mutation et la dépression de consanguinité résultante chez les plantes. Le chapitre quatre est quant à lui consacré à une évaluation théorique des méthodes d'estimation de la dépression de consanguinité. Je termine ce manuscrit en proposant des pistes pour l'élaboration d'une théorie physiologique et génétique de l'évolution végétale
In Angiosperms, there exists a strong association between life-history and mating system. Indeed, most predominantly selfing species are annual while the majority of perennials are outcrossers. This association is the starting point of the work presented in this thesis. In the first chapter, I study the joint evolution of lifespan and selfing assuming that inbreeding depression affects survival between flowering seasons and is fixed by a parameter. Under these assumptions, lifetime inbreeding depression increases as lifespan increases therefore preventing the evolution of self-fertilisation in a wider parameter range. When it occurs, it induces the evolution of shorter lifespans. These results are in agreement with the empirically observed pattern. In chapter two, I relax the assumption that inbreeding depression is fixed by a parameter, by assuming an explicit genetic basis. Far from generating higher inbreeding depression in more long-lived species, deleterious mutations affecting survival result in a decrease of inbreeding depression with longevity at mutation-selection equilibrium. Yet, increased inbreeding depression is empirically observed in long-lived species. In the following chapters, I explore two hypotheses to explain this increase. In chapter two, I study the more general idea that variations in the fitness effects of mutations with longevity, of which mutations affecting survival are a mere special case, may generate increased inbreeding depression in longer-lived species. In chapter three, I model the consequences of inheritable somatic mutations accumulating during growth for the evolution of the mutation rate and the resulting inbreeding depression in plants. As for chapter four, it is devoted to a theoretical evaluation of indirect inbreeding depression estimation methods. I end this manuscrit by proposing leads and ideas for the development of a physiological and genetic theory of plant evolution
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Wong, Hor Yan. "Some theoretical aspects of self-incompatibility systems in plants". Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249167.

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Taylor, Jesse Earl. "Host structuring of parasite populations: Some theoretical and computational studies". Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/289991.

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Because the ecological and the genetic interactions occurring between parasites belonging to different infections are constrained by the physical discreteness of the hosts, the host-parasite association imparts a spatial structure to the populations of parasitic microorganisms. Equating infections with demes or islands, the parasite population can be described by a variant of Wright's island model, in which recovery and infection correspond to extinction and colonization and superinfection corresponds to migration. Here we investigate some of the population genetic consequences of host structure using a combination of theoretical and computational methods. In our first study, we introduce a measure-valued process as a model for the evolution of an age-structured parasite metapopulation and show how to approximate this process using the measure flow generated by a jump-diffusion. We characterize the invariant measures and corresponding jump distributions for the approximation and apply these methods to an example involving a single locus subject to mutation, selection, and genetic drift within hosts and to bottlenecks and bias during transmission. When intrahost selection and transmission bias act discordantly, it is shown that the invariant measure and the jump distribution can differ substantially. We discuss the implications of such discordance for vaccine target selection and review the evidence for biased transmission of HIV-1. In our second study, we use a branching Fisher-Wright process to characterize diversity in an exponentially expanding epidemic. We derive a renewal equation for the persistence probability of the branching diffusion and show that with sufficiently rapid branching a set of k neutral alleles can persist indefinitely with positive probability. In the last study, we exploit the relationship between population recombination rates and superinfection rates to quantify intra-subtype superinfection by HIV-1 in populations from Africa, China, Thailand, Trinidad and Tobago, and the US. Comparison of the population recombination rates estimated for these data sets with those found for data sets simulated using a structured coalescent process representing HIV-1 evolution within an epidemiologically closed population indicates that per-sequence superinfection rates are probably not less than 15% of the corresponding infection rates.
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Le, Vève Audrey. "Balancing selection, genetic load and dominance between self-incompatibility alleles in Arabidopsis : an empirical and theoretical study of this ménage à trois". Electronic Thesis or Diss., Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILR006.

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L'auto-incompatibilité sporophytique est un système génétique empêchant l'autofécondation par reconnaissance du soi. Chez de nombreuses espèces, ce système est contrôlé par un locus unique, le locus S, composé de deux gènes liés codant pour les protéines de reconnaissance du pistil et du pollen. Le locus d'auto-incompatibilité est un cas classique d'une forme particulière de sélection équilibrante appelée sélection fréquence dépendante négative. Cette forme de sélection est censée provoquer une accumulation de polymorphisme dans les régions flanquantes du locus S, y compris des mutations délétères. Chez les Brassicacea, ce système présente une hiérarchie de dominance linéaire entre les allèles S. Ce réseau de dominance est contrôlé par des interactions entre les allèles S. Ce réseau de dominance est contrôlé par des interactions entre les petits ARN liés aux allèles S dominants et leurs séquences cibles sur les allèles récessifs du gène contrôlant les spécificités polliniques SCR. Il est prédit que le niveau de dominance a un effet sur l'accumulation de polymorphismes dans les régions immédiatement liées au locus S, avec une accumulation plus importante de la charge génétique par les allèles S dominants que par les allèles S récessifs.Dans mon projet de thèse, j'ai d'abord étudié l'effet de la sélection équilibrante au locus S sur le polymorphisme dans les régions flanquantes afin de déterminer l'ampleur du pic de polymorphisme et de caractériser ses propriétés moléculaires. J'ai utilisé les données de reséquençage du génome entier de plusieurs populations d'A. halleri et d'A. lyrata pour déterminer spécifiquement la distance chromosomique jusqu'à laquelle l'effet du locus S peut encore être observé. J'ai observé une augmentation du polymorphisme dans les premiers 25kb autour du locus S, principalement expliquée par une augmentation de la proportion de sites polymorphes.J'ai ensuite testé si la dominance des allèles S influence la charge génétique qu'ils accumulent. J'ai combiné une approche génomique utilisant des trios parents-descendant pour mettre en phase les haplotypes liés au locus S et comparer le nombre de mutations délétères liées aux allèles S dominants vs récessifs, avec une approche phénotypique pour mesurer expérimentalement l'impact de cette charge génétique protégée. J'ai démontré que la dominance favorise des profils contrastés de la charge génétique entre les allèles S récessifs et dominants.Enfin, j'ai utilisé une approche de modélisation basée sur des simulations stochastiques pour prédire l'évolution du réseau de dominance entre les allèles S, en prenant explicitement en compte les interactions entre les petits ARN et leurs cibles SCR. Mes résultats montrent que les mutations ont des probabilités de fixation différentes selon qu'elles se produisent sur des allèles S dominants ou récessifs, et aussi selon qu'elles touchent le locus producteur de petits ARN ou ses sites cibles. La distribution de la charge génétique abritée entre les allèles S dominants et récessifs est également un déterminant important de l'évolution du réseau de dominance
Sporophytic self-incompatibility is a genetic system preventing self-fertilization by self-recognition. In many species, this system is controlled by a single locus, the S-locus, composed of two linked genes coding for the pistil and pollen recognition proteins. The self-incompatibility locus is a classical case of a particular form of balancing selection called negative frequency dependent selection. This form of selection is predicted to cause an accumulation of polymorphism in the flanking regions of the S-locus, including sheltered deleterious mutations. In the Brassicacea, this system exhibits a linear dominance hierarchy between S-alleles. This dominance network is controlled by interactions between small RNAs linked to dominant S-alleles and their target sequences on recessive alleles of the gene controlling the pollen specificities SCR. The dominance level is predicted to have an effect on the accumulation of polymorphisms in regions immediately linked to the S-locus, with a higher accumulation of the genetic load sheltered by dominant S-alleles than by recessive S-alleles.In my PhD project, I first studied the effect of balancing selection at the S-locus on polymorphism in the flanking regions in order to determine the magnitude of the peak of polymorphism and to characterize its molecular properties. I used whole genome resequencing data from several populations of A. halleri and A. lyrata to specifically determine the chromosomal distance up to which the effect of the S-locus can still be observed. I observed an increase of polymorphism in the first 25kb around the S-locus, mainly explained by an increase of the proportion of polymorphic sites.I then tested if dominance of the S-alleles influences the genetic load they accumulate. I combined a genomic approach using parent-offspring trios to phase haplotypes and compare the number of deleterious mutations linked to dominant vs. recessive S-alleles, with a phenotypic approach to experimentally measure the severity of the load. I demonstrated that dominance promotes contrasted profiles of the genetic load between the recessive and the dominant S-alleles.Finally, I used a modeling approach based on stochastic simulations to predict the evolution of the dominance network between S-alleles, taking interactions between small RNAs and their SCR targets explicitly into account. My results show that mutations have different fixation probabilities according to whether they occur on dominant vs. recessive S-alleles, and also whether they hit the small RNA producing locus or its target sites. The distribution of the sheltered genetic load between dominant and recessive S-alleles is also an important determinant of the evolution of the dominance network
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Reichel, Katja. "Effets de la reproduction partiellement asexuée sur la dynamique des fréquences génotypiques en populations majoritairement diploïdes". Thesis, Rennes, Agrocampus Ouest, 2015. http://www.theses.fr/2015NSARC123/document.

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Les systèmes reproducteurs déterminent comment le matériel génétique est transmis d’une génération à la suivante […]. Les espèces qui combinent de la reproduction sexuée et asexuée/clonale sont très répandues [… mais] l’effet de leur système reproducteur sur leur évolution reste énigmatique et discuté.L’objectif de cette thèse est de modéliser la dynamique des fréquences génotypiques d’une population avec une combinaison de reproduction sexuée et/ou clonale dans des cycles de vie principalement diploïdes [. … Un] modèle du type chaine de Markov avec temps et états discrets sert de base mathématique pour décrire [leurs] changements […] au cours du temps.Les résultats montrent que la reproduction partiellement asexuée peut en effet modifier la dynamique de la diversité génomique par rapport à une reproduction strictement sexuée ou strictement asexuée. […] L’histoire démographique a un rôle important pour les organismes partiellement clonaux et doit être prise en compte dans toute analyse […].Cette thèse fait des recommandations pour la collecte des données et une hypothèse de base pour l’interprétation des données de génétique/génomique […]. Ces résultats ont des retombées dans plusieurs domaines, allant de la recherche fondamentale […] à des applications en agriculture […], pêche […] et protection de la nature […]
Reproductive systems determine how genetic material is passed from one generation to the next, making them an important factor for evolution. Organisms that combine sexual and asexual/clonal reproduction are very widespread [… yet] the effects of their reproductive system on their evolution are still controversial and poorly understood.The aim of this thesis was to model the dynamics of genotype frequencies under combined sexual/clonal reproduction in dominantly diploid life cycles [. … A] state and time discrete Markov chain model served as the mathematical basis to describe [their] changes […] through time.The results demonstrate that partial clonality may indeed change the dynamics of genomic diversity compared to either exclusively sexual or exclusively clonal populations. […] Time has a crucial role in partially clonal populations and needs to be taken into account in any analysis of their genomic diversity.This thesis provides recommendations for data collection and a null hypothesis for the interpretation of population genetic/genomic data […]. Moreover, it includes new methods for the analysis of genotype-based population genetic Markov chain models. These results have a high potential relevance in several areas, ranging from basic research […] to applications in agriculture […], fisheries […] and nature conservation […]

Livros sobre o assunto "Theoretical population genetics":

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Gale, J. S. Theoretical Population Genetics. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6.

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Gale, J. S. Theoretical population genetics. Boston: Unwin Hyman, 1990.

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Gale, J. S. Theoretical population genetics. London: Unwin Hyman, 1990.

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4

Nagylaki, Thomas. Introduction to Theoretical Population Genetics. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76214-7.

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Nagylaki, Thomas. Introduction to theoretical population genetics. Berlin: Springer-Verlag, 1992.

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Christiansen, Freddy B. Population genetics of multiple loci. Chichester: Wiley, 2000.

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Karlin, Samuel. Theoretical studies on sex ratio evolution. Princeton, N.J: Princeton University Press, 1986.

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Etheridge, Alison. Some Mathematical Models from Population Genetics: École d'Été de Probabilités de Saint-Flour XXXIX-2009. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2011.

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9

Wakeley, John. Coalescent theory: An introduction. Greenwood Village, Colo: Roberts & Co. Publishers, 2009.

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Wakeley, John. Coalescent theory: An introduction. Greenwood Village, Colo: Roberts & Company Publishers, 2008.

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Capítulos de livros sobre o assunto "Theoretical population genetics":

1

Gale, J. S. "Introduction". In Theoretical Population Genetics, 1–11. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_1.

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Gale, J. S. "Diffusion methods". In Theoretical Population Genetics, 347–96. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_10.

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Gale, J. S. "General comments and conclusions". In Theoretical Population Genetics, 397–402. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_11.

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Gale, J. S. "Wright-Fisher, Moran and other models". In Theoretical Population Genetics, 12–55. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_2.

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Gale, J. S. "On the description of changes in allele frequency". In Theoretical Population Genetics, 56–105. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_3.

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Gale, J. S. "Survival of new mutations: branching processes". In Theoretical Population Genetics, 106–51. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_4.

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Gale, J. S. "Probability of fixation: the more general case". In Theoretical Population Genetics, 152–93. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_5.

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Gale, J. S. "Some notes on continuous approximations". In Theoretical Population Genetics, 194–212. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_6.

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Gale, J. S. "Mean sojourn, absorption and fixation times". In Theoretical Population Genetics, 213–76. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_7.

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Gale, J. S. "Introduction to probability distributions: probability flux". In Theoretical Population Genetics, 277–302. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0387-6_8.

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Trabalhos de conferências sobre o assunto "Theoretical population genetics":

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Przewozniczek, Michal W., Piotr Dziurzanski, Shuai Zhao e Leandro S. Indrusiak. "Multi-objective parameter-less population pyramid in solving the real-world and theoretical problems". In GECCO '21: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3449726.3462724.

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Dong, Xiaomeng, Zulong Zhao, Daoyong Yang e Na Jia. "Quantification of Gas Exsolution Dynamics for CO2/CH4-Heavy Oil Systems with Population Balance Equations". In SPE Canadian Energy Technology Conference and Exhibition. SPE, 2024. http://dx.doi.org/10.2118/218070-ms.

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Abstract Although foamy oil phenomenon has been considered as the key factor that dominates heavy oil recovery, the existing models cannot be used to accurately quantify gas exsolution dynamics in foamy oil under various conditions due to the inherent physics and complex flow behaviour. In this study, experimental and theoretical techniques have been developed to quantify gas exsolution dynamics of CO2/CH4-heavy oil systems while considering gas bubble nucleation mobilization, and binary coalescence. Experimentally, constant composition expansion (CCE) tests were performed with a sealed PVT apparatus for the CO2/CH4-heavy oil systems to induce foamy oil behaviour by gradually depleting pressure at a constant temperature, during which the pressures and volume changes were monitored and recorded continuously. Theoretically, the Fick's law, equation of state, classical nucleation theory, and population balance equation have been integrated to describe the gas exsolution dynamics, during which gas bubbles are discretized with the fixed-pivot technique. The gas bubble number and size distribution in the induced foamy oil can then be determined once the deviations between the measured and calculated parameters, including liquid volume and pseudo-bubble point pressure, have been minimized with the genetic algorithm. For both CO2- and CH4-heavy oil systems, not only can a reducing pressure depletion rate or an increasing temperature result in a higher pseudo-bubblepoint pressure, but also gas bubble growth is strongly dependent on both temperature and diffusion of a gas component in heavy oil, while increasing the solvent concentration in the heavy oil tends to hinder the gas bubble nucleation and mitigation due to the higher pressure set for the experiments. During the generation of foamy oil, a higher temperature reduces heavy oil viscosity to accelerate the diffusion process, positively contributing to the gas bubble nucleation, binary coalescence, and bubble mobilization, respectively. Compared with CO2, CH4 induces a stronger and more stable foamy oil, illustrating that, at a lower temperature, foamy oil is more stable with more dispersed gas bubbles. In this study, the newly developed theoretical techniques are able to reproduce gas exsolution dynamics at the bubble level, allowing us to seamlessly integrate them with any reservoir simulators to not only accurately characterize foamy oil behaviour, but also evaluate the associated recovery performance.
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TRUKHACHEV, Vladimir, Sergey OLEYNIK e Nikolay ZLYDNEV. "FEATURES OF THE KARYOTYPE OF NORTH CAUCASUS AYRSHIRE DAIRY CATTLE POPULATION: DEFECTS IN REPRODUCTIVE FUNCTIONS". In RURAL DEVELOPMENT. Aleksandras Stulginskis University, 2018. http://dx.doi.org/10.15544/rd.2017.141.

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One of the ways of improving the genotypes of dairy cattle in Russia is to increase the proportion of the Ayrshire breed, which can be justly claimed to be one of the best dairy breeds in the world. However, due to the prevalence of large-scale breeding technologies, which involves the use of a limited contingent of dairy cattle bulls, including but not limited to the Ayrshire breed, the emergence of new-born calves with various anomalies, including chromosomal, which commonly have a hereditary basis attributable to gene mutations have been observed. Given that the bulk of these anomalies are acquired by recessive inheritance, they may not always manifest themselves in the phenotype and thus represent a hidden genetic load. In recent years, the significance of cytogenetic analysis and karyotyping is becoming increasingly important, not only when considering the theoretical assumptions, but also when solving applied problems aimed at preventing damage to agricultural production. This article presents the results of the cytogenetic analysis of Ayrshire cattle affected by reproductive problems. The following has been established: an absence of changes in the diploid set of the investigated dairy cattle (2n = 60); the presence of aberrant cells, whose frequency of occurrence amounted to 3.6% in the population of 440 head (number of aberrations per aberrant cell researched – 0.036 / 1.0); the absence of reciprocal translocations in the karyotype of the investigated population. It is suggested that the existing Ayrshire sires Hannulan Yaskiyri, Riihiviidan Urho Errant, O.R.Lihting and their descendants do not have a genetic load of chromosomal abnormalities.
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Tian, Hao, e James D. Van de Ven. "Geometric Optimization of a Hydraulic Motor Rotary Valve". In ASME/BATH 2013 Symposium on Fluid Power and Motion Control. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fpmc2013-4426.

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The performance of a hydraulic motor is strongly influenced by the timing, leakage, and friction of the valves connecting to the pressure and tank ports. For the application of a linkage-based hydraulic piston motor, a novel clearance sealed cylindrical rotary valve is introduced. A model of the cylinder pressure dynamics is formulated from the bulk modulus definition and solved using a variable-step Runge-Kutta stiff solver. Energy loss equations are developed and used to aid the creation of objective functions. A geometric optimization of the motoring efficiency is conducted based on coupled relationships: including throttling across the transitioning and fully open valve ports, viscous friction, and leakage, but excluding piston related losses. A simple genetic algorithm is used to obtain the optimized geometry, and a theoretical system efficiency greater than 97% is achieved. A multi-objective sub-population genetic algorithm is then used to generate Pareto Optimal solutions for different combinations of efficiency and output power. A sensitivity study of the valve timing and rotational frequency shows the starting angle of the pressure port and the width of the rotor orifice dominate the performance while the system frequency has negligible effects.
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Cuciumita, Cleopatra F., Valeriu A. Vilag, Valentin Silivestru e Ionut Porumbel. "Genetic Algorithm for Gas Turbine Blading Design". In ASME 2011 Turbo Expo: Turbine Technical Conference and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/gt2011-46171.

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Designing a gas turbine from scratch has always been an extremely laborious task in terms of obtaining the desired power output and efficiency. Theoretical prediction of the performances of a gas turbine has proven in time to be a compromise between accuracy and simplicity of the calculus. Methods such as the Smith chart are very easy to apply, but to make an exact prediction of the flow in a turbine would lead to an almost infinite number of variables to be considered. A quite precise method of determining total-loss coefficients for a gas turbine, based on a large number of turbine tests, was developed by D.G. Ainley and G.C.R. Mathieson, with an error of the calculated efficiency within 2%. The accuracy of the method has been validated by Computational Fluid Dynamics simulations, included in the paper. Even if it is not a novel approach, the method provides accurate numerical results, and thus it is still widely used in turbine blade design. Its difficulty consists of the large number of man-hours of work required for estimating the performances at each working regime due to the many interdependent variables involved. Since this calculus must be conducted only once the geometry of the turbine is determined, if the results are not satisfactory one must go back to the preliminary design and repeat the entire process. Taking into account all the above, this paper aims at optimizing the efficiency of a newly design turbine, while maintaining the required power output. Considering the gas-dynamic parameters used for determining the preliminary geometry of a turbine, and the influence of the geometry upon the turbine efficiency, according to the procedure stated above, a Monte Carlo optimizing method is proposed. The optimization method consists in a novel genetic algorithm, presented in the paper. The algorithm defines a population of turbine stage geometries using a binary description of their geometrical configuration as the chromosomes. The turbine efficiency is the fitness function and also acts as the mating probability criterion. The turbine energy output is verified for each member of the population in order to verify that the desired turbine power is still within acceptable limits. Random mutations carried on by chromosome string reversal are included to avoid local optima. Hard limits are imposed on optimization parameter variation in order to avoid ill defined candidate solutions. The approach presented here significantly reduces the time between design goal definition and the prototype.
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Wright, Cody, e Onur Bilgen. "A Variable Camber Piezocomposite Trailing-Edge for Subsonic Aircraft: Multidisciplinary Design Optimization". In ASME 2019 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/smasis2019-5604.

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Abstract A continuous-surface morphing airfoil is desirable for commercial aircraft in order to improve fuel efficiency, and due to the potential to morph the wing into a high-lift configuration for take-off and landing. Piezocomposite actuators have shown to be a feasible strategy for camber morphing in small unmanned fixed-wing aircraft with a Reynold’s number in the range of 50,000 to 250,000. As an extension, this paper presents a theoretical framework and results for morphing in single and multi-segment natural laminar flow airfoils with a maximum Reynold’s number of 825,000. The airfoils presented employ a continuous inextensible surface. To achieve morphing, piezocomposite actuating elements are applied on the suction and pressure surfaces of the airfoils. The geometric properties of the airfoils are determined using a genetic algorithm optimization method with a migration strategy in order to maintain population diversity. The algorithm optimizes independently the substrate thicknesses for the nominal airfoil, the leading edge, and the piezocomposite bonded surfaces. In addition, positions and voltages for each piezocomposite actuators are optimized. The genetic algorithm uses an objective function to maximize the change in coefficient of lift to morph the airfoil from its baseline (i.e. cruise) state to the high-lift state. Analysis is performed using a coupled fluid-structure interaction method assuming static aero-elastic behavior. Optimization is followed by a parametric analysis to examine lift, drag, and lift-to-drag ratio of the airfoils over their full operational range. The optimization is performed on a symmetric, asymmetric, and the aft element of a slotted multi-segment airfoil to examine the capabilities of induced-strain actuation at high dynamic pressures.

Relatórios de organizações sobre o assunto "Theoretical population genetics":

1

Bogoliubov, A. G., e C. Loehle. A theoretical analysis of population genetics of plants on restored habitats. Office of Scientific and Technical Information (OSTI), julho de 1997. http://dx.doi.org/10.2172/505323.

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2

Bogoliubov, A. G., e C. Loehle. A theoretical analysis of population genetics of plants on restored habitats. Office of Scientific and Technical Information (OSTI), fevereiro de 1995. http://dx.doi.org/10.2172/26698.

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